Title:
NUCLEIC ACID MOLECULES INDUCING RNA INTERFERENCE, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/053741
Kind Code:
A2
Abstract:
The present invention relates to nucleic acid molecules having a novel structure which induce RNAi, and to the uses thereof. More particularly, the present invention relates to nucleic acid molecules which have a novel structure and which increase the rate of inhibiting the expression of target genes by configuring the structure to have a first strand of 24-121 nt in length provided with a partial region complementary to a target nucleic acid, and a second strand of 13-21 nt in length provided with a region which forms a complementary bond with the partial region complementary to the target nucleic acid of the first strand. The invention further relates to a method for inhibiting the expression of the target genes using the nucleic acid molecules. The nucleic acid molecular structure according to the present invention can increase a gene inhibition rate, or increase the inhibition rate of the target genes by improving the bonding strength to the same target genes together with siRNA through the introduction of antisense DNA, antisense RNA, ribozyme, and DNAzyme, or by causing synergistic cleavage. Furthermore, the nucleic acid molecules according to the present invention enables the continuance time of a gene inhibition rate to be lengthened. Thus, the nucleic acid molecules inducing RNAi are useful since they replace the conventional siRNA molecules applicable to the treatment of cancer or of viral infection using siRNA.
Inventors:
LEE DONG KI (KR)
Application Number:
PCT/KR2011/006632
Publication Date:
April 26, 2012
Filing Date:
September 07, 2011
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN FOUND (KR)
LEE DONG KI (KR)
LEE DONG KI (KR)
International Classes:
C12N15/113; A61K31/7088; A61K48/00; A61P35/00
Foreign References:
| US20090012022A1 | 2009-01-08 | |||
| KR20090065880A | 2009-06-23 |
Other References:
ELBASHIR ET AL., NATURE, vol. 411, 2001, pages 494 - 498
SONG ET AL., NAT. STRUCT. BIOL., vol. 10, 2003, pages 1026 - 1032
WANG ET AL., NATURE, vol. 461, 2009, pages 754 - 761
See also references of EP 2631291A4
SONG ET AL., NAT. STRUCT. BIOL., vol. 10, 2003, pages 1026 - 1032
WANG ET AL., NATURE, vol. 461, 2009, pages 754 - 761
See also references of EP 2631291A4
Attorney, Agent or Firm:
LEE, Cheo Young (KR)
이처영 (KR)
이처영 (KR)
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Claims: