5 Nucleic acid molecules and uses thereof

Introduction:

The present invention is directed to an artificial nucleic acid and to polypeptides suitable for use in treatment or prophylaxis of ID an infection with Norovirus or a disorder related to such an infection. In particular, the present invention concerns a Norovirus vaccine. The present invention is directed to an artificial nucleic acid, polypeptides, compositions and vaccines comprising the artificial nucleic acid or the polypeptides. The invention further concerns a method of treating or preventing a disorder or a disease, first and second medical uses of the artificial nucleic acid, polypeptides, compositions and vaccines. Further, the invention is directed to a kit, particularly to a kit of parts, comprising the artificial nucleic acid, polypeptides, compositions and 15 vaccines.

Noroviruses (also known as Norwalk-like viruses or Norwalk viruses) are positive sense, single-stranded RNA Calciviruses (Sarvestani, Soroush I, et al. "Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response." Journal of Interferon FJ Cytokine Research 36.4 (20Ι6):2Ι5-225), containing a non-segmented RNA genome. The virusD genome is organized in three open reading frames, of which the 5' proximal DRF encodes a large polyprotein that is cleaved into non-structural proteins; the minor capsid protein VP2 is encoded by 0RF3 and the major capsid protein VPI is encoded by DRF2 (Karst et al.. Cell Host Microbe II; I5(B):BG8-8D, 2014; Robilotti E, Deresinski S, Pinsky BA. 2015. Norovirus. Clin Microbiol Rev 28:134-164). 5 Noroviruses are classified into five genogroups (Gl - GV), and are further subdivided into genotypes based on the capsid sequence (Zheng, Du-Ping, et al. "Norovirus classification and proposed strain nomenclature." Virology 34G.2 (2006):312-323; Kroneman. A., et al. "An automated genotyping tool for enteroviruses and noroviruses." Journal of Clinical Virology 51.2 (20II):I2I-I25). Mostly viruses of genogroups I, II are known to infect humans (Ramani, Sasirekha, Robert L. Atmar, and Mary K. Estes. "Epidemiology of human noroviruses and updates on vaccine development", Current opinion in gastroenterology 30.1 (20I4):25), Norwalk viruses0 (NV) genotype Gl.l was the first isolated Norovirus, however genotype GII.4 Noroviruses are currently the most frequently detected in humans (Glass, Roger I., Umesh D. Parashar, and Mary K. Estes. "Norovirus gastroenteritis." New England Journal of Medicine 361.18 (2DD9):I776-I785).

Infections with Noroviruses are generally self-limiting in healthy adults, displaying typical symptoms including non-bloody5 diarrhea, vomiting, nausea and abdominal cramps. However, in individuals with weakened immune system, including young children and elderly, infection can be severe and even fatal (Glass, Roger I., Omesh D. Parashar, and Mary K. Estes. "Norovirus gastrDEnteritis." NEW England Journal of MBdicine 361.18 (20D9):I77G-I785). Nongastrointestinal- related illness, including neuradevelopmental disorders have also been reported after Norovirus infection. (Sarvestani, Soroush I, et al. "Norovirus Infection: Replication, Manipulation of Host, and Interaction with the Host Immune Response." Journal of Interferon 5 Cytokine Research 36.4 (20l6):2l5-225).

5

Due to the low infectious dose, resistance to many common sterilization procedures, and ease of transmission, epidemic outbreaks are common and difficult to control (Glass, Roger l„ Umesh D. Parashar, and Mary K. Estes. "Norovirus gastroenteritis." New England Journal of Medicine 361.18 (20D9):I77G-I785: Hutson et al., 2DD4). NoV has been shown to be the cause of the majority of nonbacterial gastroenteritis epidemics, resulting in a huge economic burden. In the US, the cost of NoV-associated

ID hospitalizations has been estimated at approximately $500 million, while foodborne NoV cost due to healthcare and lost productivity has been estimated at $2 billion (Batz, Michael B., Sandra Hoffmann, and J. Glenn Morris Jr. "Ranking the diseasB burden of 14 pathogens in food sources in the United States using attribution data from outbreak investigations and expert elicitatiDfi." Journal of Food Protection 75.7 (20I2):I278-I2FJI). The rapid evolution of Norovirus genotypes through antigenic drift and changing glycan specificities still provide challenges in the development of potent vaccines (Ramani, Sasirekha, Robert L.

15 Atmar, and Mary K. Estes. "Epidemiology of human noroviruses and opdates on vaccine development." Current opinion in gastroentErology 3D.I (2DI4):25).

At present, there is no specific treatment of Norovirus infections. Therapy is limited to curing the symptoms caused by the infection. In addition, there is currently no vaccine available against Norovirus infections. There is therefore a strong need for aD vaccine against Norovirus infection.

The underlying objEct of the present invention is therefore to provide a Norovirus vaccine. It is a further preferred object of the invention to provide a Norovirus vaccine, which may be produced at an industrial scale. A further object of the present invention is the provision of a storage-stable Norovirus vaccine. Further object of the underlying invention is to provide mRNA sequences5 coding for antigenic peptides or proteins derived from a protein of a Norovirus or a fragment or variant thereof for the use as a vaccine for prophylaxis or treatment of Norovirus infections. Furthermore, it is the object of the present invention to provide an effective Norovirus vaccine which can be stored without cold chain and which enables rapid and scalable vaccine production.

The object underlying the present invention is solved by the claimed subject-matter. Particularly, the objects underlying the0 present invention are solved according to a first aspect by an inventive by providing an artificial nucleic acid comprising at least one coding region encoding at least one polypeptide derived from a Norovirus, aod/or a fragment or variant thereof. Definitions:

For the sake of clarity and readability the following definitions are provided. Any technical feature mentioned for these definitions may be read on each and every embodiment of the invention. Additional definitions and explanations may be specifically provided in the context of these embodiments.

Adaptive immune response: The adaptive immune response is typically understood to be an antigen-specific response of the immune system. Antigen specificity allows for the generation of responses that are tailored to specific pathogens or pathogen- infected cells. The ability to mount these tailored responses is usually maintained in the body by "memory cells". Should a pathogen infect the body more than once, these specific memory cells are used to quickly eliminate it. In this context, the first step of an adaptive immune response is the activation of naive antigen-specific T cells or different immune cells able to induce an antigen-specific immune response by antigen-presenting cells. This occurs in the lymphoid tissues and organs through which naive T cells are constantly passing. The three cell types that may serve as antigen-presenting cells are dendritic cells, macrophages, and B cells. Each of these cells has a distinct function in eliciting immune responses. Dendritic cells may take up antigens by phagocytosis and macropinocytosis and may become stimulated by contact with e.g. a foreign antigen to migrate to the local lymphoid tissue, where they differentiate into mature dendritic cells. Macrophages ingest particulate antigens such as bacteria and are induced by infectious agents or other appropriate stimuli to express MHC molecules. The unique ability of B cells to bind and internalize soluble protein antigens via their receptors may also be important to induce T cells. MHC-molecules are, typically, responsible for presentation of an antigen to T-cells. Therein, presenting the antigen on MHC molecules leads to activation of T cells which induces their proliferation and differentiation into armed effector T cells. The most important function of effector T cells is the killing of infected cells by CD8+ cytotoxic T cells and the activation of macrophages by Thl cells which together make up cell-mediated immunity, and the activation of B cells by both ThZ and Thl cells to produce different classes of antibody, thus driving the humoral immune response. T cells recognize an antigen by their T cell receptors which do not recognize and bind the antigen directly, but instead recognize short peptide fragments e.g. of pathogen-derived protein antigens, e.g. so- called epitopes, which are bound to MHC molecules on the surfaces of other cells.

Adaptive immune system: The adaptive immune system is essentially dedicated to eliminate or prevent pathogenic growth. It typically regulates the adaptive immune response by providing the vertebrate immune system with the ability to recognize and remember specific pathogens (to generate immunity), and to mount stronger attacks each time the pathogen is encountered. The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all of the progeny (offspring) of such a cell will then inherit genes encoding the same receptor specificity, including the Memory B cells and Memory T cells that are the keys to long-lived specific immunity. Adjuvant/ adjuvant component: An adjuvant OP an adjuvant component in the broadest sense is typically a pharmacological and/ or immunological agent that may modify, e.g. enhance, the effect of other agents, such as a drug or vaccine. It is to be interpreted in a broad sense and refers to a broad spectrum of substances. Typically, these substances are able to increase the immunogenic^ of antigens. For example, adjuvants may be recognized by the innate immune systems and, e.g., may elicit an 5 innate immune response. "Adjuvants" typically do not elicit an adaptive immune response. Insofar, "adjuvants" do not qualify as antigens. Their mode of action is distinct from the effects triggered by antigens resulting in an adaptive immune response.

Antigen: In the context of the present invention "antigen" refers typically to a substance which may be recognized by the immune system, preferably by the adaptive immune system, and is capable of triggering an antigen-specific immune response, e.g. by ID formation of antibodies and/ or antigen-specific T cells as part of an adaptive immune response. Typically, an antigen may be or may comprise a peptide or protein which may be presented by the MHC to T-cells. In the sense of the present invention an antigen may be the product of translation of a provided nucleic acid molecule, preferably an m NA as defined herein. In this context, also fragments, variants and derivatives of peptides and proteins comprising at least one epitope are understood as antigens. In the context of the present invention, tumour antigens and pathogenic antigens as defined herein are particularly preferred.

15

Artificial nucleic acid molecule: An "artificial nucleic acid molecule" or "artificial nucleic acid" may typically be understood to be a nucleic acid molecule, e.g. a DNA or an RNA that does not occur naturally. In other words, an artificial nucleic acid molecule may be understood as a non-natural nucleic acid molecule. Such nucleic acid molecule may be non-natural due to its individual sequence (which does not occur naturally) and/or due to other modifications, e.g. structural modifications of nucleotides whichD do not occur naturally. An artificial nucleic acid molecule may be a DNA molecule, an RNA molecule or a hybrid-molecule comprising DNA and RNA portions. Typically, artificial nucleic acid molecules may be designed and/or generated by genetic engineering methods to correspond to a desired artificial sequence of nucleotides (heterologous sequence). In this context an artificial sequence is usually a sequence that may not occur naturally, i.e. it differs from the wild type sequence by at least one nucleotide. The term "wild type" may be understood as a sequence occurring in nature. Further, the term "artificial nucleic acid5 molecule" is not restricted to mean "one single molecule" but is, typically, understood to comprise an ensemble of identical molecules. Accordingly, it may relate to a plurality of identical molecules contained in an aliquot.

Bicistronic nucleic acid or RNA and multicistronic nucleic acid or RNA: A bicistronic or multicistronic nucleic acid or RNA is typically a nucleic acid or an RNA, preferably an mRNA, that typically may have two (bicistronic) or more (multicistronic) codingD regions. A coding region in this context is a sequence of codons that is translatable into a peptide or protein.

Carrier/polymeric carrier: A carrier in the context of the invention may typically be a compound that facilitates transport and/ or complexation of another compound (cargo). A polymeric carrier is typically a carrier that is formed of a polymer. A carrier may be associated to its cargo by covalent or non-covalent interaction. A carrier may transport nucleic acids, e.g. RNA or DNA, to the5 target cells. The carrier may - for some embodiments - be a cationic component. Complexation and Formulation: According to a preferred embodiment, the at least one m NA of the inventive composition may be complexed with lipids to form one or more liposomes, lipoplexes, or lipid nanoparticles. Therefore, in one embodiment, the inventive composition comprises liposomes, lipoplexes, and/or lipid nanoparticles comprising the at least one mRNA.

5 Lipid-based formulations have been increasingly recognized as one of the mast promising delivery systems for RNA due to their biocompatibility and their ease of large-scale production. Cationic lipids have been widely studied as synthetic materials for delivery of RNA. After mixing together, nucleic acids are condensed by cationic lipids to form lipid/ nucleic acid complexes known as lipoplexes. These lipid complexes are able to protect genetic material from the action of nucleases and deliver it into cells by interacting with the negatively charged cell membrane. Lipoplexes can be prepared by directly mixing positively charged lipids

ID at physiological pH with negatively charged nucleic acids. Conventional liposomes consist of a lipid bilayer that can be composed of cationic, anionic, or neutral (phospho)lipids and cholesterol, which encloses an aqueous core. Both the lipid bilayer and the aqueous space can incorporate hydrophobic or hydrophilic compounds, respectively. Liposome characteristics and behaviour in vivo can be modified by addition of a hydrophilic polymer coating, e.g. polyethylene glycol (PEG), to the liposome surface to confer steric stabilization. Furthermore, liposomes can be used for specific targeting by attaching ligands (e.g., antibodies, peptides,

15 and carbohydrates) to its surface or to the terminal end of the attached PEG chains (Front Pharmacol. 2DI5 Dec l;B:28B).Liposomes are colloidal lipid-based and surfactant-based delivery systems composed of a phospholipid bilayer surrounding an aqueous compartment. They may present as spherical vesicles and can range in size from 20 nm to a few microns. Cationic lipid-based liposomes are able to complex with negatively charged nucleic acids via electrostatic interactions, resulting in complexes that offer biocompatibility, low toxicity, and the possibility of the large-scale production required for in vivo clinicalD applications. Liposomes can fose with the plasma membrane for uptake; once inside the cell, the liposomes are processed via the endocytic pathway and the genetic material is then released from the endnsome/carrier into the cytoplasm. Liposomes have long been perceived as drug delivery vehicles because of their superior biocompatibility, given that liposomes are basically analogs of biological membranes, and can be prepared from both natural and synthetic phospholipids (Int J Nanomedicine.2014; 3:1833-1843).

5

Cationic liposomes have been traditionally the most commonly used non-viral delivery systems for oligonucleotides, including plasmid DNA, antisense oligos, and siRNA/small hairpin RNA-shRNA). Cationic lipids, such as DDTAP, (l,2-dioleoyl-3- trimethylammonium-propane) and DOTMA (N-[l-(2,3-dmleoyloxy)propyl]-N,N,N-trimethyl-ammonium methyl sulfate) can form complexes or lipoplexes with negatively charged nucleic acids to form nanoparticles by electrostatic interactioo, providing highD in vitro transfection efficiency . Furthermore, neutral lipid-based nanoliposomes for RNA delivery as e.g. neutral 1,2-diolBoyl-sn- glycero-3-phosphatidylchaline (DOPC)-based nanoliposomes were developed. (Adv Drug Deliv Rev.2DI4 Feb; 66:110-116).

Therefore, in one embodiment the at least one mRNA of the inventive compositioo is complexed with cationic lipids and/ or neutral lipids and thereby forms liposomes, lipid nanoparticles, lipoplexes or neutral lipid-based nanoliposomes. Cationic campanent or catipnic compound: The term "cationic component" or "cationic compound" typically refers to a charged molecule, which is positively charged (cation) at a pH value typically from I to 3, preferably at a pH value of or below 9 (e.g. from 5 to 9), of or below 8 (e.g. from 5 to 8), of or below 7 (e.g. from 5 to 7), most preferably at a physiological pH, e.g. from 7.3 to 7.4. Accordingly, a cationic component may be any positively charged compound or polymer, preferably a cationic peptide or

5 protein which is positively charged under physiological conditions, particularly under physiological conditions in vivo. Further accordingly, a cationic peptide, protein, polysaccharide, lipid or polymer according to the present invention is positively charged under physiological conditions, particularly under physiological salt conditions of the cell in vivo. A "cationic peptide or protein" may contain at least one positively charged amino acid, or more than one positively charged amino acid, e.g. selected from Arg, His, Lys or Drn. Accordingly, "polycationic" components or compounds are also within the scope exhibiting more than one positive

ID charge under the conditions given.

5'-cap: A 5'-cap is an entity, typically a modified nucleotide entity, which generally "caps" the S'-end of a mature mRNA. A 5'-cap may typically be formed by a modified nucleotide, particularly by a derivative of a guanine nucleotide. Preferably, the 5'-cap is linked to the 5'-terminus via a 5'-5'-triphosphate linkage. A 5'-cap may be methylated, e.g. m7GpppN, wherein N is the terminal

15 5' nucleotide of the nucleic acid carrying the 5'-cap, typically the 5'-end of an RNA. Further examples of 5'cap structures include glyceryl, inverted deoxy abasic residue (moiety), 4',5' methylene nucleotide, l-(beta-D-erythrofuranosyl) nucleotide, 4'-thio nucleotide, carbocyclic nucleotide, 1,5-anhydrohexitol nucleotide, L-nucleotides, alpha-nucleotide, modified base nucleotide, threo-pentofuranosyl nucleotide, acyclic 3',4'-seco nucleotide, acyclic 3,4-dihydroxybutyl nucleotide, acyclic 3,5 dihydroxypentyl nucleotide.3'-3'-inverted nucleotide moiety, 3'-3'-inverted abasic moiety, 3'-2'-inverted nucleotide moiety, 3'-2'-inverted abasicD moiety, 1,4-butanediol phosphate. 3'-phosphoramidate, hexylphosphate. aminohexyl phosphate, 3'-phosphate, 3'phosphorothioate, phosphorodithioatE, or bridging or παπ-bridging methylpfiDsphonate moiety.

Cap analogue: A cap analogue refers to a non-polymerizable di-nucleotide that has cap functionality in that it facilitates translation or localization, and/or prevents degradation of a nucleic acid molecule, particularly of an RNA molecule, when5 incorporated at the 5' end of the nucleic acid molecule. Non-polymerizable means that the cap analogue will be incorporated only at the 5'-terminus because it does not have a 5' triphosphate and therefore cannot be extended in the 3' direction by a template- dependent polymerase, particularly, by template-dependent RNA polymerase.

Cap analogues include, but are not limited to, a chemical structure selected from the group consisting of m7GpppG, m7GpppA,D m7GpppC; unmethylated cap analogues (e.g., GpppG); dimethylated cap analogue (e.g., m2.7GpppG), trimethylated cap analogue (e.g., m2,2,7GpppG), dimethylated symmetrical cap analogues (e.g., m7Gpppm7G), or anti reverse cap analogues (e.g., ARCA; m7,2'0meGpppG. m7,2'dGpppG, m7,3'0meGpppG, m7.3'dGpppG and their tetraphosphate derivatives) (Stepinski et al„ 2DDI. RNA 7(ID):l48G-95). Further cap analogues have been described previously (US 7,074.596, WO 20D8/0I6473. WD 2008/157688. WO 2009/149253. WO 2011/015347, and WO 2013/059475). The synthesis of N7-(4-chlorophenoxyethyl) substituted dinucleotide cap analogues has been described recently (Kore et al. (2013) Bioorg. Med. Chem.2l(l5):4570-4). 5'-cap-Structure: A 5'-cap is typicallya a modified nucleotide (cap analogue), particularly a guanine nucleotide, added to the 5' end of a nucleic acid molecule, particularly of an RNA molecule, e.g. an mRNA molecule. Preferably, the 5'- cap is added using a 5'-5'-triphosphate linkage (also named m7GpppN). Further examples of 5'- cap structures include glyceryl, inverted deoxy abasic residue (moiety), 4',5' methylene nucleotide, l-(beta-D-erythrofuranosyl) nucleotide, 4'-thio nucleotide, carbocyclic nucleotide. 1,5-anhydrohexitol nucleotide, L-nucleotides, alpha-nucleatide, modified base nucleotide, thren-pentofuranosyl nucleotide, acyclic 3',4'-seco nucleotide, acyclic 3,4-dihydroxybutyl nucleotide, acyclic 3,5 dihydroxypentyl nucleotide, 3'-3'-inverted nucleotide moiety, 3'-3'-inverted abasic moiety, 3'-2'-inverted nucleotide moiety, 3'-2'-inverted abasic moiety, 1,4-butanediol phosphate, 3'- phasphoramidate, hexylphosphate, aminohexyl phosphate, 3'-phasphate, 3'phosphorothioate, phosphorodithioate, or bridging or non-bridging methylphosphonate moiety. These modified 5'-cap structures may be used in the context of the present invention to modify the mRNA sequence of the inventive composition. Further modified 5'-cap structures which may be used in the context of the present invention are cap I (additional methylation of the ribose of the adjacent nucleotide of m7GpppN), cap2 (additional methylation of the ribose of the 2nd nucleotide downstream of the m7GpppN), cap3 (additional methylation of the ribose of the 3rd nucleotide downstream of the m7GpppN), cap4 (additional methylation of the ribose of the 4th nucleotide downstream of the m7GpppN), ARCA (anti-reverse cap analogue), modified ARCA (e.g. phosphothioate modified ARCA), inosine, Nl-methyl-guanosine, 2'-fluoro-guanosine, 7-deaza-guanosine, 8-oxo-guanosine, 2-amino-guanosine, LNA-guanosine, and 2-azido-guanosine.

In the context of the present invention, a 5' cap structure (capO or capl) may also be formed in chemical RNA synthesis or RNA in vitro transcription (co-transcriptional capping) using cap analogues, or a cap structure may be formed in vitro using capping enzymes (e.g., commercially available capping kits). A cap structure (e.g., capO or capl) may also be formed in vitro using immobilized capping enzymes, e.g. in a capping reactor as described in W02016/193226.

Ghemical synthesis of nucleic acids: Chemical synthesis of relatively short fragments of oligonucleotides with defined chemical structure provides a rapid and inexpensive access to custom-made oligonucleotides of any desired sequence. Whereas enzymes synthesize DNA and RNA only in the 5' to 3' direction, chemical oligonucleotide synthesis does not have this limitation, although it is most often carried out in the opposite, i.e. the 3' to 5' direction. Currently, the process is implemented as solid-phase synthesis using the phosphoramidite methnd and phosphoramidite building blocks derived from protected nucleosides (A, C, G, and U), or chemically modified nucleosides.

To obtain the desired oligonucleotide, the building blocks are sequentially coupled to the growing oligonucleotide chain on a solid phase in the order required by the sequence of the product in a fully automated process. Upon the completion of the chain assembly, the product is released from the solid phase to the solution, deprotected, and collected. The occurrence of side reactions sets practical limits for the length of synthetic oligonucleotides (up to about 20D nucleotide residues), because the number of errnrs increases with the length of the oligonucleotide being synthesized. Products are often isolated by HPLC to obtain the desired oligonucleotides in high purity.

Chemically synthesized oligonucleotides find a variety of applications in molecular biology and medicine. They are most commonly 5 used as antisense oligonucleotides, small interfering RNA, primers for DNA sequencing and amplification, probes for detecting complementary DNA or RNA via molecular hybridization, tools for the targeted introduction of mutations and restriction sites, and for the synthesis of artificial genes. Moreover, long-chain DNA molecules and long-chain RNA molecules may be chemically synthetized and used in the context of the present invention.

ID Cellular immunity/cellular immune response: Cellular immunity relates typically to the activation of macrophages, natural killer cells (NK). antigen-specific cytotoxic T-lymphncytes, and the release of various cytokines in response to an antigen. In more general terms, cellular immunity is not based on antibodies, but on the activation of cells of the immune system. Typically, a cellular immune response may be characterized e.g. by activating antigen-specific cytotoxic T-lymphocytes that are able to induce apoptosis in cells, e.g. specific immune cells like dendritic cells or other cells, displaying epitopes of foreign antigens on

15 their surface. Such cells may be virus-infected or infected with intracellular bacteria, or cancer cells displaying tumor antigens.

Further characteristics may be activation of macrophages and natural killer cells, enabling them to destroy pathogens and stimulation of cells to secrete a variety of cytokines that influence the function of other cells involved in adaptive immune responses and innate immune responses. 0 Cloning site: A cloning site is typically understood to be a segment of a nucleic acid molecule, which is suitable for insertion of a nucleic acid sequence, e.g., a nucleic acid sequence comprising a coding region. Insertion may be performed by any molecular biological method known to the one skilled in the art, e.g. by restriction and ligation. A cloning site typically comprises Dne or more restriction enzyme recognition sites (restriction sites). These Dne or more restrictions sites may be recognized by restriction enzymes which cleave the DNA at these sites. A cloning site which comprises more than one restriction site may also5 be termed a multiple cloning site (MCS) or a polylinker.

Coding region, coding sequence: A coding region, in the context of the invention, is typically a sequence of several nucleotide triplets, which may be translated into a peptide or protein. A coding region preferably contains a start codon, i.e. a combination of three subsequent nucleotides coding usually for the amino acid methionine (ATG), at its 5'-end and a subsequent region whichD usually exhibits a length which is a multiple of 3 nucleotides. A coding region is preferably terminated by a stop-codon (e.g., TAA, TAG, TGA). Typically, this is the only stop-codon of the coding region. Thus, a coding region in the context of the present invention is preferably a nucleotide sequence, consisting of a number of nucleotides that may be divided by three, which starts with a start codon (e.g. ATG) and which preferably terminates with a stop codon (e.g., TAA, TGA, or TAG). The coding region may be isolated or it may be incorporated in a longer nucleic acid sequence, for example in a vector or an mRNA. In the context of the present5 invention, a coding region may also be termed "protein coding region", "coding sequence", "CDS", "open reading frame" or "DRF". Derived from: The phrase "derived from" as used throughout the present specification in the context of a nucleic acid, i.e. for a nucleic acid "derived from" (another) nucleic acid, means that the nucleic acid, which is derived from (another) nucleic acid, shares at least 50%, preferably at least 60%, preferably at least 70%, more preferably at least 75%, more preferably at least 80%, more preferably at least 85%, even more preferably at least 90%, even more preferably at least 95%, and particularly preferably at least 98% sequence identity with the nucleic acid from which it is derived. In one embodiment, "derived from" means having in increasing order of preference at least 50%, 51%, 52%, 53%, 54%, 55%, 56%. 57%, 58%, 58%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%. 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to the sequences as represented by SEQ 10 NOs: 1-39690. 39713-39746. The skilled person is aware that sequence identity is typically calculated for the same types of nucleic acids, i.e. for DNA sequences or for RNA sequences. Thus, it is understood, if a DNA is "derived from" an RNA or if an RNA is "derived from" a DNA. in a first step the RNA sequence is converted into the corresponding DNA sequence (in particular by replacing the uracils (U) by thymidines (T) throughout the sequence) or, vice versa, the DNA sequence is converted into the corresponding RNA sequence (in particular by replacing the thymidines (T) by uracils (U) throughout the sequence). Thereafter, the sequence identity of the DNA sequences or the sequence identity of the RNA sequences is determined. Preferably, a nucleic acid "derived from" a nucleic acid also refers to nucleic acid, which is modified in comparison to the nucleic acid from which it is derived, e.g. in order to increase RNA stability even further and/ or to prolong and/or increase protein production. It goes without saying that such modifications are preferred, which do not impair RNA stability, e.g. in comparison to the nucleic acid from which it is derived. Different Noro virus: The term "different Noro virus" in the context of the invention has to be understood as the difference between at least two respective Noroviruses, wherein the difference is manifested on the RNA genome of the respective different virus. In the broadest sense, "different Norovirus" has to be understood as genetically "different Norovirus". Particularly, said (genetically) different Noroviruses express at least one different protein or peptide, wherein the at least one different protein or peptide preferably differs in at least one amino acid.

Same Norovirus: In the broadest sense, "same Norovirus" has to be understood as genetically the same. Particularly, said (genetically) same virus expresses the same proteins or peptides (e.g., at least one structural and/or non-structural protein), wherein all proteins or peptides have the same amino acid sequence. DNA: DNA is the usual abbreviation for deoxyribonucleic acid. It is a nucleic acid molecule, i.e. a polymer consisting of nucleotides. These nucleotides are usually deoxy-adenosine-monophosphate, deoxy-thymidine-monophosphate, deoxy-guanasine- monaphasphate and deoxy-cytidine-monophosphate monomers which are - by themselves - composed of a sugar moiety (deoxyribose), a base moiety and a phosphate moiety, and polymerize by a characteristic backbone structure. The backbone structure is, typically, formed by phosphodiester bonds between the sugar moiety of the nucleotide, i.e. deoxyribose, of a first and a phosphate moiety of a second, adjacent monomer. The specific order of the monomers, i.e. the order of the bases linked to the sugar/phosphate-backbone, is called the ONA sequence. DNA may be single stranded or double stranded. In the double stranded farm, the nucleotides of the first strand typically hybridize with the nucleotides of the second strand, e.g. by A/T-base- pairing and G/C-base-pairing.

Mono-, bi- and multieistronic and multi-antigen nucleic acids: A monocistronic nucleic acid may typically be a DNA or RNA, 5 particularly an mRNA that comprises only one coding sequences. A coding sequence in this context is a sequence of several nucleotide triplets (codons) that can be translated into a peptide or protein

According to a further embodiment the coding region of the at least one mRNA of the composition may encode at least two, three, four, five, six. seven, eight and more antigens (or fragments and derivatives thereof) linked with or without an amino acid linker ID sequence, wherein said linker sequence can comprise rigid linkers, flexible linkers, cleavable linkers (e.g., self-cleaving peptides) or a combination thereaf. Therein, the antigens may be identical or different or a combination thereof. According to the present invention, specific antigen and/or epitope combinations according to the paragraph "specific antigen combinations" disclosed above are particularly envisioned. Particular antigen/epitope combinations can be encoded by said mRNA encoding at least two antigens as explained abovE (herein referred to as "multi-antigen-constructs/mRNA").

I5

According to a further embodiment the composition of the present invention, may comprise a mixture of at least one monocistronic mRNA, as defined above, and/ or at least one bicistronic mRNA as defined above, and/ or at least one multieistronic mRNA, as defined above, and/ or at least one multi-antigen-constructs as defined above, and any combinations thereof. According to the present invention, specific antigen combinations according to the paragraph "specific antigen combinations" disclosedD above are particularly envisioned and may be generated using a combination of mono-, bi-, multieistronic mRNA and multi- antigen-constructs.

According to certain embodiments of the present invention, the mRNA sequence is mono-, bi-, or multieistronic, preferably as defined herein. The coding sequences in a bi- or multieistronic mRNA preferably encode distinct peptides or proteins as defined5 herein or a fragment or variant thereof. Preferably, the coding sequences encoding two or more peptides or proteins may be separated in the bi- or multieistronic mRNA by at least one IRES (internal ribosomal entry site) sequence, as defined below. Thus, the term "encoding two or more peptides or proteins" may mean, without being limited thereto, that the bi- or even multieistronic mRNA, may encode e.g. at least two, three, four, five, six or more (preferably different) peptides or proteins or their fragments or variants within the definitions provided herein. More preferably, without being limited thereto, the bi- or even multieistronicD mRNA. may encode, for example, at least two, three, four, five, six or more (preferably different) peptides or proteins as defined herein or their fragments or variants as defined herein. In this context, a so-called IRES (internal ribosomal entry site) sequence as defined above can function as a sole ribosome binding site, but it can also serve to provide a bi- or even multieistronic mRNA as defined above, which encodes several peptides or proteins which are to be translated by the ribosomes independently of one another. Examples of IRES sequences, which can be used according to the invention, are those from picornavirusBS (e.g. FMDV),5 pestiviruses (CFFV), poxviruses (PV). encephalomyocarditis viruses (ECMV), foot and mouth disease viruses (FMDV), hepatitis C viruses (HCV), classical swine fever viruses (CSFV), mouse leukoma virus (MLV), simian immunodeficiency viruses (SIV) ar cricket paralysis viruses (CrPV).

According to a further embodiment the at least one coding region of the mRNA sequence according to the invention may encode 5 at least two, three, four, five, six, seven, eight and more peptides or proteins (or fragments and derivatives thereof) as defined herein linked with or without an amino acid linker sequence, wherein said linker sequence can comprise rigid linkers, flexible linkers, cleavable linkers (e.g., self-cleaving peptides) or a combination thereof. Therein, the peptides or proteins may be identical or different or a combination thereof. Particular peptide or protein combinations can be encoded by said mRNA encoding at least two peptides or proteins as explained herein (also referred to herein as "multi-antigen-constructs/mRNA").

IQ

Epitope: (also called "antigen determinant") can be distinguished in T cell epitopes and B cell epitopes. T cell epitopes or parts of the proteins in the context of the present invention may comprise fragments preferably having a length of about 6 to about 2D or even more amino acids, e.g. fragments as processed and presented by MHC class I molecules, preferably having a length of about 8 to about ID amino acids, e.g.8, 9, or ID, (or even II, or I2 amino acids), or fragments as processed and presented by MHC

I5 class II molecules, preferably having a length of about I3 or more amino acids, e.g. I3, 14, I5, IB, I7, 18, IB, 20 or even more amino acids, wherein these fragments may be selected from any part of the amino acid sequence. These fragments are typically recognized by T cells in form of a complex consisting of the peptide fragment and an MHC molecule, i.e. the fragments are typically not recognized in their native form. B cell epitopes are typically fragments located on the outer surface of (native) protein or peptide antigens as defined herein, preferably having 5 to I5 amino acids, more preferably having 5 to I2 amino acids, even moreD preferably having B to 3 amino acids, which may be recognized by antibodies, i.e. in their native form. Such epitopes of proteins or peptides may furthermore be selected from any of the herein mentioned variants of such proteins or peptides. In this context antigenic determinants can be conformational or discontinuous epitopes which are composed of segments of the proteins or peptides as defined herein that are discontinuous in the amino acid sequence of the proteins or peptides as defined herein but are brought together in the three-dimensional structure or continuous or linear epitopes which are composed of a single5 polypeptide chain.

Fragment of a sequence: A fragment of a sequence may typically be a shorter portion of a full-length sequence of e.g. a nucleic acid molecule or an amino acid sequence. Accordingly, a fragment, typically, consists of a sequence that is identical to the corresponding stretch within the full-length sequence. A preferred fragment of a sequence in the context of the present invention,D consists of a continuous stretch of entities, such as nucleotides or amino acids corresponding to a continuous stretch of entities in the molecule the fragment is derived from, which represents at least 5%, ID , 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 00%, even more preferably at least 70%, and most preferably at least 80% of the total (i.e. full-length) molecule from which the fragment is derived. 5 G/C modified: A G/C-modified nucleic acid may typically be a nucleic acid, preferably an artificial nucleic acid molecule as defined herein, based on a modified wild type sequence comprising a preferably increased number of guanosine and/or cytosine nucleotides as compared to the wild type sequence. Such an increased number may be generated by substitution of cndons containing adenosine or thymidine nucleotides by cndons containing guanosine or cytosine nucleotides. If the enriched G/C content occurs in a coding region of DNA or RNA. it makes use of the degeneracy of the genetic code. Accordingly, the codon substitutions preferably do not alter the encoded amino acid residues, but exclusively increase the G/C content of the nucleic 5 acid molecule.

Gene therapy: Gene therapy may typically be understood to mean a treatment of a patient's body or isolated Elements of a patient's body, for example isolated tissues/cells, by nucleic acids encoding a peptide or protein. It typically may comprise at least one of the steps of a) administration of a nucleic acid, preferably an artificial nucleic acid molecule as defined herein, I0 directly to the patient - by whatever administration route - or in vitro to isolated cells/tissues of the patient, which results in transfectian of the patient's cells either in vivo/ ex vivo or in vitro; b) transcription and/ or translation of the introduced nucleic acid molecule; and optionally c) re-administration of isolated, transfected cells to the patient, if the nucleic acid has not been administered directly to the patient.

I5 Genetic vaccination: Genetic vaccination may typically be understood to be vaccination by administration of a nucleic acid molecule encoding an antigen or an immunngen or fragments thereof. The nucleic acid molecule may be administered to a subject's body or to isolated cells of a subject. Upon transfection of certain cells of the body or upon transfection of the isolated cells, the antigen or immunogen may be expressed by those cells and subsequently presented to the immune system, eliciting an adaptive, i.e. antigen-specific immune response. Accordingly, genetic vaccination typically comprises at least one of the steps ofD a) administration of a nucleic acid, preferably an artificial nucleic acid molecule as defined herein, to a subject, preferably a patient, or to isolated cells of a subject, preferably a patient, which usually results in transfection of the subject's cells either in vivo or in vitro; b) transcription and/or translation of the introduced nucleic acid molecule; and optionally c) re-administration of isolated, transfected cells to the subject, preferably the patient, if the nucleic acid has not been administered directly to the patient.

5

Genotype, genotype of a virus: The terms "genotype" or "genotype of a virus" have to be understood as the genetic constitution of an individual or a group or class of organisms having the same genetically consistent structure. Genotyping means determining differences in the genetic of an individual. In the context of the invention, Noruvirus genotype has to be understood as a Noro virus having the same genetically consistent structure.

0

Heterologous sequence: Two sequences are typically understood to be "heterologous" if they are not derivable from the same gene or in the same allele. I.e., although heterologous sequences may be derivable from the same organism, they naturally (in nature) do not occur in the same nucleic acid molecule, such as in the same mRNA. H ^p fTiDioq of a nucleic acid sequence: The term "homolog" of a nucleic acid sequence refers to sequences of other species than the particular sequence. It is particularly preferred that the nucleic acid sequence is of human origin and therefore it is preferred that the homolog is a homolog of a human nucleic acid sequence.

5 Humoral immunity/humoral immune response: Humoral immunity refers typically to antibody production and optionally to accessory processes accompanying antibody production. A humoral immune respanse may be typically characterized, e.g., by Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation. Humoral immunity also typically may refer to the effector functions of antibodies, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination.

I0

Immunngen: In the context of the present invention an immunogen may be typically understood to be a compound that is able to stimulate an immune respanse. Preferably, an immunogen is a peptide, polypeptide, or protein. In a particularly preferred embodiment, an immunogen in the sense of the present invention is the product of translation of a provided nucleic acid molecule, preferably an artificial nucleic acid molecule as defined herein. Typically, an immunogen elicits at least an adaptive immune I5 response.

Immunostimulatory composition: In the context of the invention, an immunostimulatory composition may be typically understood to be a composition containing at least one component which is able to induce an immune response or from which a component which is able to induce an immune response is derivable. Such immune response may be preferably an innate immune response0 or a combination of an adaptive and an innate immune response. Preferably, an immunostimulatory composition in the context of the invention contains at least one artificial nucleic acid molecule, more preferably an HA, for example an mRNA molecule. The immunostimulatory component, such as the m NA may be complexed with a suitable carrier. Thus, the immunostimulatory composition may comprise an mRNA/carrier-camplex. Furthermore, the immunostimulatory composition may comprise an adjuvant and/ or a suitable vehicle for the immunostimulatory component, such as the mRNA.

5

Immune response: An immune response may typically be a specific reaction of the adaptive immune system to a particular antigen (so called specific or adaptive immune response) or an unspecific reaction of the innate immune system (so called unspecific or innate immune response), or a combination thereof. 0 Immune system: The immune system may protect organisms from infection. If a pathogen succeeds in passing a physical barrier of an organism and enters this organism, the innate immune system provides an immediate, but non-specific response. If pathogens evade this innate response, vertebrates possess a second layer of protection, the adaptive immune system. Here, the immune system adapts its response during an infection to improve its recognition of the pathogen. This improved response is then retained after the pathogen has been eliminated, in the form of an immunological memory, and allows the adaptive immune5 system to mount faster and stronger attacks each time this pathogen is encountered. According to this, the immune system comprises the innate and the adaptive immune system. Each of these two parts typically contains so called humoral and cellular components.

Immunostimulatory RNA: An immunostimulatory NA (isRNA) in the context of the invention may typically be an RNA that is able 5 to induce an innate immune response. It usually does not have a coding region and thus does not provide a peptide-antigen or immunogen but elicits an immune response e.g. by binding to a specific kind of Toll-like-receptor (TLR) or other suitable receptors. However, of course also mRNAs having a coding region and coding for a peptide/protein may induce an innate immune response and, thus, may be immunostimulatory RNAs.

ID Innate immune system: The innate immune system, also known as non-specific (or unspecific)

immune system, typically comprises the cells and mechanisms that defend the host from infection by other organisms in a non ^¬ specific manner. This means that the cells of the innate system may recognize and respond to pathogens in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. The innate immune system may be. e.g., activated by ligands of Toll-like receptors (TLRs) or other auxiliary substances such as lipopnlysaccharides, TNF-

I5 alpha, C04D ligand, or cytokines, monokines, lymphokines. interleukins or chemokines, IL-I. IL-2, IL-3, IL-4, IL-5, IL-G. IL-7, IL-8, IL-B, IL-ID, IL-II. IL-IZ. IL-I3, IL-I4. IL-I5, IL-IB, IL-I7, IL-IB. IL-I9. IL-2D, IL-2I, IL-22. IL-23. IL-24, IL-25, IL-2B, IL-27. IL-28, IL-29, IL- 3D, IL-3I, IL-32, IL-33. IFN-alpha, IFN-beta, IFN-gamma, GM-CSF, G-CSF. M-CSF, LT-beta, TNF-alpha, growth factors, and hGH, a ligand of human Toll-like receptor TLRI, TLR2, TLR3, TLR4, TLR5, TLRG, TLR7, TLR8, TLR9, TLRID, a ligand of murine Toll-like receptor TLRI, TLR2, TLR3, TLR4, TLR5, TLRG, TLR7, TLRS, TLRG, TLRID, TIM TLRI2 or TLRI3, a ligand of a NOD-like receptor, a ligand of aD RIG-I like receptor, an immunostimulatory nucleic acid, an immunostimulatory RNA (isRNA), a CpG-DNA, an antibacterial agent, or an anti-viral agent. The pharmaceutical composition according to the present invention may comprise one or more such substances. Typically, a response of the innate immune system includes recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines; activation of the complement cascade; identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialized white blood cells;5 activation of the adaptive immune system; and/ or acting as a physical and chemical barrier to infectious agents.

Jet injection: The term "jet injection", as used herein, refers to a needle-free injection method, wherein a fluid containing at least one inventive nucleic acid seguence (e.g., RNA, DNA, mRNA) and, optionally, further suitable excipients is forced through an orifice, thus generating an ultra-fine liquid stream of high pressure that is capable of penetrating mammaliao skin and, depending on theD injection settings, subcutaneous tissue or muscle tissue. In principle, the liquid stream forms a hole in the skin, through which the liquid stream is pushed into the target tissue. Preferably, jet injection is used for intradermal, subcutaneous or intramuscular injection of the mRNA sequence according to the invention. In a preferred embodiment, jet injection is used for intramuscular injection of the mRNA sequence according to the invention. In a further preferred embodiment, jet injection is used for intradermal injection of the mRNA sequence according to the invention.

5 Monovalent/monovalent vaccine: A monovalent vaccine, also called univalent vaccine, is designed against a single antigen for a single organism. The term "monovalent vaccine" includes the immunization against a single valence. In the context of the invention, a monovalent Norovirus vaccine would comprise a vaccine comprising an artificial nucleic acid encoding one single antigenic peptide or protein derived from one specific Norovirus strain.

Nucleic acid molecule: A nucleic acid molecule, an artificial nucleic acid, or nucleic acid is a molecule comprising, preferably consisting of nucleic acid components. The terms nucleic acid molecule, artificial nucleic acid, or nucleic acid preferably refer to DNA or RNA molecules and vice versa. It is preferably used synonymous with the term "palynucleotide". Preferably, a nucleic acid molecule is a polymer comprising or consisting of nucleotide monomers, which are covalently linked to each other by phosphodiester-bonds of a sugar/phosphate-backbone. The terms "nucleic acid molecule", "artificial nucleic acid" or "nucleic acid" also encompasses modified nucleic acid molecules, such as base-modified, sugar-modified or backbone-modified etc. It encompasses any type of DNA or RNA molecules.

Nucleic acid sequence/amino acid: The sequence of a nucleic acid molecule is typically understood to be the particular and individual order, i.e. the succession of its nucleotides. The sequence of a protein or peptide is typically understood to be the order, i.e. the succession of its amino acids.

Peptide: A peptide or polypeptide is typically a polymer of amino acid monomers, linked by peptide bonds. It typically contains less than 5D monomer units. Nevertheless, the term peptide is not a disclaimer for molecules having more than 50 monomer units. Long peptides are also called polypeptides, typically having between 50 and 600 monomeric units. The term "polypeptide" as used herein, however, is typically not limited by the length of the molecule it refers to. In the context of the present invention, the term "polypeptide" may also be used with respect to peptides comprising less than 50 (e.g. I0) amino acids or peptides comprising even more than GOO amino acids. Also, the terms "polypeptide", "peptide", and "protein" are used interchangeably herein to refer to polymers of amino acids of any length.

Pharmaceutically effective amount: A pharmaceutically effective amount in the context of the invention is typically understood to be an amount that is sufficient to induce a pharmaceutical effect, such as an immune response, altering a pathological level of an expressed peptide or protein, or substituting a lacking gene product, e.g., in case of a pathological situation.

Protein: A protein typically comprises one or more peptides or polypeptides. A protein is typically folded into S-dimensional form, which may be required for the protein to exert its biological function.

Polv(A) sequence: A poly(A) sequence, also called poly(A) tail or 3'-poly(A) tail, is typically understood to be a sequence of adenosine nucleotides, e.g., of up to about 4D0 adenosine nucleotides, e.g. from about 2D to about 4DD, preferably from about 50 to about 40D, more preferably from about 50 to about 300, even more preferably from about 50 to about 250, most preferably from about B0 to about 250 adenosine nucleotides. A poly(A) sequence is typically located at the 3'-end of an mRNA. In the context of the present invention, a poly(A) sequence may be located within an m NA or any other nucleic acid molecule, such as, e.g., in a vector, for example, in a vector serving as template for the generation of an RNA, preferably an mRNA, e.g., by transcription of the vector. Moreover, poly(A) sequences, or poly(A) tails may be generated in vitro by enzymatic polyadenylation of the RNA, e.g. using Pnly(A)polymerases (PAP) derived from E.coli or yeast. In addition, polyadenylation of RNA can be achieved by using 5 immobilized PAP eozymes e.g. in a polyadenylation reactor (WD 2DIB/I7427I).

Poly(C) sequence: A poly(C) sequence is typically a long sequence of cytosine nucleotides, typically about ID to about 2D0 cytosine nucleotides, preferably about ID to about I00 cytosine nucleotides, more preferably about ID to about 7D cytosine nucleotides or even more, preferably about 2D to about 50, or even about 2D to about 3D cytosine nucleotides. A poly(C) sequence may ID preferably be located 3' of the coding sequence comprised by a nucleic acid.

Polyadenylation: Polyadenylation is typically understood to be the addition of a poly(A) sequence to a nucleic acid molecule, such as an RNA molecule, e.g. to a premature mRNA. Polyadenylation may be induced by a so called polyadenylation signal. This signal is preferably located within a stretch of nucleotides at the 3'-end of a nucleic acid molecule, such as an RNA molecule, to be I5 polyadenylated. A polyadenylation signal typically comprises a hexamer consisting of adenine and uracil/thymine nucleotides, preferably the hexamer sequence AAUAAA. Other sequences, preferably hexamer sequences, are alsD conceivable. Polyadenylation typically occurs during processing of a pre-mRNA (also called premature-mRNA). Typically, RNA maturation (from pre-mRNA to mature mRNA) comprises the step of polyadenylation. 0 Polyvalent/polyvalent vaccine: A polyvalent vaccine, called also multivalent vaccine, containing antigens from more than one strain of a virus, or different antigens of the same virus, or any combination thereof. The term "polyvalent vaccine" describes that this vaccine has more than one valence. In the context of the invention, a polyvalent Norovirus vaccine would comprise a vaccine camprising an artificial nucleic acid encoding antigenic peptides or proteins derived from several different Norovirus strains or comprising artificial nucleic acid encoding different antigens from the same Norovirus strain, or a combination thereof.5 In preferred embodiment, a polyvalent Norovirus vaccine comprises 2, 3, 4, 5, B, 7, 8, 9, ID, II, I2, 13, 14, 15, IB, I7, 18, 19, 2D, 21, 22, 23, 24, 25, 2B, 27, 28, 2D, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 0, 142, 43, 4, 45, 4B, 47.48, 49, 50, 51, 52, 53, 54, 55, 5B, 57, 58, 59, BO, Bl, B2, B3, B4, B5, BB, B7, B8, B9, 70, 71, 72, 3, 74, 75, 7B, 77, 78, 79, 80, 81, 82, 83, 84. 85, 8B, 87, 88, 89, 90, 91, 92, 93, 94, 95, 9B, 97, 98, 99, 10D or even more different artificial nucleic acids each encoding at least one different antigenic peptide or protein. Methods to produce polyvalent mRNA vaccines are disclosed in the PCT application PCT/EP20IB/082487.

D

Restriction site: A restriction site, also termed restriction enzyme recognition site, is a nucleotide sequence recognized by a restriction enzyme. A restriction site is typically a short, preferably palindromic nucleotide sequence, e.g. a sequence comprising 4 to 8 nucleotides. A restriction site is preferably specifically recognized by a restriction enzyme. The restriction enzyme typically cleaves a nucleotide sequence comprising a restriction site at this site. In a double-stranded nucleotide sequence, such as a5 double-stranded DNA sequence, the restrictioo enzyme typically cuts both strands of the nucleotide sequence. NA, mRNA: RNA is the usual abbreviation for ribonucleic-acid. It is a nucleic acid molecule, i.e. a polymer consisting of nucleotides. These nucleotides are usually adenosine-monophosphate, uridine-monophosphate, guanosine-monophosphate and cytidine-monophosphate monomers which are connected to each other along a so-called backbone. The backbone is formed by phosphodiester bonds between the sugar, i.e. ribose, of a first and a phosphate moiety of a second, adjacent monomer. The

5 specific succession of the monomers is called the RNA-sequence. Usually RNA may be obtainable by transcription of a DNA- sequence, e.g., inside a cell. In eukaryotic cells, transcription is typically performed inside the nucleus or the mitochondria. Typically, transcription of DNA usually results in the so-called premature RNA which has to be processed into so-called messenger-RNA, usually abbreviated as mRNA. Processing of the premature RNA, e.g. in eukaryotic organisms, comprises a variety of different posttranscriptional-modifications such as splicing. 5'-capping, polyadenylation, export from the nucleus or

ID the mitochondria and the like. The sum of these processes is also called maturation of RNA. The mature messenger RNA usually provides the nucleotide sequence that may be translated into an amino-acid sequence of a particular peptide or protein. Typically, a mature mRNA comprises a 5'-cap, a 5'-UTR, a coding region, a 3'-UTR and a poly(A) sequence. Aside from messenger RNA, several non-coding types of RNA exist which may be involved in regulation of transcription and/or translation.

I5 Stabilized nucleic acid, preferably mRNA: A stabilized nucleic acid, preferably mRNA typically, exhibits a modification increasing resistance to in vivo degradation (e.g. degradation by an BXO- or endo-nuclease) and/or ex vivo degradation (e.g. by the manufacturing process prior to vaccine administration, e.g. in the course of the preparation of the vaccine solution to be administered). Stabilization of RNA can, e.g., be achieved by providing a 5'-cap-Structure, a Poly-A-Tail, or any other UTR- modification. It can also be achieved by chemical modification or modification of the G/C content of the nucleic acid or other0 types of sequence optimization. Various other methods are known in the art and conceivable in the context of the invention.

Sequence identity: Two or more sequences are identical if they exhibit the same length and order of nucleotides or amino acids. The percentage of identity typically describes the extent, to which two sequences are identical, i.e. it typically describes the percentage of nucleotides that correspond in their sequence position with identical nucleotides of a reference sequence. In order5 to determine the degree of identity, the sequences to be compared are considered to exhibit the same length, i.e. the length of the longest sequence of the sequences to be compared. This means that a first sequence consisting of 8 nucleotides is 80% identical to a second sequence consisting of ID oucleotides comprising the first sequence. Hence, in the context of the present invention, identity of sequences preferably relates to the percentage of nucleotides of a seqoence which have the same position in two or more sequences having the same length. Therefore, e.g. a position of a first sequence may be compared with theD corresponding position of the second sequence. If a position in the first sequence is occupied by the same component (residue) as is the case at a position in the second sequence, the two sequences are identical at this position. If this is not the case, the sequences differ at this position. If insertions occur in the second sequence in comparison to the first sequence, gaps can be inserted into the first sequence to allow a further alignment. If deletions occur io the second sequence in comparison to the first sequence, gaps can be inserted into the second sequence to allow a further alignment. The percentage to which two seqoences5 are identical is then a function of the number of identical positions divided by the total number of positions including those positions which are only occupied in ooe sequence. The percentage to which two sequences are identical can be determined using a mathematical algorithm. A preferred, but not limiting, example of a mathematical algorithm which can be used is the algorithm of Karlin et al. ((903), PNAS USA, 90:5873-5877 or Altschul et al. (1997), Nucleic Acids Res., 25:3399-3402. Such an algorithm is integrated in the BLAST program. Sequences which are identical to the sequences of the present invention to a certain extent can be identified by this program.

5

Serotype, serotype of a virus: A serotype or a serotype of a virus is a group of viruses classified together based on their antigens on the surface of the virus, allowing the epidemiologic classification of organisms to the sub-species level.

Strain, strain of a virus: A strain or a strain of a virus is a group of viruses that are genetically distinct from other groups of the ID same species. The strain that is defined by a genetic variant is also defined as a "subtype".

Transfectian: The term "transfection" refers to the introduction of nucleic acid molecules, such as DNA or NA (e.g. mRNA) molecules, into cells, preferably into eukaryotic cells. In the context of the present invention, the term "transfection" encompasses any method known to the skilled person for introducing nucleic acid molecules into cells, preferably into eukaryotic 15 cells, such as into mammalian cells. Such methods encompass, for example, electroporation, lipofection, e.g. based on cationic lipids and/or liposomes, calcium phosphate precipitation, nanoparticle based transfection, virus based transfection, or transfection based on cationic polymers, such as DEAE-dextran or polyethylenimine etc. Preferably, the introduction of the nucleic acid, preferably the mRNA is non-viral. D Vaccine: A vaccine is typically understood tn be a prophylactic or therapeutic material providing at least one antigen, preferably an immunogen. The antigen or immunogen may be derived from any material that is suitable for vaccination. For example, the antigen or immunogen may be derived from a pathogen, such as from bacteria or virus particles etc., or from a tumor or cancerous tissue. The antigen or immunogen stimulates the body's adaptive immune system to provide an adaptive immune response.

5

Vector: The term "vector" refers to a nucleic acid molecule, preferably to an artificial nucleic acid molecule. A vector in the context of the present invention is suitable for incorporating or harboring a desired nucleic acid sequence, such as a nucleic acid sequence comprising a coding region. Such vectors may be storage vectors, expression vectors, cloning vectors, transfer vectors etc. A storage vector is a vector which allows the convenient storage of a nucleic acid molecule, for example, of an mRNAD molecule. Thus, the vector may comprise a sequence corresponding, e.g., to a desired mRNA sequence or a part thereof, such as a sequence corresponding to the coding region and the 3'-UTR and/or the 5'-UTR of an mRNA. An expression vector may be used for production of expression products such as RNA, e.g. mRNA, or peptides, polypeptides or proteins. For example, an expression vector may comprise sequences needed for transcription of a sequence stretch of the vector, such as a promoter sequence, e.g. an RNA polymerase promoter sequence. A cloning vector is typically a vector that contains a cloning site, which may be used5 to incorporate nucleic acid sequences into the vector. A cloning vector may be, e.g., a plasmid vector or a bacteriophage vector.

A transfer vector may be a vector which is suitable for transferring nucleic acid molecules into cells or organisms, for example, viral vectors. A vector in the context of the present invention may be, e.g., an RNA vector or a ONA vector. Preferably, a vector is a DNA molecule. Preferably, a vector in the sense of the present application comprises a cloning site, a selection marker, such as an antibiotic resistance factor, and a sequence suitable for multiplication of the vector, such as an origin of replication. Preferably, a vector in the context of the present application is a plasmid vector.

RNA in vitro transcription: The terms "RNA in vitro transcription" or "in vitro transcription" relate to a process wherein RNA is synthesized in a cell-free system (in vitro). DNA, particularly plasmid DNA, is used as template for the generation of RNA transcripts. RNA may be obtained by DNA-depeodent in vitro transcription of an appropriate DNA template, which according to the present invention is preferably a linearized plasmid DNA template. The promoter for controlling in vitro transcription can be any promoter for any DNA-dependent RNA polymerase. Particular examples of DNA-dependent RNA polymerases are the T7, T3, and SPG RNA polymerases. A DNA template for in vitro RNA transcription may be obtained by cloning of a nucleic acid, in particular cDNA corresponding to the respective RNA to be in vitro transcribed, and introducing it into an appropriate vector for in vitro transcription, for example into plasmid DNA. In a preferred embodiment of the present invention the DNA template is linearized with a suitable restriction enzyme, before it is transcribed in vitro. The cDNA may be obtained by reverse transcription of mRNA or chemical synthesis. Moreover, the DNA template for in vitro RNA synthesis may also be obtained by gene synthesis.

Methods for in vitro transcription are known in the art (see, e.g., Geall et al. (20I3) Semin. Immunol.25(2):I52-I59; Brunelle et al. (2DI3) Methods Enzymol. 530:I0I-I4). Reagents used in said method typically include:

1) a linearized DNA template with a promoter sequence that has a high binding affinity for its respective RNA polymerase such as bacteriophage-encoded RNA polymerases;

2) ribonucleoside triphosphates (NTPs) for the four bases (adenine, cytosine, guanine and uracil):

3) optionally a cap analogue as defined above (e.g. m7G(5')ppp(5')G (m7G)). optionally, fraction of NTPs optimized to the RNA sequence (according to WD/2DI5/I88933);

4) a DNA-dependent RNA polymerase capable of binding to the promoter sequence within the linearized DNA template (e.g.

T7, T3 or SPG RNA polymerase);

5) optionally a ribonuclease (RNase) inhibitor to inactivate any contaminating RNase;

G) optionally a pyrophosphatase to degrade pyrophosphate, which may inhibit transcription;

7) MgCI2, which supplies Mg2+ ions as a co-factor for the polymerase;

8) a buffer to maintain a suitable pH value, which can also contain antioxidants (e.g. DTT), and/or polyamines such as spermidine at optimal concentrations.

Vehicle: A vehicle is typically understood to be a material that is suitable for storing, transporting, and/or administering a compound, such as a pharmaceutically active compound. For example, it may be a physiologically acceptable liquid which is suitable for storing, transporting, and/or administering a pharmaceutically active compound.

Different species/species: The term "species" defines a monophyletic group of viruses whose properties can be distinguished from those of other species by multiple criteria (Adams et al., 2DI3, Arch Virol I58: 2633-9). The reference to a "different" or "2, 3, 4, 5, B, 7, 8, B, ID, II, 12, 13, 14, 15, IB, 17, 18, IB, 2B, 21, 22, 3, 24, 25, 2B, 27, 28, 23, 3D. 31, 32, 33, 34, 35, 3B, 37, 38, 30, 4D, 41, 2, 43, 44, 45, 4B, 47, 48, 9. 5D, 51. 52, 53, 54, 55, 5B, 57, 58, 5B, BD, Bl, B2, B3, B4, B5, BB, B7, B8, B9, 7D, 71, 72, 73, 74, 75, 7B. 77, 78, 79, 8D. 81. 82, 83, 84, 85, 8B, 87. 88, 89, 9D. 91, 92, 93, 94, 95, 9B, 97, 98, 99, IDD or more different" Gl, Gil, Gill, GIV Dr GV, Gl.l Dr GII.4 Nnrovirus or Noroviruses as used in the present invention means that a Norovirus from another species, strain 5 or serotype is used or that the properties of the Noroviruses which are used or utilized can be distinguished from those of the other Norovirus by multiple criteria.

^'-untranslated region (3'-DTR): Generally, the term "3'-DTR" refers to a part of the artificial nucleic acid molecule, which is located 3' (i.e. "downstream") of a coding region and which is not translated into protein. Typically, a 3'-UTR is the part of an

ID mRNA which is located between the protein coding region (coding region or coding sequence (CDS)) and the poly(A) sequence of the mRNA. In the context of the invention, the term 3'-DTR may also comprise elements, which are not encoded in the template, from which an RNA is transcribed, but which are added after transcription during maturation, e.g. a poly(A) sequence. A 3'-UTR of the mRNA is not translated into an amino acid sequence. The 3'-UTR sequence is generally encoded by the gene which is transcribed into the respective mRNA during the gene expression process. The genomic sequence is first transcribed into pre-

15 mature mRNA, which comprises optional introns. The pre-mature mRNA is then further processed into mature mRNA in a maturation process. This maturation process comprises the steps of 5'capping, splicing the pre-mature mRNA to excize optional introns and modifications of the 3'-end, such as polyadenylation of the 3'-end of the pre-mature mRNA and optional endo-/ or exonuclease cleavages etc. In the context of the present invention, a 3'-DTR corresponds to the sequence of a mature mRNA which is located between the stop codon of the protein coding region, preferably immediately 3' to the stop codon of the proteinD coding region, and the poly(A) sequence of the mRNA. The term "corresponds to" means that the 3'-DTR sequence may be an RNA sequence, such as in the mRNA sequence used for defining the 3'-DTR sequence, or a DNA sequence which corresponds to such RNA sequence. In the context of the present invention, the term "a 3'-DTR of a gene", is the sequence which corresponds to the 3'-DTR of the mature mRNA derived from this gene, i.e. the mRNA obtained by transcription of the gene and maturation of the pre-mature mRNA. The term "3'-DTR of a gene" encompasses the DNA sequence and the RNA sequence (both sense and antisense5 strand and both mature and immature) of the 3'-UTR. Preferably, the 3'-UTRs have a length of more than 2D, 3D, 40 or 50 nucleotides.

5'-untranslated region (S'-OTR): Generally, the term "5'-UTR" refers to a part of the artificial nucleic acid molecule, which is located 5' (i.e. "upstream") of a coding region and which is not translated into protein. A 5'-DTR is typically understood to be aD particular section of messenger RNA (mRNA), which is located 5' of the coding region of the mRNA. Typically, the 5'-UTR starts with the transcriptional start site and ends one nucleotide before the start codon of the coding region. Preferably, the 5'-UTRs have a length of more than 2D, 3D, 40 or 50 nucleotides. The 5'-UTR may comprise elements for controlling gene expression, also called regulatory elements. Such regulatory elements may be, for example, ribosomal binding sites. The 5'-UTR may be post transcriptionally modified, for example by addition of a 5'-CAP. A 5'-DTR of the mRNA is not translated into an amino acid5 sequence. The 5'-DTR sequence is generally encoded by the gene which is transcribed into the respective mRNA during the gene expression process. The genomic sequence is first transcribed into pre-mature mRNA, which comprises optional introns. The pre-mature mRNA is then further processed into mature mRNA in a maturation process. This maturation process comprises the steps of 5'capping, splicing the pre-mature mRNA to excize optional intrnns and modifications of the S'-end. such as polyadenylation of the S'-end of the pre-mature mRNA and optional endoV or exonuclease cleavages etc.. In the context of the present invention, a 5'-UTR corresponds to the sequence of a mature mRNA which is located between the start codon and, for

5 example, the 5'-cap. Preferably, the 5'-UTR corresponds to the sequence which extends from a nucleotide located 3' to the 5'- cap, more preferably from the nucleotide located immediately 3' to the 5'-eap, to a nucleotide located 5' tn the start codon of the protein coding region, preferably to the nucleotide located immediately 5' to the start codon of the protein coding region. The nucleotide located immediately 3' to the 5'-cap of a mature mRNA typically corresponds to the transcriptional start site. The term "corresponds to" means that the 5'-UTR sequence may be an RNA sequence, such as in the mRNA sequence used for defining

ID the 5'-UTR sequence, or a DNA sequence which corresponds to such RNA sequence. In the context of the present invention, the term "a 5'-UTR of a gene" is the sequence which corresponds to the 5'-DTR of the mature mRNA derived from this gene, i.e. the mRNA obtained by transcription of the gene and maturation of the pre-mature mRNA. The term "5'-UTR of a gene" encompasses the DNA sequence and the RNA sequence (both sense and antisense strand and both mature and immature) of the 5'-UTR.

I5 5'-Terminal Oligapyrimidine Tract (TDP): The 5'-terminal oligopyrimidine tract (TDP) is typically a stretch of pyrimidine nucleotides located in the 5'-terminal region of a nucleic acid molecule, such as the 5'-terminal region of certain mRNA molecules or the 5'-terminal region of a functional entity, e.g. the transcribed region, of certain genes. The sequence starts with a cytidine, which usually corresponds to the transcriptional start site, and is followed by a stretch of usually about 3 to 3D pyrimidine nucleotides. For example, the TDP may comprise 3, 4, 5, 6, 7. 8, B, ID, II, I2, 13, 14, I5, IB. I7, IS, IB, 2D, 21, 22, 23, 24, 25, 2B, 27, 28,D 29, 30 or even more nucleotides. The pyrimidine stretch and thus the 5' TOP ends one nucleotide 5' to the first purine nucleotide located downstream of the TDP. Messenger RNA that contains a 5'-terminal oligopyrimidine tract is often referred to as TDP mRNA. Accordingly, genes that provide such messenger RNAs are referred tn as TOP genes. TOP sequences have, for example, been found in genes and mRNAs encoding peptide elongation factors and ribosomal proteins. 5 TOP motif: In the context of the present invention, a TOP motif is a nucleic acid sequence which corresponds to a 5'TOP as defined above. Thus, a TDP motif in the context of the present invention is preferably a stretch of pyrimidine nucleotides having a length of 3-30 nucleotides. Preferably, the TOP-motif consists of at least 3 pyrimidine nucleotides, preferably at least 4 pyrimidine nucleotides, preferably at least 5 pyrimidine nucleotides, more preferably at least G nucleotides, more preferably at least 7 nucleotides, most preferably at least 8 pyrimidine nucleotides, wherein the stretch of pyrimidine nucleotides preferably starts0 at its 5'-end with a cytosine nucleotide. In TOP genes and TOP mRNAs, the TOP-motif preferably starts at its S'-end with the transcriptional start site and ends one nucleotide 5' to the first purin residue in said gene or mRNA. A TOP motif in the sense of the present invention is preferably located at the 5'-end of a sequence which represents a 5'-UTR or at the 5'-end of a sequence which codes for a 5'-DTR. Thus, preferably, a stretch of 3 or more pyrimidine nucleotides is called "TDP motif" in the sense of the present invention if this stretch is located at the 5'-end of a respective sequence, such as the artificial nucleic acid molecule,5 the 5'-0TR element of the artificial nucleic acid molecule, or the nucleic acid sequence which is derived from the 5'-0TR of a TOP gene as described herein. In other words, a stretch of 3 or more pyrimidine nucleotides, which is not located at the 5'-end of a 5'-UTR or a 5'-UTR element but anywhere within a 5'-UTR or a 5'-UTR element, is preferably not referred to as "TDP motif".

TDP gene: TDP genes are typically characterised by the presence of a 5'-terminal oligopyrimidine tract. Furthermore, most TOP genes are characterized by a growth-associated translational regulation. However, also TOP genes with a tissue specific translational regulation are known. As defined above, the 5'-0TR of a TOP gene corresponds to the sequence of a 5'-DTR of a mature mRNA derived from a TDP gene, which preferably extends from the nucleotide located 3' to the 5'-cap to the nucleotide located 5' to the start codon. A 5'-UTR of a TOP gene typically does not comprise any start codons, preferably no upstream AUGs (uAUGs) or upstream coding regions (uDRFs). Therein, upstream AUGs and upstream coding regions are typically understood to be AOGs and coding regions that occur 5' of the start codon (AOG) of the coding region that should be translated. The 5'-UTRs of TDP genes are generally rather short. The lengths of 5'-DTRs of TOP genes may vary between ZD nucleotides up to 5DD nucleotides, and are typically less than about 2D0 nucleotides, preferably less than about I5D nucleotides, more preferably less than about 100 nucleotides. Exemplary 5'-0TRs of TDP genes in the sense of the present invention are the nucleic acid sequences extending from the nucleotide at position 5 to the nucleotide located immediately 5' to the start codon (e.g. the ATG) in the sequences according to SED ID NQs: I-I3G3 of the patent application WO 2013/143700. whose disclosure is incorporated herewith by reference. In this context a particularly preferred fragment of a 5'-0TR of a TOP gene is a 5'-DTR of a TDP gene lacking the 5'TOP motif. The terms "5'-UTR of a TOP gene" or "5'-T0P UTR" preferably refer to the 5'-UTR of a naturally occurring TOP gene.

Qrtholoques and paraloques: Orthologues and paralogues encompass evolutionary concepts used to describe the ancestral relationships of genes. Paralogues are genes within the same species that have originated through duplication of an ancestral gene; orthologues are genes from different organisms that have originated through speciation, and are also derived from a common ancestral gene. In the context of the invention, an orthologue and/or a paralague of a Norovirus nucleic acid sequence of the invention preferably refers to a sequence having in increasing order of preference at least 50%, 51%, 52%, 53%, 54%. 55%, 56%. 57%, 58%, 59%. 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%. 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to the sequence as represented by SED 10 NOs: 4411-39690, 39713-39746. In the context of the invention, an orthologue and/or a paralague of a Norovirus amino acid sequence of the invention refers preferably to a sequence having in increasing order of preference at least 50%. 51%. 52%, 53%, 54%, 55%, 56%, 57%. 58%. 59%. G0%. 61%. 62%, 63%. 64%, 65%, 66%, 67%, 68%, 69%. 70%. 71%, 72%, 73%, 74%, 75%, 76%. 77%, 78%, 79%, 80%. 81%. 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% 90%. 91%, 92%, 93%. 94%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to the sequence as represented by SEQ 10 NOs: 1-4410.

Hybridization/Homoloqy: Nucleic acid molecules which are advantageously for the process according to the invention can be isolated based on their homology to the nucleic acid molecules or a complement sequence of the nucleic acid molecules disclosed herein using the sequences or part thereof as hybridization probe and following standard hybridization techniques under stringent hybridization conditions. In this context, it is possible to use, for example, isolated nucleic acid molecules of at least 15, 2D, 25, 3D, 35, 4D, 5D, BD or more nucleotides, preferably of at least 15, 20 or 25 nucleotides in length which hybridize under stringent conditions with the above-described nucleic acid molecules, in particular with those which encompass a nucleotide sequence of the nucleic acid molecule used in the invention or encoding a protein used in the invention or of the nucleic acid molecule of the invention. Nucleic acid molecules with 3D, 5D, IOD, 25D or more nucleotides may also be used.

5 The term "homology" means that the respective nucleic acid molecules or encoded proteins are functionally and/or structurally equivalent. The nucleic acid molecules that are homologous to the nucleic acid molecules described above and that are derivatives of said nucleic acid molecules are, for example, variations of said nucleic acid molecules which represent modifications having the same biological function, in particular encoding proteins with the same or substantially the same biological function. They may be naturally occurring variations, such as sequences from other species, strains, or mutations. These mutations may occur

ID naturally or may be obtained by mutagenesis techniques. The allelic variations may be naturally occurring allelic variants as well as synthetically produced or genetically engineered variants. Structurally equivalents can, for example, be identified by testing the binding of said polypeptide to antibodies or computer based predictions.

By "hybridizing" it is meant that such nucleic acid molecules hybridize under conventional hybridization conditions, preferably under stringent conditions such as described by, e.g., Sambrook (Molecular Cloning; A Laboratory Manual, 2nd Edition, Cold Spring 15 Harbor Laboratory Press, Cold Spring Harbor, NY (1989)) or in Current Protocols in Molecular Biology, John Wiley B Sons, N. Y.

(1989). 6.3.1-6.3.6.

According to the invention, DNA as well as NA molecules of the nucleic acid of the invention can be used as probes. Further, as template for the identification of functional homologues Northern blot assays as well as Southern blot assays can be performed. The Northern blot assay advantageously provides further information about the expressed gene product: e.g. expression pattern,D occurrence of processing steps, like splicing and capping, etc. The Southern blot assay provides additional information about the chromosomal localization and organization of the gene encoding the nucleic acid molecule of the invention.

A preferred, no limiting example of stringent hydridization conditions are hybridizations in B x sodium chloride/sodium citrate (= SSC) at approximately 45°C, followed by one or more wash steps in 0.2 x SSC, 0.1% SDS at 5D to B5°C, for example at 50 ^a C, 55 ^D C or BD°C. The skilled worker knows that these hybridization conditions differ as a function of the type of the nucleic acid5 and, for example when organic solvents are present, with regard to the temperature and concentration of the buffer. The temperature under "standard hybridization conditions" differs for example as a function of the type of the nucleic acid between 42°C and 58 ^D C, preferably between 45 ^D C and 5D ^D C in an aqueous buffer with a concentration of D.I x D.5 x, I x, 2x, 3x, 4x or 5 x SSC (pH 7.2). If organic solvent(s) is/are present in the abovementioned buffer, for example 50% formamide, the temperature under standard conditions is approximately 40 ^a C, 42 ^D C or 45 ^D C. The hybridization conditions for DNA:DNA hybrids are preferably0 for example 0.1 x SSC and 20 ^D C, 25 ^D C, 3D ^D C, 35 ^D C, 40°C or 45 ^D C, preferably between 30°C and 45 ⁿ C. The hybridization conditions for DNA:RNA hybrids are preferably for example 0.1 x SSC and 3D ^D C, 35°C. 4D°C, 45°C, 5D ^D C or 55°C, preferably between 45 ^D C and 55 ^D C. The abovementioned hybridization temperatures are determined for example for a nucleic acid approximately ID0 bp (= base pairs) in length and a G + C content of 50% in the absence of formamide. The skilled worker knows to determine the hybridization conditions required with the aid of textbooks, for example the ones mentioned above, or from the following5 textbooks: Sambrook et al., "Molecular Cloning", Cold Spring Harbor Laboratory, 1989 ; Hames and Higgins (Ed.) 1185, "Nucleic Acids Hybridization: A Practical Approach", IRL Press at Oxford University Press, Oxford ; Brown (Ed.) 1991, "Essential Molecular Biology: A Practical Approach", IRL Press at Oxford University Press, Oxford .

A further example of one such stringent hybridization condition is hybridization at 4XSSC at G5 ^D G, followed by a washing in O.IXSSC at G5°C for one hour. Alternatively, an exemplary stringent hybridization condition is in 50% formamide, 4XSSC at 42 ^D C. Further, the conditions during the wash step can be selected from the range of conditions delimited by low-stringency conditions (approximately 2X SSC at 50°C) and high-stringency conditions (approximately 0.2X SSC at 50 ^D C, preferably at B5 ^D C) (20X SSC: D.3M sodium citrate, 3M NaCI, pH 7.0). In addition, the temperature during the wash step can be raised from low-stringency conditions at room temperature, approximately 22°C, to higher-stringency conditions at approximately G5°C. Both of the parameters salt concentration and temperature can be varied simultaneously, or else one of the two parameters can be kept constant while only the other is varied. Denaturants, for example formamide or SDS, may also be employed during the hybridization. In the presence of 50% formamide, hybridization is preferably effected at 42 ^D C. Relevant factors like i) length of treatment, ii) salt conditions, iii) detergent conditions, iv) competitor DNAs, v) temperature and vi) probe selection can be combined case by case so that not all possibilities can be mentioned herein.

Some examples of conditions for DNA hybridization (Southern blot assays) and wash step are shown herein below:

(1) Hybridization conditions can be selected, for example, from the following conditions:

a) 4X SC at G5 ^D C,

b) BX SC at 45 ^D C,

c) GX SSC, 100 mg/ ml denatured fragmented fish sperm DNA at B8 ^D C,

d) GX SSC, 0.5% SDS, I0D mg/ml denatured salmon sperm DNA at 68 ^D C,

e) GX SSC, 0.5% SDS, 100 mg/ ml denatured fragmented salmon sperm DNA, 50% formamide at 42 ^D C, f) 50% formamide, 4X SSC at 42°C,

g) 50% (vol/ vol) formamide, 0.1% bovine serum albumin, 0.1% Ficoll, D.l% polyvinylpyrrolidone, 5D mM sodium phosphate buffer pH 6.5, 750 mM NaCI, 75 mM sodium citrate at 42 ^D C,

h) 2X or 4X SSC at 50°C (low-stringency condition), or

i) 3D to 40% formamide, 2X or 4X SSC at 42°C (low-stringency condition).

(2) Wash steps can be selected, for example, from the following conditions:

a) D.0I5 M NaCI/0.0015 M sodium citrate/0.1% SDS at 5D ^D C.

b) O.IX SSC at GS

c) O.IXSSC, 0.5% SDS at GB°C.

d) 0.IX SSC, 0.5% SDS, 50% formamide at 42°C.

e) 0.2X SSC, 0J% SDS at 2 ^D C.

f) 2X SSC at G5 ^D C (low-stringency condition).

Further, some applications have to be performed at low stringency hybridisation conditions, without any consequences for the specificity of the hybridisation. For example, a Southern blot analysis of total DNA could be probed with a nucleic acid molecule of the present invention and washed at low stringency (55 ^D C in 2xSSPE, 0,1% SDS). A further example of such low-stringent hybridization conditions is 4XSSC at 5D°C or hybridization with 3D to 40% formamide at 42 ^D C. Such molecules comprise those which are fragments, analogues or derivatives of the polypeptide of the invention or used in the methods of the invention and differ, for example, by way of amino acid and/or nucleotide deletion(s), insertion(s), substitution (s), addition(s) and/or recombination (s) or any other modification(s) known in the art either alone or in combination from the above-described amino acid sequences or their underlying nuclentide sequence(s). However, it is preferred to use high stringency hybridisation conditions.

Hybridization should advantageously be carried out with fragments of at least 5, 10, 15, 2D, 25, 30, 35 or 4D bp, advantageously at least 5D, BD, 7D or 80 bp, preferably at least 00, 100 or 110 bp. Most preferably are fragments of at least 15, 2D, 25 or 30 bp. Preferably are also hybridizations with at least IDD bp Dr 200, very especially preferably at least 400 bp in length. In an especially preferred embodiment, the hybridization should be carried out with the entire nucleic acid sequence with conditions described above.

The term "hybridizes under stringent conditions" is defined above. In one embodiment, the term "hybridizes under stringent conditions" is intended to describe conditions far hybridization and washing under which nucleotide sequences at least 30%, 40%, 50% or 65% identical to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences at least about 70%, more preferably at least about 75% or 80%. and even more preferably at least about 85%, B0% or 35% or more identical to each other typically remain hybridized to each other,

To determine the percentage homology (= identity, herein used interchangeably) of two amino acid sequences nr of two nucleic acid molecules, the sequences are written one underneath the other for an optimal comparison (for example gaps may be inserted into the sequence of a protein or of a nucleic acid in order to generate an optimal alignment with the other protein or the other nucleic acid).

The amino acid residues or nucleic acid molecules at the corresponding amino acid positions or nucleotide positions are then compared. If a position in one sequence is occupied by the same amino acid residue or the same nucleic acid molecule as the corresponding position in the other sequence, the molecules are homologous at this position (i.e. amino acid or nucleic acid "homology" as used in the present context corresponds to amino acid or nucleic acid "identity". The percentage homology between the two sequences is a function of the number of identical positions shared by the sequences (i.e. % homology = number of identical positions/total number of positions x 100). The terms "homology" and "identity" are thus to be considered as synonyms.

For the determination of the percentage homology (= identity) of two or more amino acids or of two or more nucleotide sequences several computer software programs have been developed. The homology of two or more sequences can be calculated with for example the software fasta, which presently has been used in the version fasta 3 ( W. R. Pearson and D. J. Lipman (1388), Improved Tools for Biological Sequence Comparison. PNAS 85:2444-2448; W. R. Pearson (1330) Rapid and Sensitive Sequence Comparison with FASTP and FASTA, Methods in Enzymology 183:63-38; W. R. Pearson and D. J. Lipman (1388) Improved Tools for Biological Sequence Comparison. PNAS 85:2444-2448; W. R. Pearson (1330); Rapid and Sensitive Sequence Comparison with FASTP and FASTAMethods in Enzymology 183:33-38). Another useful program for the calculation of homologies of different sequences is the standard blast program, which is included in the Biomax pedant software (Biomax, Munich, Federal Republic of Germany). This leads unfortunately sometimes to suboptimal results since blast does not always include complete sequences of the subject and the query. Nevertheless as this program is very efficient it can be used for the comparison of a huge number of sequences. The following settings are typically used for such a comparisons of sequences: -p Program Name [String]; -d Database [String]; default = nr: -i Query File [File In]; default = stdin; -e Expectation value (E) [Real]; default = 10.0; -m alignment view options: 0 = pairwise; I = query-anchored showing identities; 2 = query-anchored no identities; 3 = flat query-anchored, show identities; 4 = flat query-anchored, no identities; 5 = query-anchored no identities and blunt ends; B = flat query-anchored, no identities and blunt ends; 7 = XML Blast output: 8 = tabular; B tabular with comment lines [Integer]; default = 0; -o BLAST report Output File [File Out] Optional; default = stdnut; -F Filter query sequence (DUST with blastn, SEG with others) [String]; default = T; -G Cost to open a gap (zero invokes default behavior) [Integer]; default = 0; -E Cost to extend a gap (zero invokes default behavior) [Integer]; default = 0; -X X drop-off value for gapped alignment (in bits) (zero invokes default behavior); blastn 30, mega blast 20, tblastx 0, all others 15 [Integer]; default = 0; -I Show Gl's in deflines [T/F]; default = F; - q Penalty for a nucleotide mismatch (blastn only) [Integer]; default = -3; -r Reward for a nucleotide match (blastn only) [Integer]; default = I; - v Number of database sequences to show one-line descriptions for (V) [Integer]; default = 500; -b Number of database sequence to show alignments for (B) [Integer]; default = 250; -f Threshold for extending hits, default if zero; blastp II, blastn 0, blastx 12, tblastn 13; tblastx 13, mega blast 0 [Integer]; default = 0; -g Perfom gapped alignment (not available with tblastx) [T/F]; default = T; -0 Duery Genetic code to use [Integer]; default = I; -D DB Genetic code (for tblast[nx] only) [Integer]; default = I; -a Number of processors to use [Integer]: default = I; -0 SeqAlign file [File Out] Optional; -J Believe the query defline [T/F]; default = F: -M Matrix [String]; default = BL0SUMB2; -W Word size, default if zero (blastn II, megablast 28, all others 3) [Integer]; default = D; - z Effective length of the database (use zero for the real size) [Real]; default = 0; -K Number of best hits from a region to keep (off by default, if used a value of 100 is recommended) [Integer]; default = 0; -P 0 for multiple hit, I for single hit [Integer]; default = 0; -Y Effective length of the search space (use zero for the real size) [Real]; default = 0: -S Query strands to search against database (for blast[nx], and tblastx); 3 is both, I is top, 2 is bottom [Integer]; default = 3; -T Produce HTML output [T/F]; default = F; -I Restrict search of database to list of Gl's [String] Optional; -0 Ose lower case filtering of FASTA sequence [T/F] Optional; default = F; -y X dropoff value for ungapped extensions in bits (0.0 invokes default behavior); blastn 20, megablast 10, all others 7 [Real]; default = 0.0: -Z X dropoff value for final gapped alignment in bits (0.0 invokes default behavior); blastn/megablast 50, tblastx 0, all others 25 [Integer]; default = 0; -R PSI-TBLASTN checkpoint file [File In] Optional; -n MegaBlast search [T/F]; default = F; -L Location on query sequence [String] Optional; -A Multiple Hits window size, default if zeru (blastn/megablast D, all others 40 [Integer]; default = 0: -w Frame shift penalty (OOF algorithm for blastx) [Integer]; default = 0; -t Length of the largest intron allowed in tblastn for linking HSPs (0 disables linking) [Integer]; default = 0.

Results of high quality are reached by using the algorithm of Needleman and Wunsch or Smith and Waterman. Therefore programs based on said algorithms are preferred. Advantageously the comparisons of sequences can be done with the program PileUp ( J. Mol. Evolution., 25, 351 (1987), Higgins et al., CABI0S 5, 151 (1989)) or preferably with the programs "Gap" and "Needle", which are both based on the algorithms of Needleman and Wunsch (J. Mol. Biol. 48; 443 (1970)), and "BestFit", which is based on the algorithm of Smith and Waterman (Adv. Appl. Math. 2; 482 (1981 )). "Gap" and "BestFit" are part of the GCG software-package (Genetics Computer Group, 575 Science Drive, Madison, Wisconsin, USA 53711 (1991); Altschul et al., (Nucleic Acids Res. 25, 3389 (1937)), "Needle" is part of the European Molecular Biology Dpen Software Suite (EMBOSS) (Trends in Genetics IB (B), 27B (200D)). Therefore preferably the calculations to determine the percentages of sequence homology are done with the programs "Gap" or "Needle" over the whole range of the sequences. The following standard adjustments for the comparison of nucleic acid sequences were used for "Needle": matrix: EDNAFULL, Gapjenalty: ID.D, Extendjenalty: D.5. The following standard adjustments for the comparison of nucleic acid sequences were used for "Gap": gap weight: 5D, length weight: 3, average match: ID.DDD, average mismatch: D.DDD.

For example a sequence, which has 80% homology with sequence SED ID NO: 4411 at the nucleic acid level is understood as meaning a sequence which, upon comparison with the sequence SED ID ND: 4411 by the above program "Needle" with the above parameter set, has a 80% identity.

Homology between two polypeptides is understood as meaning the identity of the amino acid sequence over in each case the entire sequence length which is calculated by comparison with the aid of the above program "Needle" using Matrix: EBL0SUMG2, Gap_penalty: 8.D, Extend_penalty: 2.D.

For example a sequence which has a 80% homology with sequence SEQ ID NO: I at the protein level is understood as meaning a sequence which, upon comparison with the sequence SEQ ID NO: I by the above program "Needle" with the above parameter set, has a 80% identity. Detailed Description:

In a first aspect, the invention relates to an artificial nucleic acid comprising or consisting of at least one coding region encoding at least one polypeptide derived from a Norovirus, and/or a fragment or variant thereof. In another embodiment, the artificial nucleic acid comprises at least one coding region encoding at least one polypeptide comprising or consisting of at least one Norovirus capsid protein, and/ or a fragment or variant thereof.

In one embodiment, the artificial nucleic acid molecule according to the invention comprises at least one coding region encoding the Norovirus capsid protein VPI or VP2. In another embodiment, the artificial nucleic acid encodes Norovirus capsid protein VPI. In this context, a reference to a Norovirus capsid protein VPI equals a reference to a VPI capsid protein derived from a Norovirus, a Norovirus VPI, capsid protein, capsid protein VPI, major capsid protein, major capsid protein VPI, major capsid region, major viral capsid protein, or VPI capsid protein.

In particular, the invention relates to an artificial nucleic acid comprising or consisting of at least one coding region encoding at least one polypeptide selected from the group consisting of Norovirus capsid protein VPI (also termed "Major capsid protein" or "capsidprotein"), Norovirus capsid protein VP2 (also termed "Minor capsid protein") and/ or a Norovirus non-structural protein, such as NSI/NS2 (also termed p48 or Nterm (amino terminal protein)), NS3 (also termed NTPase or Nucleoside triphosphatase). NS4 (also termed p22 or 3A-like protein), NS5 (also termed VPg or Genome-linked viral protein), NSB (also termed Pro or Proteinase), or NS7 (also termed Pol or NA-dependent NA polymerase), and/or a fragment or variant of any of these proteins.

In one embodiment of the invention, vaccines and/or compositions contain VPI proteins and/or VP2 proteins. Preferably each vaccine and/or composition contains VPI and/or VP2 proteins from only one Norovirus genogroup giving rise to a monovalent vaccine. As used herein, the term "monovalent" means the antigenic proteins are derived from a single Norovirus genogroup. For example, the vaccines and/ or compositions contain VPI and/ or VP2 from a virus strain of genogroup I (e.g. VPI and VP2 from Norwalk virus). Preferably the vaccines and/ or compositions are comprised of predominantly VPI proteins. In one embodiment of the invention, the antigen is a mixture of monovalent vaccines and/or compositions wherein the composition includes vaccines and/or compositions comprised of VPI and/or VP2 from a single Norovirus genogroup mixed with vaccines and/or compositions comprised of VPI and/or VP2 from a different Norovirus genogroup taken from multiple viral strains (e.g. a Norovirus from Genogroup IV.2 and a Norovirus from Genogroup I.I). Purely by way of example the composition can contain monovalent vaccines and/ or compositions from one or more strains of Norovirus genogroup I together with monovalent vaccines and/ or compositions from one or more strains of Norovirus genagroup II. Preferably, the Norovirus vaccines and/ or composition mixture is composed of the Norovirus from Genogroup IV.2 and Norovirus from Genogroup 1.1 or from different genus or species of a Norovirus from Genogroup IV.2. Preferably the vaccines and/ or compositions are comprised of predominantly VPI proteins. In one embodiment of the invention, the antigen is a mixture of monovalent vaccines and/or compositions wherein the composition includes vaccines and/or compositions comprised of VPI and/or VP2 from a single Norovirus genogroup mixed with vaccines and/or compositions comprised of VPI and/or VP2 from a different Norovirus genogroup taken from multiple viral strains (e.g. a Norovirus from Genogroup 11.4 and a Norovirus from Genogroup I.I). Purely by way of example the composition can contain monovalent vaccines and/ or compositions from one or more strains of Norovirus genogroup I together with monovalent vaccines and/or compositions from one or more strains of Norovirus genogroup II. Preferably, the Norovirus vaccines and/or composition mixture is composed of the Norovirus from Genogroup 11.4 and Norovirus from Genogroup I.I or from different genus or species of a Norovirus from Genogroup 11.4. In this context, the amino acid seguence of the at least one antigenic peptide or protein may be selected from any peptide or protein derived from a capsid protein VPI, capsid protein VP2, NSI/NS2, NS3, NS4, NS5, NSB, or NS7 of a Norovirus or a fragment or variant thereof.

Further, in an alternative embodiment of the invention, the vaccines and/or compositions may be multivalent vaccines and/or compositions that comprise, for example, VPI and/or VP2 proteins from one Norovirus genogroup intermixed with VPI and/or VP2 proteins from a second Norovirus genogroup, wherein the different VPI and VP2 proteins are not chimeric VPI and VP2 proteins, but associate together within the same capsid structure to form immunogenic Vaccines and/or compositions. As used herein, the term "multivalent" mBans that the antigenic proteins are derived from two or more Norovirus genogroups. Multivalent vaccines and/ or compositions may contain vaccines and/ or composition antigens taken from two or more viral strains. Purely by way of example the composition can contain multivalent vaccines and/or compositions comprised of capsid monomers or 5 multimers from one or more strains of Norovirus genogroup I together with capsid monomers or multimers from one or more strains of Norovirus genogroup II. Preferably, the Norovirus vaccines and/ or composition mixture is composed of the Norovirus from Genogroup IV.2 and Narovirus from Genogroup I.I or from different genus or species of a Narovirus from Genogroup IV.2.

Further, in an alternative embodiment of the invention, the vaccines and/or compositions may be multivalent vaccines and/or ID compositions that comprise, for example, VPI and/or VP2 proteins from one Norovirus genogroup intermixed with VPI and/or VP2 proteins from a second Norovirus genogroup, wherein the different VPI and VP2 proteins are not chimeric VPI and VP2 proteins, but associate together within the same capsid structure to form immunogenic Vaccines and/or compositions. As used herein, the term "multivalent" means that the antigenic proteins are derived from two or more Norovirus genogroups. Multivalent vaccines and/or compositions may contain vaccines and/or composition antigens taken from two or more viral strains. Purely 15 by way of example the composition can contain multivalent vaccines and/or compositions comprised of capsid monomers or multimers from one or more strains of Norovirus genogroup I together with capsid monomers or multimers from one or more strains of Norovirus genogroup II. Preferably, the Norovirus vaccines and/or composition mixture is composed of the Norovirus from Genogroup 11.4 and Norovirus from Genogroup I.I or from different genus or species of a Narovirus from Genogroup 11.4. D In another embodiment, the artificial nucleic acid may comprise 2, 3, 4, 5, G, 7, 8, 9, ID or more coding regions encoding at least one polypeptide selected from the group consisting of Norovirus capsid protein VPI, Norovirus capsid protein VP2, NS1/NS2. NS3, NS4, NS5, NSB, or NS7, and/ or a fragment or variaot of any of these proteins.

In a preferred embodiment, the compositions or vaccines of the present invention comprise a multivalent vaccine, e.g.,5 comprising a polynucleotide which encodes at least two different VPI, for example a Norovirus capsid protein VPI from a GII.4 strain and a Norovirus capsid protein VPI from a Gl.l strain. In another embodiment, the compositions or vaccines comprises a multivalent vaccine, e.g., comprising two different polynucleotides, whereby one polynucleotide encodes for example a Norovirus capsid protein VPI from a GII.4 strain and the other polynucleotide encodes a Norovirus capsid protein VPI from a Gl.l strain. D In a further embodiment, the compositions or vaccines of the present invention may comprise a multivalent vaccine, e.g., comprising a polynucleotide which encodes at least two different VPI, for example a Norovirus capsid protein VPI from two different GII.4 strains. In another embodiment, the compositions or vaccines comprise a multivalent vaccine, e.g., comprising two different polynucleotides, whereby one polynucleotide encodes for example a Norovirus capsid protein VPI from two different GII.4 strains.

5 In some embodiments, as defined above, the composition or the vaccine is multivalent, i.e. compositions or vaccines of the present invention may vary in their valency. Valency refers to the number of antigenic components in the composition or vaccine. In some embodiments, the compositions or vaccines are monovalent. In some embodiments, the compositions or vaccines are divalent or bivalent. In some embodiments the compositions or vaccines are trivalent. In some embodiments the compositions or vaccines are teravalent. In some embodiments the compositions or vaccines are multi-valent. Multivalent vaccines may comprise at least 2, 3, 4, 5, G, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3B, 37. 38, 39, 40, 41, 2, 43, 44, 45. 4B. 47, 48, 49, 50. 51, 52, 53, 54, 55, 5B, 57, 58, 59, BO. Bl, B2, B3, B4, B5, BB, B7, B8, B9, 70, 71, 72, 73.74, 75, 7B. 77, 78. 79, 80, 81. 82, 83, 84, 85. 8B. 87, 88, 89, 90, 91, 92, 93, 94, 95, 9B, 97, 98, 99, 100 or more antigens or antigenic moieties (e.g., antigenic peptides, etc.). The antigenic components of the compositions or vaccines may be on a single polynucleotide or on separate polynucleotides. In another embodiment, multivalent vaccines may comprise or at least 10, 15, 20, 30. 40 or 50 or 100 or more antigens or antigenic moieties (e.g., antigenic peptides, etc.). In another embodiment, multivalent vaccines may comprise 2-10, 10-15, 15-20, 20-50, 50-100 or 100-200 or more antigens or antigenic moieties (e.g., antigenic peptides, etc.). In a preferred embodiment, the multivalent composition or vaccine comprises about 30 to about 5D antigens or antigenic moieties.

In some embodiments, the open reading frame of the one or more NA polynucleotides encodes at least 2, 3, , 5, G, 7, 8, 9 or 10 or at least 10, 15, 20 or 50 or 2-10, 10-15, 15-20, 20-50, 50-100 or 100-200 antigenic polypeptides.

In this context it is particularly preferred that the composition comprises at least two mRNA sequences, wherein at least one mRNA sequence encodes at least one antigenic peptide or protein, i.e. VPI, is derived from a GII.4 Norovirus and at least one mRNA sequence encodes at least one antigenic peptide or protein, derived from Norovirus VPI, is derived from another GII.4 Norovirus.

In another preferred embodiment each mRNA sequence encodes at least one different antigenic peptide or protein derived from proteins of different Noroviruses. Preferably each mRNA sequence encodes at least one antigenic peptide or protein, derived from Norovirus VPI, of different GII.4 Noroviruses or different Gl.l Noroviruses, or a combination thereof. In a further embodiment, the invention relates to a composition comprising or consisting of 2, 3, 4, 5, G, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25.2B.27, 28, 29, 30, 31. 32, 33, 34, 35, 3G, 37, 38, 39, 40, 1, 42, 43, 4, 45, 4B, 47, 48, 9, 50, 51, 52.53, 54. 55. 5B, 57. 58, 59, BD, Bl, B2. G3, G4, B5. BB. G7, B8, B9, 70, 71, 72, 73, 74, 75, 7B, 77, 78, 79, 80, 81, 82, 83, 84, 85, 8B, 87, 88, 89, 90, 91, 92, 93, 94, 95, 9B, 97, 98, 99, 100 or more separate artificial nucleic acids selected from the group of SEQ ID NOs: 4411-39690. 397I3-3974B comprising at least one coding region encoding at least one polypeptide derived from a Norovirus selected from the group SEQ ID NOs: 1-4410 or a fragment or variant of any of these proteins. In some embodiments, the open reading frame of the one or more RNA polynucleotides encode at least I0, 15, 2D, 3D, 40 or 5D or IDD antigenic polypeptides. In some embodiments, the open reading frame nf the one or more RNA polynucleotides encode 2- ID, ID-I5. 15-2D, 20-5D, 5D-IDD or I00-2D0 antigenic polypeptides.

5 The present invention is based on the surprising finding that the at least one Norovirus protein comprised in the at least one polypeptide encoded by the artificial nucleic acid as described herein can efficiently be expressed in a mammalian cell. It was further unexpectedly found that the artificial nucleic acid is suitable for eliciting an immune response against Norovirus in a subject.

ID Furthermore, the present invention is based on the surprising finding that mRNA-based or artificial nucleic acid vaccines comprising mRNA nr artificial nucleic acid sequences encoding different antigens of a Norovirus (particularly Norovirus capsid protein VPI) were extremely effective in inducing an antigen-specific immune response against Norovirus. Furthermore, the inventors surprisingly found that many mRNA sequences encoding different antigens of different Noroviruses can be effectively combined in ooe mRNA-based vaccine.

I5

In one embodiment, the artificial nucleic acid of the invention comprises at least one coding region encoding at least one polypeptide derived from a Norovirus and/or a fragment or variant thereof.

In a further embodiment, the artificial nucleic acid of the invention comprises at least one coding region encoding at least one0 polypeptide selected from the group consisting of a non-structural protein derived from a Norovirus and/or a capsid protein derived from a Norovirus, and/ or a fragment or variant thereof.

In a further embodiment, the artificial nucleic acid of the invention comprises at least one coding region encoding at least one polypeptide selected from the group consisting of Norovirus non-structural proteins NSI/NS2, NS3, NS4, NS5, NSB, NS7,5 Norovirus capsid protein VPI and Norovirus capsid protein VP2, and/ or a fragment or variant thereof.

Norovirus:

In the context of the present invention, the term "Norovirus" comprises any Norovirus, irrespective of strain or origio. Preferably, the term "Norovirus" comprises a Norovirus strain selected from the group consisting of Genogroup I, Genogroup II, Genogroup0 III, Genogroup IV, or Genogroup V (abbreviated as Gl, Gil, Gill, GIV or GV. respectively).

In a further embodiment, the term "Norovirus" comprises a Norovirus strain selected from the group consisting of

(i) Genogroup I genotype I (abbreviated as Gl.l), GI.2, GI.3, GI.4, GI.5, GI.G, GI.7, GI.8, GI.9. GI.IO, GUI, GI.I2, GI.I3. GI.I4, GI.I5.

GI.IG and/or GI.I7;

5 (it) Genogroup II genotype I (abbreviated as Gll.l), GII.2, GII.3. GII.4, GII.5, GII.G, GII.7, GII.8, GII.9. GII.IO, Gll.ll. GII.I2. GII.I3,

GII.I4. GII.I5, GII.IG. GII.I7, GII.IB. GII.IO, GII.20, GII.2I, GII.22, GII.23, and/or GII.24; (iii) Genogroup II! genotype I (abbreviated as Glll.l), GIII.2, GIII.3, and/or GIII.4;

(iv) Genogroup IV genotype I (abbreviated as GIV.I). GIV.2, GIV.3, and/or GIV.4;

(v) Genogroup V genotype I (abbreviated as GV.I), GV.2, GV.3. and/or GV.4;

and/ or combinations of 2, 3, 4, 5, G, 7.8.9, or 10, or more of any of the above Noroviruses from different Genogroups and/ or 5 different Genotypes,

In a further embodiment, the nucleic acid of the invention, preferably a VPI nucleic acid derived from a Norovirus, is derived from a Norovirus selected from the group consisting of

(i) Genogroup I genotype I (abbreviated as Gl.l), GI.2, GI.3, GI.4, GI.5, GI.G, GI.7. GI.B. GI.B, GI.IO, GUI. GI.I2. GI.I3. GI.I4, GI.I5, ID GLIB and/or GI.I7;

(ii) Genogroup II genotype I (abbreviated as Gll.l), GII.2, GII.3, GII.4, GII.5, GII.G, GII.7, GII.8, GII.9, GII.ID, Gll.ll. GII.I2, GII.I3.

GII.I4. GII.I5. GII.IG, GII.I7. GIU8, GII.I9, GII.2Q, GII.2I. GII.22, GII.23, and/or GII.24:

(iii) Genogroup III genotype I (abbreviated as Glll.l), GIII.2, GIII.3, and/or GIII.4;

(iv) Genogroup IV genotype I (abbreviated as GIV.I), GIV.2, GIV.3, and/or GIV.4; and

15 (v) Genogroup V genotype I (abbreviated as GV.I), GV.2, GV.3, and/ or GV.4.

In the case, 2, 3, 4. 5, B. 7, 8, 3, ID or more different VPI nucleic acids are utilized nr employed, for example in a composition of the invention or a vaccine of the invention, the VPI nucleic acids can be derived from 2, 3, , 5, B, 7, 8, B, or IQ, or more of any of the above Noroviruses from different Genogroups and/or different Genotypes.

D

In the context of the invention, a reference to Gl.l to GI.I7 means a reference to Gl.l, GI.2, GI.3, GI.4. GI.5, GI.B, GI.7, GI.8, GI.B, GI.IO, GUI, GI.I2, GI.I3, GI.I4, GI.I5, GLIB and/or GI.I7; a reference to Gll.l to GII.24 means a reference to Gll.l, GII.2, GII.3, GII.4, GII.5, GII.G. GII.7, GII.8. GII.9, GII.ID, Gll.ll, GII.I2, GII.I3, GII.I4, GII.I5. GII.IG. GII.I7, GII.IB. GII.I9, GII.2D, GII.ZI. GII.22, GII.23. and/or GII.24; a reference to Glll.l to GIII.4 means to a reference to Glll.l, GIII.2, GIII.3, and/or GIII.4; a reference to GIV.I to GIV.4 means to a5 reference to GIV.I, GIV.2, GIV.3, and/or GIV.4; a reference to GV.I to GV.4 means to a reference to GV.I, GV.2, GV.3, and/or GV.4.

In other embodiments, the term "Norovirus" comprises a Norovirus strain selected from the group consisting of a GII.4 Norovirus and/or a Gl.l Norovirus. In a further embodiment, the term "Norovirus" as used herein refers to Norovirus GII.4 CIN-I (also termed Norovirus Hu/GII.4/D3IB33/USA/2DD3 or having Accession No. JD3B58ID.I), GII.4 (Accession No; AY5D2D23.I), GII.4 CIN-0 D02 and/ or GII.4 Sydney. In another embodiment, the Norovirus is a GII.4 Sydney Norovirus or a GII.4 Sydney 2DI2 Norovirus.

