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Title:
NUCLEIC ACID-LOADED UNIT POLYION COMPLEX
Document Type and Number:
WIPO Patent Application WO/2019/044937
Kind Code:
A1
Abstract:
The present invention provides a unitary polyion complex composed of a specific number of block copolymers having a polyethylene glycol segment and a cationic polyamino acid segment, and a specific number of nucleic acids, wherein the sum of the positive charge level derived from the side chains of the cationic polyamino acid segments of the block copolymer in the unitary polyion complex is not canceled out by the sum of the negative charge level derived from the nucleic acids, the nucleic acid chain is 10-50 bases long, the molecular weight of the polyethylene glycol segment is 40 × 103 or higher, and the binding constant (Ka) of the block copolymer to the nucleic acid is 3.0 × 105 or higher.

Inventors:
KATAOKA, Kazunori (66-20 Horikawa-cho, Saiwai-ku, Kawasaki-sh, Kanagawa 13, 〒2120013, JP)
MIYATA, Kanjiro (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
FUKUSHIMA, Shigeto (66-20 Horikawa-cho, Saiwai-ku, Kawasaki-sh, Kanagawa 13, 〒2120013, JP)
HAYASHI, Kotaro (66-20 Horikawa-cho, Saiwai-ku, Kawasaki-sh, Kanagawa 13, 〒2120013, JP)
WATANABE, Sumiyo (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
KIM, HyunJin (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
TOH, Kazuko (66-20 Horikawa-cho, Saiwai-ku, Kawasaki-sh, Kanagawa 13, 〒2120013, JP)
Application Number:
JP2018/032040
Publication Date:
March 07, 2019
Filing Date:
August 30, 2018
Export Citation:
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Assignee:
THE UNIVERSITY OF TOKYO (3-1 Hongo 7-chome, Bunkyo-ku Tokyo, 54, 〒1138654, JP)
KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION (66-20, Horikawa-cho Saiwai-ku, Kawasaki-sh, Kanagawa 13, 〒2120013, JP)
International Classes:
A61K31/713; A61K9/10; A61K47/34; A61K48/00; A61P35/00; C12N15/09
Domestic Patent References:
WO2013162041A12013-10-31
WO2006123631A12006-11-23
WO2005078084A12005-08-25
WO2018079841A12018-05-03
Other References:
DEROUCHEY, J. ET AL.: "Monomolecular Assembly of siRNA and Poly(ethylene glycol)-Peptide Copolymers", BIOMACROMOLECULES, vol. 9, no. 2, 2008, pages 724 - 732, XP009106452, DOI: doi:10.1021/bm7011482
Attorney, Agent or Firm:
MOMII, Takafumi (7th Floor, Aqua Dojima East 1-4-4, Dojimahama, Kita-ku, Osaka-sh, Osaka 04, 〒5300004, JP)
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