Title:
NUCLEIC ACID HYBRIDIZATION PROBES
Document Type and Number:
WIPO Patent Application WO/2013/102108
Kind Code:
A3
Abstract:
Compositions of nucleic acid hybridization probes for detecting a nucleic acid target sequence and methods for their production are described. In one preferred embodiment, the nucleic acid hybridization probe includes a hybridization domain, an adaptor, a linker, and a signaling domain. The hybridization domain includes a nucleic acid sequence having complementarity to the nucleic acid target sequence. The adaptor is a nucleic acid sequence. The linker includes a moiety having at least one abasic site, such that the moiety blocks extension by an elongating polymerase on a nucleic acid template containing the moiety. The signaling domain comprises a nucleic acid having at least one label or a nucleic acid having at least one nucleic acid domain for binding at least one additional nucleic acid.
Inventors:
RUSSELL JOHN C (US)
PESTOVA EKATERINA (US)
PESTOVA EKATERINA (US)
Application Number:
PCT/US2012/072114
Publication Date:
October 16, 2014
Filing Date:
December 28, 2012
Export Citation:
Assignee:
ABBOTT MOLECULAR INC (US)
International Classes:
C12Q1/68; C07H21/04
Foreign References:
| US20080286835A1 | 2008-11-20 | |||
| US20110059431A1 | 2011-03-10 | |||
| US20050059049A1 | 2005-03-17 | |||
| US20020155456A1 | 2002-10-24 | |||
| US20050118603A1 | 2005-06-02 |
Other References:
See also references of EP 2798092A4
Attorney, Agent or Firm:
CELANDER, Daniel et al. (850 West Jackson BoulevardSuite 66, Chicago IL, US)
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