In other embodiments, the term "Norovirus" comprises a Norovirus strain selected from the group consisting of a GII.4 Norovirus and/or a Gl.l Norovirus. In a further embodiment, the term "Norovirus" as used herein refers to Norovirus GII.4-03IG93-USA- 2D03, Norovirus GII.4/Farmington Hills/20D2/DSA, Norovirus Gll.4-2006b 092895-0-2008, Norovirus GII.4-GZ20I0-L87-5 Guangzhou-2011, Norovirus GII.4-USA-I997, Norovirus GU-OSA-IGBB-Capsidprotein. In another embodiment, the term "Norovirus" comprises a Norovirus strain selected from the group consisting of Norovirus Hu/GII.4/Dijon/E872/2DD2/F A. Norovirus Hu/GII.4/MDI2D-l2/ie87/USA, Norovirus Hu/GIIJ/7EK/Hawaii/l97l/USA, Norovirus Hu/GII.B/CHDC4073/I984/USA, Norovirus Hu/GII.4/Hiroshima/IB/2G0l/JPN, Norovirus Hu/GII.4/Hiroshima/67/2DDG/JPN. Norovirus Hu/GII/JP/2DI5/GII.Pe_GII.4/0saka/0SF78, Norovirus GII/Hu/NL/2DI2/GII.4/Groningen, Norovirus GII/Hu/NL/2DI4/GII.2/Groningen. Norovirus Hu/GII.4/New 0rleansl5DD/2D08/USA, Norovirus Hu/GII.B/0hio/49D/2D!2/USA. Norovirus Hu/GII.3/Jingzhou/2DI3402/CHN. Norovirus Hu/GII.4/Jingzhou/2DI34D3/CHN, Norovirus Hu/GII.I7/Gaithersburg/2D14/US, Norovirus Hu/GII.4/CI27/GF/l978, Norovirus Hu/GII.4/CHDC39G7/l988/US, Norovirus Hu/GII.4/CH0C4ID8/l887/US. Norovirus Hu/GII.4/CHDC487l/l977/US. Norovirus Hu/GII.3/CHDC526l/l990/US, Norovirus Hu/GII.3/ ilwaukee009/20IO/USA, Norovirus Hu/GII.4/Miranda/NSW8l7L/20!0/AU. Norovirus Hu/Gll.2/KLI09/ Y/I978, Norovirus Hu/GII.I4/HK74/CN/l978, Nurovirus Hu/Gll.7/HK4/CN/I97B. Norovirus Hu/GII.I7/C!42/GF/l978. Norovirus Hu/GII.5/CI5/GF/l978. Norovirus Hu/GI.5/E57/UG/!B75, Norovirus Hu/GII.4/ andwick/NSW882J/20ll/AU, Nurovirus Hu/GII.4/Berowra/NSW7G7L/2DI2/AU, Norovirus Hu/GII.4/Sydney/NSW05l4/2DI2/AU, Norovirus Hu/GII.4/Hong ong/CUHK3B30/20I2/CHN, Norovirus Hu/GII.4/VPII72/Shanghai/2DI2/CHN. Norovirus Hu/GII-4/New Taipei/CGMHGI/2DI2/TW. Norovirus GII/Hu/HKG/2DI3/GII.4/CUHK-NS-l4l, Norovirus GII/Hu/JP/20D2/GII.PI2_GII.I3/Saitama/T8D. Norovirus GII/Hu/JP/20DI/GII.PI2_GII.I2/Saitama/TI5. Norovirus GII/Hu/JP/20D7/GII.P2l_GII.2l/, Kawasaki/Y0284, Norovirus GII/Hu/JP/2DD7/GII.PI5_GII.I5/ Sapporo/HK299, Norovirus GI/Hu/JP/2DD7/GI.P3_GI.3/Shimizu/KK28GB. Norovirus GII/Hu/JP/2DD7/GII.P7_GII.I4/Fukuoka/KK282, Norovirus GI/Hu/JP/2DD7/GI.P8_GI.8/Nagoya/ Y53l. Norovirus Hu/GI /SJTUHI/CHN/2014, Norovirus Hu/GII.4/variant Sydney 2DI2/FRA. Norovirus Hu/GII-4/Hokkaido4/2DDB/JP, Norovirus GIV/Hu/Jp/2DDI/GIV.I/DCDIDI7023. Nurovirus Hu/GII.4/Beijing/53B7l/2007/CHN, Norovirus Hu/ll.4/220DBBI/H /20IO, Norovirus Hu/GII.4/Aichi3B8-!4/20l4, Norovirus Hu/GII.4/Hunter 284E/040/AU, Norovirus Hu/GII-4/0saka/l398/JPN. Norovirus

Hu/GI.I/P774.Delsjo2004/Gothenburg/Sweden, Norovirus pig/Gll.lt/FI8-ID/2DD5/CAN, Norovirus

Hu/Gll.4/Wellington/I995/OSA. Norovirus Hu/GII.4/Henry/2000/OSA, Norovirus Hu/GII.4/SSCS/2005/USA, Norovirus GII/Hu/IN/200B/GII.P4_GII.4_ Yerseke200Ba/Pune-PC2l, Norovirus Hu/GI.I/P7-587/2007/Stromstad/Swed.n, Norovirus Hu/GI.2/Leuven/2003/BEL Nurovirus Hu/GII.7/NSW743L/2008/AUS. Norovirus Hu/GII.2/NF20D2/USA/2Q02, Norovirus Hu/GII.4/NF2003/USA/2D03, Norovirus Hu/GII.3/1999, Norovirus Hu/GIV.I/Ahrenshoop24B/DEU/20l2, Norovirus Hu/GII.4/Xi'an/PI9/20IO/CHN. Nurovirus Hu/GII.4/PA3G3/20ll/ITA. Norovirus Hu/Gll.4/P3/20I2/Gothenburg/Sweden. Norovirus Hu/GII.4/Tanger/T G87/20ll/MAR. Norovirus t2-X-2/20l2/GII.P22/GII.5. Norovirus Hu/GII.4/Kobe034/200G/JP. Norovirus Hu/GGII.4/TiBl00l/l995/NL. Norovirus Hu/GGII.4/DenHaagOI5/2000/NL. Norovirus Hu/GGII.4/SchiedamOI8/200l/NL, Norovirus Hu/GGII.4/Apeldoorn023/2003/NL Norovirus

Hu/GGII.4/ iddelburg007/20D4/NL, Norovirus Hu/GII-4/Matsudo/02l07l/2D02/JP, Norovirus Hu/GII- 4/ aiso/03055B/2003/JP. Norovirus Hu/GII-4/Awa/040354/2004/JP, Norovirus Hu/GII.4/Apeldoorn317/2007/NL, Norovirus Hu/GII.2/Rotterdam39E/2002/NL. Norovirus Hu/GII.4/RotterdamP200/2005/NL, Norovirus Hu/Gll.4/Stockholm/I98B5/2008/SE. Norovirus Hu/GII.B/DC040B2VLP/2004/JP, Norovirus Hu/GII.4/HSI94/2DD9/US. Norovirus Hu/GII.I2/HS2IO/20IO/OSA, Norovirus Hu/GI.I/8Flla/l9G8/0SA. Norovirus Hu/Gll.4/CHDC5I9I/I974/USA, Norovirus Hu/GII.4/N7G/20!0/HuZhou. Norovirus Hu/GII.B/S9c/I97G/SEN. Norovirus Hu/GII L45/I978/MYS. Norovirus Hu/GII.4/NIHICI7.5/2DIZ/USA. Norovirus Hu/GII.4/NIHIC9/20ll/DSA, Norovirus Hu/Gll.4/Cll0/I378/GUF, Norovirus Hu/GII.4/HSBB/200l/USA. Norovirus Hu/GII/JP/2DI5/GII.PI7_GII.I7/Kawasaki3DB. Norovirus

Hu/GII/JP/2DI4/GII.PI7_GII.I7/NaganoB-l, Norovirus Hu/GII/JP/2DI5/GII.PE_GII.4/Dsaka/DSF7B. Norovirus GI/Hu/NL/2Qtl/GI.4/Groningen, Norovirus Gll/Hu/NL/20I4/Gll.4/Groningen0i, Norovirus

5 Hu/GII.4/KanBpupu/NZ327/20DB/NZL. Norovirus Hu/GII.4/ athminas/NSW2B7R 2D07/AUS. Norovirus Hu/GII.4/Turramurra/NSW8B2U/2DD9/AUS, Norovirus Hu/GII.4/Seoul/0389/2009/K0R, Norovirus HU/GII.4/SBDUI/0B45/2DQ9/KGR. Norovirus Hu/GIU2/Shelby/2D09/DSA, Norovirus Hu/GI.7/TCH-OGD/USA/2003, Norovirus Hu/GII.I/Ascension2D8/2DI0/USA, Norovirus Hu/GII.I3/VAI73/2DI0/USA, Norovirus Hu/GII.2l/Salisburyl50/20ll/DSA. Norovirus Hu/Gll.4/I997/USA, Norovirus Hu/GII.4/Farmington Hills/2BD4/USA, Norovirus Hu/GII.4/MinervB/2D0B/USA,

ID Norovirus Hu/GII.4/Dhio/7l/2DI2/USA, Norovirus Hu/GII.4/AlbertaEIDB5/2DII/CA. Norovirus Hu/GII.4/SG4D5l-D9/2DD9/SG.

Norovirus Hu/GII.3/TCH-ID4/USA/2QD2, Norovirus Hu/GI.G/TCH-D99/USA/2DD3, Norovirus 06-AM- tt/2DDB/GII.4/Yerseke 20D6B. Norovirus D9-BI-2/2DD9/GII.4/Ne DrlBans/2D0B. Norovirus Hu/GII.4/PR328/2DI3/ITA, Norovirus Hu/GII.PI7_GII.I7/PRBB8/2DI5/ITA, Norovirus Hu/GII.4/Alb _E rtaSPI/2DI3/CA, Norovirus HU/GII.4/CDDDD7BB2 2DII/UK. Norovirus Hu/GII.6/GZ20IO-LB6/Guangzhou/CHN/2DII. Norovirus Bo/GIII.I/Aba-

15 Z5/ZDD2/HUN, Norovirus GI.3, Norovirus Hu/GII.I7/CDHK-NS-B70/HKG/2D15, Norovirus GII/Hu/SI/2DI5/GIIJ7/LjubljanalBB2, Norovirus Hu/Gll.l7/CDH -NS-B47/HKG/2D15, Norovirus Hu/GII.2l/CUHK-NS-GD9/HKG/2DI5. Norovirus Hu/GII.4/MBlbournBBB23/2DIB/AUS, Norovirus GII/Hu/JP/2DIB/GII.PIB_GII.4_ SydnBy2DI2/DHIB002, Norovirus Hu/GII/JP/20IB/GII.PIB_GII.4_ SydnBy2DI2/ awasakil94. Norovirus IBF2l49_GII.2_Guangdong_CHN_2DIB, Norovirus Hu/GII.I7/CUH -NS-8B4/H G/2DIB. Norovirus GII/Hu/ZAF/2D12/GII.P4_GII.4/ CapeTown/9772, Norovirus GII.I2, Snow Nountain D virus. Human calicivirus strain Melksham.

In ΟΠΒ Bmbodiment, the artificial nucleic acid is derived from a Norovirus selected from the group consisting of genogroup I Norovirus, genogroup II Norovirus, genogroup III Norovirus, gBnogroup IV Norovirus, and genogroup V Norovirus; preferably the artificial nucleic acid is derived frrnn a Norovirus selscted from the group consisting of a Gl.l to GI.I7 Norovirus, Gll.l to GII.24 5 Norovirus, Glil.l to GIII.4 Norovirus. GIV.I to GIV.4 Norovirus and GV.I to GV.4 Norovirus; more prefErably. the artificial nucleic acid is derived from a Norovirus selected from the group consisting of Gl.l Norovirus and GII.4 Norovirus, even ΓΠΟΓΒ preferably, the artificial nucleic acid is derived from a GII.4 Norovirus, still more preferably, the artificial nucleic acid is derived from a GII.4 CIN-I Norovirus or a GII.4 Sydney Norovirus or a GII.4 Sydney 2DI2 Norovirus. D In preferred embodimBnts, the artificial nucleic acid is derived from a Norovirus selected from the group consisting of Norovirus GII.4-03IB93-USA-2D03, Norovirus GIU/Farmington Hills/2DD2/DSA, Norovirus GII.4-2DDBb 0928B5-DSA-2008, Norovirus GII.4-GZ2DI0-L87-Guangzhou-2DII. Norovirus GII.4-USA-I997, Norovirus GI.I-DSA-l9G8-Capsidprotein.

Norovirus peptides or protBins:

35 The at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises at least one Norovirus protein. The RNA genome of Norovirus typically encodes a plurality of structural and non-structural proteins. Translation of Norovirus RNA typically leads to a precursor protein comprising a plurality of individual viral (structural and nonstructural) proteins (or precursor of these proteins) in one polypeptide chain, which is typically referred to as "polyprotein" or "precursor protein". In the context of the present invention, a Norovirus polyprotein typically comprises amino acid sequences that are target sites for enzymes that specifically cleave the polyprotein in order to yield fragments of the polyprotein, wherein the fragments preferably comprise an individual Norovirus protein or two or more Norovirus proteins, or a fragment or variant thereof. In the context of the present invention, the term "polyprotein" may also refer to a polypeptide chain comprising the amino acid sequences of at least two individual Norovirus proteins, or a fragment or variant thereof. Cleavage of a Norovirus polyprotein preferably occurs between individual Norovirus proteins (e.g. between the capsid protein VPI and the capsid protein VP2, or fragments or variants thereof. An individual Norovirus protein, or a fragment or variant thereof, e.g. as obtained from a polyprotein by cleavage, is preferably referred to as "mature Norovirus protein". In the context of the present invention, the term "mature Norovirus protein" is not limited to an individual Norovirus protein, or a fragment or variant thereof, which was generated by cleavage of a polyprotein, but also comprises an individual Norovirus protein of another origin, such as an individual Norovirus protein expressed recombinantly from an artificial nucleic acid. Preferably, a mature Norovirus protein lacks an amino acid sequence that is typically present in a corresponding amino acid sequence encoding said Norovirus protein in a Norovirus polyprotein (precursor protein) and wherein said amino acid sequence lacking in the mature Norovirus protein preferably corresponds to an amino acid sequence, which is usually removed by cleavage during processing of a Norovirus polyprotein. For example, an amino acid sequence, which is a target site for a protease, may be present in a Norovirus polyprotein, but may be absent from a mature Norovirus protein derived from said Norovirus polyprotein.

In one embodiment, the artificial nucleic acid comprising at least one coding region encoding at least one polypeptide comprises at least one Norovirus capsid protein VPI or Norovirus capsid protein VP2 and/or a fragment or a variant thereof. In another embodiment, the artificial nucleic acid comprising at least one coding region encoding at least one polypeptide comprises at least one Norovirus capsid protein VPI and/ or a fragment or variant thereof. In a further embodiment, the artificial nucleic acid comprises a Norovirus capsid protein VPI and/or a fragment or variant thereof.

In the context of the present invention, the term "Norovirus protein" may refer to any amino acid encoded by a Norovirus nucleic acid. In the context of the invention, a Norovirus capsid protein VPI or VPI protein is preferred. For example, a "Norovirus protein" may be any polypeptide comprising or consisting of an amino acid sequence according to any one of the following amino acid sequences from Genbank, or a fragment or variant of any of these sequences as provided in Table I (Column 2: "NC8I or Genbank Accession No.") and Table 3 (Column 2; "NCBI or Genbank Accession No."). In particular, the term "Norovirus protein" as used herein comprises an individual structural or non-structural Norovirus protein. For example, a Norovirus protein in the meaning of the present invention may be a protein selected from the group consisting of Norovirus capsid protein VPI. Norovirus capsid protein VP2. and a Norovirus non-structural protein (NS). such as NSI/NS2, NS3, NS4, NS5, NSB, or NS7.

In particular, the term "Norovirus protein" as used herein is a Norovirus capsid protein VPI. Further, in particular, the term "Norovirus protein" as used herein is a Norovirus capsid protein derived from a GII.4 Norovirus.

As used herein, the term "Norovirus protein" may also refer to an amino acid sequence corresponding to an individual Norovirus protein as present in a Norovirus polyprotein (precursor protein). Said amino acid sequence in the polyprotein may differ from the amino acid sequence of the corresponding amino acid sequence of the respective mature Norovirus protein (i.e. after cleavage/processing the polyprotein). For example, the corresponding amino acid sequence comprised in the polyprotein may comprise amino acid residues that are removed during cleavage/processing of the polyprotein (such as a signal sequence or a target site for a protease) and that are no longer present in the respective mature Norovirus protein. In the context of the present invention, the term "Norovirus protein" comprises both, the precursor amino acid sequence comprised in a Norovirus polyprotein (i.e. as part of a polypeptide chain optionally further comprising other viral proteins) as well as the respective mature individual Norovirus protein. For example, the term "Norovirus capsid protein VPI" as used herein may refer to an amino acid sequence in a Norovirus polyprotein corresponding to the precursor sequence of Norovirus capsid protein VPI (comprising, for example, a (C-terminal) signal sequence) as present in a Norovirus polyprotein as well as to a mature (separate) Norovirus capsid protein VPI (no longer comprising, for example, a (C-terminal) signal sequence). Where reference is made to amino acid residues and their position in a Norovirus protein or in a Norovirus polyprotein, any numbering used herein - unless stated otherwise - relates to the position of the respective amino acid residue in a Norovirus polyprotein (precursor protein), wherein position "I" corresponds to the first amino acid residue, i.e. the amino acid residue at the N-terminus of a Norovirus polyprotein. More preferably, the numbering with regard to amino acid residues refers to the respective position of an amino acid residue in a Norovirus polyprotein, which is preferably derived from a Norovirus strain selected from the group consisting of Genogroup II Dr Genogroup I (abbreviated as Gil, or Gl, respectively), more preferably from the group consisting of Genogroup II genotype 4 (abbreviated as GII.4) or Genogroup I genotype I (abbreviated as GII.4 and Gl.l), or even more preferably the strain is selected from strain Norovirus strain GII.4 CIN-I or CIN-DD2.

Preferred Norovirus protein in the context of the invention may be any polypeptide comprising or consisting of an amino acid sequence according to any one of the following amino acid sequences from Genbank, or a fragment or variant of any of these sequences: AC0550B8, AFS33552, AFS33555, AFX7IGB5, BAI49904, BAI4B9I4, BAS02D83, CRL4G958, CRL4B973, ADB27D27, AGI9B397, AGXDI095, AGX0I098, A I300B0, AGL984I3, ACT7BI45, ACT7BI48, ACT7BI5I, AED02034, AEXI0549, AFJ2I448, AFN0B72B, AFN0B727, AFN0B73I, AFNDB732, AFN0B733, AFN0B735, AFV0877I, AFV08777, AFV08795, AFX95940, AGI99552, AGK25912, AI0B858I, AII737I7, AII73735, AII7374I, AII73759, AII737B5, AII73780, AII73783, AIS400I9, AIY27747, BAG70437, BAUIB30B, ACY00BI5, AD 47I70, BAQ2080I, AAZ3I37B, ABI9798I, ABW74I28, ACCB9D23, ACL272B7, ACL272B8, ACL272B9, ACL3I322, ACN32270, ACU5G258, ACX858I0, AFBI80I0, AFBI80I3, AFK75854, AFNBI3I5, AF0005II, AHCI2G55, AHZI29I2, AIC32559, AI05I48B, BAF458GI. BAF745D8, BAF74509, BAF745I2, BAF745I7, BAF745ZI, BAF95499, BAF955DI. BAFB55D5, BAG55289, BAGG87I3, BAGB88DI, BAH30707, BAL4D873. ADB279I4, ADT7BB84, AFJ385IB, AFJ385I9, AFWI5943, AGE99599, AGE99GI2, AGTI7839, AFX7IBB9. AGE99B07, AHI59IBB, BA 4229D. BA B3722, BASD2D84, CRL4B953, CRL4B9B2, ABDB3283, ACWI9927, ADQ43783. ADV37805, ADV379I9, AEI834G9, AEQ77282, AFA55I74, AFC89B5B, AFC89BG5, AFJG47D7, AFJD47D8. AFJ04709, AFP89593. 5 AFU5573I. AFU927IQ, AGDB4D38. AGTG252I. AJZ77BB4, AJZ77DI5, A E3I8GI, ALDD9BI8. ALT54494, CCX28BI9. AGC9B535, ABYB7257, AHA9IB5B, T3I57I8. T59I50I. KT3I57QB, R9ZI940. KX7B7083, LCI53I2I. LCI754B8. KY485I25, KU55584I. KP784B96, KP064D99. U7BD59, X8I879.

PrefErrEd examples of Noraviruses which may be used for providing the nucleic acid molecules of the invention may include IB Norovirus GII.4-03IB93-USA-ZBB3. Norovirus GII.4/Farmington Hills/ZBBZ/USA, Norovirus GII.4-ZB06b B9Z895-USA-ZBB8.

Norovirus GII.4-GZZBI0-L87-Guangzhou-ZDII. Norovirus GII.4-USA-I997. Norovirus GI.I-USA-I9B8.

Further Preferred examples of Noroviruses which may be used for providing the nuclEic acid molecules of the invention may include Norovirus Hu/GII.4/Dijon/E87Z/ZD02/FRA, Norovirus Hu/Gll.4/NDI2D-I2/I987/USA, Norovirus

15 Hu/GII.I/7EK/Hawaii/IB7l/USA. Norovirus Hu/GII.B/CHDC4D73/I984/USA, Norovirus Hu/Gll.4/Hiroshima/I9/ZBOI/JPN.

Norovirus Hu/GII.4/Hiroshima/B7/2GBB/JPN. Norovirus Hu/GII/JP/2BI5/GII.Pe_GII.4/Dsaka/DSF78. Norovirus GII/Hu/NL/2DI2/GIL4/Groningen, Norovirus GII/Hu/NL/2B!4/GII.2/Groningen. Norovirus Hu/GII.4/New Drleansl5DD/2DD8/USA, Norovirus Hu/GII.G/Ohio/490/2012/USA. Norovirus Hu/Gll.3/Jingzhou/20I3402/CHN, Norovirus Hu/GII.4/Jingzhou/2DI34D3/CHN. Norovirus Hu/GII.I7/Gaithersburg/20l4/US, Norovirus Hu/GII.4/CI27/GF/l978. NorovirusD Hu/GII.4/CHDC39G7/l988/US, Norovirus Hu/GII.4/CHDC4ID8/l987/US, Norovirus Hu/GII.4/CHDC487l/l977/US, Norovirus Hu/GII.3/CHDC52BI/l99Q/US, Norovirus Hu/GII.3/Milwaukee009/ZDI0/USA. Norovirus Hu/GII.4/ iranda/NSW8l7L/2DID/AU, Norovirus Hu/GII.Z/KLID9/MY/l978, Norovirus Hu/GIf.14/HK74/CN/J97S. Norovirus Hu/Gll.7/H 4/CN/I97B, Norovirus Hu/GII.I7/CI42/GF/l978. Norovirus Hu/GII.5/CI5/GF/l978. Norovirus Hu/Gl.5/E57/UG/I975, Norovirus Hu/GII.4/Randwick/NSW882J/2QII/AU, Norovirus Hu/GII.4/BBrowra/NSW7G7L/2DI2/AU, Norovirus5 Hu/GII.4/Sydney/NSWB5l4/2DI2/AU. Norovirus Hu/GII.4/Hong ong/CUHK3B3D/2DI2/CHN, Norovirus Hu/GII.4/VPII72/Shanghai/2DI2/CHN. Norovirus Hu/GII-4/New Taipei/CGMH6l/2DI2/TW. Norovirus GII/Hu/HKG/2DI3/GII.4/CUHK-NS-l4l, Norovirus GII/Hu/JP/2DDZ/GII.PIZ_GII.I3/Saitama/T8D, Norovirus GII/Hu/JP/2DDI/GII.PI2_GII.IZ/Saitama/TI5, Norovirus GII/Hu/JP/ZBD7/GII.P2l_GII.2l/, awasaki/YDZ84. Norovirus GII/Hu/JP/ZDD7/GII.PI5_GII.I5/ Sapporo/H Z99, Norovirus GI/Hu/JP/20D7/GI.P3J3l.3/Shimizu/KK28BB. NorovirusD GII/Hu/JP/Z007/GII.P7_GII.I4/Fukuoka/ KZ8Z. Norovirus GI/Hu/JP/Z0D7/GI.P8_GI.8/Nagoya/KY53l, Norovirus Hu/GII.4/SJTDHI/CHN/ZDI4, Norovirus Hu/GII.4/variant Sydney Z0I2/FRA, Norovirus Hu/GII-4/Hokkaido4/ZDDB/JP. Norovirus GIV/Hu/Jp/2DDI/GIV.I/OCOIOI7D23, Norovirus Hu/GII.4/Beijing/53G7l/2DD7/CHN. Norovirus Hu/ll.4/220DBGI/HK/2DI0. Norovirus Hu/GII.4/Aichi3B8-l4/20l4, Norovirus Hu/Bfl.4/Hunter 284E/D4D/AD. Norovirus Hu/GII-4/Dsaka/l998/JPN, Norovirus Hu/GI.I/P774.Delsjo20D4/Gothenburg/Sweden, Norovirus pig/GII.II/FI8-IO/2D05/CAN, Norovirus5 Hu/GII.4/Wellington/l995/USA, Norovirus Hu/GI /h y/ZOOO/DSA, Norovirus Hu/GII.4/SSCS/2DD5/USA. Norovirus GII/Hu/IN/2DDG/GII.P4 GII.4 YErseke2DDBa/Pune-PC2l, Norovirus Hu/GI.I/P7-587/20D7/Stromstad/Sweden. Norovirus Hu/GI.2/LeuvEn/2003/BEL Norovirus Hu/GII.7/NSW743L/ZD08/AUS. Norovirus Hu/GII.2/NF2DD2/USA/2002, Norovirus Hu/Gli.4/NF2DD3/USA/20D3, Norovirus Hu/BII.3/1399. Norovirus Hu/GIV.!/AhrBnshoop24G/0EU/20l2, Norovirus Hu/GII.4/XiWPI9/20IO/CHN, Norovirus Hu/GII.4/PA3G3/2DII/iTA, Norovirus Hu/GH.4/P3/ZDIZ/Gothenburg/SwedBn. Norovirus Hu/BII.4 Tanger/TM687/2D(f/MAR. Norovirus I2-X-2/20I2/GII.P22/GII.5, Norovirus Hu/GII.4/ obBQ34/2DDG/JP. Norovirus Hu/GGII.4/Ti _E ID0l/l995/NL. Norovirus Hu/GGII.4/DenHaagOI5/200Q/NL. Norovirus Hu/GGII.4/SchiedamDI8/2DDl/NL, Norovirus Hu/GGII.4/Apeldoorn023/2003/NL, Norovirus

Hu/GGII.4/MiddelburgDD7/2Q04/NL, Norovirus Hu/GII-4/Matsudo/Q2l07l/2Q02/JP, Norovirus Hu/GII- 4/Kaiso/D3D55G/2QD3/JP, Norovirus Hu/GII-4/Awa/04D354/2G04/JP, Norovirus Hu/GII.4/Apeldoorn3l7/2Q07/NL, Norovirus Hu/GII.2/Rotterdam39E/2002/NL, Norovirus Hu/GII.4/RottBrdamPZD0/2005/NL Norovirus Hu/GII.4/StDckholm/l98B5/2D08/SE. Norovirus Hu/GII.G/DC04DB2VLP/2DD4/JP. Norovirus Hu/GII.4/HSI94/2QD9/US. Norovirus Hu/GII.I2/HS2ID/20tO/USA, Norovirus Hu/GI.I/8Flla/l9B8/USA, Norovirus Hu/Gll.4/CHDC5I9I/I974/USA, Norovirus Hu/GII.4/N7B/2DID/HuZhou. Norovirus Hu/GII.B/S9c/I97B/SEN, Norovirus Hu/Gll.4/ L45/I97B/MYS. Norovirus Hu/GII.4/NIHICI7.5/2DI2/USA, Norovirus Hu/GII.4/NIHIC9/2DII/USA, Norovirus Hu/Gll.4/Cl!0/I978/GUF, Norovirus Hu/GII.4/HSBB/2DDI/USA. Norovirus Hu/GII/JP/2DI5/GII.PI7_GII.I7/ awasaki3D8. Norovirus Hu/GII/JP/2DI4/GII.PI7_GII.I7/Nagano8-l. Norovirus Hu/GII/JP/2DI5/GII.Pe_GII.4/Dsaka/0SF78. Norovirus GI/Hu/NL/20ll/GI.4/GroningBn. Norovirus GII/Hu/NL/20l4/GII.4/GroniogEnDI. Norovirus

Hu/BII.4/Kenepuru/NZ327/2DDB/NZL. Norovirus Hu/GI /Rathmines/NSW287R/2007/A0S, Norovirus Hu/GII.4/Turramurra/NSW892U/20D9/AUS, Norovirus HU/GII.4/SEOUI/0389/2D09/KDR, Norovirus Hu/GII.4/Seoul/0945/2D09/ DR, Norovirus Hu/GII.I2/Shelby/2009/LISA. Norovirus Hu/GI.7/TCH-DBD/USA/2003, Norovirus Hu/Gll.t/Ascension208/20IO/USA, Noravirus Hu/GII.I3/VAI73/20ID/USA. Norovirus Hu/GII.2l/Salisburyl50/20tl/USA. Norovirus Hu/Gll.4/I997/USA, Norovirus Hu/Gli.4/Farmiogton Hills/20D4/USA, Norovirus Hu/GII,4/ ioErvs/2006/USA, Norovirus Hu/GII.4/Dhio/7l/2DI2/USA. Noravirus Hu/GII.4/AlbertaEI065/20ll/CA, Noravirus Hu/GII.4/SG4D5l-09/2DD9/SG, Noravirus Hu/GII.3/TCH-IQ4/USA/2DD2. Norovirus Hu/GI.B/TCH-099/USA/2D03, Norovirus 06-AM- ll/2DDG/GII.4 YBPSBke/2DDGa. Norovirus 09-BI-2/2D09/Bli.4/NewQHeans/2D09. Norovirus Hu/Gll.4/PR32B/20I3/ITA. Norovirus Hu/GII.PI7_GII.I7/PRBB8/20I5/ITA, Noravirus Hu/GII.4/AlbBrtaSPI 20l3/CA. Norovirus HU/GII.4/CBD007B92/2DII/UK. Norovirus Hu/GII.B/GZ2DID-L9B/Guangzhou/CHN/2DII, Norovirus Bo/GIII.I/Aba- Z5/2QD2/HUN. Norovirus GI.9, Norovirus Ho/GII.!7/CUH -NS-G70/HKG/2D15, Norovirus GII/Hu/SI/2DI5/GII.I7/LiubljanalGB2. Norovirus Hu/GII.I7/CUH -NS-G47/H B/2DI5. Norovirus Hu/GII.2l/CUHK-NS-B09/HKG/2DI5. Norovirus Hu/BII.4/MelbourneBB23/2DIB/AUS. Noravirus GII/Hu/JP/2DIG/GII.PIG_GII.4_ Sydney2D12/0HfBDD2, Norovirus Hu/GII/JP/20IG/GII.PIB_GII.4_ Sydney20l2/Kawasakil94, Norovirus IGF2l49_GII.2_Guangdong_CHN_20IG. Norovirus Hu/GII.I7/C0H -NS-8G4/HKG/20IB, Norovirus Gll/Hu/ZAF/20I2/GII.P4_GII.4/ CapBTowo/9772. Norovirus GII.I2, Snow Mountain virus. Human calicivirus strain Mslksham.

Preferred ExamplBS of NorovirusBS which may be used for providing the nucleic acid molecules of the invention are provided in Table I (Column B "Strain/Isolate"). Even morB preferred examples of Noroviruses which may be used for providing the nuc!eic acid molecules af the invention are provided in Table 3 (Column I "Strain/Isolate"). The nucleic acid and corresponding amino acid sequences of each are all incorporated by reference in their entirety. In some embodiments, a cryptogram can be used for identification purposes and is organized: host species from which the virus was isolated/genus abbreviation/species abbreviation/strain name/year of occurrence/country of origin. (Green et al., Human Caliciviruses, in Fields Virology Vol. I 841-874 (Knipe and Howley, editors-in-chief, 4th ed„ Lippincott Williams S Wilkins 2001)). Use of a combination of Norovirus genogroups such as a genogroup I.I (Norwalk virus) and 11.4 (f.e. Houston virus) or other commonly circulating strains, or synthetic constructs representing combinations or portions thereof are preferred in some embodiments. New strains of Noroviruses are routinely identified (Centers for Disease Control, Morbidity and Mortality Weekly Report, 56(33):842-846 (2007)) and consensus sequences of two or more viral strains may also be used to express Norovirus antigens.

In some embodiments described herein, the at least one polypeptide encoded by the at least one coding region of the artificial nucleic acid may consist of an individual Norovirus protein, the amino acid sequence of which does typically not comprise an N- terminal methionine residue. It is thus understood that the phrase "polypeptide consisting of Norovirus protein ..." relates to a polypeptide comprising the amino acid sequence of said Norovirus protein and - if the amino acid sequence of the respective Norovirus protein does not comprise such an N-terminal methionine residue - an N-terminal methionine residue.

Norovirus sequences:

According to a preferred embodiment, the inventive artificial nucleic acid comprises at least one coding region encoding at least one polypeptide comprising or consisting of at least one Norovirus protein as described herein, wherein the at least one Norovirus protein comprises an amino acid sequence according to any one of SEQ 10 NOs: 1-4410, or a fragment or variant of any of these sequences.

In one embodiment, the term "sequence", "sequence of the invention", "artificial nucleic acid" or "artificial nucleic acid of the invention" refers to any one of SEQ ID NOs: I-39B90, 337I3-3B746.

In a further embodiment, the artificial nucleic acid of the invention comprises at least one encoded polypeptide comprising

(i) at least one of the amino acid sequences according to any one of SEQ 10 NOs: 1-4410; and/ or

(ii) at least one of the amino acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 50%, 57%, 58%, 58%, 80%, 81%, 82%, 83%, 84%, 85%, 66%, 87%, 88%, 83%, 70%, 71%, 72%, 73%,

74%, 75%, 78%, 77%, 78%, 78%, 80%, 81%, 82%, 83%, 84%, 85%, 88%, 87%, 88%, 88%, 80%, 81%, 82%, 83%, 94%, 35%, 96%, 97%, 98%, or 99% sequence identity to the amino acid sequence represented by any one of SEQ ID NOs: 1-4410; and/or

(iii) an orthologue or a paralogue of any one of SEQ ID NOs: 1-33890, 39713-39748; and/ or a fragment or variant of any of these sequences. In another embodiment the artificial nucleic acid of the invention comprises at least one coding region comprising

(i) at least one of the nucleic acid sequences according to any one of SEQ ID NOs: 44II-396B0, 337I3-3374B; and/ or

(ii) at least one of the nucleic acid sequences having, in increasing order of preference, at least 50%. 51%, 52%, 53%, 54%, 55%, 56%. 57%, 58%, 50%, 60%. 61%, 62%, 63%. 64%, 65%, 66%, 67%, 68%, 60%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 70%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 8B%, 00%, 91%, 92%, 93%, 94%, 95%, 9B%, 97%, 98%, or 99% sequence identity to the nucleic acid sequence represented by any one of SEQ ID NOs: 4411-39690. 39713-39746; and/or

(iii) at least one complement of the nucleic acid sequences which are capable of hybridizing with a nucleic acid sequence comprising a sequence as shown in SEQ ID NOs: 4411-39690, 39713-39746, and/or to a nucleic acid encoding a polypeptide having a sequence as shown in SEQ ID NOs: 1-4410, and/or

(iv) an orthologue or a paralogue of any one of SEQ ID NOs: 1-30690, 39713-39746: and/ or a fragment or variant of any of these sequences.

In the context of the present invention a fragment of a protein or a variant thereof encoded by the at least one coding sequence of the artificial nucleic acid according to the invention may typically comprise an amino acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with an amino acid sequence of the respective naturally occurring full-length protein or a variant thereof, preferably as disclosed in Table I, column I. column 2 or column 3, more preferably as disclosed in Table 3, column I, column 2, column 3.

In a preferred embodiment, the at least one coding sequence of the artificial nucleic acid sequence according to the invention preferably encodes Norovirus proteins selected from the proteins provided in Table I, or a fragment or variant thereof. Any Norovirus protein provided in Table I, or any a fragment or variant thereof, can cause an immune response when administered to an individual. Therefore, all Norovirus proteins provided in Table I and Table 3 can be considered as preferred Norovirus antigens in the context of the present invention.

It is further preferred that the at least one coding sequence of the artificial nucleic acid sequence of the present invention encodes a Norovirus protein or peptide, or a fragment or variant thereof, wherein the Norovirus protein or peptide is an antigen selected from the antigens listed in Table I. Therein, each row (row I - row 4410) corresponds to a Norovirus protein or antigen as identified by the respective gene name (first column, column I "Name") and the database accession number of the corresponding protein (second column, column 2 "NCBI or Genbank Accession No."). The third column, column 3 ("A") in Table I indicates the SED ID NOs corresponding to the respective amino acid sequence as provided herein. The SEQ ID NOs corresponding to the nucleic acid sequence of the wild type nucleic acid sequence encoding the Norovirus protein or peptide is indicated in the fourth column, column 4 ("B"), The fifth column, column 5 ("C") provides the SEQ ID NOs corresponding to modified nucleic acid sequences of the nucleic acid sequences as described herein that encode the Norovirus protein or peptide preferably having the amino acid sequence as defined by the SED ID NDs indicated in the third column ("A") or by the database entry indicated in the second column ("NCBI or Denbank Accession No.").

In this context it is further preferred that the at least one coding sequence of the artificial nucleic acid sequence of the present 5 invention encodes at least one Nnrovirus protein or peptide which is derived from Norovirus polyprotein, or a fragment or variant thereof, wherein the Norovirus polyprotein is selected from the Nnrovirus polyprotein amino acid sequences listed in Table I. Therein, each row corresponds to a Norovirus polyprotein as identified by the respective gene name (first column "Name", derived from NCBI or Genbank) and the database accession number of the corresponding protein (second column "NCBI or Benbank Accession No."). The third column ("A") in Table I indicates the SED ID NDs corresponding to the respective amino acid ID sequence as provided herein. The SED ID NDs corresponding to the nucleic acid sequence of the wild type nucleic acid encoding the Norovirus protein or peptide is indicated in the fourth column ("B"). The fifth column ("C") provides the SED ID NDs corresponding to modified nucleic acid sequences of the nucleic acids as described herein that encode the Norovirus protein or peptide preferably having the amino acid sequence as defined by the SEQ ID NDs indicated in the third column ("A") or by the database entry indicated in the second column ("NCBI or Genbank Accessioo No.").

I5

Particularly preferred in this context are the Norovirus polyprotein and nucleic acid sequences according to SEQ ID NDs: 397I3- 3374G.

In specific embodiments the Norovirus protein or peptide is derived from a Norovirus capsid protein VPI according to SEQ IDD NOs: 1-4410.

In this context it is further preferred that the at least one coding sequence of the artificial nucleic acid sequence of the present invention encodes at least one Norovirus protein or peptide which is derived from Norovirus capsid protein VPI, Dr a fragment or variant thereof, wherein the Norovirus capsid protein VPI is selected from the Norovirus capsid protein VPI amino acid5 sequences listed in Table I. Therein, each row corresponds to a Norovirus capsid protein VPI as identified by the respective gene name (first column "Name") and the database accessinn number of the corresponding protein (second column "NCBI or Genbank Accession No"). The third column ("A") in Table I indicates the SEQ ID NDs corresponding to the respective amino acid sequence as provided herein. The SED ID NDs corresponding to the nucleic acid sequence of the wild type RNA encoding the Norovirus antigen is indicated in the fourth column ("B"). The fifth column ("C") provides the SED ID NDs corresponding to modified nucleicD acid sequences of the RNAs as described herein that encode the Norovirus antigen preferably having the amino acid sequence as defined by the SEQ ID NDs indicated in the third column ("A") or by the database entry indicated in the second column ("NCBI or Genbank Accession No").

According to a preferred embodiment, the inventive artificial nucleic acid comprises or consists of at least one coding sequence5 encoding at least one Norovirus protein or peptide as described herein. Preferably, the inventive artificial nucleic acid comprises or consists of a coding sequence according to any one of SEQ ID NOs: 44II-3BG9D. 39713-30746, or a homolag, fragment or variant of any of these sequences (see Table I, column "B" and "C").

Accordingly, in another embodiment, a nucleic acid molecule of the invention is at least 15, 2D, 25 or 30 nucleotides in length. 5 Preferably, it hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of the nucleic acid molecule of the present invention or used in the methods of the present invention. The nucleic acid molecule is preferably at least 20, 30, 50, IDD, 250 or more nucleotides in length.

In a preferred embodiment, the present invention thus provides artificial nucleic acid sequences comprising at least one coding ID sequence, wherein the coding sequence encoding Norovirus capsid protein VPI comprises or consists any one of the nucleic acid sequences defined in Table I, preferably in the fourth or fifth column (column "B" or "C", respectively) of Table I, or a fragment or variant of any one of these sequences.

In particularly preferred embodiments the nucleic acid sequence comprises or consists of at least one coding sequence encoding 15 Norovirus capsid protein VPI according to SEQ ID NDs: 4411-39690, 39713-39746.

In these context it is particularly preferred that the nucleic acid sequence according to the invention comprises at least one coding sequence encoding Norovirus capsid protein VPI comprising a nucleic acid sequence selected from sequences being identical or at least 50%. 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, orD 99% identical to the nucleic acid sequences as disclosed in Table I, preferably in the fourth or fifth column (column "B" or "C", respectively) of Table I or a fragment or variant thereof.

According to a particularly preferred embodiment, the present invention provides an nucleic acid sequence as defined herein comprising at least one coding sequence encoding at least one Norovirus peptide or protein derived from Norovirus capsid5 protein VPI, wherein the coding sequence comprises or consists of any one of the (modified) nucleic acid sequences defined in the Column "C" of Table I, or of a fragment or variant of any one of these sequences.

According to a preferred embodiment, the inventive artificial nucleic acid comprises or consists of at least one coding sequence encoding at least one Norovirus protein or peptide as described herein, wherein the at least one Norovirus protein comprises0 an amino acid sequence according to any one of SEQ ID NDs: 1-4410, or a homolog, fragment or variant of any of these sequences (see Table I, third column, column "A"). According to a preferred embodiment, the inventive artificial nucleic acid comprises at least one coding sequence encoding at least one protein or peptide derived from a Norovirus, or a fragment Dr variant thereof, wherein the Norovirus protein or peptide preferably comprises or consists of any one of the amino acid sequences defined in the third column (column "A") of Table I, or a fragment or variant of any one of these sequences. In other words, the at least one5 coding sequence preferably encodes a Norovirus protein comprising or consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-4410. In a further preferred embodiment, the at least one coding sequence of the nucleic acid sequence according to the invention comprises or consists of an nucleic acid sequence identical to or having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, G0%, 70%, 80%, 85%, 86%, 87%, 88%, 83%, 80%, 91%. 02%. 93%. 94%, 95%. 9G%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with any one of the (G/C modified) NA sequences defined in the fifth column (column "C") of Table I, or of a fragment or variant of any one of these sequences.

In a further preferred embodiment, the at least one coding sequence of the nucleic acid sequence according to the invention comprises or consists of an nucleic acid sequence identical to or having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%. preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with any one of the (human codon usage adapted) RNA sequences defined in the fifth column (column "C") of Table I, or of a fragment or variant of any one of these sequences.

According to a particularly preferred embodiment, the at least one coding sequence of the RNA sequence according to the invention comprises or consists of an nucleic acid sequence having a sequence identity of at least 80% with any one of the (human codon usage adapted) RNA sequences defined in the fifth column (column "C") of Tables I, or of a fragment or variant of any one of these sequences.

According to a particularly preferred embodiment, the present invention provides an nucleic acid sequence as defined herein comprising at least one coding sequence encoding at least one Norovirus peptide or protein derived from Norovirus capsid protein VPI, wherein the coding sequence comprises or consists of any one of the (human codon usage adapted) RNA sequences defined in the fifth column (column "C") of Table I, or of a fragment or variant of any one of these sequences.

Norovirus peptide or protein derived from Norovirus capsid protein VPI, wherein the coding sequence comprises or consists of any one of the (codon optimized) RNA sequences defined in the fifth column (column "C") of Table I, or of a fragment or variant of any one of these sequences. Accordingly, in another embodiment, a nucleic acid molecule of the invention is at least 15, 20, 25 or 30 nucleotides in length. Preferably, it hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of the nucleic acid molecule of the present invention or used in the methods of the present invention, e.g. comprising the sequence shown in SEQ 10 NOs: 4411-39690, 39713-39746. The nucleic acid molecule is preferably at least 20. 30, 50, 100, 250 or more nucleotides in length. In one Embodiment of the invention, a complement sequence derived from SEQ 10 NDs: 4411-39690, 39713-39746, or a fragment or variant thereof is used in the hybridization. Preferably, a complement of a nucleic acid molecule of the invention that hybridizes under stringent conditions to a sequence shown in SEQ ID NDs: 4411-39690. 39713-39746 correspond to a naturally-occurring nucleic acid molecule of the invention. As used herein, a "naturally-occurring" nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein).

In a further preferred embodiment, the at least one coding sequence of the nucleic acid sequence according to the invention comprises or consists of an nucleic acid sequence identical to or having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%. 80%, 85%, 86%, 87%, 88%, 89%, 90%. 91%, 92%, 93%, 94%, 95%, 96%, 97%, 88%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with any one of the (codon optimized) RNA sequences defined in the fifth column 5 (column "C") of Table I, or of a fragment or variant of any nne of these sequences.

In the context of the present invention, a "fragment" of an amino acid sequence, such as a polypeptide or a protein, e.g. the at least one Norovirus protein as described herein, may typically comprise a sequeoce of a protein or peptide as defined herein, which is, with regard to its amino acid sequence (or the respective coding nucleic acid molecule), N-terminally and/or C- terminally truncated compared to the amino acid sequence of the original (native) protein (or respective coding nucleic acid molecule). Such truncation may thus occur either on the amino acid level or correspondingly on the nucleic acid level. A sequence identity with respect to such a fragment as defined herein may therefore preferably refer to the entire protein or peptide as defined herein or to the entire (coding) nucleic acid molecule of such a protein or peptide.

Preferably, a fragment of an amino acid sequence comprises or consists of a continuous stretch of amino acid residues corresponding to a continuous stretch of amino acid residues in the protein the fragment is derived from, which represents at least 5%, 10%, 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, and most preferably at least 8D% of the total (i.e. full-length) protein, from which the fragment is derived.

In the context of the present invention, a fragment of a protein or of a peptide may furthermore comprise a sequence of a protein or peptide as defined herein, which has a length of for example at least 5 amino acids, preferably a length of at least 6 amino acids, preferably at least 7 amino acids, more preferably at least 8 amino acids, even more preferably at least 9 amino acids: even more preferably at least 10 amino acids: even more preferably at least II amino acids: even more preferably at least 12 amino acids: even more preferably at least 13 amino acids: even more preferably at least 14 amino acids: even more preferably at least 15 amino acids: even more preferably at least 16 amino acids: even more preferably at least 17 amino acids: even more preferably at least 18 amino acids; even more preferably at least 19 amino acids; even more preferably at least 20 amino acids; even more preferably at least 25 amino acids; even more preferably at least 30 amino acids; even more preferably at least 35 amino acids; even more preferably at least 50 amino acids; or most preferably at least ID0 amino acids. For example such fragment may have a length of about 6 to about 2D or even more amino acids, e.g. fragments as processed and presented by MHC class I molecules, preferably having a length of about 8 to about ID amino acids, e.g. 8, 9, or ID, (or even B, 7, II, or 12 amino acids), or fragments as processed and presented by MHC class II molecules, preferably having a length of about 13 or more amino acids, e.g.13, 14, 15, IB, 17, 18, 19, 2D or even more amino acids, wherein these fragments may be selected from any part of 5 the amino acid sequence. These fragments are typically recognized by T-cells in form of a complex consisting of the peptide fragment and an MHC molecule, i.e. the fragments are typically not recognized in their native form. Fragments of proteins or peptides may comprise at least one epitape of those proteins or peptides. Furthermore also domains of a protein, like the extracellular domain, the intracellular domain or the transmembrane domain and shortened or truncated versions of a protein may be understood to comprise a fragment of a protein.

0

As used herein, a "variant" of a protein or a peptide may be generated, having an amino acid sequence, which differs from the original sequence in one or more mutation(s), such as one or more substituted, inserted and/or deleted amino acid(s). Preferably, these fragments and/or variants have the same biological function or specific activity compared to the full-length native protein, e.g. its specific antigenic property. "Variants" of proteins or peptides as defined in the context of the present5 invention may comprise conservative amino acid substitution(s) compared to their native, i.e. non-mutated physiological, sequence. Those amino acid sequences as well as their encoding nucleotide sequences in particular fall under the term variants as defined herein. Substitutions in which amino acids, which originate from the same class, are exchanged for one another are called conservative substitutions. In particular, these are amino acids having aliphatic side chains, positively or negatively charged side chains, aromatic groups in the side chains or amino acids, the side chains of which can enter into hydrogen bridges,D e.g. side chains which have a hydroxyl function. This means that e.g. an amino acid having a polar side chain is replaced by another amino acid having a likewise polar side chain, or, for example, an amino acid characterized by a hydrophobic side chain is substituted by another amino acid having a likewise hydrophobic side chain (e.g. serine (threonine) by threonine (serine) or leucine (isoleucine) by isnleucine (leucine)). Insertions and substitutions are possible, in particular, at those sequence positions which cause no modification to the three-dimensional structure or do not affect the binding region. Modifications to a three-5 dimensional structure by insertion(s) or deletion(s) can easily be determined e.g. using CD spectra (circular dichroism spectra) (Urry, 1985, Absorption, Circular Dichroism and D D of Polypeptides, in: Modern Physical Methods in Biochemistry, Neuberger et al. (ed.), Elsevier, Amsterdam).

In the context of the present invention, a "variant" of a protein or peptide may have at least 50%, 51%, 52%, 53%, 54%, 55%,D 5B%, 57%, 58%, 59%, B0%, 61%. B2%, 63%, 64%. 65%. 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%.

78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 60%. 91%. 92%. 93%, 94%, 95%, 96%, 97%, 98%, or 99% amino acid identity over a stretch of at least ID, at least 20, at least 30, at least 5D, at least 75 or at least 100 amino acids of such protein or peptide. More preferably, a "variant" of a protein or peptide as used herein is at least 40%, preferably at least 50%, more preferably at least 60%, more preferably at least 70%, even more preferably at least 80%, even more preferably5 at least 90%. most preferably at least 95% identical to the protein or peptide, from which the variant is derived. Alternatively or additionally, a protein of the invention, a capsid protein, a Norovirus capsid protein VPI or a Norovirus capsid protein VP2 as defined herein refers to any polypeptide being identical or having in increasing order of preference at least 50%, 51%, 52%, 53%, 54%, 55%, 56%. 57%, 58%, 59%, BD%, Gl%, 62%. 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%. 74%, 75%, 76%, 77%, 78%, 79%, 80%. 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%. 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or more amino acid sequence identity to the protein of the invention, a capsid proteio, a Norovirus capsid protein VPI or a Norovirus capsid protein VP2 as represented by SEQ ID NOs: 1-4410, or to any of the full length polypeptide sequences given in SE010 NOs: 1-4410.

Furthermore, variants of proteins or peptides as defined herein, which may be encoded by a nucleic acid, may also comprise those sequences, wherein nucleotides of the encoding nucleic acid sequence are exchanged according to the degeneration of the genetic code, without leading to an alteration of the respective amino acid sequence of the protein or peptide, i.e. the amino acid sequence or at least part thereof may not differ from the original sequence in one or more mutatioo(s) within the above meaning.

According to a preferred embodiment, the at least one coding region of the inventive artificial nucleic acid comprises or consists of at least one nucleic acid sequence according to any one of SE0 ID NOs: 4411-39690, 39713-39746, or a fragment or variant of any of these sequences.

As used herein, a "fragment" of a nucleic acid sequence comprises or consists of a continuous stretch of nucleotides corresponding to a continuous stretch of nucleotides in the full-length nucleic acid sequence which is the basis for the nucleic acid sequence of the fragment, which represents at least 20%. preferably at least 30%. more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, even more preferably at least 80%, and most preferably at least 90% of the full-length nucleic acid sequence. Such a fragment, in the sense of the present invention, is preferably a functional fragment of the full-length nucleic acid sequence. In the context of the present invention, the phrase "variant of a nucleic acid sequence" typically relates to a variant of a nucleic acid sequence, which forms the basis of a nucleic acid sequence. For example, a variant nucleic acid sequence may exhibit one or more nucleotide deletions, insertions, additions and/or substitutions compared to the nucleic acid sequence, from which the variant is derived. Preferably, a variant of a nucleic acid sequence is at least 40%, preferably at least 50%. more preferably at least 60%, more preferably at least 70%, even more preferably at least 80%, even more preferably at least 90%, most preferably at least 95% identical to the nucleic acid sequence the variant is derived from. Preferably, the variant is a functional variant. A "variant" of a nucleic acid sequence may have at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%. 66%, 67%, 68%. 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% nucleotide identity over a stretch of at least 10, at least 20, at least 30, at least 50, at least 75 or at least 100 nucleotides of such nucleic acid sequence. Alternatively or additionally, a nuclBic acid sequence encoding a protein of the invention, a capsid protein, a Norovirus capsid protein VPI or a Norovirus capsid protein VP2 as defined herein refers to any nucleic acid sequence having in increasing order of preference at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%. 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%. 94%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to the nucleic acid sequence as represented by SEQ ID NOs: 4411-39690, 39713-39746, or to any of the full length polypeptide sequences given in SEQ. ID NOs: I- 4410.

Preferably, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of Norovirus capsid protein VPI, or a fragment or variant thereof. More preferably, the at least one encoded polypeptide comprises or consists of an amino acid sequence according to any one of SED ID NOs: 1-4410, or a fragment or variant of any of these sequences.

Alternatively or additionally, a nucleic acid sequence encoding a Norovirus capsid protein VPI as defined herein refers to any nucleic acid sequence being identical or having in increasing order of preference at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%. 59%, 60%, 61%, 62%, 63%, 64%, 65%. 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%.74%.75%, 76%, 77%, 78%, 79%, 80%. 81%. 82%. 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% or more sequence identity to the full-length nucleic acid sequence as represented by SED ID NOs: 4411-39690, 39713-39746. In certain embodiments, the at least one encoded polypeptide comprises or consists of a fragment of Norovirus capsid protein VPI or a variant of such a fragment. Preferably, the at least one encoded polypeptide comprises or consists of a C-terminal fragment of Norovirus capsid protein VPI, or a variant of such a fragment. In another embodiment, the at least one encoded polypeptide comprises Dr consists of an N-terminal fragment of Norovirus capsid protein VPI, or a variant of such a fragment. Preferably, the at least one encoded polypeptide comprises or consists of a fragment, preferably a C-terminal fragment, or a variant of such a fragment, of a Norovirus capsid protein VPI as present in a Norovirus polyprotein (precursor protein) before cleavage. In the context of the present invention, the phrase "Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage" typically refers to a continuous amino acid sequence beginning at the N-terminus of a Norovirus polyprotein (before cleavage) and comprising the amino acid residue immediately N-terminal of the first amino acid residue of a precursor of Norovirus pr protein as present in the Norovirus polyprotein. In other words, the phrase "Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage" may refer to a part of a Norovirus polyprotein corresponding to Norovirus capsid protein VPI comprising a C-terminal fragment, preferably a C-terminal signal sequence, which is typically not present in mature Norovirus protein VPI. For example, a 'Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage' as used herein may comprise an amino acid sequence derived from an amino acid sequence corresponding to amino acid residues I to 122 of a Norovirus polyprotein before cleavage. According to a preferred embodiment, a Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage comprises an amino acid sequence according to any one of SEQ ID NDs: I- 4410, or a fragment or variant of any of these sequences.

Hence, a "C-terminal fragment, or a variant of such a fragment, of Norovirus capsid protein VPI as present in a Norovirus 5 pnlyprotein (precursor protein) before cleavage" preferably comprises an amino acid sequence corresponding to a continuous amino acid sequence, which is located immediately N-terminal of Norovirus pr protein in a Norovirus polyprotein before cleavage, or to a fragment or variant of said amino acid sequence. Preferably, the C-terminal fragment, or a variant of such a fragment, of Norovirus capsid protein VPI as present in a Nnrovirus polyprotein (precursor protein) before cleavage comprises or consists of at least 3, 4, 5, G, 7, 8, 9, or, most preferably, at least ID amino acid residues. Alternatively, the C-terminal fragment, nr a ID variant of such a fragment, of Norovirus capsid protein VPI as present in a Norovirus polyprotein (precursor protein) before cleavage may consist of 3 to 4D, 3 to 3D, 3 to 2D, 5 to 2D or ID to 2D amino acid residues.

According to a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of at least one amino acid sequence derived from a signal sequence, or a fragment 15 Dr variant thereof.

As used herein, the term "signal sequence" preferably refers to an amino acid sequence, which is involved in the targeting of a protein, e.g. a Norovirus protein, to a cellular compartment, preferably a membrane, more preferably a membrane of the endoplasmic reticulum (E ). A signal sequence in the context of the present invention preferably comprises from 3 to 4D, 3 to 0 3D, 3 to 2D, 5 to 20 or 10 to 2D amino acid residues. Such a signal sequence may be present, for example, in a Norovirus polyprotein and may be removed during processing of said polyprotein. A signal sequence is preferably no longer present in a mature Norovirus protein. For example, Norovirus capsid protein VPI as present in a Norovirus polyprotein typically comprises a C-terminal signal sequence, corresponding to the amino acid sequence immediately N-terminal of Norovirus pr protein (e.g. amino acid residues ID5 to 122 in a Nnrovirus polyprotein before cleavage). That signal sequence is involved in targeting Norovirus 5 capsid protein VPI to the ER membrane and is typically removed in order to yield mature Norovirus capsid protein VPI, which no longer comprises said C-terminal fragment comprising a signal sequence.

Preferably, the amino acid sequence derived from a signal sequence, or a fragment or variant thereof, comprises at least 3, 4, 5, 6, 7, 8, 3, ID, II, 12, 13, 14, 15, IB, 17, 18, 19 or at least 2D amino acid residues. Alternatively, the amino acid sequence derived from D a signal sequence, or a fragment or variant thereof may consist of 3 to 4D, 3 to 30, 3 to 2D, 5 to 20 or ID to 2D amino acid residues. Most preferably, the amino acid sequence derived from a signal sequence, or a fragment or variant thereof consists of from 3 to 2D amino acid residues.

In a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial 35 nucleic acid comprises or consists of at least one amino acid sequence derived from a signal sequence, which comprises or consists of an amino acid sequence that is bound by signal recognition particle (SRP). More preferably, the at least one amino acid sequence derived from a signal sequence comprises or consists of an amino acid sequence that is recognized by signal peptide peptidase (SPP), by a viral protease and/or by furin or a furin-like protease. Most preferably, the at least one amino acid sequence derived from a signal sequence comprises an amino acid sequence that is recognized by a viral protease comprising one or more of a Norovirus non-structural protein selected from the group consisting of NSI/NS2, NS3, NS4, NS5, NSB. and NS7.

5

In a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of at least one amino acid sequence derived from a signal sequence of a secretory protein or from a signal sequence of a membrane protein. More preferably, the at least one amino acid sequence derived from a signal sequence, preferably derived from a signal sequence of a membrane protein, targets the at least one encoded protein to a ID cellular compartment, preferably to the endoplasmic reticulum (E ), more preferably to the ER membrane.

It is further preferred that the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of an amino acid sequence corresponding tc a signal sequence from a Norovirus protein, preferably from Norovirus capsid protein VPI, more preferably from Norovirus capsid protein VPI as present in a Norovirus polyprotein 15 before cleavage, or a fragment or variant of any of these.

According to a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of an amino acid sequence corresponding to a signal sequence from Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage, or a fragment or variant thereof, wherein the signalD sequence is preferably derived from a C-terminal fragment of Norovirus capsid protein VPI as present in a Norovirus polyprotein before cleavage, preferably as described herein.

According to another preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of a fragment, preferably a C-terminal fragment, or a variant of such a5 fragment, of a mature Norovirus protein, preferably of a mature Norovirus capsid protein VPI. In this context, it is preferred that the mature Norovirus protein is a mature Norovirus protein as defined herein.

According to a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of a fragment, preferably a C-terminal fragment, or a variant of such a fragment, ofD mature Norovirus capsid protein VPI, wherein the mature Norovirus capsid protein VPI does preferably not comprise a C-terminal signal sequence as described herein with respect to a Norovirus capsid protein VPI as present in a Norovirus polyprotein (before cleavage). More preferably, the mature Norovirus capsid protein VPI comprises or consists of an amino acid sequence according to any one of SEQ ID NOs: 1-4410, or a fragment or variant thereof. Preferably, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of a C-terminal fragment, preferably as defined herein, or a variant of such a fragment, of mature Norovirus capsid protein VPI.

5 Preferably, the C-terminal fragment, or a variant of such a fragment, of mature Norovirus capsid protein VPI comprises or consists of at least 3, , 5, 6, 7. 8, 9, or, most preferably, at least ID amino acid residues. Alternatively, the C-terminal fragment, or a variant of such a fragment, of mature Norovirus capsid protein VPI may comprise or consist of 3 to 40, 3 to 3D, 3 to 2D, 3 to ID, 5 to 20 or 10 to 20 amino acid residues. 0 According to another embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of an amino acid sequence derived from a

a) a C-terminal fragment, or a variant of such a fragment, of a mature Norovirus capsid protein VPI, preferably as defined herein

and

5 b) a C-terminal fragment, or a variant of such a fragment, of Norovirus capsid protein VPI as present in a Norovirus polyprotein (precursor protein) before cleavage, preferably as defined herein; or

a signal sequence, or a fragment or variant thereof, preferably as defined herein.

Therein, the amino acid sequence according to a) may be in continuation with the amino acid sequence according to b), whereinD the sequences may be positioned relative to each other in any manner. Alternatively, the amino acid sequences according to a) and b) may be separated in the at least one encoded protein by another amino acid sequence. Most preferably, the amino acid sequence according to a) is located N-terminally with respect to b).

According to a preferred embodiment, the at least Dne polypeptide encoded by the at least one coding region of the inventive5 artificial nucleic acid comprises or consists of at least one amino acid sequence corresponding to a fragment of Norovirus nonstructural protein I (NSI/2), or a variant of such a fragment.

As used herein, the term "fragment of Norovirus non-structural protein I (NSI/2)" preferably relates to a continuous amino acid sequence derived from Norovirus non-structural protein I (NSI/2), or to a fragment or variant of said continuous amino acidD sequence.

Preferably, the fragment, or variant thereof, of Norovirus non-structural protein I (NSI/2) comprises or consists of at least 3, 4, 5, G, 7, 8, 9, or, most preferably, at least 10 amino acid residues. Alternatively, the fragment, or variant thereof, of Norovirus non-structural protein I (NSI/2) may comprise or consist of 3 to 40, 3 to 30. 3 to 20, 3 to 10, 5 to 2D or 10 to 2D amioo acid5 residues. Most preferably, the fragment, or variant thereof, of Norovirus non-structural protein I (NSI/2) comprises or consists of from 3 to 20 amino acid residues. In a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of at least one amino acid sequence corresponding to an N-terminal fragment of Norovirus non-structural protein I (NSI/2). or a variant of said fragment.

5

In the context of the present invention, the term "N-terminal fragment of Norovirus non-structural protein I (NSI/2)" relates to a continuous amino acid sequence derived from the N-tBrminus of Norovirus non-structural protein I (NSI/2). More preferably, the N-terminal fragment of Norovirus non-structural protein I (NSI/2) comprises or consists of from 3 to 2D amino acid residues. In a preferred embodiment, the at least one encoded polypeptide comprises an N-terminal fragment of Norovirus non-structural I0 protein I (NSI/2), wherein the N-terminal fragment of Norovirus non-structural protein I (NSI/2) is a continuous amino acid sequence comprising or consisting of 3 to 2D amino acid residues corresponding to a continuous amino acid sequence of 3 to 2D amino acid residues in the first 2D amino acid residues (counting from the N-terminus) of Norovirus non-structural protein I (NSI/2), or a variant thereof.

I5 In one embodiment, the at least one encoded polypeptide comprises or consists of an N-terminal fragment of Norovirus non ^¬ structural protein I (NSI/2), wherein the N-terminal fragment of Norovirus non-structural protein I (NSI/2) is a continuous amino acid sequence comprising or consisting of 3 to 20 amino acid residues corresponding to a continuous amino acid sequence of 3 to 2D amino acid residues in the first 2D amino acid residues (counting from the N-terminus) of a mature Norovirus non ^¬ structural protein I (NSI/2), or a variant thereof. Therein, the first 2D amino acid residoes of a mature Norovirus non-structuralD protein I (NSI/2) preferably comprise or consist of the N-terminus itself (i.e. the amino acid residue at the N-terminus) and the I9 following amino acid residues.

In a preferred embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises a first Norovirus protein, which is preferably a Norovirus protein as described herein, or a fragment or5 variant thereof, and further comprises at least one second or further Norovirus protein, or a fragment or variant thereof, wherein the at least one second or further Norovirus protein, or the fragment or variant thereof, is distinct from the first Norovirus protein, or the fragment or variant thereof.

In that embodiment, the first Norovirus protein is preferably selected from the groop consisting of Norovirus NSI/NS2, NS32A,0 NS42B, NS53, NSG4A, NS4B or NS75, or a fragment or variant thereof. Preferably, the second or further Norovirus protein is selected from the group consisting of Norovirus capsid protein VPI, Norovirus capsid protein VP2 and a Norovirus non-structural protein, preferably Norovirus NSI/NS2, NS3, NS4, NS5, NSB, or NS7, or a fragment or variant thereof.

More preferably, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid5 comprises Norovirus capsid protein VPI and/or VP2, or a fragment or variant thereof, and further comprises at least one of the following: a) an amino acid sequEncE corrEsponding to a C-terminal fragment, or a variant thereof, of mature Norovirus capsid protein VPI, preferably as described herein;

b) an amino acid sequence corresponding to a C-terminal fragment, or a variant thereof, of Norovirus capsid protein VPI as present in Norovirus polyprotein before cleavage, preferably as described herein;

c) an amino acid sequence corresponding to an N-terminal fragment, or a variant thereof, of Norovirus non-structural protein I (NSI/NS2), preferably as described herein; and/or

d) an amino acid corresponding to a fragment of Norovirus NSI/NS2, NS3, NS4, NS5, NSB, or NS7.

In a further embodiment, the at least one polypeptide encoded by the at least one coding region of the inventive artificial nucleic acid comprises or consists of, preferably in this order from N-terminus to C-terminus, Norovirus capsid protein VPI, or a fragment or variant thereof,

and Norovirus non-structural protein I (NSI/NS2), or a fragment or variant thereof.

According to a preferred embodiment, the inventive artificial nucleic acid is monocistronic, bicistronic or multicistronic.

Preferably, the inventive artificial nucleic acid is monocistronic. In that embodiment, the inventive artificial nucleic acid comprises one coding region, wherein the coding region encodes a polypeptide comprising at least two different Norovirus proteins, preferably as defined herein, or a fragment or variant thereof.

Alternatively, the inventive artificial nucleic acid can be bi- or multicistronic and comprises at least two coding regions, wherein the at least two coding regions encode at least two polypeptides, wherein each of the at least two polypeptides comprises at least one different Norovirus protein, preferably as described herein, or a fragment or variant of any one of these proteins. For example, the inventive artificial nucleic acid may comprise two coding regions, wherein the first ending region encodes a first polypeptide comprising a first Norovirus protein, or a fragment or variant thereof, and wherein the second coding region encodes a second polypeptide comprising a second Norovirus protein, or a fragment or variant thereof, wherein the first and second Nnrovirus proteins or a fragment or variant thereof are distinct from each other.

The inventive artificial nucleic acid may be provided as DNA or as NA, preferably an RNA as defined herein. More preferably, the inventive artificial nucleic acid is an artificial mRNA.

The inventive artificial nucleic acid may further be single stranded or double stranded. When provided as a double stranded nucleic acid, the inventive artificial nucleic acid preferably comprises a sense and a corresponding antisense strand.

Preferably, the inventive artificial nucleic acid as defined herein typically comprises a length of about 50 to about 20000, or 100 to about 20000 nucleotides, preferably of about 25D to about 20000 nucleotides, more preferably of about 500 to about 10000, even more preferably of about 500 to about 5000. Nucleic acid modifications:

According to one embodiment, the inventive artificial nucleic acid as defined herein, may be in the form of a modified nucleic acid, preferably a modified mRNA, wherein any modification, as defined herein, may be introduced into the inventive artificial nucleic 5 acid. Modifications as defined herein preferably lead to a stabilized artificial nucleic acid, preferably a stabilized artificial RNA, of the present invention.

According to one embodiment, the inventive artificial nucleic acid, preferably an mRNA, may thus be provided as a "stabilized nucleic acid", preferably as a "stabilized mRNA", that is to say as a nucleic acid, preferably an mRNA, that is essentially resistant

ID to in vivo degradation (e.g. by an exo- or endo-nuclease). Such stabilization can be effected, for example, by a modified phosphate backbone of an artificial mRNA of the present invention. A backbone modification in connection with the present invention is a modification in which phosphates of the backbone of the nucleotides contained in the mRNA are chemically modified. Nucleotides that may be preferably used in this connection contain e.g. a phosphorothioate-modified phosphate backbone, preferably at least one of the phosphate oxygens contained in the phosphate backbone being replaced by a sulfur atom. Stabilized artificial nucleic

15 acids, preferably mRNAs, may further include, for example: non-ionic phosphate analogues, such as, for example, alkyl and aryl phosphonates, in which the charged phosphonate oxygen is replaced by an alkyl or aryl group, or phosphodiesters and alkylphosphotriesters, in which the charged oxygen residue is present in alkylated form. Such backbone modifications typically include, without implying any limitation, modifications from the group consisting of methylphosphonates, phosphoramidates and phosphorothioates (e.g. cytidine-5'-0-(l-thiophosphate)).

D

In the following, specific modifications are described, which are preferably capable of "stabilizing" the inventive artificial nucleic acid, preferably an mRNA, as defined herein.

Chemical modifications:

5 The terms "nucleic acid modification" as used herein may refer to chemical modifications comprising backbone modifications as well as sugar modifications or base modifications.

In this context, a modified artificial nucleic acid, preferably an mRNA, as defined herein may contain nucleotide analogues/modifications, e.g. backbone modifications, sugar modifications or base modifications. A backbone modification in connection with the present invention is a modification, in which phosphates of the backbone of the nucleotides contained in anD artificial nucleic acid, preferably an mRNA, as defined herein are chemically modified. A sugar modification in connection with the present invention is a chemical modification of the sugar of the nucleotides of the artificial nucleic acid, preferably an mRNA, as defined herein. Furthermore, a base modification in connection with the present invention is a chemical modification of the base moiety of the nucleotides of the artificial nucleic acid, preferably an mRNA. In this context, nucleotide analogues or modifications are preferably selected from nucleotide analogues, which are applicable for transcription and/ or translation. 5 Sugar Modifications:

The modified nucleosides and nucleotides, which may be incorporated into a modified artificial nucleic acid, preferably an m NA, as described herein, can be modified in the sugar moiety. For example, the 2' hydroxyl group (OH) can be modified or replaced with a number of different "oxy" or "deoxy" substituents. Examples of "oxy" -2' hydroxy! group modifications include, but are not 5 limited to, alkoxy or aryloxy (-DR. e.g., R = H, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or sugar); polyethyleneglycols (PEG), - D(CH2CHzQ)nCH2CH2DR; "locked" nucleic acids (LNA) in which the 2' hydroxyl is connected, e.g., by a methylene bridge, to the 4' carbon of the same ribose sugar; and amino groups (-D-amino, wherein the amino group, e.g., HRR, can be alkylamino, dialkylamino, heteracyclyl. arylamino, diarylaminn, heteroarylamino, or diheteroaryl amino, ethylene diamine, polyamino) or aminoalkoxy.

ID "Deoxy" modifications include hydrogen, amino (e.g. NH2; alkylamino, dialkylamino, heteracyclyl, arylamino, diaryl amino, heteroaryl amino, diheteroaryl amino, or amino acid); or the amino group can be attached to the sugar through a linker, wherein the linker comprises one or more of the atoms C, N, and D.

The sugar group can also contain one or more carbons that possess the opposite stereochemical configuration than that of the corresponding carbon in ribose. Thus, an artificial nucleic acid, preferably an mRNA, can include nucleotides containing, for 15 instance, arabinose as the sugar.

Backbone Modifications:

The phosphate backbone may further be modified in the modified nucleosides and nucleotides, which may be incorporated into a modified artificial nucleic acid, preferably an mRNA, as described herein. The phosphate groups of the backbone can be modifiedD by replacing one or more of the oxygen atoms with a different substituent. Further, the modified nucleosides and nucleotides can include the full replacement of an unmodified phosphate moiety with a modified phosphate as described herein. Examples of modified phosphate groups include, but are not limited to, phosphorothioate, phosphoroselenates, borano phosphates, borano phosphate esters, hydrogen phosphonates, phosphoroamidates, alkyl or aryl phosphonates and phasphotriesters. Phosphorodithiaates have both non-linking oxygens replaced by sulfur. The phosphate linker can also be modified by the5 replacement of a linking oxygen with nitrogen (bridged phosphoroamidates), sulfur (bridged phosphorDthioates) and carbon (bridged methylene-phosphonates).

Base Modifications:

The modified nucleosides and nucleotides, which may be incorporated into a modified nucleic acid, preferably an mRNA, asD described herein can further be modified in the nucleobase moiety. Examples of nuclenbases found in a nucleic acid such as RNA include, but are not limited to. adenine, guanine, cytosine and uracil. For example, the nucleosides and nucleotides described herein can be chemically modified on the major groove face. In some embodiments, the major groove chemical modifications can include an amino group, a thiol group, an alkyl group, or a halo group. 5 In particularly preferred embodiments of the present invention, the nucleotide analogues/ modifications are selected from base modifications, which are preferably selected from 2-amino-B-chloropurineriboside-5'-triphosphate, 2-Aminopurine-riboside-5'- triphasphate; 2-aminaadenosine-5'-triphosphatE, 2'-Amino-2'-deoxycytidine-triphDsphatB, 2-thiocytidinB-5'-triphosphate. 2- thiouridinB-5'-triphosphatE, 2'-FluarathymidinB-5'-triphosphate, 2'-D-Methyl inDsine-5'-triphosphate 4-thiouridine-5'- triphosphate, 5-aminoallylcytidine-5'-triphasphatB, 5-aminoallyluridine-5'-triphosphatB, 5-brDmacytidinB-5'-triphDsphatE, 5- bromouridine-5'-triphosphate, 5-Bromo-2'-deoxycytidine-5'-triphosphate, 5-BromQ-2'-dEDxyuridine-5'-triphosphate, 5- iodocytidinE-5'-triphasphatE, 5-lado-2'-dEoxycytidinE-5'-triphosphatB. 5-iodouridinE-5'-triphosphatB. 5-lodo-2'-dBoxyuridine- 5'-triphosphate, 5-mBthylcytidinE-5'-triphDsphatE, 5-mBthyluridinE-5'-triphosphate, 5-PropynyI-2'-dBOxycytidine-5'- triphosphate, 5-Prapynyl-2'-dEDxyuridinE-5'-triphDsphatE, B-azacytidine-S'-triphosphate, B-azauridine-5'-triphosphatB, 6- chlDrapurinEribDside-5'-triphosphatB, 7-deazaadenDsine-5'-triphDsp ate, 7-dBazaguanasinB-5'-triphosphatB, 8-azaadenasine- 5'-triphosphatB. 8-azidoadBnosinB-5'-triphosphate, benzimtdazalB-ribosidE-5'-triphasphate, NI-mEthyladenosine-5'- triphosphate. NI-mBthylguanasinE-5'-triphasphatE, N6-mBthyladEnosinB-5'-triphosphate, 06-mBthylguanosinE-5'-triphosphatB, pseudouridinB-5'-triphosphatB, or puromycin-5'-triphosphatE, xanthosine-S'-triphosphatB. Particular prBfereocE is given to nuclBotidEs for bass modifications sElsctEd from the group of basB-modifiEd nuclBotidEs consisting of 5-methylcytidine-5'- triphosphatB, 7-dEazaguanosinB-5'-triphosphatB, 5-bromocytidine-5'-triphosphate. and pseudouridine-5'-triphosphatE.

In somE Embodiments, modified nuclBosides includE pyridin-4-nnB ribonuclBosidE. 5-aza-uridine, 2-thio-5-aza-uridine, 2- thiouridine, 4-thio-pseudouridine, 2-thio-psBudouridinB, 5-hydroxyuridinB, 3-mBthyluridine, 5-carboxymBthyl-uridine, I- carboxymethyl-psEudouridinB, 5-propynyl-uridine, 1-propynyl-psEudouridinE, 5-taurinomethyluridinB. l-taurinomethyl- psEudouridinB, 5-taurinomBthyl-2-thio-uridinB, l-taurinomBthyl-4-thio-uridinE, 5-mEthyl-uridinE, l-mEthyl-psBudouridine, 4-thio- 1-methyl-psBudauridinB, 2-thio-l-methyl-pseudouridine, 1-methyl-l-dEaza-psEudouridinB, 2-thio-l-mBthyl-l-dEaz8-psEudouridinB, dihydrouridine, dihydropsEudouridinB, 2-thio-dihydrouridinE, 2-thio-dihydropsBudouridinB, 2-mEthoxyuridinB, 2-mEthoxy-4-thio- uridine, 4-methoxy-psBudouridine, and 4-methDxy-2-thio-psEudouridine.

In some embodiments, modified nucleosidBs includE 5-aza-cytidinB, pseudoisocytidinE, 3-mBthyl-cytidinB, N4-acetylcytidinE, 5- formylcytidinE, N4-methylcytidine, 5-hydroxymethylcytidinE, 1-mEthyl-psEudoisocytidinE, pyrrolo-cytidinE, pyrrolo- psBudoisocytidinE, 2-thio-cytidinE, 2-thio-5-mEthyl-cytidine, 4-thio-pseudoisocytidine, 4-thio-l-mBthyl-pseudoisocytidine, 4-thio- l-mEthyl-l-deaza-psBudoisocytidinE, 1-methyl-l-dEaza-psBudoisocytidinE, ZEbularins, 5-aza-zEbularine, 5-methyl-ZBbularinB, 5- aza-2-thio-zEbularine, 2-thio-zebularinB, 2-mEthoxy-cytidinB, 2-mBthoxy-5-methyl-cytidine, 4-methoxy-pseudoisocytidinE, and 4-mEthoxy-l-mEthyl-psEudoisocytidine. In Dther embodiments, modified nuclBosidBS include 2-aminopurine, 2, B-diaminopurinB,

7- deaza-adEnine, 7-dBaza-8-aza-adBninB, 7-dEaza-2-aminopurinE, 7-dEaza-8-aza-2-aminopurinB, 7-deaza-2,B-diaminopurinB, 7- dBaza-8-aza-2,6-diaminopurinE, 1-methyladEnosine, NB-mBthyladEnosinE, NB-isopentenyladenasine, N6-(cis- hydroxyisopentenylJadEnosine, 2-mEthylthio-NB-(cis-hydroxyisopBntBnyl) adenosine, NB-glycinylcarbamoyladenosine, NB- threonylcarbamoyladenosine, 2-mBthylthio-NB-threonyl carbamoyladenosine, NG.NB-dimBthyladenosinB, 7-methyladenine. 2- mEthylthio-adeninB. and 2-mBthoxy-adEnine.

In other embodiments, modified nucleosides include inosine, 1-mBthyl-inosinE, wyosinE, wybutnsine, 7-dsaza-guanosinE, 7-deaza-

8- aza-guanosine, B-thio-guanosine, B-thio-7-deaza-guanosine, B-thio-7-deaza-8-aza-guanosine, 7-methyl-guanosine, B-thio-7- mEthyl-guanosinB, 7-methyfinosinB, B-methoxy-guanosine, f-methylguanasine, N2-methylguanosinB. N2,N2-dimEthylguanosinE, 8- oxo-guanosino, 7-methyl-8-oxo-guanosinE, l-mEthyl-B-thio-guanosinE, N2-mBthyl-B-thio-guanosinB, and N2,N2-dimethyl-6-thio- guanosine. In some Embodiments, the nucleotide can be modified on the major groove face and can include replacing hydrogen on C-5 of uracil with a methyl group or a halo group. In specific embodiments, a modified nucleoside is 5'-D-(l-thiophusphatE)-adenosine, 5'-0-(l-thiophosphate)-cytidine, 5'-0-(l-thiophosphate)-guanosine, 5'-0-(l-thiophosphate)-uridine or 5'-0-(l-thiophosphate)- pseudouridine.

5 In further specific embodiments, a modified artificial nucleic acid, preferably an mRNA, may comprise nucleoside modifications selected from 6-aza-cytidine, 2-thiD-cytidine, a-thio-cytidine, Pseudo-isu-cytidine, 5-aminoaHyl-uridine, 5-iodo-uridinB, Nl- methyl-pseudouridine, 5,6-dihydrouridine, a-thio-uridine, 4-thio-uridine, B-aza-uridine, 5-hydroxy-uridine, deoxy-thymidine, 5- methyl-uridine, Pyrrolo-cytidine, inosine, a-thio-guanasine, B-methyl-guanosine, 5-methyl-cytdine, 8-oxo-guanosinE, 7-deaza- guanosine, Nl-methyl-adenosine, 2-amino-B-Chloro-purine, NB-methyl-2-amino-purine, Pseudo-iso-cytidine, 6-Chloro-purine,

ID NB-methyl-adenosine, α-thio-adenosine, 8-azido-adenosine, 7-deaza-adenosine.

Lipid modification:

According to a further embodiment, a modified artificial nucleic acid, preferably an mRNA, as defined herein can contain a lipid modification. Such a lipid-modified artificial nucleic acid as defined herein typically further comprises at least one linker

15 covalently linked with that artificial nucleic acid, and at least one lipid covalently linked with the respective linker. Alternatively, the lipid-modified artificial nucleic acid comprises at least one artificial nucleic acid as defined herein and at least one (Afunctional) lipid covalently linked (without a linker) with that artificial nucleic acid. According to a third alternative, the lipid- modified artificial nucleic acid comprises an artificial nucleic acid molecule as defined herein, at least Dne linker covalently linked with that artificial nucleic acid, and at least one lipid covalently linked with the respective linker, and also at least oneD (Afunctional) lipid covalently linked (without a linker) with that artificial nucleic acid. In this context, it is particularly preferred that the lipid modification is present at the terminal ends of a linear artificial nucleic acid.

Coding sequence modifications:

G/C content modification:

5 According to another embodiment, the artificial nucleic acid of the present invention may be modified, and thus stabilized, by modifying the G/C content of the artificial nucleic acid, preferably an mRNA, preferably of the coding region of the inventive artificial nucleic acid.

Preferably, the G/C content of the at least one coding region of the artificial nucleic acid, preferably an mRNA, is modified,D preferably increased, compared to the G/C content of the corresponding coding sequence of the wild type nucleic acid, preferably an mRNA, wherein the encoded amino acid sequence is preferably not modified compared to the amino acid sequence encoded by the corresponding wild type nucleic acid (i.e. the non-modified nucleic acid), preferably an mRNA. This modification of the inventive artificial nucleic acid, preferably of an mRNA, as described herein is based on the fact that the sequence of any mRNA region to be translated is important for efficient translation of that mRNA. Thus, the composition and the sequence of various 5 nucleotides are important. In particular, sequences having an increased G (guanosine)/C (cytosine) content are more stable than sequences having an increased A (adenosine)/U (uracil) content. According to the invention, the codons of the artificial nucleic acid, preferably an mRNA, are therefore varied compared to the respective wild type mRNA, while retaining the translated amino acid sequence, such that they include an increased amount of G/C nucleotides. In respect to the fact that several codons encode one and the same amino acid (so-called degeneration of the genetic code), the most favorable codons for the stability can be determined (so-called alternative codon usage). Depending on the amino acid to be encoded by the artificial nucleic acid, 5 preferably an mRNA, there are various possibilities for modification of its sequence, compared to its wild type sequence. In the case of amino acids which are encoded by codons, which contain exclusively G or C nucleotides, no modification of the codon is necessary. Thus, the codons for Pro (CCC or CCG), Arg (CGC or CGG), Ala (GCC or GCG) and Gly (GGC or GGG) require no modification, since no A or U is present. In contrast, codons which contain A and/or U nucleotides can be modified by substitution of other codons, which code for the same amino acids but contain no A and/or U. Examples of these are: the codons for Pro can

ID be modified from CCU or CCA to CCC or CCG; the codons for Arg can be modified from CGU or CGA or AGA or AGG to CGC or CGG; the codons for Ala can be modified from GCU or GCA to GCC or GCG; the codons for Gly can be modified from GGU or GGA to GGC or GGG. In other cases, although A or U nucleotides cannot be eliminated from the codons, it is however possible to decrease the A and U content by using codons, which contain a lower content of A and/ or U nucleotides. Examples of these are: the codons for Phe can be modified from UUU to UUC; the codons for Leu can be modified from UUA, UUG, CUU or CUA to CUC or CUG; the codons

15 for Ser can be modified from UCU or UCA or AGU to UCC, UCG or AGC; the codon for Tyr can be modified from UAU to UAC; the codon for Cys can be modified from UGU to UGC; the codon for His can be modified from CAU to CAC; the codon for Gin can be modified from CAA to CAG: the codons for He can be modified from AUU or AUA to AUG; the codons for Thr can be modified from ACU or ACA to ACC or ACG; the codon for Asn can be modified from AAU to AAC; the codon for Lys can be modified from AAA to AAG; the codons for Val can be modified from GUU or GUA to GUC or GUG; the codon for Asp can be modified from GAU to GAC;0 the codon for Glu can be modified from GAA to GAG; the stop codon UAA can be modified to UAG or UGA. In the case of the codons for Met (AUG) and Trp (UGG), on the other hand, there is no possibility of sequence modification. The substitutions listed above can be used either individually or in all possible combinations to increase the G/C content of the inventive artificial nucleic acid, preferably an mRNA, compared to its corresponding wild type sequence, such as the corresponding wild type mRNA sequence. Thus, for example, all codons for Thr occurring in the wild type sequence can be modified to ACC (or ACG). Preferably, however,5 for example, combinations of the above substitution possibilities are used:

substitution of all codons coding for Thr in the original sequence (wild type mRNA) to ACC (or ACG) and

substitution of all codons originally coding for Ser to UCC (or UCG or AGC); substitution of all codons coding for He in the original sequence to AUC and substitution of all codons originally codiog for Lys to AAG and substitution of all codons originally coding for Tyr to UAC; substitution of all codons coding for Val in the original sequence to GUC (or GUG) and substitution of all codonsD originally coding for Glu to GAG and substitution of all codons originally coding for Ala to GCC (or GCG) and substitution of all codons originally coding for Arg to CGC (or CGG); substitution of all codons coding for Val in the original sequence to GUC (or GUG) and substitution of all codons originally coding for Glu to GAG and substitution of all codons originally coding for Ala to GCC (or GCG) and substitution of all codons originally coding for Gly to GGC (or GGG) and substitution of all codons originally coding for Asn to AAC; substitution of all codons coding for Val in the original sequence to GUC (or GUG) and substitution of all codons5 originally coding for Phe to UUC and substitution of all codons originally coding for Cys to UGC and substitution of all codons originally coding for Leu to CUG (or CUC) and substitution of all codons originally coding for Gin to CAG and substitution of all codons originally coding for Pro to CCC (or CCG); etc. Preferably, the G/C content of the coding region of the inventive artificial nucleic acid, preferably an mRNA, is increased by at least 7%. more preferably by at least 15%, particularly preferably by at least 20%, compared to the G/C content of the coding region of the wild type nucleic acid. According to a specific embodiment at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, more preferably at least 70%, even more preferably at least 80% and most preferably at least 90%, 95% or even 100% of the substitutable codons in the coding region or the whole sequence of the wild type nucleic acid sequence, preferably an mRNA sequence, are substituted, thereby increasing the G/C content of said sequence. In this context, it is particularly preferable to increase the G/C content of the inventive artificial nucleic acid to the maximum (i.e.100% of the substitutable codons), in particular in the region coding for the at least one protein, compared to the wild type sequence.

In one embodiment of the invention, the G/C content of the artificial nucleic acid of the invention is increased compared to the G/C content of the corresponding coding sequence of the wild type mRNA, or wherein the C content of the coding region of the mRNA sequence is increased compared to the C content of the corresponding coding sequence of the wild type mRNA, or wherein the codon usage in the coding region of the mRNA sequence is adapted to the human codon usage, or wherein the codon adaptation index (CAI) is increased or maximised in the coding region of the mRNA sequence, wherein the encoded amino acid sequence of the mRNA sequence is preferably not being modified compared to the encoded amino acid sequence of the wild type mRNA.

In a further embodiment, the artificial nucleic acid according to the invention is codon optimized,

wherein

(i) the at least one coding region comprises a nucleic acid sequence, which is codon-optimized; and/ or

(ii) the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, BD%, 70%, 80%, 85%, 86%. 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEQ 10 NOs: 8821-13230, 26461-39690, 39715, 39716, 39717, 39720, 39721, 39724, 39725, 39728, 39729, 39730, 39733, 39734, 39737, 39738, 39741, 39742, 39745 and 39746, or a fragment or variant of any of these sequences; and/or

(iii) the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 13231-17640, or a fragment or variant of any of these sequences; and/or

(iv) the artificial nucleic acid of the invention, wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%. 60%, 7D%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 17641- 22050, or a fragment or variant of any of these sequences; and/ or

(v) the artificial nucleic acid of the invention, wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEQ ID NDs: 22051- 26460, or a fragment or variant of aoy of these sequences. According to the invention, a further preferred modification of the artificial nucleic acid of the present invention is based on the finding that the translation efficiency is also determined by a different frequency in the occurrence of tRNAs in cells. It is thus preferred that the at least one coding region of the artificial nucleic acid according to the invention comprises a nucleic acid 5 sequence, which is codon-optimized. The term "codon-optimized" as used herein typically refers to an artificial nucleic acid, preferably to a nucleic acid sequence in the at least one coding region therein, wherein at least one codon of the wild type sequence, which codes for a tRNA which is relatively rare in the cell, is exchanged for a codon, which codes for a tRNA which is relatively frequent in the cell and carries the same amino acid as the relatively rare tRNA. Most preferably, that modification also increases the G/C content of the at least one coding region of the artificial nucleic acid.

ID

Thus, if so-called "rare codons" are present in the artificial nucleic acid of the present invention to an increased extent, the corresponding modified nucleic acid sequence, preferably an mRNA sequence, is translated to a significantly poorer degree than in the case where codons coding for relatively "frequent" tRNAs are present. According to the invention, in the modified artificial nucleic acid of the present invention, the region which encodes the at least one protein as defined herein is modified compared 15 to the corresponding region of the wild type nucleic acid, preferably an mRNA, such that at least one codon of the wild type sequence, which codes for a tRNA which is relatively rare in the cell, is exchanged for a codon, which codes for a tRNA which is relatively frequent in the cell and carries the same amino acid as the relatively rare tRNA. By this modification, the sequences of the artificial nucleic acid of the present invention is modified such that codons for which frequently occurring tRNAs are available are inserted. In other words, according to the invention, by this modification all codons of the wild type sequence which code forD a tRNA which is relatively rare in the cell can in each case be exchanged for a codon which codes for a tRNA which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA. Which tRNAs occur relatively frequently in the cell and which, in contrast, occur relatively rarely is known to a person skilled in the art; cf. e.g. Akashi, Curr. Dpin. Genet. Dev. 2DDI, 11(G): GGD-GBG. The codons which use for the particular amino acid the tRNA which occurs the most frequently, e.g. the Gly codon, which uses the tRNA, which occurs the most frequently in the (human) cell, are particularly5 preferred. According to the invention, it is particularly preferable to link the sequential G/C content which is increased, in particular maximized, in the modified artificial nucleic acid of the present invention, with the "frequent" codons without modifying the amino acid sequence of the protein encoded by the coding region of the corresponding wild type nucleic acid, preferably an mRNA. This preferred embodiment allows provision of a particularly efficiently translated and stabilized (modified) artificial nucleic acid of the present invention. The determination of an artificial nucleic acid of the present invention as described above0 (increased G/C content; exchange of tRNAs) can be carried out using the computer program explained in WD D2/098443 - the disclosure content of which is included in its full scope in the present invention. Using this computer program, the nucleotide sequence of any desired mRNA can be modified with the aid of the genetic code or the degenerative nature thereof such that a maximum G/C content results, in combination with the use of codons which code for tRNAs occurring as frequently as possible in the ceil, the amino acid sequence encoded by the artificial nucleic acid preferably not being modified compared to the non- 5 modified sequence. Alternatively, it is also possible to modify only the G/C content or only the codon usage compared to the original sequence. The source code in Visual Basic G.D (developmeot environment used: Microsoft Visual Studio Enterprise G.O with Servieepack 3) is also described in WO 02/098443. In a further preferred embodiment of the present invention, the A/U content in the environment of the ribosome binding site of the artificial nucleic acid of the present invention is increased compared to the A/U content in the environment of the ribosome binding site of its particular wild type nucleic acid, preferably an m NA. This modification (an increased A/U content around the ribosome binding site) increases the efficiency of ribosome binding to the artificial nucleic acid. An effective binding of the ribosomes to the ribosome binding site (e.g. a Kozak sequence as known in the art) in turn has the effect of an efficient translation of the artificial nucleic acid. According to a further embodiment of the present invention, the artificial nucleic acid of the present invention may be modified with respect to potentially destabilizing sequence elements. Particularly, the coding region and/or the 5' and/or 3' untranslated region of the artificial nucleic acid may be modified compared to the particular wild type nucleic acid such that it contains no destabilizing sequence elements, the amino acid sequence encoded by the modified artificial nucleic acid preferably not being modified compared to its particular wild type nucleic acid. It is known that, for examplG, in sequences of eukaryotic NAs destabilizing sequence elements (DSE) occur, to which signal proteins bind and regulate enzymatic degradation of RNA in vivo. For further stabilization of the modified artificial nucleic acid, optionally in the region which encodes the at least one protein as defined herein, one or more such modifications compared to the corresponding region of the wild type nucleic acid, preferably an mRNA, can therefore be carried out, so that no or substantially no destabilizing sequence elements are contained there. According to the invention, OSE present in the untranslated regions (3'- and/or 5'-UTR) can also be eliminated from the artificial nucleic acid of the present invention by such modifications. Such destabilizing sequences are e.g. AU-rich sequences (AURES), which occur in 3'-UTR sections of numerous unstable RNAs (Caput et al„ Proc. Natl. Acad. Sci. USA I98B, 83: 1670 to IB74). The artificial nucleic acid of the present invention is therefore preferably modified compared to the wild type nucleic acid such that the artificial nucleic acid contains no such destabilizing sequences. This also applies to those sequence motifs which are recognized by possible endonucleases, e.g. the sequence GAACAAG, which is contained in the 3'-UTR segment of the gene which codes for the transferrin receptor (Binder et al., E BU J. 1394, 13: 19B9 to 1980). These sequence motifs are also preferably removed in the artificial nucleic acid of the present invention. It is further preferred that the artificial nucleic acid of the present invention has, in a modified form, at least one IRES as defined above and/or at least one 5' and/or 3' stabilizing sequence, in a modified form, e.g. to enhance ribosome binding or to allow expression of different encoded polypeptides located on an artificial nucleic acid of the present invention. This particularly applies to embodiments, wherein the artificial nucleic acid is bi- or multicistronic and wherein an IRES is preferably located between individual coding regions.

According to a preferred embodiment, the at least one coding region of the artificial nucleic acid or artificial nucleic acid molecule comprises or consists of at least one nucleic acid sequence according to any one of SEQ ID NOs: 8821-39690, 39715. 397IB, 39717, 39720, 39721, 39724. 39725, 39728, 39729, 39730, 39733, 39734, 39737, 39738, 39741, 39742, 30745 and 39746, or a fragment or variant of any of these sequences. More preferably, the at least one coding region of the artificial nucleic comprises or consists of an RNA sequence, which is at least 5D , 51%, 52%, 53%, 54%, 55%, 56%. 57%, 58%, 59%, 60%, 61%. 62%. 63%, 64%, 65%. 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 70%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%. or 99% identical to any one of SEQ ID NOs: 882I-39690, 3B7I5, 397I6, 397I7, 39720. 397ZI, 39724, 39725, 39728, 39729, 39730, 39733, 39734, 39737, 39738, 3974I, 39742, 39745 and 3974B.

G/C content modification:

5 According to another embodiment, the RNA of the present invention, preferably an mRNA, may be modified, and thus stabilized, by modifying the guanosine/ cytosine (G/C) content of the RNA, preferably of the at least one coding sequence of the RNA of the present invention.

In a particularly preferred embodiment of the present invention, the G/C content of the coding region of the RNA of the present

ID invention is modified, particularly increased, compared to the G/C content of the coding region of the respective wild type RNA, i.e. the unmodified RNA. The amino acid sequence encoded by the RNA is preferably not modified as compared to the amino acid sequence encoded by the respective wild type RNA. This modification of the RNA of the present invention is based on the fact that the sequence of any RNA region to be translated is important for efficient translation of that RNA. Thus, the composition of the RNA and the sequence of various nucleotides are important. In particular, sequences having an increased G (guanosine)/C

I5 (cytosine) content are more stable than sequences having an increased A (adenosine)/U (uracil) content. According to the invention, the codons of the RNA are therefore varied compared to the respective wild type RNA, while retaining the translated amino acid sequence, such that they include an increased amount of G/C nucleotides. In respect to the fact that several codons code for one and the same amino acid (so-called degeneration of the genetic code), the most favourable codons for the stability can be determined (so-called alternative codon usage). Depending on the amino acid to be encoded by the RNA, there are variousD possibilities for modification of the RNA sequence, compared to its wild type sequence. In the case of amino acids, which are encoded by codons, which contain exclusively G or C nucleotides, no modification of the codon is necessary. Thus, the codons for Pro (CCC or CCG), Arg (CGC or CGG), Ala (GCC or GCG) and Gly (GGC or GGG) require no modification, since no A or U is present. In contrast, codons which contain A and/or U nucleotides can be modified by substitution of other codons, which code for the same amino acids but contain no A and/ or U. Examples of these are: the codons for Pro can be modified from CCU or CCA to CCC5 or CCG: the codons for Arg can be modified from CGU or CGA or AGA or AGG to CGC or CGG; the codons for Ala can be modified from GCU or GCA to GCC or GCG; the codons for Gly can be modified from GGU or GGA to GGC or GGG. In other cases, although A or U nucleotides cannot be eliminated from the codons, it is however possible to decrease the A and U content by using codons which contain a lower content of A and/ or U nucleotides. Examples of these are: the codons for Phe can be modified from UUU to UUC; the codons for Leu can be modified from UUA. DOG, CUU or CUA to CUC or CUG; the codons for Ser can be modified fromD UGU or UCA or AGU to UCC, UCG or AGC; the codon for Tyr can be modified from UAU to UAC; the codon for Cys can be modified from UGU to UGC; the codoo for His can be modified from CAU to CAC; the codon for Gin can be modified from CAA to CAG; the codons for He can be modified from AUU or AUA to AUG; the codons for Thr can be modified from ACU or ACA to ACC or AGG; the codon for Asn can be modified from AAU to AAC; the codon for Lys can be modified from AAA to AAG; the codons for Val can be modified from GUU or GUA to GUC or BUG; the codon for Asp can be modified from GAU to GAC; the codon for Glu can be modified5 from GAA to GAG; the stop codon UAA can be modified to UAG or UGA. In the case of the codons for Met (AUG) and Trp (UGG), on the other hand, there is no possibility of sequence modification. The substitutions listed above can be used either individually or in all passible combinations to increase the G/C content of the at least one mRNA of the composition of the present invention compared to its particular wild type mRNA (i.e. the original sequence). Thus, for example, all codons for Thr occurring in the wild type sequence can be modified to ACC (or ACG). Preferably, however, for example, combinations of the above substitution possibilities are used:

substitution of all codons coding for Thr in the original sequence (wild type mRNA) to ACC (or ACG) and substitution of all codons originally coding for Ser to UCC (or UCG or AGO; substitution of all codons coding far lie in the original sequence to AUC and substitution of all codons originally coding far Lys to AAG and substitution of all codons originally coding for Tyr to UAC; substitution of all codons coding for Val in the ariginal sequence to GUC (or GUG) and sobstitution of all cadans originally coding for Glu to GAG and

substitution of all codons originally coding far Ala to GCC (or GCG) and substitution of all codons originally coding for Arg to CGC (or CGG); substitution of all codons coding for Val in the original sequence to GUC (or GUG) and substitution of all codons originally coding for Glu to GAG and substitution of all codons originally coding for Ala to GCC (or GCG) and substitution of all codons originally coding for Gly to GGC (or GGG) and substitution of all cadons originally coding for Asn to AAC; substitution of all codons coding far Val in the original sequence to GUC (or GUG) and substitution of all codons originally coding for Phe to UUC and substitution of all codons originally coding far Cys ta UGC and substitution of all codons originally coding far Leu to CUG (or CUC) and substitution of all cadons originally coding for Gin to CAG and substitution of all cadons originally coding for Pro to CCC (or CCG); etc.

Preferably, the G/C content of the coding region of the RNA of the present invention is increased by at least 7%, more preferably by at least 15%, particularly preferably by at least 2D%, compared to the G/C content of the coding region of the wild type RNA, which codes for an antigen as defined herein or a fragment or variant thereof. According ta a specific embodiment at least 5%, 10%. 20%, 30%, 40%, 50%, 60%. more preferably at least 70%, even mare preferably at least 80% and most preferably at least 90%, 95% or even 100% of the substitutable cadons in the region coding for an antigen as defined herein or a fragment or variant thereof or the whale sequence af the wild type RNA sequence are substituted, thereby increasing the GC/cantent of said sequence. In this context, it is particularly preferable to increase the G/C content of the RNA of the present invention, preferably of the at least one coding region of the RNA according to the invention, ta the maximum (i.e. 100% of the substitutable codons) as compared to the wild type sequence. According to the invention, a further preferred modification of the RNA of the present invention is based an the finding that the translation efficiency is also determined by a different frequency in the occurrence of tRNAs in cells. Thus, if so-called "rare codons" are present in the RNA of the present invention to an increased extent, the corresponding modified RNA sequence is translated to a significantly poorer degree than in the case where codons coding for relatively "frequent" tRNAs are present. According to the invention, in the modified RNA of the present invention, the region which codes for an antigen as defined herein or a fragment or variant thereof is modified compared to the corresponding region of the wild type RNA such that at least one codon of the wild type sequence, which codes for a tRNA which is relatively rare in the cell, is exchanged far a codon, which codes for a tRNA which is relatively frequent in the cell and carries the same amino acid as the relatively rare tRNA. By this modification, the sequences of the RNA of the present invention are modified such that codons for which frequently occurring tRNAs are available are inserted. In other words, according to the invention, by this modification all codons of the wild type sequence, which code for a tRNA which is relatively rare in the cell, can in each case be exchanged for a codon, which codes for a tRNA which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA. Which tRNAs occur relatively frequently in the cell and which, in contrast, occur relatively rarely is known to a person skilled in the art; cf. e.g. Akashi, Curr. Dpin. Genet. Dev. 2DDI, 1KB): GG0-BG6. The codons, which use 5 fur the particular amino acid the tRNA which occurs the most frequently, e.g. the Gly codon, which uses the tRNA, which occurs the most frequently in the (human) cell, are particularly preferred. According to the invention, it is particularly preferable to link the sequential G/C content which is increased, in particular maximized, in the modified RNA of the present invention, with the "frequent" codons without modifying the amino acid sequence uf the protein encoded by the coding region of the RNA. This preferred embodiment allows provision of a particularly efficiently translated and stabilized (modified) RNA of the present

ID invention. The determination of a modified RNA of the present invention as described above (increased G/C content; exchange of tRNAs) can be carried out using the computer program explained in WD 02/098443 - the disclosure content of which is included in its full scope in the present invention. Using this computer program, the nucleotide sequence of any desired RNA can be modified with the aid of the genetic code or the degenerative nature thereof such that a maximum G/C content results, in combination with the use of codons which code for tRNAs occurring as frequently as possible in the cell, the amino acid sequence

15 coded by the modified RNA preferably not being modified compared to the non-modified sequence. Alternatively, it is also possible to modify only the G/C content or only the codon usage compared to the original sequence. The source code in Visual Basic 6.0 (development environment used: Microsoft Visual Studio Enterprise G.D with Servicepack 3) is also described in WD 02/D38443. In a further preferred embodiment of the present invention, the A/U content in the environment of the ribosome binding site of the RNA of the present invention is increased compared tD the A/U content in the environment of the ribosome binding site of its

ZD respective wild type mRNA. This modification (an increased A/U content around the ribosome binding site) increases the efficiency of ribosome binding to the RNA. An effective binding of the ribosomes to the ribosome binding site (Kozak sequence: SEQ ID NDs: 39711, 39712; the AUG forms the start codon) in turn has the effect of an efficient translation of the RNA. According to a further embodiment of the present invention, the RNA of the present invention may be modified with respect to potentially destabilizing sequence elements. Particularly, the coding region and/or the 5' and/or 3' untranslated region of this RNA may be

25 modified compared to the respective wild type RNA such that it contains no destabilizing sequence elements, the encoded amino acid sequence of the modified RNA preferably not being modified compared to its respective wild type RNA. It is known that, for example in sequences of eukaryotie RNAs, destabilizing sequence elements (DSE) occur, to which signal proteins bind and regulate enzymatic degradation of RNA in vivo. For further stabilization of the modified RNA, optionally in the region which encodes an antigen as defined herein or a fragment or variant thereof, one or more such modifications compared to the corresponding

30 region of the wild type RNA can therefore be carried out, so that no or substantially no destabilizing sequence elements are contained there. According to the invention, DSE present in the untranslated regions (3'- and/or 5'-UTR) can also be eliminated from the RNA of the present invention by such modifications. Such destabilizing sequences are e.g. AU-rich sequences (AURES), which occur in 3'-UTR sections of numerous unstable RNAs (Caput et al„ Proc. Natl. Acad. Sci. USA I98B, 83: IB7D tD IB74). The RNA of the present invention is therefore preferably modified compared tu the respective wild type RNA such that the RNA of the

35 present invention contains no such destabilizing sequences. This also applies to those sequence motifs which are recognized by possible endonucleases. e.g. the sequence GAACAAG, which is contained in the 3'-UTR segment of the gene encoding the transferrin receptor (Binder et al., EMBO J. I3B4, 13: 19BB to 1980). These sequence motifs are also preferably removed in the NA of the present invention.

According to a preferred embodiment, the present invention provides an RNA as defined herein comprising at least one coding sequence, wherein the coding sequence comprises or consists of any one of the (modified) nucleic acid sequences defined in SEO ID NOs: 8821-13230. 39715, 3B7IB, 39717, 39720, 39721, 39724, 39725, 33728, 3B729, 39730, 33733, 3B734, 39737, 33738, 33741, 39742, 39745. 3974B, and/or SEO 10 NBs: 2B4BI-30870, and/or SEQ ID NOs: 30871-35280, and/or SEQ ID NOs: 35281- 33630, and/or SEQ ID ND: 33713 to SEQ ID N0:3974B. and/or SED ID NO: 33714, 33716, 33723, 39734. 33738, 3B725, or of a fragment or variant of any one of these sequences. In other words, the at least one coding sequence preferably comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ 10 NOs: 8821-13230, 33715, 397IB, 33717, 3972B, 39721. 33724, 33725, 33728, 33723, 39730, 39733. 39734, 39737, 39738, 39741, 39742, 39745, 3974B, and/or SEQ ID NOs: 2B46I-30870, and/or SEQ 10 NOs: 30871-35280, and/or SEQ ID NOs: 35281-33630, and/or SEQ ID NO: 33713 to SEQ 10 NO: 3974B, and/or SEQ ID NO: 39714. 39716, 39729, 33734, 39738, 39725, or a fragment or variant of any one of these nucleic acid sequences.

In a further preferred embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence identical to or having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%. 87%. 88%, 83%, 30%, 31%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%. more preferably of at least 8B%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with any one of the (modified) nucleic acid sequences defined in SEQ ID NOs: 8821-13230, 39715, 337IB, 39717, 33720, 39721. 33724, 39725, 33728, 33729. 39730. 39733, 33734, 3B737, 39738, 39741, 33742, 33745, 33746, and/or SEQ 10 NOs: 264BI-30870, and/or SEQ ID NOs: 30871-35280, and/or SEQ ID NOs: 3528I-3363D, and/or SEQ ID NO: 39713 to SEQ ID NO: 3974B. and/or SEQ 10 NOs: 39714. 337IB. 39729. 39734, 39738, 39725, or of a fragment or variant of any one of these sequences.

According to a particularly preferred embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 8B% with any one of the (modified) nucleic acid sequences defined in SEQ ID NOs: 8821-13230, 39715, 39716, 39717, 3972D, 39721, 39724, 39725, 39728, 39729, 39730, 39733, 39734, 39737, 39738, 39741, 39742, 3B745, 3374B, and/or SEQ 10 NOs: 2B46I-30870, and/or SEQ ID NOs: 30871- 35280, and/or SEQ 10 NOs: 3528I-33B90, and/or SEQ 10 NO: 39713 to SEQ ID NO: 39746, and/or SEQ ID NOs: 39714, 397IB, 39729, 39734, 39738, 39725, or of a fragment or variant of any one of these sequences.

GC optimized sequences:

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises or consists of a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 39714, 39716, 39729. 39734, 39738, 39725, or a fragment or variant of any one of these nucleic acid sequences. According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%.20%, 30%, 40%, 50%. BD%, 70%, 8D%, 85%, 86%. 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 9B%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at 5 least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NDs: 39714, 397IB. 39729, 39734, 39738, 39725, or a fragment or variant of any one of these nucleic acid sequences.

Sequences adapted to human codon usage:

ID According to the invention, a further preferred modification of the RNA of the present invention is based on the finding that codons encoding the same amino acid typically occur at different frequencies. According to the invention, in the modified RNA of the present invention, the coding sequence (coding region) as defined herein is preferably modified compared to the corresponding region of the respective wild type RNA such that the frequency of the codons encoding the same amino acid corresponds to the naturally occurring frequency of that codon according to the human codon usage as e.g. shown in Table 2.

15

For example, in the case of the amino acid alanine (Ala) present in an amino acid sequence encoded by the at least one coding sequence of the RNA according to the invention, the wild type coding sequence is preferably adapted in a way that the codon "GCC" is used with a frequency of D.4D, the codon "GCT" is used with a frequency of 0.28, the codon "GCA" is used with a frequency of 0.22 and the codon "GCG" is used with a frequency of 0.ID etc. (see Table 2).

D

Table 2: Human codon usage table

Amino acid codon fraction /10ΠΟ Amino acid codon fraction /IDDD

Ala GCG D.ID 7.4 Pro CCG 0.11 G.9

Ala GCA 0.22 15.8 Pro CCA 0.27 IB.9

Ala GCT 0.28 18.5 Pro CCT 0,29 17.5

Ala GCC* 0.4D 27.7 Pro GCC* 0.33 19.8

Cys TGT 0.42 I0.B Gin CAG* 0.73 34.2

Cys TGC* 0.58 I2.B Gin CAA 0.27 12.3

Asp GAT 0.44 21.8 Arg AGG 0.22 12.0

Asp GAC* D.5B 25.1 Arg AGA* 0.21 12.1

Glu GAG* D.59 39.B Arg CGG 0.19 11.4

Glu GAA 0.41 29.D Arg CGA 0.10 B.2

Phe TTT 0.43 I7.B Arg CGT 0.D9 4.5

Phe TTC* 0.57 20.3 Arg CGC 0.19 10.4

Gly GGG D.23 IB.5 Ser AGT 0.14 12.1 Amino acid codon fraction /1DDO Amino acid codon fraction /IDDD

Gly GGA 0.26 IG.5 Ser AGC* 0.25 19.5

Gly GGT Q.I8 10.8 SET TCG O.OG 4.4

Gly GGC* 0.33 22.2 Ser TCA 0.15 12.2

His CAT 0.41 10.9 Ser TCT 0.18 15.2

His CAC* 0.59 15.1 Ser TCC 0.23 17.7

He ATA 0.14 7.5 Thr ACG 0.12 B.I

He ATT 0.35 IG.O Thr ACA 0.27 15.1

He ATC* 0.52 20.8 Thr ACT 0.23 13.1

Lys AAG* O.GO 31.9 Thr ACC* 0.38 18.9

Lys AAA 0.40 24.4 Val GTG* 0.48 28.1

Leu TTG 0.12 12.9 Val GTA 0.10 7.1

Leu TTA O.OG 7.7 Val GTT 0.17 11.0

Leu CTG* 0.43 39.G Val GTC 0.25 14.5

Leu CTA 0.07 7.2 Trp TGG* 1 13.2

Leu cn 0.12 13.2 Tyr TAT 0.42 12.2

Leu CTC 0.20 I9.G Tyr TAC* 0.58 15.3

Met ATG* 1 22.0 Stop TG * O.GI 1.6

Asn AAT 0.44 17.0 Stop TAG 0.17 0.8

Asn AAC* D.5G 19.1 Step TAA 0.22 1.0

*: most frequent codon

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ 10 NOs: 17641-22050, or a fragment or variant of any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises Dr consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 9D% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 17641-22050, or a fragment or variant of any one of said nucleic acid sequences. Codon-optimized sequences:

As described above it is preferred according to the invention, that all codons of the wild type sequence which code for a tRNA. which is relatively rare in the cell, are exchanged for a cadon which codes for a tRNA, which is relatively frequent in the cell and which, in each case, carries the same amino acid as the relatively rare tRNA. Therefore it is particularly preferred that the mast frequent codons are used for each encoded amino acid (see Table 2, most frequent codons are marked with asterisks). Such an optimization procedure increases the codon adaptation index (CAI) and ultimately maximises the CAI. In the context of the invention, sequences with increased or maximized CAI are typically referred to as "codon-optimized" sequences and/or CAI increased and/or maximized sequences. According to a preferred embodiment, the NA of the present invention comprises at least one coding sequence, wherein the coding sequence is codon-optimized as described herein. More preferably, the codon adaptation index (CAI) of the at least one coding sequence is at least D.5, at least 0.8, at least 0.9 or at least 0.35. Most preferably, the codon adaptation index (CAI) of the at least one coding sequence is I.

For example, in the case of the amino acid alanine (Ala) present in the amino acid sequence encoded by the at least one coding sequence of the RNA according to the invention, the wild type coding seqoence is adapted in a way that the most frequent human codon "GCC" is always used for said amino acid, or for the amino acid Cysteine (Cys), the wild type sequence is adapted in a way that the most frequent human cndnn "TGC" is always used for said amino acid etc.

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting nf SEQ ID NOs: 2205I-2G4B0, D a fragment or variant nf any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%, 30%, 40%, 50%, B0%, 70%, 80%, 85%, 86%. 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 80%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 22051-26460, Dr a fragment or variant of any one of said nucleic acid sequences.

C-optimized sequences:

According to another embodiment, the RNA of the composition Df the present invention may be modified by modifying, preferably increasing, the cytosine (C) content of the RNA, preferably of the coding region of the RNA.

In a particularly preferred embodiment of the present invention, the C content of the coding region of the RNA of the present invention is modified, preferably increased, compared to the C content of the coding region of the respective wild type RNA, i.e. the unmodified RNA. The amino acid sequence encoded by the at least one coding sequence of the RNA of the present invention is preferably not modified as compared to the amino acid sequence encoded by the respective wild type mRNA. In a preferred embodiment of the present invention, the modified RNA is modified such that at least 10%, 20%, 30%, 40%, 50%, 00%, 70% or 80%. or at least 90% of the theoretically possible maximum cytosine-content or even a maximum cytosine-cDntent is achieved.

In further preferred embodiments, at least 10%, 20%, 30%, 40%, 50%, 60%. 70%, 80%, 90% or even 100% of the codons of the target RNA wild type sequence, which are "cytosine content optimizable" are replaced by codons having a higher cytosine- content than the ones present in the wild type sequence. In a further preferred embodiment, some of the codons of the wild type coding sequence may additionally be modified such that a codnn for a relatively rare tRNA in the cell is exchanged by a codon for a relatively frequent tRNA in the cell, provided that the substituted codon for a relatively frequent tRNA carries the same amino acid as the relatively rare tRNA of the original wild type codon. Preferably, all of the codons for a relatively rare tRNA are replaced by a codon for a relatively frequent tRNA in the cell, except codons encoding amino acids, which are exclusively encoded by codons not containing any cytosine, or except for glutamine (Gin), which is encoded by two codons each containing the same number of cytosines.

In a further preferred embodiment of the present invention, the modified target RNA is modified such that at least 80%, or at least 90% of the theoretically passible maximum cytosine-content or even a maximum cytosine-content is achieved by means of codons, which code for relatively frequent tRNAs in the cell, wherein the amino acid sequence remains unchanged.

Due to the naturally occurring degeneracy of the genetic code, more than one codon may encode a particular amioo acid. Accordingly, 18 out of 20 naturally occurring amino acids are encoded by more than one codnn (with Tryp and Met being an exception), e.g. by 2 codons (e.g. Cys, Asp, Glu), by three codons (e.g. lie), by 4 codons (e.g. Al, Gly, Pro) or by G codons (e.g. Leu, Arg, Ser). However, not all codons encoding the same amino acid are utilized with the same frequency under in vivo conditions. Depending on each single organism, a typical codon usage profile is established.

The term "cytosine content-optimizable codon" as used within the context of the present invention refers to codons, which exhibit a lower content of cytosines than other codons encoding the same amino acid. Accordingly, any wild type codon, which may be replaced by another codon encoding the same amino acid and exhibiting a higher number of cytosines within that codon, is considered to be cytosine-optimizable (C-optimizable). Any such substitution of a C-optimizable wild type codon by the specific C-optimized codon within a wild type coding region increases its overall C content and reflects a C-enriched modified mRNA sequence. According to a preferred embodiment, the RNA of the present invention, preferably the at least one coding sequence of the RNA of the present invention comprises or consists of a C-maximized RNA sequence containing C-optimized codons for all potentially C-optimizable codons. Accordingly, I0D% or all of the theoretically replaceable C-optimizable codons are preferably replaced by C-optimized codons over the entire length of the coding region. In this context, cytosine-content optimizable codons are codons, which contain a lower nomber of cytosines than other codons coding for the same amino acid. Any of the codons GCG, GCA, GCU codes for the amino acid Ala, which may be exchanged by the codon GCC encoding the same amino acid, and/ or the codon UGU that codes for Cys may be exchanged by the codon UGC encoding the same amino acid, and/or the codon GAU which codes for Asp may be exchanged by the codon GAC encoding the same amino

5 acid, and/or the codon that UUU that codes for Phe may be exchanged for the codon UUC encoding the same amino acid, and/or any of the codons GGG, GGA, GGU that code Gly may be exchanged by the codon GGC encoding the same amino acid, and/or the codon CAU that codes for His may be exchanged by the codon CAC encoding the same amino acid, and/ or any of the codons AUA, AUU that code for He may be exchanged by the codon AUC, and/or any of the codons UUG, UUA, CUG, CUA, CUU coding for Leu may be exchanged by the codon CUC encoding the same amino acid, and/or the codon AAU that codes for Asn may be exchanged

ID by the codon AAC encoding the same amino acid, and/or any of the codons CCG, CCA, CCU coding for Pro may be exchanged by the codon CCC encoding the same amino acid, and/ or any of the codons AGG, AGA, CGG, CGA, CGU coding for Arg may be exchanged by the codon CGC encoding the same amino acid, and/or any of the codons AGU, AGC, UCG, UCA, UCU coding for Ser may be exchanged by the codon UCC encoding the same amino acid, and/or any of the codons ACG, ACA, ACU coding for Thr may be exchanged by the codon ACC encoding the same amino acid, and/or any of the codons GUG, GUA, GUU coding for Val may be

15 exchanged by the codon GUC encoding the same amino acid, and/or the codon UAU coding for Tyr may be exchanged by the codon UAC encoding the same amino acid.

In any of the above instances, the number of cytosines is increased by I per exchanged codon. Exchange of all non C-optimized codons (corresponding to C-optimizable codons) of the coding region results in a C-maximized coding sequence. In the contextD of the invention, at least 70%, preferably at least 80%, more preferably at least 90%, of the non C-optimized codons within the at least one coding region of the NA according to the invention are replaced by C-optimized codons.

It may be preferred that for some amino acids the percentage of C-optimizable codons replaced by C-optimized codons is less than 70%, while for other amino acids the percentage of replaced codons is higher than 70% to meet the overall percentage of5 C-optimization of at least 70% of all C-optimizable wild type codons of the coding region.

Preferably, in a C-optimized RNA of the invention, at least 50% of the C-optimizable wild type codons for any given amino acid are replaced by C-optimized codons, e.g. any modified C-enriched RNA preferably contains at least 50% C-optimized codons at C-optimizable wild type codon positions encoding any one of the above mentioned amino acids Ala, Cys, Asp, Phe, Gly, His, He, Leu,0 Asn, Pro, Arg, Ser, Thr, Val and Tyr, preferably at least 60%.

In this context codons encoding amino acids, which are not cytosine content-optimizable and which are, however, encoded by at least two codons, may be used without any further selection process. However, the codon of the wild type sequence that codes for a relatively rare tRNA in the cell, e.g. a human cell, may be exchanged for a codon that codes for a relatively frequent tRNA5 in the cell, wherein both code for the same amino acid. Accordingly, the relatively rare codon GAA coding for Glu may be exchanged by the relative frequent codon GAG coding for the same amino acid, and/or the relatively rare codon AAA coding for Lys may be exchanged by the relative frequent codon AAG coding for the same amino acid, and/or

the relatively rare codon CAA coding for Gin may be exchanged for the relative frequent codon CAG encoding the same amino acid.

In this context, the amino acids Met (AUG) and Trp (UGG), which are encoded by only one codon each, remain unchanged. Stop codons are not cytosine-content optimized; however, the relatively rare stop codons amber, ochre (UAA, UAG) may be exchanged by the relatively frequent stop codon opal (UGA).

The single substitutions listed above may bE used individually as well as in all possible combinations in order to optimize the cytosine-content of the modified RNA compared to the wild type mRNA sequence.

Accordingly, the at least one coding sequence as defined herein may be changed compared to the coding region of the respective wild type RNA in such a way that an amino acid encoded by at least two or more codons, of which one comprises one additional cytosine, such a codon may be exchanged by the C-optimized codon comprising one additional cytosine. wherein the amino acid is preferably unaltered compared to the wild type sequence.

In a preferred embodiment, the present invention provides an RNA comprising at least one coding sequence, wherein the coding sequence comprises a nucleic acid sequence selected from the group consisting of SEQ ID NDs: 13231-17640, or a fragment or variant of any one of said nucleic acid sequences.

According to a further embodiment, the at least one coding sequence of the RNA according to the invention comprises or consists of a nucleic acid sequence having a sequence identity of at least 5%, 10%, 20%.30%, 40%, 50%, 60%.70%, 80%, 85%, 8G%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99%, preferably of at least 70%, more preferably of at least 8D%, even more preferably at least 85%, even more preferably of at least 90% and most preferably of at least 95% or even 97%, with a nucleic acid sequence selected from the group consisting of SEQ ID NDs: 13231-17640, or a fragment or variant of any one of said nucleic acid sequences.

According to a particularly preferred embodiment, the invention provides an RNA, preferably an mRNA, comprising at least one coding sequence as defined herein, wherein the G/C content of the at least one coding sequence of the RNA is increased compared to the G/C content of the corresponding coding sequence of the corresponding wild type RNA, and/or wherein the C content of the at least one coding sequence of the RNA is increased compared to the G content of the corresponding coding sequence of the corresponding wild type RNA. and/or wherein the codons in the at least one coding sequence of the RNA are adapted to human codon usage, wherein the codon adaptation index (CAI) is preferably increased or maximised in the at least one coding sequence of the RNA, and wherein the amino acid sequence encoded by the RNA is preferably not being modified compared to the amino acid sequence encoded by the corresponding wild type RNA. 5'-cap structure:

Modification af the S'-end of a modified artificial nucleic acid:

According to another preferred embodiment of the invention, the artificial nucleic acid, preferably an mRNA, as defined herein, 5 can be modified by the addition of a so-called "5'-cap" structure, which preferably stabilizes the nucleic acid, preferably an mRNA, as described herein.

In a particularly preferred embodiment, the artificial nucleic acid according to the invention, preferably an mRNA, comprises a 5'-cap structure.

ID

A 5'-cap is an entity, typically a modified nucleotide entity, which generally "caps" the 5'-end of a nucleic acid, for example of a mature mRNA. A 5'-cap may typically be formed by a modified nucleotide, particularly by a derivative of a guanine nucleotide. Preferably, the 5'-cap is linked to the 5'-terminus via a 5'-5'-triphosphate linkage. A 5'-cap may be methylated, e.g. m7GpppN, wherein N is the terminal 5' nucleotide of the nucleic acid carrying the 5'-cap, typically the S'-end of an mRNA. m7GpppN is the I5 5'-cap structure, which naturally occurs in mRNA transcribed by polymerase II and is therefore preferably not considered as modification comprised in an artificial nucleic acid in this context. Accordingly, a modified artificial nucleic acid, preferably an mRNA, of the present invention may comprise an m7GpppN as 5'-cap, but additionally the modified artificial nucleic acid, preferably an mRNA, typically comprises at least one further modification as defined herein. D Further examples of 5'cap structures include glyceryl, inverted deaxy abasic residue (moiety), 4',5' methylene nucleotide, I- (beta-D-erythrofuranosyl) nucleotide, 4'-thio nucleotide, carbocyclic nucleotide, l,5-anhydrohexitol nucleotide, L-nucleatides, alpha-nucleotide, modified base nucleotide, threo-pentofuranosyl nucleotide, acyclic 3',4'-seco nucleotide, acyclic 3,4- dihydroxybutyl nucleotide, acyclic 3,5 dihydroxypentyl nucleotide.3'-3'-inverted nucleotide moiety, 3'-3'-inverted abasic moiety, 3'-2'-invertBd nucleotide moiety, 3'-2'-inverted abasic moiety, l,4-butanediol phosphate, 3'-phosphoramidate, hexylphasphate,5 aminohexyl phosphate, 3'-phosphate, 3'phosphorothioate, phosphorodithioate, or bridging or non-bridging methylphosphonate moiety. These modified 5'-cap structures are regarded as at least one modification in this context.

Particularly preferred modified 5'-cap structures are capl (methylation of the ribose of the adjacent nucleotide of m7G), cap2 (additional methylation of the ribose of the 2nd nucleotide downstream of the m7G), cap3 (additional methylation of the ribose ofD the 3rd nucleotide downstream of the m7G), cap4 (additional methylation of the ribose of the 4th nucleotide downstream of the m7G), ARCA (anti-reverse cap analogue, modified ARCA (e.g. phosphothioate modified ARCA), inosine, Nl-methyl-guanosine, 2'- fluoro-guanosine, 7-deaza-guanosine, 8-oxo-guanosine, 2-amino-guanosine. LNA-guanosine. and 2-azido-guanosine.

S'-UTRs:

5 According to a further embodiment, the artificial nucleic acid comprises an untranslated region (UTR). More preferably, the artificial nucleic acid according to the invention, preferably an mRNA. comprises at least one of the following structural elements: a 5'- and/or 3'- untranslated region element (UTR element), particularly a 5'-UTR element, which comprises or consists of a nucleic acid sequence which is derived from the 5'-UTR of a TOP gene or from a fragment, homolog or a variant thereof, or a 5'- and/ or 3'-UTR element which may be derivable from a gene that provides a stable mRNA or from a homolog, fragment or variant thereof; a histone-stem-loop structure, preferably a histone-stem-loop in its 3' untranslated region; a 5'-cap structure; a poly- 5 A tail; or a poly(C) sequence.

In a preferred embodiment, the artificial nucleic acid, preferably an mRNA, comprises at least one 5'- or 3'-UTR element. In this context, an UTR element comprises or consists of a nucleic acid sequence, which is derived from the 5'- or 3'-UTR of any naturally occurring gene or which is derived from a fragment, a homolog or a variant of the 5'- or 3'-UTR of a gene. Preferably the 5'- or ID 3'-UTR element used according to the present invention is heterologous to the coding region of the inventive artificial nucleic acid. Even if 5'- or 3'-UTR elements derived from naturally occurring genes are preferred, also synthetically engineered UTR elements may be used in the context of the present invention.

According to a preferred embodiment, the artificial nucleic acid according to the invention comprises a 5'-UTR. More preferably, 15 the artificial nucleic acid comprises a 5'-UTR comprising at least one heterologous 5'-UTR element.

In a particularly preferred embodiment, the artificial nucleic acid comprises at least one 5'-untranslated region element (5'-UTR element), preferably a heterologous 5'-UTR element, which comprises or consists of a nucleic acid sequence, which is derived from the 5'-UTR of a TOP gene or which is derived from a fragment, homolog or variant of the 5'-UTR of a TOP gene.

ZD

It is particularly preferred that the 5'-UTR element does not comprise a TDP-motif Dr a 5'TQP, as defined above.

In some embodiments, the nucleic acid sequence of the 5'-UTR element, which is derived from a 5'-UTR of a TDP gene, terminates at its 3'-end with a nucleotide located at position I, Z, 3, 4, 5, G, 7, 8, 9 or ID upstream of the start codon (e.g. A(U/T)G) of the 25 gene or mRNA it is derived from. Thus, the 5'-UTR element does not comprise any part of the protein coding region. Thus, preferably, the only protein coding part of the artificial nucleic acid is provided by the at least one coding region.

The nucleic acid sequence, which is derived from the 5'-UTR of a TDP gene, is typically derived from a eukaryotic TDP gene, preferably a plant or animal TDP gene, more preferably a chardate TDP gene, even more preferably a vertebrate TDP gene, most 3D preferably a mammalian TDP gene, such as a human TDP gene.

For example, the 5'-UTR element is preferably selected from 5'-UTR elements comprising or consisting of a nucleic acid sequence, which is derived from a nucleic acid sequence selected from the group consisting of SED ID NDs: I-I3B3, SED ID NO: 1305, SED ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, whose disclosure is incorporated herein by reference, 35 from the homologs of SEQ ID NDs: 1-1363, SEQ ID NO: 1395, SEO ID ND: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, from a variant thereof, or preferably from a corresponding RNA sequence. The term "homologs of SEQ ID NDs: I- 1363, SEQ ID NO: I3B5, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700" refers to sequences of other species than homo sapiens, which are homologous to the sequences according to SEQ ID NDs: I-I3B3, SEQ ID NO: 1305, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, In a preferred embodiment, the 5'-UTR element of the artificial nucleic acid, preferably an mRNA, comprises or consists of a nucleic acid sequence, which is derived from a nucleic acid sequence extending from nucleotide position 5 (i.e. the nucleotide that is located at position 5 in the sequence) to the nucleotide position immediately 5' to the start codon (located at the 3' end of the sequences), e.g. the nucleotide position immediately 5' to the ATG sequence, of a nucleic acid sequence selected from SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, from the homologs of SEQ 10 NOs: 1-1363, SEQ ID NO: I3B5, SEQ 10 NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700 from a variant thereof, or a corresponding RNA sequence. It is particularly preferred that the 5'-0TR element is derived from a nucleic acid sequence extending from the nucleotide position immediately 3' to the 5T0P to the nucleotide position immediately 5' to the start codon (located at the 3'-end of the sequences), e.g. the nucleotide position immediately 5' to the ATG sequence, of a nucleic acid sequence selected from SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, from the homologs of SEQ ID NOs: 1-1363, SEQ ID NO: 1395, SEQ ID NO: 1421 and SEQ ID NO: 1422 of the patent application WO 2013/143700, from a variant thereof, or a corresponding RNA sequence.

In a particularly preferred embodiment, the 5'-UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5'-UTR of a TOP gene encoding a ribosomal protein or from a variant of a 5'-UTR of a TOP gene encoding a ribosomal protein. For example, the 5'-0TR element comprises or consists of a nucleic acid sequence, which is derived from a 5'-UTR of a nucleic acid sequence according to any of SEQ ID NO: 67, 170, 193, 244, 259, 554, 650, 675, 700, 721, 913, 1016, 1063, 1120, 1138. and 1284-1360 of the patent application W02DI3/I43700, a corresponding RNA sequence, a homolog thereof, or a variant thereof as described herein, preferably lacking the STOP motif. As described above, the sequence extending from position 5 to the nucleotide immediately 5' to the ATG (which is located at the 3'-end of the sequences) corresponds to the 5'-UTR of said sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SEQ 10 NOs: 1-4410, or a fragment or variant of any of these sequences, wherein these sequences resemble VPI protein sequences. In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NOs: 4411-8820, 39713, 30714, 3B7I8, 39719, 39722, 39723, 39726, 39727, 39731, 39732, 39735, 39736, 39739, 39740, 39743 and 39744, or a fragment or variant of any of these sequences, wherein these sequences resemble VPI nucleotide wild type sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NOs: 8821-13230, 39715, 3B7I6, 33717, 39720, 33721, 33724, 33725. 39728, 33723, 33730, 39733, 39734, 39737, 39738, 39741, 39742, 39745, 3974G. and/or SEQ ID NDs: 26461-30870, and/or SEQ ID NOs: 30871-35280, and/or SEQ ID NOs: 35281-39630, and/or SEQ ID N0:397I3 to SEQ ID N0:39746, and/or SEQ ID NO: 39714, 39716, 39729, 39734, 39738, 39725, or a fragment or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NDs: I323I-I7B4D, or a fragment 5 or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NDs: I7B4I-22050. or a fragment or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

ID In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NDs: 22D5I-2B4BD, or a fragment or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SED ID NDs: 2B4BI-3D87D, or a fragment or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

15

In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NDs: 3D87I-3528Q, or a fragment or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

In one embodiment, the sequences of the invention are selected from the group of any of SEQ ID NDs: 35281-39690, or a fragmentD or variant of any of these sequences, wherein these sequences resemble optimized VPI nucleotide wild type sequences.

Preferably, the artificial nucleic acid according to the invention comprises a 5'-UTR comprising at least one heterologous 5'-DTR sequence, wherein the at least one heterologous 5'-UTR element comprises a nucleic acid sequence, which is derived from a 5'- UTR of a TOP gene encoding a ribosomal protein, preferably from a corresponding RNA sequence, or from a homolog, a fragment5 or a variant thereof, preferably lacking the 5'TOP motif.

Preferably, the 5'-UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5'-DTR of a TOP gene encoding a ribosomal Large protein (RPL) or from a homolog Dr variant of a 5'-UTR of a TDP gene encoding a ribosomal Large protein (RPL). For example, the 5'-UTR element comprises or consists of a nucleic acid sequence, which is derived from a 5'-DTRD of a nucleic acid sequence according to any of SEQ ID NDs: 67, 259, 1284-1318, 1344, 1346, 1348-1354, 1357, 1358, 1421 and 1422 of the patent application WD 2013/143700, a corresponding RNA sequence, a homolog thereof, or a variant thereof as described herein, preferably lacking the 5'TOP motif.

In a particularly preferred embodiment, the 5'-UTR element comprises or consists of a nucleic acid sequence, which is derived5 from the 5'-0TR of a ribosomal protein Large 32 gene, preferably from a vertebrate ribosomal protein Large 32 (L32) gene, more preferably from a mammalian ribosomal protein Large 32 (L32) gene, most preferably from a human ribosomal protein Large 32 (L32) gene, or from a variant of the 5'-UTR of a ribosomal protein Large 32 gene, preferably from a vertebrate ribasomal protein Large 32 (L32) gene, more preferably from a mammalian ribosomal protein Large 32 (L32) gene, most preferably from a human ribosomal protein Large 32 (L32) gene, wherein preferably the 5'-UTR element does not comprise the 5'TOP of said gene.

Accordingly, in a particularly preferred embodiment, the 5'-UT element comprises or consists of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 00%, even more preferably of at least about 95%, even more preferably of at least about 03% to the nucleic acid sequence according to SEO ID NO: 20649 (5'-UTR of human ribosomal protein Large 32 lacking the 5'-terminal oligopyrimidine tract; corresponding to SEO ID NO: 1368 of the patent application W02013/143700) or preferably to a corresponding RNA sequence, such as SEO ID NO: 39692, or wherein the at least one 5'-UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 7D%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to the nucleic acid sequence according to SEQ ID NO: 39691, or more preferably to a corresponding RNA sequence, such as SEO ID NO: 39692, wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5'-UT . Preferably, the fragment exhibits a length of at least about 20 nucleotides or more, preferably of at least about 30 nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

In some embodiments, the artificial nucleic acid according to the invention comprises a 5'-0TR element, which comprises or consists of a nucleic acid sequence, which is derived from the 5'-0TR of a vertebrate TOP gene, such as a mammalian, e.g. a human TOP gene, selected from RPSA, RPS2, RPS3, RPS3A, RPS4, RPS5. RPS6, RPS7, RPS8. RPS9, RPSI0, RPSII, RPSI2, RPSI3, RPSI4, RPSI5, RPSI5A, RPSI6, RPSI7, RPSI8, RPSI9, RPS20, RPS2I. RPS23, RPS24, RPS25, RPS26, RPS27, RPS27A, RPS28, RPS29, RPS30, RPL3, RPL4, RPL5, RPL6, RPL7, RPL7A, RPL8, RPL9, RPLI0, RPLI0A, RPLII. RPLI2, RPLI3, RPLI3A, RPLI4, RPLI5, RPLI7, RPLI8, RPLI8A, RPLI9, RPL2I, RPL22, RPL23, RPL23A, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL30, RPL3I, RPL32, RPL34, RPL35, RPL35A, RPL36, RPL36A, RPL37, RPL37A, RPL38, RPL39, RPL40, RPL4I. RPLP0, RPLPI, RPLP2, RPLP3, RPLP0, RPLPI, RPLP2, EEFIAI, EEFIB2, EEFID, EEFIG, EEF2, EIF3E, EIF3F, EIF3H, EIF2S3, EIF3C, EIF3K, EIF3EIP, EIF4A2, PABPCI, HNRNPAI, TPTI, TUBBI, 0BA52, NP I. ATP5G2, GNB2LI, NME2, UQCRB, or from a homolog or variant thereof, wherein preferably the 5'-0TR element does not comprise a TDP-motif or the 5'TOP of said genes, and wherein optionally the 5'-UTR element starts at its 5'-end with a nucleotide located at position 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 downstream of the 5'-terminal oligopyrimidine tract (TOP) and wherein further optionally the 5'-UTR element which is derived from a 5'-0TR of a TOP gene terminates at its 3'-end with a nucleotide located at position I, 2, 3, 4, 5, 6, 7, 8, 9 or ID upstream of the start codon (A(U/T)G) of the gene it is derived from. According to a preferred embodiment, the artificial nucleic acid comprises at least one heterologous 5'-UTR element comprising a nucleic acid sequence, which is derived from a 5'-0TR of a TDP gene encoding a ribosomal Large protein (RPL), preferably PL32 or RPL35A, ar from a gene selected from the group consisting of HSDI7B4, ATP5AI, AIGI. ASAHI, CDXBC or ABCB7 (also referred to herein as MDR), or from a homolog, a fragment or variant of any one of these genes, preferably lacking the 5'TDP motif.

5 In further particularly preferred embodiments, the 5'-UTR element comprises or consists of a nucleic acid sequence, which is derived from the 5'-UTR of a ribosomal protein Large 32 gene (RPL32). a ribosomal protein Large 35 gene (RPL35), a ribosomal protein Large 21 gene (RPL2I), an ATP synthase, H+ transporting, mitochondrial Fl complex, alpha subunit I, cardiac muscle (ATP5AI) gene, an hydroxysteroid (17-beta) dehydrogenase 4 gene (HSDI7B4), an androgen-induced I gene (AIGI), cytochrome c oxidase subunit Vic gene (CDXBC), a N-acylsphingosine amidohydrolase (acid ceramidase) I gene (ASAHI), or an ATP-Binding

ID Cassette, Sub-Family B (MDR/TAP), Member 7 gene (ABCB7), or from a variant thereof, preferably from a vertebrate ribosomal protein Large 32 gene (RPL32), a vertebrate ribosomal protein Large 35 gene (RPL35), a vertebrate ribosomal protein Large 21 gene (RPL2I), a vertebrate ATP synthase, H+ transporting, mitochondrial Fl complex, alpha subunit I, cardiac muscle (ATP5AI) gene, a vertebrate hydroxysteroid (17-beta) dehydrogenase 4 gene (HSDI7B4), a vertebrate androgen-induced I gene (AIGI), a vertebrate cytochrome c oxidase subunit Vic gene (CDXBC), a vertebrate N-acylsphingosine amidohydrolase (acid ceramidase)

15 I gene (ASAHI), or a vertebrate ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 gene (ABCB7), or from a variant thereof, more preferably from a mammalian ribosomal protein Large 32 gene (RPL32), a ribosomal protein Large 35 gene (RPL35), a ribosomal protein Large 21 gene (RPL2I), a mammalian ATP synthase, H+ transporting, mitochondrial Fl complex, alpha subunit I, cardiac muscle (ATP5AI) gene, a mammalian hydroxysteroid (17-beta) dehydrogenase 4 gene (HSDI7B4), a mammalian androgen-induced I gene (AIGI), a mammalian cyto-chrome c oxidase subunit Vic gene (CDXBC), a mammalian N-acylsphingosine0 ami-dohydrolase (acid ceramidase) I gene (ASAHI), or a mammalian ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 7 gene (ABCB7), or from a variant thereof, most preferably from a human ribosomal protein Large 32 gene (RPL32), a human ribosomal protein Large 35 gene (RPL35), a human ribosomal protein Large 21 gene (RPL2I), a human ATP synthase. H+ transporting, mitochondrial Fl complex, alpha subunit I, cardiac muscle (ATP5AI) gene, a human hydroxysteroid (17-beta) dehydrogenase 4 gene (HSDI784), a human androgen-induced I gene (AIGI), a human cytochrome c oxidase subunit Vic gene5 (CDXBC), a human N-acylsphingosine amidohydrolase (acid ceramidase) I gene (ASAHI), or a human ATP-Binding Cassette, Sub- Family B (MDR/TAP). Member 7 gene (ABCB7), or from a variant thereof, wherein preferably the 5'-DTR element does not comprise the 5'TDP of said gene.

Accordingly, in a particularly preferred embodiment, the 5'-UTR element comprises or consists of a nucleic acid sequence, whichD has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 30%, even more preferably of at least about 95%, even more preferably of at least about 93% to the nucleic acid sequence according to SED ID NO: I3G8, or SED ID NOs: 1412-1420 of the patent application WD 2013/143700, or a corresponding RNA sequence, or wherein the at least one 5'-UTR element comprises or consists of a fragment of a nucleic acid sequence which has an identity of at least about 40%, preferably5 of at least about 50%, preferably of at least about 60%. preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 39% to the nucleic acid sequence according to SEQ ID NO: 1368. or SEQ ID NDs: 1412-1420 of the patent application WD 20I3/I437DD, wherein, preferably, the fragment is as described above, i.e. being a continuous stretch of nucleotides representing at least 20% etc. of the full-length 5'-UTR. Preferably, the fragment exhibits a length of at least about 2D nucleotides or more, preferably of at least about 3D nucleotides or more, more preferably of at least about 40 nucleotides or more. Preferably, the fragment is a functional fragment as described herein.

According to a particularly preferred embodiment, the artificial nucleic acid comprises a 5'-UTR comprising at least one heterologous 5'-0TR element, wherein the heterologous 5'-0TR element comprises a nucleic acid sequence according to SEO ID ND: 39G9I to SEO ID ND: 39FJ94. or a homolog, a fragment or a variant thereof. Preferably, the at least one heterologous 5'-UTR element comprises or consists of a nucleic acid sequence, which has an identity of at least about 40%, preferably of at least about 50%, preferably of at least about 60%, preferably of at least about 70%, more preferably of at least about 80%, more preferably of at least about 90%, even more preferably of at least about 95%, even more preferably of at least about 99% to a nucleic acid sequence according to any one of SEQ ID NO: 33631 to SEQ ID ND: 39694. According to a preferred embodiment, the artificial nucleic acid according to the invention comprises a 3'-untranslated region (S'-UTR). More preferably, the artificial nucleic acid according to the invention comprises a 3'-0TR comprising or consisting of at least one heterologous 3'-0TR element, preferably as defined herein.

Poly(A) sequence and Poly(C) sequence:

According to a further preferred embodiment, the artificial nucleic acid, preferably the 3'-UTR, may contain a poly-A tail of typically about ID to 200 adenosine nucleotides, preferably about ID to 100 adenosine nucleotides, more preferably about 40 to 8D adenosine nucleotides or even more preferably about 50 to 7D adenosine nucleotides.

Preferably, the poly(A) sequence in the artificial nucleic acid, preferably an mRNA, is derived from a DNA template by in vitro transcription. Alternatively, the poly(A) sequence may also be obtained in vitro by common methods of chemical-synthesis without being necessarily transcribed from a DNA progenitor. Moreover, poly(A) sequences, or poly(A) tails may be generated by enzymatic polyadenylation of the RNA according to the present invention using commercially available polyadenylation kits and corresponding protocols known in the art, or using immobilized poly(A)polymerases e.g. in a polyadenylation reactor (WD 2016/174271).

Alternatively, the artificial nucleic acid, preferably an mRNA, optionally comprises a polyadenylation signal, which is defined herein as a signal, which conveys polyadenylation to a (transcribed) mRNA by specific protein factors (e.g. cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors I and II (CF I and CF II), poly(A) polymerase (PAP)). In this context, a consensus polyadenylation signal is preferred comprising the NN(U/T)ANA consensus sequence. In a particularly preferred aspect, the polyadenylation signal comprises one of the following sequences: AA(U/T)AAA or A(0/T)(U/T)AAA (wherein uridine is usually present in RNA and thymidine is usually present in DNA). According to a further preferred embodiment, the artificial nucleic acid of the present invention, preferably the S'-UTR of the artificial nucleic acid, may contain a poly-C tail of typically about ID to 20D cytosine nucleotides, preferably about ID to IDO cytosine nucleotides, more preferably about 20 to 70 cytosine nucleotides or even more preferably about 20 to GO or even 10 to 40 cytosine nucleotides.

3'-UT s:

In a further preferred embodiment, the artificial nucleic acid according to the invention further comprises at least one S'-UTR element, which comprises or consists of a nucleic acid sequence derived from the 3'-UTR of a chordate gene, preferably a vertebrate genE, more preferably a mammalian gene, most preferably a human gene, or from a variant of the 3'-UT of a chordate gene, preferably a vertebrate gene, more preferably a mammalian gene, most preferably a human gene.

The tfirm "3'-0TR element" refers to a nucleic acid sequence, which comprises or consists of a nucleic acid sequence that is derived from a 3'-UTR or from a variant of a S'-UTR. A 3'-DTR element in the sense of the present invention may represent the 3'-DTR on a DNA or on an RNA level. Thus, in the sense of the present invention, preferably, a 3'-DTR element may be the 3'-UTR of an mRNA, preferably nf an artificial mRNA, or it may be the transcription template for a 3'-UTR of an mRNA. Thus, a 3'-UTR element preferably is a nucleic acid sequence, which corresponds to the 3'-UTR of an mRNA, preferably to the S'-UTR of an artificial mRNA, such as an mRNA obtained by transcription of a genetically engineered vector construct. Preferably, the 3'-UTR element fulfils the function of a 3'-UTR or encodes a sequence, which fulfils the function of a 3'-DTR.

Preferably, the artificial nucleic acid comprises a 3'-UTR element comprising or consisting of a nucleic acid sequence derived from a S'-UTR of a gene, which preferably encodes a stable mRNA, or from a homolog, a fragment Dr a variant of said gene. In particular, the 3'-UTR element may be derivable from a gene that relates to an mRNA with an enhanced half-life (that provides a stable mRNA), for example a 3'-UTR element as defined and described below.

In a particularly preferred embodiment, the 3'-UTR element comprises or consists of a nucleic acid sequence which is derived from a 3'-UTR of a gene selected from the group consisting of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(1) gene, or from a homolog, a fragment or a variant of a 3'-DTR of a gene selected from the group consisting of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(1) gene. More preferably, the 3'-DTR element comprises or consists of a nucleic acid sequence which is derived from a 3'-UTR of a gene selected from the group consisting of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(1) gene, or from a homolog, a fragment or a variant of a 3'-UTR of a gene selected from the group consisting of an albumin gene, an α-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, such as a collagen alpha 1(1) gene according to SE0 ID NOs: I3G9-I300 of the patent application WD 2013/143700, whose disclosure is incorporated herein by reference, or from a homalag, a fragment or a variant thereof.

In a particularly preferred embodiment, the 3'-0TR element comprises or consists of a nucleic acid sequence, which is derived from the 3'-UTR of a vertebrate albumin gene or from a variant thereof, preferably from the 3'-0TR of a mammalian albumin gene or from a variant thereof, more preferably from the S'-UT of a human albumin gene or from a variant thereof, even more preferably from the 3'-0TR of the human albumin gene according to Genbank Accession number NM_000477.5, or from a fragment or variant thereof. More preferably, the 3'-UTR element comprises or consists of a nucleic acid according to SEO ID NO: 39703, or SEO ID NO: 39704 (corresponding to SEQ ID NO: I3B9 of the patent application WO 2013/143700), or a fragment, homolog or variant thereof.

Most preferably the 3'-0TR element comprises or consists of the nucleic acid sequence derived from a fragment of the human albumin gene according to SEQ ID NO: 39705, or SEO ID NO: 39706 (corresponding to SEQ ID NO: I37G of the patent application W0 2013/143700), or a fragment, homolog or variant thereof. Further preferably, the 3'-0TR element comprises or consists of a nucleic acid according to SEO ID NO: 39707, or SEQ ID NO: 397D8, (Albumin 7), or a fragment, homolog or variant thereof.

In another particularly preferred embodiment, the at least one heterologous 3'-0TR element comprises or consists of a nucleic acid sequence derived from a 3'-UTR of an a-globin gene, preferably a vertebrate a-or β-globin gene, more preferably a mammalian a-or β-globin gene, most preferably a human a-or β-globin gene.

More preferably, the 3'-0TR element comprises or consists of a nucleic acid according to SEQ ID NO: 39G95, or SEQ ID NO: 39G9B (corresponding to SEQ ID NO: 1370 of the patent application W0 2013/143700). or a homolog, a fragment, or a variant thereof

Preferably, the at least one heterologous 3'-0TR element comprises or consists of a nucleic acid sequence derived from a 3'- 0TR of Homo sapiens hemoglobin, alpha I (HBAI). More preferably, the 3'-0TR element comprises or consists of a nucleic acid according to SEQ ID ND: 39695, or SEQ ID NO: 3969G (corresponding to SEQ ID NO: I37D of the patent application W0 2013/143700), or a homolog, a fragment, or a variant thereof.

In another embodiment, the at least one heterologous 3'-UTR element comprises or consists of a nucleic acid sequence derived from a 3'-UTR of Homo sapiens hemoglobin, alpha 2 (HBA2). More preferably, the 3'-UTR element comprises or consists of a nucleic acid according to SEQ ID NO: 39697 or SEO ID NO: 39698 (corresponding to SEQ ID NO: 1371 of the patent application W0 20I3/I4370D), or a homolog, a fragment, or a variant thereof.

According to another embodiment, the at least one heterologous 3'-0TR element comprises or consists of a nucleic acid sequence derived from a 3'-0TR of Homo sapiens hemoglobin, beta (HBB). More preferably, the 3'-0TR element comprises or consists of a nucleic acid according to SEQ ID NO: 39609, or SED ID NO: 39700 (corresponding to SEO ID NO: 1372 of the patent application WO 2013/143700), or a homolog, a fragment, or a variant thereof.

The at least one heterologous 3'-DTR element may further comprise or consist of the center, α-complex-binding portion of the 3'-0TR of an a-globin gene, such as of a human a-globin gene, or a homolog, a fragment, or a variant of an a-globin gene, preferably according to SEQ ID NO: 39701 or SEO ID NO: 39702 (also referred to herein as "muag") (corresponding to SEO ID NO: 1393 of the patent application WO 2013/143700), or a homolog, a fragment, or a variant thereof.

The term "a nucleic acid sequence which is derived from the 3'-0TR of a [...] gene" preferably refers to a nucleic acid sequence which is based on the 3'-UTR sequence of a [...] gene or on a part thereof, such as on the 3'-UTR of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagen alpha gene, such as a collagen alpha 1(1) gene, preferably of an albumin gene or on a part thereof. This term includes sequences corresponding to the eotire 3'-0TR sequence, i.e. the full length 3'-0TR sequence of a gene, and sequences corresponding to a fragment of the 3'-UTR sequence of a gene, such as an albumin gene, α-globin gene, β-globin gene, tyrosine hydroxylase gene, lipoxygenase gene, or collagen alpha gene, such as a collagen alpha 1(1) gene, preferably of an albumin gene.

The term "a nucleic acid sequence which is derived from a variant of the 3'-UTR of a [...] gene" preferably refers to a nucleic acid sequence, which is based on a variant of the 3'-0TR sequence of a gene, such as on a variant of the 3'-UTR of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, or a collagen alpha gene, such as a collagen alpha 1(1) gene, or on a part thereof as described above. This term includes sequences corresponding to the entire sequence of the variant of the 3'-UTR of a gene, i.e. the full length variant 3'-UTR sequence of a gene, and sequences corresponding to a fragment of the variant 3'-0TR sequence of a gene. A fragment in this context preferably consists of a continuous stretch of nucleotides corresponding to a continuous stretch of nucleotides in the full-length variant 3'-UTR, which represents at least 20%, preferably at least 30%, more preferably at least 40%, more preferably at least 50%, even more preferably at least 60%, even more preferably at least 70%, even more preferably at least 80%, and most preferably at least 90% of the full-length variant 3'-0TR. Such a fragment of a variant, in the sense of the present invention, is preferably a functional fragment of a variant as described herein.

Preferably, the at least one 5'-UTR element and the at least one 3'-0TR element act synergistically to increase protein production from the inventive artificial nucleic acid as described above.

Histone-stem-loop:

In a particularly preferred embodiment, the inventive artificial nucleic acid as described herein comprises a histone stem-loop sequence/structure (histone stem-loop). Such histone stem-loop sequences are preferably selected from histone stem-loop sequences as disclosed in W02012/019780, whose disclosure is incorporated herewith by reference. A histnne stem-loop sequence, suitable to be used within the present invention, is preferably selected from at least one of the following formulae (I) or (II): formula (I) (stem-loop sequence without stem bordering elements):

[N0-2GN3-5] [No-4(U/T)No-4] [N3-5CN0-2]

v. _ Y \ _ Y w _ Y /- stem loop stem2 formula (II) (stem-loop sequence with stem bordering elements): N1-6 [N0-2GN3-5] [No-4(U/T)No-4] [N3-5CN0-2] N1-6 steml steml loop stem2 stem2

bordering element bordering element

wherein:

steml or stem2 bordering elements NI-B is a consecutive sequence of I to B, preferably of 2 to 6, more preferably of 2 to 5, even more preferably of 3 to 5, most preferably of 4 to 5 or 5 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C, or a nucleotide analogue thereof: steml [N0-2GN3.5] is reverse complementary or partially reverse complementary with element stem2, and is a consecutive sequence between of 5 to 7 nucleotides; wherein No-z is a consecutive sequence of D to 2, preferably of D to I, mare preferably of I N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof: wherein N3-5 is a consecutive sequence of 3 to 5, preferably of 4 to 5, more preferably of 4 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof, and wherein G is guanosine nr an analogue thereof, and may be optionally replaced by a cytidine or an analogue thereof, provided that its complementary nucleotide cytidine in stem2 is replaced by guanosine; loop sequence [ND-4(U/T)ND-A] is located between elements steml and stem2, and is a consecutive sequence of 3 to

5 nucleotides, more preferably of 4 nucleotides; wherein each No-4 is independent from another a consecutive sequence of D to 4, preferably of I to 3, more preferably of I to 2 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; and

wherein U/T represents uridine, or optionally thymidine; stem2 [N3-5CN0-2] is reverse complementary or partially reverse complementary with element steml, and is a consecutive sequence between of 5 to 7 nucleotides; wherein N3-5 is a consecutive sequence of 3 to 5. preferably of 4 to 5, more preferably of 4 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; wherein No-z is a consecutive sequence of 0 to 2, preferably of D to I, mare preferably of 1 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G or C or a nucleotide analogue thereof; and wherein C is cytidine or an analogue thereof, and may be optionally replaced by a guanosine or an analogue thereof provided that its complementary nucleoside guanosine in steml is replaced by cytidine; wherein

steml and stem2 are capable of base pairing with each other forming a reverse complementary sequence, wherein base pairing may occur between steml and stem2, e.g. by Watson-Crick base pairing of nucleotides A and U/T or G and C or by non-Watson- Crick base pairing e.g. wobble base pairing, reverse Watson-Crick base pairing, Hoogsteen base pairing, reverse Hoogsteen base pairing or are capable of base pairing with each other forming a partially reverse complementary sequence, wherein an incomplete base pairing may occur between steml and stem2. on the basis that one ore more bases in one stem do not have a complementary base in the reverse complementary sequence of the other stem. According to a further preferred embodiment of the first inventive aspect, the inventive artificial nucleic acid may comprise at least one histone stem-loop sequence according to at least one of the following specific formulae (la) or (Ha): formula (la) (stem-loop sequence without stem bordering elements):

[N0-1GN3-5] [Ni- ₃ (U/T)No- ₂ ] [N3-5CN0-1] steml loop stem2

formula (Ha) (stem-loop sequence with stem bordering elements):

steml steml loop stem2 stem2

bordering element bordering element wherein: N, C, G, T and U are as defined above.

According to a further more particularly preferred embodiment of the first aspect, the inventive artificial nucleic acid may comprise at least one histone stem-loop sequence according to at least one of the following specific formulae (lb) or (lib): formula (lb) (stem-loop sequence without stem bordering elements):

[N1GN4] [N ₂ (U/T)Ni] [N4CN1]

Y Y~

steml loop stem2 formula (lib) (stem-loop sequence with stem bordering elements):

N4-5 [N1GN4] [N ₂ (U/T)Ni] [N4CN1] N4-5

Y Y γ Y Y

steml tem1 loop stem2 stem2

bordering element bordering element wherein: N. C, G, T and U are as defined above.

A particular preferred histone stem-loop sequence is the nucleic acid sequence according to SEQ ID NO: 30703, or more preferably the corresponding NA sequence according to SEQ ID NO: 3B7I0. Additional peptide or protein elements:

According to other preferred embodiments, the artificial nucleic acid sequence, particularly the RNA sequence according to the invention may additionally encode further peptide or protein elements that e.g., promote secretion of the protein (secretory signal peptides), promote anchoring of the encoded antigen in the plasma membrane (transmembrane domains), promote virus- like particle formation (VLP forming domains). In addition, the artificial nucleic acid sequence according to the present invention may additionally encode peptide linker elements, self-cleaving peptides or helper peptides.

According to another particularly preferred embodiment, the inventive artificial nucleic acid may additionally or alternatively encode a secretory signal peptide (signal sequence). Such signal peptides are sequences, which typically exhibit a length of about ID to 3D amino acids and are preferably located at the H-terminus of the encoded peptide, without being limited thereto. Signal peptides as defined herein preferably allow the transport of the at least one protein encoded by the at least one coding region of the inventive artificial nucleic acid into a defined cellular compartment, preferably the cell surface, the endoplasmic reticulum (ER) or the endosomal-lysosomal compartment. Examples of secretory signal peptide sequences as defined herein include, without being limited thereto, signal sequences of classical or non-classical MHC-molecules (e.g. signal sequences of HC I and II molecules, e.g. of the MHC class I molecule HLA-A*D2DI), signal sequences of cytokines or immunoglobulines as defined herein, signal sequences of the invariant chain of immunoglobulines or antibodies as defined herein, signal sequences of Lampl, Tapasin, Erp57, Calretikulin, Calnexin, and further membrane associated proteins or of proteins associated with the endoplasmic reticulum (ER) or the endosomal-lysosomal compartiment. More preferably, signal sequences of MHC class I molecule HLA-A*020I may be used according to the present invention.

According to other embodiments, the artificial nucleic acid sequence, particularly the RNA sequence according to the invention may additionally encode at least one transmembrane domain element.

Transmembrane elements or membrane spanning polypeptide elements are present in proteins that are integrated or anchored in plasma membranes of cells. Typical transmembrane elements are alpha-helical transmembrane elements. Such transmembrane elements are composed essentially of amino acids with hydrophobic side chains, because the interior of a cell membrane (lipid bilayer) is also hydrophobic. From the structural perspective, transmembrane elements are commonly single hydrophobic alpha helices or beta barrel structures; whereas hydrophobic alpha helices are usually present in proteins that are present in membrane anchored proteins (e.g., seven transmembrane domain receptors), beta-barrel structures are often present in proteins that generate pores or channels.

For target proteins, such as antigenic peptides or proteins according to the present invention (derived from Norovirus) it may be beneficial to introduce a transmembrane element into the respective constructs. By addition of a transmembrane element to the target peptide/protein it may be possible to further enhance the immune response, wherein the translated target peptide/protein, e.g. a viral antigen, anchors to a target membrane, e.g. the plasma membrane of a cell, thereby increasing immune responses. This effect is also referred to as antigen clustering. When used in combination with a polypeptide or protein of interest in the context of the present invention, such transmembrane element can be placed N-terminal or C-terminal to the Norovirus antigenic peptide or protein of interest. On nucleic acid level, the coding sequence far such transmembrane element is typically placed in frame (i.e. in the same reading frame), 5' or 3' to the coding sequence of the polypeptide as defined herein.

The transmembrane domain may be selected from the transmembrane domain of Hemagglutinin (HA) of Influenza virus, Env of HIV-I, EIAV (equine infectious anaemia virus), MLV (murine leukaemia virus), mouse mammary tumor virus, G protein of VSV (vesicular stomatitis virus). Rabies virus, or a transmembrane element of a seven transmembrane domain receptor.

According to other embodiments, the artificial nucleic acid sequence, particularly the RNA sequence according to the invention may additionally encode at least Dne VLP forming domain.

VLPs are self-assembled viral structural proteins (envelope proteins or capsid proteins) that structurally resemble viruses (without containing viral genetic material). VLPs contain repetitive high density displays of antigens which present conformational epitopes that can elicit strong T cell and B cell immune responses.

When used in combination with a Norovirus antigenic peptide or protein in the context of the present invention, such VLP forming element can be placed N-terminal or C-terminal to the polypeptide nf interest. On nucleic acid level, the coding sequence for such VLP forming element is typically placed in frame (i.e. in the same reading frame), 5' or 3' to the coding sequence of the polypeptide as defined herein.

For nucleic acid (e.g. RNA) encoding a polypeptide or protein of interest, particularly Norovirus antigenic polypeptides or proteins, it may be beneficial to introduce a VLP forming element into the respective constructs. In addition to the "clustering" of epitopes, an improved secretion of the VLP particle may also increase the immunogenicity of the respective antigen.

VLP forming elements fused to an antigen may generate virus like particles containing repetitive high density displays of antigens. Essentially, such VLP farming elements can be chosen from any viral or phage capsid or envelope protein.

According to another embodiment, the artificial nucleic acid sequence, particularly the RNA sequence according to the invention may additionally encode at least one peptide linker element.

In protein constructs composed of several elements (e.g., Norovirus antigenic peptide or protein fused to a transmembrane domain), the protein elements may be separated by peptide linker elements. Such elements may be beneficial because they allow for a proper folding of the individual elements and thereby the proper functionality of each element. Alternatively, the term "spacer" or "peptide spacer" is used herein. When used in the context of the present invention, such linkers or spacers are particularly useful when encoded by a nucleic acid encoding at least two functional protein elements, such as at least one polypeptide or protein of interest (Norovirus antigens) and at least one further protein or polypeptide element (e.g., VLP forming domain, transmembrane domain). In that case, the 5 linker is typically located on the polypeptide chain in between the polypeptide of interest and the at least one further protein element. Dn nucleic acid level, the coding sequence for such linker is typically placed in the reading frame, 5' or 3' to the coding sequence for the polypeptide Dr protein of interest, or placed between coding regions for individual polypeptide domains of a given protein of interest.

ID Peptide linkers are preferably composed of small, non-polar (e.g. Gly) or polar (e.g. Ser or Thr) amino acids. ThB small size of these amino acids provides flexibility, and allows for mobility of the connecting functional domains. The incorporation of Ser or Thr can maintain the stability of the linker in aqueous solutions by farming hydrogen bonds with the water molecules, and therefore reduces an interaction between the linker and the protein moieties. Rigid linkers generally maintain the distance between the protein domains and they may be based on helical structures and/or they have a sequence that is rich in proline.

15 Cleavable linkers (also termed "cleavage linkers") allow for in vivo separation of the protein domains. The mechanism of cleavage may be based e.g. on reduction of disulfide bonds within the linker sequence or proteolytic cleavage. The cleavage may be mediated by an enzyme (enzymatic cleavage), e.g. the cleavage linker may provide a protease sensitive sequence (e.g., furin cleavage). D A typical sequence of a flexible linker is composed of repeats of the amino acids Glycine (G) and Serine (S). For instance, the linker may have the following sequence: GS, GSG, SGG, SG, GGS, SGS, GSS, SSG. In some embodiments, the same sequence is repeated multiple times (e.g. two, three, four, five or six times) to create a longer linker. In other embodiments, a single amino acid residue such as S or G can be used as a linker. 5 Linkers or spacers may be used as additional elements to promote or improve the secretion of the target protein (Norovirus antigenic peptides or proteins).

According to other embodiments, the artificial nucleic acid sequence, particularly the RNA sequence according to the invention may additionally encode at least one self-cleaving peptide.

0

Viral self-cleaving peptides (2A peptides) allow the expression of multiple proteins from a single open reading frame. The terms 2A peptide and 2A element are used interchangeably herein. The mechanism by the 2A sequence for generating two proteins from one transcript is by ribosome skipping - a normal peptide bond is impaired at 2A, resulting in two discontinuous protein fragments from one translation event.

5 When used in the context of the present invention, such 2A peptides are particularly useful when encoded by a nucleic acid encoding at least two functional protein elements (e.g. two Norovirus antigenic peptides or proteins). In general, a 2A element is useful when the nucleic acid molecule encodes at least one polypeptide or protein of interest and at least one further protein element. In a preferred embodiment, a 2A element is present when the polynucleotide of the invention encodes two proteins or 5 polypeptides of interest, e.g. two antigens.

The coding sequence for such 2A peptide is typically located in between the coding sequence of the polypeptide of interest and the coding sequence of the least one further protein element (which may also be a polypeptide of interest), so that cleavage of the 2A peptide leads to two separate polypeptide molecules, at least one of them being a polypeptide or protein of interest.

ID

For example, for expressing target proteins (Norovirus antigenic peptides or proteins) that are composed of several polypeptide chains it may be beneficial to provide coding information for both polypeptide chains on a single nucleic acid molecule, separated by a nucleic acid sequence encoding a 2A peptide. 2A peptides may also be beneficial when cleavage of the protein of interest from another encoded polypeptide element is desired.

15

2A peptides may be derived from foot-and-mouth diseases virus, from equine rhinitis A virus, Thosea asigna virus, Porcine teschovirus-l.

According to Dther embodiments, the artificial nucleic acid sequence, particularly the NA sequence according to the inventionD may additionally encode at least one helper peptide.

In essence, helper peptides binds to class II MHC molecules as a nonspecific vaccine helper epitope (adjuvant) and induces an increased (and long term) immune response by increasing the helper T-cell response. In an embodiment, such a helper peptide may be N-terminally and/or C-terminally fused to the antigenic peptide or protein derived from Norovirus.

5

m NA structures:

Any of the above modifications may be applied to the artificial nucleic acid of the present invention, and further to any nucleic acid as used in the context of the present invention and may be, if suitable or necessary, be combined with each other in any combination, provided, these combinations of modifications do not interfere with each other in the artificial nucleic acid. A personD skilled in the art will be able to take his choice accordingly.

The artificial nucleic acid as defined herein, may preferably comprise a 5'-UTR, a coding region encoding the at least one polypeptide comprising at least one Norovirus protein as described herein, or a fragment, variant or derivative thereof; and/or a 3'-UTR preferably containing at least one histone stem-loop. The 3'-UTR of the artificial nucleic acid preferably comprises also5 a poly(A) and/or a poly(C) sequence as defined herewithin. The single elements of the 3'-UTR may occur therein in any order from 5' to 3' along the sequence of the artificial nucleic acid. In addition, further elements as described herein, may also be contained, such as a stabilizing sequence as defined herewitbin (e.g. derived from the UTR of a globin gene), IRES sequences, etc. Each of the elements may also be repeated in the artificial nucleic acid according to the invention at least once (particularly in di- or multicistronic constructs), preferably twice or more. As an example, the single elements may be present in the artificial nucleic acid in the following order:

5' - coding region - histone stem-loop - poly(A)/(C) sequence - 3'; or

5' - coding region - poly(A)/(C) sequence - histone stem-loop - 3'; or

5' - coding region - histone stem-loop - polyadenylation signal - 3'; or

5' - coding region - polyadenylation signal- histone stem-loop - 3'; or

5' - coding region - histone stem-loop - histone stem-loop - poly(A)/(C) sequence - 3'; or

5' - coding region - histone stem-loop - histone stem-loop - polyadenylation signal- 3'; or

5' - coding region - stabilizing sequence - poly(A)/(C) sequence - histone stem-loop - 3'; or

5' - coding region - stabilizing sequence - poly(A)/(C) sequence - poly(A)/ (C) sequence - histone stem-loop - 3'; etc.

In this context, it is particularly preferred that - if, in addition to the at least one encoded polypeptide defined herein, a further peptide or protein is encoded by the artificial nucleic acid - the encoded peptide Dr protein is preferably no histone protein, no reporter protein (e.g. Luciferase, GFP, EGFP, β-Galactosidase, particularly EGFP) and/or no marker or selection protein (e.g. alpha-Globin, Galactokinase and Xanthine:Guanine phosphoribosyl transferase (GPT)). In a preferred embodiment, the artificial nucleic acid according to the invention does not comprise a reporter gene or a marker gene. Preferably, the artificial nucleic acid according to the invention does not encode, for instance, luciferase; green fluorescent protein (GFP) and its variants (such as eGFP, RFP or FJFP); ot-globin; hypoxanthine-guanine phosphoribosyltransferase (HGPRT); β-galactosidase; galactokinase; alkaline phosphatase; secreted embryonic alkaline phosphatase (SEAP)) or a resistance gene (such as a resistance gene against neomycin, puromycin, hygramycin and zeocin). In a preferred embodiment, the artificial nucleic acid according to the invention does not encode luciferase. In another embodiment, the artificial nucleic acid according to the invention does not encode GFP or a variant thereof.

According to a preferred embodiment, the inventive artificial nucleic acid comprises or consists of, preferably in 5' to 3' direction, the following elements:

a) optionally, a 5'-cap structure (capD, capl, cap2), preferably m7GpppN,

b) a coding region encoding at least one protein comprising at least one Norovirus protein as described herein, or a fragment or variant thereof,

c) optionally a poly(A) tail, preferably consisting of 10 to 20D, ID to IOD, 4D to 8D or 50 to 70 adenosine nucleotides, d) optionally a poly(C) tail, preferably consisting of 10 to 200, 10 to IOD, 20 to 70, 20 to B0 or 10 to 40 cytosine nucleotides, and

e) optionally a histone stem-loop, preferably comprising the RNA sequence according to SEQ ID NO: 33700 to SEfl ID NO:

30710. More preferably, the artificial nucleic acid according to the invention comprises or consists of, preferably in 5' to 3' direction, the following elements:

a) optionally, a 5'-cap structure (capD, capl, cap2), preferably m7GpppN,

b) a coding region encoding at least one protein comprising at least one Norovirus protein as described herein, or a fragment or variant thereof,

c) a 3'-UTR element comprising a nucleic acid sequence, which is derived from an a-globin gene, preferably comprising the corresponding RNA sequence of the nucleic acid sequence according to SEQ ID NO: 39701, or SEQ ID NO: 39702, or a homolog, a fragment or a variant thereof,

d) optionally a poly(A) tail, preferably consisting of 10 to 200, 10 to 100, 0 to 80 or 50 to 70 adenosine nucleotides, e) optionally a poly(C) tail, preferably consisting of 10 to 200, 10 to 100, 20 to 70, 20 to B0 or 10 to 40 cytosine nucleotides, and

f) optionally a histone stem-loop, preferably comprising the RNA sequence according to SEO 10 NO: 3970B to SEQ ID NO:

397IQ.

According to a particularly preferred embodiment the RNA sequence according to the invention comprises, preferably in 5'- to 3'-direction:

a) a 5'-cap structure (capO, capl. cap2), preferably m7GpppN;

b) a 5'-0TR element which comprises or consists of a nucleic acid sequence corresponding to a nucleic acid sequence according to SEQ ID NO: 39691, or SEQ ID NO: 39G92, or SEQ ID NO: 39G93, or SEQ ID NO: 39694. a homolog, a fragment or a variant thereof:

c) at least one coding sequence according to any one of SEQ ID NOs: 8821-39690, 39717, and/or 39730 or a variant or fragment thereof encoding at least one antigenic peptide or protein derived from a Norovirus protein or peptide or a fragment or variant thereof according to any one of SEQ ID NOs: 1-4410, preferably comprising or consisting of any one of the nucleic acid sequences according to, or a fragment or variant thereof,

d) a 3'-UTR element comprising or consisting of a nucleic acid sequence which is derived from a gene providing a stable RNA, preferably comprising or consisting of the corresponding to a nucleic acid sequence according to SEQ ID NO: 39707, or SEQ ID NO: 39708, or SEQ ID NO: 39703, or SEQ ID NO: 39704, a homolog, a fragment or a variant thereof: e) optionally, a poly(A) sequence preferably comprising 64 adenosines; and

f) optionally, a poly(C) sequence, preferably comprising 30 cytosines.

More preferably, the artificial nucleic acid according to the invention comprises or consists of, preferably in 5' to 3' direction, the following elements:

a) optionally, a 5'-cap structure (capO, capl, cap2), preferably m7GpppN, b) a 5'-QTR element, which comprises or consists of a nucleic acid sequence, which is derived from the 5'-UTR of a TOP gene, preferably comprising a nucleic acid sequence according to SEQ ID NO: 39691 to SED ID NO: 39694, or a homolog, a fragment Dr a variant thereof,

c) a coding sequence encoding at least one protein comprising at least one Norovirus protein as described herein, or a fragment or variant thereof,

d) a 3'-DTR element comprising a nucleic acid sequencE, which is derived from an albumin gene, preferably comprising the corresponding RNA sequence of the nucleic acid SEquence according to SEO ID NO: 33705, or SEQ ID NO: 3B7DB, or a homolog, a fragment or a variant thereof,

e) optionally a poly(A) tail, preferably consisting of 10 to 20D, 10 to 100, 0 to 80 or 5D to 70 adenosine nucleotides, f) optionally a poly(C) tail, preferably consisting of 10 to 2D0, ID to IDO, 20 to 70, 2D to B0 or ID to 4D cytosine nucleotides, and

g) optionally a histone stem-loop, preferably comprising the RNA sequence according to SEQ ID NO: 39700 to SEQ ID NO:

39710.

In some embodiments, the at least one coding region of the artificial nucleic acid according to the present invention comprises a nucleic acid sequence encoding a molecular tag. More preferably, the molecular tag is selected from the group consisting of a FLAG tag, a glutathionE-S-transferase (GST) tag, a His tag, a Myc tag, an E tag, a Strep tag, a green fluorescent protein (GFP) tag and an HA tag.

In particularly preferred Embodiments the mRNA sequBnce according to the invention comprises the following mRNA sequences (or RNA sequences being identical or at least 50%, 60%, 7096. 80%.85%, 86%. 87%, 88%, 8B%, 90%, 91%, 92%, 93%, 94%, 95%, 36%. 97%, 98%, or 99% identical to the following RNA sequences):

- mRNA encoding VPI protein of Norovirus GII.4-03IG93-USA-2003; SEQ ID NO: 39713.

- mRNA encoding VPI protein of Norovirus GII.4-03I693-USA-2003; SEQ ID NO: 30714.

- mRNA encoding VPI protein of Norovirus GII.4-03I693-0SA-2D03: SEQ ID NO: 39715.

- mRNA encoding VPI protein of Norovirus GII.4-03I693-USA-2DD3: SEO ID NO: 397IG.

- mRNA encoding VPI protein of Norovirus GII.4-D3I693-0SA-20D3: SEO ID NO: 39717.

- mRNA encoding VPI protein of Norovirus GII.4 Farmington Hills-2002-DSA; SEQ ID NO: 39718.

- mRNA encoding VPI protein of Norovirus GII.4 Farmington Hills-2002-0SA: SEQ ID NO: 39719.

- mRNA encoding VPI protein of Norovirus GII.4 Farmington Hills-20D2-USA: SEQ ID NO: 39720.

- mRNA encoding VPI protein of Norovirus GII.4 Farmington Hills-20D2-USA; SEQ ID NO: 39721.

mRNA encoding VPI protein of Norovirus Gl.l- JSA-1968 : SEQ ID NO 30722.

mRNA encoding VPI protein of Norovirus Gl.l- JSA-I9B8 ; SEQ ID NO 39723.

mRNA encoding VPI protein of Norovirus Gl.l- JSA-I9B8 : SEQ ID NO 39724.

mRNA encoding VPI protein of Norovirus Gl.l- JSA-I9B8 : SEQ ID ND 39725.

mRNA encoding VPI protein of Norovirus GII.42006b 092835-0SA-2D08; SEQ ID NO: 39726. - mRNA encoding VPI protein of Norovirus GII.4 ZDDBb 092895-USA-2008; SEQ ID ND: 39727.

- mRNA encoding VPI protein of Norovirus GII.42006b D92895-USA-2D08; SEQ ID ND: 39728.

- mRNA encoding VPI protein of Norovirus GII.42006b 092895-DSA-2008; SE0 ID ND: 39729.

- mRNA encoding VPI protein of Norovirus GII.42006b D92895-USA-2008: SED ID ND: 39730.

5 - mRNA encoding VPI protein of Norovirus GII.4 GZ2DID-L87-Guangzhou-2DII; SED ID ND: 3973I.

- mRNA encoding VPI protein of Norovirus GII.4 GZ2DI0-L87-Guangzhou-2DII; SED ID ND: 39732.

- mRNA encoding VPI protein of Norovirus GII.4 GZ20IO-L87-Guangzhou-20ll; SED ID ND: 39733.

- mRNA encoding VPI protein of Norovirus GII.4 GZ2DI0-L87-Guangzhou-2DII; SEQ ID ND: 39734.

- mRNA encoding VPI protein of Norovirus GII.4 DSA-I997: SEQ ID ND: 39735.

ID - mRNA encoding VPI protein of Norovirus GII.4 USA-I997: SED ID ND: 39736.

- mRNA encoding VPI protein of Norovirus GII.4 USA-I997: SED ID ND: 39737.

- mRNA encoding VPI protein of Norovirus GII.4 DSA-I997; SEQ ID ND: 39738.

mRNA encoding VPI protein of Norovirus Melksham; SEQ ID ND 39739.

mRNA encoding VPI protein of Norovirus Melksham; SEQ ID ND 3974D.

I5 mRNA encoding VPI protein of Norovirus Melksham: SED ID ND 3974I.

mRNA encoding VPI protein of Norovirus Melksham; SED ID ND 39742.

- mRNA encoding VPI protein of Norovirus GII.2-Vaals87-2DD5-NL; SEQ ID NO 39743.

mRNA encoding VPI protein of Norovirus GII.2-Vaals87-2005 L; SEQ ID ND 39744.

- mRNA encoding VPI protein of Norovirus GII.2-Vaals87-2005 L; SED ID NO 39745.

0 mRNA encoding VPI protein of Norovirus GII.2-Vaals87-2005 L; SED ID ND 39746.

RNA production:

The artificial nucleic acid according to the invention may be prepared by using any suitable method known in the art, including synthetic methods such as e.g. solid phase synthesis, as well as recombinant and in vitro methods, such as in vitro transcription5 reactions.

In a preferred embodiment, a linear DNA template is transcribed in vitro using DNA dependent T7 RNA polymerase in the presence of a nucleotide mixture and cap analog (m7GpppG) under suitable buffer conditions. In a particularly preferred embodiment, RNA production is performed under current good manufacturing practice, implementing various quality control steps, e.g. accordingD to W0 2DI6/I80430. The obtained RNAs are HPLC purified using PureMessenger ⁰ (CureVac, Tubingen, Germany; W0 2D08/D77592). In a preferred embodiment, purified RNA product is lyophilized according to WD 2DI6/I6583I to yield a temperature stable Norovirus artificial nucleic acid. For the production of polyvalent Norovirus compositions, methods as disclosed in the PCT application PCT/EP20I6/Q82487 are preferably used and adapted accordingly. Composition:

In a further aspect, the present invention provides a composition comprising at least one artificial nucleic acid as described herein and a suitable carrier, preferably a pharmaceutically acceptable carrier. The inventive composition comprising the artificial nucleic acid as described herein is preferably a (pharmaceutical) composition or a vaccine as described herein.

5

The inventive composition may comprise either only one type of artificial nucleic acid or at least two different artificial nucleic acids. In particular, the inventive composition may comprise at least two artificial nucleic acids as described herein, wherein each of the at least two artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising a different one of the Norovirus proteins as described herein, or a fragment or a variant of any one of these proteins.

ID Alternatively, the composition may comprise at least two artificial nucleic acids as described herein, wherein each of the at least two artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising at least two different Norovirus proteins as described herein, or a fragment or a variant Df any one of these proteins. In another embodiment, the composition may also comprise at least two different artificial nucleic acids, which are bi- or multicistronic nucleic acids as described herein and wherein each of the artificial nucleic acids encodes at least two polypeptides, each comprising at least one

15 Norovirus protein, or a fragment or variant thereof.

Preferably, the inventive composition comprises or consists of at least one artificial nucleic acid as described herein and a pharmaceutically acceptable carrier. The expression "pharmaceutically acceptable carrier" as used herein preferably includes the liquid or non-liquid basis of the inventive composition, which is preferably a pharmaceutical composition or a vaccine. If theD inventive composition is provided in liquid form, the carrier will preferably be water, typically pyrogeo-free water; isotonic saline or buffered (aqueous) solutioos, e.g phosphate, citrate etc. buffered solutions. Water or preferably a buffer, more preferably an aqueous buffer, may be used, containing a sodium salt, preferably at least 5D mM of a sodium salt, a calcium salt, preferably at least 0,01 mM of a calcium salt, and optionally a potassium salt, preferably at least 3 mM of a potassium salt. According to a preferred embodiment, the sodium, calcium and, optionally, potassium salts may occur in the form of their halogenides, e.g.5 chlorides, iodides, or bromides, in the form of their hydroxides, carbonates, hydrogen carbonates, or sulfates, etc. Without being limited thereto, examples of sodium salts include e.g. NaCI, Nal, NaBr, NazC03, NaHC03, NazSOs, examples of the optional potassium salts include e.g. KCI, Kl, KBr, K2CO3, KHCO3, 2SO4, and examples of calcium salts include e.g. CaClz. Cab, CaBr2, CaCOs, CaSOi, Ca(DH)z. Furthermore, organic anions of the aforementioned cations may be contained in the boffer. 0 Furthermore, one or more compatible solid or liquid fillers or diluents or encapsulating compounds may be used as well, which are suitable for administration to a person. The term "compatible" as used herein means that the constituents of the inventive composition are capable of being mixed with the at least one artificial nucleic acid of the composition, in such a manner that no interaction occors, which would substantially reduce the biological activity or the pharmaceutical effectiveness of the inventive composition under typical use conditions. Pharmaceutically acceptable carriers, fillers and diluents must, of course, have5 sufficiently high purity and sufficiently low toxicity to make them suitable for administration to a person to be treated. Some examples of compounds which can be used as pharmaceutically acceptable carriers, fillers or constituents thereof are sugars, such as, for example, lactose, glucose, trehalose and sucrose; starches, such as, for example, corn starch or potato starch; dextrose; cellulose and its derivatives, such as, for example, sodium carboxymethylcellulose, ethylcellulose, cellulose acetate; powdered tragacanth; malt; gelatin; tallow; solid gliddants, such as, for example, stearic acid, magnesium stearate; calcium sulfate; vegetable oils, such as, for example, groundnut oil, cottonseed oil, sesame oil, olive oil, corn oil and oil from theobroma; 5 polyols, such as, for example, polypropylene glycol, glycerol, sorbitol, mannitol and polyethylene glycol; alginic acid.

Further additives which may be included in the inventive composition are emulsifiers, such as, for example, Tween; wetting agents, such as, far example, sodium lauryl sulfate; colouring agents; taste-imparting agents, pharmaceutical carriers; tablet-forming agents; stabilizers; antioxidants; preservatives.

ID

In another embodiment, the composition of the invention comprises at least 2, 3, 4, 5, 6, 7, 8, 3, ID, II, 12, 13, 14. 15, IB, 17, 18, 13, 20, 1, 22.23, 24, 25, 2B, 27, 28, 23, 30, 31. 32, 33, 34, 35, 3B, 37, 38, 33, 40, 41, 42, 3, 44, 45, B, 47, 48, 43, 50, 51, 52, 53, 54, 55, 5B, 57, 58, 53, GO, Gl, G2, 63, G4, 65, 66, 67. 68.63.70.71.72, 73.74, 75, 76, 77, 78, 73, 80, 81, 82, 83, 84, 85, 86, 87, 88, 83, 30, 31, 32, 33, 34, 95, 36, 37, 38, 39, 100 or more artificial nucleic acids of the invention, wherein each of the at least 2, 3, 4, 5,

15 B, 7, 8. 3. 10, II. 12. 13, 14, 15, 16, 17, 18, 19.20, 21, 22, 23, 24, 25, 26, 27. 28, 29, 30. 31. 32, 33. 34, 35, 3B. 37. 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 8, 43, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, B2, B3, 64, 65, B6, 67, B8, 63. 70, 71, 72, 73, 74, 75, 76, 77, 78, 73, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 30, 31, 32, 93, 34, 95, 96, 97, 98, 99, 10D or more artificial nucleic acids of the invention comprises at least one coding region encoding at least one polypeptide comprising a Norovirus protein, and/ or a fragment or a variant of any one of these proteins, wherein each coding region preferably encodes a different Norovirus protein, more0 preferably each coding region encodes a capsid protein, preferably VPI of a different Norovirus.

In another embodiment, the composition of the invention comprises at least 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25,26, 7, 28, 29.30, 31.32. 33, 34, 35, 36, 37, 38, 39, 40, 41, 42.43.44, 45, 46, 47, 48, 49, 5051, 52, 53.54, 55, 56, 57, 58, 59, B0, 61, 62.63, 64, 65, B6, B7, 68, B9, 70.71, 72, 73, 74, 75, 76, 77, 78.79, 8D. 81, 82, 83, 84, 85, 86, 87, 88, 89, 30,5 31, 32, 33, 34, 35, 96, 97, 98, 99, 100 or more artificial nucleic acids of the invention, wherein each of the at least 2, 3, , 5, B, 7, 8. 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 5, 26, 27, 28, 29. 30. 31. 32. 33. 34. 35. 3B. 37, 38, 39, 40, 41, 42, 43, 44. 45, 46. 7. 48, 49, 5051, 52, 53, 54, 55, 5B, 57, 58, 59, 60, 61, 62. 63, 64, B5, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 7B, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more artificial nucleic acids of the invention comprises at least one coding region encoding at least one polypeptide comprising at least two different Norovirus proteins.0 preferably VPI and VP2, and/ or a fragment or a variant of any one of these proteins.

In a preferred embodiment, the inventive composition, which is preferably a pharmaceutical composition or a vaccine, comprises at least one artificial nucleic acid as described herein, wherein the at least one artificial nucleic acid is complexed at least partially with a cationic Dr polycationic compound and/or a polymeric carrier, preferably a cationic protein or peptide.5 Accordingly, in a further embodiment of the invention it is preferred that the at least one artificial nucleic acid as defined herein or any other nucleic acid comprised in the inventive (pharmaceutical) composition or vaccine is associated with or complexed with a cationic or polycationic compound or a polymeric carrier, optionally in a weight ratio selected from a range of about 6:1 (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/ w) to about 0.5:1 (w/ w), even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w) of the artificial nucleic acid or any other nucleic acid to cationic or polycationic compound and/or with a polymeric carrier; or optionally in a nitrogen/phosphate (N/P) ratio of the artificial nucleic acid or any other nucleic acid to cationic or polycationic compound and/or polymeric carrier in the range of about 0.1-10, preferably in a range of about 0.3-4 or 0.3-1, and most preferably in a range of about 0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-0.9 or 0.5-0.9. More preferably, the N/P ratio of the at least one artificial nucleic acid to the one or mure polycations is in the range of about 0.1 to 10, including a range of about 0.3 to 4, of about 0.5 to 2, of about 0.7 to 2 aod of about 0.7 to 1.5.

In another embodiment, the composition comprising at least one artificial nucleic acid of the invention is defined as follows: (i) the ratio of complexed nucleic acid to free nucleic acid is selected from a range of about 5:1 (w/w) to about 1:10 (w/w), more preferably from a range of about 4:1 (w/w) to about 1:8 (w/w), even more preferably from a range of about 3:1 (w/w) to about 1:5 (w/w) or 1:3 (w/w), wherein the ratio is most preferably about 1:1 (w/w); or

(ii) the mRNA is complexed with one or more cationic or polycationic compounds in a weight ratio selected from a range of about B:l (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w:w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w) of mRNA to cationic or polycationic compound and/or with a polymeric carrier; or optionally in a nitrogen/phosphate ratio of mRNA to cationic or polycationic compound and/or polymeric carrier in the range of about 0.1-10. preferably in a range of about 0.3-4 or 0.3-1, and most preferably in a range of about 0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-O.B or 0.5-0.9;

and/or wherein the at least one artificial nucleic acid or mRNA is complexed with one or more cationic or polycationic compounds, preferably with cationic or polycationic polymers, cationic or polycationic peptides or proteins, e.g. protamine, cationic or polycationic polysaccharides and/or cationic or polycationic lipids and/or wherein the at least one artificial nucleic acid or mRNA is complexed with one or more lipids and thereby forming liposomes, lipid nanoparticles and/or lipoplexes.

Preferably, the inventive composition comprises at least one artificial nucleic acid as described herein, which is complexed with one or more polycations and/or a polymeric carrier, and at least one free nucleic acid, wherein the at least one complexed nucleic acid is preferably identical to the at least one artificial nucleic acid according to the present invention. In this context it is particularly preferred that the at least one artificial nucleic acid of the inventive composition is complexed at least partially with a cationic or polycationic compound and/or a polymeric carrier, preferably cationic proteins or peptides. In this context, the disclosure of W02010/037539 and W02012/113513 is incorporated herewith by reference. Partially means that only a part of the inventive artificial nucleic acid is complexed with a cationic compound and that the rest of the inventive artificial nucleic acid is (comprised in the inventive pharmaceutical composition or vaccine) in uncnmplexed form ("free"). In a further embodiment, the composition of the invention comprises

(i) at least 2, 3, 4, 5, G, 7, 8, 9, ID or more artificial nucleic acids as defined in the invention: or

(ii) at least ID, 15, 2D nr 50 artificial nucleic acids as defined in the invention; or

(iii) 2-10, 10-15, 15-20, 20-50, 50-100 or 100-200 artificial nucleic acids as defined in the invention;

and a pharmaceutically acceptable carrier.

In one embodiment, the compositions and/or vaccines of the invention comprise artificial nucleic acids encoding one or more capsid proteins VPI derived from one or more Noroviruses. In another embodiment, the compositions and/or vaccines of the invention comprise artificial nucleic acids encoding one or more capsid proteins VP2 derived from one or more Noroviruses.

In another embodiment, the composition of the invention is further defined as composition, wherein

(i) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, , 5, G, 7, 8, 9, 10, II, 12.13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2G, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, G, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, G4, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80. 81, 82, 83, 84, 85, 86, 87, 88, 89, 90.91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different Gl Noroviruses; or

(ii) the artificial nucleic acids are derived from a single Gil Norovirus or from 2, 3.4, 5, 6, 7. 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 3, 4, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 6, 47, 48, 49, 50, 51, 52, 53, 54, 55. 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69.70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86.87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different Gil Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gill Norovirus or from 2, 3, , 5, 6.7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23.24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 2, 43, 44, 45, 4B, 47, 8, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, G6, B7, 68, 69, 70.71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, SB. 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 10D or more different Gill Noroviruses; or

(iv) the artificial nucleic acids are derived from a single GIV Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14. 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 3D. 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41, 42, 43, 44. 45, 6, 7, 48, 9, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, Gl, 62. 63, 64, 65, 66, 67, 68, 69, 7D, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, ID0 or more different GIV Noroviruses; or

(v) the artificial nucleic acids are derived from a single GV Norovirus or from 2, 3, 4, 5, G, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 4, 25, 26, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 42. 43. 44, 45, 6, 47, 8, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85. 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 10D or more different GV Noroviruses; or

(vi) the artificial nucleic acids are derived from a single Gl Norovirus and additionally from a single Gil Norovirus, Gill Norovirus, GIV Norovirus and/or GV Norovirus; or

(vii) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 4, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, G, 47. 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, B5, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 7, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 80, 80, 31, 32.33, 94, 95, 9B, 37, 38, 33, 100 or mare different Gl Noroviruses and additionally from a single Gil, Gill, GIV or GV Norovirus and/or from 2, 3, 4, 5, G, 7. 8, 9, 10, II, 12, 13, 14. 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 30, 40, 41, 2, 43, 44, 45, 46, 47, 8, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68. 69.70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86. 87, 88, 89, 90, 91, 92, 93, 94, 95, 36, 97, 98, 99, 100 and/or more Gil. Gill, GIV or GV Noroviruses.

In a further embodiment, the composition of the invention further is defined as composition, wherein

(i) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, , 5, 6, 7, 8, 9, ID, II, 12, 13, 14, 15, 16, 17, 18, 19, 2D, 21, 22, 23, 24, 25, 26. 27, 28, 29, 3D, 31. 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 2, 43, 44, 45, 6, 47, 48, 49, 50. 51, 52, 53, 54, 55, 56, 57. 58, 59, 60, 61, 62, 63, 64, 65, 66. 67, 68, 69, 7D, 71, 72, 73, 74, 75, 76, 77, 78, 79, 8D, 81,

82, 83, 84, 85, 86, 87, 88, 88, 00, 01, 02, 03, 04, 95, 06.07, 08, 00, 10D or more different Gl.l Noroviruses; or

(ii) the artificial nucleic acids are derived from a single GII.4 Norovirus or from 2, 3, , 5, 6, 7, 8, 8, ID, II, 12, 13, 14, 15, 16, 17, 18, 19, 2D, 21, 22, 23, 24, 25, 26, 27, 28.20, 30.31.32, 33, 34, 35, 36, 37, 38, 30, 40, 41, 42, 43.44, 45, 46.47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 50, 60, 61, 62, 63, 64, 65, 66, 67, 68, 60, 70, 71, 72. 73.74, 75, 76, 77, 78, 70. 80, 81, 82, 83, 84, 85, 86, 87, 88, 80.90. 91, 02, 03, 04, 95, 06, 07, 08, 09, 100 or more different GII.4 Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gl.l Norovirus and additionally from a single GII.4 Norovirus; or

(iv) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, 4, 5, 6, 7, 8, 0, 10, II, 12, 13, 14, 15, 16, 17, 18, 10, 20, 21, 22, 23, 24, 25, 26. 27, 28, 20, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 6, 47, 48, 49. 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84. 85. 86, 87, 88, 80, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different Gl.l Noroviruses and additionally from a single GII.4 Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10. II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 5D, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61. 62. 63, 64. 65, 66, 67, 68, 60, 70, 71, 72, 73, 74, 75, 76, 77, 78, 70, 80, 81, 82, 83, 84, 85, 86, 87, 88, 80, 00, 91, 02, 03, 04, 05, 06. 07, 08, 00, 10D or more GII.4 Noroviruses.

In a further embodiment, the composition of the invention further is defined as composition, wherein

(i) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, 4, 5, 6, 7, 8, 0, ID, II, 12, 13, 14, 15, 16, 17, 18, 19, 2D, 21, 22, 23, 24, 25, 26, 27, 28, 20, 30, 31, 32. 33, 34, 35, 36, 37, 38, 30, 0, 41, 42, 43, 44, 45, 46, 47, 8, 49, 5D. 51, 52, 53, 54, 55, 56. 57. 58, 58, 60, 61, 62, 63, 64, 65, 66, 67, 68, 60, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89.90, 91, 92, 93, 94, 95, 96, 97, 98, 90, 100 or more different Gl.l Noroviruses; or

(ii) the artificial nucleic acids are derived from a single GII.4 Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, ID, II, 12, 13, 14, 15. 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 3, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different GII.4 Noroviruses; or (iii) the artificial nucleic acids are derived from a single Gl.l Norovirus and additionally from a single GII.4 Norovirus; or (iv) the artificial nucleic acids are derived from a single Gl.l Nornvirus or from 2, 3, 4, 5, G, 7, 8, 0, ID. II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2G, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3G, 37, 38, 39, 40, 41, 42, 43, 44, 45, 4G, 47, 48, 49, 5D. 51, 52, 53, 54, 55, 5G, 57, 58, 59, GO, Gl, 62, 63, 64, 65, 66, 67, 68, 69, 70. 71.72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98. 99, 100 or more different Gl.l Noroviruses and additionally from a single GII.4 Norovirus or from 2. 3. , 5, 6.7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27. 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50. 51, 52, 53, 54, 55, 56, 57, 58. 59, 60, 61, 62, 63, 64, 65, 66. 67, 68, 69, 70, 71.72.73.74, 75, 76, 77, 78, 79, 8D, 81. 82, 83, 84, 85, 86, 87, 88, 89, 9D, 91, 92, 93, 94, 95, 96, 97, 98, 99, 10D or more GII.4 Nornviruses; and/or

wherein

(i) at least one of the nucleic acid sequences according to any one of SEQ ID NOs: 4411-39690, 39713-39746; and/ or

(ii) at least one of the nucleic acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 7096. 71%. 72%.73%. 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%. 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to the nucleic acid sequence represented by any one of SEO ID NOs: 4411-39690, 39713-39746; and/or

(iii) at least one complement of the nucleic acid sequences which are capable of hybridizing with a nucleic acid sequence comprising a sequence as shown in SED 10 NOs: 4411-39690, 39713-39746, and/or

(iv) an orthologue or a paralogue of any one of SEO ID NOs: 4411-39690, 39713-39746; and/ or a fragment or variant of any of these sequences.

and/or

wherein

(i) at least one nf the nucleic acid sequences according to any one of SEQ ID ND: 39713 to SEO ID NO: 39746; and/ or

(ii) at least one of the nucleic acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 56%. 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%. 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%. 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to the nucleic acid sequence represented by any one of SEO ID NO: 39713 to SED ID NO: 39746; and/or

(iii) at least one complement of the nucleic acid sequences which are capable of hybridizing with a nucleic acid sequence comprising a sequence as shown in SEO ID NO: 39713 to SEO ID NO: 39746; and/or

(iv) an orthologue or a paralogue of any one of SED ID ND: 39713 to SED ID NO: 39746; and/or a fragment or variant of any of these sequences.

In a preferred embodiment, the composition of the invention further is defined as a composition comprising two different nucleic acid sequences (bivalent, divalent composition), wherein one of the two different nucleic acid sequences is derived from Norovirus GII.4 and one of the two different nucleic acid sequence is derived from Norovirus Gl.l, wherein the one nucleic acid sequence of Norovirus GII.4 may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences, and wherein the one nucleic acid sequence of Noravirus Gl.l may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences. Preferably, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of one nucleic acid sequence derived from Nurovirus GII.4 selected from SED ID NDs: 39713-39721, 39726-39742, and one nucleic acid sequence derived from Noravirus Gl.l 5 selected from SED ID NDs: 39722-39725.

In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 397IG (Norovirus GII.4) and SEQ ID NO: 39725 (Norovirus Gl.l). In a further specific preferred embodiment, the composition comprising two different nucleic acid sequences

ID (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 33721 (Norovirus GII.4) and SED ID ND: 39725 (Norovirus Gl.l). In a further specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 39729 (Norovirus GII.4) and SED ID ND: 39725 (Norovirus Gl.l). In a further specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEQ ID ND: 39734

15 (Norovirus GII.4) and SED ID ND: 39725 (Norovirus Gl.l). In a further specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 39738 (Norovirus GII.4) and SED ID ND: 39725 (Norovirus Gl.l).

In a preferred embodiment, the composition of the invention further is defined as a composition comprising two different nocleicD acid sequences (bivalent, divalent composition) derived from Norovirus GII.4, wherein the two different nucleic acid sequences of Norovirus GII.4 may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences. Preferably, the composition comprising two different nucleic acid sequences derived from Norovirus GII.4 (bivalent, divalent composition) comprises or consists of one nucleic acid sequence selected from SED ID NDs: 39713-39721, 39726-39742. 5 In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 39716 (Norovirus GII.4) and SEQ ID ND: 39721 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEQ ID ND: 39729 (Norovirus GII.4) and SEQ ID ND: 39721 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequencesD (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID NO: 39734 (Norovirus GII.4) and SED ID ND: 39721 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID ND: 39738 (Norovirus GII.4) and SED ID ND: 39721 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEQ ID ND: 397165 (Norovirus GII.4) and SED ID NO: 39729 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid seqoences SEQ ID ND: 39734 (Norovirus GII.4) and SEQ ID NO: 39729 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEfl ID NO: 38738 (Norovirus GII.4) and SEO ID NO: 39729 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEO 10 NO: 397IG (Norovirus GII.4) and SEQ ID NO: 39734 (Norovirus Gll.4).ln a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SED ID NO: 39738 (Norovirus GII.4) and SEfl ID NO: 39734 (Norovirus GII.4). In a specific preferred embodiment, the composition comprising two different nucleic acid sequences (bivalent, divalent composition) comprises or consists of the nucleic acid sequences SEfl ID NO: 397IG (Norovirus GII.4) and SEfl ID NO: 39738 (Norovirus GII.4).

In further a preferred embodiment, the composition of the invention further is defined as a composition comprising four different nucleic acid sequences (tetravalent composition), wherein each of the four different nucleic acid sequences is derived from Norovirus GII.4, wherein each of the four different nucleic of Norovirus GII.4 may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences. Preferably, the composition comprising four different nucleic acid sequences (tetravalent composition) comprises or consists of four nucleic acid sequence derived from Norovirus GII.4 selected from SEfl ID NOs: 39713-39721, 3972G-39742.

In a specific preferred embodiment, the composition comprising four different nucleic acid sequences (tetravalent composition) comprises four of the nucleic acid sequences selected from SEQ ID NOs: 39716, 39721, 39729, 39734 or 39738.

In a further preferred embodiment, the composition of the invention is defined as a composition comprising four different nucleic acid sequences (tetravalent composition), wherein at least one of the four different nucleic acid sequences is derived from Norovirus GII.4 and at least one of the four different nucleic acid sequence is derived from Norovirus Gl.l, wherein the at least one of the four different nucleic of Norovirus GII.4 may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences, and wherein the at least one of the four of nucleic acid sequence of Norovirus Gl.l may be any one of the nucleic acid sequences as defined herein and in Table I, or fragment or variants of these sequences.

In a further preferred embodiment, the composition of the invention is defined as a composition comprising four different nucleic acid sequences (tetravalent composition), wherein three of the four different nucleic acid sequences are derived from Norovirus GII.4 and one of the four different nucleic acid sequence is derived from Norovirus Gl.l, wherein the three of the four different nucleic of Norovirus GII.4 may be any one of the nucleic acid sequences as defined in Table I, or fragment or variants of these sequences, and wherein the one of the four of nucleic acid sequence of Norovirus Gl.l may be any one of the nucleic acid sequences as defined in Table I, or fragment or variants of these sequences. Preferably, the composition comprising four different nucleic acid sequences (tetravalent composition) comprises or consists of three nucleic acid sequence derived from Norovirus GII.4 selected from SEfl ID NOs: 39713-39721, 3972B-39742 and one nucleic acid sequence derived from Norovirus Gl.l SEQ ID NOs: 39722-39725. In a specific preferred embodiment, the composition comprising four different nucleic acid sequences (tetravalent composition) comprises three of the nucleic acid sequences derived from Norovirus GII.4 selected from SEQ ID NOs: 397I6. 3972I, 3372B, 39734 or 39738 and one nucleic acid sequence derived from Norovirus Gl.l SEQ ID NO: 39725.

5

In further a preferred embodiments, the composition of the invention is defined as a composition comprising multiple different nucleic acid sequences (multivalent composition) defined as a composition comprising 5, G, 7, 8, 9, ID, II, I2, 13, 14, 15, IB, I7, 18, I9, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31. 32, 33, 34, 35, 36. 37, 38, 39, 4Q, 41, 42, 43. 44, 45, 4G, 47, 48, 49, 50, 51, 52. 53, 54, 55, 56, 57, 58, 59, 60.61, 62, 63, 64, 65, 66, 67, 68, 69, 7D, 71, 72.73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83. 84, 85. 86. 87. 88, I0 89, 90, 9I, 92, 93, 94, 95, 96, 97, 98, 99, 100 different nucleic acid sequences derived from Norovirus Gl.l, Norovirus GI.2, Norovirus GI.3, Norovirus GI.4, Norovirus GI.5, Norovirus GI.6, Norovirus GI.7, Norovirus GI.8, Norovirus GI.9, Norovirus Gll.l, Norovirus GHZ Norovirus GII.3, Norovirus GII.4, Norovirus GII.5, Norovirus GII.6, Norovirus GII.7, Norovirus Gll.ll, Norovirus GII.I2, Norovirus GII.I3, Norovirus GII.I4, Norovirus GII.I5, Norovirus GII.I6, Norovirus GII.I7, Norovirus GII.2I, Norovirus Glll.l, Norovirus GV.I or Norovirus GIV.I.

I5

In further a preferred embodiments, the composition of the invention is defined as a composition comprising multiple different nucleic acid sequences (multivalent composition) defined as a composition comprising 5, 6, 7, 8, 9,I0, II, I2, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 7, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 0, 1, 2, 43, 4, 45, 46.47, 48, 49, 5D, 51, 52, 53, 54, 55, 56. 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84. 85.8G, 87, 88, 89,0 90, 9I, 92, 93, 94, 95, 96, 97, 98, 99, 100 different nucleic acid sequences selected from Table 3 (column 4 and column 5). In Table 3, each row (row I - row I38) corresponds to selected Norovirus protein or antigen as identified by the respective name (first column, column I "Strain/Isolate") and the database accession number of the corresponding protein (second column, column 2 "NC6I or Genbank Accession No."). The third column, column 3 ("A") in Table 3 indicates the SEQ ID NOs corresponding to the respective amino acid sequence as provided herein. The SEQ ID NOs corresponding to the nucleic acid sequence of the wild5 type nucleic acid sequence encoding the Norovirus protein or peptide is indicated in the fourth column, column 4 ("B"). The fifth column, column 5 ("C") provides the SEQ ID NOs corresponding to modified nucleic acid sequences of the nucleic acid sequences as described herein that encode the Norovirus protein or peptide preferably having the amino acid sequence as defined by the SEQ ID NOs indicated in the third column ("A") or by the database entry indicated in the second column ("NCBI or Genbank Accession No.").

0 Table 3: Selected VPI Norovirus sequences (row I - row I38)

column column column column column

I 2 3 4 5

Row Strain/Isolate NCBI or A FJ C

Geribank

Accession

I Norovirus Hu/GII.4/Dijon/E872/2002/FRA AC055068 2 4412 8822,13232,17042, 2052,

26462,30872, 35282

2 Norovirus Hu/Gll.4/MDI2D-I2/I987/USA AFS33552 IB 442B 8836, 1324G, 17656, 220B6,

2B476, 30886, 3529B

3 Norovirus Hu/Gll.l/7EK/Hawaii/I97l/USA AFS33555 17 4427 8837,13247,17657, 22067,

26477,30887,35297

4 Norovirus Hu/GII.G/CHDC4D73/I984/USA AFX7IGG5 27 4437 8847,13257,17667, 22077,

26487,30897,35307

5 Norovirus Hu/Gil.4/Hiroshima/13/200i/JPN BAI49904 327 4737 9147,13557, 17967,22377,

26787, 31197,35607

6 Norovirus Hu/GII.4/Hiroshima/67/2006/JPN BAI499I4 335 4745 9155, 13565, 17975,22385,

26795, 31205, 35BI5

7 Norovirus BASD2D83 3B4 4774 9184.13594,18004, 22414,

Hu/GII/JP/2QI5/GII.Pe_GII.4/Dsaka/QSF78 26824,31234,35644

8 Norovirus Gll/Hu/NL/20I2/Gll.4/Groningen CRL4G958 3B7 4777 9187.13597,18007, 22417,

26827, 31237,35647

9 Norovirus Gll/Hu/Nt/20I4/Gll.2/Groningen CRL4BB73 372 4782 9192,13602,18012, 22422,

26832, 31242,35652

ID Norovirus Hu/GII.4/New Drleansl500/2DD8/ySA ADB27D27 37B 478B 9I9B, 13606,18016,22426,

26836, 31246,35656

II Norovirus Hu/GII.B/Dhio/49D/20I2/USA AGI9B397 38B 479B 9206,13616,18026, 22436,

2G84B, 31256,35666

I2 Norovirus Hu/GII.3/Jingzhou/2DI34D2/CHN AGX0I095 391 4801 9211,13621,18031,22441,

26851, 31261,35671

I3 Norovirus Hu/Gll.4/Jingzhou/20I34D3/CHN AGXDI098 392 4802 9212,13622,18032, 22442,

26852,31262,35672

I4 Norovirus Hu/GIU7/Gaithersburg/20l4/US AKI3DDB0 393 48D3 9213, 13623, 18033, 22443,

26853, 3I2B3, 35673 I5 Noravirus Hu/BII.4/CI27/GF/l978 AGL984I3 4D4 4814 9224.13B34, 18044, 22454,

2B8B4, 31274, 35B84

IB Norovirus Hu/GII.4/CHDC3967/l988/US ACT7BI45 458 48B8 9278, 13B88.18098, 22508,

2B9I8, 31328,35738

I7 Norovirus Hu/GII.4/CHDC4ID8/l987/US ACT7BI48 459 48B9 9279, 13B89, 18099, 2509,

26919.31329,35739

I8 Nornvirus Hu/GII.4/CHDC487l/l977/US ACT7BI5I 4BD 4870 928D, 13690,18100, 22510,

26920, 31330,35740

I9 Noravirus Hu/B!L3/CH0C52Bl/19B0/US AED02034 5DI 4911 9321,13731, 18141, 22551,

2B9BI, 31371, 35781

ZD Norovirus Hu/GII.3/MilwaukeB009/20l0/0SA AEXID549 534 4944 9354, 13764.18174, 22584,

26994, 31404,35814

2I NorovirusHu/BII.4/Miranda/NSW8l7L/2DI0/AU AFJ2I448 597 5D07 9417,13827,18237,22647,

27057, 31467,35877

22 Norovirus Hu/Gll.2/LI09/MY/I978 AFNDB72B B03 5DI3 9423,13833,18243,22653,

27DB3, 31473, 35883

23 Noravirus Hu/Gll.l4/HK74/CN/I978 AFNDB727 BD4 5014 9424,13834,18244, 22B54,

27064.31474,35884

24 Noravirus Hu/Gll.7/H4/CN/I97B AFNDB73I BD8 5018 9428,13838,18248,22658,

270B8, 31478,35888

25 Noravirus Hu/BII.I7/CI42/GF/l978 AFN0B732 BOB 5019 9429, 13839,18249, 22659,

27DB9, 31479,35889

2B Noravirus Hu/BII.5/CI5/GF/l978 AFN0B733 BIO 5020 9430,13840,18250, 22660,

2707D, 31480,35890

27 Norovirus Hu/Bl.5/E57/0B/I975 AFN0B735 BI2 5022 9432, 13842,18252,22662,

27072, 31482,35892

28 Noravirus Hu/BII.4/Randwick/NSW882J/20ll/AD AFVD877I GIB 502B 943B, 13846.18256, 22B66,

27076, 31486,35896

29 Norovirus Hu/BII.4/Berowra/NSW7B7L/2DI2/AU AFVD8777 GI8 5028 9438,13848,18258,22668,

27078.31488,35898

3D Norovirus Hu/BII.4/Sydoey/NSW05l4/20l2/AU AFV08795 B24 5D34 9444,13854,18264, 22674,

27084,31494.35904

3I Norovirus Hu/BII.4/Hong AFX9594D B25 5D35 9445,13855,18265, 22675, ong/CDHK3630/20I2/CHN 27085, 31495,35905 Norovirus Hu/GII.4/VPII72/Shanghai/20l2/CHN AGI99552 629 5039 9449,13859,18269,22679,

27D89, 31499,35909

Norovirus HU/GII-4/NBW Taipei/CG H6l/2QI2/TW AG 259I2 B44 5054 9464, 13874,18284, 22694,

27104, 31514.35924

Norovipus GII/Hu/HKG/2D13/Bil.4/GUHK-NS-i4l AIDG858I 859 5269 9679, 14089,18499.22909,

27319,31729,36139

Narovirus AII737I7 877 5287 9697,14107,18517, 22927,

GII/Hu/JP/2D02/GII.PI2_GII.!3/Saitama/T80 27337, 31747, 3GI57

Norovirus AII73735 883 5293 9703,14113,18523,22933,

GII/Hu/JP/200l/GII.P!2_GI!.l2/Saitama/TI5 27343, 31753,36163

Norovirus AII7374I 885 5295 9705.14115,18525,22935,

GII/Hu/JP/2007/GII.P2l_GII.2l/ awasaki/Y0284 27345, 31755.3BIB5

Norovirus AII73759 891 5301 9711, 14121,18531,22941,

GII/Hu/JP/2007/GII.PI5_GII.I5/Sapporo/HK299 27351, 31761, 36171

Norovirus AII73765 893 5303 9713, 14123, 18533, 22943,

GI/Hu/JP/2DD7/GI.P3_BI.3/Shimizu/ K28BB 27353, 31763,36173

Norovirus AII73780 898 5308 9718, 14128,18538,22948,

GII/Hu/JP/2007/GII.P7_GII.I4/Fukuoka/ K282 27358, 31768,36178

Norovirus AII73783 899 5309 9719, 14129,18539.22949,

GI/Hu/JP/2007/GI.P8_GI.8/Nagoya/KY53l 27359, 31769,36179

Narovirus Hu/Gll.4/SJT0HI/CHN/20I4 AIS400I9 901 5311 9721, 14131,18541,22951,

27361, 31771, 3BI8I

Norovirus Hu/GII.4/variant Sydney 2012/FRA AIY27747 930 5340 9750.14160.18570,22980,

27390, 31800,36210

Norovirus Hu/GII-4/Hokkaido4/200G/JP BA670437 1033 5443 9853, 14263.18673,23083,

27493,31903,36313

Norovirus GIV/Hu/Jp/20DI/GIV.I/OBOIOI7023 BAUI6306 1345 5755 10165, 14575,18985, 23395,

278D5, 32215,36625

Narovirus Hu/GII.4/Beijing/53G7l/2Q07/CHN ABY00BI5 1454 5864 10274, 14684,19094,23504.

27914, 32324,36734

Norovirus Hu/ll.4/22006BI/H /20IO AD 47I70 1467 5877 10287,14697,19107, 23517,

27927, 32337,36747

Narovirus Hu/Gll.4/Aichi368-I4/2DI4 BAD2080I 1477 5887 10297, 14707, 19117, 23527,

27937, 32347,36757 43 Noravirus Hu/GII.4/Hunter 284E/040/AU AAZ3I37B I552 5962 ID372, 14782.13(82, 23BD2,

28DI2, 32422,36832

5D Naravirus Hu/G!l-4/Dsaka/fB9B/JPN ABI9798I I5B9 5979 ID389, 14799,19209, 23BI9,

28B29, 32439, 3B849

5I Noravirus ABW74I28 IBID BD2D 10430,14840,19250, 23GB0,

Hu/Bl.f/P774.Delsjo2DD4/Bothenburg/Sweden 28070, 32480,36890

52 Noravirus pig/GII.I!/FI8-IG/2005/CAN ACCB9023 IB29 BD39 10449, 14859, 192B9, 23679,

28089, 32499,36909

53 Noravirus Hu/Gll.4/Wellingtan/I935/USA ACL27297 IG70 6D80 10490,14900,19310, 23720,

28130,32540,36950

54 Noravirus Hu/GII.4/Henry/2000/USA ACL27298 IB7I B08I 10491, 14901,19311,23721,

28131, 32541, 3B95I

55 Noravirus Hu/GII.4/SSCS/2DD5/USA ACL27299 IB72 BD82 10492, 14902,10312,23722,

28132, 32542,36952

5G NorovirusGII/Hu/IN/20DG/GII.P4_GII.4_ ACL3I322 IB8D BD90 10500, 14910,19320, 23730.

YErseke2QQGa/Pune-PC2l 28140, 32550, 369B0

57 Naravirus Hu/GI.I/P7- ACN32270 IG92 BID2 10512,14922,19332, 23742, 587/2007/Stromstad/SwBden 28152, 32562,36972

58 NarovirusHu/GI.2/L _E uvBn/2DB3/BEL ACU5B258 IB98 BID8 10518, 14928,10338,23748,

28158, 32568,36978

53 Noravirus Hu/GII.7/NSW743L/ZDD8/AUS ACX858ID I7I2 BI22 10532,14942,19352,23762,

28172, 32582,36992

BD Noravirus Hu/GII.2/NF2DD2/USA/2DD2 AFBI8DI0 I73I 6I4I 10551,14961,19371,23781,

28191, 32601.37011

B! Noravirus Hu/GII.4/NF2003/0SA/2003 AFBI8013 I732 BI42 10552,14962,19372, 23782,

28192, 32602,37012

B2 Noravirus Hu/Gll.3/I393 AF75854 I739 BI49 10559, 14969,10379,23783,

28199, 32609,37019

B3 NarovirusHu/GIV.I/AhrBnshaa _P 24G/DEU/20l2 AFNB13I5 I74D BI5D 10560, 14970,10380,23790,

28200, 32610,37020

B4 Noravirus Hu/GII.4/Xi an/P!9/2DI0/CHN AFQDD5II I74I 6I5I 10561, 14971,19381,23791,

282DI, 32611, 37021

B5 Noravirus Hu/GII.4/PA3G3/20ll/ITA AHCI2B55 I770 BI8D 10590, 15000,10410, 2382D,

28230,32640,37050 BB Norovirus Hu/GII.4/P3/2DI2/GothBnburg/SwEdBn AHZI29I2 I778 BI88 10598,15008, 19418.23828,

28238, 32648,37058

B7 Norovirus Hu/GII.4/Tanger/TM687/20ll/MAR AIC32559 I787 BI97 10607, 15017,19427,23837,

28247, 32657,37067

B8 Norovirus I2-X-2/20I2/GII.P22/GII.5 AI05I489 I793 B203 10613.15023, 19433, 23843.

28253, 32663,37073

B9 Norovirus Hu/GII.4/obe034/2006/JP BAF458BI I82B B23B 10646, 15056,19466, 23876,

28286, 32696,37106

70 Norovirus Hu/GGII.4/Tiel00l/I995/NL BAF74508 I827 B237 10647,15057,19467, 23877,

28287, 32697,37107

7I NorQvirusHu/GGII.4/DenHaagOI5/2000/NL BAF74509 I828 B238 10648, 15058,19468.23878.

28288, 32698,37108

72 Norovirus Hu/GGII.4/SchiBdamOI8/200l/NL BAF745I2 I83I B24I 10651,15061,19471,23881,

28291, 32701, 37111

73 Norovirus Hu/GGII.4/Apeldoorn023/2003/NL BAF745I7 I83B G24B I0B5B, 15066,19476,23886,

28296, 32706,37116

74 Norovirus Hu/GGll.4/Middelburg007/20D4/NL BAF7452I I840 B250 10660,15070,19480.23890,

28300.32710,37120

75 Norovirus Hu/GII-4/Matsudo/02l07l/2D02/JP BAF95499 I847 B257 10667,15077,19487, 23897,

28307.32717, 37127

7B Norovirus Hu/GII-4/Kaiso/030556/2003/JP BAF9550I I848 B258 10668,15078,19488,23898.

28308, 32718,37128

77 Norovirus Hu/GII-4/Awa/040354/2004/JP BAF95505 I850 B2B0 10670,15080,19490.23900,

28310, 32720,37130

78 Norovirus Hu/GII.4/Apeldoorn3l7/2007/NL BAG55289 I885 6295 10705.15115,19525.23935,

28345, 32755,37165

79 Norovirus Hu/GII.2/RottBrdam39E/2002/NL BAGB87I3 I89I B30I 10711,15121,19531,23941,

28351, 327BI, 37171

80 Norovirus Hu/GII.4/RotterdamP2Du72005/NL BAGB880I I897 6307 10717.15127,19537,23947.

28357,32767,37177

8! Norovirus Hu/Gll.4/Stockholm/I98B5/2008/SE BAH30707 I9IB 6326 I073B.15146,19556.23966.

28376, 32786,37196

82 Norovirus Hu/GII.G/0C040B2VLP/2004/JP BAL40873 I92I 633I 10741.15151,19561,23971,

28381,32791,37201 83 Norovirus Hu/BII.4/HSI94/2D03/US ADB279I4 I96I B37I I078I, I5I9I,I9B0I,240II,

28421, 328313724I

84 Norovirus Hu/GII.12/HS210/20l0/0SA ADT70684 I965 6375 10785, 15195,19605,24015,

28425, 32835,37245

85 Narovirus Hu/GI.I/8Flla/l968/USA AFJ385IB I97B 6380 10790, 15200, IBGID.24020,

28430, 32840,37250

86 Norovirus Hu/Gll.4/CHDC5I9I/I974/USA AFJ385I9 I97I B38I 10791,15201,19611,24021,

28431,32841.37251

87 Norovirus Hu/GII.4/N76/2DID/HuZhou AFWI5943 I975 6385 10795,15205,19615.24025,

28435, 32845,37255

88 Norovirus Hu/GII.B/S9c/I976/SEN AGE99599 2D0D 64I0 10820, 15230,19640.24050,

28460, 32870,37280

83 Norovirus Hu/Gll.4/L45/I978/MYS AGE996I2 2D0I 64I! ID821, 15231, 19641, 24051,

28461, 32871,37281

9D Norovirus Hu/GII.4/NIHICI7.5/2DI2/USA AGTI7839 2DB5 64I5 10825, 15235,19645,24055,

28465,32875,37285

9I Norovirus Hu/GII.4/NIHIC9/2DII/USA AFX7I6G9 4I98 8608 13018, 17428,21838.26248,

30658, 35068,39478

92 Norovirus Hu/GII.4/CII0/l978/GUF AGE99607 4336 8746 13156, 17566,21976,26386,

30796, 35206,39616

93 Norovirus Hu/GII.4/HS66/20DI/USA AHI59I6B 4379 8789 13199, 17609,22019,26429,

30839, 35249,39659

94 Norovirus BA42290 4395 8805 13215, 17625.22035,26445,

Hu/GII/JP/20l5/GII.PI7_Gll.l7/Kawasaki308 3D855, 35265.3BB75

95 Norovirus Hu/GII/JP/20l4/GII.PI7_GII.I7/Nagano8- BARB3722 4399 8809 13219.17629.22039.26449, I 30859, 35269,30679

96 Norovirus BASD2B84 4400 88I0 13220, 17630,22040,26450,

Hu/GII/JP/20l5/GII.PE_GII.4/Dsaka/DSF78 30860, 35270, 3968D

97 Norovirus Gl/Hu/NL/2QII/GI.4/Groningen CRL46953 440I 88II 13221, 17631,22041,26451,

30861,35271,30681

98 Norovirus GII/Hu/NL/2DI4/GII.4/GroningBnDI CRL46962 4404 88I4 13224,17634,22044,26454,

30864, 35274,30684

99 Norovirus Hu/GIU/KenEpuru/NZ327/20DG/NZL ABQ63283 20I8 6428 10838,15248,19658.24068,

28478,32888,37298 ιοο Norovirus ACWI9927 2023 B433 I0843, 15253.I9BB3, 24073,

Hu/BII.4/Rathmines/NSW287R/2DD7/AUS 28483, 32893,37303

IQI Norovirus ADD43783 2D3Z B442 I0852.I5ZBZ.19672,24082,

Hu/GII.4/Turratrarra/NSW8920/Z009/ADS 28492, 32902,37312

ID2 Norovirus HU/GII.4/SBDUI/D389/200B/ DR A0V37805 2033 B443 10853, 15263,19673,24083.

28493, 32903,37313

ID3 Norovirus Hu/BII.4/Seoul/0945/20D9/0R ADV379I9 2038 B448 10858, 15268,19678,24088,

28438, 32908,37318

ID4 Norovirus Hu/GII.I2/Shelby/20D9/USA AEI834B9 2039 B449 10859,15269,19679,24083,

28499, 32909,37319

I05 Norovirus Hu/GI.7/TCH-0G0/0SA/Z003 AEQ77282 204I B45I 10861, 15271.19681, 24091,

28501, 32911,37321

IDB Norovirus Hu/GII.I/Ascensio _n 208/20IO/OSA AFA55I74 2042 B452 10862, 15272,19682,24092.

28502.32912,37322

I07 Norovirus Hu/GII.I3/VAI73/20IO/OSA AFC83B5B 2043 B453 10863, 15273,19683,24093,

28503, 32913,37323

IDB Norovirus Hu/GII.2l/Salisburyl50/20ll/0SA AFC89665 204B B45B I08B6, 15276,19686.24096,

2850B.329IG.37326

IDB Norovirus Hu/Gll.4/I997/USA AFJ04707 204B B459 10869,15279.19683.24099.

28509.32919,37329

HO Norovirus Hu/GII.4/Farmington Hills/2004/USA AFJ047D8 2050 B4B0 10870, 15280,19690,24100,

28510, 32920, 37330

III Norovirus Hu/GII.4/Minerva/2006/DSA AFJD4709 Z05I B4BI 10871,15281,19691, 24101,

28511, 32921,37331

HZ Norovirus Hu/GII.4/0hio/7l/20l2/USA AFP89593 2052 B4B2 10872, 15282,19692,24102,

28512, 32922,37332

II3 Norovirus Flu/GII.4/AlbertaEI065/20ll/CA AF05573I 20B8 B478 10888, 15298,19708,24118,

285Z8, 3Z938, 37348

II4 Norovirus Hu/GII.4/SG405l-09/2009/SG AF0927I0 2II9 B529 10333.15349,19759,24169,

28579, 32989,37399

II5 Norovirus Hu/GII.3/TCH-l04/0SA/2002 AG0B4038 2I70 B580 10990, 15400, 19810, 24220,

28630, 33D4D, 37450

IIB Norovirus Hu/GI.G/TCH-D9B/USA/2003 AGTB252I 2I74 B584 10994,15404,19814.24224,

28634, 33044,37454 II7 Naravirus 0G-A -ll/2006/GII.4/YBrsekB/2006a AJZ77DD4 2228 BB38 11048,15458,19868, 24278,

28688,33098,37508

II8 Norovirus D9-Bi-2/2DD9/Gtl.4/NEwDrleans/2DD9 AJZ770I5 2231 BB4I 11051, 15461,19871,24281,

28691,33101,37511 no Naravirus Hu/Gll.4/PR328/20I3/ITA AKE3I86I 2242 BB52 11062,15472,19882.24292,

28702, 33112,37522

IZO Naravirus Hu/GII.PI7_GII.I7/PR6G8/2DI5/ITA ALDQ9BI8 2253 BBB3 11073,15483,19893.24303,

28713,33123.37533

I2I Naravirus Hu/GII.4/AlbBrtaSPI/2DI3/CA ALT54494 2274 BB84 11094, 15504, 19914, 243Z4,

28734.33144,37554

I22 Noravirus Hu/Gli.4/C00007B92/2011/UK CCX28BI9 2280 BB90 11100,15510,19920, 24330,

28740, 33150,37560

I23 Noravirus Hu/GII.G/GZ2DID-LB6/Guangzhou/ AGC96535 2330 B740 11150,15560,19970, 24380, CHN/20II 28790.33200,37610

I24 Noravirus Bo/GIII.I/Aba-Z5/20D2/HUN ABYB7257 2341 B75I IIIBI.15571, 19981, 24391,

28801, 33211, 37621

I25 Noravirus GI.9 AHA9IB5B 2342 B752 11162.15572,19982,24392,

28802,33212,37622

I2B Naravirus Hu/GII.I7/CUH -NS-B7Q/H G/2QI5 KT3I57I8 2488 B898 11308, 15718,20128,24538,

28948, 33358, 377B8

I27 Naravirus GII/Hu/SI/2DI5/GII.I7/LjubljaaalBBZ T59I5GI 2509 6919 11329,15739.20149,24559.

28969,33379,37789

I28 Norovirus Hu/GII.I7/CUH -NS-B47/H G/2DI5 KT3I570B 2529 B939 11349.15759,20169.24579.

28989,33399,37809

I29 Norovirus Hu/GII.ZI/CUH -NS-BDB/HKG/ZDI5 KR92I940 2540 6950 11360, 15770,20180,24590,

29000, 33410,37820

I30 Norovirus Hu/BII.4/MelbaurnBBB23/2DIB/AUS KX7B7D83 2B00 7010 11420,15830,20240, 24650,

29060,33470,37880

I3I Norovirus GII/Hu/JP/20IG/GII.PIB_GII.4_ LCI53I2I 2BB4 7074 11484.15894,20304,24714, Sydney20l2/0HIGD02 29124, 33534,37944

I32 Norovirus Hu/GII/JP/ZDIB/GII.PIG_GII.4_ LCI754B8 3556 70BB 12376, 16786, 21196, 25B0B,

SydnBy2DI2/Kawasakil94 30016,34426,38836

I33 Noravirus l6F2l49_GII.2_Guangdong_CHN_20IG KY485I25 2438 B848 11258,15668,20078,24488,

28898, 33308,37718 I34 Norovirus Hu/GII.17/CUH -NS-8G4/HKG/201B KU55584I 25B4 7004 11414. 15824, 20234, 24B44,

2S054, 33464, 37874

I35 Narc-virus KP784B96 2BI3 7023 11433, 15843, 20253, 24BB3,

Gll/Hu/ZAF/20i2/B!f.P4_Bif.4/CapeTDwn/3772 23073, 33483, 37893

I3B Norovirus GII.I2 KP064099 4D3B 844B I285B, 17266, 2IB76, 2B086,

3043B. 34306, 39316

I37 Snow Mountain virus U7D05B 2441 B85I II2BI, 15671, 20081, 24491,

28301, 33311, 37721

I38 Human calicivirus strain Melksham X8I879 2359 B7B9 11173, 15583, 19999, 24409,

28819, 33229, 37633

Preferably, the molar ratio of the complexed nucleic acid to the free nucleic acid is selected from a molar ratio of about 0.001:1 to about 1:0.001, including a ratio of about 1:1. In a preferred embodiment, the invention provides a composition comprising at least one artificial nucleic acid as described herein, wherein the ratio of complexed nucleic acid to free nucleic acid is selected from a range of about 5:1 (w/w) to about 1:10 (w/w), more preferably from a range of about 4:1 (w/w) to about 1:8 (w/w), even more preferably from a range of about 3:1 (w/w) to about 1:5 (w/w) or 1:3 (w/w), wherein the ratio is most preferably about 1:1 (w/w).

In one embodiment, at least one artificial nucleic acid as defined herein or any other nucleic acid comprised in the inventive (pharmaceutical) composition or vaccine can also be associated with a vehicle, transfection or complexation agent for increasing the transfection efficiency and/or the immunostimulatory properties of the at least one artificial nucleic acid or of optionally comprised further included nucleic acids.

In the context of the present invention, a cationic or polycationic compound is preferably selected from any cationic or polycationic compound, suitable for complexing and thereby stabilizing a nucleic acid, particularly the at least one artificial nucleic acid of the inventive composition, e.g. by associating the at least one artificial nucleic acid with the cationic or polycationic compound. Such a cationic or polycationic compound per se does not need to exhibit any adjuvant properties, since an adjuvant property, particularly the capability of inducing an innate immune response, is preferably created upon complexing the at least one artificial nucleic acid with the cationic or polycationic compound. When complexing the at least one artificial nucleic acid with the cationic or polycationic compound, the adjuvant component is formed.

Particularly preferred, cationic or polycationic peptides or proteins (preferably also as component P ² in a polymeric carrier according to formula IV herein) may be selected from protamine, nucleoline, spermine or spermidine, poly-L-lysine (PLL), basic polypeptides, poly-arginine, cell penetrating peptides (CPPs), chimeric CPPs, such as Transportan, or MPG peptides, HIV-binding peptides, Tat. HIV-I Tat (HIV), Tat-derived peptides, oligoarginines, members of the penetratin family, e.g. Penetratin, Antennapedia-derived peptides (particularly from Orosophila antennapedia), pAntp, plsl, etc., antimicrobial-derived CPPs e.g. Buforin-2, Bac7l5-24. SynB, SynB(l), pVEC. hCT-derived peptides, SAP, MAP, KALA, PpTG2B, Proline-rich peptides, L-Dligomers, Arginine-rich peptides, Calcitonin-peptides, FGF, Lactoferrin, poly-L-Lysine, pnly-Arginine, histones, VP22 derived or analog peptides, HSV, VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpTB2D, prolin-rich peptides, arginine- rich peptides, lysine-rich peptides, Pep-I, Calcitonin peptide(s), etc.

5

According to a preferred embodiment, cationic or polycationic proteins or peptides are selected from the following proteins or peptides having the following total formula (III):

(Arg)i;(Lysk(His)„;(Orn)„;(Xaa)», formula (III)

ID

wherein l + m + n +o + x = 8-I5, and I, m, n or o independently of each other may be any number selected from D, 1, 2, 3, 4, 5, B, 7. 8. 9, ID, II, I2, 13, 14 or 15, provided that the overall content of Arg, Lys, His and Orn represents at least 50% of all amino acids of the oligopeptide; and Xaa may be any amino acid selected from native (= naturally occurring) or non-native amino acids except of Arg, Lys, His or Dm; and x may be any number selected from D, 1.2, 3, 4, 5, B, 7, or 8, provided, that the overall content of Xaa 15 does not exceed 5D% of all amino acids of the oligopeptide. Preferred cationic peptides in this context are e.g. Arg ₇ , Args, Argg, Ms. RgHs, H3R9H3, YSSRgSSY. (RKHk Y(RKH) _Z R, etc. In this context the disclosure of WD 2DDB/D3D48I is incorporated herewith by reference.

Further preferred cationic or polycationic compounds, which can be used for complexing the at least one artificial nucleic acidD according to the invention may include cationic polysaccharides, for example chitosan, polybrene, cationic polymers, e.g. polyethyleneimine (PEI), cationic lipids, e.g. DDTMA: [l-(2,3-sioleyloxy)propyl)]-N,N,N-trimethylammonium chloride, DMRIE, di-CI4- amidine, DDTIM, SAINT, DC-Chol, BGTC, CTAP, DOPC, DODAP, DOPE: Dioleyl phosphatidylethanol-amine, DDSPA, DDDAB, DDIC, DMEPC, DDGS: Dioctadecylamidoglicylspermin, DIMRI: Dimyristo-oxypropyl dimethyl bydroxyethyl ammonium bromide, DOTAP: dioleoyloxy-3-(trimethylammonio)propane, DC-B-14: D,D-ditetradecanoyl-N-(a-trimethylammonioacetyl)diethanolami ne5 chloride, C LIP i: rac-[(2.3-dioctadecyloxypropyl)(2-hydroxyethyl)]-dimethylamm onium chloride, CLIPG: rac-[2(2,3- dihexadecyloxypropyl-oxymethyloxy)ethyl]trimethylammonium, CLIPB: rac-[2(2,3-dihexadecyloxypropyl-oxysuccinyloxy)ethyl]- trimethylammonium, oligofectamine, or cationic or polycationic polymers, e.g. modified polyaminoacids, such as β-aminoacid- polymers or reversed polyamides, etc., modified polyethylenes, such as PVP (poly(N-ethyl-4-vinylpyridinium bromide)), etc., modified acrylates, such as pDMAEMA (poly(dimethylaminoethyl methylacrylate)), etc., modified amidoamines such as pAMAMD (pDly(amidoamine)), etc., modified polybetaaminoester (PBAE), such as diamine end modified 1,4 butanediol diacrylate-co-5- amino-t-pentanol polymers, etc., dendrimers, such as polypropylamine dendrimers or pAMAM based dendrimers, etc., polyimine(s), such as PEL poly(ethyleneimine), poly(propyleneimine), etc., polyallylamine, sugar backbone based polymers, such as cyclodextrin based polymers, dextran based polymers, chitosan, etc., silan backbone based polymers, such as PMDXA-PDMS copolymers, etc., blockpolymers consisting of a combination of one or more cationic blocks (e.g. selected from a cationic polymer5 as mentioned above) and of one or more hydrophilic or hydrophobic blocks (e.g. polyethyleneglycole); etc. Association or complexing the at least one artificial nucleic acid of the inventive composition with cationic or polycationic compounds preferably provides adjuvant properties to the at least one artificial nucleic acid and confers a stabilizing effect to the at least one artificial nucleic acid of the adjuvant component by complexation. The procedure for stabilizing the at least one artificial nucleic acid is in general described in EP-A-I083232, the disclosure of which is incorporated by reference into the present invention in its entirety. 5 Particularly preferred as cationic or polycationic compounds are compounds selected from the group consisting of protamine, nucleoline, spermin, spermidine, oligoarginines as defined above, such as Arg?, Args, Args, Arg?, HSRB. gHs. HsRaHs, YSS aSSY. (RKHk Y(RKH)zR, etc.

According to a preferred embodiment, the inventive composition is formulated by using the at least ooe artificial nucleic acid ID according to the invention and one or more liposomes, lipoplexes, or lipid nanoparticles. In one embodiment, the inventive composition comprises liposomes. Liposomes are artificially-prepared vesicles, which may primarily be composed of a lipid bilayer and may be used as a delivery vehicle for the administration of nutrients and pharmaceutical formulations. Liposomes can be of different sizes such as, but not limited to, a multilamellar vesicle (MLV) which may be hundreds of nanometers in diameter and may contain a series nf concentric bilayers separated by narrow aqueous compartments, a small unicellular vesicle I5 (SUV) which may be smaller than 50 nm in diameter, and a large unilamellar vesicle (LUV) which may be between 5D and 500 nm in diameter. Liposome design may include, but is not limited to, opsonins or ligands in order to improve the attachment of liposomes to unhealthy tissue or to activate events such as, but not limited to, endocytosis. Liposomes may contain a low or a high pH in order to improve the delivery of the inventive composition, in particular when applied as a pharmaceutical composition or a vaccine as described herein.

0

According to a preferred embodiment, the inventive composition comprises the artificial nucleic acid as described herein and a polymeric carrier. A polymeric carrier used according to the invention might be a polymeric carrier formed by disulfide- crosslinked cationic components. The disulfide-crosslinked cationic components may be the same or different from each other. The polymeric carrier can also contain further components. It is also particularly preferred that the polymeric carrier used in5 the composition according to the present invention comprises mixtures of cationic peptides, proteins or polymers and optionally further components as defined herein, which are crosslinked by disulfide bonds as described herein. In this context, the disclosure of W0 20I2/0I332B is incorporated herewith by reference.

In this context, the cationic components, which form basis for the polymeric carrier by disulfide-crosslinkage, are typically0 selected from any suitable cationic or polycationic peptide, protein or polymer suitable for this purpose, particular any cationic or polycationic peptide, protein or polymer capable to complex the at least one artificial nucleic acid as defined herein or a further nucleic acid comprised in the composition, and thereby preferably condensing the mRNA or the nucleic acid. The cationic or polycationic peptide, protein or polymer, is preferably a linear molecule, however, branched cationic or polycationic peptides, proteins or polymers may also be used.

5 Every disulfide-crasslinking cationic or polycationic protein, peptide or polymer of the polymeric carrier, which may be used to complex the at least one artificial nucleic acid or any further nucleic acid comprised in the inventive (pharmaceutical) composition or vaccine contains at least one -SH moiety, most preferably at least one cysteine residue or any further chemical group exhibiting an -SH moiety, capable to form a disulfide linkage upon condensation with at least one further cationic or 5 polycationic protein, peptide or polymer as cationic component of the polymeric carrier as mentioned herein.

As defined above, the polymeric carrier, which may be used to complex the at least one artificial nucleic acid or any further nucleic acid comprised in the inventive (pharmaceutical) composition or vaccine may be formed by disulfide-crosslinked cationic (or polycationic) components. Preferably, such cationic or polycationic peptides or proteins or polymers of the polymeric carrier, I0 which comprise or are additionally modified to comprise at least one -SH moiety, are selected from, proteins, peptides and polymers as defined above for complexation agent.

In a further particular embodiment, the polymeric carrier which may be used to complex the at least one artificial nucleic acid or any further nucleic acid comprised in the inventive (pharmaceutical) composition or vaccine may be selected from a polymeric I5 carrier molecule according to generic formula (IV):

L-P'-S-[S-P ^Z -S]„-S-P ³ -L formula (IV) wherein,

D P' and P ³ are different or identical to each other and represent a linear or branched hydrophilic polymer chain, each P' and P ³ exhibiting at least one -SH-moiety, capable to form a disulfide linkage upon condensation with component P ^z , or alternatively with (AA), (AA)*. or [(AA)«] _Z if such components are used as a linker between P' and P ² or P ³ and P ^z ) and/or with further components (e.g. (AA), (AA)*, [(AA) _x ] ₂ or L), the linear or branched hydrophilic polymer chain selected independent from each other from polyethylene glycol (PEG), paly-/ (2-hydroxypropyl)methacrylamide,5 poly-2-(methacryloyloxy)ethyl phosphorylcholines, poly(hydroxyalkyl L-asparagine). poly(2-(methacryloyloxy)ethyl phosphorylcholine), hydroxyethylstarch or poly(hydroxyalkyl L-glutamine), wherein the hydrophilic polymer chain exhibits a molecular weight of about I kDa to about IOD kDa, preferably of about 2 kDa to about 25 kOa; or more preferably of about 2 kDa to about I0 kDa, e.g. about 5 kDa to about 25 kDa or 5 kDa to about ID kDa;

is a cationic or polycationic peptide or protein, e.g. as defined above for the polymeric carrier formed by disulfide-D crosslinked cationic components, and preferably having a length of about 3 to about IDO amino acids, more preferably having a length of about 3 to about 5D amino acids, even more preferably having a length of about 3 to about 25 amino acids, e.g. a length of about 3 to ID, 5 to I5, ID to 2D or I5 to 25 amino acids, more preferably a length of about 5 to about 2D and even more preferably a length of about ID to about 2D; or

is a cationic or polycationic polymer, e.g. as defined above for the polymeric carrier formed by disulfide-crosslinked5 cationic components, typically having a molecolar weight of about D.5 kDa to about 3D kDa, including a molecular weight of about I kDa to about 2D kDa, even more preferably of about I.5 kDa to about ID kDa, or having a molecular weight of about D.5 kDa to about IDD kDa, including a molecular weight of about ID kDa to about 5D kDa, even more preferably of about ID kDa to about 3D kDa;

each P ² exhibiting at least two -SH-moieties, capable to form a disulfide linkage upon condensation with further components P ² or component(s) P' and/or P ³ or alternatively with further components (e.g. (AA), (AAk or [(AA)Jz);

-S-S- is a (reversible) disulfide bond (the brackets are omitted for better readability), wherein S preferably represents sulphur or a -SH carrying moiety, which has formed a (reversible) disulfide bond. The (reversible) disulfide bond is preferably formed by condensation of -SH-moieties of either components P ^! and P ^z , P ² and P ² , or P ² and P ³ , or optionally of further components as defined herein (e.g. L, (AA), (AA)¾ [(AA)xL, etc); The -SH-maiety may be part of the structure of these components or added by a modification as defined below;

L is an optional ligand, which may be present or not, and may be selected independent from the other from BD,

Transferrin, Folate, a signal peptide or signal sequence, a localization signal or sequence, a nuclear localization signal or sequence (NLS), an antibody, a cell penetrating peptide, (e.g. TAT or KALA), a ligand of a receptor (e.g. cytokines, hormones, growth factors etc), small molecules (e.g. carbohydrates like mannose or galactose or synthetic ligands), small molecule agonists, inhibitors or antagonists of receptors (e.g. RGD peptidomimetic analogues), or any further protein as defined herein, etc.;

n is an integer, typically selected from a range of about I to 50, preferably from a range of about 1, 2 or 3 to 30, more preferably from a range of about 1, 2, 3, 4, or 5 to 25, or a range of about 1, 2, 3, 4. or 5 to 20, or a range of about I, 2, 3, , or 5 to I5, or a range of about 1, 2, 3, 4, or 5 to ID, including e.g. a range of about 4 to 9, 4 to I0, 3 to 20, to 20, 5 to 20, or I0 to 20, or a range of about 3 to I5, 4 to I5, 5 to I5, or ID to I5, or a range of about G to II or 7 to ID. Most preferably, n is in a range of about 1, 2, 3, , or 5 to ID, more preferably in a range of about 1, 2, 3, or 4 to 9, in a range of about 1, 2, 3, or 4 to 8, or in a range of about 1, 2, or 3 to 7.

In this context, the disclosure of WD 2DII/D2G64I is incorporated herewith by reference. Each of hydrophilic polymers P' and P ³ typically exhibits at least one -SH-moiety. wherein the at least one -SH-moiety is capable to form a disulfide linkage upon reaction with component P ² or with component (AA) or (AA)*, if used as linker between P' and P ² or P ³ and P ² as defined below and optionally with a further component, e.g. L and/or (AA) or (AA) _X , e.g. if two or more -SH-moieties are contained. The following subformulae "P'-S-S-P ² " and "P ² -S-S-P ³ " within generic formula (IV) above (the brackets are omitted for better readability), wherein any of S, P' and P ³ are as defined herein, typically represent a situation, wherein one-SH-moiety of hydrophilic polymers P' and P ³ was condensed with one -SH-moiety of component P ² of generic formula (IV) above, wherein both sulphurs of these -SH-moieties form a disulfide bond -S-S- as defined herein in formula (IV), These -SH-moieties are typically provided by each of the hydrophilic polymers P' and P ³ e.g. via an internal cysteine or any further (modified) amino acid or compound which carries a -SH moiety. Accordingly, the subformulae "P'-S-S-P ² " and "P ² -S-S-P ³ " may also be written as "P'-Cys-Cys-P ² " and "P ² -Cys-Cys-P ³ ", if the - SH- moiety is provided by a cysteine, wherein the term Cys-Cys represents two cysteines coupled via a disulfide bond, not via a peptide bond. In this case, the term "-S-S-" in these formulae may also be written as "-S-Cys", as "-Cys-S" or as "-Cys-Cys-". In this context, the term "-Cys-Cys-" does not represent a peptide bond but a linkage of two cysteines via their -SH-moieties to form a disulfide bond. Accordingly, the term "-Cys-Cys-" also may be understood generally as "-(Cys-S)-(S-Cys)-", wherein in this specific case S indicates the sulphur of the -SH-moiety of cysteine. Likewise, the terms "-S-Cys" and "-Cys-S" indicate a disulfide bond between a -SH containing moiety and a cysteine, which may also be written as "-S-(S-Cys)" and "-(Cys-S)-S". Alternatively, the hydrophilic polymers P' and P ³ may be modified with a -SH moiety, preferably via a chemical reaction with a compound carrying a -SH moiety, such that each of the hydrophilic polymers P' and P ³ carries at least one such -SH moiety.

5 Such a compound carrying a -SH moiety may be e.g. an (additional) cysteine or any further (modified) amino acid, which carries a -SH moiety. Such a compound may also be any non-amino compound or moiety, which contains Dr allows to introduce a -SH moiety into hydrophilic polymers P' and P ³ as defined herein. Such non-amino compounds may be attached to the hydrophilic polymers P' and P ³ of formula (IV) of the polymeric carrier according to the present invention via chemical reactions or binding of compounds, e.g. by binding of a 3-thio propionic acid or thioimolane, by amide formation (e.g. carboxylic acids, sulphonic acids,

I0 amines, etc), by Michael addition (e.g maleinimide moieties, α,β-unsatured carbonyls, etc), by click chemistry (e.g. azides or alkines), by alkene/alkine methatesis (e.g. alkenes or alkines), imine or hydrozone formation (aldehydes or ketons, hydrazins, hydroxylamins, amines), complexation reactions (avidin, biotin, protein G) or components which allow S _n -type substitution reactions (e.g halogenalkans, thiols, alcohols, amines, hydrazines, hydrazides, sulphonic acid esters, oxyphosphonium salts) or other chemical moieties which can be utilized in the attachment of further components. A particularly preferred PEG derivate in

I5 this context is alpha-methoxy-omega-mercapto polyethylene glycol). In each case, the SH-moiety, e.g. of a cysteine or of any further (modified) amino acid or compound, may be present at the terminal ends or internally at any position of hydrophilic polymers ' and P ³ . As defined herein, each of hydrophilic polymers P' and P ³ typically exhibits at least one -SH-moiety preferably at one terminal end, but may also contain two or even more -SH-moieties, which may be used to additionally attach further components as defined herein, preferably further functional peptides or proteins e.g. a ligand, an amino acid component (AA) or0 (AA)x, antibodies, cell penetrating peptides or enhancer peptides (e.g. TAT, KALA), etc.

The complexed artificial nucleic acid in the inventive (pharmaceutical) composition or vaccine, is preferably prepared according to a first step by complexing the at least one artificial with a cationic or polycationic compound and/nr with a polymeric carrier, preferably as defined herein, in a specific ratio to form a stable complex. In this context, it is highly preferable, that no free5 cationic or polycationic compound or polymeric carrier or only a negligibly small amount thereof remains in the component of the complexed artificial nucleic acid after complexing the artificial nucleic acid. Accordingly, the ratio of the at least one artificial nucleic acid and the cationic or polycationic compound and/or the polymeric carrier in the component of the complexed at least one artificial nucleic acid is typically selected in a range that the at least one artificial nucleic acid is entirely complexed and no free cationic or polycationic compound or polymeric carrier or only a negligibly small amount thereof remains in the composition.0

The inventive composition comprising at least one artificial nucleic acid according to the invention may be provided in liquid and or in dry (e.g. lyophylized) form. In a preferred embodiment, the inventive artificial nucleic acid or the inventive composition is provided in lyophilized form. The inventive artificial nucleic acid and the inventive composition thus provide a possibility to store (irrespective of the ambient temperature and also without cooling) an artificial nucleic acid and a composition suitable for5 vaccination against Norovirus and related diseases or disorders. Preferably, the at least one lyophilized artificial nucleic acid is reconstituted in a suitable buffer, advantageously based on an aqueous carrier, e.g. inger-Lactate solution, prior to use, such as administration to a subject. one embodiment, the composition according to the invention

a) comprises a plurality or more than one of the m NA sequences as defined in the invention;

or

b) comprises at least 2. 3, 4, 5, B, 7, 8, 8, ID, II, I2, 13, 14, I5, IB, I7, 18, 19, ZD, Zl. 22, 23, 24, 25, 2B, 27, 28, 28, 3D, 3I, 32, 33, 34, 35, 3B, 37, 38, 30, 4D, 41, 42. 3, 44, 45, 4B, 47, 48, 43, 5D, 51, 52, 53, 54, 55, 5B, 57, 58, 59, BD, Bl, B2, B3, B4, B5, BB, B7, 68, 69, 7D, 7172, 73, 74, 75, 7B, 77, 78, 79, 80, 81, 82, 83, 84, 85, 8B, 87, 88, 89, 9D, 91, 92, 93, 94, 95, 96, 97, 98, 99, IDO or more artificial nucleic acids as defined in the invention, wherein each of the at least 2, 3, 4, 5, B, 7, 8. 9, ID, II, 12, 13, 14, 15, IB.17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 42, 43, 44. 45.46, 47, 8, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, Bl, 62, 63, B4, B5, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85. 86. 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising a Norovirus protein as defined in the invention, and/or a fragment or a variant of any one of these proteins, wherein each coding region preferably encodes a different Norovirus protein, more preferably each coding region encodes a capsid protein, preferably VPI of a different Norovirus.

In another embodiment, the composition according to the invention comprises at least 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, IB,D 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52.

53, 54, 55, 5B, 57. 58, 59, B0, 61, 62, 63, 64, B5, BB, B7, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95. 96, 97, 98, 99, 10D or more artificial nucleic acids of the invention, wherein each of the at least 2, 3.4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21. 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34. 35, 36, 37, 38, 39, 0, 41, 42, 43.44.45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 58, 60, 61, 62, 63, 64.65, 6B. B7. 68. 69, 70, 71, 72, 73, 74, 75, 76,5 77, 78, 79, 80, 81, 82, 83, 84, 85, SB, 87, 88, 89, 90, 81, 92, 93, 94, 95, 96, 97, 98, 99, IDO or more artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising at least two different Norovirus proteins, preferably VPI and VP2, as defined in the invention, and/or a fragment or a variant of any one of these proteins, and/or wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from proteins of the same Norovirus.

D

In a further embodiment, the composition according to the invention comprises mRNA sequences, wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from different proteins of the same Norovirus.

In a further embodiment, the composition according to the invention comprises mRNA sequences, wherein each of the mRNA5 sequences encodes at least one different antigenic peptide or protein derived from different proteins of different Noroviruses. In a further aspect, the invention concerns a vaccine comprising the artificial nucleic acid as described herein or the inventive composition comprising at least one artificial nucleic acid according to the invention. Therein, the at least one artificial nucleic acid preferably elicits an adaptive immune response upon administration to a subject.

5 In a preferred embodiment, the inventive vaccine comprises the artificial nucleic acid as described herein or the inventive composition comprising at least one artificial nucleic acid according to the invention and a pharmaceutically acceptable carrier. Accordingly, the inventive vaccine is based on the same components as the inventive composition comprising at least one artificial nucleic acid according to the invention as defined above. Insofar, it may be referred to the above disclosure defining the inventive composition.

I0

In one embodiment, the composition of the invention comprises a plurality or more than one of the mRNA sequences of the invention.

In one embodiment, the composition of the invention comprises a plurality or more than one of the mRNA sequences of the I5 invention, wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from proteins of the same Norovirus.

In one embodiment, the composition of the invention comprises a plurality or more than one of the mRNA sequences of the invention, wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from differentD proteins of the same Norovirus.

In another embodiment, the composition of the invention comprises a plurality or more than one of the mRNA sequences of the invention, wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from different proteins of different Noroviruses.

5

In one embodiment, the vaccine of the invention is multivalent and comprises

(i) at least 2, 3, 4, 5, B, 7, 8, 9, ID or more artificial nucleic acids of the invention: or

(ii) at least ID, I5, 2D or 5D artificial nucleic acids of the invention; or

(iii) 2-ID, ID-I5, 15-20, 2D-5D, 50-100 or ID0-2D0 artificial nucleic acids of the invention.

D

in a further embodiment of the invention, the artificial nucleic acids of the vaccine of the invention

(i) are derived from a single Gl Norovirus or from 2, 3, 4, 5, 6.7, 8, 3, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 4D, 41, 42, 3, 44, 45, 4B, 47, 8, 49, 50. 51, 52, 53, 54, 55, 5B, 57, 58, 59, BD, Bl, B2, B3, B4, B5, BB, B7, B8, 69, 70, 71, 72, 73, 74, 75, 7B, 77, 78, 79, 80, 81, 82, 83, 84, 85, 8B, 87, 88, 89,5 90, 91, 92, 93, 94, 95. 9B, 97, 98, 99, 100 or more different Gl Noroviruses; or (ii) are derived from a single Gil Norovirus or from 2, 3, , 5, B, 7, 8. 9, 10, II. I2.13, 14, I5, IB. I7, 18.19, 20, 21.22.23, 24, 25, 2B.27, 28, 29, 30, 31. 32, 33, 34, 35, 3B, 37, 38, 39.40.41. 42, 43, 44, 45, B, 47, 48, 49, 50, 51, 52, 53, 54, 55, 5B, 57, 58, 59. GO, Bl. B2. B3, B4. B5, BB, B7, G8, B9, 70, 71, 72, 73, 74, 75, 7B, 77, 78, 79, 80. 81. 82, 83, 84, 85, 8B, 87, 88, 89, 90, 91, 92, 93, 94, 95, 9B, 97, 98, 99.100 or more different Gil Noroviruses; or

(iii) are derived from a single Gill Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, B, 27, 28, 29. 30, 31, 32, 33, 34, 35, 3B. 37, 38, 39, 4D, 41, 42, 43, 44, 45, 4B, 47, 48, 49, 50, 51, 52, 53. 54. 55, 5B. 57, 58, 59, B0, Bl, B2, B3, B4, B5, BB, B7, B8, B9, 70, 71, 72, 73, 74, 75, 7B, 77, 78, 79, 8D, 81, 82, 83, 84, 85, 8B, 87, 88, 89, 90, 91, 92, 93, 94, 95, 9B, 97, 98, 90, 100 or more different Gill Noroviruses; or

(iv) are derived from a single GIV Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14. 15. IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 1, 42, 43, 44, 45, 4B, 47, 48, 49, 50, 51, 52, 53, 54, 55, 5B,

57. 58. 59, B0, Bl, 62, B3, B4, B5, BB, 67, 68, 69, 70, 71.72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88,

89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different GIV Noroviruses; or

(v) are derived from a single GV Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25.

2B, 27, 28, 29. 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 1, 42, 43, 44, 45.4B, 47, 48, 49, 50, 51. 52. 53, 54, 55, 5B, 57. 58, 59. B0, Bl, B2, 63, G4, B5. B6, 67, B8, B9.70.71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 8B, 87, 88, 89,

90, 91, 92. 93. 94, 95, 96. 97, 98, 99, 100 or more different GV Noroviruses; or

(vi) are derived from a single Gl Norovirus and additionally from a single Gil Norovirus, Gill Norovirus, GIV Norovirus and/ or GV Norovirus; or

(vii) are derived from a single Gl Norovirus or from 2, 3.4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32.33. 34, 35, 3B, 37. 38. 39, 40, 41, 2, 3, 44, 45, 46, 47, 48, 9, 50, 51. 52, 53, 54, 55, 56. 57.

58.59. 60, Bl, B2, 63, B4, B5, BB, B7, 68, 69, 7D, 71, 72.73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88. 89.

90. 91, 92, 93. 94, 95, 96, 97, 98, 99, 100 or more different Gl Noroviruses and additionally from a single Gil, Gill, GIV and/or GV Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13. 14. 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60. 61, B2, B3, B4, B5, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80. 81. 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93,

94, 95, 96, 97, 98, 99, 100 or more Gil, Gill, GIV and/or GV Noroviruses.

In another embodiment of the invention, the artificial nucleic acids of the vaccine of the invention

(i) are derived from a single Gl.l Norovirus or from 2, 3, , 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35. 36. 37, 38, 39, 40, 41, 42, 43, 4, 45, 4B, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56,

57. 58, 59. 60, Bl, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100 or more different Gl.l Noroviruses; nr

(ii) are derived from a single GII.4 Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27. 28, 29, 30, 31, 32. 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 3, 44.45.46.47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59. GO, Bl, B2, 63. B4, 65, BB, B7, 68. 69. 70, 71, 72, 73, 74, 75, 76, 77, 78.79. 8D, 81, 82, 83, 84, 85, 8B, 87, 88,

89, 90, 91, 92, 93, 94, 95, 06, 97, 98, 99, 100 or more different GII.4 Noroviruses; or (iii) are derived from a single Gl.l Norovirus and additionally from a single GII.4 Norovirus; or

(iv) are derived from a single Gl.l Norovirus or from 2, 3.4, 5. G, 7, 8, 9, 10, II. I2, 13. 14. 15, IB, I7, 18, IB, 20, 2I, 22, 23. 24, 25, 26, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3G, 37, 38, 39, 4D, 41, 42, 43, 44. 45.46, 47, 48, 49, 5D, 51 52, 53, 54. 55, 56, 57, 58, 59, 6D, 61, 62. 63, 64, 65. 66, 67, 68, 69.7D. 71, 72.73.74, 75, 76, 77, 78, 70, 8D. 81, 82, 83, 84, 85, 86, 87, 88, 89, 9D, 91, 92, 93, 94, 95, 96, 97. 98, 99, IDO or more different Gl.l Nnroviruses and additionally from a single GII.4 Norovirus or from 2, 3, 4, 5, 6, 7. 8, 9, ID, II, 12, 13, 14. 15, 16, 17, 18, 19, 2D, 21, 22, 23, 24, 25, 26, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 36. 37, 38, 39, 4D, 41, 42, 43, 4, 45, 46, 47, 48, 9, 5D, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, B3, 64, 65, 66, 67, 68, 69, 7D.71, 72, 73, 74, 75.76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87. 88, 89, 90. 91, 92.93, 94, 95. 96, 97. 98, 99, 10D or more GII.4 Noroviruses.

As with the composition according to the present invention, the entities of the vaccine may be provided in liquid and or in dry (e.g. lyophylized) form. They may contain further components, in particular further components allowing for its pharmaceutical use. The inventive vaccine or the inventive composition may, e.g., additionally contain a pharmaceutically acceptable carrier and/or further auxiliary substances and additives and/or adjuvants.

The inventive vaccine or composition typically comprises a safe and effective amount of the inventive artificial nucleic acid as defined herein. As used herein, "safe and effective amount" means an amount of the artificial nucleic acid of the composition or the vaccine as defined above, that is sufficient to significantly induce an immune response against a Norovirus protein. At the same time, however, a "safe and effective amount" is small enough to avoid serious side effects that is to say to permit a sensible relationship between advantage and risk. The determination of these limits typically lies within the scope of sensible medical judgment. In relation to the inventive vaccine or composition, the expression "safe and effective amount" preferably means an amount of the artificial nucleic acid that is suitable for stimulating the adaptive immune system in such a manner that no excessive or damaging immune reactions are achieved but, preferably, also no such immune reactions below a measurable level. Such a "safe and effective amount" of the artificial nucleic acid of the composition or vaccine as defined above may furthermore be selected in dependence of the type of artificial nucleic acid, e.g. monocistronic, bi- or even multicistronic mRNA, since a bi- or even multicistronic mRNA may lead tD a significantly higher expression of the encoded polypeptide(s) than use of an equal amount of a monocistronic mRNA. A "safe and effective amount" of the artificial nucleic acid of the composition or vaccine as defined above may furthermore vary in connection with the particular objective of the treatment and also with the age and physical condition of the patient to be treated, and similar factors, within the knowledge and experience of the accompanying doctor. The vaccine or composition according to the invention can be used according to the invention for human and also for veterinary medical purposes, as a pharmaceutical composition or as a vaccine.

In a preferred embodiment, the artificial nucleic acid of the composition, vaccine or kit of parts according to the invention is provided in lyophilized form. Preferably, the lyophilized artificial nucleic acid is reconstituted in a suitable buffer, advantageously based on an aqueous carrier, prior to administration, e.g. Ringer-Lactate solution, which is preferred. Ringer solution, a phosphate buffer solution. According to a preferred embodiment, the buffer suitable for injection may be used as a carrier in tbe inventive vaccine or composition or for resuspending the inventive vaccine or the inventive composition. Such a buffer suitable for injection may contain salts selected from sodium chloride (NaCI). calcium chloride (CaCb) and optionally potassium chloride (KCI), wherein further anions may be present additional to the chlorides. CaC can also be replaced by another salt like KCI. Typically, the salts in the injection buffer are present in a concentration of at least 50 mM sodium chloride (NaCI), at least 3 mM potassium chloride (KCI) and at least 0,01 mM calcium chloride (CaC ). The injection buffer may be hypertonic, isotonic or hypotonic with reference to the specific reference medium, i.e. the buffer may have a higher, identical or lower salt content with reference to the specific reference medium, wherein preferably such concentrations of the afore mentioned salts may be used, which do not lead to damage of cells due to osmosis or other concentration effects. Reference media are e.g. in "in vivo" methods occurring liquids such as blood, lymph, cytosolic liquids, or other body liquids, or e.g. liquids, which may be used as reference media in "in vitro" methods, such as common buffers or liquids. Such common buffers Dr liquids are known to a skilled person. Ringer-Lactate solution is particularly preferred as a liquid basis. The choice of a pharmaceutically acceptable carrier is determined, in principle, by the manner, in which the inventive vaccine or the inventive composition is administered. The inventive vaccine or composition can be administered, for example, systemically or locally. Routes for systemic administration in general include, for example, transdermal, oral, parenteral routes, including subcutaneous, intravenous, intramuscular, intraarterial, intradermal and intraperitoneal injections and/or intranasal administration routes. Routes for local administration in general include, for example, topical administration routes but also intradermal, transdermal, subcutaneous, or intramuscular injections or intralesional, intracranial, intrapulmonal, intracardial, and sublingual injections. More preferably, the inventive vaccine or the inventive composition may be administered by an intradermal, subcutaneous, or intramuscular route, preferably by injection, which may be needle-free and/or needle injection. Compositions/vaccines are therefore preferably formulated in liquid or solid form. The suitable amount of the inventive vaccine or composition to be administered can be determined by routine experiments with animal models. Such models include, without implying any limitation, rabbit, sheep, mouse, rat, dog and non-human primate models. Preferred unit dose forms for injection include sterile solutions of water, physiological saline or mixtures thereof. The pH of such solutions should be adjusted to about 7.4. Suitable carriers for injection include hydrogels, devices for controlled or delayed release, polylactic acid and collagen matrices. Suitable pharmaceutically acceptable carriers for topical application include those which are suitable for use in lotions, creams, gels and the like. If the inventive vaccine is to be administered perorally, tablets, capsules and the like are the preferred unit dose form. The pharmaceutically acceptable carriers for the preparation of unit dose forms which can be used for oral administration are well known in the prior art. The choice thereof will depend on secondary considerations such as taste, costs and storability, which are not critical for the purposes of the present invention, and can be made withoot difficulty by a person skilled in the art. Adjuvants:

According to another embodiment, the inventive (pharmaceutical) composition or the inventive vaccine may comprise an adjuvant. An adjuvant may be used, for example, in order to enhance the immunostimulatory properties of the vaccine or composition. In this context, an adjuvant may be understood as any compound, which is suitable to support administration and

5 delivery of the vaccine or composition according to the invention. Furthermore, such an adjuvant may, without being bound thereto, initiate or increase an immune response of the innate immune system, i.e. a nan-specific immune response. In other words, when administered, the vaccine or composition according to the invention typically initiates an adaptive immune response due to the at least one polypeptide encoded by the artificial nucleic acid contained in the inventive vaccine or composition. Additionally, the vaccine or composition according to the invention may generate an (supportive) innate immune response due

ID to addition of an adjuvant as defined herein to the vaccine or composition according to the invention.

In one embodiment, the adjuvant is selected from the group consisting of:

cationic or polycationic compounds, comprising cationic or polycationic peptides or proteins, including protamine, nucleoline, spermin or spermidine, poly-L-lysine (PLL), poly-arginine, basic polypeptides, cell penetrating peptides (CPPs), including HIV-

I5 binding peptides, Tat, HIV-I Tat (HIV), Tat-derived peptides, Penetratin, VP22 derived or analog peptides, HSV VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpTFJ20, proline-rich peptides, arginine-rich peptides, lysine-rich peptides, MPG-peptide(s), Pep-I, L-oligomers, Calcitonin peptide(s), Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, plsl, FGF, Lactoferrin, Transportan, Buforin-2, FJac7l5-24, SynB, SynB(l), pVEC, hCT-derived peptides, SAP, protamine, spermine, spermidine, or histones, cationic polysaccharides, including chitosan, polybrene, cationic polymers,D including polyethyleneimine (PEI), cationic lipids, including DOTMA: [l-(2,3-sioleyloxy)propyl)]-N,N,N-trimethylammonium chloride, DM IE, di-CI4-amidine. DDTIM. SAINT, DC-Choi, BGTC, CTAP, DDPC. DDDAP, DOPE Dioleyl phosphatidylethanol-amine. DDSPA, DDDAB, DDIC, DMEPC, DOGS: Dioetadecylamidoglicylspermin, DIMRI: Dimyristo-oxypropyl dimethyl hydroxyethyl ammonium bromide, DDTAP: dioleoyloxy-3-(trimethylammonio)propane, DC-G-I4: 0,D-ditetradecanoyl-N-(a- trimethylammoniaacetyljdiethanolamine chloride, CLIPI: rac-[(2,3-dioctadecyloxypropyl)(2-hydroxyethyl)]-dimethylamm onium5 chloride, CLIPS: rac-[2(2,3-dihexadecyloxypropyl-oxymethyloxy)ethyl]-trimethy lammanium, CLIPFJ: rac-[2(2,3- dihexadEcyloxypropyl-oxysuccinyloxy)ethyl]-trimethylammonium . oligofectamine, or cationic or polycationic polymers, including modified polyaminoacids, including β-aminoacid-polymers or reversed polyamides, modified polyethylenes, including PVP (poly(N-ethyl-4-vinylpyridinium bromide)), modified acrylates, including pDMAEMA (poly(dimethylaminoethyl methylacrylate)), modified Amidaamines including pAMAM (poly(amidoamine)), modified polybetaaminoester (PBAE), including diamine end modifiedD l,4 butanediol diacrylate-co-5-amino-l-pentanol polymers, dendrimers, including polypropylamine dendrimers or pAMAM based dendrimers, polyimine(s), including PEI: poly(ethyleneimine), poly(propyleneimine), polyallylamine, sugar backbone based polymers, including cyclodextrin based polymers, dextran based polymers, Chitosan, etc., silan backbone based polymers , such as PMDXA-PDMS copolymers, etc., block polymers consisting of a combination of one or more cationic blocks selected from a cationic polymer as mentioned before, and of one or more hydrophilic- or hydrophobic blocks (e.g polyethyleneglycole);

5 or cationic or polycationic proteins or peptides, selected from the following proteins or peptides having the following total formula (III): (Arg)l;(Lys)m;(His)n;(Orn)o;(Xaa)x, wherein l + m + n +o + x = 8-I5, and I, m, n or o independently of each other may be any number selected from D. I, 2, 3, 4, 5, G, 7, 8, 9, ID, II, I2, 13, 14 or I5, provided that the overall content of Arg, Lys, His and Drn represents at least 5D% of all amino acids of the oligopeptide: and Xaa may be any amino acid selected from native (= naturally occurring) or non-native amino acids except from Arg, Lys, His or Drn; and x may be any number selected from D, I, 2, 3 or 4, provided, that the overall content of Xaa does not exceed 50% of all amino acids of the oligopeptide; or

nucleic acids having the formula (V): GIXmGn, wherein: G is guanosine, uracil or an analogue of guanosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above-mentioned nucleotides; I is an integer from I to 4D, wherein, when I = I G is guanosine or an analogue thereof, when I > I at least 50% of the nucleotides are guanosine or an analogue thereof; m is an integer and is at least 3; wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur; n is an integer from I to 40, wherein when n = I G is guanosine or an analogue thereof, when n > I at least 50% of the nucleotides are guanosine or an analogue thereof;

or

nucleic acids having the formula (VI): ClXmCn, wherein: C is cytosine, uracil or an analogue of cytosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above-mentioned nucleotides; I is an integer from I to 40, wherein when I = I C is cytosine or an analogue thereof, when I > I at least 50% of the nucleotides are cytosine or an analogue thereof; m is an integer and is at least 3; wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur; n is an integer from I to 40, wherein when n = I C is cytosine or an analogue thereof, when n > I at least 50% of the nucleotides are cytosine or an analogue thereof;

or

adjuvants selected from the group consisting of:

TDM, DP. muramyl dipeptide, pluronics, alum solution, aluminium hydroxide, ADJUMER™ (polyphosphazene); aluminium phosphate gel; glucans from algae; algammulin; aluminium hydroxide gel (alum); highly protein-adsorbing aluminium hydroxide gel; low viscosity aluminium hydroxide gel; AF or SPT (emulsion of squalane (5%), Tween 8D (0.2%), Pluronic LI2I (1.25%), phosphate-buffered saline, pH 7.4); AVRID1NE™ (propanediamine); BAY I005™ ((N-(2-deoxy-2-L-leucylamino-b-D- glucopyranosyl)-N-octadecyl-dodecanoyl-amide hydroacetate); CALCITRIOL™ (l-alpha,25-dihydroxy-vitamin 03); calcium phosphate gel; CAP™ (calcium phosphate nanoparticles); cholera holotoxin, cholera-toxin-AI-prDtein-A-D-fragment fusion protein, sub-unit B of the cholera toxin; CRL 1005 (block copolymer PI205); cytokine-containing liposomes; DDA (dimethyldioctadecylammonium bromide); DHEA (dehydroepiandrosterone); 0MPC (dimyristoylphosphatidylcholine); DMPG (dimyristoylphosphatidylglycerol); OOC/alum complex (deoxycholic acid sodium salt); Freund's complete adjuvant; Freund's incomplete adjuvant; gamma inulin; Gerbu adjuvant (mixture of: i) N-acetylglucosaminyl-(PI-4)-N-acetylmuramyl-L-alanyl-D- glutamine (GM0P), ii) dimethyldioctadecylammonium chloride (DDA), iii) zinc-L-proline salt complex (ZnPro-8); GM-CSF); GMDP (N-acetylglucosaminyl-(bl-4)-N-acetylmuramyl-L-alanyl-D-isog lutamine); imiquimod (l-(2-methypropyl)-IH-imidazo[4,5- c]quinoline-4-amine); ImmTher™ (N-acetylglucosaminyl-N-acetylmuramyl-L-Ala-D-isoGlu-L-Ala-g lycerol dipalmitate); DRVs (immunoliposomes prepared from dehydration-rehydration vesicles); interferon-gamma; interleukin-lbeta; interleukin-2; interleukin-7; interleukin-12; ISCOMSTM; ISCDPREP 7.0.3.TM; liposomes; L0XDRIBINE™ (7-allyl-8-oxoguanosine); LT oral adjuvant (E.coli labile enterotoxin-protoxin); microspheres and microparticles of any composition; MF59TM; (squalene-water emulsion); MDNTANIDE ISA 5ί ^Μ (purified incomplete Freund's adjuvant); MDNTANIDE ISA 720™ (metabolisable oil adjuvant); MPL™ (3-Q- desacyl-4'-monophospharyl lipid A); TP-PE and MTP-PE liposomes ((N-aeetyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(l,2- dipalmitoyl-sn-glycero-3-(hydroxyphasphoryloxy))-ethylamide, monosodium salt): MURAMETIDE™ (Nac-Mur-L-Ala-D-Gln-0CH3); MU APALMITINE™ and D-MURAPALMITINE™ (Nac-Mur-L-Thr-D-isoGln-sn-glyceroldipalmitoyl); NAGO (neuraminidase-galactose oxidase); nanospheres or nanoparticles of any composition; NISVs (non-ionic surfactant vesicles); PLEURAN™ (β-glucan); PLGA, PGA and PLA (homo- and co-polymers of lactic acid and glycolic acid; microspheres/nanospheres); PLORONIC LI2ITM; PMMA (polymethyl methacrylate); PODDS™ (proteinoid microspheres); polyethylene carbamate derivatives; poly-rA: poly-rU (polyadenylic acid-polyuridylic acid complex); polysorbate 80 (Tween 80); protein cochleates (Avanti Polar Lipids, Inc., Alabaster, AL); STIMOLON™ (QS-2I): Duil-A (Quil-A saponin); S-284G3 (4-amino-otec-dimethyl-2-ethnxymethyl-IH-imidazo[4,5 c]quinoline-l- ethanol); SAF-I™ ("Syntex adjuvant formulation"); Sendai proteoliposomes and Sendai-containing lipid matrices; Span-85 (sorbitan trioleate); Specol (emulsion of Marcol 52, Span 85 and Tween 85); squalene or Robane ¹ (2,6,10.15.19.23- hexamethyltetracosan and 2,G.I0,l5.l9,23-hexamethyl-2,B,l0J4,l8,22-tetracosahexane); stearyltyrosine (octadecyltyrosine hydrochloride); Therarnid ^B (N-acetylglucosaminyl-N-acetylmuramyl-L-Ala-D-isoGlu-L-Ala-d ipalmitoxypropylamide); Theronyl- MDP (Termurtide™ or [thr l]-MDP; N-acetylmuramyl-L-threonyl-D-isoglutamine); Ty particles (Ty-VLPs or virus-like particles); Walter-Reed liposomes (liposomes containing lipid A adsorbed on aluminium hydroxide), and lipopeptides, including Pam3Cys, in particular aluminium salts, such as Adju-phos, Alhydrogel, Rehydragel; emulsions, including GFA, SAF, IFA, MF59, Provax, TiterMax, Montanide, Vaxfectin; copolymers, including Optivax (CRLI005), LI2I, Polaaxmer40IO), etc.; liposomes, including Stealth, cochleates, including BIORAL; plant derived adjuvants, including QS2I, Qui) A, Iscomatrix, ISCOM; adjuvants suitable for costimulation including Tomatine, biopolymers, including PLG, PMM, Inulin; microbe derived adjuvants, including Romurtide, DETDX, MPL, CWS, Mannose, CpG nucleic acid sequences, CpG7909, ligands of human TLR 1-10, ligands of murine TLR 1-13, ISS-I0I8, IC3I, Imidazoquinolines, Ampligen, Ribi529, IMOxine, IRIVs, VLPs, cholera toxin, heat-labile toxin, Pam3Cys. Flagellin, GPI anchor, LNFPIII/Lewis X, antimicrobial peptides, UC-IVI50. RSV fusion protein, cdiGMP; and adjuvants suitable as antagonists including GGRP neuropeptide.

Particularly preferred are aluminium salts, such as aluminium phosphate (AIPO-s) or aluminium hydroxide (AI(OH)s) and adjuvant compounds based thereon. More preferably, an aluminium salt, such as AIP0/ _t (e.g. Adju-Phos) may be used in combination with the inventive artificial nucleic acid in its free form or with the inventive artificial nucleic acid complexed with a cationic or polycationic compound as described herein. Most preferably, an aluminium salt, such as AlPOi (e.g. Adju-Phos) may be used as adjuvant in combination with the inventive artificial nucleic acid in its free form.

Suitable adjuvants may also be selected from cationic or polycationic compounds, preferably as described herein, wherein the adjuvant is preferably prepared upon complexing the at least one artificial nucleic acid of the inventive composition or vaccine with the cationic or polycationic compound. Association or complexing the artificial nucleic acid with cationic or polycationic compounds as defined herein preferably provides adjuvant properties and confers a stabilizing effect to the artificial nucleic acid. The ratio of the artificial nucleic acid to the cationic or polycationic compound in the adjuvant component may be calculated on the basis of the nitrogen/phosphate ratio (N/P-ratio) of the entire artificial nucleic acid complex, i.e. the ratio of positively charged (nitrogen) atoms of the cationic or polycationic compound to the negatively charged phosphate atoms of the nucleic

5 acids. For example, I pg RNA typically contains about 3 nmnl phosphate residues, provided the RNA exhibits a statistical distribution of bases. Additionally, I pg peptide typically contains about x nmol nitrogen residues, dependent on the molecular weight and the number of basic amino acids. When exemplarily calculated for (Arg)g (molecular weight I424 g/mol, FJ nitrogen atoms), I pg (Arg)a contains about 70D pmol (Arg)g and thus 7D0 x 9=6300 pmol basic amino acids = FJ.3 nmol nitrogen atoms. For a mass ratio of about l:l RNA/(Arg)9 an N/P ratio of about 2 can be calculated. When exemplarily calculated for protamine

I0 (molecular weight about 4250 g/ mol, 2I nitrogen atoms, when protamine from salmon is used) with a mass ratio of about 2:l with 2 pg RNA, FJ nmol phosphate are to be calulated for the RNA; I pg protamine contains about 235 pmol protamine molecues and thus 235 x 2I = 4935 pmol basic nitrogen atoms = 4.9 nmol nitrogen atoms. For a mass ratio of about 2:l RNA/protamine an N/P ratio of about 0.8I can be calculated. For a mass ratio of about 8:l RNA/protamine an N/P ratio of about 0.2 can be calculated. In the context of the present invention, an N/P-ratio is preferably in the range of about 0.I-I0, preferably in a range of about 0.3-

I5 4 and most preferably in a range of about 0.5-2 or 0.7-2 regarding the ratio of nucleic acid:peptide in the complex, and most preferably in the range of about 0.7-I.5.

In a preferred embodiment, the inventive vaccine or the inventive composition is obtained in two separate steps in order to obtain both, an efficient immunostimulatory effect and efficient translation of the artificial nucleic acid according to the invention.0 Therein, a so called "adjuvant component" is prepared by complexing - in a first step - a nucleic acid, preferably an RNA, of the adjuvant component with a cationic or polycationic compound in a specific ratio to form a stable complex. In this context, it is important, that no free cationic or polycationic compound or only a neglibly small amount remains in the adjuvant component after complexing the nucleic acid. Accordingly, the ratio of the nucleic acid, preferably an RNA, and the cationic or polycationic compound in the adjuvant component is typically selected in a range that the artificial nucleic acid is entirely cDmplexed and no5 free cationic or polycationic compound or only a neglectably small amount remains in the composition. Preferably the ratio of the adjuvant component, i.e. the ratio of the artificial nucleic acid to the cationic or polycationic compound is selected from a range of about B:l (w/w) to about 0,25:1 (w/w), more preferably from about 5:1 (w/w) to about 0,5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w).

0

According to a preferred embodiment, the artificial nucleic acid, preferably an mRNA, is added in a second step to the complexed nucleic acid, preferably an RNA, of the adjuvant component in order to form the (immunostimulatory) composition of the invention. Therein, the artificial nucleic acid is added as free nucleic acid, i.e. nucleic acid, which is not complexed by Dther compounds. Prior to addition, the free artificial nucleic acid is not complexed and will preferably not undergo any detectable or significant5 complexation reaction upon the addition of the adjuvant component. This is due to the strong binding of the cationic or polycationic compound to the above described artificial nucleic acid in the adjuvant component. In other words, when the artificial nucleic acid according to the invention, is added to the "adjuvant component", preferably no free or substantially no free cationic or polycationic compound is present, which may form a complex with the free artificial nucleic acid. Accordingly, an efficient translation of the free artificial nucleic acid of the inventive vaccine or composition is possible in vivo. Therein, the free artificial nucleic acid may occur, for example, as a mono-, di-, or multicistronic nucleic acid, i.e. an artificial nucleic acid which carries 5 the coding sequences of Dne or more polypeptides. Such coding sequences in a di-, or even multicistronic nucleic acid may be separated by at least one IRES sequence, e.g. as defined herein.

In a particularly preferred embodiment, the free artificial nucleic acid, which is comprised in the inventive vaccine or composition, may be identical or different to the RNA of the adjuvant component of the inventive composition, depending on the specific I0 requirements of therapy. Even more preferably, the artificial nucleic acid, preferably an mRNA, which is comprised in the inventive vaccine or composition, is identical to the RNA of the adjuvant component of the inventive vaccine or composition.

In a particularly preferred embodiment, the composition comprises the artificial nucleic acid, preferably an mRNA, wherein said artificial nucleic acid is present in the composition partially as free nucleic acid and partially as complexed nucleic acid. I5 Preferably, the artificial nucleic acid, preferably an mRNA, is complexed as described above and the same artificial nucleic acid is then added as free nucleic acid, wherein preferably the compound, which is used for complexing the artificial nucleic acid is not present in free form in the composition at the moment of addition of the free nucleic acid component.

The ratio of the first component (i.e. the adjuvant component comprising or consisting of artificial nucleic acid complexed with a0 cationic or polycationic compaund) and the second component (i.e. the free nucleic acid) may be selected in the inventive composition according to the specific requirements of a particular therapy. Typically, the ratio of the nucleic acid, preferably an RNA, in the adjuvant component and the at least one free artificial nucleic acid, preferably an mRNA, (artificial nucleic acid, preferably mRNA in the adjuvant component : free RNA) of the inventive composition is selected such that a significant stimulation of the innate immune system is elicited due to the adjuvant component. In parallel, the ratio is selected such that a significant5 amount of the at least one free artificial nucleic acid, preferably an mRNA, can be provided in vivo leading to an efficient translation and concentration of the expressed protein in vivo, e.g. the at least Dne encoded polypeptide as defined herein. Preferably, the ratio of the mRNA in the adjuvant component : free mRNA in the inventive composition is selected from a range of about 5:l (w/ w) to about l:ID (w/ w), more preferably from a range of about 4:l (w/w) to about l:8 (w/ w), even more preferably from a range of about 3:l (w/ w) to about l:5 (w/ w) or l:3 (w/ w), and most preferably the ratio of mRNA in the adjuvant componentD : free mRNA in the inventive composition is selected from a ratio of about l:l (w/w).

Additionally or alternatively, the ratio of the first component (i.e. the adjuvant component comprising or consisting of artificial nucleic acid complexed with a cationic or polycationic compound) and the second component (i.e. free artificial nucleic acid) may be calculated on the basis of the nitrogen/ phosphate ratio (N/P-ratio) of the entire mRNA complex. In the context of the present5 invention, an N/P-ratio is preferably in the range of about O.I-ID, preferably in a range of about 0.3-4 and most preferably in a range of about 0.5-2 or 0.7-2 regarding the ratio of mRNA:peptide in the complex, and most preferably in the range of about 0.7- I.5.

Additionally or alternatively, the ratio of the first component (i.e. the adjuvant component comprising or consisting of artificial nucleic acid, preferably mRNA, complexed with a cationic or polycationic compound) and the second component (i.e. free artificial nucleic acid, preferably mRNA) may also be selected in the inventive composition on the basis of the molar ratio of both nucleic acids to each other, i.e. the nucleic acid of the adjuvant component, being complexed with a cationic or polycationic compound and the free nucleic acid of the second component. Typically, the molar ratio of the nucleic acid of the adjuvant component to the free nucleic acid of the second component may be selected such, that the molar ratio suffices the above (w/w) and/or N/P- definitions. More preferably, the molar ratio of the nucleic acid, preferably an mRNA, of the adjuvant component to the free nucleic acid, preferably an mRNA, of the second component may be selected e.g. from a molar ratio of about 0.00l:l, 0.01:1. 0.1:1, 0.2:1, 0.3:1, 0.4:1. 0.5.1, 0.G-.I. 0.7:1, 0.8:1, 0.9:1, 1:1, 1:0.9. 1:0.8, 1:0.7. 1:0.6. 1:0.5, 1:0.4. 1:0.3, 1:0.2, 1:0.1, 1:0.01, 1:0.001, etc. or from any range formed by any two of the above values, e.g. a range selected from about 0.001:1 to 1:0.001, including a range of about 0.01:1 to 1:0.001, 0.1:1 to 1:0.001, 0.2:1 to 1:0.001, 0.3:1 to 1:0.001, 0,4:1 to 1:0.001, 0.5:1 to 1:0.001, 0.G:l to 1:0.001, 0.7:1 to 1:0.001, 0.8:1 to 1:0.001, D.9:l to 1:0.001, 1:1 to 1:0.001, 1:0.9 to 1:0.001, 1:0.8 to 1:0.001, 1:0.7 to 1:0.001, 1:0.6 to 1:0.001, 1:0.5 to 1:0.001, 1:0.4 to 1:0.001, 1:0.3 to 1:0.001, 1:0.2 to 1:0.001, 1:0.1 to 1:0.001, 1:0.01 to 1:0.001, or a range of about 0.01:1 to 1:0.01, 0.1:1 to 1:0.01, 0.2:1 to 1:0.01, 0.3:1 to 1:0.01. 0.4:1 to 1:0.01, 0.5:1 to 1:0.01, 0.6:1 to 1:0.01, 0.7:1 to 1:0.01, 0.8:1 to 1:0.01, 0.9:1 to 1:0.01, 1:1 to 1:0.01, 1:0.9 to 1:0.01, 1:0.8 to 1:0.01.1:0.7 to 1:0.01.1:0.6 to 1:0.01, 1:0.5 to 1:0.01, 1:0.4 to 1:0.01, 1:0.3 to 1:0.01, 1:0.2 to 1:0.01, 1:0.1 to 1:0.01, 1:0.01 to 1:0.01, or including a range of about 0.001:1 to 1:0.01, 0.001:1 to 1:0.1. 0.001:1 to 1:0.2, 0.001:1 to 1:0.3, 0.001:1 to 1:0.4. 0.001:1 to 1:0.5, 0.001:1 to 1:0.6. 0.001:1 to 1:0.7, 0.001:1 to 1:0.8, 0.001:1 to 1:0.9, 0.001:1 to 1:1. 0.001 to 0.9:1, 0.001 to 0.8:1, 0.001 to 0.7:1, 0.001 to 0.6:1, 0.001 to 0.5:1. D.00I to 0.4:1, 0.001 to 0.3:1, 0.001 to 0.2:1, 0.001 to 0.1:1, or a range of about 0.01:1 to 1:0.01, 0.01:1 to 1:0.1, 0.01:1 to 1:0.2, 0.01:1 to 1:0.3, 0.01:1 to 1:0.4, 0.01:1 to 1:0.5, 0.01:1 to 1:0.6, 0.01:1 to 1:0.7, 0.01:1 to 1:0.8, 0.01:1 to 1:0.9, 0.01:1 to 1:1, 0.001 to 0.9:1, 0.001 to 0.8:1, 0.001 to 0.7:1, 0.001 to 0.6:1, 0.001 to 0.5:1, 0.001 to 0.4:1, 0.001 to 0.3:1, 0.001 to 0.2:1, 0.001 to 0.1:1. etc. Even more preferably, the molar ratio of the artificial nucleic acid, preferably an mRNA, of the adjuvant component to the free nucleic acid, preferably an mRNA, of the second component may be selected e.g. from a range of about 0.01:1 to 1:0.01. Most preferably, the molar ratio of the nucleic acid of the adjuvant component to the free nucleic acid of the second component may be selected e.g. from a mnlar ratio of about 1:1. Any of the above definitions with regard to (w/w) and/or N/P ratio may also apply.

Suitable adjuvants may furthermore be selected from nucleic acids having the formula (V): GiX _m G _n , wherein: G is goanosine, uracil or an analogue of guanosine or uracil: X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above- mentioned nucleotides: I is an integer from I to 40, wherein when I = I G is guanosine or an analogue thereof, when I > I at least 50% of the nucleotides are guanosine or an analogue thereof: m is an integer and is at least 3: wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur: n is an integer from I to 40, wherein when n = I G is guanosine or an analogue thereof, when n > I at least 50% of the nucleotides are guanosine or an analogue thereof.

Other suitable adjuvants may furthermore be selected from nucleic acids having the formula (VI): CiXmCn, wherein: C is cytosine, 5 uracil or an analogue of cytosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above- mentioned nucleotides; I is an integer from I to 40, wherein when I = I C is cytosine or an analogue thereof, when I > I at least 50% of the nucleotides are cytosine or an analogue thereof; m is an integer and is at least 3: wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur; n is an integer from I to 40, wherein when n = I C is cytosine or an analogue thereof, when n > I at least 50% of the nucleotides are cytosine or an analogue thereof.

I0

The inventive vaccine or composition can additionally contain one or more auxiliary substances in order to further increase the immunogenicity. A synergistic action of the artificial nucleic acid of the composition or vaccine as defined herein and of an auxiliary substance, which may be optionally be co-formulated (or separately formulated) with the inventive vaccine or composition as described above, is preferably achieved thereby. Depending on the various types of auxiliary substances, various

I5 mechanisms can come into consideration in this respect. For example, compounds that permit the maturation of dendritic cells (DCs), for example lipopolysaccharides, TNF-alpha or CD40 ligand, form a first class of suitable auxiliary substances. In general, it is possible to use as auxiliary substance any agent that influences the immune system in the manner of a "danger signal" (LPS, GP9B, etc.) or cytokines, such as GM-CFS, which allow an immune response produced by the immune-stimulating adjuvant according to the invention to be enhanced and/or influenced in a targeted manner. Particularly preferred auxiliary substances0 are cytokines, such as monokines, lymphokines, interleukins or chemokines, that - additional to induction of the adaptive immune response by the encoded at least one antigen - prnmote the innate immune response, such as IL-I, IL-2, IL-3, IL-4, IL-5, IL-B, IL- 7, IL-B. IL-B, IL-I0, IL-IZ. IL-I3, IL-I4, IL-I5, IL-IB. IL-I7. IL-I8, IL-IB, IL-ZD. IL-2I, IL-22, IL-23, IL-24, IL-25, IL-2B. IL-27, IL-28, IL-29, IL-30, IL-3I, IL-32, IL-33, INF-alpha, IFN-beta, INF-gamma, G -CSF, G-CSF, M-CSF, LT-beta or TNF-alpha, growth factors, such as hGH. Preferably, such immunogenicity increasing agents or compounds are provided separately (not co-formulated with the5 inventive vaccine or composition) and administered individually.

The inventive vaccine or composition can also additionally contain any further compound, which is known to be immune- stimulating due to its binding affinity (as ligands) to human Toll-like receptors TL I, TLR2, TLR3, TLR4, TLR5, TLRB, TLR7, TLR8, TLR3, TLRI0, or due to its binding affinity (as ligands) to murine Toll-like receptors TLRI, TLR2, TLR3, TLR4, TLR5, TLRB, TLR7, TLR8,0 TLR9, TLRI0, TLRII, TLRI2 or TLRI3.

Another class of compounds, which may be added to an inventive vaccine or composition in this context, may be CpG nucleic acids, in particular CpG-RNA or CpG-DNA. A CpG-RNA or CpG-DNA can be a single-stranded CpG-DNA (ss CpG-DNA). a double- stranded CpG-DNA (dsDNA), a single-stranded CpG-RNA (ss CpG-RNA) or a double-stranded CpG-RNA (ds CpG-RNA). The CpG5 nucleic acid is preferably in the form of CpG-RNA, more preferably in the form of single-stranded CpG-RNA (ss CpG-RNA). The CpG nucleic acid preferably contains at least one or more (mitogenic) cytosine/guanine dinucleotide sequence(s) (CpG motif(s)). According to a first preferred alternative, at least one CpG motif contained in these sequences, that is to say the C (cytosine) and the G (guanine) of the CpG motif, is unmethylated. All further cytosines or guanines optionally contained in these sequences can be either methylated or unmethylated. According to a further preferred alternative, however, the C (cytosine) and the G (guanine) of the CpG motif can also be present in methylated form.

5

Preferably, the above compounds are formulated and administered separately from the above composition or vaccine (of the invention) containing the artificial nucleic acid according to the invention.

Polypeptide:

ID In a further aspect, the present invention concerns a polypeptide encoded by the inventive artificial nucleic acid as described herein, or a fragment of said polypeptide.

More preferably, the inventive polypeptide comprises or consists of, preferably in this order from N-terminus to C-terminus: a) an amino acid sequence derived from a C-terminal fragment from mature Norovirus capsid protein VPI, or a variant I5 thereof, wherein the C-terminal fragment preferably comprises or consists of 3 to 2D amino acid residues,

b) an amino acid sequence derived from a signal sequence of Norovirus capsid protein VPI, or a fragment or variant thereof, or an amino acid sequence derived from a C-terminal fragment, or a variant thereof, of Norovirus capsid protein VPI as present in Norovirus pulyprotein before cleavage, preferably as described herein. D More preferably, the inventive polypeptide is selected from the group coosisting of Norovirus NSI/NS2, NS3, NS4, NS5, NSG, NS7, VPI, and VP2, or a fragment or variant of any of these proteins, and

at least one amino acid sequence selected from the group consisting of:

a) an amino acid sequence derived from a C-terminal fragment from mature Norovirus capsid protein VPI, or a variant thereof, wherein the C-terminal fragment consists of 3 to 2D amino acid residues,

5 b) an amino acid sequence derived from a signal sequence of Norovirus capsid protein VPI, or a fragment or variant thereof, and

c) an amino acid sequence derived from an N-terminal fragment from mature Norovirus non-structural protein NSI/NS2, NS3, NS4, NS5, NSG, or NS7, or a variant thereof, wherein the N-terminal fragment consists of 3 to 2D amino acid residues.

D

In a preferred embodiment, the inventive polypeptide does not comprise an amino acid sequence from Norovirus capsid protein VPI or from Norovirus non-structural protein I (NSI) distinct from the following amino acid sequences:

a) an amino acid sequence derived from a C-terminal fragment from mature Norovirus capsid protein VPI, or a variant thereof, wherein the C-terminal fragment preferably comprises or consists of 3 to 2D amino acid residues. b) an amine- acid sequence derived fram a signal sequence of Norovirus capsid protein VPI, or a fragment or variant thereof, or an amino acid sequence derived from a C-terminal fragment, or a variant thereof, of Norovirus capsid protein VPI as present in Norovirus polyprotein before cleavage, preferably as described herein, and c) an amino acid sequence derived from an N-terminal fragment from mature Norovirus non-structural protein (NSI). or 5 a variant thereof, wherein the N-terminal fragment preferably comprises or consists of 3 to 20 amino acid residues.

According to a preferred embodiment, the inventive polypeptides as described herein comprises a molecular tag, wherein the molecular tag is selected from the group consisting of a FLAG tag, a glutathiane-S-transferase (GST) tag, a His tag, a Myc tag, an E tag, a Strep tag, a green fluorescent protein (GFP) tag and an HA tag,

ID

In a further aspect, the present invention provides a composition comprising at least one of the inventive polypeptides as described herein. In a preferred embodiment, the inventive composition comprises one type of polypeptide as described herein. Alternatively, the inventive composition may comprise at least two different inventive polypeptides as described herein.

I5 Preferably, the inventive composition comprises or consists of at least one of the inventive polypeptides described herein and a pharmaceutically acceptable carrier. In this context, the pharmaceutically acceptable carrier as well as optional further components of the composition are preferably as described herein with respect to the inventive composition comprising at least one inventive artificial nucleic acid. D In a further aspect, the invention concerns a vaccine comprising the inventive composition comprising at least one of the polypeptides according to the invention. Therein, the at least one of the inventive polypeptides preferably elicits an adaptive immune response upon administration to a subject. More preferably, the vaccine according to the invention comprising at least one of the inventive polypeptides or the inventive composition comprising at least one of the polypeptides according to the invention is preferably a vaccine as described herein. Reference is made to the respective description herein.

5

As used herein, the term 'inventive composition' may refer to the inventive composition comprising at least one artificial nucleic acid according to the invention as well as to the inventive composition comprising at least ooe of the polypeptides according to the invention. Likewise, the term 'inventive vaccine', as used in this context, may refer to an inventive vaccine, which is based on the inventive artificial nucleic acid, i.e. which comprises at least one artificial nucleic acid according to the invention or whichD comprises the inventive composition comprising said artificial nucleic acid, as well as to an inventive vaccine, which is based on the inventive polypeptide(s), i.e. which comprises at least one polypeptide according to the invention or which comprises the inventive composition comprising said at least one polypeptide according to the invention.

According to another embodiment, the present invention also provides kits, particularly kits of parts, comprising the artificial5 nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide or the inventive vaccine as described herein, optionally a liquid vehicle for solubilising and optionally technical instructions with information on the administration and dosage of the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide or the inventive vaccine. The technical instructions

5 may contain information about administration and dosage. Such kits, preferably kits of parts, may be applied e.g. for any of the applications or uses mentioned herein, preferably for the use of the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide or the inventive vaccine for the treatment or prophylaxis of a Norovirus infection or diseases or disorders related thereto. The kits may also be applied for the

ID use of the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide or the inventive vaccine for the treatment or prophylaxis of Norovirus infection or diseases or disorders related thereto, wherein the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition

I5 comprising at least one inventive polypeptide or the inventive vaccine may induce or enhance an immune response in a mammal as defined above. Preferably, the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, or the inventive vaccine is provided in a separate part of the kit, wherein the artificial nucleic acid according as described herein, the inventive composition comprising at least one artificial nucleic acid according to the invention, or the inventive vaccine are preferably lyophilised. More preferably, the kit further0 contains as a part a vehicle for solubilising the artificial nucleic acid according as described herein, the inventive composition comprising at least Dne artificial nucleic acid according to the invention, or the inventive vaccine, the vehicle preferably being inger-lactate solution. Any of the above kits may be used in a treatment or prophylaxis as defined above. More preferably, any of the above kits may be used as a vaccine, preferably a vaccine against Norovirus infection or a related disease or disorder. 5 The present invention furthermore provides several applications and uses of the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid accordiog to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide or the inventive vaccine or of kits comprising same. In particular, the inventive (pharmaceutical) composition(s) or the inventive vaccine may be used for human and also for veterinary medical purposes, preferably for human medical purposes, as a pharmaceutical composition in generalD or as a vaccine.

In a further aspect, the invention provides the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts for5 use in a method of prophylactic (pre-exposure prophylaxis or post-exposure prophylaxis) and/or therapeutic treatment of Norovirus infections. Consequently, in a further aspect, the present invention is directed to the first medical use of the artificial nuclEic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts as defined herein as a medicament. Particularly, the invention provides the use of an artificial nucleic acid comprising at least one coding region encoding at least one polypeptide comprising at least 5 one Norovirus protein as defined herein, or a fragment or variant thereof as described herein for the preparation of a medicament.

According to another aspect, the present invention is directed to the second medical use of the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive

ID polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts far the treatment of an infection with Norovirus or a disease or disorder related to an infection with Norovirus as defined herein. Particularly, the artificial nucleic acid comprising at least one coding region encoding at least one polypeptide comprising at least one Norovirus protein as defined herein, or a fragment or variant thereof as described herein to be used in a method as said above is an artificial nucleic acid formulated together with a pharmaceutically acceptable

I5 vehicle and an optionally additional adjuvant and an optionally additional further component as defined herein.

The invention provides the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts for medical use, in particular0 for the treatment of an infection with Norovirus or a disease or disorder related to an infection with Norovirus, wherein preferably an infection with Norovirus may involve any Norovirus strain. More preferably, the Norovirus infection is caused by a Norovirus strain, which is selected from the group consisting of GII.4 CIN-I Norovirus or a GII.4 Sydney Norovirus, Gl.l and GII.4 Sydney 2DI2 Norovirus. Further preferably, the Norovirus infection is caused by a Norovirus strain GII.4 Sydney or GII.4 Sydney 2DI2.

5

As used herein, "a disorder related to a Norovirus infection" or "a disease related to a Norovirus infection" may preferably comprise a complication of Norovirus infection, such as abdominal paio, diarrhea, DIG (disseminated intravascular coagulation), fever, fever/chills, gastrointestinal symptoms, headache, nausea, neck stiffness, obtundation, photophobia, and/or vomiting. In a preferred embodiment, the inventive composition or vaccine is thus used for treatment or prophylaxis, preferably prophylaxis,D of complications associated with a Norovirus infection.

The inventive composition or the inventive vaccine, in particular the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein or the inventive composition comprising at least one inventive polypeptide, can be administered, for example, systemically or locally. Routes for systemic administration in general include, for example, transdermal, oral, parenteral routes, including subcutaneous, intravenous, intramuscular,5 intraarterial, intradermal and intraperitoneal injections and/ or intranasal administration routes. Routes for local administration in general include, for example, topical administration routes but also intradermal, transdermal, subcutaneous, or intramuscular injections or intralesional, intracranial, intrapulmonal, intracardial, and sublingual injections. More preferably, vaccines may be administered by an intradermal, subcutaneous, or intramuscular route. Inventive vaccines are therefore preferably formulated in liquid (or sometimes in solid) form. Preferably, the inventive vaccine may be administered by conventional needle injection or needle-free jet injection. In a preferred embodiment the inventive vaccine or composition may be administered by jet injection as defined herein, preferably intramuscularly or intradermal^, more preferably intradermally.

In a preferred embodiment, a single dose of the inventive artificial nucleic acid, composition or vaccine comprises a specific amount of the artificial nucleic acid according to the invention. Preferably, the inventive artificial nucleic acid is provided in an amount of at least ID pg per dose, 40 pg per dose, preferably in an amount of from 4D to 70D pg per dose, more preferably in an amount of from 80 to 4DD pg per dose. More specifically, in the case of intradermal injection, which is preferably carried out by using a conventional needle, the amount of the inventive artificial nucleic acid comprised in a single dose is typically at least 2D0 pg, preferably from 2DD pg to 1,000 pg, more preferably from 300 pg to 850 pg, even more preferably from 300 pg to 7DD pg. In the case of intradermal injection, which is preferably carried out via jet injection (e.g. using a Tropis device), the amount of the inventive artificial nucleic acid comprised in a single dose is typically at least 80 pg, preferably from 80 pg to 700 pg, more preferably from 80 pg to 400 pg. Moreover, in the case of intramuscular injection, which is preferably carried out by using a conventional needle or via jet injection, the amount of the inventive artificial nucleic acid comprised in a single dose is typically at least 80 pg, preferably from 80 pg to I0D0 pg, more preferably from 80 pg to 850 pg, even more preferably from 80 pg to 700 pg. Depending on the used formulation, the used route of application, and depending on the subject (human, animal), the dose of the inventive artificial nucleic acid may range from about I pg to about ID00 pg, preferably from about 10 pg to about 500 pg.

The immunization protocol for the treatment or prophylaxis of a Norovirus infection, i.e the immunization of a subject against Norovirus, typically comprises a series of single doses or dosages of the inventive composition or the inventive vaccine. A single dosage, as used herin, refers to the initial/first dose, a second dose or any futher doses, respectively, which are preferably administered in order to "boost" the immune reaction.

According to a preferred embodiment, the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts is provided for use in treatment or prophylaxis, preferably treatment or prophylaxis of a Norovirus infection or a related disorder or disease, wherein the treatment or prophylaxis comprises the administration of a further active pharmaceutical ingredient. More preferably, in the case of the inventive vaccine or composition, which is based on the inventive artificial nucleic acid, a polypeptide may be co-administered as a further active pharmaceutical ingredient. For example, at least one Norovirus protein as described herein, or a fragment or variant thereof, may be co-administered in order to induce or enhance an immune response. Likewise, in the case of the inventive vaccine or composition, which is based on the inventive polypeptide as described herein, an artificial nucleic acid as described herein may be co-administered as a further active pharmaceutical ingredient. For example, an artificial nucleic acid as described herein encoding at least one polypeptide as described herein may be co-administered in order to induce or enhance an immune response.

A further component of the inventive vaccine or composition may be an immunotherapeutic agent that can be selected from immunoglobulins, preferably IgGs, monoclonal or polyclonal antibodies, polyclonal serum or sera, etc, most preferably immunoglobulins directed against a Norovirus, Preferably, such a further immunotherapeutic agent may bB provided as a peptide/protein or may be encoded by a nucleic acid, preferably by a DNA or an RNA, more preferably an mRNA. Such an immunotherapeutic agent allows providing passive vaccination additional to active vaccination triggered by the inventive artificial nucleic acid or by the inventive polypeptide.

In a further aspect the invention provides a method of treating or preventing a disorder, wherein the disorder is preferably an infection with Norovirus or a disorder related to an infection with Norovirus, wherein the method comprises administering to a subject in need thereof the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts.

In particular, such a method may preferably comprise the steps of:

a) providing the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts; b) applying or administering the artificial nucleic acid according to the invention, the inventive composition comprising at least one artificial nucleic acid according to the invention, the inventive polypeptides as described herein, the inventive composition comprising at least one inventive polypeptide, the inventive vaccine or the inventive kit or kit of parts to a tissue or an organism;

c) optionally administering immune globuline against Norovirus.

According to a further aspect, the present invention also provides a method for expression of at least one polypeptide comprising at least one Norovirus, or a fragment or variant thereof, wherein the method preferably comprises the following steps:

a) providing the inventive artificial nucleic acid comprising at least one coding region encoding at least one polypeptide comprising at least one Norovirus, or a fragment or variant thereof, preferably as defined herein, or a composition comprising said artificial nucleic acid; and

b) applying or administering the inventive artificial nucleic acid or the inventive composition comprising said artificial nucleic acid to an expression system, e.g. to a cell-free expression system, a cell (e.g. an expression host cell or a somatic cell), a tissue or an organism. The method may be applied for laboratory, for research, for diagnostic, for commercial production of peptides or prateins and/ or for therapeutic purposes. In this context, typically after preparing the inventive artificial nucleic acid as defined herein or of the inventive composition or vaccine as defined herein, it is typically applied or administered to a cell-free expression system, a cell (e.g. an expression host cell or a somatic cell), a tissue or an organism, e.g. in naked or complexed form or as a (pharmaceutical) 5 composition or vaccine as described herein, preferably via transfection or by using any of the administration modes as described herein. The method may be carried out in vitro, in vivo or ex vivo. The method may furthermore be carried out in the context of the treatment of a specific disease, particularly in the treatment of infectious diseases, preferably Norovirus infection or a related disorder as defined herein.

ID In this context, in vitro is defined herein as transfection or transduction of the inventive artificial nucleic acid as defined herein or of the inventive composition or vaccine as defined herein into cells in culture outside of an organism; in vivo is defined herein as transfection or transduction of the inventive artificial nucleic acid or of the inventive composition or vaccine into cells by application of the inventive m NA or of the inventive composition to the whole organism or individual and ex vivo is defined herein as transfection or transduction of the inventive artificial nucleic acid or of the inventive composition or vaccine into cells outside

I5 of an organism or individual and subsequent application of the transfeeted cells to the organism or individual.

Likewise, according to another aspect, the present invention also provides the use of the inventive artificial nucleic acid as defined herein or of the inventive composition or vaccine as defined herein, preferably for diagnostic or therapeutic purposes, for expression of an encoded antigenic peptide or protein, e.g. by applying or administering the inventive artificial nucleic acidD as defined herein or of the inventive composition or vaccine as defined herein, e.g. to a cell-free expression system, a cell (e.g. an expression host cell or a somatic cell), a tissue or an organism. The use may be applied for a (diagnostic) laboratory, for research, for diagnostics, for commercial production of peptides or proteins and/or for therapeutic purposes. In this context, typically after preparing the inventive artificial nucleic acid as defined herein or of the inventive composition or vaccine as defined herein, it is typically applied or administered to a cell-free expression system, a cell (e.g. an expression host cell or a5 somatic cell), a tissue or an organism, preferably in naked form or complexed form, or as a (pharmaceutical) composition or vaccine as described herein, preferably via transfection or by using any of the administration modes as described herein. The use may be carried out in vitro, in vivo or ex vivo. The use may furthermore be carried out in the context of the treatment of a specific disease, particularly in the treatment of Norovirus infection or a related disorder. D In a particularly preferred embodiment, the invention provides the artificial nucleic acid, the inventive composition or the inventive vaccine for use as defined herein, preferably for use as a medicament, for use in treatment or prophylaxis, preferably treatment or prophylaxis of a Norovirus infection or a related disorder, or for use as a vaccine. The vaccine or composition according to the invention can be used according to the invention for human and also for veterinary medical purposes (mammals, vertebrates), as a pharmaceutical composition or as a vaccine.

5 Adjuvants:

According to another embodiment, the (pharmaceutical) composition or vaccine according to the invention may comprise an adjuvant, which is preferably added in order to enhance the immunostimulatory properties of the composition. In this context, an adjuvant may be understood as any compound, which is suitable to support administration and delivery of the composition

5 according to the invention. Furthermore, such an adjuvant may, without being bound thereto, initiate or increase an immune response of the innate immune system, i.e. a non-specific immune response. In other words, when administered, the composition according to the invention typically initiates an adaptive immune response due to an antigen as defined herein or a fragment or variant thereof, which is encoded by the at least one coding sequence of the inventive mRNA contained in the composition of the present invention. Additionally, the composition according to the invention may generate an (supportive) innate immune response

I0 due to addition of an adjuvant as defined herein to the composition according to the invention.

Particularly preferred, an adjuvant may be selected from adjuvants, which support induction of a Thl-immune response or maturation of naive T-cells, such as GM-CSF, IL-I2, IFND, any immunostimulatory nucleic acid as defined above, preferably an immunostimulatory RNA, CpG DNA, etc.

I5

In a further preferred embodiment it is also possible that the inventive composition contains besides the antigen-providing mRNA further components which are selected from the group comprising: further antigens (e.g. in the form of a peptide or protein) or further antigen-encoding nucleic acids; a further immunotherapeutic agent; one or more auxiliary substances; or any further compound, which is known to be immunostimulating due to its binding affinity (as ligands) to human Toll-like receptors; and/orD an adjuvant nucleic acid, preferably an immunostimulatory RNA (isRNA).

The composition of the present invention can additionally contain one or more auxiliary substances in order to increase its immunogenicity or immunostimulatory capacity, if desired. A synergistic action of the mRNA as defined herein and of an auxiliary substance, which may be optionally contained in the inventive composition, is preferably achieved thereby. Depending on the5 various types of auxiliary substances, various mechanisms can come into consideration in this respect. For example, compounds that permit the maturation of dendritic cells (DCs), for example lipnpolysaccharides. TNF-alpha or CD4D ligand, form a first class of suitable auxiliary substances. In general, it is possible to use as auxiliary substance any agent that influences the immune system in the manner of a "danger signal" (LPS, GP36, etc.) or cytokines, such as GM-CFS, which allow an immune response to be enhanced and/or influenced in a targeted manner. Particularly preferred auxiliary substances are cytokines, such asD monokines, lymphokines, interleukins or chemokines, that further promote the innate immune response, such as IL-I, IL-2. IL-3.

IL-4. IL-5. IL-G, IL-7, IL-B. IL-9, IL-ID, IL-I2, IL-I3. IL-I4. IL-I5, IL-IG, IL-I7, IL-I8. IL-I9. IL-20. IL-2I, IL-22, IL-23, IL-24, IL-25. IL-26. IL- 27, IL-28, IL-2B, IL-3D, IL-3I. IL-32, IL-33, IFN-alpha, IFN-beta, IFN-gamma, GM-CSF, G-CSF, M-CSF, LT-beta or TNF-alpha, growth factors, such as hGH. 5 Suitable adjuvants may also be selected from cationic or polycationic compounds wherein the adjuvant is preferably prepared upon complexing the mRNA of the composition according to the invention with the cationic or polycationic compound. Associating or complexing the mRNA of the composition with cationic or polycationic compounds as defined herein preferably provides adjuvant properties and confers a stabilizing effect to the mRNA of the composition. In particular, such preferred cationic or polycationic compounds are selected from cationic or polycationic peptides or proteins, including protamine, nucleoline, spermin or spermidine, or other cationic peptides or proteins, such as poly-L-lysine (PLL), poly-arginine, basic polypeptides, cell

5 penetrating peptides (CPPs), including HIV-binding peptides, Tat, HIV-I Tat (HIV), Tat-derived peptides, Penetratin, VP22 derived or analog peptides, HSV VP22 (Herpes simplex), MAP, KALA or protein transduction domains (PTDs, PpTG2D, prolin-rich peptides, arginine-rich peptides, lysine-rich peptides, MPG-peptide(s), Pep-I, L-oligomers, Calcitonin peptide(s), Antennapedia-derived peptides (particularly from Drosophila antennapedia), pAntp, plsl, FGF, Lactoferrin, Transportan, Buforin-2, Bac7l5-24, SynB, SynB(l), pVEC, hCT-derived peptides, SAP, protamine, spermine, spermidine, or histones. Further preferred cationic or

ID polycationic compounds may include cationic polysaccharides, for example chitosan, polybrene, cationic polymers, e.g. polyethyleneimine (PEI). cationic lipids, e.g, DDTMA: [l-(2,3-sinleyloxy)propyl)]-N,N,N-trimethylammonium chloride, D RIE. di-CI4- amidine. OOTIM, SAINT, DC-Chol. BGTC, CTAP, DOPC. DODAP. DOPE: Dioleyl phosphatidylethanol-amine. DDSPA, DODAB, DDIC. DMEPC, DOBS: Dioctadecylamidoglicylspermin, DIMRI: Dimyristo-oxypropyl dimethyl hydroxyethyl ammonium bromide, DDTAP: dioleoyloxy-3-(trimethylammonio)propane, DC-FJ-I4: D,0-ditetradecanoyl-N-(a-trimethylammonioacetyl)diethanolami ne

I5 chloride, CLIPI: rac-[(2,3-dioctadecyloxypropyl)(2-hydroxyethyl)]-dimethylamm onium chloride, CLIPG: rac-[2(2.3- dihexadecyloxypropyl-oxymethyloxy)ethyl]-trimethylammonium, CLIPS: rac-[2(2,3-dihexadecyloxypropyl-oxysuccinyloxy)ethyl]- trimethylammonium, oligofectamine, or cationic or polycationic polymers, e.g. modified polyaminoacids, such as β-aminoacid- polymers or reversed polyamides, etc., modified polyethylenes, such as PVP (poly(N-ethyl-4-vinylpyridinium bromide)), etc., modified acrylates, such as pDMAEMA (poly(dimethylaminoethyl methylacrylate)), etc., modified Amidoamines such as pAMAM0 (poly(amidoamine)), etc., modified polybetaaminoester (PBAE), such as diamine end modified l,4 butanediol diacrylate-co-5- amino-l-pentanol polymers, etc., dendrimers, such as polypropylamine dendrimers or pAMAM based dendrimers, etc., polyimine(s), such as PEI: poly(ethyleneimine), poly(propyleneimine), etc., polyallylamine, sugar backbone based polymers, such as cyclodextrin based polymers, dextran based polymers, Chitosan, etc., silan backbone based polymers, such as PMOXA-PDMS copolymers, etc., blockpolymers consisting of a combination of one or more cationic blocks (e.g. selected of a cationic polymer5 as mentioned above) and of one or more hydrophilic- or hydrophobic blocks (e.g polyethyleneglycole); etc.

Additionally, preferred cationic or polycationic proteins or peptides, which can be used as an adjuvant by complexing the mRNA of the composition according to the invention, may be selected from following proteins or peptides having the following total formula (III): (Arg)l:(Lys)m;(His)n;(Orn)o;(Xaa)x, wherein l + m + n +a + x = 8-I5, and I. m, n or o independently of each other may0 be any number selected from 0, 1, 2, 3, 4, 5, G, 7, 8, 9, ID, II. I2. 13, 14 or I5, provided that the overall content of Arg, Lys, His and Dm represents at least 50% of all amino acids of the oligopeptide: and Xaa may be any amino acid selected from native (= naturally occurring) or non-native amino acids except of Arg, Lys, His or Drn; and x may be any number selected from 0, 1, 2. 3 or 4, provided, that the overall content of Xaa does not exceed 50% of all amino acids of the oligopeptide. Particularly preferred oligoarginines in this context are e.g. Arg7, ArgS. ArgB. Arg7. H3R9, R9H3, H3R9H3, YSSR9SSY, (RKH)4, Y(RKH)2R, etc.

5 The ratio of the mRNA to the cationic or polycationic compound in the adjuvant component may be calculated on the basis of the nitrogen/phosphate ratio (N/P-ratio) of the entire mRNA complex, i.e. the ratio of positively charged (nitrogen) atoms of the cationic or polycationic compound to the negatively charged phosphate atoms of the nucleic acids. For example, I pg of RNA typically contains about 3 nmol phosphate residues, provided the RNA exhibits a statistical distribution of bases. Additionally, I

5 pg of peptide typically contains about x nmol nitrogen residues, dependent on the molecular weight and the number of basic amino acids. When exemplarily calculated for (Arg)9 (molecular weight I424 g/ mol, 9 nitrogen atoms), I pg (Arg)E contains about 7DD pmol (Arg)9 and thus 70D x 9=6300 pmol basic amino acids = 6.3 nmol nitrogen atoms. For a mass ratio of about l:l RNA/(Arg)9 an N/P ratio of about 2 can be calculated. When exemplarily calculated for protamine (molecular weight about 4250 g/mol, 2I nitrogen atoms, when protamine from salmon is used) with a mass ratio of about 2:l with 2 pg RNA, 6 nmol phosphate

I0 are to be calulated for the RNA; I pg protamine contains about 235 pmol protamine molecues and thus 235 x 2I = 4935 pmol basic nitrogen atoms = 4.9 nmol nitrogen atoms. For a mass ratio of about 2:l RNA/protamine an N/P ratio of about 0.8I can be calculated. For a mass ratio of about 8:l RNA/protamine an N/P ratio of about 0.2 can be calculated. In the context of the present invention, an N/P-ratio is preferably in the range of about 0.I-I0, preferably in a range of about 0.3-4 and most preferably io a range of about 0.5-2 or 0.7-2 regarding the ratio of RNA : peptide in the complex, and most preferably in the range of about 0.7-

I5 I.5.

In a preferred embodiment, the composition of the present invention is obtained in two separate steps in order to obtain both, an efficient immunostimulatory effect and efficient translation of the mRNA according to the invention. Therein, a so called "adjuvant component" is prepared by complexing - in a first step - an mRNA as defined herein of the adjuvant component with a0 cationic or polycationic compound in a specific ratio to form a stable complex. In this context, it is important, that no free cationic or polycationic compound or only a negligibly small amount remains in the adjuvant component after complexing the mRNA. Accordingly, the ratio of the mRNA and the cationic or polycationic compound in the adjuvant component is typically selected in a range that the mRNA is entirely complexed and no free cationic or polycatiooic compound or only a negligible small amount remains in the composition. Preferably the ratio of the adjuvant component, i.e. the ratio of the mRNA to the cationic or5 polycationic compound is selected from a range of about 6:l (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w/w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w).

According to a preferred embodiment, the mRNA of the invention comprising at least one mRNA sequence comprising at least0 one coding region as defined herein is added in a second step to the complexed mRNA of the adjuvant component in order to form the (immunostimulatory) composition of the invention. Therein, the mRNA of the composition according to the invention is added as free mRNA, which is not complexed by other compounds. Prior to addition, the free mRNA is not complexed and will preferably not undergo any detectable or significant complexation reaction upon the addition of the adjuvant component. This is due to the strong binding of the cationic or polycationic compound to the above described mRNA according to the invention comprised in5 the adjuvant component. In other words, when the mRNA comprising at least one coding region as defined herein is added to the "adjuvant component", preferably no free or substantially no free cationic or polycationic compound is present, which could form a complex with the free mRNA. Accordingly, an efficient translation of the mRNA of the composition is possible in vivo. Therein, the free mRNA, may occur as a mono-, di-, or multicistronic mRNA, i.e. an mRNA which carries the coding sequences of one or more proteins. Such coding sequences in di-, or even multicistronic mRNA may be separated by at least one IRES sequence, E.g. as dBfined herein.

5

In a particularly preferred embodiment, the free mRNA as defined herein, which is comprised in the composition of the present invention, may be identical or different to the RNA as defined herein, which is comprised in the adjuvant componEnt of the composition, depending on the specific rEquirEments of therapy. Even more preferably, the free RNA, which is comprised in the composition according to the invention, is identical to the RNA of the adjuvant component of the inventive composition.

I0

In a particularly preferred embodiment, the composition according to the invention comprises the mRNA of the invention, which encodes at least one antigenic peptide or protein as defined herein and wherEin said mRNA is present in the composition partially as free mRNA and partially as complexed mRNA. PrefErably, the mRNA as defined herein is complexed as described above and the samB mRNA is then added as free mRNA, wherein preferably the compound, which is used for complexing the mRNA is not I5 present in free form in the composition at the moment of addition of the free mRNA component.

The ratio of the first component (i.e. the adjuvant component comprising or consisting of the mRNA as defined herein complexed with a cationic or polycationic compound) and the second component (i.e. the free mRNA as defined herein) may be selected in the inventive composition according to the specific requirements of a particular therapy. Typically, the ratio of the mRNA in theD adjuvant component and the at least one free mRNA (mRNA in the adjuvant component : free mRNA) of the composition according to the invention is selected such that a significant stimulation of the innate immune system is elicited due to the adjuvant component. In parallel, the ratio is selected such that a significant amount of the free mRNA can be provided in vivo leading to an efficient translation and concentration of the Expressed protein in vivo. E.g. the at least one antigenic peptide or protein as defined herein. Preferably the ratio of the mRNA in the adjuvant component : free mRNA in the inventive composition is selected5 from a range of about 5:l (w/w) to about l:ID (w/w), morB preferably from a range of about 4:l (w/w) to about l:8 (w/w), even more preferably from a range of about 3:l (w/w) to about l:5 (w/w) or l:3 (w/w), and most preferably the ratio of mRNA in the adjuvant component : free mRNA in the inventive composition is selected from a ratio of about l:l (w/w).

Additionally or alternatively, the ratio of the first component (i.e. the adjuvant component comprising or consisting of the mRNAD complexed with a cationic or polycationic compound) and the second component (i.e. the free mRNA) may be calculated on the basis of the nitrogen/phosphate ratio (N/P-ratio) of the entire mRNA complex. In the context of the present invention, an N/P- ratio is preferably in the rangE of about D.I-ID, preferably in a range of about 0.3-4 and most preferably in a range of about 0.5- 2 or 0.7-2 regarding the ratio of mRNA : peptide in the complEx, and most preferably in the range of about 0.7-I.5. 5 Additionally or alternatively, the ratio of the first component (i.e. the adjuvant component comprising or consisting of the mRNA complexed with a cationic or polycationic compound) and the second component (i.e. the free mRNA) may also be selected in the campositiDn according to the invention on the basis of the molar ratio of both mRNAs to each other, i.e. the mRNA of the adjuvant component, being complexed with a cationic or polycationic compound and the free mRNA of the second component. Typically, the molar ratio of the mRNA of the adjuvant component to the free mRNA of the second component may be selected such, that the molar ratio suffices the above (w/w) and/or N/P-definitions. More preferably, the molar ratio of the mRNA of the adjuvant component to the free mRNA of the second component may be selected e.g. from a molar ratio of about 0.001:1, D.DI:I, D.l:l, 0,2:1. 0.3:1, 0.4:1, 0.5:1, 0.6:1. 0.7:1, 0.8:1. 0.0:1, 1:1, 1:0.9. 1:0.8, 1:0.7, 1:0.0, 1:0.5, 1:0.4. 1:0.3, 1:0.2, 1:0.1, 1:0.01, 1:0.001, etc. or from any range formed by any two of the above values, e.g. a range selected from about 0.001:1 to 1:0.001, including a range of about 0.01:1 to 1:0.001, 0.1:1 to 1:0.001, 0.2:1 to 1:0.001, 0.3:1 to 1:0.001, 0.4:1 to 1:0.001. 0.5:1 to 1:0.001, 0.6:1 to 1:0.001, 0.7:1 to 1:0.001, 0.8:1 to 1:0.001, 0.9:1 to 1:0.001, 1:1 to 1:0.001, 1:0.9 to 1:0.001, 1:0.8 to 1:0.001, 1:0.7 to 1:0.001, 1:0.6 to 1:0.001, 1:0.5 to 1:0.001, 1:0.4 to 1:0.001, 1:0.3 to 1:0.001, 1:0.2 to 1:0.001.1:0.1 to 1:0.001, 1:0.01 to 1:0.001, or a range of about 0.01:1 to 1:0.01, 0.1:1 to 1:0.01, 0.2:1 to 1:0.01, 0.3:1 to 1:0.01, 0.4:1 to 1:0.01, 0.5:1 to 1:0.01, 0.6:1 to 1:0.01, 0.7:1 to 1:0.01, 0.8:1 to 1:0.01, 0.9:1 to 1:0.01, 1:1 to 1:0.01, 1:0.9 to 1:0.01, 1:0.8 to 1:0.01. 1:0.7 to 1:0.01, 1:0.6 to 1:0.01, 1:0.5 to 1:0.01, 1:0.4 to 1:0.01, 1:0.3 to 1:0.01, 1:0.2 to 1:0.01, 1:0.1 to 1:0.01. 1:0.01 to 1:0.01, or including a range of about 0.001:1 to 1:0.01, 0.001:1 to 1:0.1. 0.001:1 to 1:0.2, 0.001:1 to 1:0.3, 0.001:1 to 1:0.4. 0.001:1 to 1:0.5, 0.001:1 to 1:0.6. 0.001:1 to 1:0.7, 0.001:1 to 1:0.8, 0.001:1 to 1:0.9. 0.001:1 to 1:1, 0.001 to 0.9:1, 0.001 to 0.8:1, 0.001 to 0.7:1, 0.001 to 0.6:1, 0.001 to 0.5:1, 0.001 to 0.4:1, 0.001 to 0.3:1, 0.001 to 0.2:1. 0.001 to 0.1:1. or a range of about 0.01:1 to 1:0.01, 0.01:1 to 1:0.1, 0.01:1 to 1:0.2, 0.01:1 to 1:0.3, 0.01:1 to 1:0.4, 0.01:1 to 1:0.5, 0.01:1 to 1:0.6, 0.01:1 to 1:0.7. 0.01:1 to 1:0.8, 0.01:1 to 1:0.9, 0.01:1 to 1:1, 0.001 to 0.9:1, 0.001 to 0.8:1, 0.0DI to 0.7:1, 0.001 to 0.6:1, 0.001 to 0.5:1, 0.001 to 0.4:1. 0.001 to 0.3:1. 0.001 to 0.2:1, 0.001 to 0.1:1, etc.

Even more preferably, the molar ratio of the mRNA of the adjuvant component to the free mRNA of the second component may be selected e.g. from a range of about 0.01:1 to 1:0.01. Most preferably, the molar ratio of the mRNA of the adjuvant component to the free mRNA of the second component may be selected e.g. from a molar ratio of about 1:1. Any of the above definitions with regard to (w/w) and/or N/P ratio may also apply.

Suitable adjuvants may furthermore be selected from nucleic acids having the formula (Va): GIXmGn, wherein: G is guanosine, uracil or an analogue of guanosine or uracil: X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above- mentioned nucleotides: I is an integer from I to 40, wherein when I = I G is guanosine or an analogue thereof, when I > I at least 50% of the nucleotides are guanosine or an analogue thereof: m is an integer and is at least 3; wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur: n is an integer from I to 40, wherein when n = I G is guanosine or an analogue thereof, when n > I at least 50% of the nocleotides are guanosine or an analogue thereof, or formula (Vb): (NuGIXmGnNv)a. wherein: G is guanosine (guanine), uridine (uracil) or an analogue of guanosine (guanine) or uridine (uracil), preferably guanosine (guanine) or an analogue thereof; X is guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosioe), or an analogue of these nucleotides (nucleosides), preferably uridine (uracil) or an analogue thereof; N is a nucleic acid sequence having a length of about 4 to 50, preferably of about 4 to 40, more preferably of about 4 to 30 or 4 to 20 nucleic acids, each N independently being selected from guanosine (guanine), uridine (uracil), adenosine (adenine), thymidine (thymine), cytidine (cytosine) or an analogue of these nucleotides (nucleosides); a is an integer from I to 20, preferably from I to 15, most preferably from I to 10; I is an integer from I to 40, wherein when I = I, G is guanosine (guanine) or an analogue thereof, when I > I, at least 50% of these nucleotides (nucleosides) are guanosine (guanine) or an analogue thereof; m is an integer and is at least 3; wherein when m = 3, X is uridine (uracil) or an analogue thereof, and when m > 3, at least 3 successive uridines (uracils) or analogues of uridine (uracil) occur; n is an integer from I to 40, wherein when n = I, G is guanosine (guanine) or an analogue thereof, when n > I, at least 50% of these nucleotides (nucleosides) are guanosine 5 (guanine) or an analogue thereof; u,v may be independently from each other an integer from 0 to 50, preferably wherein when u = 0, v≥ I, or when v = 0, u > I; wherein the nucleic acid molecule of formula (Vb) has a length of at least 50 nucleotides, preferably of at least I00 nucleotides, more preferably of at least ISO nucleotides, even more preferably of at least 200 nucleotides and mast preferably of at least 25D nucleotides.

I0 Other suitable adjuvants may furthermore be selected from nucleic acids having the formula (VI): ClXmCn, wherein: C is cytosine, uracil or an analogue of cytosine or uracil; X is guanosine, uracil, adenosine, thymidine, cytosine or an analogue of the above- mentioned nucleotides; I is an integer from I to 40, wherein when I = I C is cytosine or an analogue thereof, when I > I at least 50% of the nucleotides are cytosine or an analogue thereof; m is an integer and is at least 3; wherein when m = 3 X is uracil or an analogue thereof, when m > 3 at least 3 successive uracils or analogues of uracil occur; n is an integer from I to 40, wherein

I5 when n = I C is cytosine or an analogue thereof, when n > I at least 50% of the nucleotides are cytosine or an analogue thereof.

In this context the disclosure of W0 2008/0I4979 and W0 2009/D9522B is also incorporated herein by reference.

In a further aspect, the present invention provides a vaccine, which is based on the mRNA sequence according to the invention0 comprising at least one coding region as defined herein. The vaccine according to the invention is preferably a (pharmaceutical) composition as defined herein.

Accordingly, the vaccine according to the invention is based on the same components as the (pharmaceutical) composition described herein. Insofar, it may be referred to the description of the (pharmaceutical) composition as provided herein.5 Preferably, the vaccine according to the invention comprises at least one mRNA comprising at least one mRNA sequence as defined herein and a pharmaceutically acceptable carrier. In embodiments, where the vaccine comprises more than one mRNA sequence (such as a plurality of RNA sequences according to the invention, wherein each preferably encodes a distinct antigenic peptide or protein), the vaccine may be provided in physically separate form and may be administered by separate administration steps. The vaccine according to the invention may correspond to the (pharmaceutical) composition as described herein,0 especially where the mRNA sequences are provided by one single composition. However, the inventive vaccine may also be provided physically separated. For instance, in embodiments, wherein the vaccine comprises more than one mRNA sequences/species, these RNA species may be provided such that, for example, two, three, four, five or six separate compositions, which may contain at least one mRNA species/sequence each (e.g. three distinct mRNA species/sequences), each encoding distinct antigenic peptides or proteins, are provided, which may or may not be combined. Also, the inventive vaccine5 may be a combination of at least two distinct compositions, each composition comprising at least one mRNA encoding at least one of the antigenic peptides or proteins defined herein. Alternatively, the vaccine may be provided as a combination of at least one mRNA, preferably at least two, three, four, five, six or more mRNAs, each encoding one of the antigenic peptides or proteins defined herein. The vaccine may be combined to provide one single composition prior to its use or it may be used such that more than one administration is required to administer the distinct mRNA sequences/species encoding any of the antigenic peptides or proteins as defined herein. If the vaccine contains at least one mRNA sequence, typically at least two mRNA sequences,

5 encoding the antigen combinations defined herein, it may e.g. be administered by one single administration (combining all mRNA species/sequences), by at least two separate administrations. Accordingly; any combination of mono-, bi- or multicistronic mRNAs encoding the at least one antigenic peptide or protein or any combination of antigens as defined herein (and optionally further antigens), provided as separate entities (containing one mRNA species) or as combined entity (containing more than one mRNA species), is understood as a vaccine according to the present invention. According to a particularly preferred embodiment

IQ of the inventive vaccine, the at least one antigen, preferably a combination as defined herein of at least two, three, four, five, six or more antigens encoded by the inventive composition as a whole, is provided as an individual (monocistronic) mRNA, which is administered separately.

As with the (pharmaceutical) composition according to the present invention, the entities of the vaccine may be provided in liquid I5 and or in dry (e.g. lyophilized) form. They may contain further components, in particular further components allowing for its pharmaceutical use. The vaccine or the (pharmaceutical) composition may, e.g., additionally contain a pharmaceutically acceptable carrier and/or further auxiliary substances and additives and/or adjuvants.

The vaccine or (pharmaceutical) composition typically comprises a safe and effective amount of the mRNA according to theD invention as defined herein, encoding an antigenic peptide or protein as defined herein or a fragment or variant thereof or a combination of antigens, preferably as defined herein. As used herein, "safe and effective amount" means an amount of the mRNA that is sufficient to significantly induce a positive modification of cancer or a disease or disorder related to cancer. At the same time, however, a "safe and effective amount" is small enough to avoid serious side-effects, that is to say to permit a sensible relationship between advantage and risk. The determination of these limits typically lies within the scope of sensible medical5 judgment. In relation to the vaccine or (pharmaceutical) composition of the present invention, the expression "safe and effective amount" preferably means an amount of the mRNA (and thus of the encoded antigen) that is suitable for stimulating the adaptive immune system in such a manner that no excessive or damaging immune reactions are achieved but, preferably, also no such immune reactions below a measurable level. Such a "safe and effective amount" of the mRNA of the (pharmaceutical) composition or vaccine as defined herein may furthermore be selected in dependence of the type of mRNA, e.g. monocistronic, bi- or evenD multicistronic mRNA, since a bi- or even multicistronic mRNA may lead to a significantly higher expression of the encoded antigen(s) than the use of an equal amount of a monocistronic mRNA. A "safe and effective amount" of the mRNA of the (pharmaceutical) composition or vaccine as defined above will furthermore vary in connection with the particular condition to be treated and also with the age and physical condition of the patient to be treated, the severity of the condition, the duration of the treatment, the nature of the accompanying therapy, of the particular pharmaceutically acceptable carrier used, and similar5 factors, within the knowledge and experience of the accompanying doctor. The vaccine or composition according to the invention can be used according to the. invention for human and also for veterinary medical purposes, as a pharmaceutical composition or as a vaccine.

In a preferred embodiment, the mRNA of the (pharmaceutical) composition, vaccine or kit of parts according to the invention is provided in lyophilized form. Preferably, the lyophilized mRNA is reconstituted in a suitable buffer, advantageously based on an aqueous carrier, prior to administration, e.g. Ringer-Lactate solution, which is preferred, Ringer solution, a phosphate buffer solution. In a preferred embodiment, the (pharmaceutical) composition, the vaccine or the kit of parts according to the invention contains at least one, two, three, four, five, six or more mRNAs, preferably mRNAs which are provided separately in lyophilized form (optionally together with at least one further additive) and which are preferably reconstituted separately in a suitable buffer (such as Ringer-Lactate solution) prior to their use so as to allow individual administration of each of the (monocistronic) mRNAs.

The vaccine or (pharmaceutical) composition according to the invention may typically contain a pharmaceutically acceptable carrier. The expression "pharmaceutically acceptable carrier" as used herein preferably includes the liquid or non-liquid basis of the inventive vaccine. If the inventive vaccine is provided in liquid form, the carrier will be water, typically pyrogen-free water; isotonic saline or buffered (aqueous) solutions, e.g phosphate, citrate etc. buffered solutions. Particularly for injection of the inventive vaccine, water or preferably a buffer, more preferably an aqueous buffer, may be used, containing a sodium salt, preferably at least 5D mM of a sodium salt, a calcium salt, preferably at least 0,01 mM of a calcium salt, and optionally a potassium salt, preferably at least 3 mM of a potassium salt. According to a preferred embodiment, the sodium, calcium and, optionally, potassium salts may occur in the form of their halogenides, e.g. chlorides, iodides, or bromides, in the form of their hydroxides, carbonates, hydrogen carbonates, or sulfates, etc. Without being limited thereto, examples of sodium salts include e.g. NaCI, Nal, NaBr, Na2CD3, NaHCD3, Na2SD4. examples of the optional potassium salts include e.g. KCI. Kl, KBr, 2C03, KHC03, K2S04. and examples of calcium salts include e.g. CaCI2, Cal2, CaBr2, CaC03, CaS04, Ca(0H)2. Furthermore, organic anions of the aforementioned cations may be contained in the buffer. According to a more preferred embodiment, the buffer suitable for injection purposes as defined above, may contain salts selected from sodium chloride (NaCI), calcium chloride (GaCI2) and optionally potassium chloride (KCI), wherein further anions may be present additional to the chlorides. CaCI2 can also be replaced by another salt like KCI. Typically, the salts in the injection buffer are present in a concentration of at least 50 mM sodium chloride (NaCI), at least 3 mM potassium chloride (KCI) and at least 0,01 mM calcium chloride (CaCI2). The injectioo buffer may be hypertonic, isotonic or hypotonic with reference to the specific reference medium, i.e. the buffer may have a higher, identical or lower salt content with reference to the specific reference medium, wherein preferably such concentrations of the afore mentioned salts may be used, which do not lead to damage of cells due to osmosis or other concentration effects. Reference media are e.g. in "in vivo" methods occurring liquids such as blood, lymph, cytosolic liqoids, or other body liquids, or e.g. liquids, which may be used as reference media in "in vitro" methods, such as common buffers or liquids. Such common buffers or liquids are known to a skilled person. Ringer-Lactate solution is particularly preferred as a liquid basis. However, one or more compatible solid or liquid fillers or diluents or encapsulating compounds may be used as well, which are suitable for administration to a person. The term "compatible" as used herein means that the constituents of the inventive vaccine are capable of being mixed with the mRNA according to the invention as defined herein, in such a manner that no interaction occurs, which would substantially reduce the pharmaceutical effectiveness of the inventive vaccine under typical use conditions.

5 Pharmaceutically acceptable carriers, fillers and diluents must, of course, have sufficiently high purity and sufficiently low toxicity to make them suitable for administration to a person to be treated. Some examples of compounds which can be used as pharmaceutically acceptable carriers, fillers or constituents thereof are sugars, such as, for example, lactose, glucose, trehalose and sucrose; starches, such as, for example, corn starch or potato starch; dextrose; cellulose and its derivatives, such as, for example, sodium carboxymethylcellulose, ethylcellulose, cellulose acetate; powdered tragacanth; malt; gelatin; tallow; solid

ID glidants, such as, for example, stearic acid, magnesium stearate; calcium sulfate; vegetable oils, such as, for example, groundnut oil, cottonseed oil, sesame oil, olive oil, corn oil and oil from theobroma; polyols, such as, for example, polypropylene glycol, glycerol, sorbitol, mannitol and polyethylene glycol; alginic acid.

The choice of a pharmaceutically acceptable carrier is determined, in principle, by the manner, in which the pharmaceutical

I5 composition or vaccine according to the invention is administered. The composition or vaccine can be administered, for example, systemically or locally. Routes for systemic administration in general include, for example, transdermal, oral, parenteral routes, including subcutaneous, intravenous, intramuscular, intraarterial, intradermal and intraperitoneal injections and/or intranasal administration routes. Routes for local administration in general include, for example, topical administration routes but also intradermal, transdermal, subcutaneous, or intramuscular injections or intralesional, intracranial, intrapulmonal, intracardial,0 and sublingual injections. More preferably, composition or vaccines according to the present invention may be administered by an intradermal, subcutaneous, or intramuscular route, preferably by injection, which may be needle-free and/or needle injection. Compositions/vaccines are therefore preferably formulated in liquid or solid form. The suitable amount of the vaccine or composition according to the invention to be administered can be determined by routine experiments, e.g. by using animal models. Such models include, without implying any limitation, rabbit, sheep, mouse, rat, dog and non-human primate models. Preferred5 unit dose forms for injection include sterile solutions of water, physiological saline or mixtures thereof. The pH of such solutions should be adjusted to about 7.4. Suitable carriers for injection include hydrogels, devices for controlled or delayed release, polylactic acid and collagen matrices. Suitable pharmaceutically acceptable carriers for topical application include those which are suitable for use in lotions, creams, gels and the like. If the inventive composition or vaccine is to be administered perorally, tablets, capsules and the like are the preferred unit dose form. The pharmaceutically acceptable carriers for the preparation ofD unit dose forms which can be used for oral administration are well known in the prior art. The choice thereof will depend on secondary considerations such as taste, costs and storability, which are not critical for the purposes of the present invention, and can be made without difficulty by a person skilled in the art.

The inventive vaccine or composition can additionally contain one or more auxiliary substances in order to further increase the5 immunogenicity. A synergistic action of the mRNA contained in the inventive composition and of an auxiliary substance, which may be optionally be co-formulated (or separately formulated) with the inventive vaccine or composition as described above, is preferably achieved thereby. Depending on the various types of auxiliary substances, various mechanisms may play a role in this respect. For example, compounds that permit the maturation of dendritic cells (DCs), for example lipopolysaccharides, TNF-alpha or CD40 ligand, form a first class of suitable auxiliary substances. In general, it is possible to use as auxiliary substance any agent that influences the immune system in the manner of a "danger signal" (LPS, GP9G, etc.) or cytokines, such as GM-CFS,

5 which allow an immune response produced by the immune-stimulating adjuvant according to the invention to be enhanced and/ or influenced in a targeted manner. Particularly preferred auxiliary substances are cytokines, such as monokines, lymphokines, interleukins or chemokinss, that - additional to induction of the adaptive immune response by the encoded at least one antigen - promote the innate immune response, such as IL-I, IL-2. IL-3. IL-4, IL-5. IL-6, IL-7, IL-8, IL-FJ. IL-IO, IL-I2. IL-13. IL-I4. IL-I5, IL-IB, IL-I7, IL-I8, IL-13, IL-2D, IL-ZI. IL-Z2, IL-23, IL-24, IL-25. IL-26, IL-27. IL-28. IL-29, IL-30. IL-31. IL-32. IL-33. INF-alpha, IFN-beta, INF-

ID gamma, GM-CSF, G-CSF, -CSF, LT-beta or TNF-alpha, growth factors, such as hGH. Preferably, such immunogenicity increasing agents or compounds are provided separately (not co-formulated with the inventive vaccine or composition) and administered individually.

Further additives which may be included in the inventive vaccine or composition are emulsifiers, such as, for example, Tween; 15 wetting agents, such as, for example, sodium lauryl sulfate; colouring agents; taste-imparting agents, pharmaceutical carriers; tablet-forming agents; stabilizers; antioxidants; preservatives.

The inventive vaccine or composition can also additionally contain any further compound, which is known to be immune- stimulating due to its binding affinity (as ligands) to human Toll-like receptors TL I, TLR2, TLR3, TLR4, TLR5, TLRG, TLR7, TLR8,D TLR9, TLRID, or due to its binding affinity (as ligands) to murine Toll-like receptors TLRI, TLR2, TLR3, TLR4, TLR5, TLRG, TLR7, TLR8, TLR9, TLRID, TLRII, TLRI2 or TLRI3.

Another class of compounds, which may be added to an inventive vaccine or composition in this context, may be CpG nucleic acids, in particular CpG-RNA or CpG-DNA. A CpG-RNA or CpG-DNA can be a single-stranded CpG-DNA (ss CpG-ONA), a double-5 stranded CpG-DNA (dsDNA), a single-stranded CpG-RNA (ss CpG-RNA) or a double-stranded CpG-RNA (ds CpG-RNA). The CpG nucleic acid is preferably in the form of CpG-RNA, more preferably in the form of single-stranded CpG-RNA (ss CpG-RNA). The CpG nucleic acid preferably contains at least one or more (mitogenic) cytosine/guanine dinucleotide seguence(s) (CpG motif(s)). According to a first preferred alternative, at least one CpG motif contained in these sequences, that is to say the C (cytosine) and the G (guanine) of the CpG motif, is unmethylated. All further cytosines or guanines optionally contained in these sequences0 can be either methylated or unmethylated. According to a further preferred alternative, however, the C (cytosine) and the G (guanine) of the CpG motif can also be present in methylated form.

Application and medical Use:

According to one aspect of the present invention, the mRNA sequence, the (pharmaceutical) composition or the vaccine may be5 used according to the invention (for the preparation of a medicament) for the treatment or prophylaxis of Norovirus infections or disorders related thereto. In this context, also included in the present invention are methods of treating or preventing Norovirus infections or disorders related thereto, preferably as defined herein, by administering to a subject in need thereof a pharmaceutically effective amount of the mRNA sequeoce, the (pharmaceutical) composition or the vaccine according to the invention. Such a method typically 5 comprises an optional first step of preparing the mRNA sequence, the composition or the vaccine of the present invention, and a second step, comprising administering (a pharmaceutically effective amount of) said composition or vaccine to a patient/subject in need thereof. A subject in need thereof will typically be a mammal. In the context of the present invention, the mammal is preferably selected from the group comprising, without being limited thereto, e.g. goat, cattle, swine, dog, cat, donkey, monkey, ape, a rodent such as a mouse, hamster, rabbit and, particularly, human. A subject in need thereof may also be a non- ID mammalian vertebrate, e.g. a bird (chicken).

The invention also relates to the use of the mRNA sequence, the composition or the vaccine according to the invention, preferably for eliciting an immune response in a mammal, preferably for the treatment or prophylaxis of Norovirus infections or a related condition as defined herein.

I5

The present invention furthermore comprises the use of the mRNA sequence, the (pharmaceutical) composition or the vaccine according to the invention as defined herein for modulating, preferably for inducing or enhancing, an immune response in a mammal as defined herein, more preferably for preventing and/or treating Norovirus infections, or of diseases or disorders related thereto. In this context, support of the treatment or prophylaxis of Norovirus infections may be any combination of aD conventional Norovirus therapy method such as therapy with antivirals such as neuraminidase inhibitors (e.g. oseltamivir and zanamivir) and M2 protein inhibitors (e.g. adamantane derivatives), and a therapy using the RNA or the pharmaceotical composition as defined herein. Support of the treatment or prophylaxis of Norovirus infections may be also envisaged in any of the other embodiments defined herein. Accordingly, any use of the mRNA sequence, the (pharmaceutical) composition or the vaccine according to the invention in co-therapy with any other approach, preferably ooe or more of the above therapeutic5 approaches, in particular in combination with antivirals is within the scope of the present invention.

For administration, preferably any of the administration routes may be used as defined herein. In particular, an administration route is used, which is suitable for treating or preventing an Norovirus infection as defined herein or diseases or disorders related thereto, by inducing or enhancing an adaptive immune response on the basis of an antigen encoded by the mRNA sequenceD according to the invention. Administration of the composition and/or the vaccine according to the invention may then occur prior, concurrent and/or subsequent to administering another composition and/or vaccine as defined herein, which may - in addition - contain another mRNA sequence or combination of mRNA sequences encoding a different antigen or combination of antigens, wherein each antigen encoded by the mRNA sequence according to the invention is preferably suitable for the treatment or prophylaxis of Norovirus infections and diseases or disorders related thereto. In this context, a treatment as defined herein5 may also comprise the modulation of a disease associated to Norovirus infection and of diseases or disorders related thereto. According to a preferred embodiment of this aspect of the invention, the (pharmaceutical) composition or the vaccine according to the invention is administered by injection. Any suitable injection technique known in the art may be emplnyed. Preferably, the inventive composition is administered by injection, preferably by needle-less injection, for example by jet-injection, In one embodiment, the inventive composition comprises at least one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more mRNAs as defined herein, each of which is preferably injected separately, preferably by needle-less injection. Alternatively, the inventive composition comprises at least one, two, three, four, five, six, seven, eight, nine, ten, eleven, twelve. I3.14. IS, IB, I7, 18, 19, 20, Zl.22, 23, 24, 25, 26.27, 28.29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43.44, 45, 6, 7.48, 49, 50 or more mRNAs, wherein the at least one. two. three, four, five, six, seven, eight, nine, ten, eleven, twelve, I3, 14, 15, IB, I7, I8, 19, 20. Zl.22.23.24.25, 26, 27, 28, 29.30.31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41.42.43, 44, 45, 46, 47, 48, 9. 5D or more mRNAs are administered, preferably by injection as defined herein, as a mixture.

The immunization protocol for the immunization of a subject against an antigen or a combination of at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more antigens as defined herein typically comprises a series of single doses or dosages of the (pharmaceutical) composition or the vaccine according to the invention. A single dosage, as used herein, refers to the initial/first dose, a second dose or any further doses, respectively, which are preferably administered in order to "boost" the immune reaction. In this context, each single dosage preferably comprises the administration of the same antigen or the same combination of antigens as defined herein, wherein the interval between the administration of two single dosages can vary from at least one day, preferably 2, 3. , 5, 6 or 7 days, to at least one week, preferably 2, 3, 4, 5, 6, 7 or 8 weeks. The intervals between single dosages may be constant or vary over the course of the immunization protocol, e.g. the intervals may be shorter in the beginning and longer towards the end of the protocol. Depending on the total number of single dosages and the interval between single dosages, the immunization protocol may extend over a period of time, which preferably lasts at least one week, more preferably several weeks (e.g.2, 3, 4, 5, B, 7, 8, 9, 10, II or 12 weeks), even more preferably several months (e.g. 3, 4, 5, 6, 7, 8, 9. 10, II, 12, 18 or 24 months). Each single dosage preferably encompasses the administration of an antigen, preferably of a combination of at least two, three, four, five, six, seven, eight, nine, ten, eleven, twelve or more antigens as defined herein and may therefore involve at least one. preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, II or IZ injections. In some cases, the composition or the vaccine according to the invention is administered as a single dosage typically in one injection. In the case, where the vaccine according to the invention comprises separate mRNA formulations encoding distinct antigens as defined herein, the minimum number of injections carried out during the administration of a single dosage corresponds to the number of separate components of the vaccine. In certain embodiments, the administration of a single dosage may encompass more than one injection for each component of the vaccine (e.g. a specific mRNA formulation comprising an mRNA encoding, for instance, one antigenic peptide or protein as defined herein). For example, parts of the total volume of an individual component of the vaccine may be injected into different body parts, thus involving more than one injection. In a more specific example, a single dosage of a vaccine comprising four separate mRNA formulations, each of which is administered in two different body parts, comprises eight injections. Typically, a single dosage comprises all injections required to administer all components of the vaccine, wherein a single component may be involve more than one injection as outlined above. In the case, where the administration of a single dosage of the vaccine according to the invention encompasses more than one injection, the injection are carried out essentially simultaneously or concurrently, i.e. typically in a time-staggered fashion within the time-frame that is required for the practitioner to carry out the single injection steps, one after the other. The administration of a single dosage therefore preferably extends over a time period of several minutes, e.g.2, 3, 4, 5, ID, I5, 3D or BO minutes.

5

Administration of the m NA sequence as defined herein, the (pharmaceutical) composition or the vaccine according to the invention may be carried out in a time staggered treatment. A time staggered treatment may be e.g. administration of the mRNA sequence, the composition or the vaccine prior, concurrent and/or subsequent to a conventional therapy of Norovirus infections or diseases or disorders related thereto, e.g. by administration of the mRNA sequence, the composition or the vaccine prior, ID concurrent and/or subsequent to a therapy or an administration of a therapeutic suitable for the treatment or prophylaxis of Norovirus infections or diseases or disorders related thereto. Such time staggered treatment may be carried out using e.g. a kit, preferably a kit of parts as defined herein.

Time staggered treatment may additionally or alternatively also comprise an administration of the mRNA sequence as defined I5 herein, the (pharmaceutical) composition or the vaccine according to the invention in a form, wherein the mRNA encoding an antigenic peptide or protein as defined herein or a fragment or variant thereof, preferably forming part of the composition or the vaccine, is administered parallel, prior or subsequent to another mRNA sequence encoding an antigenic peptide or protein as defined above, preferably forming part of the same inventive composition or vaccine. Preferably, the administration (of all mRNA sequences) occurs within an hour, more preferably within 3D minutes, even more preferably within I5, 10, 5, 4, 3, or 2D minutes or even within I minute. Such time staggered treatment may be carried out using e.g. a kit, preferably a kit of parts as defined herein.

In a preferred embodiment, the pharmaceutical composition or the vaccine of the present invention is administered repeatedly, wherein each administration preferably comprises individual administration of the at least one mRNA of the inventive composition5 or vaccine. At each time point of administration, the at least one mRNA may be administered more than once (e.g.2 or 3 times).

In a particularly preferred embodiment of the invention, at least two, three, four, five, six or more mRNA sequences (each encoding a distinct one of the antigens as defined herein) are administered at each time point, wherein each mRNA is administered twice by injection, distributed over the four limbs. D Kit or kit of parts:

According to another aspect of the present invention, the present invention also provides a kit, in particular a kit of parts, comprising the mRNA sequence as defined herein, the (pharmaceutical) composition, and/or the vaccine according to the invention, optionally a liquid vehicle for solubilising and optionally technical instructions with information on the administration and dosage of the mRNA sequence, the composition and/ or the vaccine. The technical instructions may contain information about5 administration and dosage of the mRNA sequence, the composition and/ or the vaccine. Such kits, preferably kits of parts, may be applied e.g. for any of the above mentioned applications or uses, preferably for the use of the mRNA sequence according to the invention (for the preparation of an inventive medicament, preferably a vaccine) for the treatment or prophylaxis of Norovirus infections or diseases or disorders related thereto. The kits may also be applied for the use of the mRNA sequence, the composition or the vaccine as defined herein (for the preparation of an inventive vaccine) for the treatment or prophylaxis of Norovirus infections or diseases or disorders related thereto, wherein the mRNA sequence, the composition and/Dr the vaccine

5 may be capable of inducing or enhancing an immune response in a mammal as defined above. Such kits may further be applied for the use of the mRNA sequence, the composition or the vaccine as defined herein (for the preparation of an inventive vaccine) for modulating, preferably for eliciting, e.g. to induce or enhance, an immune response in a mammal as defined above, and preferably for supporting treatment or prophylaxis of Norovirus infections or diseases or disorders related thereto. Kits of parts, as a special form of kits, may contain one or more identical or different compositions and/or one or more identical or

ID different vaccines as described herein in different parts of the kit. Kits of parts may also contain an (e.g. one) composition, an (e.g. one) vaccine and/or the mRNA sequence according to the invention in different parts of the kit, e.g. each part of the kit containing an mRNA sequence as defined herein, preferably encoding a distinct antigen. Preferably, the kit or the kit of parts contains as a part a vehicle for solubilising the mRNA according to the invention, the vehicle preferably being Ringer-lactate solution. Any of the above kits may be used in a treatment or prophylaxis as defined above.

I5

In another embodiment of this aspect, the kit according to the present invention may additionally contain at least one adjuvant. In a further embodiment, the kit according to the present invention may additionally contain at least one further pharmaceutically active component, preferably a therapeutic compound suitable for treatment and/ or prophylaxis of cancer or a related disorder. Moreover, in another embodiment, the kit may additionally contain parts and/or devices necessary or suitable for theD administration of the composition or the vaccine according to the invention, including needles, applicators, patches, injection- devices.

Preferred items:

In one embodiment the invention relates to subject matter summarized as follows:

5

Item I. Artificial nucleic acid comprising at least one coding region encoding at least one polypeptide derived from a Norovirus, and/ or a fragment or variant thereof.

Item 2. The artificial nucleic acid according to item I, wherein the at least one encoded polypeptide is selected from the groupD consisting of a non-structural protein derived from a Norovirus and/or a capsid protein derived from a Norovirus, and/or a fragment or variant thereof.

Item 3. The artificial nucleic acid according to item I or 2, wherein the at least one encoded polypeptide is selected from the group consisting of Norovirus non-structural proteins NSI/NS2, NS3, NS4, NS5, NSG, NS7, Norovirus capsid protein VPI and5 Norovirus capsid protein VP2, and/ or a fragment or variant thereof. Item 4. The artificial nucleic acid according to any one of itEms I to 3, wherein the artificial nucleic acid is derived from a Norovirus selected from the group consisting of genogroup I Norovirus. genogroup II Norovirus, genogroup III Norovirus, genogroup IV Norovirus, and genogroup V Norovirus; preferably the artificial nucleic acid is derived from a Norovirus selected from the group consisting of a Gl.l to GI.I7 Norovirus, Gll.l to GII.24 Norovirus, Glll.l to GIII.4 Norovirus, GIV.I to GIV.4 Norovirus and GV.I to GV.4 Norovirus; more preferably, the artificial nucleic acid is derived from a Norovirus selected from the group consisting of Gl.l Norovirus and GII.4 Norovirus, even more preferably, the artificial nucleic acid is derived from a GII.4 Norovirus, still more preferably, the artificial nucleic acid is derived from a GII.4 CIN-I Norovirus or a GII.4 Sydney Norovirus or a GII.4 Sydney 2QI2 Norovirus.

Item 5. The artificial nucleic acid according to any one of items I to 4, wherein the at least one encoded polypeptide comprises at least one Norovirus capsid protein VPI or Norovirus capsid protein VP2 and/or a fragment or a variant thereof.

Item G. The artificial nucleic acid according to any one of items I to 5, wherein the at least one encoded polypeptide comprises at least one Norovirus capsid protein VPI and/or a fragment or variant thereof.

Item 7. The artificial nucleic acid according to any one of items I to G, wherein the at least one encoded polypeptide comprises

(i) at least one of the amino acid sequences according to any one of SEQ ID NDs: I-44I0: and/ or

(ii) at least one of the amino acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 5G%, 57%, 58%, 50%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 68%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 70%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 88%, 30%, 91%, 32%, 93%, 94%, 35%, 96%, 37%, 38%, or 39% sequence identity to the amino acid sequence represented by any one of SEfl I0 NDs: I-44I0; and/or

(iii) an orthologue or a paralogue of any one of SEQ ID NDs: I-39690, 337I3-33746; and/or a fragment or variant of any of these sequences.

Item 8. The artificial nucleic acid according to any one of items I to 7, wherein the at least one coding region comprises

(i) at least one of the nucleic acid sequences according to any one of SEQ ID NDs: 44II-3963D, 337I3-38746; and/ or

(ii) at least one of the nucleic acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 58%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 78%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 88%, 30%, 91%, 32%, 33%, 94%, 35%, 96%, 97%, 98%, or 99% sequence identity to the nucleic acid sequence represented by any one of SED ID NDs: 4411-39690, 38713-33746; and/or

(iii) at least one complement of the nucleic acid sequences which are capable of hybridizing with a nucleic acid sequence comprising a sequence as shown in SED ID NOs: 4411-33680, 33713-30746, and/or to a nucleic acid encoding a polypeptide having a sequence as shown in SEQ ID NDs: 1-4410; and/or (iv) an orthQlogue or a paralogue of any one of SEO ID NOs: I-39690, 397I3-39746; and/ nr a fragment or variant of any of these sequences.

Item 3. The artificial nucleic acid according to any one of items I to 8. wherein the artificial nucleic acid is monocistronic, 5 bicistronic or multicistronic.

Item ID. The artificial nucleic acid according to any one of items I to 9, wherein the artificial nucleic acid is monocistronic and wherein the coding region encodes a polypeptide comprising at least two different Norovirus proteins as defined in any one of items I to 9, or a fragment or variant thereof.

ID

Item II. The artificial nucleic acid according to any one of items I to 9, wherein the artificial nucleic acid is bi- or multicistronic and comprises at least two coding regions, wherein the at least two coding regions encode at least two polypeptides, wherein each of the at least two polypeptides comprises at least one Norovirus protein as defined in any one of items I to 9, or a fragment or variant of any one of these proteins, wherein the at least two polypeptides are preferably different polypeptides.

I5

Item I2. The artificial nucleic acid according to any one of items I to II, wherein the artificial nucleic acid is an NA, preferably an m NA.

Item I3. The artificial nucleic acid according to any one of items I to I2, wherein the artificial nucleic acid comprises a 5'-capD structure.

Item I4. The artificial nucleic acid according to any one of items I to I3, wherein the G/C content of the coding region of the mRNA sequence is increased compared to the G/C content of the corresponding coding sequence of the wild type mRNA, or wherein the C content of the coding region of the mRNA sequence is increased compared to the C content of the corresponding5 coding sequence of the wild type mRNA, or wherein the cndon usage in the coding region of the mRNA sequence is adapted to the human codon usage, or wherein the codon adaptation index (CAI) is increased nr maximised in the coding region of the mRNA sequence, wherein the encoded amino acid sequence of the mRNA sequence is preferably not being modified compared to the encoded amino acid sequence of the wild type mRNA. D Item I5. The artificial nucleic acid according to any one of items I to I4, wherein

(i) the at least one coding region comprises a nucleic acid sequence, which is codon-optimized; and/or

(ii) wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, 60%, 70%, 80%. 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SE0 ID NOs: 8821-13230, 26461-39690, 39715, 39716,5 39717, 3972D, 39721, 39724, 39725, 39728, 39729, 3973D, 39733, 39734, 39737, 39738, 39741, 9742, 39745 and

39746, or a fragment or variant of any of these sequences; and/or (iii) wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, GD%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%. 91%, 92%, 93%, 94%, 95%, 96%. 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEfl ID NDs: I323I-I7640, or a fragment or variant of any of these sequences; and/or

(iv) the artificial nucleic acid according to any one of the preceding items, wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%. 60%, 70%, 80%, 85%. 86%, 87%, 88%, 89%. 90%, 91%, 92%. 93%, 94%. 95%, 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SEfl ID NDs: 17641-22050, or a fragment or variant of any of these sequences; and/or

(v) the artificial nucleic acid according to any one of the preceding items, wherein the at least one coding sequence comprises a nucleic acid sequence, which is identical or at least 50%, 60%, 70%, 80%, 85%, 86%, 87%, 88%, 89%, 90%. 91%. 92%, 93%, 94%, 95%. 96%, 97%, 98%, or 99% identical to a nucleic acid sequence selected from the group consisting of SED ID NDs: 22051-26460, or a fragment or variant of any of these sequences.

Item 16. The artificial nucleic acid according to any one of items I to 15, wherein the artificial nucleic acid comprises at least one histone stem-loop.

Item 17. The artificial nucleic acid according to item 16, wherein the at least one histone stem-loop comprises a nucleic acid sequence according to the following formulae (I) or (II):

formula (I) (stem-loop sequence without stem bordering elements):

[N0-2GN3-5] [No-4(U/T)No-4] [N3-5CN0-2] steml loop stem2 formula (II) (stem-loop sequence with stem bordering elements):

Nl-6 jNo-2GN

^■ γ ₃ No-4(U/T)No-4] | N3-5CNo-2] N1-6

Y - steml steml loop stem2 stem2 bordering element bordering element wherein:

steml or stem2 bordering elements NI-G is a consecutive sequence of I to 6, preferably of 2 to 6, more preferably of 2 to 5, even more preferably of 3 to 5, most preferably of 4 to 5 or 5 N, wherein each N is independently from another selected from a nucleotide selected from A, 0, T, G and C, or a nucleotide analogue thereof; steml [N0-2GN3-5] is reverse complementary or partially reverse complementary with element stem2, and is a consecutive sequence between of 5 to 7 nucleotides; wherein N0-2 is a consecutive sequence of D to 2, preferably of D to I, more preferably of I N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; wherein N3-5 is a consecutive sequence of 3 to 5, preferably of 4 to 5. more preferably of 4 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof, and wherein G is guanosine or an analogue thereof, and may be optionally replaced by a c tidine or an analogue thereof, provided that its complementary nucleotide cytidine in stem2 is replaced by guanosine; loop sequence [No-4(U/T)No-4] is located between elements steml and stem2, and is a consecutive sequence of 3 to 5 nucleotides, more preferably of 4 nucleotides; wherein each N0-4 is independent from another a consecutive sequence of D to 4, preferably of I to 3, more preferably of I to 2 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; and wherein U/T represents uridine, or optionally thymidine; stem2 [N3-5CN0-2] is reverse complementary or partially reverse complementary with element steml, and is a consecutive sequence between of 5 to 7 nucleotides; wherein N3-5 is a consecutive sequence of 3 to 5, preferably of 4 to 5, more preferably of 4 N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; wherein H0-2 is a consecutive sequence of D to 2, preferably of 0 to I, more preferably of I N, wherein each N is independently from another selected from a nucleotide selected from A, U, T, G and C or a nucleotide analogue thereof; and wherein C is cytidine or an analogue thereof, and may be optionally replaced by a guanosine or an analogue thereof provided that its complementary nucleotide guanosine in steml is replaced by cytidine; wherein

steml and stem2 are capable of base pairing with each other forming a reverse complementary sequence, wherein base pairing may occur between steml and stem2, or

forming a partially reverse complementary sequence, wherein an incomplete base pairing may occur between steml and stem2.

Item IS. The artificial nucleic acid according to item I7, wherein the at least one histone stem-loop comprises a nucleic acid sequence according to the fallowing formulae (la) or (Ha);

formula (la) (stem-loop sequence without stem bordering elements):

[N0-1GN3-5] [Ni- ₃ (U/T)No- ₂ ] [N3-5CN0-1] steml loop stem2 formula (Ha) (stem-loop sequence with stem bordering elements):

N2-5 [N0-1GN3-5] [Ni- ₃ (U/T)No-2] [N3-5CN0-1] N2-5 steml steml loop stem2 stem2 bordering element bordering element

Item IB. The artificial nucleic acid according to any one of items IB to 18, wherein the at least one histone stem loop comprises a nucleic acid sequence according to SED 10 NO: 39709 to SED ID NO: 39710, or a fragment or variant thereof.

Item 20. The artificial nucleic acid molecule according to any one of items I to 19, wherein the artificial nucleic acid comprises an untranslated region (UTR).

The artificial nucleic acid according to item 2D. wherein the artificial nucleic acid comprises a 3'-0TR. Item 22. The artificial nucleic acid according to item 2I, wherein the 3'-DTR comprises at least one heterologous 3'-UT element.

Item 23. The artificial nucleic acid according to item 2I or 22, wherein the 3'-UTR comprises a poly(A) sequence and/ or a poly(C) 5 sequence.

Item 24. The artificial nucleic acid according to item 23, wherein the poly(A) sequence comprises ID to 2DD, ID to IDD, 4D to 80 or 50 to 70 adenosine nucleotides, and/or the poly(C) sequence comprises ID to 200, 10 to IDD, 2D to 7D, 2D to BO or ID to 40 cytosine nucleotides.

I0

Item 25. The artificial nucleic acid according to any one of items I to 24, wherein the at least one heterologous 3'-UTR element comprises a nucleic acid sequence derived from a 3'-UTR of a gene, which preferably encodes a stable mRNA, or from a homolog, a fragment or a variant of said gene.

I5 Item 2G. The artificial nucleic acid according to any one of items I to 25, wherein the at least one heterologous 3'-UTR element comprises a nucleic acid sequence derived from a 3'-UTR of a gene selected from the group consisting of an albumin gene, an a-globin gene, a β-globin gene, a tyrosine hydroxylase gene, a lipoxygenase gene, and a collagen alpha gene, or from a homolog, a fragment or a variant thereof. D Item 27. The artificial nucleic acid according to any one of items I to 2B, wherein the at least one heterologous 3'-UTR element comprises a nucleic acid sequence derived from a 3'-DTR of an a-globin gene, preferably comprising the corresponding RNA sequence of the nucleic acid sequence according to SEQ ID NO: 397QI, or SED ID NO: 397D2, a homolog, a fragment, or a variant thereof. 5 Item 28. The artificial nucleic acid according to any one of items I to 27, wherein the at least one heterologous 3'-UTR element comprises a nucleic acid sequence, which is derived from the 3'-UTR of a vertebrate albumin gene or from a variant thereof, preferably from the 3'-DTR of a mammalian albumin gene or from a variant thereof, more preferably from the 3 ^! -UTR of a human albumin gene or from a variant thereof, even more preferably from the 3'-0TR of the human albumin gene according to Genbank Accession number NM_000477.5, or from a fragment or variant thereof.

0

Item 20. The artificial nucleic acid according to any one of items I to 28, wherein the at least one heterologous 3'-UTR element comprises a nucleic acid sequence according to any one of SEQ ID NO: 397D3 to SED ID NO: 39708, or a homolog, a fragment or a variant thereof. 5 Item 30. The artificial nucleic acid according to any one of items I to 29, wherEin the artificial nucleic acid comprises a 5'-0TR. Item 3I. The artificial nucleic acid sequence according to any one of items I to 30, wherein the 5'-UTR comprises at least one heterologous 5'-UTR element.

Item 32. The artificial nucleic acid according to any one of items I to 3I, wherein the at least one heterologous 5'-UTR element comprises a nucleic acid sequence, which is derived from the 5'-UTR of a TOP gene, preferably from a corresponding NA sequence, or a homolog, a fragment, or a variant thereof, preferably lacking the 5'TOP motif.

Item 33. The artificial nucleic acid according to any one of items I to 32, wherein the at least one heterologous 5'-UTR element comprises a nucleic acid sequence, which is derived from a 5'-UTR of a TOP gene encoding a ribosomal protein, preferably from a corresponding RNA sequence, or from a homolog, a fragment or a variant thereof, preferably lacking the 5'TOP motif.

Item 34. The artificial nucleic acid according to any ΟΠΕ of items I to 33, wherein the at least one heterologous 5'-UTR element comprises a nucleic acid sequence, which is derived from a 5'-UTR of a TOP gene encoding a ribosomal Large protein (RPL), preferably RPL32 or RPL35A, or from a gene selected from the group consisting of HSD17B4, ATP5AI, AIGI, ASAHI, CDXBC or ABCB7 (MDR), or from a homolog, a fragment or variant of any one of these genes, preferably lacking the 5'TOP motif.

Item 35. The artificial nucleic acid according to any one of items I to 34, wherein the at least one heterologous 5'-DTR element comprises a nucleic acid sequence according to SED ID HO: 33B9I to SEO ID NO: 39G04, or a homolog, a fragment or a variant thereof.

Item 3B. The artificial nucleic acid according to any one of items I to 35 comprising, preferably in 5' to 3' direction, the following elements:

a) optionally a 5'-cap structure, preferably m7GpppN,

b) a coding region encoding at least one polypeptide derived from a Norovirus as described herein, preferably VPI, or a fragment or variant thereof,

c) optionally a poly(A) tail, preferably consisting of I0 to 20D, ID to IOD, 40 to 80 or 50 to 70 adenosine nucleotides, d) optionally a poly(C) tail, preferably consisting of I0 to 200, 10 to I00, 20 to 7D, 20 to B0 or I0 to 40 cytosine nucleotides, and

e) optionally a histone stem-loop, preferably comprising the RNA sequence according to SEO ID NO: 39700 to SEQ ID NO:

397I0.

Item 37. The artificial nucleic acid according to any one of items I to 3B comprising, preferably in 5' to 3' direction, the following elements:

a) optionally a 5'-cap structure, preferably m7GpppN,

b) a coding region encoding at least one polypeptide derived from a Norovirus, preferably VPI as described herein, or a fragment or variant thereof, c) a S'-LIT Element comprising a nucleic acid sequence, which is derived from an a-globin gene, preferably comprising the corresponding RNA sequence of the nucleic acid SEquence according to SEQ ID NO: 3970I. or SEQ ID NO; 39702, or a homolog, a fragment or a variant thereof,

d) optionally a poly(A) tail, preferably consisting of I0 to 200, 10 to I00, 0 to 80 or 50 to 70 adenosine nucleotides, e) optionally a poly(C) tail, preferably consisting of ID to 200, 10 to I00, 20 to 70, 20 to GO or I0 to 40 cytosine nucleotides, and

f) optionally a histone stem-loop, preferably comprising the RNA sequence according to SEQ I0 NO: 39709 to SEQ ID NO:

397I0.

Item 38. The artificial nucleic acid according to any one of items I to 37, wherein the artificial nucleic acid comprises a nucleic acid sequence according to any one of SEQ ID NO: 397I3-3974B, preferably a nucleic acid sequence according to any one of SEQ ID NO: 397IB, 39721, 39729, 39734, 39738, 39725, or a fragment or variant of any of these sequences.

Item 39. The artificial nucleic acid according to any one of items I to 38, comprising, preferably in 5' to 3' direction, the following elements:

a) optionally a 5'-cap structure, preferably m7GpppN,

b) a 5'-UTR element, which comprises or consists of a nucleic acid sequence, which is derived from the 5'-UTR of a TDP gene, preferably comprising a nucleic acid sequence according to SEQ ID NO: 39G9I, or SEQ ID NO: 39692, or a homolog, a fragment or a variant thereof,

c) a coding region encoding at least one polypeptide derived from a Norovirus, preferably VPI as described herein, or a fragment or variant thereof,

d) a 3'-UTR element comprising a nucleic acid sequence, which is derived from an albumin gene, preferably comprising the corresponding RNA sequence of the nucleic acid sequence according to SEQ ID NO: 39705, or SEQ ID NO: 39706, or a homolog, a fragment or a variant thereof,

e) optionally a poly(A) tail, preferably consisting of I0 to 20D, I0 to I0D, 40 to 80 or 50 to 70 adenosine nucleotides, f) optionally a poly(C) tail, preferably consisting of ID to 2DD, ID to I00, 2D to 70, 0 to B0 or ID to 40 cytosine nucleotides, and

g) optionally a histone stem-loop, preferably comprising the RNA sequEnce according to SEQ ID NO: 39709 to SEQ ID NO:

397I0.

Item 40. The artificial nucleic acid according to any one of items I to 39, wherein the artificial nucleic acid comprises a nucleic acid sequence according to any one of SEQ ID NDs: 397I3-3974B, preferably a nucleic acid sequence according to any one of SEQ ID NOs: 397IB, 39721, 39729. 3B734, 3B738, 39725, or a fragment or variant of any of these sequences.

Item 4I. The artificial nucleic acid according to any one of items I to 40, wherein the coding region comprises a modified nucleic acid sequence. Item 42. The artificial nucleic acid according to any one of items I to 4I, wherein the at least one coding region comprises a nucleic acid sequence encoding a molecular tag and wherein the molecular tag is selected from the group consisting of a FLAB tag, a glutathione-S-transferase (GST) tag, a His tag, a Myc tag, an E tag, a Strep tag, a green fluorescent protein (GFP) tag and 5 an HA tag.

Item 43. Composition comprising at least one artificial nucleic acid as defined by any one of items I to 42 and a pharmaceutically acceptable carrier.

ID Item 44. The composition according to item 43, wherein the at least one m NA is complexed with one or more cationic or polycationic compounds, preferably with cationic or polycationic polymers, cationic or polycatianic peptides or proteins, e.g. protamine, cationic or polycationic polysaccharides and/or cationic or polycationic lipids.

Item 45. The composition according to any one of items 43 to 44. wherein the N/P ratio of the at least one mRNA to the one or I5 more cationic or polycstionic compounds is in the range of about D.I to 2D, including a range of about D.3 to 4, of about D.5 to 2, of about D.7 to 2 and of about D.7 to I.5.

Item 40. The composition according to any one of items 43 to 45 comprising the at least one mRNA, which is complexed with one or more cationic or polycationic compounds, and at least one free mRNA.

D

Item 47. The composition according to any one of items 43 to 46. wherein the at least one complexed mRNA is identical to the at least one free mRNA.

Item 48. The composition according to any one of items 43 to 47, wherein the mRNA is complexed with one or more lipids,5 thereby forming liposomes, lipid nanoparticles and/ or lipoplexes.

Item 49. The composition according to any one of items 43 to 48, wherein the composition comprises at least one adjuvant.

Item 5D. The composition according to any one of items 43 to 49, wherein

D a) the composition comprises a plurality or more than one of the mRNA sequences each defined in any one of items I to

42;

or

b) the composition comprises at least 2, 3, 4, 5, 6.7, 8, 9, ID, II, I2, 13, 14, 15, IB, I7, 18, 19, 20, 21, 22, 23, 24, 5, 2B, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 36. 37, 38, 39, 4D, 41. 42, 43, 44, 45, 40, 47, 48, 49, 50 or more artificial nucleic acids as5 defined by any one of items I to 42, wherein each of the at least 2, 3, 4, 5, 0, 7, 8, 9, ID, II, 12, 13, 14, 15, 16, 17, 18, 19, 20.

21, 22, 3, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 4D, 41, 42, 43, 44, 45, 40, 47, 48, 9, 50 or more artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising a Norovirus protein as defined in any one of items I to 42, and/or a fragment or a variant of any one of these proteins, wherein each coding region preferably encodes a different Norovirus protein, more preferably each coding region encodes a capsid protein, preferably VPI of a different Norovirus.

Item 5I. The composition according to any one of items 43 to 50, wherein

a) wherein each of the mRNA sequences encodes at least one different antigenic peptide or protein derived from proteins of the same Norovirus:

and/or

b) the composition comprises at least 2, 3, 4, 5, B, 7, 8, 9, 10, II, I2, 13, 14, 15, IB, I7, IB, IB, 20, 21 22, 23, 24, 5, 2B, 27, 28, 20, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39. 40, 41, 42, 43, 44, 45, 4B, 47, 48, 49, 50 or more artificial nucleic acids as defined by any one of items I to 42, wherein each of the at least 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14. 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40. 41, 42, 3, 44, 45, 4B, 47, 48, 49, 50 or more artificial nucleic acids comprises at least one coding region encoding at least one polypeptide comprising at least two different Norovirus proteins, preferably VPI and VP2, as defined in any one of items I to 42, and/or a fragment or a variant of any one of these proteins.

Item 52. The composition according to any one of items 43 to 51, wherein the at least one artificial nucleic acid is complexed at least partially with a cationic or polycationic compound and/or a polymeric carrier, preferably a cationic protein or peptide.

Item 53. The composition according to any one of items 43 to 52, wherein

(i) the ratio of complexed nucleic acid to free nucleic acid is selected from a range of about 5:1 (w/w) to about 1:10 (w/w), more preferably from a range of about 4:1 (w/w) to about 1:8 (w/w), even more preferably from a range of about 3:1 (w/w) to about 1:5 (w/w) or 1:3 (w/w), wherein the ratio is most preferably about 1:1 (w/w): or

(ii) the mRNA is complexed with one or more cationic or polycationic compounds in a weight ratio selected from a range of about B:l (w/w) to about 0.25:1 (w/w), more preferably from about 5:1 (w/w) to about 0.5:1 (w/w), even more preferably of about 4:1 (w/w) to about 1:1 (w:w) or of about 3:1 (w/w) to about 1:1 (w/w), and most preferably a ratio of about 3:1 (w/w) to about 2:1 (w/w) of mRNA to cationic or polycationic compound and/or with a polymeric carrier: or optionally in a nitrogen/phosphate ratio of mRNA to cationic or polycationic compound and/or polymeric carrier in the range of about 0.1-10, preferably in a range of about 0.3-4 or 0.3-1, and most preferably in a range of about 0.5-1 or 0.7-1, and even most preferably in a range of about 0.3-0.9 or 0.5-0.9;

and/or wherein the at least one artificial nucleic acid or mRNA is complexed with one or more cationic or polycationic compounds, preferably with cationic or polycationic polymers, cationic or polycationic peptides or proteins, e.g. protamine, cationic or polycationic polysaccharides and/or cationic or polycationic lipids

and/or wherein the at least one artificial nucleic acid or mRNA is complexed with one or more lipids and thereby farming liposomes, lipid nanoparticles and/or lipoplexes. Item 54. The composition according to any one nf items 43 to 53 wherein the composition comprises

(i) at least 2, 3, 4, 5, B, 7, 8. B. ID or more artificial nucleic acids as defined in items I to 42; or

(ii) at least ID, I5, 20 or 50 artificial nucleic acids as defined in items I to 42; or

5 (iii) 2-I0. 10-I5, 15-20, 20-50, 50-100 or I00-200 artificial nucleic acids as defined in items I to 42;

and a pharmaceutically acceptable carrier, wherein preferably the artificial nucleic acid encodes a capsid protein VPI derived from a Norovirus.

Item 55. The composition according to any one of items 43 to 54, wherein

I0 (i) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, I2, 13, 14, 15, IB, I7,

IS, I9, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41, 42, 3, 44, 45. G, 47, 48, 49, 5D or more different Gl Naroviruses; or

(ii) the artificial nucleic acids are derived from a single Gil Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, I2, 13, 14, 15, IB, I7, IS, I9, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33.34, 35, 3B, 37, 38, 39, 0, 41, 2, 43, 44, 5, B, 47, 48, 49, 50

I5 or more different Gil Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gill Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, I2, 13, 14, 15, IB, I7, I8, 19, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41, 42, 43, 4, 45.4B, 47, 48, 9, 50 or more different Gill Noroviruses; or

(iv) the artificial nucleic acids are derived from a single GIV Norovirus or from 2, 3, , 5, G, 7, 8. 9. 10, II, I2, 13, 14, 15, IB, I7.0 IS, I9, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30.31.32, 33. 34, 35, 3B, 37, 38, 39, 40, 41, 2, 43, 4, 45. B.47, 48, 49, 50 or more different GIV Noroviruses; or

(v) the artificial nucleic acids are derived from a single GV Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, ID, II, I2, 13, 14, 15, IB, I7, I8, 19, 20, 21, 22, 23.24.25, 2B, 27, 28, 29, 30, 31, 32, 33, 34.35, 3B, 37, 38, 39.4D, 41, 42, 3, 44, 45, 4B, 47, 48, 9. 50 or more different GV Noroviruses; or

5 (vi) the artificial nucleic acids are derived from a single Gl Norovirus and additionally from a single Gil Norovirus, Gill

Norovirus, GIV Norovirus and/or GV Norovirus; or

(vii) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, , 5, G, 7, 8, 9. ID, II, I2, 13, 14, 15, IB, I7, IB, 19, 2D, 21, 22, 23, 24, 25.2B, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41, 42, 43, 44, 45, 4B, 47, 48, 9, 5D or more different Gl Noroviruses and additionally from a single Gil, Gill, GIV or GV Norovirus and/or from 2, 3, 4, 5, G,D 7, 8, 9, ID, II, 12, 13, 14, 15, IB, 17, 18, 19, 2D, 21.22, 23, 24, 5.2B, 27, 28, 29, 3D, 31. 32. 33. 34. 35, 3B.37, 38, 39, 40.41.

42.43, 44, 45, 4G, 47, 48, 9, 50 and/or more Gil, Gill, GIV or GV Noroviruses;

wherein preferably the artificial nucleic acids encode a capsid protein VPI derived from a Norovirus.

Item 5B. The composition according to any one of items 43 to 55, wherein (i) the artificial nucleic acids are derived from a single Gl.l Narovirus or from 2, 3, 4, 5, G, 7, 8, 0, ID, II. I2, I3, 14, 15, IB, I7, IS, I9, 20, 21, 22, 3, 24, 25, 2G, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44.45, 6, 47, 48, 49, 5D or more different Gl.l Noroviruses; or

(ii) the artificial nucleic acids are derived from a single GII.4 Narovirus or from 2, 3, 4, 5, 6, 7, 8, 9, ID, II, I2, 13, 14, 15, 16, I7, IS, ie, 20, 21, 22, 23, 24.25.26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 6, 47, 48, 49, 50 or more different GII.4 Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gl.l Norovirus and additionally from a single GII.4 Norovirus; or

(iv) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, ID, II, I2, 13, 14, 15, 16, 17, IS, I9, 2D, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 4142, 43, 44.45, 46, 47, 48, 49, 50 or mare different Gl.l Noroviruses and additionally from a single GII.4 Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, 16, 17, IS. 19, 2D, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 4D, 41, 2, 43, 44. 45, 46, 47, 8, 49, 50 or more GII.4 Noroviruses; and/or

wherein

(i) at least one of the nucleic acid sequences according to any one of SE0 ID NO: 39713 to SEfl ID NO: 39746; and/ or

(ii) at least one of the nucleic acid sequences having, in increasing order of preference, at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, 60%, 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%. 69%, 70%, 71%, 72%, 73%, 74%, 75%. 76%, 77%, 78%, 79%, 80%, 81%. 82%. 83%. 84%, 85%, 86%, 87%, 88%. 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity to the nucleic acid sequence represented by any one of SEO ID NO: 39713 to SED ID NO: 39746; and/or

(iii) at least one complement of the nucleic acid sequences which are capable of hybridizing with a nucleic acid sequence comprising a sequence as shown in SEO ID NO: 39713 to SED ID NO: 39746; and/or

(iv) an orthologue or a paralogue of any one of SED ID NO: 39713 to SED ID NO: 39746; and/or a fragment or variant of any of these sequences.

Item 57. Polypeptide encoded by the artificial nucleic acid according to any one of items I to 42.

Item 58. Polypeptide according to any one of items I to 42 comprising at least one protein selected from the group consisting of NSI/NS2, NS3, NS4, NS5, NS6, NS7, VPI, and VP2 derived from Norovirus, ar a fragment or variant of any of these proteins, and at least one amino acid sequence selected from the group consisting of:

a) an amino acid sequence derived from a C-terminal fragment from mature Norovirus capsid protein VPI, or a variant thereof, wherein the C-terminal fragment consists of 3 to 20 amino acid residues,

b) an amino acid sequence derived from a signal sequence of Narovirus capsid protein VPI, or a fragment or variant thereof, and

c) an amino acid sequence derived from an N-terminal fragment from mature Norovirus nan-structural protein NSI/NS2, NS3, NS4, NS5, NS6, or NS7, or a variant thereof, wherein the N-terminal fragment consists of 3 to 20 amino acid residues. item 59. The polypeptide according to any one of items 57 to 58 comprising a molecular tag, wherein the molecular tag is selected from the group consisting of a FLAG tag, a glutathione-S-transferase (GST) tag, a His tag, a Myc tag, an E tag, a Strep tag, a green fluorescent protein (GFP) tag and an HA tag.

Item GD. Composition comprising the polypeptide according to any one of items 57 to 59, and a pharmaceutically acceptable carrier.

Item G!. Vaccine comprising the artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 56, the polypeptide according to any one of items 57 to 59, and/or the composition according to item GD.

Item G2. The vaccine according to item Bl, wherein the artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 5G. the polypeptide according to any one of items 57 to 59. or the composition according to item BD elicits an adaptive immune response.

Item G3. The vaccine according to item Bl to B2, wherein the vaccine further comprises a pharmaceutically acceptable carrier. Item B4. The vaccine according to any one of items Bl to B3 further comprising an adjuvant.

Item B5. The vaccine according to any one of items Gl to B4, wherein the vaccine is multivalent and comprises

(i) at least 2, 3, 4, 5, G. 7, 8, 9, ID or more artificial nucleic acids as defined in items I to 42; or

(ii) at least ID, I5, 2D or 5D artificial nucleic acids as defined in items I to 42; or

(iii) 2-ID. ID-I5, 15-2D, 2D-5D, 5D-I0D or IDD-2DD artificial nucleic acids as defined in items I to 42.

Item 6G. The vaccine according to any one of items Gl to G5, wherein

(i) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, 4, 5, G, 7, 8, 9, ID, II, I2, 13, 14. 15, IG, I7, I8, 19, 2D, 21, 22, 23, 24.25, 26, 27, 28, 29, 3D, 31, 32, 33, 34, 35, 3G, 37, 38, 39, 4D, 41, 2, 43, 44, 45, 4G, 47.48, 49, 5D or more different Gl Noroviruses; or

(ii) the artificial nucleic acids are derived from a single Gil Norovirus or from 2, 3, 4, 5, G, 7, 8, 9, ID, II, I2, 13, !4, 15, 16, 17, I8, 19, 2D, 21, 22, 23, 24, 25, 26, 27, 28, 9, 3D, 3132, 33, 34, 35, 36, 37, 38. 39, 4D, 41, 42, 43, 44, 5, 4G, 47.48, 49, 5D or more different Gil Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gill Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, ID, II, 12, 13, 14, 15, IG, 17, 18, 19, 2D, 21, 22, 23, 24, 25, 26, 7, 28, 29, 3D, 31, 32.33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 4G, 47, 48, 49, 5D or more different Gill Noroviruses; or (iv) the artificial nucleic acids are derived from a single GIV Norovirus or from 2, 3, 4, 5. G, 7. S, 9, IQ, II, I2, 13, 14, I5, IG, I7, IS, I9, 20, 2122, 23, 24, 25, 2G, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3G, 37, 38, 39, 0, 41, 42, 43, 4, 45, 46, 47, 8, 9, 50 or more different GIV Noroviruses; or

(v) the artificial nucleic acids are derived from a single GV Norovirus or from 2, 3, 4, 5, G, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, ie, 20, 21, 22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39.40, 41, 42, 43, 44, 45, 4B, 47, 48, 49, 50 or more different GV Noroviruses; or

(vi) the artificial nucleic acids are derived from a single Gl Norovirus and additionally from a single Gil Norovirus, Gill Norovirus, GIV Norovirus and/or GV Norovirus; or

(vii) the artificial nucleic acids are derived from a single Gl Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, It, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25, 2G, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41, 42, 43, 44, 45, 4B, 47, 8, 49, 50 or more different Gl Noroviruses and additionally from a single Gil, Gill, GIV and/or GV Norovirus or from 2, 3, 4, 5, G, 7. 8, 9, 10. II, 12, 13.14.15, IB, 17, 18, 19, 20.21, 22, 23, 24, 25, 2B, 27, 28, 9, 30, 31, 32, 33, 34, 35. 3B, 37, 38. 39.40, 1, 42, 43, 44, 45, 4B, 47.48, 49, 50 or more Gil, Gill, GIV and/or GV Noroviruses.

Item B7. The vaccine according to any one of items Bl to BB, wherein

(i) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, IG, 17, 18, 19.20, 21, 22, 23, 4, 25, 2B, 27.28, 29, 30, 31.32, 33, 34.35, 3B, 37, 38, 39, 40, 41, 42.43.44.45, 4B, 47, 48, 49, 50 or more different Gl.l Noroviruses; or

(ii) the artificial nucleic acids are derived from a single GII.4 Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10. II, 12, 13, 14, 15, IB, 17, 18.19, 20, 21.22, 23, 24, 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 41.42, 43, 44, 5, 4B, 47, 48, 49, 50 or more different GII.4 Noroviruses; or

(iii) the artificial nucleic acids are derived from a single Gl.l Norovirus and additionally from a single GII.4 Norovirus; or

(iv) the artificial nucleic acids are derived from a single Gl.l Norovirus or from 2, 3, 4, 5, 6, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21, 22, 23, 24, 25.2B, 27, 28, 29, 30. 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40, 1, 42, 3, 4.45. B, 47, 48, 49.50 or more different Gl.l Noroviruses and additionally from a single GII.4 Norovirus or from 2, 3, 4, 5, B, 7, 8, 9, 10, II, 12, 13, 14, 15, IB, 17, 18, 19, 20, 21.22, 23.24. 25, 2B, 27, 28, 29, 30, 31, 32, 33, 34, 35, 3B, 37, 38, 39, 40. 1, 2, 43, 44, 45, 4G, 47, 48.49, 50 or more GII.4 Noroviruses.

Item B8. Kit or kit of parts comprising the artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 5B, the polypeptide according to any one of items 57 to 59, the composition according to item B0 or the vaccine according to any one of items Gl to B7, optionally comprising a liquid vehicle for solubilising, and optionally technical instructions providing information on administration and dosage of the components.

Item B9. The kit or kit of parts according to item B8 comprising Ringer lactate solutioo. Item 7D. The artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 56, the polypeptide according to any one of items 57 to 59, the composition according to item BO, the vaccine according to any one of items Bl to B7, or the kit or kit of parts according to item 68 to B9 for use as a medicament.

5 Item 7I. The artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 5B, the polypeptide according to any one of items 57 to 59, the composition according to item BO, the vaccine according to any one of items Bl to B7, or the kit or kit of parts according to item 68 to B9 for use in the treatment or prophylaxis of an infection with Norovirus or a disorder related to an infection with Norovirus.

ID Item 72. The artificial nucleic acid according to any one of according to any one of items I to 42, the composition according to any one of items 43 to 5B, the polypeptide according to any one of items 57 to 59, the composition according to item BD, the vaccine according to any one of items Bl to 67, or the kit or kit of parts according to item BB to B9, wherein the artificial nucleic acid, the composition, the vaccine or the active component of the kit or kit of parts is administered by injection, preferably by needle-less injection, more preferably by jet injection.

I5

Item 73. The artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 56, the polypeptide according to any one of items 57 to 59, the composition according to item 60, the vaccine according to any one of items Bl to 67, or the kit or kit of parts according to item B8 to 69 for use according to any one of items 70 to 72, wherein the treatment or prophylaxis comprises the administration of a further active pharmaceutical ingredient.

0

Item 74. Method of treating or preventing a disorder, wherein the method comprises administering to a subject in need thereof the artificial nucleic acid according to any one of items I to 42, the composition according to any one of items 43 to 5B, the polypeptide according to any one Df items 57 to 59, the composition according to item BO, the vaccine according to any one of items Bl to 67, or the kit or kit of parts according to item 68 to B9.

5

Item 75. The method according to item 74, wherein the disorder is an infection with Norovirus or a disorder related to an infection with Norovirus.

Brief description of the drawings:

Figure 1: shows that transfectian of HeLa cells with mRNAs coding for Noroviros antigen VPI leads to the expression of the encoded protein. For cell transfection, mRNA constroets (construct ID R2) and (construct ID R4) were used. Norovirus VPI proteins were stained intracellular^ with a specific anti-Norovirus GII.4 antibody and a FITC labelled secondary antibody and analyzed by FACS. A detailed description of the experiment is provided in the examples section, Example 2.

Figure 2: shows that transfection of HeLa cells with mRNAs coding for Norovirus antigen VPI leads to the expression of the encoded protein. For cell transfection, mRNA constructs (construct ID R2FJ), (construct ID R27), and (construct ID R28) were used. Norovirus VPI proteins were stained with a specific anti-Norovirus GII.4 antibody and a FITC labelled secondary antibody and analyzed by FACS. A detailed description of the experiment is provided in the examples section, Example 2.

Figure 3: shows that transfection of HeLa cells with mRNAs coding for Norovirus antigen VPI leads to protein expression. For cell transfection, mRNA constructs (construct ID R2) and (construct ID R4) were used. Western blot analysis was performed cell lysates of transfected cells. As a control, a commercial VLP preparation (Medigen; 50 kD) was osed. Norovirus VPI proteins were stained with a specific anti-Norovirus GII.4 antibody. M= marker lane; 1= mRNA construct R2; 2= mRNA construct R4; 3= WFI control; 4= empty control; 5= commercial VLP control. A detailed description of the experiment is provided in the examples section, Example 3.

Figure 4: shows that immunization of mice with formulated Norovirus mRNA vaccine (Norovirus GC-optimized VP1 X124V; construct ID R4; protamine formulated) induced binding IgGI and lgG2 antibodies, both in a homologous ELISA design (Figure 4A; coating material VLP GII.4) and in a heterologous ELISA design (Figure 4FJ; coating material VLP GII.42011). 1= group vaccinated with Norovirus mRNA vaccine; 2= buffer control group. A detailed description of the experiment is provided in the examples section, Example 4.1.

Figure 5: shows that immunization of mice with formulated Norovirus mRNA vaccine (Norovirus GC-optimized VPIJI24V; construct ID R4; protamine formulated) induced heterologous blocking antibodies. The results of a Histo-Blood Group Antigen (HBGA) assay in serum dilution 1: 12.5 are shown. 1= group vaccinated with Norovirus mRNA vaccine; 2= buffer control group. A detailed description of the experiment is provided in the examples section. Example 4.2.

Figure B: shows that immunization nf mice with formulated Norovirus mRNA vaccine (Norovirus GC-optimized VPI_XI24V; construct ID R4; protamine formulated) induced antigen specific T-cell responses. The results of an ICS assay are shown (CD8+ T-cells). 1= group vaccinated with Norovirus mRNA vaccine; 2= buffer cootrol group. A detailed description of the experiment is provided in the examples section. Example 4.3. Examples:

The Examples shown in the following are merely illustrative and shall describe the present invention in a further way. These Examples shall not be construed to limit the present invention thereto.

5

Example I: Preparation of mRNA for in vitro and in vivo experiments:

I.I. Preparation of ONA and mRNA constructs:

For the present examples. DNA sequences encoding Norovirus antigenic proteins, derived from three or more different Norovirus strains were prepared and used for subsequent RNA in vitro transcription reactions. The prepared RNA constructs (coding ID sequences (cds) and mRNA sequences) are listed in Table 4 below.

Most DNA sequences were prepared by modifying the wild type encoding DNA sequences by introducing a codon modified sequence or GC-optimized sequeoce for stabilization, osing three or more different in silica algorithms that e.g. increase the GC content of the respective coding sequence (indicated as "GC opt I", "GC opt 2". "GC opt 3", "GC opt 4". "opt 5", "opt G". "opt 7" in I5 Table 4: further details relating to sequence modifications are provided in the specifications of the invention). Some DNA sequences were used as a wild type coding sequence, without altering the GC content and without altering the codon usage of the coding sequence (indicated as "wt" in Table 4).

DNA sequences were prepared by modifying the wild type encoding DNA sequences by introducing a GC-optimized sequence forD stabilization, using an in silica algorithms that increase the GC content of the respective coding sequence (e.g., indicated as "opt!" in Table 4, see explanation in the paragraph above).

Moreover, sequences were introduced into a pUCIB derived vector and modified to comprise stabilizing sequences derived from alpha-globin-3'-UTR, a stretch of 3D cytosines. a histone-stem-loop structure, and a stretch of 64 adenosines at the 3'-terminal5 end (poly-A-tail), indicated as "design I" in Table 4. Dther sequences were introduced into a pUCI9 derived vector to comprise stabilizing sequences derived from 32L4 5'-UTR ribnsomal 5'TOP UTR and 3'-UTR derived from albumin 7, a stretch of 3D cytosines, a histone-stam-loop structure, and a stretch of G4 adenosines at the 3'-terminal end (poly-A-tail), indicated as "design 2" in Table 4. Further details are relating mRNA construct design are provided in the specifications of the invention) D The obtained plasmid DNA constructs were transformed and propagated in bacteria {Escherichia coll) using common protocols known in the art. TahlE 4: VPI coding sequences, protein sequences and mRNA constructs

*pratein sequence is back translated into RNA according to the above paragraph "G/C content modification" 1.2. RNA in vitro transcription:

The DNA plasmids prepared according to paragraph I.I were enzymatically linearized using EcoRI and transcribed in vitro using DNA dependent T7 RNA polymerase in the presence of a nucleotide mixture and cap analog (m7GpppG) under suitable buffer conditions. The obtained mRNAs were purified using PureMessenger ⁰ (CureVac, Tubingen. Germany: WD 2DD8/077592 Al) and 5 used for in vitro and in vivo experiments.

1.3. Preparation of protamine formulated RNA vaccine:

The obtained mRNA, e.g. HPLC purified RNA, was complexed with protamine by addition of protamine-trehalose solution to RNA solution at a RNA:protamine weight to weight ratio of 21 Then, complexed RNA was mixed with non-complexed RNA in a ratio of ID 50% free RNA and 50% complexed RNA to obtain formulated RNA. Formulated RNA was used for in M¾7 vaccination experiments.

1.4. Preparation of LNP formulated RNA vaccine:

RNA is encapsulated in lipid nanoparticle (LNP) using established protocols known in the art. Briefly, LNP-encapsulated RNA is prepared using an ionizable amino lipid (cationic lipid), phospholipid, cholesterol and a PEGylated lipid. Cationic lipid, DSPC, 15 cholesterol and PEG-lipid are solubilized in ethanol. RNA is diluted to a total concentration of about D.05 mg/mL in 50 mM citrate buffer pH 4. Syringe pumps are used to mix the ethanolic lipid solution with RNA at a ratio of about l:G to 1:2 (vol/vol). Ethanol is then removed and the external buffer replaced with PBS by dialysis. Lipid nanoparticles are filtered through a D.2 pm pore sterile filter. Lipid nanoparticle particle diameter size may be determined by quasi-elastic light scattering using a Malvern Zetasizer Nano (Malvern, UK).

D

Example 2: Expression of Norovirus VPI antigens in HeLa cells and analysis by FAGS:

To determine in vitro protein expression of the inventive Norovirus mRNA constructs, HeLa cells were transfected with mRNA constructs encoding Norovirus VPI antigens and analyzed by intracellular FACS staining. For cell transfectinn. an mRNA comprising VPIJ124V (GII.4-03I693-USA-2003) wild type coding sequence (SED ID NO: 3B7I4: construct ID R2) an mRNA5 comprising VPIJI24V (GII.4-D3IB33-USA-2D03) GC-optimized coding sequence (SED ID NO: 39716; construct ID R4). an mRNA comprising VPI (GII.4-200Bb 092895-USA-2DD8) GC-optimized coding sequence (SED ID NO: 39729; construct ID R2B), an mRNA comprising VPI (GII.4-GZ20IO-L87-Guangzhou-20ll) GC-optimized coding sequence (SEQ ID NO: 39734; construct R27) and an mRNA comprising VPI NDV(GII.4-OSA-I997)-Capsidprotein GC-optimized coding sequence (SED ID NO: 39738; construct ID R28) were used. The detailed description of the performed experiment is provided below.

D

HeLa cells were seeded in a B-well plate at a density of 4DD.DDD cells/well in cell culture medium (RPMI, 10% FCS, 1% L-Glutamine, 1% Pen/Strep), 24h prior to transfection. Cells were transfected with I pg and 2 pg mRNA per construct using Lipofectamine 2000 (Invitrogen) as transfection reagent. As a negative control, water for injection (WFI) was used. 5 24 hours post transfection, transfected HeLa cells were stained with a commercial mouse anti-Norovirus GII.4 antibody [2000- G5] (Abeam; 1:500) and an anti-mouse FITC labelled secondary antibody (F52B2 from Sigma; 1:500) after Cytofix/Cytoperm (BD Biosciences) treatment according to manufacturer's protocol. Subsequently, cells were analyzed by flow cytometry (FACS) on a FJD FACS Canto II using the FACS Diva software. Quantitative analysis of the fluorescent FITC signal was performed using the FlowJo software package (Tree Star, Inc.). The results of the FACS expression analysis are shown in Figure I and Figure 2.

Results:

Figure I and Figure 2 show that the Norovirus proteins were expressed in HeLa cells transfected with the mRNA constructs R2, R4, R2FJ, R27 and R28. Overall, around 80%-90% of transfected cells showed positive FITC signal, indicating that the inventive constructs tested here were able to efficiently drive protein expression without affecting cell viability. Of note, the data suggests that analogous mRNA constructs encoding other Norovirus VPI or VP2 antigens (as defined in the specifications or listed in Table I and Table 3) may also drive protein expression in a similar manner.

Example 3: Analysis of protein expression using western blot

To determine in vitro protein expression upon HeLa cell transfection with the inventive mRNA constructs, HeLa cells were transiently transfected with an mRNA constructs comprising VPI_XI24V coding sequences. Cell lysates were prepared and analyzed using western blot. The detailed description of the performed experiment is provided below.

HeLa cells are transfected with 2 pg mRNA comprising wild type VPI_XI24V coding sequence (SED ID NO: 3FJ7I4; construct ID R2) and 2 pg mRNA comprising GC-optimized VPI_Xl24V coding sequence (SED ID NO: 337IG; construct ID R4). As a negative control water for injection (WFI) was used. After 24 hours post transfection lysis buffer was added to the culture to prepare cellular lysates. Cellular lysates as well as a commercial Norovirus virus like particle (VLP; obtained from Medigen) were reduced by heating the samples to 95 ^D C for ID minute. Subsequently, samples were subjected to SDS-PAGE under denaturating/reducing conditions followed by western blot detection. For the detection of Norovirus proteins, a commercial mouse anti-Norovirus GII.4 antibody [2D02-G5] (1:250: Abeam) was used as primary antibody followed by secondary goat anti mouse antibody coupled to IRDye 800CW (1:10000; Licor Biosciences). The results of the experiment are shown in Figure 3.

Results:

Figure 3 shows that the Norovirus proteins were expressed in HeLa cells transfected with the inventive mRNA constructs (SEQ ID NOs: 39714 and 397IFJ). Df note, the data suggests that analogous mRNA constructs encoding other Norovirus antigens (as defined in the specifications or listed in Table I and Table 3) may also drive protein expression in a similar manner.

Example 4: Immunization of mice and evaluation of Norovirus specific immune responses

Female BALFJ/c mice were immunized intradermal^ (i.d.) with protamine formulated mRNA vaccine (construct ID R4) with doses, application routes and vaccination schedules as indicated in Table 5. As a negative control, one group of mice was injected with buffer (ringer lactate, RiLa). All animals were vaccinated on day 0, 21 and 35. Blood samples were collected on day 49 for the determination of binding antibody titers (using a homologous and heterologous ELISA assay), blocking antibody titers (using a heteralogDus HGBA assay) and T-cell responses (intracellular cytokine assay). Detailed descriptions of the performed experiments are provided below.

Table 5: Vaccination regimen (Example 4)

4.1. Determination of homologous and heterologous immune responses by ELISA:

ELISA was performed using synthetically produced norovirus Virus like particles (VLP) as coating material. For the analysis of homologous immune responses, plates were coated with VLP of the same strain of genotype BII.4 (GII.4 CINI). For the analysis of heterologous immune responses, plates were coated with VLPs of another strain of genotype GII.4 (GII.4 2011). Coated plates were incubated using respective serum dilutions, and binding of specific antibodies to the Norovirus coating material was detected using biotinylated isotype specific anti-mouse antibodies followed by streptavidin-HRP (horse radish peroxidase) with ABTS as substrate. Endpoint titers of antibodies were measured by ELISA on day 49 after three vaccinations (see Table 5). The results are shown in Figure 4A (homologous responses) and Figure 4B (heterologous responses). 4.2. Determination of blocking antibody titers using a HBGA blocking assay:

Respective sera (day 49 after three vaccinations) were pre-incubated with synthetic norovirus VLPs (VLP (GII.4 2011)) and subsequently added to HBGA coated plates. VLP binding to Histo-Blood Group Antigen (HBGA) was detected by norovirus specific antibodies. In the presence of functional blocking antibodies in serum of immunized animals, VLP binding to HBGA was blocked which results in a reduction of the detected antibody signal. The respective blocking index was calculated as commonly known in the art. The results of the assay are shown in Figure 5.

4.3. Determination of specific CD8 T-cell responses using ICS:

Splenocytes from vaccinated mice were isolated according to a standard protocol known in the art. Briefly, isolated spleens were grinded through a cell strainer and washed in PBS/I%FBS followed by red blood cell lysis. After an extensive washing step with PBS/I%FBS splenocytes were seeded into 96-well plates (2 x I0 ^B cells per well). The cells were stimulated with ten Norovirus CD8 peptide epitopes (lpg/ml of each peptide) in the presence of 2.5 pg/ml of an anti-C028 antibody (BD Biosciences) and anti- CDI07a-PE-Cy7 antibody, after one hour at 37 ^D C. After stimulation, cells were washed and stained and for staining of intracellular cytokines Cytofix/Cytoperm reagent (BD Biosciences) was used according to the manufacturer's instructions. The following antibodies were used for staining: C03-FITC (1:100), CD8-PE-Cy7 (1:200), TNF-PE (1:100), IFNy-APC (1:100) (eBioscience), CD4-BD Horizon V450 (1:200) (B0 Biosciences) and incubated with Fcy-block diluted 1:100. Aqua Dye was used to distinguish live/dead cells (Invitrogen). Cells were acquired using a Canto II flow cytometer (Beckton Dickinson). Flow cytometry data was analyzed using FlowJo software package (ΤΓΒΕ Star, Inc.). Results for CD8+ T-cells are shown in Figure B.

Results:

Figure 4 shows that the tested Norovirus mRNA vaccine induced Norovirus specific IgGI and lgG2 antibody titers in immunized mice. Humoral immune response was demonstrated in a homologous ELISA setting (see Figure 4A) as well as in a heterologous ELISA setting (see Figure 4B). Df note, the observed heterologous humoral immune response (against another strain of genotype GII.4) is of particular importance for a broad protection against Norovirus infections, as GII.4 strains are fast-evolving which is challenging in successful Norovirus vaccine development.

Figure 5 shows that the tested Norovirus mRNA vaccine induced Norovirus specific blocking antibody titers in immunized mice in a homologous and heterologous HGBA assay setup, showing that also functional antibodies were induced after immunization of mice with the inventive Norovirus mRNA vaccine. Of note, the induction of functional blocking antibodies also against another strain of genatype GII.4 demonstrates that the used mRNA Norovirus vaccine may also confer broad protection against different Norovirus strains of genotype GII.4.

Figure B shows that the tested Norovirus mRNA vaccine stimulated a robust CD8+ IFN-y/TNF-α and CD8+ CDI07a/IFN-y in spleen of immunized mice. Overall, the results of the immunization experiments in mice show that the inventive Norovirus mRNA vaccine induced a broad immune response engaging both the humoral-secretory and cellular immunity effector arms. Notably, heterologous immune responses were also observed (ELISA, HGBA). The data suggests that analogous mRNA constructs encoding other Norovirus antigens (as defined in the specifications or listed in Table I or Table 3) may also induce board immune responses in a similar manner.

Example 5: Immunization of mice and further evaluation of heterologous immune responses

Female BALB/c mice are immunized intradermal^ (i.d.) and intramuscularily (i.m.) with protamine formulated or LNP formulated mRNA vaccines with doses, application routes and vaccination schedules as indicated in Table B. As a negative control, one group of mice was injected with buffer (ringer lactate). All animals were vaccinated on day 0, 2I and 35. Blood samples are collected on day 43 for the determination of binding antibody titers (using a homologous and heterologous ELISA assay), blocking antibody titers (using a homologous and heterologous HGBA assay). Detailed descriptions of the performed experiments are provided below. Table G: Vaccination regimen of mice (Example 5)

Group No. of mice Treatment Dose Route/Volume Vaccination schedule

I B Noravirus GC-aptimized VPI 80 pg i.d. dO, dZI. d35

GII.4-USA-IBB7 2x 50 pi

SED ID ND: 30738: R28

Protamine formulated

2 B Norovirus GC-optimized VPI 80 pg i.d. dO, dZI. d35

GII.4-2D06b 092895-DSA-2008 2x 50 pi

SEQ ID NO: 39729; R2G

Protamine formulated

3 B Norovirus GC-optimized VPI 80 pg i.d. dO, d2l. d35

GII.4-GZ20IO-L87-Guangzhou-20ll 2x 50 pi

SED ID NO: 39734; R27

Protamine formulated

4 B Norovirus GC-optimized VPI_XI24V 80 pg i.d. dO, d2l, d35

SEO ID NO: 397IB; R4 2x 50 pi

Protamine formulated

5 G Norovirus GC-optimized VPI 20 pg i.m. d0. d2l. d35

GII.4-USA-I997 2x 25 pi

SEO ID NO: 39738; R28

LNP formulated

B B Norovirus GC-optimized VPI 20 pg i.m. dO. dZI, d35

Gll.4-2006b 092895-USA-2008 2x 25 pi

SEO ID NO: 39729; R2G

LNP formulated

7 B Norovirus GC-optimized VPI 20 pg i.m. dO, dZI. d35

GII.4-GZ20IO-L87-Guangzhou-20ll 2x 25 pi

SEO ID NO: 39734; R27

LNP formulated

8 B Norovirus GC-optimized VPI_XI24V 20 pg i.m. dO. dZI, d35

SEO ID NO: 397IB; R4 2x 25 pi

LNP formulated

9 B 100% RiLa Control i.m. dO. dZI. d35

1x 25 pi 5.I. Determination of homologous and heterologous immune responses by ELISA:

ELISA is performed essentially as described in Example 4.I. Plates are coated with VLP GII.4 CINI and VLP GII.42DII to determine homologous and heterologous immune responses.

5 5.2. Determination of blocking antibody titers using a heterologous HBGA blocking assay:

The HGBA assay is performed essentially as described in Example 4.2.The respective blocking index are calculated as commonly known in the art to evaluate homologous and heterologous cross neutralizing capacities of the used mRNA vaccines.

5.3. Determination of specific CD8 T-cell responses using ICS:

ID Multifunctional C08 T-cell responses are analyzed as described in Example 4.3.

Example B: Norovirus mRNA vaccine challenge study in gnotobiotic pigs

B.I. Immunization of gnotobiotic pigs:

Gnotobiotic pigs are derived by hysterectomy from near-term sows and maintained in germ-free isolator units. Pigs are fed I5 commercial ultra-high-temperature-treated sterile food. All pigs are confirmed as seronegative for Norovirus and germ-free prior to immunization experiments. Gnotobiotic pigs are immunized with protamine formulated or LNP formulated mRNA vaccines (monovalent, bivalent, or tetravalent) with doses, application routes and vaccination schedules as indicated in Table 7. Analysis of immune responses is performed essentially as described in Example 4 (ELISA, HGBA, and ICS). D Table 7: Vaccination regimen of pigs (Example B)

Group No. of pigs Treatment Dose/Route Vaccination schedule

I B Monovalent vaccine; protamine formulated 240 pg dO, d2l

GII.4-2DDBb DB2895-USA-2DD8 i.d.

SED ID ND: 39729; R2B 2x 200 μΙ

2 B Bivalent vaccine; protamine formulated 240 pg dO, dZI

GI.I-USA-l9B8-Capsidprotein (total)

SED ID ND: 39725; R29 i.d.

+ 2x 00 pi

GII.4-GZ20ID-L87-Guangzhou-20ll

SED ID ND: 39734; R27

3 B Tetravalent vaccine; protamine formulated 240 pg d0. d2l

GII.4-USA-I9B7 (total)

SEQ ID NO: 3B73B; R28 i.d.

+ 2x 200 pi

GII.4-D3IG93-USA-2D03

B.2. Norovirus challenge experiment:

At day 30 days post immunization, the vaccinated and buffer-injected control pigs are challenged orally with Norovirus GII.4 (isolated from human stool samples) to assess the protection against Norovirus-induced diarrhea and fecal virus shedding. After virus challenge, rectal swaps and feces samples are collected at day 1, 3, 5, 7 and ID. Norovirus loads in rectal swaps and feces samples are determined using quantitative PCR. In addition, pigs are monitored for Norovirus-associated symptoms and fecal consistence scores are recorded to assess severity of the Norovirus infection. Example 7: Immunization of non-human primates and evaluation of immune responses

Non-human primates (NHPs) are immunized with protamine or LNP formulated mRNA vaccines with doses, application routes and vaccination schedules as indicated in Table 8. Analysis of immune responses is performed essentially as described in Example 4 (ELISA, HGBA, and ICS).

Table 8: Vaccination regimen of NHPs (Example 7)

Group Number of NHPs Treatment Dose/Route Vaccination schedule

I B Monovalent vaccine 240 pg dD, dZI

prntamine formulated i.d.

GH.4-200Gb DB2895-USA-2D08 2x 200 μΙ

SEQ ID NO: 39729; R2B

2 B Bivalent vaccine; 240 pg dD, dZI

protamine formulated (total)

GI.I-USA-l9B8-Capsidprotein i.d.

SE ! ID ND: 39725: R29 2x 200 μΙ

GII.4-GZ2DI0-L87-Guangzhou-2DII

SEQ ID ND: 39734: R27

3 B fetravalent vaccine; protamine formulated 240 pg dO, dZI

GII.4-USA-I397 (total)

SEQ ID ND: 39738: R28 i.d.

+ 2x 200 pi

GII.4-03IB93-USA-2003

SEQ ID ND: 397IB: R4

Gll.4-2006b D92895-USA-2DD8

SEQ ID NO: 39729: R2B

+

GII.4-GZ20ID-L87-Guangzhou-2DII

SEQ ID NO: 39734: R27

4 B Monovalent vaccine; LNP formulated B0 pg dO, dZI

Gll.4-2006b 092895-USA-20D8 i.m.

SEQ ID NO: 39729: R2B 2x 100 pi

5 B Bivalent vaccine; LNP formulated GO pg dD, d2l GIJ-USA-l968-Capsidprotein (total)

SEQ ID NO: 39725: R29 i.m.

+ 2x lOD pi

GII.4-GZ20I0-L87-GuangzhDu-20ll

SEQ ID ND: 39734: R27

B B Tetravalent vaccine; LNP formulated BO pg dD. d2l

GII.4-DSA-I997 (total)

SED ID ND: 39738: R28 i.m.

+ 2x lOD pl

GII.4-D3IB93-DSA-2DD3

SEQ ID ND: 397IB: R4

+

Gll.4-2006b D92895-USA-2DD8

SED ID ND: 39729; R2B

GII.4-GZ20IO-L87-Guangzhou-2DII

SEQ ID ND: 39734; R27

7 B 100% RiLa Control i.m. dD, d2l

Ix IDD pl

Example 8: Development of a multivalent Norovirus mRNA vaccine

8.1. Generation of bivalent, tetravalent and multivalent Norovirus mRNA vaccines

For bivalent and tetravalent Norovirus mRNA vaccines, each mRNA construct is individually produced (as described in Example I).

Multivalent Norovirus vaccine compositions are produced according to procedures as disclosed in the PCT application PCT/EP20IB/D82487. In short, Norovirus DNA constructs (each of which comprising different norovirus coding sequences and a T7 promotor; e.g. synthetic DNA templates immobilized on a chip) are used as a matrix for simultaneous PCR amplification. The obtained PCR product mixture is purified and used as a template for simultaneous RNA in e/Tratranscription to generate a mixture of Norovirus mRNA constructs. The obtained Norovirus mRNA mixture is subjected to quantitative and qualitative measurements (e.g., RNA AGE, RT-qPCR, NGS, and Spectrometry). Following that, purification and formulation is performed (protamine formulation and LNP formulation). For the preparation of multivalent mRNA mixtures, Norovirus sequences as provided in Table 3 (see specifications) are used. The produced bivalent, tetravalent and multivalent Norovirus mRNA vaccines are used for in vitro m& in vivo experiments. 8.2. Expression analysis of multivalent Norovirus mRNA vaccines using quantitative mass spectrometry

Hela cells are transfected with bivalent, tetravalent and multivalent mRNA mixtures (see Table 9) and protein expression is analyzed using quantitative mass spectrometry to show that every mRNA comprised in the respective mRNA mixture is efficiently translated into Norovirus protein/antigen.

8.3. Immunization of mice and evaluation of Norovirus specific immune responses

Female BALB/c mice are with protamine or LNP formulated monovalent, bivalent, tetravalent or multivalent mRNA vaccines with doses, application routes and vaccination schedules as indicated in Table 9. As a negative control, one group of mice is injected with buffer (ringer lactate, RiLa). All animals are vaccinated on day 0, 2I and 35. Blood samples are collected on day 49 for the determination of binding antibody titers (using an ELISA assay), blocking antibody titers (using a HGBA assay) and cellular immune responses (ICS) performed essentially as described in Example 4.

Table 3: Vaccination regimen of mice (Examp

Group Number of mice Treatment Dose/Route Vaccination schedule

I G Monovalent vaccine; Protamine formulated 40 pg dO, d2l, d35

GII.4-D3IG93-USA-20D3 i.d.

SEQ ID NO: 397I6; R4

2 G Bivalent vaccine; Protamine formulated 80 pg dO, dZI. d35

R4 or R2G or R27 or R28 (40 pg each)

+ : I. AD.

R4 or R2B or R27 or R28

3 6 fetravalent vaccine; Protamine formulated 80 pg dO, dZI. d35

GII.4-0SA-I997 (20 pg each)

SED ID ND: 39738; R28 i.d.

+

GII.4-03IG93-USA-2DD3

SEQ ID ND-. 397IG; R4

-f

GII.4-2DD6b 092895-0SA-2DD8

SEQ ID NO: 39729: R2G

+

GII.4-GZ2DID-L87-Guangzhou-20ll

SEQ ID ND: 39734: R27

4 G Bivalent vaccine; Protamine formulated 80 pg dD, d2l, d35

GI.I-USA-l9G8-Capsidprotein (40 pg each) SED ID NO: 39725; R29 i.d.

R4 or R2B or R27 or R28

6 Tetravalent vaccina; Protamine formulated 80 pg dD. dZI. d35

Gl.l-DSA-I968-Capsidpratein (20 pg each)

SED ID NO: 39725; R29 i.d.

GII.4-DSA-I997

SED ID ND; 39738; R28

GII.4-D3IB93-0SA-2D03

SEQ ID NO: 39716: R4

GII.4-2DD6b 0B2895-DSA-2DD8

SED ID NO: 39729; R2G

G Multivalent; Protamine formulated. 80 pg dD. d2l, d35

20 constructs encoding Norovirus antigens of (total) several genogroups, genotypes and strains i.d.

(selected from Table 3).

B Multivalent; Protamine formulated. 80 pg dD. dZI. d35

50 constructs encoding Norovirus aotigens of (total) several genogroups, genotypes and strains i.d.

(selected from Table 3).

B Multivalent; INP formolated. 80 pg dO. dZI. d35

20coostructs encoding Norovirus antigens of (total) several genogroups. genotypes and strains i.m.

(selected from Table 3).

B Multivalent; INP formulated. 80 pg dD. d2l, d35

50 constructs encoding Norovirus antigens of (total) several genogroups, genotypes and strains i.m.

(selected from Table 3).

B 100% RiLa Control - dO. d2l. d35 Example 3: Expression of Norpyirus proteins in HeLa cells and analysis by FACS

To determine in e/rraprotein expression of the constructs, HeLa cells are transiently transfected with mRNA encoding Norovirus antigens and stained using suitable customized anti Norovirus-protein antibodies (raised in mouse) and a FITC-coupled secondary antibody (F52B2 from Sigma).

5

HeLa cells are seeded in a 6-well plate at a density of 4D0D0D cells/well in cell culture medium (RPMI, ID% FCS. I% L-Glutamine, l% Pen/Strep), 24h prior to transfection. HeLa cells are transfected with I and 2 pg unformulated mRHA using Lipofectamine 2D0D (Invitrogen). The mRNA constructs are used in the experiment, including a negative control encoding an irrelevant protein. 24 hours post transfection. HeLa cells are stained with suitable anti Norovirus-protein antibodies (raised in mouse; l:50D) and ID anti-mouse FITC labelled secondary antibody (1:500) and subsequently analyzed by flow cytometry (FACS) on a BD FACS Canto II using the FACS Diva software. Quantitative analysis of the fluorescent FITC signal is performed using the FlowJo software package (Tree Star, Inc.).

Example ID: Expression and secretion of Norovirus proteins using western blot

15 For the analysis of Norovirus protein secretion, HeLa cells are transfected with Ipg and 2pg unformulated mRNA (Rl - R29, see Table 4) including a negative control encoding an irrelevant protein using Lipofectamine as the transfection agent. Supernatants, harvested 24 hours post transfection, are filtered through a 0.2μπι filter. Clarified supernatants are applied on top of I ml 20% sucrose cushion (in PBS) and centrifuged at I4D0D rcf (relative centrifugal force) for 2 hours at 4°C. Norovirus protein content is analyzed by Western Blot suitable customized anti Norovirus-protein antibodies (raised in mouse; 1:500 diluted) as primary0 antibody in combination with secondary anti mouse antibody coupled to IRDye 8D0CW (Licor Biosciences). The presence of αβ- tubulin is also analyzed as control for cellular contamination (αβ-tubulin: Cell Signalling Technology: 1:1000 diluted) in combination with secnndary anti rabbit antibody coupled to IRDye B80RD (Licor Biosciences).

For the analysis of Norovirus proteins in cell lysates, HeLa cells are transfected with Ipg and 2 pg unformulated mRNAs (Rl -5 R29, see Table 4) including a negative control encoding an irrelevant protein using Lipofectamine as the transfection agent 24 hours post transfection, HeLa cells are detached by trypsin-free/EDTA buffer, harvested, and cell lysates are prepared. Cell lysates are subjected to SDS-PAGE under non-denaturating/non-reducting followed by western blot detection. Western Blot analysis is performed using a suitable customized anti Norovirus-protein antibodies antibody (raised in mouse; 1:500 diluted) as primary antibody in combination with secondary anti mouse antibody coupled to IRDye 80DCW (Licor Biosciences).

D

Example II: Preparation of Norovirus vaccine compositions

For in vivo vaccination experiments, different compositions of Norovirus mRNA vaccine are prepared using Norovirus mRNA constructs (see Table 4). Dne composition comprises protamine-complexed mRNA, one composition comprises mRNA that is formulated with an aluminum phosphate adjuvant.

5 111 Preparation nf protamine camplexed mRNA ("vaccine composition I"; RNActive ¹ ):

Norovirus mRNA constructs are complexed with protamine prior to use in in vivo vaccination experiments. The mRNA complexation consists of a mixture of 50% free mRNA and 50% mRNA complexed with protamine at a weight ratio of 21 First, mRNA is complexed with protamine by addition of prntamine-Ringer's lactate solution to mRNA. After incubation far 10 minutes, when the complexes are stably generated, free mRNA is added, and the final concentration of the vaccine is adjusted with Ringer's lactate solution.

11.2. Preparation of mRNA with alum phosphate ("vaccine composition 2"):

mRNA constructs are mixed with the desired amount of aluminum phosphate adjuvant in Ringer's lactate solution ("naked mRNA").

Example 12: Vaccination of mice and evaluation of Norovirus specific immune response

12.1. Immunization

Female BALB/c mice are injected intradermally (i.d.) and intramuscularly (i.m.) with respective mRNA vaccine compositions (prepared according to Example II) with doses, application routes and vaccination schedules as indicated in Table ID. As a negative control, one group of mice is vaccinated with buffer (ringer lactate). All animals are vaccinated on day 1, 21 and 35. Blood samples are collected on day 21, 35, and G3 for the determination of binding and neutralizing antibody titers (see below).

Table ID: Vaccination regimen (Example 12)

Group Number nf mice Vaccine composition Route/Volume Vaccination Schedule (day)

1 10 80 pg Norovirus RNActive ⁰ i. d. 0/21/35

Composition 1 2x 50 pi

2 10 40 pg Norovirus RNActive ⁰ i. d. 0/21/35

Composition 1 2x 50 μΙ

3 10 20 pg Norovirus RNActive ⁰ i. d. 0/21/35

Composition 1 2x 50 pi

4 10 40 pg Norovirus naked RNA i. m. 0/21/35

Composition 2 2x 25 pi

5 10 4D pg Norovirus naked RNA i. m. 0/21/35

Composition 2 2x 25 pi

B 10 40 pg Norovirus naked RNA i. m. 0/21/35

Composition 2 2x 25 pi

7 ID 100% RiLa i. d. 0/21/35

Control 2x 50 pi 12.2. DetBrminatinn of \- Norovirus rotein antibodies by ELISA:

ELISA is performed using inactivated Norovirus infected cell lysate for coating. Coated plates are incubated using respective serum dilutions, and binding of specific antibodies to the Norovirus aniens are detected using biotinylated isotype specific anti- mouse antibodies followed by streptavidin-H P (horse radish peroxidase) with ABTS as substrate. Endpoint titers of antibodies 5 directed against the Norovirus antigens are measured by ELISA on day 63 after three vaccinations.

12.3. Intracellular cytokine staining

Splenocytes from vaccinated mice are isolated according to a standard protocol known in the art. Briefly, isolated spleens are grinded through a cell strainer and washed in PBS/I%FBS followed by red blood cell lysis. After an extensive washing step with

ID PBS/I FBS splenocytes are seeded into FJB-well plates (2 x ID ^G cells per well). The cells are stimulated with a mixture of four Norovirus protein specific peptide epitopes (5pg/ml of each peptide) in the presence of 2.5 pg/ ml of an anti-CD28 antibody (BD Biosciences) for B hours at 37 ^D C in the presence of a protein transport inhibitor. After stimulation, cells are washed and stained for intracellular cytokines using the Cytofix/Cytoperm reagent (BD Biosciences) according to the manufacturer's instructions. The following antibodies are used for staining: CD3-FITC (l:IDD), CD8-PE-Cy7 (l:2DD), TNF-PE (HDD). IFNy-APC (FIDO)

I5 (eBioscience), CD4-BD Horizon V45D (l:2DD) (BD Biosciences) and incubated with Fcy-block diluted 1:10□ . Aqua Dye is used to distinguish live/dead cells (Invitmgen). Cells are acquired using a Canto II flow cytometer (Beckton Dickinson). Flow cytometry data is analyzed using FlowJo software package (Tree Star, Inc.)

12.4. Norovirus plaque reduction neutralization fes^PRNTSO)

D Sera are analyzed by a plaque reduction neutralization test (PRNT50), performed as commonly known in the art. Briefly, obtained serum samples of vaccinated mice are incubated with Norovirus. That mixture is used to infect cultured cells, and the reduction in the number of plaques is determined.

Example 13: Clinical development of a Norovirus mRNA vaccine composition

5 To demonstrate safety and efficiency of the NorovirusnMk vaccine composition, a randomized, double blind, placebo-controlled clinical trial (phase I) is initiated.

For clinical development, GMP-grade RNA is produced using an established GMP process, implementing various quality controls on DNA level and RNA level as described in detail in WO 2DIB/I8D43DAI.

0

In the clinical trial, a cohort of human volunteers is intradermally or intramuscularly injected for at least two times with a monovalent, or a bivalent, or a tetravalent or a multivalent mRNA based Norovirus vaccine as specified herein.

In order to assess the safety profile of the Norovirus vaccine compositions according to the invention, subjects are monitored5 after administration (vital signs, vaccination site tolerability assessments, hematologic analysis). The efficacy of the immunization is analysed by determination of virus neutralizing titers (VNT) or HBGA blocking titers in sera from vaccinated subjects. Blood samples are collected on day D as baseline and after completed vaccination. Sera are analyzed for virus neutralizing antibodies or HBGA blocking antibodies. Furthermore, a subset of subjects is challenged with live Gl.l Norwalk virus or placebo by oral administration. Subjects are followed post-challenge for symptoms of Norovirus associated illness, infection and immune responses. There are multiple clinical assessments and collection of blood, emesis, saliva, and stool specimens.

Table I: Norovirus VPI constructs (row I - row 44IB)

column column column column column column

I 2 3 4 5 6

Raw Name NCBI DP A B C Strain/Isolate

Benbank

Accession

No.

I VPI ABYB535D I 44II 882I, I323I, I7B4I, Z2D5I. norovirus Hu/Duan/Beijing/2006/China

2B4BI, 30871, 3528I

2 VPI ACD55DB8 2 44I2 8822, I3232, I7B42, 22052, norovirus Hu/GII.4/Dijon/E872/2002/FRA

2B4B2, 30872, 35282

3 VPI ADI458D8 3 44I3 8823, I3233, I7B43, 22053, norovirus Hu/GGII.4/Dijon/E3020/2008/FRA

2B4B3, 30873, 35283

4 VPI ADI458II 4 44I4 8824, I3234, I7B44, 22054, norovirus Hu/GGII.4/Dijon/E343B/2D08/FRA

2B4B4, 30874, 35284

5 VPI ADI458I2 5 44I5 8825, I3235, I7B45, 22055, norovirus Hu/GGII.4/Dijon/E3487/20D9/FRA

2B4B5, 30875, 35285

B VPI ADI458I4 B 44IB 882B, I323B, I7B4B, 2205B, norovirus Hu/GGII.4/Dijon/E3G42/2008/FRA

26466, 30876. 3528B

7 VPI ADI458I5 7 44I7 8827, I3237, I7647, 22057, norovirus Hu/GGII.4/Dijon/E3743/2009/FRA

264B7, 30877, 35287

8 VPI ADI458IB 8 44I8 8828, I3238, I7B48, 22058, norovirus Hu/GGII.4/0ijon/E3808/2009/FRA

26468, 30878, 35288

9 VPI A0I458I7 9 44I9 8829, I3239, I7649, 22059, norovirus Hu/GGII.4/0ijon/E3880/2009/FRA

264B9, 30879, 35289

ID VPI ADI458I8 ID 4420 8830, I3240, I7B50, 22060, norovirus Hu/GGII.4/0ijon/E4032/2009/FRA

26470, 30880, 35290 II VPI AET7B29B !l 442I 883I. I324I, I7G5I, 220BI, murine naravirus

2B471, 30881, 3529I

I2 VPI AFBI802B I2 4422 8832. I3242, I7B52, 220B2, murine naravirus

2B472, 30882.35292

I3 VPI AFBI8D27 I3 4423 8833, I3243, I7B53, 220B3, murine naravirus

2B473, 30883, 35293

I4 VPI AFI0823I I4 4424 8834, I3244, I7B54, 220B4, naravirus Hu/Gl/I0360/20IO/VNM

2B474, 30884.35294

I5 VPI AFID824D I5 4425 8835, I3245, I7B55. 220B5, naravirus Hu/GII/IOOI2/2009/VNM

2B475, 30885, 35295

IB VPI AFS33552 IB 442B 8836, I3246, I7B5B, 220BB, naravirus Hu/Gll.4/M0l20-I2/I987/USA

2B47B, 3088B, 3529B

I7 VPI AFS33555 I7 4427 8837, I3247. I7B57, 220B7. naravirus Hu/Bfl.l/7EK/Hawaii/197l/USA

2B477, 30887.35297

I8 VPI AFWI5938 I8 4428 8838. I3248, I7B58, 220B8, narovirus Hu/GII.4/N2/20D8/HuZhou

2B478, 30888, 35298

IB VPI AFWI594D I9 4429 8839, I3249, I7B59, 22069, naravirus Hu/GII.4/N4/2008/HuZhou

2B479, 30889.35299

2D VPI AFWI594I 20 4430 8840, I3250. I7BB0. 22070. naravirus Hu/GII.4/N5/2008/HuZhou

2B480.30890, 35300

2I VPI AFWI5944 2I 443I 884I. I325I, I7BBI. 2207I, narovirus Hu/GII.4/N78/20IO/HuZhau

26481, 30891, 3530I

22 VPI AFWI5947 22 4432 8842. I3252, I7B62, 22072, naravirus Hu/GII.4/N93/20ll/HuZhau

26482, 30892, 35302

23 VPI AFWI5948 23 4433 8843, I3253, I7BB3, 22073, narovirus Hu/GII.4/N94/20ll/HuZhau

26483.30893, 35303

24 VPI AFWI594B 24 4434 8844, I3254. I7664, 22074, narovirus Hu/GII.4/N95 20ll/HuZhau

26484, 30894, 35304

25 VPI AFWI595D 25 4435 8845, I3255, I7665, 22075, narovirus Hu/GII.4/NI00/20ll/HuZhnu

26485, 30895, 35305

2B VPI AFWI595I 2B 443B 8846, I3256, I7666, 22076, narovirus Hu/GII.4/NI0l/20ll/HuZhou

26486, 30896, 35306

27 VPI AFX7IBB5 27 4437 8847, I3257, I7667, 22077, narovirus Hu/Gll.6/CH0C4073/I984/0SA

26487, 30897, 35307 PI AFX7IBG8 28 4438 8848. I3258, I7G68, 22078. narovirus Hu/GII.4/NIHIC9/20ll/USA

2G488, 30898, 353D8

VPI AFX8II2I 29 4439 8849, I3259, I7G69, 22079, narovirus Hu/Narwalk/10034/2009/VNM

26489, 30899, 35309

VP! AFX8II27 30 4440 8850, I32G0, I7G70, 22080, norovirus Hu/Norwalk/10054/2009/VNM

2G490, 30900, 353I0

I VPI AFX8II30 3I 444I 885I, I32GI, I7G7I, 2208I, norovirus Hu/Norwalk/10062/2009/VNM

2G49I.30901, 353II

VPI AFX8II3G 32 4442 8852, I32G2, I7B72, 22082, narovirus Hu/Norwalk/I0075/20D9/VNM

2G492, 30902, 353I2

VPI AFX8II30 33 4443 8853, I32G3, I7G73, 22083, norovirus Hu/Norwalk/10078/2009/VNM

2G493, 30903, 35313

4 VPI AFX8II42 34 4444 8854, I32G4, 17674, 22084. noravirus Hu/Norwalk/10079/2009/VNM

26494, 30904, 35314

5 VPI AFX8II45 35 4445 8855, 13265, 17675, 22085. norovirus Hu/Norwalk/IOIIO/2009/VNM

2G495, 30905.35315

0 VPI AFX8II48 3G 444G 8856, 13266, 17676, 22086, norovirus Hu/Narwaik/IOII4/2009/VNM

26496, 30906, 353IG

7 VPI AFX8II54 37 4447 8857, 13267, 17677, 22087, norovirus Hu/Norwalk/10129/2009/VNM

26497, 30907.35317

8 VPI AFX8II57 38 4448 8858, 13268, I7G78. 22088, norovirus Hu/Norwalk/IOI36/2009/VNM

26498.309D8, 35318

9 VPI AFX8II63 39 4449 8859, 13269, 17679, 22089, norovirus Hu/Norwalk/10145/2009/VNM

26499, 30909, 35319

0 VPI AFX8IIGG 40 4450 8860, 13270, 17680, 22D9D, narovirus Hu/Norwalk/10148/2009/VN

26500.30910, 35320

I VPI AFX8II69 4I 445I 8861, 13271, 17681, 22091. norovirus Hu/Norwalk/10158/2009/VNM

2G501.30911, 35321

2 VPI AFX8II72 42 4452 8862, 13272. 17682, 22092, norovirus Hu/Norwalk/10160/2009/VNM

26502, 30912, 35322

3 VPI AFX8II78 43 4453 8863, 13273, I7G83, 22093, norovirus Hu/Norwalk/IO!G3/2009/VN

2G503, 30913, 35323

4 VPI AFX8II8I 44 4454 8864, 13274, 17684, 22094, norovirus Hu/Norwalk/IOIG9/2009/VNM

26504, 30914, 35324 5 VPI AFX8II9D 45 4455 8865, I3275, I7685, 22095, norovirus Hu/Norwalk/I0f77/2DOS/VNM

26505, 309I5, 35325

G VPI AFX8II93 46 4456 8866, I3276, I7686, 22096, norovirus Hu/Norwalk/IOI79/2009/VNM

26506, 309I6, 35326

7 VPI AFX8II96 47 4457 8867, I3277, I7687, 22097, norovirus Hu/Norwalk/IOI82/2D09/VNM

26507, 309I7, 35327

8 VPI AFX8II9B 48 4458 8868, I3278, I7688, 22098, nDrovirus Hu/Norwalk/IOI83/2009/VN

26508, 3D9I8, 35328

9 VPI AFX8I202 49 4459 8869, I3279, I7689, 22099, norovirus Hu/Norwalk/IOI94/2009/VNM

26509, 309I9, 35329

0 VPI AFX8I205 50 4460 8870, I3280, I7690, 22I00, norovirus Hu/Norwalk/IOI99/2Q09/VNM

265I0, 30920, 35330

I VPI AFX8I208 5! 446I 887I, I328I. I769I, 22I0I, norovirus Hu/Norwalk/10203/2009/VNM

265II, 30B21, 3533I

2 VPI AFX8I2II 52 4462 8872, I3282, I7692, 22ID2, norovirus Hu/Norwalk/10204/2009/VNM

265I2, 30922, 35332

3 VPI AFX8I2I4 53 4463 8873, I3283, I7B93, 22I03, norovirus Hu/Norwalk/10222/2009/VNM

2B5I3.30923, 35333

4 VPI AFX8I226 54 4464 8874, I3284. I7694, 22I04, norovirus Hu/Norwalk/10238/2009/VNM

265I4, 30924, 35334

5 VPI AFX8I229 55 4465 8875, I3285, I7695, 22I05, norovirus Hu/Norwalk/10247/2009/VNM

265I5, 30925.35335

6 VPI AFX8I232 56 4466 887B, I328B, I7B9B, 22IQ6, norovirus Hu/Norwalk/10255/2009/VNM

265IB, 3092B, 35336

7 VPI AFX8I238 57 4467 8877. I3287, I7697, 22I07, norovirus Hu/Norwalk/I029G/20IO/VNM

265I7, 30927, 35337

8 VPI AFX8I24I 58 4468 8878, I3288, I7698, 22I08, norovirus Hu/Norwalk/10313/2010/VNM

265I8, 30928. 35338

9 VPI AFX8I247 59 4469 8879. I3289. I7699, 22I09, norovirus Hu/Norwalk/I0328/2D1D/VNM

265I9, 30929, 35339

0 VPI AFX8I250 60 4470 8880, I3290, I7700, 22II0, norovirus Hu/Norwalk/I03B8/2DIO/VNM

2652D, 30930, 35340

I VPI AFX8I253 6I 447I 888I,I32BI, I770I,22III,2B52I, norovirus Hu/Norwalk/I0378/20ID/VNM

30931, 3534I B2 VPI AFX8I25B B2 4472 8882. I3292, I7702, 22II2. norDvirus Hu/Norwalk/10386/2010/VNM

2B522, 30932.35342

63 VPI AFX8I2B2 B3 4473 8883. I3293, I7703, 22113. noravirus Hu/Norwalk/200IO/2009/VNM

2B523.30933, 35343

B4 VPI AFX8I2B5 B4 4474 8884, 13294, 17704, 22114, noravirus Hu/Norwalk/20014/2009/VNM

2B524, 30B34, 35344

65 VPI AFX8I2B8 B5 4475 8885, 13295, I77D5, 22115. noravirus Hu/Norwalk/200I6/2009/VNM

26525, 30935, 35345

BB VPI AFX8I27I BB 447B 888B, I329B, I770B, 22116. noravirus Hu/Norwalk/200I9/2009/VN

2B52B.3093B.3534B

B7 PI AFX8I274 B7 4477 8887. 13297, 17707, 22117. noravirus Hu/Norwalk/20033/2009/VNM

26527, 30937, 35347

B8 VPI AFX8I277 B8 4478 8888, 13298, 17708, 22118, noravirus Hu/Norwalk/20025/2009/VNM

2G528, 30938, 35348

B9 VPI AFX8I283 B9 4479 8889, 13299, 17709, 22119, noravirus Hu/Norwalk/2D 047/2009/VNM

2G529, 30939, 35349

70 VPI AFX8I289 70 4480 8890, 13300, 17710, 22120, noravirus Hu/Norwalk/20067/2009/VNM

26530.30940, 35350

7I VPI AFX8I292 7I 448I 8891, 13301, 17711, 22121, noravirus Hu/Norwalk/2006B/2009/VNM

2B531, 30041, 35351

72 VPI AFX8I295 72 4482 8892, 13302, 17712. 22122, norovirus Hu/Norwalk/20092/2009/VNM

2B532, 30942, 35352

73 VPI AFX8I298 73 4483 8893, 13303, 17713, 22123, noravirus Hu/Norwalk/20093/2009/VNM

26533, 30943, 35353

74 VPI AFX8I30I 74 4484 8894, 13304, 17714, 22124, noravirus Hu/Norwalk/20094/2009/VNM

2B534, 30944. 35354

75 VPI AFX8I3D4 75 4485 8895, 13305, 17715, 22125, noravirus Hu/Norwalk/20II8/2009/VNM

2B535, 30945, 35355

7B VPI AFX8I307 7B 448B 8896, 13306. 17716, 22I2B, noravirus Hu/Norwalk/20122/2009/VNM

2B53B, 30946, 35356

77 VPI AFX8I3I3 77 4487 8897, 13307, 17717, 22127, noravirus Hu/Norwalk/20128/2009/VNM

26537, 30947, 35357

78 VPI AFX8I3IB 78 4488 8898, 13308. 17718. 22128, noravirus Hu/Norwalk/20I35/2009/VNM

2B538, 30948, 35358 79 VPI AFX8I3I9 79 4489 8899, 13300, 17719, 22129, naravirus Hu/Norwalk/20139/2009/VNM

2B533, 30949, 35359

8D VPI AFX8I322 8D 4490 8900, 13310, 17720, 22130, norovirus Hu/Norwalk/20l40/200e/VNM

2B540, 30950, 353B0

8I VPI AFX8I325 8I 4491 8901, 13311,17721, 22131, 2B54I, norovirus Hu/Norwalk/20142/2009/VNM

30951, 353BI

82 VPI AGE89433 82 4492 8902, 13312, 17722. 22132, norovirus Hu/GII/IOIOI/2009/VNM

2B542, 30352, 353B2

83 VPI AGE8943B 83 4493 8903, 13313, 17723, 22133, norovirus Hu/GII/10127/2009/VNM

2B543, 30953, 353B3

84 VPI AGE89439 84 4494 8904, 13314, 17724, 22134, norovirus Hu/GII/10370/2010/VNM

2B544, 30954, 353B4

85 VPI AGE89442 85 4495 8905, 13315, 17725, 22135, norovirus Hu/Gll/I0405/20I0/VNM

2B545, 30955, 353B5

8B VPI AGE89445 8B 449B 890B, 13316. I772B. 22I3B, norovirus Hu/GII/IO4OG/2OI0/VNM

2B54B, 3095G, 353BB

87 VPI AGE89448 87 4497 8907, 13317, 17727, 22137, norovirus Hu/Gll/I04ll/20I0/VNM

2B547, 30957, 353B7

88 VPI AGE8945I 88 4498 8908, 13318, 17728, 22138, norovirus Hu/GII/10420/2010/VNM

2B548, 30958, 353B8

8B VPI AGE89454 89 4499 8909, 13319, 17729, 22139, norovirus Hu/GII/20048/2009/VNM

2B549, 30959, 353B9

90 VPI AGE89457 90 4500 8910, 13320, 17730, 22140, norovirus Hu/GII/200B4/2009/VNM

2B550.309BQ, 35370

9I VPI AGE894B0 91 4501 8911, 13321, 17731, 22141, 2B55I, norovirus Hu/GII/20079/2009/VNM

309BI, 35371

92 VPI AGE894B3 92 4502 8912, 13322. 17732, 22142, norovirus Hu/BII/20107/2009/VNM

2B552.309B2, 35372

93 VPI AGE894GB 93 4503 8313. 13323, 17733, 22143, norovirus Hu/GII/20108/2009/VNM

2B553, 309B3, 35373

94 VPI AGE89472 94 4504 8914, 13324, 17734, 22144, norovirus Hu/GII/20l4B/2009/VNM

2B554, 309B4, 35374

95 VPI AGE89475 95 4505 8915, 13325. 17735, 22145, norovirus Hu/GII/20150/2009/VNM

2B555, 309B5, 35375 BB VPI AGE83478 3B 450B 89IB, I332B. I773B, 22I4B. norovirus Hu/GII/20151/2009/VNM

2B55B, 3D9BB, 3537B

37 VPI AGE8848I 37 45D7 89I7, I3327. I7737, 22I47, norovirus Hu/GII/2DI53/2009/VNM

2B557.3Q967.35377

98 PI AGE83490 38 4508 89I8, I3328. I7738. 22I48. norovirus Hu/GII/20159/2009/VNM

2B558.303B8, 35378

39 VPI AGE89493 33 4509 8BI3, I3323. I773B. 22I49. norovirus Hu/Gll/20I6I/200B/VNM

26553, 3D9BB.35379

IDD VPI AGE8949B I00 45I0 8323. I333D, I7740, 22I5D, norovirus Hu/GII/20IB2/2009/VNM

2B5B0, 30S70, 35380

IOI VPI AGE83433 IOI 45II 892I, 13331. 17741, 22151, norovirus Hu/GII/20IG4/2009/VNM

2B5BI, 30371, 35381

I02 VPI AGE83502 I02 45I2 8322, 13332, 17742, 22152, norovirus Hu/GII/2DI7l/2009/VNM

2B5B2, 30372, 35382

I03 VPI AGE895D5 ID3 45I3 8323, 13333, 17743, 22153, norovirus Hu/GII/20172/2009/VNM

2B5B3, 30373, 35383

I04 VPI ABE89508 I04 45I4 8324, 13334, 17744, 22154, norovirus Hu/GII/20173/2009/VNM

26564, 30974, 35384

I05 VPI AGE895II I05 45I5 8325, 13335, 17745, 22155, norovirus Hu/GII/2DI76/2009/VNM

26565, 30375, 35385

IDE VPI AGE835I4 IOB 45IB 8326, I333B, I774B, 22I5B, norovirus Hu/GII/20180/2009/VNM

2656B, 30976, 35386

ID7 VPI AGE835I7 I07 45I7 8927, 13337, 17747, 22157, norovirus Hu/GII/20182/2009/VNM

26567, 30977. 35387

IDS VPI AGE89520 I08 45I8 8928, 13338, 17748, 22158, norovirus Hu/Gll/20184/2009/VNM

26568, 3D978.35388

ID3 VPI AGE83523 IDS 45I9 8923, 13333, 17743, 22153. norovirus Hu/GII/2DI85/2009/VNM

2B5B3, 3D97B, 35383

HO VPI AGE8352B HO 452D 893D, 13340, I775D, 22160, norovirus Hu/GII/20187/2009/VNM

26570, 30380, 35390

III VPI AGE89529 III 452I 8931, 13341, 17751, 22161, norovirus Hu/Gll/20I89/2B09/VNM

26571, 30381. 35331

II2 VPI AGE89532 II2 4522 8332. 13342, 17752, 22IB2, norovirus Hu/GII/20l3D/2009/VNM

26572, 3D382, 35332 II3 VPI AGE89535 113 4523 8933, 13343, 17753, 22163, norovirus Hu/GII/20192/2009/VN

26573. 30983, 35393

II4 VPI AGE89538 114 4524 8934. 13344. 17754, 22164, norovirus Hu/Gll/20I9G/2D09/VNM

26574, 30984, 35394

tl5 VPI AGE8954I 115 4525 8935, 13345, 17755, 221B5, norovirus Hu/GII/20198/2009/VNM

26575, 30985, 35395

IIG VPI AGE89544 116 4526 8936, 13346, 17756, 22IB6, norovirus Hu/GII/20202/2009/VNM

26576, 30986, 3539B

117 VPI AGE89547 117 4527 8937, 13347, 17757, 22IB7, norovirus Hu/GII/20205/2009/VNM

26577, 30987, 35397

118 VPI AGE8955D 118 4528 8938, 13348, 17758, 22168, norovirus Hu/GII/20206/2009/VNM

26578, 30988, 35398

119 VPI AGE89553 119 4529 8939, 13349, 17759, 22IB9, norovirus Hu/GII/20208/2009/VNM

2B579, 30989, 35399

I2D VPI AGE89556 120 4530 8940, 13350, 17760, 22170. norovirus Hu/Gll/202I5/20D9/VNM

26580. 30990, 35400

121 VPI AGE89559 121 4531 8941. 13351. 17761, 22171, norovirus Hu/GII/20217/2009/VNM

26581, 30991, 35401

122 PI AGE895G2 122 4532 8942, 13352, I77B2, 22172, norovirus Hu/GII/20229/2009/VNM

26582, 30992, 35402

123 VPI AGE895B5 123 4533 8943, 13353, 17763, 22173, norovirus Hu/GII/20230/2009/VNM

26583, 3D993, 35403

124 VPI AGE895B8 124 4534 8944, 13354, 17764, 22174, norovirus Hu/GII/20233/2009/VNM

26584, 30994, 35404

125 VPI AGE8957I 125 4535 8945, 13355, 17765. 22175, norovirus Hu/GII/20248/2009/VNM

26585, 30995, 354D5

126 VPI AGE89574 I2B 453B 8948. I335B, I77BB, 22I7B, norovirus Hu/GII/20258/2009/VN

2658B, 30996, 35406

127 VPI AGE89577 127 4537 8947, 13357, I77B7, 22177, norovirus Hu/GII/20263/2009/VNM

2B587, 30997, 35407

128 VPI AGE8958D 128 4538 8948, 13358, I77B8, 22178, norovirus Hu/GII/2027l/2009/VN

26588, 30998, 35408

129 VPI AGE89583 129 4539 8949, 13359, I77B9, 22179, norovirus Hu/GII/20276/2009/VNM

2B589, 30999, 35409 I3D VPI AGE8B58B I3D 4540 8950, I33B0, I7770, 22I80, narovirus Hu/GII/20302/2009/VNM

2B590, 3I000, 354I0

I3I PI AGE89589 I3I 454I 895I, I33BI, I777I, 22181. norovirus Hu/GII/20344/2009/VNM

26591. 31001, 35411

I32 VPI AGE89592 I32 4542 8952, I33B2, 17772, 22182, norovirus Hu/GII/20350/2009/VNM

2B592, 3I0D2, 35412

I33 VP! AGE89595 I33 4543 8953, I33B3, 17773, 22183, norovirus Hu/GII/20357/2009/VNM

2B593, 31003, 35413

I34 VPI AGE89598 I34 4544 8954, I33B4, 17774, 22184, norovirus Hu/GII/20365/2010/VNM

26594, 31004, 35414

I35 VPI AGE89GDI I35 4545 8955, 13365, 17775, 22185, norovirus Hu/GII/20373/2010/VNM

2B595, 31005, 35415

I3B VPI AGE89BD4 I3B 454B 8956, 13366, 17776, 22I8B, norovirus Hu/GII/20407/20ID/VNM

2B596, 3I00B, 354IB

I37 VPI AGE89B07 I37 4547 8957, I33B7, 17777, 22187, norovirus Hu/Gll/204I3/20I0/VNM

26597, 31007, 35417

I38 VPI AGE89BI0 I38 4548 8958, 13368, 17778, 22188, norovirus Hu/GII/20424/2010/VNM

2B598, 31008, 35418

139 VPI AGE89GI3 I39 4549 8959, 13369, 17779, 22189, norovirus Hu/GII/20448/2010/VNM

2B599, 31009, 35419

I40 VPI AGE89BIB I40 4550 8960, 13370, 17780, 22190, norovirus Hu/GII/2D457/20ID/VNM

2BB00, 31010, 35420

I4I VPI AGE89B22 I4I 455I 8961, 13371, 17781, 22191, norovirus Hu/GII/20469/20IQ/VNM

26601, 31011. 35421

I42 VPI AGE89B25 I42 4552 8962, 13372, 17782, 22192, norovirus Hu/Gll/2D477/20I0/VNM

26602, 3IDI2, 35422

I43 VPI AGE89B28 I43 4553 8963, 13373, 17783, 22193. norovirus Hu/GII/20478/20IQ/VNM

26B03.31013, 35423

I44 VPI AGE89B3I I44 4554 8964. 13374, 17784, 22194, norovirus Hu/Gll/300I7/20D9/VNM

26604, 31014.35424

I45 VPI AGE89B34 I45 4555 8965. 13375, 17785, 22195, norovirus Hu/GII/3002B/2009/VNM

26605, 31015, 35425

I4B VPI AGE89B37 I4B 455B 8966, 13376, 17786, 22196, norovirus Hu/GII/30040/2009/VNM

26606, 31016, 3542B I47 VPI ABE8BB4D I47 4557 83B7, I3377, I7787, 22I37, norovirus Hu/GII/30045/2009/VNM

2BB07, 3I0I7, 35427

I48 VPI AGE83B43 I48 4558 89B8. I3378, I7788, 22I38. naravirus Hu/Gll/30II2/2009/VNM

2BB08, 3I0I8, 35428

I49 VPI AGE83B4B I43 4553 83S3. I3373. I7783. 22I33, naravirus Hu/GII/30113/2008/VNM

2GG03, 3I0I3.35429

I5D VPI AGE89B43 I50 45BD 8S70, I3380, I7730, 22200, naravirus Hu/GII/30129/2009/VNM

2BBI0, 3I020, 35430

I5I VPI AGE8S652 I5I 45BI 837I, I338I, 17731. 22201, naravirus Hu/GII/30133/2009/VNM

2BBII, 31021, 35431

I5Z VPI AGE89655 I52 45G2 8372, 13382, 17732, 22202. naravirus Hu/GII/3020l/2B09/VNM

2BBI2, 3ID22, 35432

I53 VPI AGE83B58 I53 45B3 8373, 13383, 17733, 22203, naravirus Hu/GII/3020G/2009/VN

2BBI3, 31023, 35433

I54 VPI AGE83BBI I54 45B4 8374, 13384, 17794, 22204, norovirus Hu/GII/30207/2003/VNM

2BBI4, 31024. 35434

I55 VPI AGE83BB4 I55 45B5 8375, 13385, 17735, 22205, naravirus Hu/GII/302tl/2009/VNM

2BBI5, 3ID25, 35435

I5B VPI AGE83BB7 I5B 45BB 8376. I338B. 17736, 2220B, naravirus Hu/GII/30212/2009/VNM

2BBIB, 31026, 35436

I57 VPI AGE83B73 I57 45B7 8377, 13387, 17797, 22207, naravirus Hu/GII/30266/2003/VNM

26BI7, 31027, 35437

I58 VPI AGE33BD3 I58 45B8 8978, 13388, 17798, 22208. naravirus Hu/GII.4/NIHIC4.l/20ll/USA

2BBI8, 31028, 35438

I5B VPI AGII7592 I53 4563 8979, 13389, 17793, 22203, naravirus Hu/GII.I7/CI42/l978/GUE

26613, 31023.35433

IBD VPI AGII7534 IBO 4570 8380, I33B0. 17800, 22210, norovirus Hu/GII.3/NIHIC8.l/20ll/USA

26620, 31030, 35440

I6l VPI AG 3B3II IBI 457I 8381, 13331, 17801, 22211, norovirus Hu/Gll.4/20I99/2009/VNM

26621, 31031, 35441

IBZ VPI AGK3G3I4 IB2 4572 8382, 13392, 17802, 22212, norovirus Hu/GII.4/20406/20IO/VNM

26622, 31032, 35442

IB3 VPI AGM332D8 IB3 4573 8883, 13333, 17803, 22213, naravirus Hu/GI.I/CHA7A009/20IO/USA

26623, 31033, 35443 IB4 VPl AGM332I4 IB4 4574 8984. I3394, I7804, 222I4. narovirus

2BB24.31034, 35444 Hu/Gl.l/CHA6A003_2009I028/2QQ9/OSA

IB5 VPl AGM332I7 IB5 4575 8985, 13395, 17805, 22215. n _D rovirus Hu/GI.I/CHA2AOI4/20D8/USA

2BB25, 31035, 35445

IBB VPl AGM3322D IBB 457B 898B. I339G, I780B, 222IB, narovirus Hu/GI.I/CHABA007/2DID/USA

2BB2B, 3I03B, 3544B

IB7 Pl AGM3322G IB7 4577 8987, 13397, 17807, 22217, nornvirus Hu/GI.I/CH4X0533/2009/USA

2BB27, 31037, 35447

IB8 Pl AGM3322B IB8 4578 8988, 13398, 17808, 22218, norovirus Hu/GI.I/CHA5AOIO/20Q9/USA

2BB28, 31038, 35448

IB9 VPl AGM33232 IB9 4579 8989, 13399, I78D9. 22219, naravirus

2BB29, 31039, 35449 Hu/GIJ/CHA9A004_20ll042B/20ll/USA

I70 VPl AGM33235 I7D 4580 8990, 13400, 17810. 22220, norovirus Hu/GI.I/Cr!AEAQI4/2009/USA

2BB30, 31040, 3545D

I7I VPl AGM33238 I7I 458I 8991. 13401, 17811, 22221, naravirus Hu/GI.I/CHA3A007/2008/USA

2GB31, 31041, 35451

I72 VPl AG 3324I I72 4582 8992, 13402, 17812, 22222, naravirus Hu/Gl.l/CHA7A0II/20I0/USA

2BB32, 31042, 35452

I73 VPl AG 33244 I73 4583 8993, 13403, 17813, 22223. naravirus

2BB33, 31043, 35453 Hu/Gl.l/CHABA003_2009II04/2009/OSA

I74 VPl AGQ59890 I74 4584 8994, 13404, 17814, 22224, murine naravirus 1

2BB34, 3ID44, 35454

I75 VPl AGTI7782 I75 4585 8995, 13405, 17815, 22225, naravirus Hu/GII.4/NIHIC28.4/2OI2/0SA

2BB35, 31045, 35455

I7B VPl AGTI7785 I7G 458B 899B, I340B, 17816. 2222B, narovirus Hu/GI,l/8 alllL/l972/USA

2BB3B. 3I04B, 3545B

I77 VPl AGTI7788 I77 4587 8997, 13407. 17817, 22227, narovirus Hu/GII.4/NIHICI7.7/ZDI2/USA

2GB37, 31047, 35457

I78 Pl AGTI7792 I78 4588 8998, 13408, 17818, 22228, naravirus Hu/Gi,l/8W/I9G8/USA

2BB38, 31048, 35458

I79 VPl AGTI7795 I79 4589 8999, 13409, 17819, 22229, narovirus Hu/GII.4/NIHICI3/20ll/USA

2BG39, 31049, 35459

I8D VPl AGTI7798 ISO 4590 9000, 13410, 17820, 22230, naravirus Hu/Gll.4/NIHICI.I3/20I2/USA

2BB40, 31050, 354B0 I8I VPI AGTI78B3 I8I 459I 30DI, I34II. I782I, 2223I, norovirus Hu/Gl.f/8 cill/ig73/USA

2BB41, 3IQ51.354BI

I82 VPI AGTI780B I82 4532 3DB2, I34I2. I7822, 22232, norovirus Hu/GI.I/8C IIIc/l974/USA

2BB42, 3ID52, 354B2

I83 VPI ABTI78D9 I83 4533 30D3, I34I3, I7823, 22233, norovirus Hu/GI.I/8Ulllf/ie73/USA

2BB43, 3I053, 354B3

I84 VPI AGTI78I3 I84 4534 3004, I34I4, I7824, 22234, norovirus Hu/GII.4/NIHICI7.l/Z0IZ/USA

2BB44, 3I054, 354B4

I85 VPI AGTI78IB I85 4535 9005, I34I5, I7825, 22235, norovirus Hu/Gll.4/NIHIC27.I/20I2/USA

2BB45, 3I055, 354B5

IBB VPI AGTI78IB IBB 4536 900B, I34IB, I782B, 2223B, norovirus Hu/Gll.4/NIHICI8,I/20I2/0SA

2BB4B, 3ID5B, 354BB

I87 VPI AGTI7823 I87 4537 9007, 13417. 17827, 22237, norovirus Hu/GII.4/NIHICI.3/20IO/OSA

2BB47, 31057, 354B7

I88 VPI AGTI782G I88 4598 9008, 13418, 17828, 22238, norovirus Hu/Gl.l/8K/I979/USA

2BB48, 31058, 354B8

I89 VPI AGTI7830 I83 4599 3003, 13413, 17823, 22233, norovirus Hu/GII.4/NIHIC28.5/2OI2/0SA

2BB43, 31053, 354B9

I90 VPI AGTI7833 ISO 4B00 3010, 13420, 17830, 22240, norovirus Hu/Gll.4/NIHIC20/20I2/0SA

2BB5D, 3IDB0, 35470

IBI VPI AGTI783B IBI 4BBI 3011, 13421, 17831, 22241, norovirus Hu/Gl.l/8MC/I978/USA

2BB51, 31061.35471

I92 VPI AGTI7842 I92 4GD2 3012. 13422, 17832, 22242, norovirus Hu/GII.4/NIHICI.5/ZDII/USA

2BB52, 3I0B2, 35472

I93 VPI AGUB8328 I93 4BD3 3013, 13423, 17833, 22243, norovirus PAI3/20I3/ITA

2BB53, 3I0B3, 35473

I34 VPI AGX8588B I94 4BB4 3014, 13424, 17834, 22244, norovirus Hu/Gll.4/NIHICI.8/20I2/USA

2BB54, 3I0B4, 35474

I95 VPI AGX85892 I95 4GD5 3015, 13425, 17835, 22245, norovirus Hu/GII.4/NIHICI.I0/2DI2/USA

2BB55, 3I0B5, 35475

IBB VPI AGX85895 I9B 4B0B 30IB, I342B, I783B, 2224B, norovirus Hu/Gll.4/NIHICI.7/20I2/USA

2BB5B, 3I0BB, 3547B

I97 VPI AGX85904 I37 4B07 3017, 13427, 17837, 22247, norovirus Hu/GII.4/NIHIC27.2/2DI2/USA

26657.3I0B7, 35477 I98 VPI AGX859I3 I98 4BD8 90I8, I3428, I7838. 22248. norovirus Hu/Gll.4/NIHICI.I4/20I2/USA

2BB58, 3I0B8. 35478

I89 VPI AGX859IB I99 4B09 90I9, I3429, I7839. 22249, norovirus Hu/Gll.4/NIHICI7.6/20I2/USA

26659, 3I0B9, 35479

200 VPI AGX8593I 200 4BI0 9020, I3430, I7840, 22250, norovirus Hu/GII.4/NIHICI.I2/2DI2/USA

2BBB0, 3I07D, 3548D

20I VPI AGX85934 20I 4BII 902I, I343I, I784I, 2225I, norovirus Hu/Gll.4/NIHICI.II/20I2/USA

266BI, 3I071, 3548I

202 VPI AHI59I54 202 4BI2 9022, I3432, I7842, 22252, narovirus Hu/GII.6/HS245/20IO/USA

26662, 31072. 35482

203 VPI AHI59I57 203 4BI3 9023. 13433, 17843, 22253. norovirus Hu/GII.4/HS232 2DIZ/USA

266B3, 31073.35483

204 VPI AHI59I59 204 4BI4 9024, 13434. 17844. 22254, narovirus Hu/GII.2/HS255/20ll/USA

2BBB4, 31074, 35484

205 VPI AHK24788 205 4BI5 9025, 13435, 17845, 22255, murine norovirus

2BB65.31075, 35485

20B VP! AHX220I8 20B 4BIB 9026, 13436, 17846, 22256, norovirus Hu/Gll/BGIC0434/20I2/BGD

266B6. 31076, 35486

207 VPI AHX2202I 207 4BI7 9027, 13437. 17847, 22257, narovirus Hu/GII/BGIC0204/20ll/BGD

26667, 31077. 35487

2D8 VPI AHX22025 208 4BI8 9028. 13438, 17848, 22258, norovirus Hu/GII/BGIC0282/20ll/BGD

2BBB8. 31078, 35488

209 VPI AHX22028 2D9 4BI9 9029, 13439, 17849, 22259, norovirus Hu/Gll/BGIC039I/20I2/BGD

26669, 31079, 35489

2I0 VPI AHX22032 2I0 4B20 9030, 13440. 17850, 22260, narovirus Hu/GII/BGIC00B6/2DII/BG0

26670.31080, 35490

2II VPI AHX22038 2II 4B2I 9031, 13441. 17851, 22261, narovirus Hu/Gll/BGIC0398/20I2/BGD

26671.31081, 35491

2I2 VPI AHX2204I 2I2 4B22 9032, 13442, 17852, 22262, norovirus Hu/Gll/BGIC0405/20I2/BG0

26672, 31082, 35492

2I3 VPI AHX22047 2I3 4B23 9033, 13443, 17853, 22263, norovirus Hu/GII/BGIC0004/20IO/BGD

26673, 31083, 35493

2I4 VPI AHX22050 2I4 4B24 9034, 13444, 17854, 22264, narovirus Hu/GII/BGIC024l-33/20ll/BGD

26674, 31084, 35494 I5 VPI AHX22054 215 4G25 9035. 13445, 17855, 222B5, norovirus Hu/GII/BGIC0270/20ll/BGD

2BB75, 31085, 35495

1 VPI AIA9B988 2IG 4G2B 9036, I344B, I785B, 222GB, norovirus Gil

26678, 31086, 35496

17 VPI AII025B9 217 4B27 9037, 13447, 17857, 22267, norovirus Hu/GII/l0IIB/2009/VNM

26677, 31087, 35497

18 VPI AIID2572 218 4B28 9038, 13448, 17858, 22268, norovirus Hu/GII/10054/2009/VNM

2BB78, 31088, 35498

19 VPI AII02575 219 4B29 9039, 13449, 17859, 222B9, norovirus Hu/GII/10114/2009/VNM

26679, 31089, 35499

0 VPI AII02578 220 4B30 9040, 13450, 17860, 22270, norovirus Hu/Gll/I03l3/2DI0/VNM

2BB80, 31090, 35500

2! VPI AII0258I 221 4B3I 9041, 13451, 17861, 22271, norovirus Hu/GII/30212/2009/VNM

26681, 31091, 35501

22 VPI AII02584 222 4G32 9042, 13452, 17862. 22272, norovirus Hu/GII/IOI48/2009/VNM

26682, 31092, 35502

23 VPI AII02590 223 4G33 9043, 13453, 17863, 22273, norovirus Hu/GII/IOIIO/2009/VNM

26683, 31093, 35503

24 VPI AII02593 224 4B34 9044, 13454, 17864, 22274, norovirus Hu/GII/10325/2010/VNM

2B684, 31094.35504

25 VPI AII0259B 225 4B35 9045, 13455, 17865, 22275, norovirus Hu/GII/IOIOI/2009/VNM

26685, 31095, 35505

29 VPI AII02599 22B 4B3G 9046, I345B, I78B6, 22276, norovirus Hu/GII/10002/2009/VNM

2668B, 31096, 35506

27 VPI AII02B02 227 4B37 9047, 13457, I78G7. 22277, norovirus Hu/GII/3035l/2009/VNM

2BB87, 31097, 35507

28 VPI AII02605 228 4G38 9048, 13458, 17868. 22278, norovirus Hu/GII/30448/20ID/VNM

2B688, 31098. 35508

29 VPI AII02B08 229 4B39 9049, 13459, 17869, 22279, norovirus Hu/GII/30468/20IQ/VNM

26689, 31099.35509

30 VPI AII02BI4 230 4B40 9050, 13460. 17870. 22280, norovirus Hu/GII/IOI93/2009/VNM

2BB90, 31100, 35510

31 VPI AII02G23 231 4B4I 9051, 13461, 17871, 22281, norovirus Hu/GII/20088/2009/VNM

26B91.31101. 35511 232 VPI AIID2626 232 4642 9052, 13462. 17872. 22282, norovirus Hu/Gll/20II8/200B/VNM

26692, 31102, 35512

233 VPI AIID2629 233 4G43 9053, 13463, 17873, 22283. nnrovirus Hu/GII/C2H-20/2DII/VNM

26693, 31103, 35513

234 VPI AII02632 234 4644 9054, 13464, 17874, 22284, norovirus Hu/GII/10173/2009/VNM

26694, 31104, 35514

235 VPI AIID2635 235 4645 9055, 13465, 17875, 22285, norovirus Hu/GII/IOI36/200a/VNM

26695, 31105, 35515

236 VPI AIID2638 236 4646 9056, 13466, 17876, 22286, norovirus Hu/GII/C2033/20IO/VNM

26696, 31106, 35516

237 VPI AII0264I 237 4647 9057, 13467, 17877, 22287, norovirus Hu/GII/20151/2000/VNM

26697, 31107, 35517

238 VPI AIID2644 238 4648 9058. 13468, 17878, 22288, norovirus Hu/GII/20460/2010/VNM

26698, 31108, 35518

239 VPI AIID2647 239 4649 9059, 13469, I787B, 22289, norovirus Hu/GII/10199/2009/VNM

26699, 31109, 35519

240 VPI AIID265D 24D 4G5D 9060, 13470, 17880, 22290, norovirus Hu/GII/C2007/20IO/VNM

26700, 31110, 35520

24I VPI AII02653 241 4651 9061, 13471, 17881, 22291, norovirus Hu/GII/20066/2009/VNM

26701, 3IIII, 35521

242 VPI AIID2656 242 4652 9062, 13472, 17882, 22292, norovirus Hu/GII/20479/2010/VNM

26702, 31112, 35522

243 VPI AII02659 243 4653 9063, 13473, 17883, 22293, norovirus Hu/GII/10012/2009/VNM

26703.31113, 35523

244 VPI AII02662 244 4654 9064, 13474. 17884, 22294, norovirus Hu/GII/C2H-24/20ll/VNM

26704, 31114, 35524

245 VPI AII02665 245 4655 9065, 13475, 17885, 22295, norovirus Hu/GII/10062/2009/VNM

26705, 31115, 35525

246 VPI AIID2668 246 4656 9066, 13476, 17886, 22296, norovirus Hu/GII/20494/20ID/VNM

26706, 31116, 35526

247 VPI AIID267I 247 4657 9067. 13477, 17887, 22297, norovirus Hu/GII/10079/2009/VNM

26707.3111V. 35527

248 VPI AII02674 248 4658 9068, 13478. 17888. 22298, norovirus Hu/GII/C2H-3l/20ll/VNM

26708, 31118, 35528 249 VPI AIID2677 249 4B59 9069, I3479, I7889, 22299, naravirus Hu/Gll/I0285/20IO/VNM

26709, 3III9, 35529

25D PI AIID268D 250 4660 9070, I3480, I7890, 22300, nnrovirus Hu/GII/30399/2010/VNM

267I0, 3II20, 35530

25I VPI AII02683 25I 4BBI 907I, I348I, I789I, 2230I, norovirus Hu/GII/IOI82/20D9/VNM

267II, 31121, 35531

252 VPI AIID2689 252 46B2 9072, 13482, 17892, 22302, norovirus Hu/GII/IOI58/2D09/VNM

26712, 31122, 35532

253 VPI AII02692 253 4B63 9073. 13483, 17893, 22303, naravirus Hu/GII/10176/2009/VNM

26713, 31123, 35533

254 VPI AIID2695 254 4664 9074, 13484, 17894, 22304, nnrovirus Hu/GII/2DI50/2009/VN

26714, 31124, 35534

255 VPI AII02G98 255 46B5 9075, 13485, 17895, 22305, naravirus Hu/GII/10204/2009/VNM

2B7I5, 31125, 35535

25G VPI AII027DI 256 466B 9076, 13486. 17896, 22306, naravirus Hu/GII/10034/2009/VNM

26716, 31126, 35536

257 VPI AIID27D7 257 4BB7 9077, 13487. 17897, 22307, naravirus Hu/Gll/I0075/20D9/VNM

26717, 31127, 35537

258 VPI AIID27ID 258 4BB8 9078, 13488, 17898, 22308, naravirus Hu/GII/!0074/2009/VNM

26718, 31128, 35538

259 VPI AII027I3 259 46B9 9079, 13489, 17899, 22309, naravirus Hu/GII/C2H-25/2DII/VNM

26719, 31129.35539

260 VPI AIID27I6 260 4670 9080, 13400, 17900, 22310, norovirus Hu/GII/C2H-27/20ll/VNM

26720, 31130, 35540

2BI VPI AII027I9 26I 467I 9081, 13491, 17901, 22311, naravirus Hu/GII/20486/2010/VNM

26721, 31131, 35541

262 VPI AIID2722 262 4B72 9082, 13492, 17902, 22312, naravirus Hu/GII/3DIIG/2009/VNM

26722, 31132, 35542

263 PI AIID2725 263 4B73 9083, 13493. 17003, 22313, norovirus Hu/GII/IOI08/2009/VNM

26723, 31133, 35543

264 VPI AIID2728 264 4B74 9084, 13494. 17904, 22314, norovirus Hu/GII/3024l/2009/VNM

26724, 31134, 35544

265 VPI AIID273I 265 4B75 9085, 13495, 17905, 22315, naravirus Hu/GII/30443/2010/VNM

2B725, 31135, 35545 2GB VPI AII02734 2BB 4B7B 9D8B, I349B. 17906. 223IB, norovirus Hu/GII/20092/2009/VN

26726, 31136.35546

267 PI AIID2737 2B7 4B77 9087, 13497, 17907, 22317, norovirus Hu/BII/20079/2009/VN

26727, 31137, 35547

268 VPI AIID274D 2G8 4B78 9088, 13498, 17908, 22318, naravirus Hu/GH/10137/2000/VNM

26728, 31138, 35548

2B9 VPI AIID2743 2B9 4B79 9089, 13499, 17909, 22319, naravirus Hu/GII/10051/2009/VNM

26729, 31139, 35549

27D PI AII0274B 270 4G80 9090, 13500, 17910, 22320, norovirus Hu/GII/C2H-36/20ll/VNM

26730, 31140, 35550

27I VPI AIIQ274B 27I 4G8I 9D9I, 13501, 17911, 22321. narovirus Hu/GII/20145/2009/VNM

26731, 31141, 35551

272 VPI AII02752 272 4B82 9092, 13502, 17912. 22322, norovirus Hu/GII/20188/2009/VN

26732, 31142, 35552

273 PI AIID2758 273 4G83 9093, 13503, 17913, 22323, norovirus Hu/GII/20357/2009/VNM

26733, 31143, 35553

274 VPI AIID27BI 274 4B84 9094, 13504, 17914, 22324, norovirus Hu/GII/C24l8/20ID/VNM

2B734, 31144, 35554

275 VPI AII027B4 275 4B85 9095, 13505, 17915, 22325, norovirus Hu/GII/IOI95/200B/VNM

26735, 31145, 35555

27B VPI AII027B7 27B 4B86 9096, I350B, 17916, 22326, norovirus Hu/GII/20067/2009/VNM

2673B, 31146, 3555G

277 VPI AIIQ2770 277 4B87 9097, 13507, 17917, 22327, norovirus Hu/GII/C2H-47/20ll/VN

26737, 31147, 35557

278 VPI AII02773 278 4B88 9098, 13508, 17918, 22328, norovirus Hu/GII/20107/2009/VN

26738, 31148, 35558

270 VPI AIIG277B 279 4B89 9099, 13509, 17919. 22329, norovirus Hu/GII/30473/2010/VNM

26739, 31149, 35559

280 VPI AIIB277B 280 4B90 9100, 13510, 17920, 22330. norovirus Hu/GII/10078/2009/VNM

26740, 31150.35560

28I VPI AIID2782 28I 4B9I 9101.13511, 17921,22331,26741. norovirus Hu/GII/20108/2009/VNM

31151.35561

282 VPI AII02785 282 4692 9102. 13512, 17922, 22332, norovirus Hu/GII/20154/2009/VNM

26742, 31152, 35562 283 VPI AIID2788 283 4693 9I03, I35I3. I7923, 22333, norovirus Hu/BII/3038l/20IO/VNM

26743, 31153.35563

284 VPI AII0279I 284 4694 9104, 13514, 17924, 22334, norovirus Hu/GII/C2H-48/20ll/VNM

26744, 31154, 35564

285 VPI AII02794 285 4695 9105, 13515, 17925, 22335, norovirus Hu/BII/C2035/20IO/VNM

26745, 31155, 35565

286 VPI AII02797 286 4696 9106, 13516, 17926, 22336, norovirus Hu/GII/IOI27/2009/VNM

26746, 31156, 35566

287 VPI AII028DD 287 4697 9107, 13517, 17927, 22337, norovirus Hu/GII/10194/2009/VNM

26747, 31157, 35567

288 VPI AII028D3 288 4698 9108, 13518, 17928, 22338, norovirus Hu/GII/30257/2009/VNM

26748, 31158, 35568

289 VPI AIID28D6 289 4699 9109, 13519, 17929, 22339, norovirus Hu/GII/10129/2009/VN

26749, 31159, 35569

290 VPI AII028D9 290 4700 9110, 13520, 17930, 22340, norovirus Hu/GII/C2H-50/20ll/VNM

26750, 31160, 35570

29I VPI AII028I2 29I 470I 9111, 13521, 17931, 22341,26751, norovirus Hu/GII/30303/2009/VNM

31161, 35571

292 VPI AIID28I5 292 4702 9112, 13522, 17932, 22342, norovirus Hu/GII/C2H-55/20ll/VNM

26752.31162, 35572

293 VPI AIID28I8 293 4703 9113, 13523, 17933, 22343. norovirus Hu/GII/C2365/20IO/VNM

26753, 31163, 35573

294 VPI AIIQ282I 294 4704 9114, 13524, 17934, 22344, norovirus Hu/GII/C2H-44/20ll/VNM

26754, 31164, 35574

295 VPI AIID2824 295 4705 9115, 13525, 17935, 22345, norovirus Hu/GIl/10!B9/2D09/VNM

26755, 31165, 35575

296 PI AIID2827 296 4706 9116, 13526, 17936, 22346, norovirus Hu/GII/20093/2009/VNM

26756, 31166, 35576

297 VPI AIID2830 297 4707 9117, 13527, 17937, 22347, norovirus Hu/GII/10255/2009/VN

26757, 31167, 35577

298 VPI AIID2833 298 4708 9118, 13528, 17938, 22348, norovirus Hu/GII/C2H-62/20ll/VNM

26758.31168, 35578

299 VPI AIID2836 299 4709 9119, 13529, 17939, 22349, norovirus Hu/GII/10235/2009/VNM

26759, 31169, 35579 30Q VPI AII02839 300 47I0 9I20, I3530. I7940, 22350, noravirus Hu/GII/20146/2000/VNM

2G7B0, 3II70, 35580

30I VPI AII02842 30I 47II 9I2I. 13531. 17941, 22351, norovirus Hu/GII/20123/2009/VNM

2B7BI, 31171, 35581

3D2 VPI AII02845 302 47I2 9122, 13532, 17942, 22352, norovirus Hu/GII/20370/2010/VNM

2B7B2, 31172, 35582

3D3 VPI AII02848 303 47I3 9123, 13533, 17943, 22353, norovirus Hu/GII/C2H-45/20ll/VNM

2B7B3, 31173, 35583

3D4 VP! AII0285I 304 47I4 9124, 13534, 17944, 22354, norovirus Hu/GII/IOI83/2009/VNM

2B7B4, 31174, 35584

305 VPI AII02854 305 47I5 9125, 13535, 17945, 22355, norovirus Hu/GII/20069/2009/VNM

2B7B5, 31175, 35585

30B VPI AII02857 30B 47IB 9I2B, I353B, I794B, 2235B, norovirus Hu/GII/C2H-43/2DII/VNM

267B6.31176, 3558B

307 VPI AII028B0 307 47I7 9127, 13537, 17947, 22357, norovirus Hu/GII/10145/2009/VNM

2B7B7, 31177, 35587

308 VPI AII028BB 308 47I8 9128, 13538, 17948, 22358, norovirus Hu/Gll/I0IB0/2D09/VNM

2B7B8, 31178, 35588

308 VPI AII028BB 309 47I9 9129, 13539, 17949, 22359, norovirus Hu/GII/10223/2009/VNM

2B7B9, 31179, 35589

3I0 VPI AII02872 3I0 4720 9130, 13540, 17950, 223B0, norovirus Hu/GII/10003/2009/VNM

2B770, 31180, 35590

3II VPI AII02875 3II 472I 9131, 13541, 17951, 223BI, norovirus Hu/GII/30192/2010/VNM

2B771, 31181. 35591

3I2 VPI AII02878 3I2 4722 9132, 13542, 17952, 223B2. norovirus Hu/GII/20493/2010/VNM

2B772, 31182, 35592

3I3 VPI AII0288I 3I3 4723 9133, 13543, 17953, 223B3, norovirus Hu/GII/IOI3l/2009/VNM

2B773, 31183, 35593

3I4 VPI AII02884 3I4 4724 9134, 13544, 17954, 223B4, norovirus Hu/GII/IO238/2009/VNM

2B774, 31184, 35594

3I5 VPI AII02887 3I5 4725 9135, 13545, 17955, 223B5, norovirus Hu/GII/30400/2010/VNM

2B775, 31185, 35595

3I6 PI AII02890 3IB 472B 9I3B, I354B. I795B, 223BB, norovirus Hu/GII/20153/2009/VNM

2B77B, 3II8B, 35596 3I7 VPI AII02893 3I7 4727 9I37, I3547. I7957, 223B7, norovirus Hu/GII/10037/2009/VNM

2B777. 3II87, 35597

3I8 VPI AII0289B 3I8 4728 9I3B. I3548, I7958. 223B8, norovirus Hu/GII/20144/2009/VN

2B778, 3II88, 35598

3IB VPI AII02899 3I9 4729 9139. 13549. 17959, 223B9, norovirus Hu/GII/C2H-39/20ll/VNM

2B779, 31189, 35599

320 VPI AII02902 320 4730 9I4D, 13550, 17960. 22370, norovirus Hu/GII/20122/2009/VNM

2B78B, 31190, 35G00

32I VPI AIS24557 32I 473I 9141, 13551, 17961. 22371, norovirus Gil

2B781, 31191.35B0I

322 VPI AIY30I35 322 4732 9142, 13552, I79B2, 22372, murine norovirus

2B782, 31192, 35BD2

323 VPI AKEQ7I00 323 4733 9143, 13553, I79B3, 22373, norovirus Gil

2B783, 31193.35B03

324 VPI A E07I03 324 4734 9144, 13554. I79B4. 22374, norovirus Gil

2B784, 31194, 35B04

325 VPI AKE07I0B 325 4735 9145, 13555, I79B5, 22375, norovirus Gil

2B785, 31195, 35B05

32G VPI ALQI22B0 32B 473B 9I4G, I355B, I79BB, 2237G, norovirus cat/GVI.2/TE/77-l3/ITA

2B78B, 31196.35B0G

327 VPI BAI49904 327 4737 9147. 13557. 17967, 22377, norovirus Hu/Gll.4/Hiroshima/I9/200I/JPN

26787.31197, 35607

328 VPI BAI49905 328 4738 9148. 13558, 17968, 22378, norovirus Hu/GII.4/Hiroshima/42/2004/JPN

2B788, 31198, 35608

329 VPI BAI4990B 329 4739 9149, 13559, 17969, 22379, norovirus Hu/GII.4/Hiroshima/44/2004/JPN

26789, 31199, 35609

330 VPI BAI49907 330 4740 9150, 13560, 17970, 22380, norovirus Hu/GII.4/Hiroshima/48/2004/JPN

26790, 31200.35610

331 VPI BAI499D9 33I 474I 9151. 13561, 17971, 22381. norovirus Hu/GII.4/Hiroshima/56/2005/JPN

26791, 31201, 35611

332 VP! BAI499ID 332 4742 9152, 13562, 17972, 22382, norovirus Hu/GII.4/Hiroshima/57/2005/JPN

2B792, 31202, 35BI2

333 VPI BAI499II 333 4743 9153, I35B3, 17973, 22383, norovirus Hu/GII.4/Hiroshima/58/2005/JPN

26793, 31203, 35613 334 VPI BAI499I2 334 4744 9154. I35B4, 17974, 22384, norovirus Hu/GII.4/Hiroshima/59/2005/JPN

2B734, 31204, 35BI4

335 VPI BAI499I4 335 4745 9155, I35B5, 17975, 22385, narovirus Hu/GII,4/Hiroshima/67/2006/JPN

2B795, 31205, 35BI5

336 VPI BAI499IB 33B 474B 9I5B, I35BB, I797B, 2238B, norovirus Hu/GII.4/Hiroshima/69/2006/JPN

2B79B, 3I20B, 35BIB

337 VPI BAI499I7 337 4747 9157, I35B7, 17977, 22387, norovirus Hu/GII.4/Hiroshima/74/2006/JPN

26797, 31207, 35BI7

338 VPI BAI499I8 338 4748 9158, 13568, 17378, 22388, norovirus Hu/GII.4/Hiroshima/9l/200G/JPN

26738, 3I2D8, 35618

339 VPI BAI49BI9 333 4749 9153, I35B9, 17373, 22389, norovirus Hu/GII,4/Hiroshima/92/2006/JPN

26739, 31203, 35BI3

340 VPI BAI49920 34D 4750 3160, 13570, 17380, 22390, norovirus Hu/Bll.4/Hiroshima/I08/2007/JPN

2B800, 31210, 35B20

341 VPI BAI4992I 341 4751 9161, 13571, 17981, 22391, norovirus Hu/Gll.4/Hiroshima/I09/2007/JPN

26801, 31211, 35621

342 VPI BAI49923 342 4752 9162, 13572, 17982, 22392, norovirus Hu/GII.4/Hiroshima/ll5/2007/JPN

26802, 31212, 35622

343 VPI BAI49924 343 4753 9163, 13573, 17983, 22393, norovirus Hu/Gll.4/Hiroshima/I29/2007/JPN

26803, 31213.35623

344 VPI BAI48925 344 4754 9164, 13574. 17984, 22394, norovirus Hu/Gll.4/Hiroshima/I34/2007/JPN

26804, 31214, 35624

345 VPI BAI4992B 345 4755 9165, 13575, 17985. 22395. norovirus Hu/Gll.4/Hiroshima/I39/2007/JPN

26805, 31215.35625

34B VPI BAI49927 34B 475B 9I6B, I357B, I798B, 22396, narovirus Hu/GII.4/Hirashima/l5l/2008/JPN

26806, 31216, 3562B

347 VPI BAI49B28 347 4757 9167. 13577, 17987, 22397, narovirus Hu/Gll.4/Hiroshima/I54/2008/JPN

26807.31217, 35B27

348 VPI BAJ25070 348 4758 9168, 13578, 17988, 22398, norovirus Hu/0C05024/2005/JP

26808, 31218, 35B28

349 VPI BAJ25D72 349 4759 BIBB. 13579, 17989, 22399, narovirus Hu/OCOB060/2006/JP

26803, 31213, 35629

350 VPI BAJ2507B 35D 47B0 9170, 13580, 17990, 22400, norovirus Hu/0H0701l/2007/JP

26810, 31220, 35630 35I VPI BANI6283 35I 47BI 9I7I, I358I, I799I, 2240I, narovirus Hu/GII.6/Ehirne090B46/2009/JP

268II, 3I221, 3563I

352 VPI BANI6285 352 47B2 9I72, I3582, I7992, 22402. narovirus Hu/GII.6/Ehime090056/2009/JP

268I2, 3I222.35632

353 VPI BANI6287 353 4763 9I73. I3583, I7993, 22403, narovirus Hu/GII.6/Ehime090549/2009/JP

268I3, 3I223, 35633

354 VPt BANI628B 354 47B4 9I74, I3584, 17994. 22404, norovirus Hu/GII himel20246/20l2/JP

26814, 31224.35B34

355 VPI BANI629I 355 4765 9175. 13585. 17995, 22405, narovirus Hu/GII.6/Ehim _E 050007/2005/JP

2B8I5, 31225, 35B35

356 VPI BANI6293 35B 476B 9176, I358B, 17996, 22406, narovirus Hu/GII.6/Ehima04l525/2004/JP

2B8I6.31226, 35636

357 VPI BANI6295 357 47B7 9177, 13587, 17997, 22407, norovirus Hu/GII.6/Ehime03H63/2003/JP

2B8I7, 31227, 35B37

358 VPI BANIB267 358 47B8 9178, 13588, 17998, 22408, narovirus Hu/GII.6/Ehime030769/2003/JP

26818, 31228, 35638

356 VPI BA 4228B 359 47B9 9179, 13589, 17999, 22409, narovirus

26819, 31229, 35639 Hu/GII/JP/20l5/GII.PI7_GII.I7/Kawasaki308

3BD VPI BAR47BI6 3BB 477D 9180, 13590, 18000, 22410, norovirus

26820, 31230, 35640 Hu/GII/JP/20l4/GII.PI7_GII.I7/Nagano7-l

36I VPI BAR637I5 3BI 477I 9181, 13591, 18001, 22411, norovirus

26821, 31231.35641 Hu/GII/JP/20l3/GII.PI7_GII.I7/Saitama5203

362 VPI BAR637I8 3B2 4772 9182, 13592. 18002. 22412. norovirus

26822, 31232, 35642 Hu/GII/JP/20l3/GII.PI7_GII.I7/Saitama53D9

363 VPI BAR6372I 3B3 4773 9183, 13593, 18003, 22413, norovirus

26823, 31233, 35643 Hu/GII/JP/20l4/GII.PI7_GII.I7/Nagana8-l

364 VPI BASD2D83 3B4 4774 9184, 13594, 18004, 22414, norovirus

26824, 31234, 35644 Hu/GII/JP/20l5/GII.PB_GII.4/Dsaka/0SF78

365 VPI CRL46952 3B5 4775 9185. 13595, 18005, 22415, norovirus GI/Hu/NL/2DII/GI,4/Groningen

26825, 31235, 35645

366 PI CRL46955 3BB 477B 9186, 13596, I800B, 224IB. norovirus GI/Hu/NL/2012/GI.B/Graningen

2682B.3I23B, 35B4B

367 VPI CRL46958 3B7 4777 9187, 13597, 18007, 22417, norovirus Gll/Hu/NL/20I2/Gll.4/Groningen

2B827.31237, 35647 368 VPI C L4B3BI 3B8 4778 3188, 13538, 18008, 22418, norDvirus BII/Hu/NL/20l4/GII,4/GroningBnOI

2B828, 31238, 35B48

3BB VPI CRL4B3B4 3B3 4773 3183, I353B, 18003, 22413. norovirus GII/Hu/NL/20f4/GII.4/BroningenD2

2B823, 31233, 35B43

37B VPI CRL4BBB7 370 478D 9130, I3B00, 18010, 22420, norovirus GII/Hu/NL/20!4/GII.E/Groningen

2B830, 31240, 35B50

371 VPI CRL4BB7B 371 4781 9131, 13601. 18011, 22421, norovirus Gll/Hu/NL/20I4/Gll,2l/Groningen

26831, 31241, 35B5I

372 VPI CRL4B373 372 4782 3192, I3B02, 18012, 22422, norovirus GII/Hu/NL/20l4/GII.2/GroningBn

2B832, 31242, 35B52

373 VPI CRL4G37B 373 4783 3133, I3B03, 18013, 22423, norovirus Glf/Hu/NL/2DI2/Gll.4/Nijmegen0t

2B833, 31243, 35B53

374 VPI CRL4B37B 374 4784 3134, I3B04, 18014, 22424, norovirus GII/Hu/NL/20l2/GII.4/NijmBgen02

2B834, 31244, 35B54

375 VPI ABC3B332 375 4785 BI35, I3B05, 18015, 22425, norovirus Hu/Guangzhou/NVgzOI/CHN

2B835, 31245, 35B55

37B VPI A0B27D27 37B 478B 3I3B, I3B06. 18016. 22426, norovirus HU/GII.4/NBW

2B83B, 3I24B, 35B5B DrlBansl500/2008/0SA

377 VPI AEEIBDD3 377 4787 9137, 13607. 18017, 22427. murine norovirus GV/NIH-2410/2005/OSA

26837. 31247, 35B57

378 VPI AEEIBDDB 378 4788 9198, I3B08, 18018. 22428, murine norovirus GV/NIH-24II/2005/USA

2B838, 31248, 35658

373 VPI AEEIBDB3 373 4783 9199, 13609, 18013, 22429, murine norovirus GV/NIH-2747/2O05/USA

2B839, 31249, 35659

38B VPI AEEIBDI5 38G 4730 9200, 13610. 18020, 22430, murine norovirus GV/NIH-442I/2005/0SA

26840, 31250, 35660

381 VPI AEEIBBI8 381 4731 9201, 13611, 18021. 22431, murinB norovirus GV/NIH-4428/2005/0SA

26841, 31251, 35BBI

382 VPI AEEIDB2I 382 4732 9202, 13612, 18022, 22432, murinB norovirus GV/NIH-443I/2005/0SA

26842, 31252. 35BB2

383 VPI AEEIDB24 383 4733 3203, 13613, 18023, 22433, murinB norovirus GV/NIH-AII4/2006/OSA

26843, 31253, 35BB3

384 VPI AEEIDB27 384 4734 3204, 13614, 18024, 22434, murinB norovirus GV/NIH-D22D/2007/0SA

2B844, 31254, 35664 385 VPI AGI9B385 385 4795 9205, I3BI5, 18025, 22435, norovirus Hu/GII.I/0hio/509/20IZ/USA

2B845, 31255, 35BG5

386 VPI AGI9B397 38B 479B 920B, I3BIB, I802B, 2243B. norovirus Hu/GII.G/Ohio/490/2012/USA

2B84B, 3I25B, 35BBB

387 VPI AGI9B398 387 4797 9207, I3BI7, 18027, 22437, norovirus Hu/GII.I/Ohio/507/2012/OSA

2B847, 31257, 35BB7

388 VPI AGI9B399 388 4798 9208, 13618, 18028, 22438, norovirus Hu/GII.I/Ohio/765/2012/USA

2B848, 31258.35668

389 VPI AGJ52I75 389 4799 9209, 13619, 18029, 22439. norovirus Hu/GI/HuzhouNlf/ZDDS/CHN

26849, 31259, 35BB9

3BD VPI AGX0I092 390 4800 9210, 13620, 18030, 22440. norovirus Hu/Gl.2/Jingzhou/20I340I/CHN

2B850, 31260, 35670

391 VPI AGX0I095 391 4801 9211, 13621, 18031, 22441, norovirus Hu/Gll,3/Jingzhou/20I3402/CHN

26851, 31261, 35B7I

392 VPI AGX0I098 392 4802 9212, 13622, 18032, 22442, norovirus Hu/Gll.4/Jingzhou/20I3403/CHN

26852, 31262, 35G72

393 VPI AKI300B0 393 4803 9213, 13623, 18033, 22443. norovirus Hu/GII.I7/GaithErsburg/20l4/US

26853, 31263, 35B73

394 VPI BAQ945I4 394 4804 9214, 13624, 18034, 22444, norovirus Hu/GII.I3/D8N2045/2008/NP

26854, 31264, 35674

305 VPI BAQ945IB 395 4805 9215, I3B25, 18035, 22445. norovirus Hu/GII,l3/08N2250/2008/NP

26855.3I2B5, 35675

396 VPI BAQ94520 39G 480B 9216, 13626. 18036, 2244B, norovirus Hu/GII.I3/09N3l45/20Q9/NP

2B856, 312B6, 3567B

397 VPI BAQ94524 397 4807 9217, I3B27, 18037, 22447, norovirus Hu/GII.I3/09N320B/2009/NP

26857, 31267, 35B77

398 VPI BAQ9452B 398 4808 9218, I3B28, I8D38, 22448, norovirus Hu/GII.I3/09N3223/2D09/NP

26858, 31268, 35678

399 VPI ACV89840 399 4809 9219, I3B29, I8D39, 22449, norovirus dog/GVI.I/HKU_Ca026F/2007/H G

2B859, 31269, 35B79

400 VPI ACV89843 400 4810 9220, I3B30, I8D40, 22450, norovirus dog/GVI.I/HK0_Ca035F/2007/HKG

2B860, 31270, 35680

401 VPI AFV4804B 401 4811 9221, 13631. 18041. 22451, norovirus n/GV/HK0_CT2/HKG/20ll

26861, 31271, 35B8I 402 VPI AFV48048 402 4812 9222, I3B32, I8B42, 22452, narovirus Rn/GV/HKUJCT/HKG/2012

2G8B2, 31272, 35B82

403 VP! AGH06682 403 4813 9223, I3B33, 18043, 22453, norovirus rat/GI/KSI2/l3Q5/DNK

2B863, 31273, 35B83

404 VPI AGL984I3 404 4814 9224, I3B34, 18044, 22454, norovirus Hu/GII.4/CI27/GF/1978

2B8B4, 31274, 35B84

405 PI AGL984I4 405 4815 9225, 13635, 18045, 22455, norovirus Hu/Gll/KL45/MY/I978

26865, 31275, 35B85

406 VPI AGL984I6 40B 48IB 922B, I3B3B, I804B, 2245B, norovirus Hu/Gll/T09l/TN/I976

2B8BB, 3I27B, 35B86

407 VPI BAL60749 407 4817 9227, 13637, 18047, 22457, norovirus Hu/GII,2/DC05ll4/2005/JP

26867.31277, 35B87

408 VPI BAL60753 4D8 4818 9228, 13638, 18048, 22458. norovirus Hu/GII,2/0C05l45/2005/JP

26868, 31278, 35688

409 VPI BALB0755 409 4819 9229, I3B39, 18049, 22459, norovirus Hu/GII,2/OC06005/200B/JP

26869, 31279, 35689

410 VPI BALB0759 4ID 4820 9230, 13640, 18050, 22460, norovirus Hu/GII.2/0C060l4/20DB/JP

2B870, 31280, 35B90

411 VPI BALB07B7 411 4821 9231, 13641, 18051, 22461, norovirus Hu/GII,2/0C08l24/2008/JP

26871, 31281, 35691

412 VPI BALB07B9 412 4822 9232, 13642, 18052, 22462, norovirus Hu/GII,2/DCD8l54/2008/JP

2B872, 31282, 35B92

413 VPI BALB077I 413 4823 9233, I3B43, 18053, 224B3, norovirus Hu/GII.2/0C09044/2009/JP

26873, 31283, 35693

414 VPI BALB0773 414 4824 9234, 13644, 18054, 22464, norovirus Hu/GII.2/0H0G023/2006/JP

26874, 31284, 35694

415 VPI BALB0775 415 4825 9235, 13645, I8D55, 22465, norovirus Hu/GII.2/OHD700l/2007/JP

2B875, 31285, 35B95

416 VPI BAL60777 4IB 482B 9236, 13646, I805B, 224B6, norovirus Hu/GII.2/OH070l3/2007/JP

26876, 31286, 3569B

417 PI BALG0779 417 4827 9237, I3B47, 18057, 224B7, norovirus Hu/GII.2/0H08009/20D8/JP

2B877, 31287, 35B97

418 VPI BALB078I 418 4828 9238, I3B48. 18058, 22468, norovirus Hu/GII.2/0HD80l9/2008/JP

26878, 31288, 35698 419 VPI BALB0783 419 4829 3233, 13649, 18059, 224B9, nDrDvirus Hu/GII.2/OH08020/2008/JP

2B879, 31289, 35093

420 VPI BALB0785 420 4830 924B, I3G50, I80B0, 22470, norovirus Hu/GII.2/DH08029-2/20D8/JP

26880, 31230, 35700

421 VPI BALB079I 421 4831 3241, 13651, 18061, 22471, norovirus Hu/GII.2/0C09l03/2009/JP

26881, 31231, 35701

422 VPI BALB0793 422 4832 9242, 13652, 18062, 22472, norovirus Hu/BII.2/0C09l04/2009/JP

26882, 3I2B2, 35702

423 VPI BALB0795 423 4833 3243, I3B53, 18063, 22473. norovirus Hu/GII.2/0CD9ID9-2/2D03/JP

26883, 31233.35703

424 VPI BALB0797 424 4834 9244, 13654, 18064, 22474, norovirus HU/GII.2/0CI0009/20ID/JP

26884, 31234, 35704

425 VPI BALB073B 425 4835 3245, I3B55, I80G5, 22475, norovirus Hu/GII.2/OCIOOI2-2/20IO/JP

26885, 31235, 35705

42B VPI BALB080I 42B 483B 924B. I3B56. 18066, 22476, nnrovirus Hu/GII.2/OCIOOI8-2/20IO/JP

26886.31296, 35706

427 VPI BALB0803 427 4837 3247, 13657. 18067. 22477, norovirus Hu/GII.2/OCIOOI9/20IO/JP

26887, 31297, 35707

428 VPI BALB0805 428 4838 3248, 13658, 18068, 22478, norovirus Hu/GII.2/OCI002G/20IO/JP

26888, 31298, 35708

423 VPI BALB0809 42B 4833 3243, I3B53, 18063, 22473, norovirus Hu/GII.2/0H09028/2DD9/JP

26883, 31233, 35703

430 VPI BALB08II 430 4840 3250, I36B0, 18070, 22480, norovirus Hu/GII.2/0H09029/2009/JP

26890, 31300, 35710

431 VPI BALB08I3 431 4841 9251, 13661, 18071, 22481, norovirus Hu/GII,2/OH09030/2009/JP

26891, 31301.35711

432 VPI BALB08I5 432 4842 9252, 13662, 18072, 22482, norovirus Hu/GII.2/DH03032/20D9/JP

26892, 31302, 35712

433 VPI BALB08I7 433 4843 9253, 13663, 18073. 22483. norovirus Hu/GII.2/0H03034/2OO3/JP

26893, 31303, 35713

434 VPI BALB08I9 434 4844 9254, 13664, 18074, 22484, norovirus Hu/GII.2/0H09035/2009/JP

26894, 31304, 35714

435 VPI BAL6082I 435 4845 9255, 13665, 18075, 22485, norovirus Hu/GII.2/DHIOODI/20IO/JP

26895, 31305, 35715 436 PI BAL6D823 43G 484B 9256, I3BBB. 18076. 2248B, naravirus Hu/GII.2/0HI0005-2/20l0/JP

2B896, 3I30B, 35716

437 VPI BAL6D825 437 4847 9257, I36B7, 18077, 22487, norovirus Hu/GII.2/0HI00O6/20IO/JP

2B897, 31307, 35717

438 PI BAL60827 438 4848 9258, I36G8, 18078, 22488, norovirus Hu/GII.2/0HI0007/20IO/JP

26898, 31308, 35718

43B VPI BALBD823 439 484B 9259, I3BBB, 18079, 22480, nor _D virus Hu/GII.2/QHI0008/20IO/JP

26898, 31309, 35719

440 VPI BALB083I 44D 4850 92B0, 13670, 18080, 22490, norovirus Hu/GII.2/OHIO0ll-2/2DIO/JP

26900, 31310, 35720

441 VPI BALB0833 441 4851 92BI, 13671, 18081, 22491. norovirus Hu/GII.2/OHIOOI2/20IO/JP

2B901, 31311, 35721

442 VPI BALBD835 442 4852 9262, 13672, 18082, 22492, norovirus Hu/GII.2/OHIOOI3/20IO/JP

26902, 31312.35722

443 VPI BALBD837 443 4853 9263, 13673. 18083. 22493, norovirus Hu/GII.2/OHIOOI5-2/20IO/JP

26903, 31313, 35723

444 VPI BAL60839 444 4854 9264, I3B74, 18084, 22494, norovirus Hu/GII.2/0HI0020/20ID/JP

26904, 31314, 35724

445 VPI BAL6084I 445 4855 92B5, 13675, 18085, 22495. norovirus Hu/GII.2/OHI002l/20IO/JP

2B905, 31315, 35725

446 VPI BALBD843 446 485B 926B, 13676, 18086, 22496, norovirus Hu/GII.2/DHID024/20IO/JP

26906, 31316, 3572B

447 VPI BALBD845 447 4857 9267, 13677, 18087. 22497, norovirus Hu/GII.2/OHI0025/20IO/JP

26907, 31317, 35727

448 VPI BALBD847 448 4858 92B8, 13678, 18088, 22498, norovirus Hu/GII.2/0HI002B/2OIO/JP

26908, 31318, 35728

44B VPI BAL6084B 443 4859 9269, 13679, 18089, 22499, norovirus Hu/GII.2/DHI0029/20IO/JP

26909, 31319, 35729

45D VPI BAL6D85I 450 4860 9270. 13680, 18090, 22500, norovirus Hu/GII.2/OHI003l/20IO/JP

26910, 31320.35730

451 VPI AATD0378 451 4861 9271, 13681, 18091, 22501, norovirus Sydney 2212

26911, 31321, 35731

452 VPI ABD95934 452 4862 9272, 13682, 18092, 22502, norovirus Gil

26912, 31322, 35732 453 VPI A6G495D9 453 48B3 9273, I3B83, I8D93, 22503, norovirus Hu/GII.4/MD-2004/2004/US

2B9I3, 31323.35733

454 VPI ABP88833 454 48B4 9274, 13684, I8D94, 22504, norovirus Hu/Guangzhou/NV-VPI/2006/China

26914, 31324, 35734

455 VPI ABY2756D 455 4865 9275. 13685, 18095, 22505, norovirus Hu/Houston/TCHI8B/2002/0S

26915, 31325, 35735

456 VPI ACT76I39 456 486B 9276, I3B8B, 18096, 22506. norovirus Hu/GII.4/CH0C5l9l/l974/US

2B9IB, 31326, 3573B

457 VPI ACT7BI42 457 4867 9277, 13687, 18097, 22507, norovirus Hu/GII.4/CHDC2094/l974/US

26917.31327, 35737

458 VPI ACT76I45 458 4868 9278, 13688, 18098, 22508, norovirus Hu/Gll.4/CHDC39B7/I988/0S

26918, 31328, 35738

45B VPI ACT76I48 450 48B9 9279, 13689, 18099. 225D9. norovirus Hu/GII.4/CHOC4IOB/l987/US

26919, 3I32B, 35739

480 VPI ACT76I5I 46D 487D 9280, 13690, 18100, 22510, norovirus Hu/GII.4/CHDC487l/l977/US

26920, 31330, 35740

461 VPI ACX3I82I 461 4871 9281. 13691. 18101. 22511, norovirus Hu/GII.4/ ivieral53D/Z0D8/US

26921, 31331, 3574!

462 VPI ACX3I837 462 4872 9282, 13692, 18102, 22512, norovirus Hu/GII.4/NSW5l5L/2007/AU

26922, 31332.35742

463 VPI ACX3I84I 4B3 4873 9283, 13693, 18103. 22513, norovirus Hu/GII.4/VIC3863/20D7/AU

26923, 31333, 35743

464 VPI ACX3I85I 4B4 4874 9284, 13694, 18104, 22514, norovirus Hu/GII.4/NSW6l8P/2008/AU

26924, 31334, 35744

465 VPI ACX3I856 4B5 4875 9285, I3B95, 18105, 22515, norovirus Hu/GII.4/NSW536S/ZDD8/AU

2B925, 31335.35745

466 VPI ACX3I8BD 46B 487B 928B. 13696. 18106, 22516. norovirus Hu/GII.4/NSW587V/ZDD7/AU

2692B.31336, 35746

467 PI ACX3I8B4 4B7 4877 9287, 13697, 18107, 22517, norovirus Hu/GII.4/NSW8D6J/ZDD8/AU

26927, 31337, 35747

468 VPI ACX3I889 468 4878 9288. I3G98, 18108, 22518, norovirus

2B928, 31338, 35748 Hu/GII.4/0range/NSWOOIP/20O8/AU

469 VPI ACX3I893 4B9 487B 9289, 13699. 18109, 22518. norovirus Hu/Gll.g- 26929, 31339, 35749 GII.I2/StGBorge/NSWI99U/2D08/AU 47D VPI ACXG9259 470 4880 9290, 13700, 18110. 22520, nQrovirus dog/GVI.I/Bari/91/2007/ITA

26930, 31340, 35750

471 VPI ADF47I3I 471 4881 9291. 13701, IBM. 22521, norovirus Hu/Shanghai/SH3I2/2D09/CHN

2G931, 31341, 35751

472 VPI A0 788G9 472 4882 9292, I37D2, 18112, 22522, norovirus Hu/GII.4/Hong

26932, 31342, 35752 Kong/CUQG0027/200G/CHN

473 VPI ADR78872 473 4883 9293, 13703, 18113. 22523, norovirus Hu/GII.4/Hong

26933, 31343, 35753 Kong/CU0600l2/2006/CHN

474 VPI A0R78875 474 4884 9294, 13704, 18114, 22524, norovirus Hu/GII.4/Hong

26834, 31344, 35754 Kong/CU0G0036/2006/CHN

475 VPI ADR78878 475 4885 9295, 13705, 18115, 22525, norovirus Hu/GII.4/Hong

26935, 31345, 35755 Kong/C00600D9/2006/CHN

47G VPI ADR7888I 476 4886 9296, 13706, 18116, 2252G, norovirus Hu/GII.4/Hong

26936, 31346, 35756 K _D ng/C0060028/2006/CHN

477 PI ADR78884 477 4887 9297, 13707, 1811V. 22527, norovirus Hu/GII.4/Hong

2B937. 31347, 35757 Kong/C0060026/2006/CHN

478 VPI ADR78887 478 4888 9298, 13708, 18118. 22528, norovirus Hu/GII.4/Hong

2G938, 31348, 35758 Kong/C0060D30/2006/CHN

479 VPI ADR7889Q 479 4880 9233, 13709, 18119, 22529, norovirus Hu/GII.4/Hong

2B339. 31349, 35759 Kong/C0060037/2006/CHN

48D VPI ADR78893 480 4890 9300, 13710, 18120, 22530, norovirus Hu/GII.4/Hong

2B940, 31350, 357B0 Kong/C006003l/2006/CHN

481 VPI ADR7889G 481 4891 9301, 13711, 18121, 22531, norovirus Hu/GII.4/Hong

26941, 31351, 35761 Kang/CU06000l/200G/CHN

482 VPI ADR78809 482 4802 9302, 13712, 18122, 22532, norovirus Hu/GII.4/Hong

26942, 31352, 35762 ong/C0060039/2006/CHN

483 VPI A0R789D2 483 4893 9303, 13713, 18123, 22533, norovirus Hu/GII,4/Hnng

2G943, 31353, 35763 Kong/CU0600l4/2D06/CHN

484 PI ADR78905 484 4894 93D4, 13714, 18124, 22534, norovirus Hu/GII.4/Hong

26044, 31354, 35764 Kong/C0060024/2006/CHN

485 VPI ADR789Q8 485 4895 9305, 13715, 18125, 22535, norovirus Hu/GII.4/Hong

26945, 31355, 35765 Kong/C0060025/200G/CHN

48G VPI ADR789II 486 4896 93D6, 13716, 18126, 22536, norovirus Hu/GII.4/Hong

26946, 31356, 3576B Kong/CU050l4l/2005/CHN 487 VPI AD 789I4 487 4897 9307, 13717, 18127, 22537, norovirus Hu/GII.4/Hong

2B947, 31357, 357B7 Kong/C004l2l3/2004/CHN

488 VPI ADR789I7 488 4898 9308, 13718, 18128, 22538, norovirus Hu/GII.4/Hong

2B948, 31358, 357B8 Kong/CU05Di40/2DD5/CHN

480 VPI ADR78920 489 4899 9309, 13719, 18129, 22539, norovirus Hu/GII.4/Hong

2B949, 31359, 357B9 ong/C0050IOB/2005/CHN

490 VPI ADR78923 490 4900 9310, 13720, 18130, 22540, norovirus Hu/GII.4/Hong

2B950, 3I3BD, 35770 Kong/GU05II4G/2005/CHN

491 VPI ADR78929 491 4901 9311, 13721, 18131, 22541, norovirus Hu/GII.4/Hung

2B951, 31361. 35771 Kong/C004l206/2004/CHN

492 VPI ADR78932 492 4902 9312, 13722, 18132, 22542, norovirus Hu/GII.4/Hong

26952, 3I3B2, 35772 Kong/C004l225/2004/CHN

493 VPI ADR78938 493 49D3 9313, 13723, 18133, 22543, norovirus Hu/GII.4/Hong

2B953, 31363, 35773 Kong/CU050l36/2005/CHN

494 VPI ADR7894I 494 4904 9314, 13724, 18134, 22544, norovirus Hu/GII.4/Hong

26954, 31364, 35774 Kong/C0050l52/2005/CHN

495 VPI A0R78944 495 4905 9315, 13725, 18135, 22545, norovirus Hu/GII.4/Hong

26955, 31365, 35775 Kong/C004l222/2004/CHN

49B VPI ADR78947 496 49DB 9316, 13726, 18136, 22546, norovirus Hu/GII.4/Hang

26956, 31366, 35776 Kong/C005D852/2005/CHN

497 VPI ADR78950 497 4907 9317, 13727, 18137, 22547, norovirus Hu/GII.4/Hong

26957. 31367, 35777 Kong/C005IOI3/2005/CHN

498 VPI ADR7895B 498 4908 9318, 13728. 18138. 22548. norovirus Hu/GII.4/Hong

26958, 31368.35778 Kong/CU050l30/2005/CHN

499 VPI AEA02I24 499 4909 9319, 13729, 18139, 22540, norovirus Hu/GI/Vancouver730/2004/CAN

26959, 31369, 35779

5DD VPI AED02033 5D0 4910 9320, 13730, 18140. 22550. norovirus Hu/Gll.3/CHDC5365/I99l/0S

26960. 31370. 35780

501 VPI AED02034 501 4911 9321, 13731, 18141, 22551, norovirus Hu/GII.3/CHDC52GI/l900/OS

26961. 31371.35781

502 VPI AEDD2035 502 4912 9322, 13732, 18142, 22552, norovirus Hu/Gll.3/CHDC467I/I979/0S

26962, 31372, 35782

503 VPI AE0D2037 503 4913 9323. 13733, 18143, 22553, norovirus Hu/GII.3/CHDC403l/l988/US

26963, 31373, 35783 504 VPI AED02038 504 4914 9324. 13734, 18144, 22554, norovirus Hu/Gll.3/CHDC2DD5/IE75/US

2B9G4, 31374, 35784

505 VPI AED0203B 5D5 4915 9325, 13735, 18145, 22555, norovirus Hu/GII.3/CHDC32/l97B/US

2B9B5, 31375, 35785

50B VPI AEG7B290 SOB 49IB 932B, I373B. 18146. 2255B. norovirus Hu/GII.4/Hong

2B9BB, 3I37B, 3578B Kong/COBDOI/2010/CHN

507 VPI AEI2958B 507 4917 9327. 13737, 18147, 22557, norovirus Hu/BII.I2/HS20B/20ID/USA

2B9B7, 31377, 35787

508 VPI AEJ82B4B 508 4918 9328. 13738, 18148, 22558, nornvirus

2B9B8, 31378, 35788 Hu/GII.4/Houston/TCH492/2005/0S

500 VPI AERII308 509 4919 9329, 13739, 18149, 22559, norovirus Hu/GII.4/04R-2/2004/TW

2B9B9, 31379, 35789

5I0 VPI AE II3I0 510 4920 9330, 13740, 18150, 225B0, norovirus Hu/GII.4/05R-2/2005/TW

2B970, 31380, 35790

5II VPI AERII3I2 511 4921 9331, 13741, 18151. 225BI. norovirus Hu/GII.4/06-A -2/200B/TW

2B971.31381, 35791

5I2 VPI AERII3I4 512 4922 9332, 13742, 18152, 225B2, norovirus Hu/GII,4/0G-CK-2/2006/TW

2B972, 31382, 35792

513 VPI AERII3IB 513 4923 9333, 13743, 18153, 225B3, norovirus Hu/GII.4/06-T-2/2006/TW

26973, 31383, 35793

514 PI AERII3I8 514 4924 9334, 13744, 18154, 22564, norovirus Hu/GII.4/0B-BQ-G/200B/TW

26974, 31384, 35794

515 VPI AER1I320 515 4925 9335, 13745. 18155, 225B5, norovirus Hu/GII.4/0B-CJ-l/2006/TW

2B975, 31385, 35795

SIB VPI AERII324 5IB 492B 9336, 13746, 18156, 22566, norovirus Hu/GII.4/06-CI-l/200B/TW

2697B, 31386, 35796

517 VPI AERII32B 517 4927 9337, 13747, 18157, 22567, norovirus Hu/GII.4/07-B-l/200G/TW

2B977, 31387, 35797

518 VPI AERII328 518 4928 9338. 13748. 18158. 22568, norovirus Hu/GII.4/07-AG-l/20D6/TW

26978. 31388, 35798

5IB VPI AERII330 519 4929 9339, 13749, 18159, 22569, norovirus Hu/GII.4/07-H-3/2006/TW

26979, 31389, 35799

520 VPI AERII332 520 4930 9340, 13750, 18160, 22570, norovirus Hu/GII.4/08-E/2006/TW

26980, 31390, 35800 I VPI AE II334 52I 493I 934I, I375I, I8I6I, 2257I, narovirus Hu/GII.4/08-P-l(2006b)/2008/TW

26981, 3I391, 358DI

2 VPI AERII336 522 4932 9342, I3752, 18I62, 22572, naravirus Hu/GII.4/08-D-l(2008a)/2008/TW

26982, 3I392, 358D2

3 VPI AERII34D 523 4933 9343, I3753, I8I63, 22573, naravirus Hu/GII.4/08-H-l(2D08a)/2008/TW

26983, 3I393, 35803

4 VPI AERII342 524 4934 9344, I3754, I8I64, 22574, naravirus Hu/GII.4/08- -l(2008a)/2008/TW

26984, 3I394. 358D4

5 VPI AERII344 525 4935 9345, I3755, I8I65, 22575, naravirus Hu/GII.4/08-N-l(2D08a)/2008/TW

26985, 3I395, 358D5

6 VPI AERII346 526 4936 9346, I3756, I8I66, 22576, norovirus Hu/GII.4/08-0-2(2008a)/2008/TW

26986, 3I396, 35806

7 VPI AERII348 527 4937 9347, I3757, I8I67, 22577, noravirus Hu/GII.4/08-U-2(2D08a)/2008/TW

26987, 3I307, 35807

8 VPI AERII35D 528 4938 0348, I3758, I8I68, 22578, norovirus Hu/GII.4/08-W-l(2008b)/2008/TW

26088, 3I308, 35808

B VPI AERII352 520 4939 9348. I3759, I8I60, 22570, norovirus Hu/GII.4/08-AA(2008b)/2008/TW

26080, 3I390, 35808

D VPI AERII354 53D 494D 0350. I3760, 18170. 22580. narovirus Hu/GII.4/09-L-4(2009a)/2000/TW

26000. 31400. 35810

! PI AERH356 53I 494I 0351, 13761, 18171. 22581. naravirus HU/GII.4/OG-N-I(2000B)/200G/TW

26901, 31401. 35811

2 VPI AERII358 532 4942 0352, 13762, 18172, 22582, norovirus Hu/GH.4/IO-A-l(20D9b)/20IO/TW

26092, 31402. 35812

3 VPI AERII36D 533 4943 9353. 13763, 18173, 22583, naravirus Hu/GII.4/00-BI-2- 26093, 31403, 35813 l(2000b)/2D09/TW

4 VPI AEXI0549 534 4944 0354, 13764, 18174, 22584, narovirus Hu/GII.3/MilwaukBB009/20ID/USA

26904, 31404, 35814

5 VPI AEXBieiO 535 4945 0355, 13765. 18175, 22585. narovirus Hu/GII.4/New Orleans/2010/USA

26005, 31405, 35815

6 VPI AFD3D97D 536 4946 9356, 13766, 18176, 22586, norovirus cat/GIV.2/C008l2IOE/USA/20IO

26896, 31406, 35816

7 VPI AFH88383 537 4947 0357. 13767. 18177, 22587, norovirus

26907, 31407, 35817 Hu/GI.G/ ingston/ACTIGOD/ZDIO/AU 538 VPI AFJ2I37G 538 4948 9358, I37B8, I8I78, 22588, norovirus

2B338, 3I4B8, 358I8 Hu/GIV.I/LakeMacquarie/NS 2680/20IO/AU

539 VPI AFJ2I379 539 4943 3353, I37B3, I8I7B. 22589, norovirus Hu/Gll.g- 26999, 3I409, 358I9 GII.I2/Gunnedah/NSW895P/20IO/AU

540 VPI AFJ2I382 540 4350 93B0, I3770, I8I80, 22590, norovirus Hu/Gll.g- 27000, 3I4I0, 35820 GII.I2/Wahraonga/NSW004P/2009/AU

54I VPI AFJ2I387 54I 495I 93BI, 13771, 18181. 22591, norovirus Hu/GII.4/HSW375L/2OO7/A0

27B01, 31411, 35821

542 VPI AFJ2I388 542 4952 33B2, 13772. 18182, 22592, norovirus Hu/GII.4/NSW72ll/2007/AU

27002, 31412, 35822

543 VPI AFJ2I389 543 4953 S3E3, 13773, 18183, 22533, norovirus Hu/GII,4/WAI45H/2007/AU

27003, 31413, 35823

544 VPI AFJ2I390 544 4954 93B4, 13774, 18184. 22594. norovirus Hu/GII.4/NSW833M/2007/A0

27004, 31414, 35824

545 VPI AFJ2I39I 545 4955 93B5, 13775, 18185, 22595, norovirus Hu/GII.4/WA223N/2007/AU

27D05.31415, 35825

54B VPI AFJ2I392 54B 495B 93BB. I377B, 18186, 2259B, norovirus Hu/GII.4/WAI45Y/2007/AU

27D0B, 31416. 35826

547 VPI AFJ2I393 547 4957 93B7, 13777, 18187, 22597, norovirus Hu/GII.4/NSW050D/2007/AU

27007, 31417. 35827

548 VPI AFJ2I394 548 4958 93B8, 13778, 18188, 22598, norovirus Hu/GII.4/NSWII5M/2007/AU

27008, 31418, 35828

549 VPI AFJ2I395 549 4959 33B9, 13779, 18189, 22599, norovirus Hu/GII.4/NSW358W/2007/AU

27009, 31419, 35829

550 VPI AFJ2I39B 550 49B0 9370. 13780, 18190, 22B00, norovirus Hu/GII.4/NSW3B0P/2OO7/A0

27010.31420, 35830

55I VPI AFJ2I397 55I 4SBI 3371, 13781, 18191, 22B0I. norovirus Hu/GII.4/WA2IOZ/2007/AU

27011, 31421, 35831

552 VPI AFJ2I398 552 43B2 9372. 13782, 18192, 22B02, norovirus Hu/GII.4/NSWI800/2008/AO

27012, 31422, 35832

553 VPI AFJ2I3B3 553 43B3 9373, 13783, 18193, 22B03, norovirus Hu/GII.4/NSW39l2/20O8/AU

27013, 31423, 35833

554 VPI AFJ2I4B0 554 43B4 9374, 13784, 18194, 22604, norovirus Hu/GII,4/NSW04IG/2008/A0

27014, 31424. 35834 555 VPI AFJ2I4QI 555 49G5 9375, I3785, 18195. 226D5, norovirus Hu/GII,4/NSW3IIO/2008/AO

27015, 31425, 35835

556 PI AFJ2I4Q2 556 4966 9376, 13786, 18196, 22606, norovirus Hu/GII.4/NSW764Q/2008/AU

27016, 31426, 35836

557 VPI AFJ2I403 557 4967 9377, 13787, 18197, 22607, norovirus Hu/GII.4/NSW863B/2008/AU

27017. 31427, 35837

558 VPI AFJ2I404 558 4968 9378, 13788, 18198, 22608, norovirus Hu/GII.4/NSW8B8H/2OO8/A0

27018, 31428, 35838

559 PI AFJ2I4D5 559 4969 9379, 13789, 18199, 22609, norovirus Hu/BII.4/NSW8l9D/2DD9/AU

27019. 31429, 35839

5GD VPI AFJ2I4D6 56D 4970 9380, 13790, 18200, 226ID, norovirus Hu/GII.4/NSW89IU/2009/AU

27020. 31430, 3584D

SGI VPI AFJ2I4D7 5GI 4B71 9381, 13791, 18201, 22611, norovirus Hu/GII.4/NSW82IJ/200B/A0

27021, 31431, 35841

562 VPI AFJ2I4Q9 562 4972 9382, 13792, 18202, 22612, norovirus Hu/GII.4/NSW963U/2009/A0

27022, 31432, 35842

563 VPI AFJ2I4IQ 563 4973 0383, 13793, 18203, 22613, norovirus Hu/GII.4/NSW957X/2009/A0

27023, 31433, 35843

564 VPI AFJ2I4II 564 4974 9384, 13794, 18204, 22614, norovirus Hu/GII.4/NSW972V/2009/AU

27024, 31434, 35844

5G5 VPI AFJ2I4I3 565 4975 9385, 13795, 18205, 22615, norovirus Hu/GII.4/NSW4240/20D9/A0

27025, 31435, 35845

566 VPI AFJ2I4I4 56G 4976 9386, 13796, 18206. 22616. norovirus Hu/GII.4/NSWB74U/2D0B/AU

27026, 31436, 35846

567 VPI AFJ2I4I5 567 4977 0387, 13797, 18207. 22617, norovirus Hu/GII.4/NSW5l4M/2009/AU

27027. 31437, 35847

568 VPI AFJ2I4I6 568 4978 9388, 13798, 18208, 22618, norovirus Hu/GII.4/NSW88B4/2009/A0

27028, 31438. 35848

560 VPI AFJ2I4I7 569 4979 9389, 13799, 18209, 22619, norovirus Hu/GII.4/NSW399Z/20D9/AU

27029, 31439, 35849

57G VPI AFJ2I4I8 570 4B8D 9390, 13800, 18210, 22620, norovirus Hu/GII.4/NSW452P/2009/A0

27030. 3I44D, 35850

57! VPI AFJ2I4I0 57! 498I 9391, 13801, 18211, 22621, norovirus Hu/GII.4/NSW447T/2009/AU

27031.31441, 35851 572 VPI AFJ2I42D 572 4382 9392. 13802. 18212, 22B22, norovirus Hu/GII.4/NSW58IT/2009/AO

27032, 31442, 35852

573 VPI AFJ2I42I 573 4B83 9393. 13803, 18213, 22B23. norovirus Hu/GII.4/NSWI3IL/2009/AU

27033, 31443, 35853

574 VPI AFJ2I422 574 4984 9394, 13804, 18214, 22B24, norovirus Hu/GII.4/NSW006P/2009/AU

27034, 31444, 35854

575 VPI AFJ2I423 575 4385 9395, 13805, 18215, 22B25, norovirus Hu/GII.4/NSWOI59/20ID/AU

27035, 31445, 35855

57G VPI AFJ2I424 57B 438B 9336, I380B, 18216, 22B2B, norovirus Hu/BII.4/NSW827P/2DID/AU

2703B, 31446, 35856

577 VPI AFJ2I425 577 4987 9397, 13807, 18217, 22B27, norovirus Hu/GII.4/NSW673P/20IO/AU

27037, 31447, 35857

578 VPI AFJ2I42B 578 4388 9398, 13808, 18218, 22628, norovirus Hu/GII.4/NSWD75J/2DI0/AU

27038.31448.35858

57B VPI AFJ2I428 579 4383 9399, 13809, 18219, 22629, norovirus Hu/GII.4/NSW0396/20IO/AU

27039, 31449, 35859

580 VPI AFJ2I429 580 4330 9400, 13810. 18220, 22630, norovirus Hu/GII.4/NSWI443/2DID/AU

27040, 31450, 35860

581 VPI AFJ2I43D 581 4331 9401, 13811, 18221, 22631. norovirus Hu/GII.4/NSW3D44/2DID/AU

27041, 31451, 35861

582 VPI AFJ2I43I 582 4932 9402. 13812, 18222, 22632. norovirus Hu/Gll.4/NSWG73H/20I0/A0

27042.31452, 35862

583 PI AFJ2I432 583 4993 9403, 13813. 18223. 22B33, norovirus Hu/GII.4/NSWI23B/20IO/AU

27043, 31453, 35863

584 VPI AFJ2I433 584 4994 9404. 13814, 18224, 22634, norovirus Hu/GII.4/NSWI86M/2DI0/A0

27044, 31454, 358B4

585 VPI AFJ2I434 585 4995 9405, 13815, 18225, 22B35, norovirus Hu/GII.4/NSW2l8E/20IO/AU

27045, 31455.35865

58B VPI AFJ2I43B 58B 4996 9406, 13816, 18226. 22636, norovirus Hu/GII.4/NSWD75G/2DI0/AU

2704B, 31456, 358BB

587 VPI AFJ2I437 587 4997 9407, 13817, 18227. 22637. norovirus Hu/Gll.4/NSW688R/20I0/A0

27D47, 31457, 35867

588 VPI AFJ2I438 588 4998 9408, 13818, 18228, 22638, norovirus Hu/GII.4/NSW68ll/20IO/AU

27048.31458, 35868 589 VPI AFJ2I433 589 4393 3403, I38I9, I8223, 22B33, norovirus Hu/GII.4/NSW2004/20IO/AU

27049, 3I453, 358B9

590 VPI AFJ2I440 590 5000 34I0, I3820, I8230, 22B40, narovirus Hu/GII.4/NSW445E/20IO/AU

27050, 3I4B0, 35870

59I VPI AFJ2I44I 59I 500I 34II, 13821. 18231, 22B4I, narovirus Hu/BII.4/NSW2340/20IO/AU

27051, 31461, 35871

592 VPI AFJ2I442 532 5002 9412, 13822, 18232, 22642, norovirus Hu/GII.4/NSW827D/ZDID/AU

27052, 31462, 35872

593 VPI AFJ2I443 533 5003 9413, 13823, 18233, 22B43, noravirus Hu/GII.4/NSWB039/2QI0/AU

27053, 3I4B3, 35873

594 VPI AFJ2I444 534 5004 3414, 13824, 18234, 22644, norovirus Hu/GII.4/NSW944J/20ID/AU

27D54, 31464, 35874

595 VPI AFJ2I445 595 5005 3415, 13825, 18235, 22B45, norovirus Hu/GII.4/NSW057J/20IO/AU

27055, 3I4B5, 35875

59B VPI AFJ2I44B 59B 5D0B 34IB, I382B, 18236, 22B4B, norovirus Hu/GII.4/NSW5G7H/2DI0/AU

27056, 3I46B, 35876

597 VPI AFJ2I448 537 5007 3417, 13827, 18237, 22B47, norovirus

27057, 3I4B7, 35877 Hu/GII.4/Miranda/NSWBI7L/2DI0/AU

538 VPI AFJ2I45I 538 5008 3418, 13828, 18238, 22648, norovirus

27058, 3I4B8, 35878 Hu/GII.4/StVincents/NSW2l7l/2DI0/AU

539 VPI AFJ2I454 533 5009 9419, 13829, 18239, 22649, norovirus

27059, 31469, 35879 Hu/GII.4/Helensburgh/NSW295E/20IO/AU

BOO VPI AFL70023 BOB 50I0 9420, 13830, 18240, 22650, norovirus Hu/GII.4/5M/USA/2004

27D60, 31470, 35880

BDI VPI AFN0B724 BOI 50II 9421, 13831, 18241, 22651, norovirus Hu/GII.B/S9c/SN/I976

27061, 31471, 35881

BD2 VPI AFN0B725 B02 50I2 9422, 13832, 18242, 22652, norovirus Hu/Gll.6/S7e/SN/I976

27062, 31472, 35882

B03 VPI AFN06726 B03 50I3 0423, 13833, 18243, 22653, norovirus Hu/Gll.2/KLI09/MY/I978

27063, 31473, 35883

B04 VPI AFN0B727 B04 50I4 9424, 13834, 18244, 22654, norovirus Hu/GIU4/HK74/CN/l978

27064, 31474, 35884

BOS VPI AFN0B728 B05 50I5 9425, 13835, 18245, 22655, norovirus Hu/Gll.3/HK7I/CN/I978

27065, 31475, 35885 BDB VPI AFNDB729 BDB 5DIB 942B, I383G, I824B, 22B5B, norovirus Hu/Gll.3/HK54/CN/I977

270BB, 3I47B. 3588B

BD7 VPI AFN06730 B07 50I7 9427, I3837, I8247, 22B57, norovirus Hu/GII.G/HK28/CN/I977

270B7. 3I477. 35887

BDB VPI AFNDB73I BDB 5DI8 9428, I3838, I8248, 22B58, norovirus Hu/Gll.7/HK4/CN/I976

270B8, 3I478, 35888

BDB VPI AFNDB732 BD9 5DI9 9429, I3839, I8249, 22B59, norovirus Hu/GII.I7/CI42/GF/l978

27DBB, 3I479, 35889

BID VPI AFNDB733 BID 5D2D 9430, I3840, I825D. 22BB0, norovirus Hu/GII.5/CI5/GF/l978

27070, 31480, 3589D

Bll PI AFN06734 Bll 5D2I 943I, I384I, I825I, 22BBI, norovirus Hu/GI.G/HKBD/CN/1977

27071, 3I4813589I

BI2 VPI AFNDB735 BI2 5022 9432, I3842, I8252, 22BB2, norovirus Hu/Bl.5/E57/UG/I975

27D72, 3I482, 35892

6I3 VPI AFN06736 BI3 5023 9433, I3843, I8253, 22663. norovirus Hu/Gl/E8/UG/I97G

27D73, 3I483, 35893

BI4 VPI AFN0B738 BI4 5D24 9434, I3844, I8254, 22664, norovirus Hu/Gl.3/C9/GF/I978

27D74, 31484, 35894

BI5 VPI AFN0B739 BIS 5025 9435, 13845, 18255, 226B5, norovirus Hu/Gl.3/B8/CF/I977

27D75, 31485, 35895

BIB VPI AFVD877I BIB 5D2B 9436. 13846, 18256, 22BB6, norovirus

27076, 31486, 35896 Hu/GII.4/Randwick/NSW882J/20ll/A0

BI7 VPI AFVD8774 BI7 5D27 9437, 13847, 18257, 226B7, norovirus

27077, 31487, 35897 Hu/GII.4/Caringbah/NSW4D3G/ZDII/AU

BI8 VPI AFV08777 BI8 5D28 9438, 13848, 18258, 22BB8, norovirus

27078, 31488, 35898 Hu/GII.4/Berowra/NSW767L/20l2/AU

BIB VPI AFVD878D BI9 5D29 943B, 13849, 18259, 22B69, norovirus

27079, 3I48B, 35899 Hu/GII.4/Jannali/NSW774M/2DII/AU

B2D VPI AFVD8783 B2D 5030 9440, I385D, I82B0, 22670, norovirus

27080, 31490, 3590D Hu/GII.4/Doonsid_/NSW536l/20ll/AU

B2I VPI AFVD878B B2I 503I 9441, 13851, 18261, 22671, norovirus

27081, 31491, 35901 Hu/GII.4/Randwick/NSW938K/2DII/AU

B22 VPI AFV08789 B22 5032 9442, 13852, 18262, 22G72, norovirus

27082, 31492, 35902 Hu/GII.4/Miranda/NSW85BK/ZBII/AU 623 VPI AFV087B2 623 5033 9443, I3853, I82B3, 22B73, norovirus

27083, 31493.35903 Hu/GII,4/WoDnona/NSW330B/20l2/A0

G24 VPI AFVB8795 624 5034 9444, 13854, 18264, 22B74, norovirus

27084, 31494, 35904 Hu/GII.4/Sydney/NSW05l4/20l2/A0

B25 VPI AFX9594D 625 5035 9445, 13855, I82B5, 22B75, norovirus Hu/GII.4/Hong

27085, 31495, 35905 ong/COHK3630/20I2/CHN

B2B VPI AFZ84663 B26 503B 9446, 13856, 18266, 22B76, norovirus Hu/GII.4/HSI9l/2004/USA

27086, 31496, 35906

B27 PI AGG3787I B27 5037 9447, 13857. 18267, 22677, norovirus Hu/Gll.4/Taichung/I2-BA- 27087, 31497, 35907 I/20I2/TW

628 PI AGI9B383 628 5038 9448, 13858, 18268, 22B78, norovirus Hu/GII.4/0hio/684/USA

27088, 31498, 35908

629 VPI AGI99552 629 5039 9449, 13859, 18269, 22679, norovirus

27089, 31499, 35909 Hu/GII.4/VPII72/Shanghai/20l2/CHN

B3D VPI AGIB9553 630 5040 9450, I38B0, 18270, 22680, norovirus

27090, 31500, 35910 Hu/GII.4/VPI2l4/Shanghai/20l2/CHN

63I VPI AGIS9554 63I 504I 9451, 13861, 18271. 22B81, norovirus

27091, 31501.3591! Hu/GII.4/VP!28l/Shanghai/20l2/CHN

632 VPI AGI99555 G32 5042 9452, 13862. 18272, 22682, norovirus

27092, 31502, 35912 Hu/GII.4/VPI45l/Shanghai/20l2/CHN

B33 VPI AG 25882 B33 5043 9453, 13863, 18273, 22683, norovirus Hu/GII-4/New

27093, 31503, 35913 Taipei/CGMH49/20ll/TW

634 VPI AGK25884 B34 5044 9454, I38B4, 18274. 22684. norovirus Hu/GII-4/New

27094, 31504, 35914 Taipei/CGMH50/20ll/TW

635 PI AGK25887 635 5045 9455, I38B5, 18275, 22685, norovirus Hu/GII- 27095, 31505, 35915 4/Taoyuan/CGMH5l/20l2/TW

63B VPI AGK25890 636 504B 9456, 13866, 18276, 22686, norovirus Hu/GII- 27096, 31506, 35916 4/Taoyuao/CGMH52/20l2/TW

B37 PI AG 25892 637 5047 9457, I38G7, 18277, 22B87, norovirus Hu/GII-4/New

27097, 31507, 35917 Tai _P Bi/CGMH53/20l2/TW

B38 VPI AGK25898 B38 5048 9458, 13868, 18278, 22688, norovirus Hu/GII- 27098, 31508, 35918 4/Taoyuan/CGMH55/20l2/TW

63B VPI AGK2590D B39 5049 9459, 13869, 18279, 22B89, norovirus Hu/GII-4/New

27099. 31509, 35919 Taipei/CGMH56/20l2/TW B40 VPI AGK25BD2 B4D 5050 9460, I3870, I8280, 22B90. norovirus Hu/GII- 27I00, 31510. 35920 4/Ta _D yuan/CGMH57/20l2/TW

B4I VPI AGK25905 B4I 505I 9461, 13871, 18281, 22691, norovirus HU/GII-4/HEW

27101, 31511, 35921 Taipei/CG H58/20l2/TW

B42 VPI AG 25908 B42 5D52 9462, 13872, 18282, 22692, norovirus Hu/GII- 27102, 31512, 35022 4/TaDyuan/CGMH59/20l2/TW

643 VPI AGK259I0 B43 5053 9463, 13873, 18283, 22B93, norovirus Hu/GII- 27103, 31513, 35923 4/Taoyuan/CGMH60/20l2/TW

B44 VPI AGK259I2 B44 5D54 9464, 13874, 18284, 22694, nnrovirus Hu/GII-4/New

27104, 31514, 35924 Taipei/CG HGI/20l2/TW

B45 VPI AGK259I5 B45 5D55 94B5, 13875, 18285, 22B95, norovirus Hu/GII-4/New

27105, 31515, 35925 Tai _P Bi/CGMH62/20l2/TW

B4B VPI AGK259I7 B4B 5D5B 946B, 13876, I828B, 22B9B, norovirus Hu/GII- 27106, 31516, 35926 4/Taoyuan/CGMH63/20l2/TW

B47 VPI AGK259I9 B47 5057 94B7, 13877. 18287, 22697. norovirus Hu/GII- 27107, 31517. 35927 4/Taoyuan/CGMH64/20l2/TW

B48 VPI AGK2592I B48 5058 9468, 13878, 18288, 22698, norovirus Hu/GII- 27108, 31518, 35928 4/Taoyuan/CGMHB5/20l2/TW

B49 VPI AGK25924 B49 5059 9469. 13879, 18289, 22699, norovirus Hu/GII- 27109, 31519, 35929 4/Taoyuan/GGMH66/20l2/TW

B5D VPI AGK25927 B5D 50B0 9470, 13880, 18290, 22700, norovirus Hu/GII- 27110, 31520, 35930 4/Taoyuan/CG H67/20l2/TW

B5I VPI AGK2593Q B5I 50BI 9471, 13881, 18291, 22701, 27111, norovirus Hu/GII-4/New

31521, 35931 Tai _P Bi/CGMHB8/20l2/TW

B52 VPI AGS08025 B52 50B2 9472, 13882, 18292. 22702, norovirus Hu/Gll.4/ACT0675/20I2/A0

27112, 31522, 35932

653 VPI AGSD8D2B 653 50B3 9473, 13883, 18293, 22703, norovirus Hu/GII.4/NSW0025/2DII/AU

27113. 31523, 35933

B54 VPI AGSD8D27 B54 50B4 9474, 13884, 18294, 22704, norovirus Hu/GII.4/NSW00BB/2DI2/A0

27114, 31524, 35934

B55 VPI AGSD8D28 655 50B5 9475, 13885, 18295, 22705, norovirus Hu/GII.4/NSW007P/20l2/AU

27115, 31525, 35935

B5B VPI AGS08Q29 B5B 50BB 947B, 13886, 18296, 22706, norovirus Hu/GII.4/NSW0287/20l2/A0

27116, 3I52B, 3593B 657 VPI AGS08D3D G57 5DB7 9477, I3887, I8297. 22707, noravirus Hu/GII.4/NSW035H/20l2/AU

27II7. 3I527, 35937

658 VPI AGSD8D3I G58 5DB8 9478, I3888, I8298, 22708, noravirus Hu/GII.4/NSW052l/20l2/AU

27II8, 3I528, 35938

B59 VPI AGSD8032 659 5GB9 9479, 13889, 18299. 22709, noravirus Hu/GII,4/NSWD7B J/2011/AU

27119, 31529, 35939

BBO VPI AGS08033 GGD 5D7D 9480, 13890, 18300, 22710, noravirus Hu/GII,4/NSW078G/20l2/AU

27120, 31530, 35940

BBI VPI AGS08035 BBI 5G7I 9481, 13891, 18301, 22711, noravirus Hu/GII.4/NSW097K/20l2/AU

27121, 31531, 35941

BB2 VPI AGSD8Q36 BB2 5D72 9482, 13892, 18302, 22712, noravirus Hu/GII,4/NSW0988/20l2/AU

27122, 31532, 35942

BB3 VPI AGSD8D37 BB3 5073 9483. 13893, 18303, 22713, noravirus Hu/GII.4/NSWI0BI/20l2/AU

27123, 31533, 35943

BB4 VPI AGS08038 BB4 5074 9484, 13894, 18304, 22714, noravirus Hu/GII.4/NSWII4H/2DI2/AU

27124, 31534, 35944

BB5 VPI AGSD8040 6B5 5075 9485. 13895, 18305, 22715, noravirus Hu/GII.4/NSWI50E/20ll/AU

27125, 31535. 35945

BBG VPI AGSQ8Q4I BBG 507B 948B, 13896. I830B, 227IB, noravirus Hu/GII.4/NSWI523/20l2/AU

27126. 3I53G, 3594B

BB7 VPI AGSD8Q42 BB7 5077 9487. I38B7. 18307, 22717, noravirus Hu/GII.4/NSWI5BD/2DII/AU

27127, 31537, 35947

BB8 VPI AGSQ8Q43 BB8 5078 9488. 13898. 18308. 22718, noravirus Hu/GII.4/NSWIG27/2DI2/AU

27128, 31538.35948

BB9 VPI AGSD8044 BB9 507B 9489, 13899, 18309, 22719, noravirus Hu/GII.4/NSWI652/20l2/AU

27129, 31539, 35949

B70 VPI AGSD8Q45 B7D 5080 9490, 13900, 18310, 22720, noravirus Hu/GII.4/HSWI749/20ll/AU

27I3D, 31540, 35950

B7I VPI AGSD8D47 B7I 508I 9491, 13901, 18311, 22721, 27131. noravirus Hu/GII.4/NSW2D24/2DI2/AU

31541, 35951

B72 VPI AGS08048 B72 5082 9492, 13902, 18312, 22722, noravirus Hu/GII.4/NSW209B/20l2/AU

27132, 31542, 35952

B73 VPI AGSD8Q50 B73 5083 9493, 13903, 18313, 22723, noravirus Hu/GII.4/NSW230B/2012/AU

27133, 31543, 35953 674 VPI AGSD8G5I 674 5084 9494, 13904, 18314, 22724, norovirus Hu/GII.4/NSW23l7/2DII/AU

27134, 31544, 35954

G75 PI AGS08052 675 5085 9495, 13905. 18315, 22725, norovirus Hu/GII.4/NSW25BB/2DI2/AU

27135, 31545, 35955

G7G VPI AGS08G54 676 5086 9496, 13906, 18316, 22726, norovirus Hu/GII.4/NSW27DF/2DI2/AU

27I3G, 31546, 35956

G77 VPI AGS08D5G G77 5087 9497, 13907, 18317, 22727. norovirus Hu/GII.4/NSW2949/20l2/AU

27137, 31547, 35957

G78 VPI AGSD8D57 678 5088 9498, 13908, 18318, 22728, norovirus Hu/GII.4/NSW295G/20l2/AU

27138.31548, 35958

G7B VPI AGS08058 679 5089 9499, 13909, 18319. 22729, norovirus Hu/GII.4/NSW3IDB/2DI2/AU

27139, 31549, 35959

680 VPI AGSQ8G59 680 5090 95D0, 13910, 18320, 22730, norovirus

27140, 31550, 35960 Hu/GIL4/Sutherlano7NSW3IIA/20l2/A0

G8I VPI AGSD8D6Q 681 5091 9501,13911, 18321,22731,27141, norovirus

31551, 35961 Hu/GII.4/Randwick/NSW3IIA/20l2/AU

G82 VPI AGSD8D6I G82 5092 9502, 13912, 18322, 22732, norovirus Hu/GII.4/NSW3l3C/20ll/A0

27142, 31552, 35962

683 VPI AGSD8DG2 G83 5093 9503, 13913, 18323, 22733, norovirus Hu/GII.4/NSW3l92/20l2/AU

27143, 31553, 35963

G84 VPI AGS08063 684 5094 9504, 13914, 18324, 22734, norovirus Hu/GII.4/NSW323l/20l2/AU

27144, 31554, 35964

G85 VPI AGSD8064 685 5095 9505, 13915, 18325, 22735, norovirus Hu/GII.4/NSW33BH/20ll/AU

27145, 31555, 35965

G8G VPI AGSQ80G5 686 5096 9506, 13916, 18326, 22736, norovirus Hu/GII.4/NSW3440/20l2/AU

27146, 31556.35966

G87 VPI AGSD8066 687 5097 9507, 13917, 18327, 22737, norovirus Hu/GII.4/NSW348l/20l2/AU

27147, 31557, 35967

G88 VPI AGS08067 688 5098 9508, 13918, 18328, 22738, norovirus Hu/GII.4/NSW349B/20l2/AU

27148, 31558, 35968

689 VPI AGSD8D68 689 5099 9509, 13919, 18329, 22739, norovirus Hu/GII.4/NSW3522/20l2/AU

27149, 31559, 35969

69Q PI AGSD8D69 690 5100 9510, 13920, 18330, 22740. norovirus Hu/GII.4/NSW3B4K/2DII/AU

27150, 31560, 35970 B9I VPI AGS08070 G9I 5I0I 9511, 13921, 18331, 22741, 27151, norovirus Hu/GII.4/NSW3G9N/ZDIZ/AU

31561, 35971

B9Z VPI AGS0807I 692 5I02 9512, 13922, 18332, 22742, norovirus Hu/GII.4/NSW389W/20l2/A0

27152, 31562, 35972

693 VPI AGS08072 B93 5I03 9513, 13923, 18333, 22743, norovirus Hu/GII.4/NSW39ll/20ll/AU

27153, 31563, 35973

604 VPI AGS08073 694 5I04 9514, 13924, 18334, 22744, norovirus Hu/GII.4/NSW392G/20ll/A0

27154, 31564, 35974

B95 PI AGS08074 695 5I05 9515, 13925, 18335, 22745, norovirus Hu/GII.4/NSW4ll8/20l2/AU

27155, 31565, 35975

B9B VPI AGS08076 B9B 5ID6 9516, 13926, 18336, 22746, norovirus Hu/GII.4/NSW426H/2DII/AU

27156, 3I5B6, 35976

B97 VPI AGS08079 B97 5I07 9517, 13927, 18337, 22747, norovirus Hu/GII.4/NSW4379/20ll/AU

27157, 3I5B7, 35977

B98 VPI AGS08080 698 5I08 9518, 13928, 18338, 22748, norovirus Hu/GII.4/NSW4483/20l2/AU

27158, 3I5B8, 35978

699 VPI AGS0808I 699 5I09 9519, 13929, 18339, 22749, norovirus Hu/GII.4/NSW45l2/20l2/AU

27159, 31569, 35979

7DQ VPI AGS08082 70D 5II0 9520, 13930, 18340, 22750, norovirus Hu/Gll.4/NSW457G/20I2/A0

27160, 31570, 35980

7DI VPI AGS08083 70I 5III 9521, 13931, 18341, 22751, norovirus Hu/GII.4/NSW465J/2DII/AU

27161, 31571, 35981

7D2 VPI AGS08084 702 5II2 9522, 13932, 18342, 22752, norovirus Hu/GII.4/NSW468J/20ll/AU

27162, 31572, 35982

703 VPI AGS08085 703 5113 9523, 13933, 18343, 22753, norovirus Hu/GII.4/NSW489T/ZDI2/AU

27163, 31573, 35983

7D4 VPI AGS08086 704 5114 9524, 13934, 18344, 22754, norovirus Hu/GII.4/NSW5000/2QI2/AU

27IB4, 31574, 35984

705 VPI AGS08087 705 5115 9525, 13935, 18345, 22755, norovirus Hu/GII.4/NSW5047/20ll/AU

27IB5, 31575, 35985

7D6 VPI AGS08088 706 5116 9526. 13936, 18346, 22756, norovirus Hu/GII.4/NSW5l2D/ZDI2/AU

27IB6, 31576, 35986

707 VPI AGS08089 707 5117 9527, 13937, 18347, 22757, norovirus Hu/GII.4/NSW52G3/2DII/AU

27167, 31577, 35987 708 VPI AGS08090 708 5118 9528. 13938, 18348, 22758, narovirus Hu/GII.4/NSW550F/2DI2/A0

27IG8, 31578, 35988

709 VPI AGS0809I 709 5119 9529, 13939, 18349, 22759, narovirus Hu/GII.4/NSW5S8V/2DI2/AU

27IB9, 31579, 35989

710 VPI AGS08092 710 5120 9530, 13940, 18350, 227B0, narovirus Hu/GII.4/NSW5599/20lf/AU

27170, 31580, 35990

711 VPI AGS08093 711 5121 9531, 13941, 18351, 227BI, narovirus Hu/GII.4/NSW563F/20l2/AU

27171, 31581, 35991

712 VPI AGS08094 712 5122 9532, 13942, 18352, 227G2, noravirus Hu/GII.4/NSW57IK/ZDII/AU

27172, 31582, 35992

713 VPI AGS08095 713 5123 9533, 13943, 18353, 227B3, narovirus Hu/GII.4/NSW574H/20l2/AU

27173, 31583, 35993

714 VPI AGS0809G 714 5124 9534, 13944, 18354, 227B4, narovirus Hu/Gll.4/NSW57BT/20I2/A0

27174, 31584, 35994

715 VPI AGS08097 715 5125 9535, 13945, 18355, 227G5, narovirus Hu/GII.4/NSW580G/20ll/AO

27175, 31585, 35995

7IB VPI AGS08098 7IB 5I2B 953B, I394B, I835B, 227GB, noravirus Hu/GII.4/NSW584J/20ll/A0

27I7G, 3I58B.3599G

717 PI AGS08099 717 5127 9537, 13947, 18357, 227B7, narovirus Hu/GII.4/NSW58G8/20l2/AU

27177, 31587, 35997

718 VPI AGS08I00 718 5128 9538, 13948, 18358, 227B8, noravirus Hu/GII,4/HSW590J/20l2/AU

27178, 31588, 35998

719 VPI AGS08I0I 719 5120 9539, 13949, 18359, 227B9, noravirus Hu/GII.4/NSW59GM/20II/A0

27179, 31589, 35999

720 VPI AGS08I02 720 5130 9540, 13950, I83B0, 22770, noravirus Hu/GII.4/NSW5BB0/20l2/AU

27180, 31590, 3B000

721 VPI AGS08I03 721 5131 9541, 13951, 18361. 22771, noravirus Hu/Gll.4/NSWG027/20I2/A0

27181, 31591, 3B001

722 VPI AGS08I04 722 5132 9542, 13952, I83B2, 22772, narovirus Hu/GII.4/NSWBI42/20ll/AU

27182, 31592, 3B002

723 VPI AGS08I05 723 5133 9543, 13953, I83B3, 22773, noravirus Hu/GII.4/NSWBI5H/20l2/AU

27183, 31593, 3B003

724 VPI AGS08I0G 724 5134 9544, 13954, I83B4, 22774, noravirus Hu/GII.4/NSWBI68/20l2/AU

27184, 31594, 3B004 725 PI AGSD8IQ7 725 5135 9545, 13955, I83G5, 22775, norovirus Hu/GII.4/NSW6l9D/20l2/AU

27185, 31595, 3GD05

72G VPt AGSD8ID8 72G 5I3G 954G, 13956. I83BG, 22776, norovirus Hu/GII.4/NSWG23B/20ll/AU

27186, 3I59B, 360G6

727 VPI AGSG8I09 727 5137 9547, 13957, 18367, 22777, norovirus Hu/GII.4/NSW628G/20l2/AU

27187, 31597, 36GG7

728 VPI AGSD8IID 728 5138 9548, 13958, 18368, 22778, norovirus Hu/GII.4/NSWBZBT/2012/AU

27188, 31598, 36008

729 VPI AGSD8III 729 5139 9549, 13959, 18369, 22779. norovirus Hu/Gll.4/NSWB3BQ/20I2/A0

27189, 31599, 36009

73D VPI AGS08II2 73D 5I4G 9550, I39B0, 18370, 22780, norovirus Hu/GII.4/NSW65IH/20ll/AU

27190, 31600, 36010

731 VPI AGSD8II3 731 5141 9551, 13961, 18371, 22781, norovirus Hu/GII.4/NSW660C/20ll/AU

27131. 31601, 36011

732 VPI AGS08II4 732 5142 9552, 13962, 18372. 22782, norovirus Hu/GII.4/NSW6698/20l2/A0

27192, 31602, 3B0I2

733 VPI AGSD8II5 733 5143 9553, 13963, 18373, 22783, norovirus Hu/GII.4/NSWG75N/2DI2/AU

27193, 31603, 3B0I3

734 VPI AGSD8IIG 734 5144 9554, 13964. 18374, 22784, norovirus Hu/GII.4/NSW67GP/20l2/AU

27194. 3IB04, 3B0I4

735 VPI AGSG8II7 735 5145 9555, 13965, 18375, 22785, norovirus Hu/GII.4/NSWB79Q/20l!/AU

27195, 31605, 3B0I5

73B VPI AGSD8II9 736 5I4G 9556, 13966, 18376. 22786, norovirus Hu/GII.4/NSW6982/20l2/A0

27I9B, 31606, 36016

737 VPI AGS08I20 737 5147 9557, I39B7, 18377, 22787, norovirus Hu/GII.4/NSW707P/20ll/AU

27197, 31607, 36017

738 VPI AGSD8I2I 738 5148 9558, I3BB8, 18378, 22788, norovirus Hu/GII.4/NSW7l07/20l2/AU

27198, 31608, 36018

739 VPI AGSD8I22 739 5149 9559, 13969, 18379, 22789, norovirus Hu/GII.4/NSW7ll7/20l2/AU

27199, 31609, 36019

74D VPI AGS08I24 74D 5I5D 9560, 13970, 18380, 22790. norovirus Hu/GII.4/NSW7l88/20l2/AU

2720D, 31610. 36020

741 VPI AGSD8I25 741 5151 9561, 13971, 18381, 22791, norovirus Hu/GII.4/NSW74GS/2DI2/AU

27201, 31611. 36021 742 VPI AGSD8I2B 742 5152 35B2, 13372, 18382, 22732, norovirus Hu/GII.4/NSW748N/20l2/AU

27202, 3IBI2, 3BD22

743 VPI AGSD8I27 743 5153 35B3, 13973. 18383, 22733, norovirus Hu/GII.4/NSW767N/20ll/AU

272D3, 31613.36023

744 VPI AGSD8I28 744 5154 3564, 13374, 18384, 22734, norovirus Hu/GII.4/NSW783l/20ll/AU

27204, 31614.3B024

745 VPI AGSD8I2B 745 5155 35B5, 13375, 18385, 22735, norovirus Hu/GII.4/NSW783R/20ll/AU

27205.31615.36D25

74B PI AGS08I30 74G 5156 3566. 13376, I838B, 2273B, norovirus Hu/Gll,4/NSW797K/20I2/A0

27206, 31616, 36026

747 VPI AGS08I3I 747 5157 9567, 13377, 18387, 22797, norovirus Hu/GII.4/NSW8IIC/20l2/AU

27207, 31617, 3B027

748 VPI AGSD8I32 748 5158 3568, 13378, 18388, 22738, norovirus Hu/GII.4/NSW8IIG/20ll/AU

27208, 31618, 36028

74B VPI AGS08I33 74B 5153 3563, 13373, 18389, 22793, norovirus Hu/GII.4/NSW820J/20ll/AU

27209, 31619.36029

75D VPI AGSD8I34 75D 5160 9570, 13980, 18390, 22800. norovirus Hu/GII.4/NSW824F/20l2/AU

27210, 31620, 36030

751 VPI AGSD8I35 751 5IBI 3571, 13981, 18391, 22801, norovirus Hu/GII.4/NSW82GF/20ll/AU

27211, 31621, 36031

752 VPI AGSD8I3G 752 5IB2 9572, 13982, 18392, 22802, norovirus Hu/GII.4/NSW8347/20l2/AU

27212, 31622, 36032

753 VPI AGS08I37 753 5IB3 9573, 13983, 18393, 22803, norovirus Hu/GII.4/NSW83BI/2DI2/AU

27213, 31623, 3B033

754 VPI AGSB8I38 754 5IB4 9574, 13984, 18394, 22804, norovirus Hu/GII.4/NSW840H/20l2/AU

27214, 3IB24, 36034

755 VPI AGSG8I33 755 5IB5 9575, 13985, 18395, 22805, norovirus Hu/GII.4/NSW8482/2DI2/AU

27215, 31625, 36035

75B VPI AGSG8I4D 75B 5IBB 9576, 13986, I839B, 2280B, norovirus Hu/GII.4/NSW8G2G/20l2/AU

27216, 31626, 36036

757 VPI AGS08I4I 757 5167 3577, 13387. 18337. 22807, norovirus Hu/GII.4/NSW8G32/2DI2/AU

27217, 3IB27, 3B037

758 VPI AGSB8I42 758 5IB8 3578, 13988. 18398, 22808, norovirus Hu/GII.4/NSW868l/20l2/AU

27218, 3IB28, 3B038 759 VPI AGS08I43 759 5169 9579, 13989, 18399, 22809, norovirus Hu/GII.4/NSW893l/20ll/AU

27210, 31629, 36039

7BD VPI AGS08I44 760 5170 9580, 13990, 18400, 22810, norovirus Hu/GII.4/NSW906P/2DI2/A0

27220, 31630, 36040

761 VPI AGS08I45 761 5171 9581, 13991, 18401, 22811, norovirus Hu/GII.4/NSW9l6G/20l2/AU

27221, 31631, 36041

762 VPI AGS08I46 762 5172 9582, 13902, 18402, 22812, norovirus Hu/GII.4/NSW9l7l/20l2/AU

27222, 31632, 36042

763 VPI AGS08I47 763 5173 9583, 13993, 18403, 22813, norovirus Hu/GII.4/NSW9334/20l2/A0

27223, 31633, 36043

764 VPI AGS08I48 764 5174 9584, 13994, I84D4, 22814, norovirus Hu/GII.4/NSW9393/20l2/AU

27224, 31634, 36044

765 VPI AGS0BI49 765 5175 9585, 13995, 18405, 22815, norovirus Hu/GII,4/NSW959S/20l2/A0

27225, 31635, 36045

766 VPI AGS08I50 766 5176 9586, 13996, 18406, 22816, norovirus Hu/GII.4/NSW982P/20ll/A0

27226, 31636, 36046

767 VPI AGS08I52 767 5177 9587, 13997, 18407, 22817, norovirus Hu/GII.4/NLV-IO-6l4/20IO/NZ

27227, 31637, 36047

768 VPI AGS08I53 768 5178 9588, 13998, I84D8, 2Z8I8, norovirus Hu/GII.4/NLV-IO-640/20IO/NZ

27228, 31638, 36048

769 VPI AGS08I54 769 5179 9589, 13999, 18409, 22819, norovirus Hu/GII.4/NLV-l2-l034/20IZ/NZ

27229, 31639, 36049

770 VPI AGS08I57 77D 5180 9590, 14000, 18410. 22820. norovirus Hu/GII.4/NLV-l2-l072/20l2/NZ

27230, 31640, 36050

771 VPI AGS08I58 771 5181 9591, 14001, 18411, 22821, norovirus Hu/GII.4/NLV-l2-308/2OI2/NZ

27231, 31641, 36051

772 VPI AGS08I60 772 5182 9592, 14002. 18412, 22822. norovirus Hu/GII.4/NLV-l2-50l/20l2/NZ

27232, 31642, 36052

773 VPI AGS08I6I 773 5183 9593, 14003, 18413, 22823, norovirus Hu/GII.4/NLV-l2-5l4/2DI2/NZ

27233, 31643, 36053

774 VPI AGS08I62 774 5184 9594. 14004, 18414, 22824, norovirus Hu/GII,4/NLV-l2-548/20l2/NZ

27234.31644, 36054

775 VPI AGS08I63 775 5185 9595, 14005, 18415, 22825, norovirus Hu/GII.4/NLV-l2-583/20l2/NZ

27235, 31645, 36055 776 VPI AGS08I64 776 5186 9596, 14006, 18416, 22826, nnrnvirus Hu/GII.4/NLV-IZ-BD7/2DI2/NZ

27236, 31646, 36056

777 VPI AGS08I65 777 5187 9597, 14007, 18417, 22827, nornvirus Hu/GII.4/NLV-IZ-GI5 20l2/NZ

27237, 31647, 36057

778 VPI AGS08I66 778 5188 9598. 14008, 18418, 22828, nornvirus Hu/GH.4/NLV-12-BZB 2DI2/NZ

27238, 31648, 36058

779 VPI AGS08I67 779 5189 9599, 14009, 18419, 22829, norovirus Hu/GII.4/NLV-IZ-B5/Z0IZ/NZ

27239, 31649, 36059

780 VPI AGS08IG8 780 5190 9600, 14010, 18420, 22830, nornvirus Hu/GII.4/NLV-IZ-G7l/Z0IZ/NZ

27240, 31650, 36060

781 VPI AGS08IG9 781 5191 9601, 14011, 18421, 22831, norovirus Hu/BII.4/NLV-IZ-B72/ZDI2/NZ

27241, 31651, 36061

782 VPI AGS08I70 782 5192 9602, 14012, 18422, 22832, norovirus Hu/GII.4/NLV-IZ-7l3/ZDI2/NZ

27242, 31652, 36062

783 VPI AGS08I7I 783 5193 9603, 14013, 18423, 22833, norovirus Hu/GII.4/NLV-l2-7Z3/ZDIZ/NZ

27243, 31653, 36063

784 VPI AGS08I72 784 5194 9604, 14014, 18424, 22834, norovirus Hu/GII.4/NLV-IZ-73/2DIZ/NZ

27244, 31654, 36064

785 VPI AGS08I73 785 5195 9605, 14015, 18425, 22835, norovirus Hu/GII.4/NLV-IZ-734/2DI2/NZ

27245. 31655, 36065

786 VPI AGS08I74 786 5196 96D6, I4DI6, 18426, 22836. norovirus Hu/GII.4/NLV-IZ-758/Z01Z/NZ

27246. 31656, 36066

787 VPI AGS08I75 787 5197 9607, 14017. 18427, 22837, norovirus Hu/GII.4/NLV-IZ-7B3/Z0IZ/NZ

27247, 31657, 36067

788 VPI AGS08I7G 788 5198 9608, 14018, 18428. 22838, norovirus Hu/GII.4/NLV-IZ-787 ZDIZ/NZ

27248, 31658, 36068

789 VPI AGS08I77 789 5I9B 9609, 14019, 18429, 22839, norovirus Hu/GII.4/NLV-IZ-8D3/Z0IZ/NZ

27249. 31650, 36069

790 VPI AGS08I78 790 5200 0610, 14020, 18430, 22840, norovirus Hu/GII.4/NLV-IZ-809/ZOIZ/NZ

27250, 31660, 36070

791 VPI AGS08I79 791 5201 9611, 14021, 18431. 22841. norovirus Hu/GII.4/HLV-IZ-83l/ZDIZ/NZ

27251, 31661, 36071

792 VPI AGS08I80 792 5202 9612, 14022, 18432, 22842, norovirus Hu/GII.4/NLV-IZ-90Z/ZOIZ/NZ

27252.31662, 36072 703 VPI AGS08I8I 793 5203 9GI3. I4D23. 18433, 22843, norovirus Hu/GII,4/NLV-l2-932/20l2/NZ

27253, 3IGG3, 3G073

794 VPI AGS08I82 794 5204 9GI4, 14024, 18434, 22844, norovirus HU/GII.4/NLV-I2-934/20I2/NZ

27254, 31664, 36074

705 VPI AGT39I8I 795 5205 9615, 14025, 18435, 22845, norovirus Hu/GII.3/CGMH36/20IO/TW

27255, 31665, 36075

796 VPI AGT39I9I 79G 520B 9616, 14026, 18436, 22846, norovirus Hu/GII.I2/CGMH38/20ID/TW

27256, 31666. 36076

797 VPI AGT39I94 797 5207 9617, 14027, 18437, 22847, norovirus Hu/GII.I2/CGMH39/20IO/TW

27257, 31667, 36077

798 VPI AGT39I97 798 5208 9618, 14028, 18438, 22848, norovirus Hu/GII.I2/CGMH4D/20IO/TW

27258, 31668. 36078

799 VPI AGT39200 799 5209 9619, 14029, 18439, 22849, norovirus Hu/GII.I2/CGMH4l/20IO/TW

27259, 31669, 36079

800 VPI AGT39203 800 5210 9620, 14030, 18440, 22850, norovirus Hu/GII.I2/CGMH42/20IO/TW

27260, 31670, 36080

801 VPI AGT3920G 801 5211 9621, 14031, 18441, 22851, norovirus Hu/GII.2/CGMH47/20ll/TW

27261, 31671, 36081

802 VPI AHF4599I 802 5212 9622, 14032, 18442. 22852. norovirus Hu/GII.4/Taipei/06-AM-ll/2006/TW

27262, 31672. 36082

803 VPI AHF45993 803 5213 9623, 14033, 18443, 22853, norovirus Hu/GII.4/kaohsiung/l2-AY- 27263, 31673. 36083 I/20I0/TW

804 VPI AHP45997 804 5214 9624. 14034, 18444, 22854, noravirus Hu/GII.4/Penghu/l2-BQ-l/20l2/TW

27264, 31674, 36084

805 VPI AHF45999 805 5215 9625, 14035, 18445, 22855, norovirus Hu/GII.4/Tainan/l2-CD-2- 27265, 31675, 36085 4/2012/TW

SOB VPI AHF4G00I 80G 52IG 9626, 14036, 18446, 22856, norovirus Hu/GII.4/Changhua/l2-CG-2- 27266, 31676, 36086 4/2012/TW

807 VPI AHH4487G 807 5217 9627, 14037, 18447, 22857, norovirus Hu/GII.4/patient_A/20IO/USA

27267, 31677, 36087

808 VPI AHH44877 808 5218 9628, 14038, 18448, 22858, norovirus Hu/GII.4/patient_A/20IO/OSA

27268, 31678, 36088

809 VPI AHH44878 809 5219 9629, 14039, 18449, 22859, norovirus Hu/GII.4/patient_A/20fO/USA

27269, 31679, 36089 SID VPI AHH44879 810 522D 963D, 14040. 18450, 22860, norovirus Hu/GII.4/patiEnt_A/20IO/USA

27270, 31680, 36090

en VPI AHH44880 811 5221 9631, 14041, 18451, 22861, norovirus Hu/Bli.4/patient_A/2DfO/USA

27271, 31681, 36091

812 VPI AHH4488I 812 5222 9632, I4D42, 18452, 22862, norovirus Hu/GII.4/patiEnt_A/20IO/USA

27272, 31682, 36092

813 VPI AHH44884 813 5223 9633, 14043, 18453, 22863, norovirus Hu/GII.4/patient_A/20IO/USA

27273, 31683, 36093

814 VPI AHH44886 814 5224 9634, 14044, 18454, 22864, norovirus Hu/GII.4/patient_C/20IO/USA

27274, 31684.36094

815 VPI AHH44888 815 5225 9635, 14045, 18455, 22865, norovirus Hu/GII.4/patient_C/20IO/USA

27275, 31685, 36095

816 VPI AHH44889 816 5226 9636, 14046, 18456, 22866. norovirus Hu/GII.4/patient_C/20IO/USA

27276, 31686, 36096

817 VPI AHH44890 817 5227 9637, 14047, 18457, 22867, norovirus Hu/GII.4/patient_C/2DfD/USA

27277, 31687.36097

818 VPI AHH4489I 818 5228 9638. 14048. 18458, 22868, noravirus Hu/GII.4/patient_C/20ID/USA

27278, 31688, 36098

819 VPI AHH44893 819 5229 9639, I4D49, 18459, 22869, norovirus Hu/GII.4/patiant_C/2DID/USA

27279, 31689, 36099

820 VPI AHH44894 820 5230 9640, 14050, 18460. 22870. norovirus Hu/GII.4/patient_C 2DID/USA

27280.31690, 36100

82! VPI AHH44895 821 5231 9641, 14051, 18461, 22871, norovirus Hu/GII.4/patient_C/2QI0/USA

27281, 31691, 36101

822 VPI AHH44896 822 5232 9642, I4D52, 18462, 22872, norovirus Hu/GII.4/patiEnt_A+5mo/20IO/USA

27282, 31692, 36102

823 VPI AHH44897 823 5233 9643, 14053, 18463, 22873. norovirus Hu/GII.4/patient 5mo/20IO/USA

27283, 31693, 36103

824 VPI AHH44899 824 5234 9644, 14054, 18464, 22874. norovirus Hu/GII.4/patient 5mo/20IO/OSA

27284.31694, 36104

825 VPI AHH44900 825 5235 9645. 14055, 18465, 22875, norovirus Hu/GII.4/patient 5mo/20IO/USA

27285, 31695, 36105

826 VPI AHH44902 826 5236 9646, 14056, 18466, 22876, norovirus Hu/GII.4/patiBnt_A+5mn/20ID/USA

27286, 31696, 36106 827 VPI AHH44BD4 827 5237 9B47. 14057, I84B7, 22877, narovirus Hu/GII.4/patient 5mo/2010/USA

27287, 3IB97, 3BI07

828 VPI AHH449D5 828 5238 9B48, 14058, I84B8, 22878, norovirus Hu/GII.4/patient 5rno/20IO/USA

27288, 3IB98, 3B108

820 VPI AHH449DB 829 5230 9B49, 14059, I84B0. 22879, narnvirus Hu/GII.4/patient_B/20IQ/USA

27289, 31699.3BI0G

830 VPI AHH449D7 830 5240 9650, 14060, 18470, 22880, narovirus Hu/GII.4/patient_B/20IO/USA

27290, 3I7D0, 36110

831 VPI AHH449D8 831 5241 9651, 14061, 18471, 22881, norovirus Hu/GII.4/patient_B/20ID/USA

27291, 31701, 3BIII

832 VPI AHH449D9 832 5242 9652. 14062, 18472, 22882, narovirus Hu/GII.4/patiEnt_B/20IO/USA

27292, 3I7D2, 36112

833 VPI AHH449II 833 5243 9653. I40B3, 18473, 22883, narovirus Hu/GII.4/patient_B/2DI0/USA

27293, 31703, 36113

834 VPI AHH44912 834 5244 9654, 14064, 18474, 22884. norovirus Hu/GII.4/patient_B/20IO/USA

27294.31704, 36114

835 VPI AHH449I3 835 5245 9655, 14065, 18475, 22885, norovirus Hu/GII.4/patient_B/Z0ID/USA

27295, 31705, 36115

83G VPI AHH449I4 83B 524B 9B56. I40B6, I847B, 22886, norovirus Hu/GII.4/patient_B/2DID/USA

2729B, 31706, 36116

837 VPI AHH449I5 837 5247 9657, 14067, 18477, 22887, norovirus Hu/GII.4/patient_B/20l0/0SA

27297, 31707, 36117

838 VPI AI0B0853 838 5248 9658. 14068, 18478, 22888, norovirus Hu/GII.4/Beijing/PK0PH-02- 27298, 31708, 36118 Ot/inpatiBnt/2012/CHN

839 VPI AIDBD855 839 5240 9659, 14069, 18479, 22889, norovirus Hu/GII.4/Beijing/PKUPH-02- 27299, 31709, 36119 02/inpatient/20l2/CHN

84D VPI AIDB0857 840 5250 9660. 14070. 18480, 22890, norovirus Hu/GII.4/Beijing/PKUPH-02- 27300, 31710, 36120 03/inpatient/20l2/CHN

841 VPI AIDBD859 841 5251 9661. 14071, 18481, 22891, norovirus Hu/GII.4/B _B ijing/PK0PH-02- 273DI, 31711.36121 D4/inpatiBnt/20l3/CHN

842 VPI AIDBD8BI 842 5252 9662. 14072, 18482, 22892, norovirus Hu/GII.4/Beijing/PK0PH-02- 27302, 31712, 36122 05/inpatient/2OI3/CHN

843 VPI AIDBD8B3 843 5253 9663, 14073. 18483, 22893, norovirus Hu/GII.4/Baijing/PKUPH-D2- 27303.31713, 36123 OB/inpatient/2013/CHN 844 VPI AID60865 844 5254 9664, I4D74, 18484. 22894, norovirus Hu/GII.4/Beijing/PKUPH-02- 27304, 31714, 36124 Q7/inpatient/20l3/CHN

845 VPI AID6086B 845 5255 9665. 14075, 18485. 22895, norovirus Hu/GII.4/Beijing/PKUPH-02- 27305, 31715, 36125 09/inpatiBnt/20l3/CHN

846 VPI AID6087I 846 5256 9666, 14076, 18486, 22896, norovirus Hu/GII.4/Beijing/PKUPH-05- 27306, 31716.36126 OI/inpatiEnt/2013/GHN

847 VPt AID60875 847 5257 9667, 14077, 18487, 22897, norovirus Hu/GII.4/Beijing/P UPH-DS- 27307, 31717, 36127 03/inpatiEnt/20l3/CHN

848 VPI AID60877 848 5258 9668, 14078, 18488. 22898, norovirus Hu/GII.4/Beijing/PKUPH-05- 27308, 31718, 36128 04/inpatient/20l3/CHN

849 VPI AID60879 849 5259 9669, 14079, 18489, 22899, norovirus Hu/GII.4/Beijing/PKUPH-05- 27309, 31719, 36129 05/inpatient/20l3/CHN

850 VPI AID6088I 850 5260 967D, I408D, 18490, 22900, norovirus Hu/GII.4/Beijing/P UPH-D5- 27310, 31720, 36130 OG/inpatient/2013/CHN

851 VPI AID60883 851 5261 9671, 14081, 18491, 22901, norovirus Hu/GII.4/Beijing/PKUPH-05- 27311, 31721, 36131 07/inpatient/20l3/CHN

852 VPI AI060885 852 5262 9672, 14082, 18492, 22902, norovirus Hu/GII.4/Beijing/P UPH-07- 27312, 31722, 3GI32 01/inpatient/2013/CHN

853 VPI AID60887 853 5263 9673, 14083, 18493, 22903, norovirus Hu/BII.4/Beijing/PKUPH-07- 27313, 31723, 36133 02/inpatiBnt/20l3/CHN

854 VPI AI060889 854 5264 9674, 14084. 18494, 22904, norovirus Hu/GII.4/Beijing/PKUPH-07- 27314, 31724, 36134 03/inpatient/20l3/CHN

855 VPI AID60893 855 5265 9675, 14085, 18495, 22905, norovirus Hu/GII.4/Beijing/PKUPH-B7- 27315, 31725, 36135 05/inpati_nt/20l3/CHN

856 VPI AID68577 856 5266 9676, 14086, 18486, 22906, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27316, 31726, 36136 244

857 VPI AID68578 857 5267 9677, 14087, 18497, 22907, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27317, 31727, 36137 246

858 VPI AID68579 858 5268 9678, 14088, 18498, 22908, norovirus GII/Hu/HKG/2DI4/GII.4/CUHK-NS- 27318.31728, 36138 250

850 VPI AID6858I 859 5269 9679, 14089, 18499, 22909, norovirus GII/Hu/HKG/20l3/GII.4/CUHK-NS- 27319.31729, 36139 141

860 VPI AID69I74 860 5270 9680, 14090, 18500, 22910, bat norovirus

27320, 31730, 36140 8BI VPI AIB5B994 8BI 527I 9B8I, I409I, I850I, 229II, norovirus Hu/GII.4/Beijing

27321, 3I731, 3BI4I

8B2 VPI AIG5999B 8B2 5272 9B82, I4092, I8502. 229I2, norovirus Hu/GII.4/Beijing

27322. 3I732. 3BI42

863 PI AIG59998 8B3 5273 9B83, I4093, I8503. 229I3, nomvirus Hu/GII.4/Beijing

27323, 3I733, 3BI43

8B4 VPI AIGBDDDD 8B4 5274 9B84, I4094, I8504, 229I4, norovirus Hu/GII.4/Beijing

27324, 3I734, 3BI44

865 VPI AIGBQQD2 8B5 5275 9B85, I4095, I8505, 229I5, nomvirus Hu/GII.4/Beijing

27325, 3I735. 3BI45

8BB VPI AIGBDDD4 8BB 527B 9B8B, I409B. I850B, 229IB, norovirus Hu/GII.4/Beijing

2732B, 3I73G, 3BI4B

8B7 VPI AIGBDODB 8B7 5277 9B87, I4097, I8507, 229I7, norovirus Hu/GII.4/Beijing

27327, 3I737, 3BI47

8B8 VPI AIGBD0D8 8B8 5278 9688. I4098. I8508. 229I8, norovirus Hu/GII.4/BBijing

27328, 3I738, 3BI48

8BB PI AIGBDDIO 8B9 5279 9B89, I4099, I85D9, 229I9, norovirus Hu/GII.4/Beijing

27329, 3I739, 3BI49

87D PI AIGBDDI2 87D 5280 9B9Q, I4IDD, I85I0, 22920, norovirus Hu/GII.4/Beijing

27330, 3I740, 3BI50

87I VPI AIGBQ0I4 87I 528I 9B9I, I4I0I, I85II. 2292I. norovirus Hu/GII.4/Beijing

27331, 3I741, 3BI5I

872 PI AIGBDDIB 872 5282 9BB2, 14102. 18512, 22922, norovirus Hu/GII.4/Beijing

27332. 31742. 3BI52

873 VPI AIGBDDI8 873 5283 9B93. 14103, 18513, 22923, norovirus Hu/GII.4/Beijing

27333, 31743, 3BI53

874 VPI AIGB0G2G 874 5284 9B94, 14104, 18514, 22924, norovirus Hu/GII.4/BBijing

27334. 31744, 3BI54

875 VPI AIGB0022 875 5285 9B95, 14105, 18515, 22925, norovirus Hu/GII.4/Beijing

27335, 31745, 3BI55

87B VPI AIGBD024 87B 528B 9B9B, I4I0B, I85IB, 2292B, norovirus Hu/GII.4/Beijing

27336. 3I74B, 3BI5B

877 VPI AII737I7 877 5287 9B97, 14107. 18517, 22927, norovirus

27337, 31747, 3BI57 GII/Hu/JP/2002/GII.PI2_GII.I3/Saitama/T80 878 VPI AII7372D 878 5288 9B98, 14108, 18518, 22928, norovirus

27338, 31748, 3BI58 GII/Hu/JP/200l/GII.P22_GII,5/Saitama/T49

873 VPI AII73723 879 5289 3639, 14109, 18519, 22929, norovirus

27339, 31749, 3BI53 GII/Hu/JP/2007/GII.P7_GII.I4/SBndai/YG99

88D VPI AII7372B 880 5290 9700, 14110. 18520, 22930, norovirus GII/Hu/JP/20!2/GII.Pe_GII.4_

27340, 31750, 3BIB0 Sydney2DI2/Fukuyama/3

881 VPI AII73729 881 5291 37DI, 14111, 18521, 22931, 27341, norovirus GII/HU/JP/20I2/GII.PB_GII.4_

31751, 3BIBI Sydney20l2/Fukuyama/2

882 VPI AII73732 882 5292 9702, 14112, 18522, 22932, norovirus GII/Hu/JP/20l2/GII.Pe_GII.4_

27342, 31752, 3BIB2 Sydn_y20l2/Fukuyama/5

883 VPI AII73735 883 5293 9703, 14113. 18523, 22933, norovirus

27343, 31753, 3BIB3 GII/Hu/JP/200l/GII.PI2_GII.I2/Saitama/TI5

884 VPI AII73738 884 5294 3704. 14114. 18524, 22934, norovirus GII/Hu/TW/2012/GII.Pe_GII.4_

27344. 31754, 3BIB4 Sydney20l2/Taipei/I06

885 VPI AII7374I 885 5295 9705, 14115, 18525, 22335, norovirus

27345, 31755, 3BIB5 GII/Hu/JP/2007/GII.P2l_GII.2l/Kawasaki/Y02

84

88B VPI AII73744 88B 529B 370B, I4IIG. I852B, 2293B, norovirus GII/Hu/TW/20l2/GII.Pe_GII.4_

27346, 31756. 3BIB6 Sydney20l2/Tai _P Bi/l08

887 VPI AII73747 887 5297 9707, 14117. 18527, 22937. norovirus

27347, 31757, 3GIB7 GII/Hu/JP/2002/GII.PIG_GII.I7/Saitama/T87

888 VPI AII7375D 888 5298 9708, 14118. 18528. 22938, norovirus

27348, 31758, 3BIB8 GII/Hu/JP/20IO/GII.P4_GII.4/Shimada/ASC9G

889 VP! AII73753 889 5299 9709, 14119, 18529, 22939, norovirus

27349, 31759, 36169 GII/Hu/JP/2002/GII.P5_GII.5/Saitama/T52

89D VPI AII7375B 89D 5300 9710, 14120. 18530, 22940, norovirus GII/Hu/TW/20l2/GII.Pe_GII.4_

27350, 31760, 36170 Sydney20l2/Taipei/I09

891 VPI AII73753 891 5301 9711, 14121, 18531, 22941, 27351, norovirus

31761, 36171 GII/Hu/JP/2007/GII.PI5_GII.I5/Sapporo/HK2

99

892 VPI AII737B2 892 5302 9712, 14122, 18532, 22942, norovirus

27352, 31762, 36172 GII/Hu/JP/20ll/GII/Yuzawa/Gira2HS 893 VPI AII737G5 893 5303 9713. 14123, 18533. 22943, narovirus

27353, 31763, 36173 GI/Hu/JP/2007/GI.P3_GI.3/Shimizu/ K2866

894 VPI AII737G8 894 5304 9714, 14124, 18534. 22944, narovirus GII/HU/JP/2D12/GII.PB_GII.4_

27354, 31764, 36174 SydnBy2DI2/Fukuyama/l

895 VPI AII7377I 895 5305 9715. 14125, 18535, 22945, narovirus

27355, 31765, 36175 GII/Hu/JP/2000/GII.PI2_GII.I2/Saitama/ UIG

896 VPI AII73774 89G 530G 9716, 14126, 18536, 22946, narovirus 6ll/Hu/JP/20IO/GII.P7_GII.7/

27356, 31766, 36176 Musashimurayama/TAKAsanKimchi

897 VPI AII73777 897 5307 9717, 14127, 18537, 22947, narovirus GII/HU/TW/20I2/GII.PB_GII.4_

27357, 31767, 36177 SydnEy20l2/Taipei/l05

898 VPI AII73780 898 5308 9718, 14128, 18538, 22948. narovirus

27358. 31768, 36178 GII/Hu/JP/2007/GII.P7_GII.I4/Fukuoka/KK28

2

899 VPI AII73783 899 5309 9719, 14129, 18539, 22949, norovirus

27359. 31769, 36179 GI/Hu/JP/2007/GI.P8_GI.8/Nagoya/KY53l

9D0 VPI AII7378G 900 5310 9720. 14130, 18540, 22950, narovirus

27360, 31770, 36180 GII/Hu/JP/200l/GII.PI2_GII.I2/Saitama/TI8

301 VPI AIS400I9 901 5311 9721, 14131, 18541, 22951, norovirus Hu/Gli.4/S JTUHI/CHN/2014

27361, 31771. 36181

902 VPI AIV43I47 902 5312 9722. 14132, 18542, 22952. norovirus GII.4

27362, 31772, 36182

903 VPI AIV43I48 903 5313 9723, 14133, 18543, 22953, narovirus GII.4

27363, 31773, 36183

9D4 VPI AIV43I49 904 5314 9724, 14134, 18544, 22954, narovirus GII.4

27364, 31774, 36184

905 VPI AIV43I50 905 5315 9725, 14135, 18545, 22955, norovirus GII.4

27365, 31775, 36185

90G VPI AIV43I5I 90G 5316 9726, 14136, 18546, 22956, narovirus GII.4

27366, 31776, 36186

907 VPI AIV43I52 907 5317 9727, 14137, 18547, 22957, norovirus GII.4

27367, 31777, 36187

908 VPI AIV43I53 908 5318 9728, 14138, 18548, 22958, norovirus GII.4

27368, 31778, 36188 D9 PI AIV43I54 909 5319 9729. 14139. 18549, 22959, norovirus GII.4

273B9, 31779, 36189

9ID VPI AIV43I55 910 5320 9730, 14140, 18550, 22960, norovirus GII.4

27370, 31780, 3BI90

911 VPI AIV43156 911 5321 9731, 14141, 18551, 229GI, norovirus Gil.4

27371, 31781, 3GI9I

912 VPI AIV43I59 912 5322 9732. 14142, 18552, 229G2, norovirus GII.4

27372, 31782.36192

913 PI AIV43IG0 913 5323 9733. 14143. 18553, 22963. nnrovirus GII.4

27373, 31783, 36193

914 PI AIV43IBI 914 5324 9734, 14144, 18554, 229G4, norovirus GII.4

27374, 31784, 36194

915 VPI AIV43IG2 915 5325 9735, 14145, 18555, 22965, norovirus GII.4

27375, 31785, 36195

916 VPI AIV43IB3 9IB 532B 973B, I4I4B, I855G, 229G6, norovirus GII.4

27376, 31786, 3BI9B

917 VPI AIV43IB4 917 5327 9737. 14147, 18557, 22967, norovirus GII.4

27377, 31787, 36197

918 VPI AIV43IB5 918 5328 9738, 14148. 18558, 22968, norovirus GII.4

27378.31788, 36198

919 VPI A1V43IBB 919 5329 9739, 14149, 18559, 22969, norovirus GII.4

27379, 31789, 3BI99

920 VPI AIV43IB7 920 5330 9740, 14150, I85G0, 22970, norovirus GII.4

27380, 31790, 36200

921 VPI AIV43I7I 921 5331 9741, 14151, 18561. 22971, norovirus GII.4

27381, 31791. 36201

922 VPI AIV43I72 922 5332 9742, 14152, 18562, 22972, norovirus GII.4

27382, 31792, 3G202

923 VPI AIV43I73 923 5333 9743, 14153, 18563, 22973, norovirus GII.4

27383, 31793, 3G2D3

924 VPI AIV43I74 924 5334 9744, 14154, 18564, 22974, norovirus GII.4

27384, 31794, 36204

925 VPI AIV43I75 925 5335 9745, 14155, 18565, 22975, norovirus GII.4

27385, 31795, 36205 926 VPI AIV43I7B 926 5336 9746, 14156. 18566, 22976, narovirus GII.4

27386, 31796, 36206

927 VPI AIV43I77 927 5337 9747, 14157, 18567, 22977, norovirus GII.4

27387, 31797, 36207

928 VPI AIV43I78 928 5338 9748, 14158, 18568, 22978, norovirus GII.4

27388, 31798, 362D8

929 VPI AIV43I7B 929 5339 9749, 14159, 18569, 22979, norovirus GII.4

27389, 31799, 362D9

930 PI AIY27747 93D 5340 9750, 14160, 18570, 22980, naravipus Hu/GII.4/variant Sydney 2012/FRA

27390, 31800, 36210

931 PI AJA7I387 931 5341 9751, 14161, 18571, 22981, narovirus GII/Hu/HKG 2014/GII UHK-NS- 27391, 31801, 36211 337

932 VPI AJA7I388 932 5342 9752, 14162. 18572, 22982, narovirus GII/Hu/HKG/2DI4/GII.4/CUHK-NS- 27392, 31802, 36212 340

933 VPI AJA7I389 933 5343 9753, 14163, 18573, 22983. norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27393, 3I8D3, 36213 342

934 VPI AJA7I390 934 5344 9754, 14164, 18574, 22984, narovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27394.31804, 36214 345

935 VPI AJA7I392 935 5345 9755, 14165, 18575. 22985, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27395, 31805, 36215 348

93B VPI AJA7I393 936 5346 9756, 14166, 18576, 22986, norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 27396. 31806.36216 349

937 VPI AJA7I394 937 5347 9757. 14167, 18577, 22987, narovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27397, 31807, 36217 350

938 VPI AJA7I395 938 5348 9758, 14168, 18578, 22988, norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 27398, 31808, 36218 351

939 VPI AJA7I39G 939 5349 9759, 14169, 18579, 22989, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27399, 31809, 36219 354

940 VPI AJA7I399 940 5350 9760. 14170, 18580, 22990, narovirus GII/Hu/HKG/2DI4/GII.4/CUHK-NS- 27400, 31810, 36220 358

941 VPI AJA7I400 941 5351 9761, 14171, 18581, 22991, norovirus GII/Hu/HKG/2DI4/GII.4/CUHK-NS- 27401, 31811. 36221 359

942 VPI AJA7I40I 942 5352 9762. 14172, 18582, 22992, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27402, 31812, 36222 361 943 PI AJA7I4D2 943 5353 3763, 14173. 18583, 22993, nomvirus GII/Hu/HKG/2DI4/GII.4/C0HK-NS- 274D3, 31813, 36223 362

944 VPI AJA7I4D3 944 5354 9764, 14174, 18584. 22994, norovirus Gli/Hu/HKG/2DI4/Gl 1.4/CUHK-NS- 27404, 31814, 36224 363

945 VPI AJA7I4D4 945 5355 9765, 14175, 18585, 22995, norovirus GII/Hu/H G/20l4/GII.4/CUHK-NS- 274D5, 31815, 36225 364

94G VPI AJA7I405 94G 5356 9766, 14176, 18586, 22996, norovirus GII/Hu/HKG/2014/GII UHK-NS- 274D6, 31816, 36226 365

947 VPI AJA7I4DB 947 5357 9767, 14177, 18587, 22997, norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 274D7.31817, 36227 3G7

948 VPI AJA7I4D7 948 5358 9768, 14178, 18588, 22998, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27408, 31818, 36228 369

949 VPI AJA7I408 949 5353 9769, 14179. 18589, 22999, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 27409. 31819. 36229 370

950 VPI AJA7I409 95D 53G0 9770, 14180, 18590, 23000, norovirus Hu/GII/HKG/ZOI4/GII.4/CUH -NS- 27410.31820, 36230 368

951 VPI AJA7I4I0 951 53GI 9771, 14181, 18591,23001.27411, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 31821, 36231 372

952 VPI AJA7I4II 952 53G2 9772, 14182, 18592, 23002, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27412, 31822, 36232 374

953 VPI AJA7I4I2 953 53G3 9773, 14183, 18593, 23003, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27413, 31823, 3G233 377

954 VPI AJA7I4I3 954 53G4 9774, 14184, 18594, 23004, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27414, 31824, 36234 378

955 VPI AJA7I4IB 955 5365 9775, 14185. 18595, 23005, norovirus Hu/GII/H G/2DI4/GII.4/CUH -NS- 27415, 31825, 36235 384

95E VPI AJA7I4I7 95B 5366 9776, 14186, 18596, 23006, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 27416, 31826, 36236 385

957 VPI AJA7I4I8 957 5367 9777, 14187, 18597, 23007, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 27417, 31827, 36237 386

958 VPI AJA7I4I9 358 5368 9778. 14188. 18598, 23008, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27418, 31828, 36238 387

959 VPI AJA7I420 353 5369 9779, 14189, 18599, 23009, norovirus Hu/GII/HKG/2DI4/GII.4/CUH -NS- 27419, 31829, 36239 389 960 VPI AJA7I42I 960 5370 9780. 14190. 18600, 23010, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 27420.31830.36240 393

961 VPI AJA7I422 961 5371 9781, 14191, 18001, 23DII, 27421, norovirus Hu/GII/H G/20l4/GII.4/CUHK-NS- 31831, 36241 394

902 VPI AJA7I423 962 5372 9782, 14192, 18602, 23012, norovirus Hu/GII/HKG/ZDI4/GII.4/CUH -NS- 27422, 31832, 36242 395

963 VPI AJA7I424 963 5373 9783, 14193. 18603, 23013, norovirus Hu/GII/HKG/20l4/GII.4/C0HK-NS- 27423, 31833, 36243 396

964 VPI AJA7I425 964 5374 9784, 14194, 18604, 23014, norovirus Hu/GII/H G/20l4/GII.4/CUH -NS- 27424, 31834, 36244 397

965 VPI AJA7I426 965 5375 9785, 14195, 18605, 23015, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27425, 31835.36245 398

966 VPI AJA7I427 966 5376 9786, 14196, 18606, 23016, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 27426, 31836, 36246 399

967 VPI AJA7I428 967 5377 9787, 14197, 18607, 23017, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27427, 31837, 36247 402

968 VPI AJA7I429 968 5378 9788, 14198, 18608, 23018, norovirus Hu/GII/H G/ZOI4/GII.4/CUH -NS- 27428, 31838, 36248 404

969 VPI AJA7I430 969 5379 9789, 14199, 18609, 23010, norovirus Hu/BH/H B/2014/Glf .4/CUHK-NS- 27429, 31839, 36249 406

970 VPI AJA7I456 970 5380 9790. 14200. 18610. 23D20, norovirus Hu/GII/HKG/20l4/GII.4/C0HK-NS- 27430, 31840.36250 426

971 VPI AJA7I457 971 5381 9791, 14201, 18611, 23021, norovirus Hu/GII/HKG/20l4/GII.4/C0HK-NS- 27431, 31841, 36251 341

972 VPI AJA7I458 972 5382 9792, 14202, 18612, 23022, norovirus Hu/GII/H G/ZDI4/GII.4/CUH -NS- 27432, 31842, 36252 346

973 VPI AJA7I459 973 5383 9793, 14203, 18613, 23023, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27433, 31843, 36253 352

974 VPI AJA7I460 974 5384 9794, 14204, 18614, 23024, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27434, 31844, 36254 356

975 VPI AJA7I46I 975 5385 9795, 14205, 18615, 23025, norovirus Hu/GII/HKG/20l4/GII.4/CU ^' HK-NS- 27435, 31845, 36255 371

976 VPI AJA7I462 976 5386 9796, 14206, 18616, 23026, norovirus Hu/GII/H G/20l4/GII.4/CUHK-NS- 27436, 31846, 36256 376 977 VPI AJA7I4B3 977 5387 9797. 14207, 18617, 23027, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 27437, 31847, 3B257 379

978 VPI AJA7I4B4 978 5388 9798, I42D8, I8GI8, 23028, norovirus HU/GII/H G/ZDI4/GII.4/CUHK-NS- 27438, 31848, 3B258 407

979 VPI AJA7I4B5 979 5389 9799, 14209, I8BI9, 23029, norovirus Hu/GII/H G/ZOI4/GII.4/CUH -NS- 27439, 31849, 3B259 412

98D VP! AJA7I4BB 980 5390 9800, 14210, I8B20, 23030, noravirus Hu/GII/HKG/ZDI4/GII.4/CUHK-NS- 27440, 31850, 3B2B0 415

981 VPI AJA7I4G7 981 5391 9801, 14211, I8B2I, 23031, norovirus Hu/GII/HKG/ZOI4/GII.4/CUH -NS- 27441, 31851, 3B2BI 416

982 VPI AJA7I470 982 5392 9802, 14212, I8G22. 23032, norovirus Hu/GII/H G/ZDI4/GII.4/CUHK-NS- 27442, 31852, 3B2B2 420

983 VPI AJA7I47I 983 5393 9803, 14213, I8B23, 23033, norovirus Hu/GII/HKG/20l4/GII.4/CUH -NS- 27443, 31853, 3B2B3 421

984 VPI AJA7I472 984 5394 9804, 14214, I8B24, 23D34. norovirus Hu/GII/HKG/20l4/GII.4/CUH -NS- 27444, 31854, 3B2B4 429

985 VPI AJA7I473 985 5395 9805, 14215, I8B25, 23035, norovirus Hu/GII/H G/20l4/GII.4/CUHK-NS- 27445, 31855, 3G2B5 430

98B VPI AJA7I474 98B 539B 980B, I42IB, I8B2B, 2303B, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 2744B, 3I85B, 3B2BB 431

987 VPI AJA7I475 987 5397 9807, 14217, I8B27, 23037, norovirus Hu/GII/HKG/2DI4/GII.4/CUHK-NS- 27447, 31857, 3B2B7 433

988 VPI AJA7I47B 988 5398 9808, 14218, I8B28, 23038, norovirus Hu/Gll/HKB/2014/Gl I.4/CUHK-NS- 27448, 31858, 3B2B8 435

989 VPI AJF2I974 989 5399 9809, 14219, I8B29, 23039, norovirus GII.4

27449, 31859, 3B2B9

990 VPI AJF2I975 990 5400 9810, 14220, I8B30, 23040, norovirus GII.4

27450, 3I8B0.3B270

991 VPI AJF2I97B 991 5401 9811, 14221, 18631. 23041, norovirus GII.4

27451, 31861, 36271

992 VPI AJF2I977 992 5402 9812, 14222, 18632, 23042, norovirus GII.4

27452.31862.36272

993 VPI AJF2I978 993 5403 9813, 14223, 18633, 23043, norovirus GII.4

27453. 31863.36273 B94 VPI AJF2I979 994 54D4 9814, 14224, I8B34, 23D44, norovirus GII.4

27454, 3I8G4, 3B274

995 VPI AJF2I980 995 5405 9815, 14225, I8B35, 23045, narovirus GII.4

27455, 3I8B5, 3B275

99B VPI AJF2I98I 99B 540B 98IB, I422B, I8B3B, 2304B, norovirus GII.4

2745B, 3I8BB, 3B27B

997 VPI AJF2I982 997 5407 9817, 14227, I8B37, 23D47, noravirus GII.4

27457, 3I8B7, 3B277

998 VPI AJF2I983 998 5408 9818, 14228, I8B38, 23048, narovirus GII.4

27458, 3I8B8, 3B278

999 VPI AJF2I984 999 5409 9819, 14229, I8B39, 23D49, norovirus GII.4

27459, 3I8B9, 3B279

IDDO VPI AKE37037 IODO 5410 9820, 14230, I8B40, 23050, noravirus

274BD, 31870.3B28D Hu/GII.I7/4IB2l/Guangzhou/20l4/CHN

1001 VPI A M2D8I5 1001 5411 9821, 14231, 18641. 23051, norovirus Gl

274BI, 31871.3B28I

1002 VPI A M208I8 1002 5412 9822, 14232, I8B42, 23052, norovirus Gl

274B2, 31872, 3B282

1003 VPI ALD83748 1003 5413 9823, 14233, I8B43, 23053, norovirus

274B3, 31873, 3B283 GII/Hu/H G/20l5/GII.Pe_GII.I7/CUHK-NS-B82

1004 VPI ALFI2528 1004 5414 9824, 14234. I8B44, 23054. norovirus Gil

274B4, 31874.3B284

1005 VPI ALFI2529 1005 5415 9825, 14235, I8B45, 23055, norovirus Gil

274B5, 31875, 3B285

I00B VPI ALFI2530 IOOB 54IB 982B, I423B, I8B4B. 23D5B, norovirus Gil

274BB, 3I87B.3B28G

1007 VPI ALFI253I 1007 5417 9827, 14237, I8B47, 23057, norovirus Gil

274B7, 31877, 3B287

1008 PI ALFI2532 ID08 5418 9828, 14238, I8B48, 23D58, norovirus Gil

274B8, 31878, 3B288

1009 VPI ALFI2533 1009 5419 9829, 14239, I8B49, 23059, norovirus Gil

274B9, 31879, 3B289

1010 VPI ALFI2534 1010 5420 9830, 14240, I8B50. 230B0, noravirus Gil

27470, 31880, 3B290 ιοιι VPI ALFI2535 1011 5421 9831, 14241, 18651, 230GI, norovirus Gil

27471. 31881, 36291

1012 VPI ALFI253B 1012 5422 9832, 14242, 18652, 23062, norovirus Gil

27472. 31882, 36292

1013 PI ALFI2537 1013 5423 9833, 14243, 18653, 23063. norovirus Gil

27473, 31883, 36293

1014 VPI ALFI2538 1014 5424 9834, 14244, 18654, 230B4, norovirus Gil

27474, 31884, 3B294

1015 VPI ALFI2539 1015 5425 9835, 14245, 18655, 230B5, norovirus Gil

27475, 31885, 36295

1016 VPI ALFI254I 1016 5426 9836. 14246, 18656, 230B6, norovirus Gil

27476, 31886.36296

1017 VPI ALFI2542 1017 5427 9837, 14247. 18657, 23067, norovirus Gil

27477, 31887, 36297

1018 VPI ALFI2543 1018 5428 9838. 14248, 18658, 23068, norovirus Gil

27478, 31888, 36298

lO!B VPI ALFI254B 1019 5429 9839, 14249, 18659, 23069, norovirus Gil

27479, 31889, 36299

1020 VPI ALFI2547 1020 5430 9840, 14250, 18660, 23070, norovirus Gil

27480, 31890, 36300

1021 VPI ALFI25B0 1021 5431 9841, 14251, 18661, 23071, norovirus Gil

27481, 31891, 36301

1022 VPI ALFI25B2 1022 5432 9842. 14252. 18662, 23072, norovirus Gil

27482, 31892, 36302

ID23 VPI ALFI25B4 ID23 5433 9843, 14253, 18663, 23073, norovirus Gil

27483, 31893.36303

1024 VPI ALFI25BB 1024 5434 9844, 14254, 18664, 23074, norovirus Gil

27484, 31894, 3B304

1025 VPI ALFI25G9 1025 5435 9845, 14255, 18665, 23075. norovirus Gil

27485, 31895, 36305

I02B VPI ALQ287B2 I02B 5436 9846, 14256, 18666, 2307B. norovirus G 11.1 ^* 7

27486.3I89B, 3B306

1027 VPI ALS03883 ID27 5437 9847, 14257, I8BB7, 23077, norovirus Gil

27487, 31897, 36307 1D28 VPI ALT0B54B I028 5438 9848, I4258, I8BB8, 23078, norovirus Hu/GII,PI7_BII.I7/NSWB0!B/20l4/AU

27488, 3I838, 3B3D8

ID2B VPI BAG3D93B ID29 5439 9843, I4259, I8BB9, 23073, norovirus Hu/Texas/TCH04-577/2004/0S

27483, 3I83S.36309

I030 VPI BAG70428 I030 5440 3850, I42B0, I8B70, 2308D, norovirus Hu/GII-4/Hokksidol/ZDOB/JP

27430.3I900, 3B3I0

I03I VPI BAG7D43I I03I 544I 985I, I42BI, I8B7I, 2308I, norovirus Hu/GII-4/Hokkaido2/2006/JP

27491, 3I301, 3B3II

I032 VPI BAG7D434 ID32 5442 3852, I42B2, I8B72, 23082, norovirus Hu/GII-4/Hokkaido3/200B/JP

27432, 3I302.3B3I2

I033 VPI BAG7D437 ID33 5443 3853, I42B3, I8B73, 23083, norovirus Hu/GII-4/HDkkaido4/200B/JP

27433, 3I903, 3B3I3

ID34 VPI BAG7B44D ID34 5444 3854, I42B4, I8B74, 23084, norovirus Hu/GII-4/Hokkaido5/20DB/JP

27494, 3IB04.363I4

ID35 VPI BAG7D44B ID35 5445 3855, I42G5, I8B75, 23085, norovirus Hu/GII-4/ADmori2/200G/JP

27495, 3I905, 3B3I5

ID3B VPI BAG70449 I03B 544B 985B, I42BB, I8B7B, 2308B, norovirus Hu/GII-4/Aomori4/200G/JP

2749B, 3I90B, 3B3IB

ID37 VPI BAG7D452 ID37 5447 9857, I42B7, I8B77. 23087, norovirus Hu/GII-4/Aomori5/2006/JP

27497, 3I907, 3B3I7

I038 VPI BAB70458 I038 5448 3858, I42B8. I8B78, 23088, norovirus Hu/GII-4/Akita2/2006/JP

27438, 3I908, 3B3I8

I03B VPI BAB704BI I03B 5449 9859, I42B9, I8B79, 23089, norovirus Hu/GII-4/Akita4/200B/JP

27499, 3I909.363I9

ID4D VPI BAG7B4G4 I040 5450 98BD, I4270, I8B80, 23030, norovirus Hu/GII-4/Akita5/200B/JP

27500, 31910, 3B320

I04! VPI BAB704B7 I04I 545I 38BI, 14271, I8G8I, 23D3I, norovirus Hu/GII-4/Miyagi2/2006/JP

27501, 31011, 3B32I

ID42 VPI BAG70470 I042 5452 38B2, 14272, I8B82, 23032, norovirus Hu/GII-4/ iyagi4/2006/JP

27502, 31912, 3B322

I043 VPI BAG70473 I043 5453 98B3, 14273, I8B83, 23D93, norovirus Hu/GII-4/ iyagi5/2006/JP

27503, 31913, 3B323

ID44 VPI BAG7047B I044 5454 98B4, 14274, 18684, 23094, norovirus Hu/GII-4/Toyamal/2006/JP

27504, 31914, 36324 ID45 VPI BAG70482 1045 5455 38B5, 14275. I8B85, 23095, noravirus Hu/GII-4/Tnyama5/2006/JP

27505.31915, 3B325

1046 VPI BAG70485 I04G 545B 9866. 14276. 18686, 23096, narovirus Hu/GII-4/Aichi3/2Q06/JP

2750B, 31916, 36326

1047 VPI BAG70488 1047 5457 9867, 14277, 18687, 23D97, narovirus Hu/GII-4/Aichi4/2006/JP

27507, 31917, 36327

1048 VPI BAG7049I 1048 5458 9868, 14278, 18688, 23098, narovirus Hu/GII-4/Sakai2/2006/JP

27508, 31918.36328

1049 VPI BAG70494 1049 5459 9869, 14279, 18689. 23099, narovirus Hu/GII-4/Sakai3/2006/JP

27509, 31919, 3B329

1050 VPI BAG70497 1050 54G0 9870, 14280, 18690, 23100, narovirus Hu/GII-4/Sakai4/2006/JP

27510, 31920, 36330

1051 VPI BAG70503 1051 54GI 9871, 14281, 18691, 23101, norovirus Hu/GII-4/Hiroshima2/20D6/JP

27511, 31921, 36331

1052 VPI BAG7B50B 1052 54B2 9872, 14282, 18692, 23102, norovirus Hu/GII-4/Ehimel/200G/JP

27512, 31922, 3B332

1053 VPI BAG70509 1053 54B3 9873, 14283, 18693, 23103, narovirus Hu/GII-4/Ehime2/2006/JP

27513, 31923, 36333

1054 VPI BAG705I2 1054 54G4 9874. 14284, 18694, 23104, noravirus Hu/GII-4/Ehim _E 5/2006/JP

27514, 31924, 36334

1055 VPI BAG705I5 1055 54B5 9875, 14285, 18695, 23105, norovirus Hu/GII-4/Sagal/2Q06/JP

27515, 31925, 36335

I05G VPI BAG705I8 I05G 5466 9876, 14286, 18696, 23106, norovirus Hu/GII-4/Saga4/2006/JP

27516, 31926, 3633B

1057 PI BAG7052I 1057 5467 9877, 14287, 18697, 23ID7, noravirus Hu/GII-4/Saga5/200G/JP

27517, 31927, 36337

1058 VPI BAG70524 1058 5468 B878, 14288, 18698, 23108, norovirus Hu/GII-4/Kumamotol/200G/JP

27518, 31928, 36338

1059 VPI BAG70527 1059 5469 9879, 14289, 18699, 23109, norovirus Hu/GII-4/Kumamoto2/2006/JP

27519, 31929.36339

I0G0 VPI BAG7D530 IOGO 5470 9880, 14290. 18700. 23110, narovirus Hu/GII-4/Kumamata3/2006/JP

27520, 31930, 36340

I0GI VPI BAG70533 IOGI 5471 9881, 14291,18701,23111, 27521, norovirus Hu/GII-4/Kumamoto4/200G/JP

31931, 36341 IDB2 VPI BAG70536 I0B2 5472 9882, 14292, 18702, 23112, norovirus Hu/GII-4/Kumamoto5/2006/JP

27522, 31932, 3B342

I0B3 VPI BAI705I8 I0B3 5473 9883, 14293, 18703, 23113, norovirus Hu/GII-4/FUMI/20IO/JP

27523, 31933, 3B343

IDB4 VP! BAJI3508 I0B4 5474 9884, 14294, 18704, 23114, norovirus Hu/GII-4/2007a_0RF2-3/JP

27524, 31934, 3B344

I0B5 VPI BAJI35I3 IQ65 5475 9885, 14295, 18705, 23115, norovirus Hu/GII-4/2007b_DRF2-3/JP

27525, 31935, 3B345

I0BG VPI BAJI3520 IOBG 547B 988B, I429B, I870B, 23116, norovirus Hu/GII-4/2008a_0RF2-3/JP

2752B, 3I93B, 3B34B

I0B7 VPI BAJI3534 I0B7 5477 9887, 14297, 18707, 23117, norovirus Hu/GII-4/Aichil/2007/JP

27527, 31937, 3G347

I0BB VPI BAJI3537 I0B8 5478 9888, 14298, 18708, 23118. norovirus Hu/GII-4/Aichil/2008/JP

27528, 31938, 3G348

IDB9 VPI BAJI3540 I0G9 5479 9889, 14299, 18709, 23119, norovirus Hu/GII-4/Aichi2/2007/JP

27529, 31939, 3B349

I07D VPI BAJI3543 1070 5480 9890, 14300, 18710, 23120, norovirus Hu/GII-4/Aichi2/2008/JP

27530, 31940, 36350

ID7I VPI BAJI354B 1071 5481 9891, 14301, 18711. 23121, norovirus Hu/GII-4/Aichi3/2008/JP

27531, 31941, 36351

ID72 VPI BAJI3552 1072 5482 9892, 14302, 18712. 23122, norovirus Hu/GII-4/Aic i4/2007/JP

27532, 31942, 36352

ID73 VPI BAJI3555 1073 5483 9893, 14303, 18713, 23123, norovirus Hu/GII-4/Aichi4/2D08/JP

27533, 31943.36353

ID74 VPI BAJI3558 1074 5484 9894, 14304. 18714, 23124, norovirus Hu/GII-4/Aichi5/2007/JP

27534, 31944.3B354

1075 VPI BAJI35BI 1075 5485 B8B5. 14305. 18715. 23125, norovirus Hu/GII-4/Aichi5/2008/JP

27535, 31945, 36355

ID7B VPI BAJI35B4 I07B 548G 9896, I430B, 18716. 23126. norovirus Hu/GII-4/Akital/2007/JP

27536.3IB4B, 36356

1077 VPI BAJI35B7 1077 5487 9897, 14307, 18717, 23127, norovirus Hu/GII-4/Akital/2008/JP

27537, 31947, 36357

1078 VPI BAJI3573 I07B 5488 9898. 14308, 18718, 23128. norovirus Hu/GII-4/Akita3/2007/JP

27538, 31948, 3B358 ID79 VPI BAJI357B 1079 5489 98B9. 14309, 18719, 23129, nornvirus Hu/GII-4/Akita3/2008/JP

27539, 31949, 3B359

1080 VPI BAJI3579 1080 5490 9900, 14310, 18720, 23130, nornvirus Hu/GII-4/Akita4/2008/JP

27540, 31950, 3B3B0

1081 VPI BAJI3582 1081 5491 3901, 14311, 18721,23131, 27541, nornvirus Hu/GII-4/Akita5/2007/JP

31951, 3B3BI

1082 VPI BAJI3585 1082 5492 9902, 14312, 18722, 23132, norovirus Hu/GII-4/Aomoril/2007/JP

27542, 31952, 3B3B2

1083 VPI BAJI359I 1083 5493 9903, 14313, 18723, 23133, nDrovirus Hu/GII-4/ADmori2/2007/JP

27543, 31953, 3B3G3

1084 VPI BAJI3594 1084 5494 9904, 14314, 18724, 23134, nornvirus Hu/GII-4/Anmnri2/2008/JP

27544, 31954, 3B3B4

1085 VPI BAJI3597 1085 5495 9905, 14315, 18725, 23135, nornvirus Hu/GII-4/Aomori3/2007/JP

27545, 31955, 3B3B5

I08G VPI BAJI3B03 I08G 549B 990B, 14316, I872B, 23136, nnrnvirus Hu/GII-4/Anmori4/2007/JP

27546, 31956.363BB

1087 VPI BAJI3B0B 1087 5497 9907, 14317, 18727, 23137, nnrnvirus Hu/GII-4/AnmDri4/2008/JP

27547, 31957, 36367

1088 VPI BAJI3B09 1088 5498 9908, 14318, 18728, 23138, nnrnvirus Hu/GII-4/Aomnri5/2007/JP

27548, 31958, 36368

1089 PI BAJI3BI2 1089 5499 9909. 14319, 18729, 23139, nnrnvirus Hu/GII-4/Anmnri5/2008/JP

27549, 31959, 36369

1090 VPI BAJI3BI5 1090 5500 9910, 14320, 18730, 23140. nnrnvirus Hu/GII-4/Chibal/2Q07/JP

27550, 31960, 3B370

1091 VPI BAJI3BI8 1091 5501 9911, 14321.18731, 23141.27551, nnrnvirus Hu/GII-4/Chibal/2008/JP

31961, 36371

ID92 VPI BAJI362I 1092 5502 9912, 14322, 18732, 23142, nornvirus Hu/GII-4/Chiba2/2007/JP

27552, 3I9G2, 36372

1093 VPI BAJI3B24 1093 5503 9913, 14323, 18733, 23143, norovirus Hu/GII-4/Chiba2/2008/JP

27553, 31963, 36373

1094 VPI BAJI3B27 1094 5504 9914, 14324, 18734, 23144, norovirus Hu/GII-4/Chiba4/2007/JP

27554, 31964, 36374

1095 PI 8AJI3B30 1095 5505 9915, 14325, 18735, 23145, norovirus Hu/GII-4/Chiba4/2008/JP

27555, 31965, 36375 I09B VPI BAJI3B33 I03B 550B 99IB, I432B, I873B, 23I4B, norovirus Hu/GII-4/Chiba5/2DD7/JP

2755B, 3I9BB, 3B37B

ID97 VPI BAJI3B3B I0B7 5507 9917. 14327. 18737, 23147, narovirus Hu/GII-4/Chiba5/2008/JP

27557, 3I9B7, 3B377

IDB8 VPI BAJI3B39 1098 5508 9918, 14328, 18738, 23148, norovirus Hu/GH-4/Ehimel/2D07/JP

27558, 3I9B8, 3B378

IDB9 VPI BAJI3B42 1099 5509 9919, 14329, 18739, 23149, narovirus Hu/GII-4/Ehimel/2008/JP

27559, 3I9B9, 3B37S

1100 VPI BAJI3B48 1100 5510 9920, 14330, 18740, 23150, norovirus Hu/Gli-4/Ehim _E 3/2007/JP

275B0.31970, 3B380

ΙΙΟΙ VPI BAJI365I HOI 5511 9921, 14331, 18741, 23151, norovirus Hu/GII-4/Ehime3/2008/JP

275BI, 31971, 3B38I

1102 VPI BAJI3654 1102 5512 3922, 14332, 18742, 23152, norovirus Hu/GII-4/Ehime4/2007/JP

275B2, 31372, 3B382

1103 VPI BAJI3657 1103 5513 3823, 14333, 18743, 23153, norovirus Hu/GII-4/Ehime4/2008/JP

275B3, 31973, 3B383

1104 VPI BAJI3GB0 1104 5514 9324, 14334. 18744, 23154, narovirus Hu/GII-4/Ehime5/2008/JP

275B4, 31374, 3B384

1105 VPI BAJI3BB3 1105 5515 3325, 14335, 18745, 23155, norovirus Hu/GII-4/Fukuil/2008/JP

275B5.31375, 3B385

HOG VPI BAJI3BBB HOB 55IB 392B, I433B, I874B, 23I5B. norovirus Hu/GII-4/Fukui2/2007/JP

275BB, 3I97B, 3B38B

1107 VPI BAJI3BBB 1107 5517 3827, 14337, 18747. 23157, norovirus Hu/GII-4/Fukui2/2008/JP

275B7, 31977, 3B387

1108 VPI BAJI3B72 1108 5518 9928, 14338, 18748, 23158, norovirus Hu/GII-4/Fukui4/2007/JP

275B8, 31378, 3B388

HOB VPI BAJI3B75 1109 5519 3923. 14333, 18749, 23159. norovirus Hu/GII-4/Fukui4/2008/JP

275B9, 31979, 3B389

1110 PI BAJI3B78 1110 5520 9930. 14340, 18750. 23IB0. narovirus Hu/GII-4/Fukui5/2007/JP

27570, 31980, 3B390

llll VPI BAJI3B8I llll 5521 9931, 14341, 18751, 23161. norovirus Hu/GII-4/Fukui5/2008/JP

27571.31981, 3B39I

1112 VPI BAJI3B84 1112 5522 9332, 14342. 18752. 23IB2, narovirus Hu/GII-4/Hiroshimal/2007/JP

27572, 31982, 36392 1113 PI BAJI3B87 1113 5523 9933. 14343. 18753, 23IB3. noPDvirus Hu/BII-4/Hirashimal/2008/JP

27573, 31983, 3B393

1114 VPI BAJI3B9B 1114 5524 9934, 14344, 18754, 23IB4, norovirus Hu/GII-4/Hiroshima2/2007/JP

27574, 31984, 3B394

1115 VPI BAJI3B93 1115 5525 9935, 14345, 18755, 23IB5, norovirus Hu/BII /Hiroshima2/2008/JP

27575, 31985, 3B395

lilG VPI BAJI3B9G 1KB 552B 9936. 14346, 18756, 23IB6, norovirus Hu/Gii-4/HiroshimaS/2007/JP

2757B, 3I98B.3B39B

1117 VPI BAJI3B99 1117 5527 9937. 14347, 18757, 23IB7, norovirus Hu/GII-4/Hiroshima3/2008/JP

27577, 31987, 3B397

HIS VPI BAJI37D2 1118 5528 9938, 14348, 18758, 23IB8, narovirus Hu/Gli-4/Hirashima4/2007/JP

27578, 31988, 3B398

1119 VPI BAJI37II 1119 5529 9939, 14349, 18759, 23IB9, norovirus Hu/GII-4/Hokkaidol/2007/JP

27579, 31989, 36309

II2D VPI BAJI37I4 1120 5530 9940, 14350. I87B0, 23170, norovirus Hu/GII-4/Hokkaidol/2008/JP

27580, 31990, 3B4B0

1121 VPI BAJI37I7 1121 5531 9941, 14351, 18761, 23171, norovirus Hu/BII-4/Hokkaido2/2007/JP

27581, 31991, 36401

1122 VPI BAJI372D 1122 5532 9942, 14352, 18762, 23172, norovirus Hu/GII-4/Hokkaido2/2D08/JP

27582, 31992, 36402

1123 VPI BAJI3723 1123 5533 9943, 14353, 18763, 23173, norovirus Hu/GII-4/Hokkaido3/2008/JP

27583, 31993, 36403

1124 VPI BAJI372B 1124 5534 9944, 14354, 18764, 23174. norovirus Hu/BII-4/Hakkaido4/2D07/JP

27584, 31994. 3B404

1125 VPI BAJI3723 1125 5535 9945, 14355, 18765, 23175, norovirus Hu/GII-4/Hokkaido4/2008/JP

27585, 31995, 36405

II2B PI BAJI3732 1126 553B 9946, 14356, I876B, 23I7B. norovirus Hu/GII-4/Hokkaido5/2007/JP

27586, 31996, 36406

1127 VPI BAJI3738 1127 5537 9947, 14357, 18767, 23177, norovirus Hu/GII-4/lwatEl/2DD8/JP

27587, 31997, 36407

1128 PI BAJI374I 1128 5538 9948, 14358, I87B8. 23178, norovirus Hu/GII-4/lwatE2/2007/JP

27588, 31998, 36408

1129 VPI BAJI3744 1129 5539 9949, 14359, 18769, 23179. norovirus Hu/GII-4/lwate3/2007/JP

27589, 31999, 36409 1130 VPf BAJI3747 1130 5540 9950. 14360. 18770, 23180. norovirus Hu/GII-4/lwate3/2008/JP

27590. 32000, 3B4I0

1131 VPI BAJI375D 1131 5541 BB5I, 14361. 18771, 23181. norovirus Hu/GII-4/lwate4/2G07/JP

27531, 32001, 3B4II

1132 VPI BAJI3753 1132 5542 9952. I43B2, 18772, 23182, norovirus Hu/GII-4/lwate4/2008/JP

27592.32002, 3B4I2

1133 VPI BAJI375B 1133 5543 9953, 14363, 18773, 23183, norovirus Hu/GII-4/lwatB5/2007/JP

27593, 32003, 3B4I3

1134 VPI BAJI375B 1134 5544 3954, I43B4, 18774, 23184, norovirus Hu/GII-4/lwatE5/2008/JP

27594. 32004.36414

1135 VPI BAJI37B2 1135 5545 9955. 14365, 18775, 23185. norovirus Hu/Gll-4/Kumamotol/2007/JP

27595, 32005, 36415

1136 VPI BAJI37B5 II3B 554B 9956. 14366, 18776, 23186, norovirus Hu/GII-4/KumamotD2/2007/JP

27596, 32006.36416

1137 VPI BAJI37B8 1137 5547 9957, 14367, 18777, 23187, norovirus Hu/GII-4/ umamota3/2007/JP

27597, 32007, 36417

1138 VPI BAJI377I 1138 5548 9958. 14368, 18778, 23188, norovirus Hu/GII-4/Kumamoto4/2007/JP

27598, 32008, 36418

1138 VPI BAJI3774 1139 5549 9959, 14369, 18779, 23189. norovirus Hu/GII-4/Miyagil/2007/JP

27599, 32009, 36419

1140 VPI BAJI3777 1140 5550 9960, 14370, 18780, 23190, norovirus Hu/GII-4/Miyagi2/2007/JP

27600, 32010, 36420

1141 VPI BAJI378D 1141 5551 9961, 14371, 18781, 23191, norovirus Hu/GII-4/Miyagi3/2007/JP

27601, 32011, 36421

1142 PI BAJI3783 1142 5552 9962, 14372, 18782, 23192, norovirus Hu/GII-4/Miyagi5/2008/JP

27602, 32012, 36422

1143 VPI BAJI378B 1143 5553 9963, 14373, 18783, 23193, norovirus Hu/GII-4/MiyazakilO/2D08/JP

27603, 32013, 36423

1144 VPI BAJI37B2 1144 5554 9964, 14374, 18784, 23194, norovirus Hu/GII-4/Miyazakil3/2D08/JP

27BB4.32014.36424

1145 VPI BAJI3735 1145 5555 33B5, 14375, 18785, 23135, norovirus Hu/GII-4/Miyazakil/2007/JP

27B05, 32015.36425

1KB VPI BAJI380I 1146 5556 9966, 14376, 18786, 23196, norovirus Hu/GII-4/ iyazaki2/2007/JP

27606, 32016, 36426 1147 VPI BAJI38Q4 1147 5557 9967, 14377. 18787, 23197, norovirus Hu/GII-4/Miyazaki2/2008/JP

27607, 32017, 36427

1148 VPI BAJI38D7 1148 5558 9968, 14378, 18788, 23108, norovirus Hu/GII-4/Miyazaki3/20D7/JP

27608, 32018, 36428

1149 PI BAJI38I0 1149 5559 9969, 14379, 18789. 23199, norovirus Hu/GII-4/Miyazaki3/2008/JP

27609, 32019, 36429

1150 VPI BAJI38IG II5D 5560 9970, 14380, 18790, 23200, norovirus Hu/GII-4/Miyazaki4/2008/JP

27610, 32020, 36430

1151 PI BAJI38I9 1151 5561 9971, 14381, 18791, 23201, norovirus Hu/GII-4/ iyazaki5/2Q07/JP

27611, 32021, 36431

1152 VPI BAJI3822 1152 5562 9972, 14382, 18792, 23202, norovirus Hu/GII-4/Miyazaki6/2008/JP

27612, 32022, 36432

1153 VPI BAJI3825 1153 5563 B973, 14383, 18793, 23203, norovirus Hu/GII-4/Miyazaki7/2008/JP

27613, 32023, 36433

1154 VPI BAJI3828 1154 5564 9974, 14384, 18794, 232D4, norovirus Hu/GII-4/Miyazaki8/2008/JP

27614, 32024.36434

1155 VPI BAJI383I 1155 5565 9075, 14385. 18795, 23205, norovirus Hu/GII-4/Miyazaki9/2008/JP

27615, 32025.36435

MSB VPI 8AJI3834 1156 5566 9976, 14386, 18796, 23206, norovirus Hu/GII-4/Naganol/20D7/JP

27BI6, 32026, 36436

1157 VPI BAJI3837 1157 5567 9977, 14387, 18797, 23207, norovirus Hu/GII-4/Naganol/2008/JP

27617, 32027, 3B437

1158 PI BAJI384D 1158 5568 9978, 14388, 18798, 23208, norovirus Hu/GII-4/Nagano2/2007/JP

27618, 32028, 36438

1159 VPI BAJI3843 1159 5569 9979, 14389, 18799, 23209, norovirus Hu/GII-4/Nagano2/2008/JP

27BIB, 32029, 36439

1160 VPI BAJI3846 1160 5570 9980, 14390, 18800, 23210, norovirus Hu/GII-4/Nagano3/2007/JP

27B20, 32030, 3B440

net VPI BAJI3849 1161 5571 9981, 14391, 18801, 23211, norovirus Hu/GII-4/Nagano3/2Q08/JP

27621, 32031, 36441

IIGZ VPI BAJI3852 1162 5572 9982, 14392, I88D2, 23212, norovirus Hu/GII-4/Nagano4/2008/JP

27622, 32032, 36442

1163 VPI BAJI3855 1163 5573 9983. 14393, 18803, 23213, norovirus Hu/GII-4/Nagano5/2D07/JP

27623, 32033, 36443 1164 VPI BAJI3858 1164 5574 9984, 14394, 18804, 23214, norovirus Hu/GII-4/Niigatal/2007/JP

27624.32034, 36444

1165 VPI BAJI386I 1165 5575 9985, 14395, 18805. 23215, narovirus Hu/GII-4/Hiigatal/20D8/JP

27625, 32035.36445

1166 VPI BAJI3864 1166 5576 9986. 14396, 18806, 23216, norovirus Hu/GII-4/Niigata2/2007/JP

27B26, 32D36, 36446

1167 VPI BAJI3867 1167 5577 9987, 14397, 18807, 23217, norovirus Hu/GII-4/Niigata2/2008/JP

27627, 32037, 36447

1168 VPI BAJI3873 1168 5578 9988, 14398, 18808, 23218, narovirus Hu/GII-4/Niigata3/2008/JP

27628, 32038, 36448

1168 VPI BAJI3876 1168 5578 9989, 14399, 18809, 23219, norovirus Hu/GII-4/Niigata4/2007/JP

27G29, 32039, 36449

1170 VPI BAJI387B 1170 5580 9990, 14400, 18810, 23220. narovirus Hu/GII-4/Niigata4/20D8/JP

27630.32040, 3B450

1171 VPI BAJI3882 1171 5581 9991, 14401. 18811 2322!, norovirus Hu/GII-4/Niigata5/2Q07/JP

27B31, 32041, 36451

1172 VPI BAJI3885 1172 5582 9992. 14402, 18812, 23222, narovirus Hu/GII-4/Niigata5/2008/JP

27632, 32042, 36452

1173 VPI BAJI389I 1173 5583 9993, 14403, 18813, 23223, norovirus Hu/GII-4/0sakal/2008/JP

27633, 32043, 36453

1174 VPI BAJI3894 1174 5584 9994, 14404, 18814, 23224, norovirus Hu/GII-4/0saka2/2007/JP

27634, 32044, 36454

1175 VPI BAJI3897 1175 5585 9995, 14405, 18815, 23225, norovirus Hu/GII-4/0saka2/2008/JP

27635, 32045, 36455

1176 VPI BAJI3900 1176 5586 999B, 14406, 18816, 23226, norovirus Hu/GII-4/0saka3/2007/JP

27B3B, 32046, 36456

1177 VPI BAJI3903 1177 5587 9997, 14407, 18817, 23227. narovirus Hu/GII-4/Dsaka3/2008/JP

27637, 32047, 36457

1178 VPI BAJI3B06 1178 5588 9998, 14408, 18818, 23228, narovirus Hu/GII-4/0saka4/2007/JP

27638, 32048, 36458

1178 VPI BAJI390B 1173 5589 9999, 14409, 18819, 23229, narovirus Hu/GII-4/0saka4/2008/JP

27639, 32049, 3B459

1180 VPI BAJI39I2 1180 5590 10000, 14410, 18820, 23230, narovirus Hu/GII-4/Dsaka5/2007/JP

27640, 32050, 364B0 1181 VPI 8AJI39I8 1181 5591 10001, 14411. 18821. 23231, norovirus Hu/GII-4/0saka6/2008/JP

27641. 32051, 36461

1182 VPI BAJI3924 1182 5592 ID002. 14412, 18822, 23232, norovirus Hu/GII-4/Sagal/2008/JP

27B42, 32052, 364B2

1183 VPI BAJI3927 1183 5593 10003. 14413, 18823, 23233, narovirus Hu/GII-4/Saga2/2007/JP

27643, 32053, 36463

1184 VPI BAJI393D 1184 5594 I00D4, 14414, 18824, 23234, norovirus Hu/GII-4/Saga2/2008/JP

27644, 32054, 36464

1185 VPI BAJI3933 1185 5595 10005, 14415, 18825, 23235, narovirus Hu/GII-4/Saga3/2008/JP

27645, 32055, 36465

1186 VPI BAJI3936 1186 559B I000B, 14416. 18826, 23236, nnrovirus Hu/GII-4/Saga4/2007/JP

27646, 32056, 36466

1187 VPI BAJI3939 1187 5597 10007, 14417, 18827, 23237, narovirus Hu/GII-4/Saga4/2008/JP

27647, 32057, 36467

1188 VPI BAJI3942 1188 5598 10008, 14418, 18828, 23238, norovirus Hu/GII-4/Saga5/2007/JP

27648, 32058, 36468

1188 VPI BAJI3945 1189 5599 10009, 14419, 18829, 23239, norovirus Hu/GII-4/Saga5/2008/JP

27649, 32059, 36469

1180 VPI BAJI3948 1190 5B00 IDDIO, 14420, 18830, 23240, norovirus Hu/GII-4/Sakail/2007/JP

27B50, 320B0, 36470

1191 VPI BAJI395I 1191 5601 tOOII, 14421, 18831, 23241. norovirus Hu/GII-4/Sakail/2008/JP

27B51, 32061. 36471

1192 VPI BAJI3954 1192 5602 10012. 14422, 18832, 23242, norovirus Hu/GII-4/Sakai2/2007/JP

27652, 32062, 36472

1193 VPI BAJI3957 1193 5603 10013, 14423, 18833, 23243, norovirus Hu/GII-4/Sakai3/2007/JP

27653, 320B3, 36473

1194 VPI BAJI396D 1194 5604 10014, 14424, 18834, 23244, norovirus Hu/GII-4/Sakai3/20Q8/JP

27654, 32064, 36474

1195 VPI BAJI39B3 1195 5605 10015, 14425. 18835, 23245, norovirus Hu/GII-4/Sakai4/2007/JP

27655, 32065, 36475

1196 VPI 6AJI3966 1196 560B ID0I6, 14426, 18836, 23246, norovirus Hu/GII-4/Sakai4/2008/JP

27656, 32066, 36476

1197 VPI BAJI39B9 1197 5607 10017, 14427. 18837, 23247, norovirus Hu/Gil-4/Shimanef/2007/JP

27657, 32067, 36477 lias VPI BAJI3972 1198 5B08 10018. 14428. 18838, 23248, norovirus Hu/GII-4/Shimane2/2007/JP

27B58, 320B8.3B478

nee VPI BAJI3975 1190 5B09 10019. 14429, 18839. 23249, norovirus Hu/GII-4/Shimane2/2D08/JP

27B59, 320B9, 36479

I2DQ VPI BAJI3978 1200 5BI0 10020, 14430, 18840, 23250, norovirus Hu/GII-4/ShimanE3/2007/JP

27B60, 32070, 36480

I2DI VPI BAJI398I I2DI 5BII ID02I. 14431, 18841, 23251, norovirus Hu/GII-4/Shimane3/2008/JP

27BBI, 32071, 36481

I2D2 VPI BAJI3984 1202 5BI2 10022, 14432, 18842, 23252, norovirus Hu/GII-4/Shiman_4/2007/JP

27662, 32072, 3B482

1203 VPI BAJI3987 1203 5BI3 10023, 14433, 18843, 23253, norovirus Hu/GII-4/ShimanB5/2007/JP

27663, 32073.36483

I2D4 VPI BAJI3990 1204 5BI4 10024. 14434, 18844, 23254, norovirus Hu/GII-4/ShimanB5/2008/JP

27664, 32074, 36484

1205 VPI BAJI3993 1205 5BI5 10025, 14435, 18845, 23255, norovirus Hu/GII-4/Toyamal/2007/JP

276B5, 32075, 36485

I20B VPI BAJI399B I20B 5BIB 10026, 14436, 18846, 23256, norovirus Hu/GII-4/Toyama2/2007/JP

27BBB, 32076, 3G486

1207 VPI BAJI3999 I2D7 5BI7 10027, 14437, 18847, 23257, norovirus Hu/GII-4/Toyama2/2008/JP

27667, 32077, 36487

1208 VPI BAJI4002 I2D8 5BI8 10028, 14438. 18848. 23258, norovirus Hu/GII-4/Toyama3/2007/JP

276B8, 32078, 3B488

1209 VPI BAJI4005 1209 5BI9 10029, 14439, 18849. 23259. norovirus Hu/GII-4/Toyama3/2008/JP

27669, 32079, 36489

1210 VPI BAJI4008 1210 5B20 I003D, 14440, 18850, 23260, norovirus Hu/GII-4/Toyama4/2007/JP

27B70, 32080, 36490

1211 PI BAJI40II 1211 5621 10031, 14441, 18851, 232BI, norovirus Hu/GII-4/Toyama4/2008/JP

27B71, 32081, 36491

1212 PI BAJI40I4 1212 5B22 10032, 14442, 18852, 232B2, norovirus Hu/GII-4/Toyama5/2007/JP

27672, 32082, 36492

1213 VPI BA 432B9 1213 5B23 10033, 14443, 18853, 23263, norovirus Hu/Tokyo/I0-I4/20IO/JPN

27B73, 32083, 36493

1214 VPI BAK43272 1214 5B24 10034, 14444, 18854, 23264, norovirus Hu/Tokyo/IO-20/2010/JPN

27674, 32084, 36494 1215 VPI BAK43275 1215 5B25 10035, 14445, 18855, 232B5, norovirus Hu/Tokyo/I0-H05/20IO/JPN

27B75, 32085, 3B495

1216 VPI BAK43278 I2IB 5G2B I0D3B, I444B, I885B, 232BB, norovirus Hu/Tokyo/IO-1443/2010/JPN

27B7B, 32B8B, 3B49B

1217 VPI BA 43284 1217 5B27 10037, 14447, 18857, 232B7, norovirus Hu/Tokyo/I0-4320/20II/JPN

27B77, 32087, 3B497

1218 VPI BALI4785 1218 5B28 I0D38, 14448, 18858, 232B8, norovirus Hu/GII hime09037l/20DB/JP

27B78, 32088.3B498

I2IB VPI BA 88I57 1219 5B29 10039, 14449, 18859, 232B9, norovirus GVI.I/Ca/JPN/2DI2/M49-l

27B79, 32089, 3B499

I22D VPI BAS29993 1220 5B3B IBB40, 14450, 188B0, 23270, norovirus Hu/GII.4/Toyamal/2009/JP

27B80, 32090, 3B500

1221 VPI BAS2999G 1221 5B31 10041, 14451, 18861. 23271, norovirus Hu/GII.4/Toyama4/20D9/JP

27B81, 320BI, 3B50I

1222 VPI BAS29999 1222 5B32 IDD42, 14452, 18862, 23272, norovirus Hu/GII.4/ShimanBl/2009/JP

27B82, 32092, 3B502

1223 VPI BAS30005 1223 5B33 10043, 14453, 18863, 23273. norovirus Hu/GII.4/Aomnri2/2009/JP

27683, 32093, 3B503

1224 VPI BAS30008 1224 5B34 I0D44, 14454, 18864, 23274, norovirus Hu/GII.4/Hiroshimacity3/2D09/JP

27684.32094, 36504

1225 VPI BAS300II 1225 5B35 10045, 14455, 18865, 23275, norovirus Hu/GII.4/HiroshimBcity4/2009/JP

27685, 32095, 36505

I22B VPI BAS300I4 I22B 5B3B 10046, 14456, I88BB, 23276, norovirus Hu/GII.4/Hiroshimacity5/2009/JP

27686.32096.36506

1227 VPI BAS3D0I7 1227 5B37 10047, 14457, 18867, 23277, norovirus Hu/GII.4/lwate2/2DD9/JP

27687, 32097, 3B507

1228 VPI BAS30023 1228 5B38 10048, 14458, 18868, 23278, norovirus Hu/GII.4/Aichi4/2009/JP

27688, 32098, 36508

1229 VPI 8AS3002G I22B 5B39 10049, 14459, 18869, 23279, norovirus Hu/GII.4/Shimane2/2009/JP

27689, 32099, 36509

1230 VPI BAS30029 I23D 5B40 10050, 144B0, 18870, 23280, norovirus Hu/GII.4/Miyazakil/2009/JP

27690, 32100, 36510

1231 VPI BAS30D35 1231 5B4I 10051, 14461, 18871, 23281, norovirus Hu/GII.4/Aomori4/2QI0/JP

27691, 32101, 36511 1232 VPI BAS3DD38 1232 5B42 IGB52, I44B2, 18872, 23282, norovirus Hu/GII.4/lwate5/20IO/JP

27692, 32IB2, 3B5I2

1233 VPI BAS3004I 1233 5B43 I0D53, I44B3, 18873, 23283, norovirus Hu/GII.4/Toyama5/20IO/JP

27B93, 32IB3, 3B5I3

1234 VPI BAS3DD44 1234 5B44 10054, I44B4, 18874, 23284, norovirus Hu/GII.4/Chibal/20IO/JP

27B94, 32104, 3B5I4

1235 VPI BAS3DB47 1235 5B45 ID055, I44B5, 18875, 23285, norovirus Hu/GII.4/Chiba3/ZDID/JP

27B95, 32105, 3B5I5

1236 VPI BAS3BB5D I23G 5B4B I005B, I44BB, I887B, 2328B, norovirus Hu/GII.4/Chiba5/20IO/JP

27BBB, 32106.365IB

1237 VPI BAS3QD53 1237 5B47 10057, 14467, 18877, 23287, norovirus Hu/GII.4/Naganol/20IO/JP

27B97, 32107, 3B5I7

1238 VPI BAS30056 1238 5G48 10058, 144B8, 18878, 23288, norovirus Hu/GII.4/Aichi5/20IO/JP

27B98, 32108, 3B5I8

1239 VPI BAS3DD59 1239 5B49 I0D59, 14469, 18879, 23289, norovirus Hu/GII.4/Osaka2/20IO/JP

27B99, 32109, 36519

I24D VPI BAS3DDB2 I24D 5B5D IOOGO, 14470, 18880, 23290, norovirus Hu/GII.4/Osaka3/20IO/JP

27700, 32110, 36520

1241 VPI BAS3DDB5 1241 5B5I 10061. 14471. 18881. 23291, norovirus Hu/GII.4/Osaka4/20IO/JP

27701, 32111. 3B52I

1242 VPI BAS3DBG8 1242 5B52 10062. 14472, 18882, 23292, norovirus Hu/GII.4/Sakail/20IO/JP

27702, 32112, 36522

1243 VPI BAS3BB7I 1243 5B53 10063, 14473, 18883, 23293, norovirus Hu/GII.4/Sakai2/20IO/JP

27703, 32113, 36523

1244 VPI BAS3DB74 1244 5B54 10064. 14474, 18884, 23294, norovirus Hu/GII.4/Hiroshima3/20IQ/JP

27704, 32114, 3B524

1245 VPI BAS3DB77 1245 5B55 10065, 14475, 18885, 23295, norovirus Hu/GII.4/Hiroshima4/20IO/JP

27705, 32115, 36525

I24B VPI BAS3BD8D I24B 5B5B IOOBB, 14476, 18886, 23296, norovirus Hu/Bli.4/Miyazaki2/2Df D/JP

27706, 32116, 36526

1247 VPI BAS3BD83 1247 5B57 I00B7, 14477, 18887, 23297, norovirus Hu/GII.4/Miyazaki3/20IO/JP

27707, 32117, 36527

1248 VPI BAS30086 1248 5B58 10068, 14478, 18888, 23298. norovirus Hu/GII.4/Hokkaido4/20IO/JP

27708, 32118, 3B528 1249 VPI BAS30089 1249 5B59 ID0B9, 14479, 18889. 23299. norovirus Hu/GII.4/NiigataZ/ZOIO/JP

27709, 32119.36529

1250 VPI BAS30QB2 1250 5BB0 10070, 14480, 18890, 23300, narovirus Hu/GII.4/Niigata3/20IO/JP

27710, 32I2D, 3B530

1251 VPI BAS30D95 1251 5BBI 10071, 14481, 18891, 23301, norovirus Hu/GII.4/Niigata4/20IO/JP

27711, 32121, 3B53I

1252 VPI BAS30098 1252 5BB2 10072, 14482, 18892, 23302, norovirus Hu/GII.4/Fukui2/20IO/JP

27712, 32122, 3B532

1253 VPI BAS3DI0I 1253 5BB3 10073, 14483, 18893, 23303, norovirus Hu/GII.4/Fukui3/20IO/JP

27713, 32123, 3B533

1254 VPI BAS3DI04 1254 5BB4 10074, 14484, 18804, 23304, norovirus Hu/GII.4/Fukui4/20IO/JP

27714, 32124, 3B534

1255 VPI BAS3DID7 1255 5BB5 10075, 14485, 18895, 23305, norovirus Hu/GII.4/Nagano3/20IO/JP

27715, 32125, 3B535

I25B VPI BAS30IID I25B 5BBB I007B, I448B, 18896. 2330B, norovirus Hu/GII,4/Sakai3/20IO/JP

27716, 32126, 36536

1257 VPI BAS3DII3 1257 5BB7 10077, 14487, 18897, 23307, norovirus Hu/GII.4/Sakai4/20ID/JP

27717, 32127, 36537

1258 VPI BAS3DIIB 1258 5BB8 10078, 14488, 18808, 23308, norovirus Hu/GII.4/Ehime3/20IO/JP

27718, 32128, 36538

1259 VPI BAS30II9 1259 5BB9 10079, 14489, 18899, 23309, norovirus Hu/GII.4/Ehime5/20IO/JP

27719, 32129, 36539

I2BD VPI BAS3DI25 I2G0 5B70 10080, 14490, I890D, 23310, norovirus Hu/GII.4/Shiman_5/20ID/JP

27720, 32130, 36540

I2BI VPI BAS30I28 I2BI 5B7I 10081, 14491, 18901, 23311, norovirus Hu/GII.4/Saga5/20IO/JP

27721, 32131, 36541

I2B2 VPI BAS3DI34 I2B2 5B72 10082, 14492, 18902, 23312, norovirus Hu/GII.4/Miyazaki5/20IO/JP

27722, 32132, 36542

I2B3 VPI BAS3DI37 I2B3 5B73 10083, 14493, I89D3, 23313, norovirus Hu/GII.4/Nagano5/20ll/JP

27723, 32133, 36543

I2B4 VPI BAS30I40 I2B4 5B74 10084, 14494, 18904, 23314, norovirus Hu/GII.4/Sakai7 2DII/JP

27724, 32134, 36544

I2B5 VPI BAS30I4B I2B5 5B75 10085, 14495, 18905, 23315, norovirus Hu/GII.4/SakailO/20ll/JP

27725, 32135, 36545 1266 VPI 8AS30I49 I2BB 5676 10086, I449G, 18906, 23316, noravirus Hu/GII.4/Shimanel/20ll/JP

27726, 32I3B, 36546

1267 VPI BAS30I52 1267 5677 ID087, 14497, 18907, 23317, noravirus Hu/GII.4/Shimane2/20ll/JP

27727, 32137, 36547

1268 VPI BAS3DI55 1268 5678 10088, 14498, 18908, 23318, noravirus Hu/GII.4/Hirnshimacity2/20ll/ JP

27728, 32138, 36548

I26B VPI BAS30I58 1269 5679 10089, 14499, 18909, 23319, noravirus Hu/GII.4/Akita2/20ll/JP

27729, 32139, 3B549

I27D VPI BAS30I64 I27D 568D I009D, 14500, 18910, 23320, norovirus Hu/Gi!.4/AkitB3/2DI1/JP

27730, 32140, 36550

1271 VPI BAS3DI67 1271 5681 10091, 14501, 18911. 23321, noravirus Hu/GII.4/0saka3/2DII/JP

27731, 32141, 36551

1272 VPI BAS30I70 1272 5682 10092, 14502, 18912, 23322, norovirus Hu/GII.4/Shimane4/20ll/JP

27732, 32142, 36552

1273 VPI BAS3DI73 1273 5683 10093, I45D3, 18913, 23323, norovirus Hu/GII.4/Ehime!/20ll/JP

27733, 32143, 36553

1274 VPI BAS3DI76 1274 5684 10094, 14504, 18914, 23324, norovirus Hu/GII.4/Ehime2/20ll/JP

27734, 32144, 3B554

1275 VPI BAS3DI79 1275 5685 10095, 14505, 18915, 23325, norovirus Hu/GII.4/Sagal/2DII/JP

27735, 32145, 36555

1276 VPI BAS30I82 1276 5686 10096, 14506, 18916, 23326, norovirus Hu/GII.4/Saga2/20ll/JP

27736, 32146.36556

1277 VPI BAS3DI85 1277 5687 10097, I45D7, 18917, 23327, norovirus Hu/GII.4/Hiroshimacity3/20ll/JP

27737, 32147, 36557

1278 VPI BAS30I88 1278 5688 10098, 14508, 18918, 23328, norovirus Hu/GII.4/Hokkaidol/2DII/JP

27738, 32148, 36558

1279 VPI BAS3DI9I 1279 5689 10099, 14509, 18919, 23329, norovirus Hu/GII.4/Aomori4/20ll/JP

27739, 32149, 36559

1280 VPI BAS3DI94 1280 5690 10100, 14510, I892D, 23330, noroviros Hu/GII.4/Aomori5/20tl/JP

27740, 32150, 36560

1281 VPI BAS3DI97 1281 5691 tOtOI. 14511, 18921, 23331, norovirus Hu/GII.4/Aomori6/20ll/JP

27741, 32151, 365BI

1282 VPI BAS3Q20D 1282 56B2 10102, 14512, 18922, 23332, norovirus Hu/GII.4/Aomori7/20ll/JP

27742, 32152, 36562 1283 VPI BAS3D2D3 1283 5693 10103. 14513, 18923, 23333, norovirus Hu/GII.4/lwate2/20ll/JP

27743, 32153, 3B563

1284 VPI BAS302D6 1284 5G94 10104, 14514, I8B24, 23334, norovirus Hu/GII.4/lwate4/20ll/JP

27744, 32154, 36564

1285 VPI BAS3D209 1285 5B95 10105, 14515, 18925, 23335, norovirus Hu/GII.4/lw3te5/20tl/JP

27745, 32155, 36565

1286 VPI BAS3D2I2 I28B 5696 10106, 14516, 18926, 23336, norovirus Hu/GII.4/Toyama5/20ll/JP

27746, 32156, 36566

1287 VPI BAS3B2I5 1287 5B97 10107, 14517, 18927, 23337. norovirus Hu/GII.4/Aichil/20ll/JP

27747, 32157, 36567

1288 VPI BAS3B2I8 1288 5698 10108, 14518, 18928, 23338, narovirus Hu/GII.4/Hiroshimal/20fl/ JP

27748, 32158.365B8

1289 VPI BAS3022I 1289 5699 10109, 14519, 18929, 23339. norovirus Hu/GII.4/Hiroshima2/20ll/JP

27749, 32159, 365B9

I29D VPI BAS30224 1200 57DD 10110. 14520, I893D, 23340, norovirus Hu/GII.4/Hiroshima4/20ll/JP

27750.32160, 36570

1291 VPI BAS30227 1291 5701 IOIII, 14521, 18931. 23341. norovirus Hu/GII.4/Ehime3/20ll/JP

27751, 32161, 36571

1292 VPI BAS3B23B 1292 5702 10112, 14522, 18932, 23342, norovirus Hu/GII.4/Saga3/2DII/JP

27752.32162.3B572

1293 VPI BAS30233 1293 5703 10113. 14523. 18933, 23343, narovirus Hu/GII.4/Aichi3/20ll/JP

27753, 32IB3, 36573

1294 VPI BAS3D23B 1294 57D4 IDI14, 14524. 18934, 23344, narovirus Hu/GII.4/ShimaneG/ZDII/JP

27754, 32IB4, 3B574

1295 VPI BAS30239 1295 5705 10115, 14525, 18935, 23345, norovirus Hu/GII.4/Ehime4/20ll/JP

27755, 32165, 36575

1296 VPI BAS30242 1296 5706 10116, 14526, 18936. 2334B, norovirus Hu/BII.4/ChibalO/ZDII/JP

27756, 32IB6, 36576

1297 VPI BAS30245 1297 5707 10117, 14527, 18937, 23347, norovirus Hu/GII.4/Akita5/2009/JP

27757.32IB7, 36577

1298 VPI BAS30248 1298 5708 10118, 14528, 18938, 23348, norovirus Hu/GII.4/Fukui5/2009/JP

27758, 32168, 36578

1299 VPI BAS3025I 1299 5709 10119, 14529, 18939, 23349, norovirus Hu/GII.4/Ehimel/2B09/JP

27759, 32IG9, 36579 1300 VPI BAS30254 1300 5710 10120. 14530. 18940, 23350, norovirus Hu/GII.4/Hokkaidol/2009/JP

277B0, 32170.36580

1301 VPI BAS30257 1301 5711 10121, 14531. 18941, 23351, norovirus Hu/GII.4/Hokkaido2/20D9/JP

27761, 32171, 36581

1302 VPI BAS30260 1302 5712 10122, 14532, 18942, 23352, norovirus Hu/GII.4/Hokkaido5/200B/JP

277B2, 32172, 3B582

1303 VPI BAS302B3 1303 5713 10123, 14533, 18943, 23353. norovirus Hu/GII.4/Aomori5/2009/JP

277B3, 32173, 36583

1304 VPI BAS302BB 1304 5714 10124, 14534. 18944. 23354, norovirus Hu/GII.4/lwate4/2009/JP

27764, 32174, 3B584

1305 VPI BAS302B9 1305 5715 10125, 14535, I8B45, 23355, norovirus Hu/GII.4/Aichi2/2D09/JP

27765, 32175, 36585

1306 VPI BAS30272 I30B 57IB 10126. 14536, 18946, 23356, norovirus Hu/GII.4/Aichi3/2009/JP

27766, 32I7B.36586

1307 VPI BAS30275 1307 5717 10127, 14537, 18947, 23357, norovirus Hu/GII.4/Niigata5/2009/JP

27767, 32177, 36587

1308 VPI BAS30278 I30B 5718 10128, 14538, 18948, 23358, norovirus Hu/GII.4/Fukuil/2009/JP

27768, 32178, 36588

1309 VPI BAS30284 1309 5719 IDI29, 14539, 18949, 23359, norovirus Hu/GII.4/Chiba4/200B/JP

27769, 32179, 36589

1310 VPI BAS30287 1310 5720 10130, 14540, 18950, 2336D, norovirus Hu/GII.4/Nagano2/2009/JP

27770, 32180, 3B590

1311 VPI BAS3D290 1311 5721 10131. 14541, 18951, 23361, norovirus Hu/GII.4/Nagano4/2009/JP

27771. 32181, 36591

1312 VPI BAS30293 1312 5722 10132, 14542, 18952, 23362, norovirus Hu/GII.4/Nagano5/2009/JP

27772, 32182, 36592

1313 VPI BAS3029B 1313 5723 10133, 14543, 18953, 23363, norovirus Hu/GII.4/Aichi3/20IO/JP

27773, 32183, 3B593

1314 VPI BAS30299 1314 5724 10134, 14544, 18954, 23364, norovirus Hu/GII.4/Osakal/2009/JP

27774.32184, 3B594

1315 VPI BAS30302 1315 5725 10135, 14545, 18955, 233B5, norovirus Hu/GII.4/0saka5/2009/JP

27775, 32185, 3B595

1316 VPI BAS3B305 1316 572B 10136, 14546, I895B, 23366, norovirus Hu/GII.4/Ehime5/20ll/JP

2777B, 32I8B, 36596 1317 VP! BAS30308 1317 5727 10137. 14547. 18957, 23367, norovirus Hu/GII.4/Sakai5/2009/JP

27777, 32187, 36597

1318 VPI BAS3D3II 1318 5728 10138, 14548, 18958, 23368, noravirus Hu/GII.4/Hiroshimal/2009/JP

27778, 32188, 36598

1319 VPI BAS303I4 1319 5729 10139, 14549, 18959, 23369, norovirus Hu/GII.4/Hirnshima5/2009/JP

27779, 32189, 36599

I32D VPI BAS3B3I7 I32D 573B 10140, 14550, 18960, 23370, norovirus Hu/GII.4/Ehime2/20D9/JP

27780, 32190, 36600

1321 VPI BAS3D320 1321 5731 10141, 14551, 18961, 23371, norovirus Hu/GII.4/Ehime4/2009/JP

27781, 32191, 3B6DI

1322 VPI BAS3D323 1322 5732 10142, 14552, 18962, 23372, norovirus Hu/GII.4/Sagal/2009/JP

27782, 32192, 36602

1323 PI BAS3D32B 1323 5733 10143, 14553, 18963, 23373, norovirus Hu/GII.4/Saga2/2009/JP

27783, 32193, 36603

1324 VPI BAS3D329 1324 5734 10144, 14554, 18964, 23374, norovirus Hu/GII.4/Saga3/2009/JP

27784, 32194, 3B6D4

1325 PI BAS3D332 1325 5735 10145, 14555, 18965, 23375, norovirus Hu/GII.4/Saga4/2009/JP

27785, 32195, 36605

1326 VPI BAS3D335 I32B 573B 10146. 14556, 18966, 23376, norovirus Hu/GII.4/Chiba6/20ll/JP

27786, 32196, 36606

1327 VPI BAS3B338 1327 5737 10147, 14557, 18967, 23377. norovirus Hu/GII.4/Nagano26/20ll/JP

27787, 32197, 366D7

1328 VPI BAS3B34I 1328 5738 10148, 14558, 18968, 23378, norovirus Hu/GII.4/Hirashima5/20ll/JP

27788, 32198.36608

1329 VPI BAS3D344 1329 5739 10149. 14559, 18969, 23379, norovirus Hu/GII,4/0saka4/20ll/JP

27789, 32199, 36609

I33D VPI BAS3B347 I33B 574B 10150, 14560, 18970, 23380, noravirus Hu/GII.4/Hokkaido4/20ll/JP

27790, 32200, 36610

1331 VPI BAS3B35B 1331 5741 10151, 14561, 18971, 23381, norovirus Hu/GII.4/0saka2/20ll/JP

27791, 32201, 36611

1332 VP! BAS3D353 1332 5742 10152, 14562, 18972, 23382, norovirus Hu/GII.4/0saka!/20ll/JP

27792, 32202, 36612

1333 VP! BAS3B35B 1333 5743 10153, 14563, 18973, 23383, norovirus Hu/GII.4/Aichi5/20ll/JP

27793, 32203.36BI3 1334 VPI BAS30359 1334 5744 10154, I45B4. 18974, 23384, norovirus Hu/GII.4/Aichi4/20ll/JP

27704, 32204, 3BBI4

1335 VPI BAS303B2 1335 5745 10155, I45B5. 18975, 23385, nnravirus Hu/GII.4/Hokkaido3/20ll/JP

27795, 32205, 3BBI5

I33B VPI BAS303B5 I33B 574B 10156. I45BB, I897B. 2338B. noravirus Hu/GII.4/Nagano7/2DII/JP

2779B, 3220B, 3BBIB

1337 VPI BAS303B8 1337 5747 10157, I45B7, 18977, 23387, norovirus Hu/GII.4/Nagano4/20ll/JP

27797, 32207, 3BBI7

1338 VPI BAS3D37I 1338 5748 10158, I45B8, 18978, 23388, norovirus Hu/BII.4/Niigata3 20li/JP

27798, 32208, 3BBI8

1339 VPI BAS30374 1339 5749 10159, I45B9. 18979, 23389, norovirus Hu/GII.4/Hiroshimacityl/20ll/JP

27799, 322D9, 3BBI9

I34D VPI BAUIB297 1340 5750 IOIBO, 14570. 18980, 23390, norovirus GII/Hu/Jp/20l2/GII.4/sl20l53

27800, 32210, 3BB20

1341 VPI BAUIB299 1341 5751 10161. 14571. 18981, 23391, norovirus GII/Hu/Jp/20l5/GII.I7/MIY2

27801, 32211, 3BB2I

1342 VPI BAUIB3DI 1342 5752 10162. 14572, 18982, 23392. norovirus GI/Hu/Jp/20l3/GI.4/sl30l49

27802, 32212. 3B622

1343 PI BAUIB303 1343 5753 10163, 14573, 18983, 23393, norovirus GI/Hu/Jp/20l3/GI.B/sl30l47

27803, 32213. 3BB23

1344 VPI BAUIB305 1344 5754 10164. 14574, 18984, 23394. norovirus GII/Hu/Jp/2007/GII.3/Kodl

27804, 32214, 3BB24

1345 VPI BAUIB30B 1345 5755 10165, 14575, 18985, 23395, norovirus GIV/Hu/Jp/200l/GIV.I/OCOIOI7023

27805, 32215. 36625

I34B VPI BAUIB307 I34B 575B 10166, 14576, I898B, 2339B, norovirus GI/Hu/Jp/2002/GI.5/OC020l80

27806, 32216, 36626

1347 VPI BAU2483I 1347 5757 10167, 14577, 18987, 23397, norovirus Hu/GII.4/Hokkaido4/2DI2/JP

27807, 32217, 36627

1348 VPI BAU24834 1348 5758 10168, 14578, 18988, 23398, norovirus Hu/GII.4/Aomori2/20l2/JP

27808. 32218, 36628

1349 VPI BAU24837 1349 5759 10169, 14579, 18989, 23399, norovirus Hu/GII.4/Aomori3/20l2/JP

2780B, 32219, 36629

1350 VP! BAU2484D 1350 57B0 10170, 14580, 18990, 23400. norovirus Hu/GII.4/Aomori5/20l2/JP

27810, 32220, 36630 1351 VPI BAU24843 1351 5761 10171. 14581. 18931. 23401, norovirus Hu/GII.4/Akita4/20l2/JP

27811, 32221, 36631

1352 VPI BAU24846 1352 5762 10172. 14582. 18992, 23402, norovirus Hu/GII.4/Akita5/20l2/JP

27812.32222, 36632

1353 VPI BAU24849 1353 5763 10173, 14583. 18993, 23403, norovirus Hu/GII.4/lwate4/20l2/JP

27813, 32223.36633

1354 VPI BAU24852 1354 5764 10174, 14584, 18994, 23404. norovirus Hu/GII.4/lwate5/20l2/JP

27814.32224, 36634

1355 VPI BAU24855 1355 57G5 10175, 14585, 18995, 23405, norovirus Hu/GII.4/Miyagi3/2DI2/JP

27815, 32225, 36635

I35G VPI BAU24858 I35B 5766 10176, 14586, I8B96, 23406. norovirus Hu/GII.4/SaitamaZ/20l2/JP

27816.32226, 36636

1357 VPI BAU2486I 1357 5767 10177. 14587, 18937, 23407, norovirus Hu/GII.4/Toyama2/20l2/JP

27817, 32227, 36637

1358 VPI BAU248B4 1358 5768 10178, 14588, 18398, 23408. norovirus Hu/GII.4/Niigata4/20l2/JP

27818.32228, 36638

1359 VPI BAU248B7 I35B 576B 10179, 14589, 18999, 23409, norovirus Hu/GII.4/Fukui3/20IZ/JP

27819, 32229, 36639

I3GD VPI BAU2487D 1360 5770 10180, 14590, 19000, 23410, norovirus Hu/GII.4/Fukui4/20l2/JP

27820, 32230.36640

I3GI VPI BAU24873 I3GI 5771 10181. 14591, 19001, 23411, norovirus Hu/GII.4/Fukui6/2DI2/JP

27821, 32231, 36641

I3G2 VPI BAU2487B 1362 5772 10182, 14592, 19002. 23412, norovirus Hu/GII.4/Fukui7/20l2/JP

27822, 32232, 36642

1363 VPI BAU2487B 1363 5773 10183, 14593, 19003, 23413, norovirus Hu/GII.4/Fukui8/20l2/JP

27823, 32233, 36643

1364 PI BAU24882 I3G4 5774 10184. 14594, 19004, 23414, norovirus Hu/GII.4/Ehim _E 5/20l2/JP

27824, 32234, 36644

1365 VPI BAU24885 I3G5 5775 10185, 14595, 13005, 23415, norovirus Hu/GII.4/0sakaCityl/20l2/JP

27825, 32235, 36645

1366 VPI BAU24888 I36G 5776 10186, 14536, I30D6, 23416, norovirus Hu/GII.4/0sakaCity2/2DI2/JP

27826, 32236.36646

1367 VPI BAU2489I I3G7 5777 10187, 14597, 19007, 23417, norovirus Hu/GII.4/0sakaCity4/2OI2/JP

27827, 32237, 3B647 I3B8 VPI BAU24894 I3B8 5778 I0I88, I4598, I9DD8. 234I8, narovirus Hu/GII.4/Sakail/20l2/JP

27828, 32238.3BB48

I3B9 VPI BAU24897 I3B9 5779 IDI89. I4599, I9DD9, 234I9. norovirus Hu/GII.4/SakaiZ/ZDI2/JP

27829, 32239, 3BB49

I37D VPI BAU249DD I37D 578D IDI9D, I4BDD, I90ID, 2342D, norovirus Hu/GII.4/Sakai3/20l2/JP

27830, 32240, 3BB5B

I37I VPI BAU249D3 I37I 578I IDI9I, I4B0I, I90II, 2342I, norovirus Hu/GII.4/Sakai4/20l2/JP

27831, 32241, 36B5I

I37Z PI BAU249DB I372 5782 I0I92, I4B02, 19012. 23422, norovirus Hu/GII.4/Sakai5/20IZ/JP

27832, 32242.3BB52

I373 VPI BAU249D9 I373 5783 10193, I4B03. 19013, 23423, norovirus Hu/GII.4/Shimane3/2DI2/JP

27833, 32243, 3GB53

I374 VPI BAU249I2 I374 5784 10194, I4G04, 19014, 23424, norovirus Hu/GII.4/Shimane5/ZDIZ/JP

27834, 32244, 3BB54

I375 VPI BAU249I5 I375 5785 10195, I4B05, 19015, 23425, norovirus Hu/GII.4/Hiroshima4/20l2/JP

27835, 32245, 3GB55

I37B VPI BAU249I8 I37B 578B I0I9B. I4B0B, 19016. 2342B, norovirus Hu/GII.4/Hiroshima5/20l2/JP

27830, 32246, 36656

I377 VPI BAU2492I I377 5787 10197, I4B07, 19017, 23427, norovirus Hu/GII.4/HiroshimaCity3/20l2/JP

27837, 32247, 3BB57

I378 VPI BAU24924 I378 5788 10198, I4B08, 19018, 23428, norovirus Hu/GII.4/HiroshimaCity4/20l2/JP

27838, 32248. 3BB58

I379 VPI BAU24927 I379 5789 10199, 14609, 19019, 23429, norovirus Hu/GII.4/Ehime3/20l2/JP

27839, 32249. 36G59

I380 VPI BAU2493D I38D 579D 10200, 14610. 19020. 23430, norovirus Hu/GII.4/GII4-HK0l/20ll/JP

27840, 32250, 3GG60

I38I VPI BAU24933 I38I 579I 10201, 14611, I90ZI. 23431, norovirus Hu/GII.4/GII4-H 02/20ll/JP

27841, 32251, 36G6I

I382 VPI BAU2493G I382 5792 10202, 14612. 19022. 23432. norovirus Hu/GII.4/GII4-HK03/20ll/JP

27842. 32252, 36662

I383 VPI BAU24942 I383 5793 I02D3, 14613, 19023, 23433, norovirus Hu/GII.4/GII4-NGI3l5/20ll/JP

27843, 32253, 36B63

I384 VPI BAU24945 I384 5794 10204. 14614. 19024. 23434, norovirus Hu/GII.4/GII4-NGI343/2DII/JP

27844. 32254, 36664 1385 VPI BAU24948 1385 5795 10205, 14615, 19025, 23435, naravirus Hu/GII.4/GII4-NGI3B5/ZDII/JP

27845, 32255, 36665

1386 VPI BAU2495D I38B 579B 10206, 14616, I9D26, 2343B, naravirus Hu/GII.4/Hakkaido2/20l2/JP

2784B, 32256, 3G666

1387 VPI BA024952 1387 5797 10207, 14617, 19027, 23437, narovirus Hu/GII.4/Hokkaida3/20l2/JP

27847, 32257.36667

1388 VPI BAU24954 1388 5798 10208, 14618, 10028, 23438, naravirus Hu/GII.4/Hokkaido5/20l2/JP

27848, 32258, 366B8

1389 VPI BAU24958 1389 5799 10209, 14619, 19029, 23439, norovirus Hu/GII,4/Anmori4/20l2/JP

27849, 32259, 36669

I39D VPI BAU249BD 1390 5800 10210, 14620, 19030, 23440. naravirus Hu/GII.4/Akital/20l2/JP

27850, 32260, 36670

1391 VPI BAU24962 1391 5801 10211, 14621, 19031. 23441, norovirus Hu/BH.4/Akita2/2DI2/JP

27851, 32261, 3B67I

1392 VPI BAU24964 1392 5802 10212, 14622, 19032, 23442, naravirus Hu/GII.4/Akita3/20l2/JP

27852.32262, 36672

1393 VPI BAU249BB 1393 5803 10213. I4B23, 19033, 23443. norovirus Hu/GII.4/lwatel/20l2/JP

27853.322B3, 36673

1394 VPI BAU24968 1394 5804 10214, 14624, 19034, 23444, norovirus Hu/GII.4/lwate2/20l2/JP

27854, 32264, 36674

1395 VPI BAU24972 1395 5805 10215, I4B25, 13035, 23445, norovirus Hu/GII.4/Aichi3/ZDI2/JP

27855, 32265, 3BB75

1396 VPI BAU24B74 1396 5806 10216. 14626, 19036, 23446, naravirus Hu/GII.4/Aichi4/20l2/JP

27856, 32266.3B676

1397 VPI BAU2497B 1397 5807 10217, I4B27, 19037, 23447, naravirus Hu/GII.4/Aichi5/20l2/JP

27857, 32267, 3BB77

1398 VPI BAU24978 1398 5808 10218, 14628, I9D38, 23448, norovirus Hu/GII.4/Aichi6/20l2/JP

27858, 32268, 36678

1399 VPI BAU24980 1399 5809 10219, 14629, 19039, 23449, narovirus Hu/GII.4/Ehime4/20l2/JP

27859, 32269, 36679

I4DD VPI BAU24982 I4D0 5810 I022D, 14630, 19040, 23450, naravirus Hu/GII.4/Niigata2/2DI2/JP

278B0, 32270, 3BB80

1401 VPI BAU24984 1401 5811 10221, 14631, 19041, 23451, narovirus Hu/GII.4/Tayamal/20l2/JP

27861, 32271, 36B8I 1402 VPI BA02498G 1402 5812 10222. 14632, 19042, 23452, norovirus Hu/GII.4/Toyama3/2DI2/JP

27862, 32272, 36682

1403 VPI BA024988 1403 5813 10223, 14633, 19043, 23453, nnrovirus Hu/GII.4/Toyama4/20l2/JP

27863, 32273, 36683

1404 VPI BA024990 1404 5814 10224, 14634, 19044, 23454, norovirus Hu/GII.4/Fukui5/20l2/JP

27864, 32274, 36684

1405 VPI BAU24992 1405 5815 10225, 14635, 19045, 23455, norovirus Hu/GII.4/0sakaCity3/20l2/JP

27865, 32275, 36685

I40G VPI BAU24994 I4DB 5816 ID226, 14636, I904B, 23456, norovipus Hu/GII.4/Hiroshimal/2DI2/JP

278B6, 32276, 36686

1407 VPI BAU2499B 1407 5817 10227, 14637, 19047, 23457, norovirus Hu/GII.4/Hiroshima2/20l2/JP

27867, 32277, 36B87

1408 VPI BA024998 1408 5818 10228, I4B38, 19048, 23458, norQvirus Hu/GII.4/Hiras ima3/20l2/JP

27868, 32278, 36688

1409 VPI BA025002 1409 5819 10229, I4B39, 19049, 23459, norovirus Hu/GII.4/Shimane2/20l2/JP

278B9, 32279, 36689

1410 VPI BA025004 1410 5820 IB230, 14640, I905D, 23460, norovirus Hu/GII.4/Shimane4/2DI2/JP

27870, 32280, 36690

1411 VPI ADN84676 1411 5821 10231, 14641, 19051, 23461, norovirus pig/0035/2007/K0

27871, 32281, 36691

1412 VPI BA B8870 1412 5822 10232, 14642, 19052, 234B2, norovirus sewage/GII/lnfluent/Nov2006/JPN

27872, 32282, 36692

1413 PI AAC54893 1413 5823 10233, I4B43, 19053, 234B3, norovirus isolates

27873, 32283, 3G693

1414 VPI AAW30I95 1414 5824 ID234, 14644, 19054, 23464, norovirus Hu/CI4/20D2/AU

27874, 32284, 36694

1415 VPI ABD3G49I 1415 5825 ID235, 14645, 19055, 23465, norovirus Hu/GII/Goulburn Valley G5I75

27875, 32285, 36695 A/I983/AUS

1416 VPI ABD3B494 1416 5826 10236, I4B4B, 19056, 3466, norovirus Hu/GII/Gnulburn Valley G5I75

27876, 32286, 36696 B/I983/AUS

1417 VPI ABD3G497 1417 5827 10237, 14647, 19057, 23467, norovirus Hu/GII/Goulburn VallEy G5I75

27877, 32287, 36697 C/I983/A0S

1418 VPI ABL74387 1418 5828 10238, 14648, 19058, 23468, norovirus Hu/GII.4/Dongen4B 2D0G/NL

27878, 32288, 36698 1419 VPI ABL74389 1419 5820 10239, 14B49. 19D59, 234B9, norovirus Hu/GII.4/0enHaag54/200B/NL

27879, 32289, 3BB99

1420 VPI ABL74397 I42D 5830 10240, 14B50, 190B0, 23470, norovirus Hu/GII.4/Nijmegenll5/200G/NL

27880, 32290, 3B70D

1421 VPI AB0445B2 1421 5831 10241, 14651. 13061. 23471, norovirus

27881.32291, 36701 Hu/Maizuru/0305l2/2003/JP/4B56

1422 VPI ABQ445B3 1422 5832 10242, 14652, 19062, 23472, norovirus Hu/0saka/0l03l4/200l/JP/3B34

27882, 32292, 36702

1423 VPI AB0445B4 1423 5833 10243. 14653, I9D63, 23473, norovirus Hu/Saga/0003l3/2000/JP/2876

27883, 32293, 36703

1424 VPI AB0445B5 1424 5834 10244, 14654, I9DB4, 23474, norovirus Hu/0saka/00032l/2000/JP/300B

27884, 32294, 36704

1425 VPI ABQ445BB 1425 5835 ID245, I4B55, 19065. 23475, norovirus Hu/AkabanE/99ll30/l9B9/JP/2258

27885, 32295, 3B705

1426 VPI ABQ445B7 I42B 583B I024B, I4B5B, I90B6, 2347B, norovirus Hu/Saga/OOI2l5/2000/JP/3IOI

2788B, 32296, 3B706

1427 VPI ABQ445B8 1427 5837 10247, 14657, 19067, 23477, norovirus

27887, 32297, 3B707 Hu/Maizuru/000602/2000/JP/2840

1428 VPI ABQ445B9 1428 5838 10248, 14658, 19D68, 23478, norovirus Hu/Maizuru/0I0524/200l/JP/3229

27888, 32298, 36708

1429 VPI ABQ44570 1429 5830 10249, 14659, 19D69, 23479, norovirus Hu/Osaka/OI0203/200l/JP/3BII

27889, 32299.36709

1430 VPI AB04457I 1430 584D ID250, 146B0. 19070. 23480, norovirus Hu/Osaka/OI0203/20DI/JP/3BI2

27890, 323D0, 36710

1431 VPI ABD44572 1431 5841 10251, 14661. 19071, 23481, norovirus Hu/ urume/a5l22B/f995/JP/4IB

27891, 32301, 36711

1432 VPI AB044573 1432 5842 10252, 14662, 19072, 23482, norovirus

27892.32302, 3B7I2 Hu/AkabanE/99020B/l999/JP/2087

1433 VPI ABQ44574 1433 5843 10253, 14BB3, 19073. 23483. norovirus

27893, 32303, 36713 Hu/Maizuru/OI0426/200l/JP/3385

1434 VPI AB044575 1434 5844 10254, 14664. 19074, 23484, norovirus

27894, 32304, 36714 Hu/ aizuru/000324/2000/JP/2468

1435 VPI ABQ4457B 1435 5845 10255, I4BB5, 19075, 23485, norovirus Hu/Dsaka/OI0228/200l/JP/3B25

27895, 32305, 3B7I5 1436 VP! ACJ04900 1436 5846 10256, 14666, 19076, 23486, norovirus Bo/GIII/BVI5/2007/BEL

27896, 32306, 36716

1437 VP! ACJ04B03 1437 5847 10257, 14667, 19077, 23487, norovirus BD/BIII/BV24/2007/BEL

27897, 32307, 36717

1438 VPI ACJ04906 1438 5848 10258, 14668, 19078, 23488, norovirus Bo/BIII/B309/2003/BEL

27898, 32308, 36718

1439 VP! ACY00565 1439 5849 10259, 14669, 19079, 23489, norovirus Hu/GII.4/Beijing/53952/2007/CHN

27899, 32309, 36719

I44D VPI ACYD0568 1440 5850 10260, 14670. 19080, 23490, norovirus Hu/GII.4/Beijing/54023/2007/CHN

27900, 32310, 36720

1441 VP! ACY0057I 1441 5851 10261, 14671, 19081, 23491, norovirus Hu/BII.4/Beijing/54091/2007/CHN

27901, 32311, 36721

1442 VPI ACY00573 1442 5852 10262, 14672, 19082, 23492, norovirus Hu/BII.4/Beijing/54IIB/2007/CHN

27902, 32312, 36722

1443 VPI ACY00576 1443 5853 10263, 14673, 19083, 23493, norovirus Hu/Gll.4/Beijing/54I25/20D7/CHN

27903, 32313, 36723

1444 VP! ACY00579 1444 5854 10264. 14674, 19084, 23494, norovirus Hu/GII.4/Beijing/54l35/2007/CHN

27904, 32314, 36724

1445 VPI ACY00582 1445 5855 10265, 14675, 19085, 23495, norovirus Hu/GII.4/B _E ijing/54B5l/2007/CHN

27905, 32315, 36725

1446 VPI ACY0D588 1446 5856 10266, 14676, 19086, 23496, norovirus Hu/GII.4/BBijing/55047/2007/CHN

27906, 32316, 36726

1447 VPI ACY00594 1447 5857 10267, 14677, 19087. 23497, norovirus Hu/GII.4/Beijing/55058/2007/CHN

27907, 32317, 36727

1448 VPI ACY00597 1448 5858 10268, 14678, 19088. 23498. norovirus Hu/GII.4/8eijing/55D65/2007/CHN

27908, 32318. 36728

1449 VPI ACY00600 1449 5859 10269, 14679, 19D89, 23499, norovirus Hu/GII.4/BEijing/55l50/2008/CHN

27009, 32319, 36729

1450 VPI ACYD0603 1450 5860 10270, 14680, 19090, 23500, norovirus Hu/GII.4/B _B ijing/55l62/2008/CHN

27910, 32320, 36730

1451 VPI ACY006D6 1451 5861 10271, 14681, 19091, 23501, norovirus Hu/Gll.4/Beijing/55l76/2008/CHN

27911, 32321, 36731

1452 VPI ACY00609 1452 5862 10272, 14682, 19092, 23502, norovirus Hu/GII.4/Beijing/55l84/2008/CHN

27912, 32322, 36732 1453 VPI ACYD06I2 1453 5863 10273, 14G83, 19093, 23503, norovirus Hu/GII.4/Beijing/54667/2007/CHN

27913, 32323, 36733

1454 VPI ACYDD6I5 1454 5864 10274, 14684, 19094, 23504, norovirus Hu/GII.4/Beijing/5367l/2007/CHN

27914, 32324, 36734

1455 VPI ACYDD6I8 1455 5865 10275, 14685, 19095, 23505, narovirus Hu/GII.4/BBijing/53937/2D07/CHN

27915, 32325, 36735

1456 VPI ACY0D62I 1456 5866 10276, 14686, 19096, 3506, norovirus Hu/GII.4/Beijing/55063/2DD7/CHN

27916, 32326, 36736

1457 PI ACYD0623 1457 5867 10277, 14687, 19097, 23507, norovirus Hu/GII.4/Beijing/55028/2007/CHN

27917, 32327, 36737

1458 PI ACY0D629 1458 5868 10278, 14688, 19098, 23508, narovirus Hu/GII.4/Beijing/5504D/2007/CHN

27918, 32328, 36738

1459 VPI ACYDD632 1459 5869 10279, 14689, 19099, 23509, norovirus Hu/GII.4/Beijing/55!85/2G08/CHN

27919, 32329, 36739

1460 VPI ACYDD635 I46D 587D 10280, 14690, 19100, 23510, norovirus Hu/GII.4/Beijing/5393l/2007/CHN

27920, 32330, 36740

1461 VPI ACY00638 1461 5871 10281, 14691, 19101. 23511, norovirus Hu/GII.4/Beijing/54l08/2007/CHN

27921, 32331, 36741

1462 VPI ACYDD64I 1462 5872 10282, 14692, 19102, 23512, norovirus Hu/GII.4/Beijing/54H4/2DD7/CHN

27922, 32332, 36742

1463 VPI ACYDD645 1463 5873 10283, 14693, 19103, 23513, narovirus Hu/GII.4/BBijing/54GGD/20D7/CHN

27923, 32333.36743

1464 VPI ACYDD647 1464 5874 10284, 14694. 19104, 23514, norovirus Hu/GII.4/Beijing/55042/2007/CHN

27924.32334, 36744

1465 VPI ACYDD650 1465 5875 10285, 14695, 19105, 23515, norovirus Hu/GII.4/B _E ijing/55IBI/2008/CHN

27925, 32335, 36745

1466 VPI ACYDD656 1466 5876 10286, 14696, 19106, 23516, narovirus Hu/GII.4/Beijing/55l7l/2008/CHN

27926, 32336, 36746

1467 VPI ADK47I70 1467 5877 10287, 14697, 19107, 23517. norovirus Hu/ll.4/220D66l/HK/2DI0

27927, 32337, 36747

1468 VPI A0R3D5I4 1468 5878 10288, 14698, 19108, 23518, norovirus Hu/BII.B/89l3/Shizuoka/2DD8/JPN

27928, 32338, 36748

1469 VPI A0R78255 1460 5879 10289, 14699, 19109, 23519, norovirus Hu/Il.4/222I223/HK/2D09

27929, 32339, 36749 I47D VPI ADR78259 I47B 5880 ID290, 14700, 13110. 23520, norovirus Hu/ll.4/2845694/HK/2009

27930, 32340.3B75B

1471 VPI ADR782G2 1471 5881 10291. 14701, I9III. 23521, norovirus Hu/H.4/2856357/HK/2009

27931, 32341, 3B75I

1472 VPI ADR782BB 1472 5882 IB292, 14702. 19112. 23522, norovirus Hu/ll.4/2849738/HK/2009

27932, 32342, 3B752

1473 VPI ADR782B8 1473 5883 10293, 14703, 19113. 23523, norovirus Hu/Il.4/220I480/HK/20I0

27933, 32343, 3B753

1474 VPI AFO00Q93 1474 5884 10294, 14704, 19114. 23524, norovirus Gill

27934, 32344, 3B754

1475 VPI BAI52939 1475 5885 10295, 14705, 19115, 23525, norovirus Hu/GII.2/OC08030B/2008/JPN

27935, 32345, 3B755

I47B VPI BAI5294D I47B 588B I029B, I470B. I9IIB, 2352B, norovirus Hu/GII.4/0C090053/2009/JPN

27936, 3234B, 3B75B

1477 PI BAQ2D80I 1477 5887 10297, 14707, 19117, 23527. norovirus Hu/Gll.4/Aichi368-I4/20I4

27337, 32347.3B757

1478 VPI BAQ2D803 1478 5888 10238, 14708, 10118. 23528, norovirus Hu/GII.4/AichiNishiol-!4/20l4

27938, 32348, 3B758

1479 VPI BAQ20805 1479 5889 10299, 14709. 19119, 23529, norovirus Hu/Gll.4/Aichi35l-I4/20I4

27939, 32349, 3B759

1480 VPI AABBB27I I48B 5890 10300, 14710, 19120, 23530. norovirus isolates

27940, 32350, 3B7B0

1481 VPI AAK9B2I8 1481 5891 10301. 14711, 1912!. 23531. norovirus Gil

27941, 32351, 3B7BI

1482 VPI AAR97B48 1482 5892 10302, 14712, 19122, 23532, norovirus Gil

27942, 32352, 3B7B2

1483 VPI AAR97B5I 1483 5893 10303, 14713, 19123, 23533, norovirus Gil

27943, 32353, 3B7G3

1484 VPI AAR97B54 1484 5894 ID304, 14714, 19124, 23534, norovirus Gil

27344, 32354, 3B7B4

1485 VPI AAR97B57 1485 5895 10305, 14715, 13125, 23535, norovirus Gil

27345, 32355, 36765

I486 VPI AAR37BBB I48B 589B IB30B, 14716. 13126, 23536, norovirus Gil

27346, 32356, 36766 1487 VPI AAR97BB3 1487 5897 10307, 14717, 19127, 23537. norovirus 611

27947, 32357. 36767

1488 VPI AAS8B774 1488 5898 10308, 14718, 19128, 23538. norovirus Gil

27948, 32358, 3B7B8

1489 VPI AAS86777 1489 5899 10309, 14719, 19129. 23539, norovirus Gil

27949, 32359. 3B7B9

1490 VPI AAS8B780 1490 5900 10310, 14720, 19130, 23540. norovirus Gl

27950, 323B0, 36770

1491 VPI AAS8B783 1491 5901 10311, 14721, 19131, 23541, norovirus Gl

27951, 32361, 3B77I

1492 VPI AAS8B78B 1492 5902 10312, 14722, 19132, 23542, norovirus Gil

27952, 32362, 36772

1493 VPI AAS8B792 1493 5903 10313, 14723, 19133, 23543. norovirus Gil

27953, 32363, 36773

1494 VPI AAS86795 1494 5904 10314, 14724, 19134, 23544, norovirus Gil

27954, 32364, 3G774

1495 VPI AAS8B798 1495 5905 10315, 14725, 19135, 23545, norovirus Gil

27955, 32365, 36775

1496 PI AAS8B80I I49B 5906 10316, 14726, 19136, 2354B, norovirus Gil

27956, 32366, 36776

1497 VPI AAS8B804 1497 5907 10317, 14727, 19137, 23547. norovirus Gil

27957. 32367, 36777

1498 VPI AAS8B807 1498 5908 10318, 14728, 19138, 23548, norovirus Gl

27958, 32368, 36778

1499 VPI AAT00237 1499 5909 10319, 14729, 19139, 23549, norovirus Hu/NLV/0xfard/B4S5/2002/UK

27959.32369, 36779

I5DD VPI AAT00240 1500 5910 10320, 14730. 19140, 23550, norovirus Hu/NLV/0xford/B4SG/2002/0K

27960. 32370, 36780

I5DI VPI AATD0243 1501 5911 10321, 14731, 19141. 23551. norovirus Hu/NLV/0xford/B4S4/2D02/U

27961. 32371, 36781

1502 VPI AAT0D24G 1502 5912 10322, 14732, 19142, 23552, norovirus Hu/NLV/0xford/B4S7/2002/UK

27962, 32372, 36782

1503 VPI AAT00249 1503 5913 10323, 14733, 19143, 23553, norovirus Hu/NLV/0xford/B4SI/2002/0

27963, 32373, 36783 1504 PI AAT00255 1504 5914 10324, 14734, 19144, 23554, norovirus Hu/NLV/Oxford/BISI/2002/OK

27064, 32374, 36784

I5D5 VPI AAT00258 1505 5915 10325, 14735, 19145, 23555, norovirus Hu/NLV/0xford/BIS2/2002/0K

27965, 32375, 36785

I5DB VPI AATD02GI I50G 5916 10326, 14736, 19146, 23556, norovirus Hu/NLV/0xford/B!S4/2DDZ/UK

27966, 32376, 36786

1507 VPI AAT002B4 1507 5917 10327, 14737, 19147, 23557, norovirus Hu/NLV/0xford/BISII/2002/UK

27967, 32377, 36787

I5D8 VPI AAT002B7 1508 5918 10328. 14738, 19148, 23558, norovirus Hu/NLV/0xford/BISI2/2002/0K

27968, 32378, 36788

I50B PI AAT00270 1503 5919 10329, 14739, 19149, 23559, norovirus Hu/NLV/0xford/BISI6/2002/0

27969, 32379, 36789

1510 VPI AAT00273 1510 5920 10330, 14740, 19150, 23560, norovirus Hu/NLV/0xford/BIS2l/2002/UK

27970, 32380, 36790

1511 VPI AATD027G 1511 5921 10331, 14741, 19151, 23561, norovirus Hu/NLV/0xford/B2SI0/2B02/0K

27971.32381, 36791

1512 VPI AAT00279 1512 5922 10332, 14742, 19152. 23562, norovirus Hu/NLV/0xford/B2SII/2002/0K

27972, 32382, 36792

1513 VPI AAT00282 1513 5923 10333, 14743, 19153, 23563, norovirus Hu/NLV/0xford/B2SI4/20B2/0

27973, 32383, 36793

1514 VPI AAT00285 1514 5924 10334, 14744, 19154, 23564, norovirus Hu/NLV/0xford/B2SI5/2002/UK

27974, 32384, 36794

1515 VPI AAT00288 1515 5925 10335, 14745, 19155, 23565, norovirus Hu/NLV/0xford/B2SI7/2002/UK

27975, 32385, 36795

1516 VPI AAT002BI 1516 5926 10336, 14746, 19156, 2356B, norovirus Hu/NLV/0xford/B2SI8/2002/UK

2797B, 32386, 3679B

1517 VPI AAT00294 1517 5927 10337. 14747, 19157, 23567, norovirus Hu/NLV/0xford/B2S20/2002/UK

27977, 32387, 36797

1518 VPI AAT002B7 1518 5928 10338. 14748. 19158, 23568, norovirus Hu/NLV/0xford/BZS23/2002/0K

27978, 32388.36798

1519 VPI AAT00300 1519 5929 10339, 14749, 19159, 23569, norovirus Hu/NLV/0xford/B2S24/2002/0

27979, 32389, 36799

1520 VPI AAT00303 1520 5930 10340, 14750, 19160, 23570, norovirus Hu/NLV/Dxford/B2S25/2002/0K

27980, 32390, 36800 1521 VPI AATDD3DB 1521 5931 10341. 14751, I9IBI. 23571, narovirus Hu/NLV/Dxfard/BZS2B/2DD2/UK

27981, 32391, 3B80I

1522 VPi AATD03DB 1522 5B32 10342, 14752, 19162. 23572, narovirus Hu/NLV/0xford/B3S4/2003/0K

27982, 32392, 3B802

1523 VPI AATD03I2 1523 5833 10343. 14753, 19163, 23573. narovirus Hu/NLV/Dxf _D rd/B3SIB/2DD3/UK

27983. 32393, 36803

1524 VPI AATDD3I5 1524 5934 10344, 14754, 19164, 23574, norovirus Hu/NLV/0xford/B3SI8/2Q03/0K

27984, 32394.368D4

1525 VPI AAT003I8 1525 5B35 10345. 14755, 19165, 23575, norovirus Hu/NLV/0xford/B3SI9/2003/U

27985, 32395, 36805

I52B VPI AATD032I I52B 533B 10346, 14756, 19166, 23576, narovirus Hu/NLV/0xford/B3S20/2003/0K

27986, 32396, 3B80B

1527 VPI AATDD324 1527 5B37 10347, 14757, 19167, 23577, norovirus Hu/NLV/0xford/B5SI/22002/0K

27987, 32397, 3G807

1528 VPI AATDD330 1528 5938 10348, 14758, 19168. 23578. norovirus Hu/NLV/0xford/B5S8/2002/UK

27988, 32398, 368D8

I52B VPI AATDD333 1523 5939 10349, 14759, 19169, 23579, naravirus Hu/NLV/0xford/B5S9/2002/UK

27989, 32399, 36809

1530 VPI AATDD33B I53D 5940 10350, 14760, 19170, 23580, narovirus Hu/NLV/0xford/B5SI0/2002/0K

279B0.32400, 36810

1531 VPI AATDD342 1531 5941 10351. 14761, 10171, 23581. norovirus Hu/NLV/0xford/B5SI9/2002/U

27991, 32401, 36811

1532 VPI AAT0D345 1532 5942 10352, 14762. 19172, 23582, norovirus Hu/NLV/Oxfard/B6S3/2003/UK

27992, 32402. 3G8I2

1533 VPI AATBD348 1533 5B43 10353. 14763. 19173, 23583. norovirus Hu/NLV/0xford/BGS6/2003/UK

27993, 32403, 36813

1534 VPI AAT0035I 1534 5944 10354, 14764, 19174, 23584, norovirus Hu/NLV/0xford/B6S2/2003/0K

27994, 32404, 3B8I4

1535 VPI AAT00354 1535 5945 10355, I47B5, 19175. 23585, norovirus Hu/NLV/0xfard/B5S23/2D03/UK

27995, 32405, 36815

I53B VPI AAT00357 I53B 594B 10356. 14766, 19176, 23586, norovirus Hu/NLV/0xford/BBS5/2003/UK

2799B, 32406, 3B8I6

1537 VPI AAT003BB 1537 5947 10357, 14767, 13177, 23587, norovirus Hu/NLV/0xford/BBS4/2003/0K

27997, 32407. 3B8I7 I538 VPI AATDD3B3 I538 5948 I0358, I47B8, I9I78, 23588, norovirus Hu/NLV/0xford/88S5/2002/UK

27998, 32408, 3B8I8

I539 VPI AAT003BB I539 5949 ID359, I47B9, I9I79, 23589, norovirus Hu/NLV/Didcat/B9S2/2003/0

27999, 32409, 36819

I540 VPI AATDD3B9 I540 5950 I03B0, I477D. 19180, 23590, norovirus Hu/NLV/ChippingNorton/2003/OK

28000, 32410, 3B820

I54I VPI AAT0D372 I54I 595I I03BI, 14771, 19181. 23591, norovirus Hu/NLV/Banbury/B9S23/2003/UK

28001, 32411, 3B82I

I542 VPI AAT00375 I542 5952 ID3B2, 14772, 13182, 23592, norovirus Hu/NLV/Witney/B7S2/2Q03/U

28002, 32412, 3B822

I543 VPI AAT70II0 I543 5953 I03B3, 14773, 10183, 23593. norovirus NLV/Paris lsland/2003/0SA

28003, 32413, 3B823

I544 VPI AAT735B2 I544 5954 I03B4, 14774, 19184. 23594, norovirus NLV/B0DS/2002/USA

28004, 32414, 3B824

I545 VPI AAT7848D I545 5955 I03B5, 14775, 13185, 23595, norovirus NLV/IFI998/2003/lraq

28005, 32415, 3B825

I54B VPI AAT7848I I54B 595B I03BB, I477B. 19186. 2359B, norovirus NLV/IF203B/2D03/lraq

28006, 32416.36826

I547 VPI AAU9577B I547 5957 I03B7, 14777, 19187, 23597, norovirus Hu/NLV/Dresdenl74/pUS- 28007, 32417, 3B827 Norll/1997/GE

I548 VPI AAX32874 I548 5958 I03B8, 14778, 19188, 23598. norovirus swine/GII/MI-BW48/02/0S

28008.32418, 36828

I549 VPI AAX32877 I549 5959 I03B9, 14779, 19189, 23599, norovirus swine/GII/0H-QWIBI/03/0S

28009, 32419, 3B829

I55D VPI AAX32880 I55B 59B0 10370, 14780, 19190, 23B00, norovirus swine/GII/0H-QWI25/03/0S

28010, 32420, 3B830

I55I VPI AAX3288B I55I 59BI 10371, 14781, 19191, 23B0I, norovirus swine/Gll/DH-QW2l8/D3/US

28011, 32421, 3B83I

I552 VPI AAZ3I37B I552 59B2 10372, 14782. 19192, 23B02, norovirus Hu/GI /Hunter 284E/O40/A0

28012, 32422, 3B832

I553 VPI AAZ3I39B I553 59B3 10373, 14783, 19193. 23603. norovirus Hu/GII.4/Hunter504D/D40/AU

28013.32423, 3B833

I554 VPI AAZ3I4D2 I554 59B4 10374, 14784, 19194, 23B04, norovirus Hu/GII.4/Sydney9l7J/020/AU

28014, 32424, 3B834 1555 VPI AAZ3I4II 1555 59B5 10375. 14785, 19195. 23605, norovirus Hu/GII.4/Sydney348/970/AU

28015. 32425. 36835

1556 VPI AAZ3I423 1556 5966 10376, I478B, 19196. 23606. norovirus Hu/BEf.4/Sydney7l5D/04S/AU

28016, 32426, 36836

1557 VPI AAZ3I428 1557 59G7 10377, 14787, 19197, 236D7, norovirus Hu/GII.4/Sydney4477/DZS/AU

28017, 32427.36837

1558 VPI ABBD242D 1558 59B8 10378, 14788, 19198, 23608, murine norovirus 3

28018, 32428, 36838

1558 PI ABBD2423 1559 59G9 10379, 14789, 19199. 23609, murine norovirus 4

28019, 32429.36839

I5BD VPI ABC9B74G 15GB 5370 10380, 14790, I920D, 23GI0, norovirus Gil

28020, 32430, 3B840

1561 VPI ABD77588 1561 5971 10381, 14791, 19201, 23611, norovirus Hu/Beijing/CR2905/2DD4/CHN

28021, 32431, 36841

1562 VPI ABD77589 1562 5972 10382, 14792, 19202, 23BI2, norovirus Hu/Beijing/CR2932/2004/CHN

28022, 32432, 36842

1563 VPI ABD7759B I5B3 5973 10383, 14793, 19203, 23613, norovirus Hu/Beijing/CR2987/2004/CHN

28023, 32433, 3B843

1564 VPI ABG45845 I5G4 5974 10384, 14794, 19204, 23614, murine norovirus

28024, 32434, 36844

1565 VPI ABG45847 1565 5975 10385, 14795, 19205, 23GI5, murine norovirus

28025, 32435, 3B845

1566 VPI ABG45849 1566 5976 10386, I479G, I92DB, 23BI6, murine norovirus

28026, 3243G, 36846

1567 VPI ABG4585I 1567 5977 10387. 14797. 19207. 23617, murine norovirus

28027. 32437. 3G847

1568 PI ABI95835 1568 5978 10388, 14798, I92D8, 23618, murine norovirus

28028, 32438, 3G848

1569 VPI ABI9798I 1569 5979 10389, 14799, 19209, 23GI9, norovirus Hu/GII-4/0saka/l998/JPN

28D29, 32439, 36849

I57D VPI ABP99D38 I57D 5980 10390, I48D0, 19210, 23B20, murine norovirus

2803D, 32440, 36850

1571 VPI ABP9904I 1571 5981 10391, 14801, 19211, 23B2I, murine norovirus

28031, 32441, 3G85I 1572 VPI ABBI2784 1572 5B82 10392. 14802. 19212, 23B22. norovirus Hu/GII/TorontD/SK/2005/CAN

28B32, 32442, 3B852

1573 VPI AB I5783 1573 5383 10333, 14803, 18213, 23B23, norovirus lion/GIV,2/Pistoia/387/0B/ITA

28033, 32443, 3B853

1574 VPI ABR24I3B 1574 5B84 10394, 14804, 19214, 23B24, norovirus Hu/Euangzhou/NV- 28B34, 32444, 3B854 VP2/2B06/China

1575 VPI ABSI2I73 1575 5385 10335, 14805, 19215, 23B25. norovirus Hu/Hebet/4858D/2DDG/CHN

28035, 32445, 3B855

I57B VPI ABSI2I75 I57B 598B 10396, I480B, 18216. 23B26, norovirus Hu/Shanxi/50106/2006/CHN

28036, 32446, 36856

1577 VPI ABS29273 1577 5387 10337. 14807, 13217, 23B27, murine norovirus 5

28037, 32447, 36857

1578 VPI ABS29275 1578 5388 10398, 14808, 19218, 23B28, murine norovirus 6

28D38, 32448, 36858

I57B VPI ABU5554I 1573 5383 10399, 14809, 19219. 23629. murine norovirus 1

28039, 32449, 3S85S

1580 VPI ABU55544 1580 539B 10400. 14810. 13220, 23630, murine norovirus 1

28040, 32450, 36860

1581 VPI ABU55547 1581 5331 10401, 14811, 13221, 23B3I, murine norovirus 1

28041, 32451, 3B86I

1582 VPI ABU55550 1582 5332 10402, 14812. 19222, 23632, murine norovirus 1

28B42, 32452, 3B86Z

1583 VPI ABU55553 1583 5933 10403, 14813, 19223, 23633, murine norovirus 1

28043, 32453, 36863

1584 VPI ABU5555B 1584 5394 10404, 14814, 19224, 23634, murine norovirus 1

28044, 32454, 36864

1585 VPI ABU5555B 1585 5335 10405, 14815, 19225, 23635, murine norovirus 1

28045, 32455, 3B865

I58B VPI ABU555B2 I58G 533B I040B, 14816, 19226, 23636, murine norovirus 1

28046, 32456, 36866

1587 VPI ABU555B5 1587 5997 10407, 14817, 19227, 23637, murine norovirus 1

28047, 32457, 36867

1588 VPI ABU555B8 1588 5998 10408, 14818, 19228, 23638. murine norovirus GV/WUII/2005/USA

28048, 32458, 36868 1589 VPI ABU5557I 1589 5999 10409, 14819, 19229, 23B39, murine norovirus GV/WUI2/2G05/0SA

28049.32459, 3B8B9

I59D VPI AB055577 1590 BOOO 10410, 14820, 19230, 23B4D, murine norovirus GV/W02I/2005/USA

28050, 324B0, 3B870

1591 VPI ABU55580 1591 BOOI 10411, 14821. 19231, 23B4I, murine norovirus GV/W022/2005/0SA

28051, 324GI, 3B87I

1592 VPI AB05558B 1592 B002 10412. 14822, 19232, 23B42, murine norovirus GV/WU24/20D5/0SA

28D52, 324G2, 3B872

1593 VPI ABU55589 1593 B003 10413, 14823, 19233, 23B43, murine norovirus GV/WU25/2005/USA

28053, 324B3, 3B873

1594 VPI ABU55598 1594 B004 10414, 14824, 19234, 23B44, murine norovirus GV/CR3/2005/USA

28054, 324B4.3G874

1595 VPI ABU55B0I 1595 B005 10415. 14825, 19235, 23G45, murine norovirus GV/CR4/2005/USA

28055, 324B5, 3B875

159G VPI ABU55B04 I59B BOOB 10416. 14826, 19236, 23B4B. murine norovirus GV/CR5/2D05/USA

2805B, 324BB.36876

1597 VPI ABU55B07 1597 B007 10417, 14827, 19237, 23647, murine norovirus GV/CRG/2005/USA

28057, 32467, 36877

1508 VPI AB055BID 1598 B008 ID4I8, 14828, 19238, 23B48, murine norovirus GV/CR7/2D05/0SA

28058, 324B8, 36878

1599 VPI AB0556I3 1590 B009 10419, 14829, 19239, 23649. murine norovirus GV/CRI0/2005/USA

28059, 32469, 3B879

1600 VPI AB055BIB IBOO BOIO 10420, 14830, 19240, 23650, murine norovirus GV/CRII/2005/USA

28060, 32470, 36880

IBOI VPI ABU55BI9 IBOI BOH 10421, 14831, 19241, 23B5I. murine norovirus GV/CRI3/2005/USA

28D61, 32471. 3B88I

IB02 VPI ABU55B22 IB02 B0I2 10422, 14832, 19242. 23B52. murine norovirus GV/CRI5/2005/USA

28062, 32472, 36882

1603 PI ABU55B28 IB03 B0I3 10423, 14833, 19243, 23653, murine norovirus GV/CRI8/2005/DEU

28063, 32473, 36883

IB04 PI ABW74I2I IG04 B0I4 10424. 14834, 19244, 23B54. norovirus

28064, 32474, 36884 Hu/GU/Mussels/MI0nov2004/Foto/Sweden

IBD5 VPI ABW74I23 IB05 B0I5 10425, 14835, 19245, 23655, norovirus

28065, 32475, 3B885 Hu/GI.I/ ussels/M8nov2004/Foto/Sweden IBOB VPl ABW74I24 1606 6016 10426, 14836, 19246, 2365B, norovirus

280B6, 32476, 36886 Hu/GI.I/P738.DBlsjoZ0D4/GothBnburg/SwBdB

n

IB07 VPl ABW74I25 IB07 B0I7 10427, 14837, 19247, 23657, norovirus

28067, 32477, 36887 Hu/GI,l/MussEls/ I27nnv2004/FatD/SwEden

IBD8 VPl ABW74I2B IB08 B0I8 10428, 14838, 19248, 23658, naravirus

280B8, 32478, 36888 Hu/GU/P725.DBlsjo20D4/GothBnbijrg/SwEdE

n

IBD9 VPl ABW74I27 IB09 6019 10429, 14839, 19249, 23659, norovirus

28069, 32479, 36889 Hu/Gl.l/P7l5.0eisjo2DD4/Biithenburg/Sweden

1610 VPl ABW74I28 1610 602D 10430, 14840, 19250, 23660, norovirus

28070, 32480, 36890 Hu/BI.I/P774.DelsjD2D04/Gothenburg/Swede n

IBII VPl ABW74532 IBII 6021 10431, 14841, 19251, 23661, norovirus Hu/ ichmond/1994/OSA

28071, 32481, 36891

1612 VPl ABW74533 1612 6022 10432, 14842, 19252, 3662, norovirus Hu/Haustan/I995/USA

28072, 32482, 36892

1613 VPl ABW74534 1613 6023 10433, 14843, 19253, 23B63, norovirus Hu/Lonacaning/2001/USA

28073, 32483, 36893

1614 VPl ABW74535 1614 6024 10434, 14844, 19254, 23664, norovirus Hu/WarrBn/2002/USA

28074, 32484, 36894

1615 VPl ABW74536 1615 6025 10435, 14845, 19255, 23665, norovirus Hu/GCanyon/2002/USA

28075, 32485, 36895

1616 VPl ABW74537 1616 6026 10436, 14846. 10256, 2366B, norovirus Hu/QM2-CS/2004/0SA

2807B, 32486, 36896

1617 VPl ABW74538 1617 6D27 10437, 14847, 19257, 236B7, norovirus Hu/FL04/2004/USA

28077, 32487, 36897

1618 VPl ABW74539 1618 6028 10438, 14848, 19258, 23B68, norovirus Hu/GA04/2004/USA

28078, 32488, 36898

1619 VPl ABW7454B 1619 6029 10439, 14849, 19259, 23669, norovirus Hu/CumbBrland/2DG4/0SA

28079, 32489, 36899

I62D VPl ABW7454I 1620 6030 10440, 14850, 19260, 23670, norovirus Hu/Ryndam/2005/USA

28080, 32490, 36900

1621 VPl ABW74542 1621 6031 10441, 14851, 19261, 23671, norovirus Hu/Billings/200G/USA

28081, 32491, 36901 1622 VPI ABW74544 IB22 BB32 10442, 14852, I92B2, 23B72, norovirus Hu/Mississip/2006/USA

28B82, 32492, 36902

IB23 VPI ABW74545 1623 6G33 10443, 14853, 19263, 23673. norovirus Hu/CL-CS/2006/USA

28083, 32493, 36903

IB24 PI ABW7454B IB24 BB34 10444, 14854, I92B4, 23674, norovirus Hu/MT0I/20DG/0SA

28084, 32494, 36B04

IB25 VPI ABW75843 IB25 BG35 10445, 14855, 19265, 23675, norovirus sheep/NDrsEWQod30/20D7/NZL

28085, 32495, 3B9B5

IG2B VPI ABX7I0B2 IB2B BB3B I044B, I485B, I92BB, 23676, norovirus dog/170/07/lta

28086, 32496, 36906

IB27 VPI ABY77754 IB27 B037 10447, 14857, I92B7, 23677, norovirus Hu/GII/LuckBnwaldE59l/2002/DE

28087, 32497, 36907

IB28 VPI ABZ8B549 IB28 BB38 10448, 14858. 19268, 23678, norovirus Hu/GII/LevErkusBn267/2005/DE

28088, 32498. 36908

1628 VPI ACC68023 I62B BD33 10449, 14859, 19269, 23B79, norovirus pig/GIUi/FI8-IO/2005/CAN

28089, 32498. 369D9

1630 VPI ACC69D2B IB30 BD4D 10450, 1486D, 19270. 23B80, norovirus pig/GII.II/FI2-8/20D5/CAN

28090, 32500, 36910

IB3I VPI ACC69D28 IB3I B04I 10451, 14861. 19271. 23B8I, norovirus pig/GII-l8/FI5-IOnv/CAN

28091, 32501, 36911

IB32 VPI ACC9B732 IG32 B042 10452, 14862, 19272, 23682, norovirus mouse/TW2006/TWN

28092, 32502. 36912

1633 VPI ACC9B735 IB33 B043 10453, 14863, 19273, 23683, norovirus mousE/TW2007/TWN

28093, 32503, 36913

IB34 VPI ACF4II77 IB34 B044 10454, 14864, 19274, 23684, narovirus Hu/GII/BEijing/30/2004/CHN

28084, 32504, 36814

IG35 VPI ACF4II8B IG35 BD45 10455, 14865, 19275, 23685. norovirus Hu/BII/BEijing/22l/2005/CHN

28095, 32505, 36915

I63B VPI ACF4II8I IB3B BQ4B 10456, 14866, 19276, 23686, norovirus Hu/GII/BEijing/274/2005/CHN

28096, 325D6, 36916

IB37 VPI ACF4II82 IB37 B047 10457, I48B7, 19277, 23B87, norovirus Hu/GII/Beijing/484/2005/CHN

28097, 32507, 36917

IB38 VPI ACF4II83 IB38 BB48 ID458, 14868, 19278, 23688, norovirus Hu/GII/BEijing/493/2005/CHN

28098, 32508, 36918 1639 VPI ACF4II84 1639 6D49 10459. 14869, 19279, 23689, norovirus Hu/GII/BBijing/07/2006/CHN

28099, 32509, 36919

1640 VPI ACF4II85 I64D 6D50 10460, 14870, 1928D. 23690, norovirus Hu/GII/Beijing/34/2006/CHN

28100, 32510, 36920

IG4I VPI ACF4II86 1641 6Q5I 10461, 14871, 19281, 23691, norovirus Hu/GII/Beijing/IIG/2007/CHH

28101, 32511, 36921

IG42 VPI ACF4II87 1642 6D52 10462. 14872, 19282. 23692, norovirus Hu/GII/Beijing/125/2007/CHN

28102, 32512, 36922

1643 VPI ACF4II88 1643 6D53 10463. 14873, 19283, 23693, norovirus Hu/GII/Beijing/127/2007/CHN

28103, 32513, 36923

1644 VPI ACF4II9Q 1644 6D54 10464. 14874, 19284, 23694, norovirus Hu/GII/BBijing/3BI/2007/CHN

28104. 32514, 36924

1645 VPI ACF4II9I 1645 6Q55 10465, 14875, 19285, 23695, norovirus Hu/GII/Beijing/3G2/2007/CHN

28105. 32515. 36925

1646 VPI ACF60293 1646 GD56 10466, 14876, 19286, 23696, norovirus Hu/Beijing/OB/2005/CHN

28I0G, 32516, 36926

1647 VPI ACF6D294 1647 G057 10467, 14877. 19287, 23697, norovirus Hu/Beijing/48/2005/CHN

28107, 32517, 36927

1648 VPI ACF6Q295 1648 6D58 10468, 14878, 19288, 23698, norovirus Hu/BEijing/148/2005/CHN

28108, 32518, 36928

1649 VPI ACFGD29G 1649 6059 I04G9, 14879, 19289, 23699, norovirus Hu/Beijing/169/2005/CHN

28109, 32519, 36929

I65Q VPI ACFGD297 I65D 6060 10470, 14880. 19290, 23700, norovirus Hu/BEijing/375/2005/CHN

28110, 32520, 36930

1651 VPI ACF72688 1651 6061 10471, 14881, 19291. 23701, norovirus mousE/HannovErl/2007/DE0

28111, 32521, 3G93I

1652 VPI ACH42093 1652 6062 10472, 14882, 19292, 23702, norovirus Hu/Monastir 8B55/20D7/TUN

28112, 32522, 36932

1653 VPI ACH42094 1653 6063 10473, 14883. 19293, 23703, norovirus Hu/Monastir 127/2003/TUN

28113, 32523, 36933

1654 VPI ACH42Q96 1654 6064 10474, 14884, 19294, 23704, norovirus Hu/Monastir 529/2003/TON

28114, 32524, 36934

1655 VPI ACH42097 1655 6065 10475, 14885, 19295, 23705, norovirus Hu/Monastir 493/2003/TUN

28115, 32525. 36935 IB5B VPI ACH42D98 1656 BDG6 I047B, I488B, 19296, 23706, norovirus Hu/Monastir 715/2003/TON

28116, 3252B, 36936

IB57 VP! ACJ6G263 1657 6067 10477, 14887, 19297, 23707, norovirus Hu/GGII,4/Cairo2/2006/EGY

28117, 32527, 36937

IB58 VPI ACJB6265 1658 60B8 10478, 14888, 19298, 23708, norovirus Hu/GGII.4/Cairo3/20DG/EGY

28118, 32528, 36938

1659 VPI ACJBB2B7 1659 6069 10479, 14889, 19209, 23709, norovirus Hu/GGII.4/Caira4/2006/EGY

28119, 32529, 36939

IBBO VPI ACJB6269 1660 6070 10480, 14890. 19300, 23710, norovirus Hu/GGII.4/Cairo5/2006/EGY

28120, 32530, 36940

IBBI VPI ACJBB27I 1661 6071 10481, 14891, 19301, 23711, norovirus Hu/GGII.4/Cairo6/2D06/EGY

28121, 32531, 36941

1662 VPI ACJ66273 1662 6072 10482, 14892, 19302, 23712, norovirus Hu/GGII.4/Cairo7/2007/EGY

28122, 32532, 36942

IBG3 VPI ACJ66275 1663 6073 10483, 14893, 19303, 23713. norovirus Hu/GGII,4/Cairo8/2007/EGY

28123, 32533, 36943

IBB4 VPI ACJBB279 IB64 B074 10484, 14894, I93D4, 23714, norovirus Hu/GGII.4/Dijon-EI057/2D02/FRA

28124, 32534, 3B944

IBB5 VPI ACJBB28I 1665 6075 10485, 14895, 1930S, 23715, norovirus Hu/GGII.4/Dijon-E2703/2008/FRA

28125. 32535, 36945

IGBG VPI ACJB6283 1666 6076 10486, 14896, 19306, 23716, norovirus Hu/GGII.4/Cairol/20DB/EGY

28126, 32536, 36946

IBB7 VPI ACJ66285 1667 6077 10487, 14897, 19307, 23717, norovirus Hu/GGII.4/0ijon-EI50l/2006/FRA

28127, 32537, 36947

1668 VPI ACJ66286 1668 6078 10488, 14898, 19308, 23718, norovirus Hu/GGII.4/0ijon-EI267/200B/FRA

28128, 32538, 36948

1669 VPI ACJ722I6 1669 6079 10489, 14899, 19309, 23719, murine norovirus 4

28129, 32539, 3B949

1670 VPI ACL27297 1670 6080 10490, 14900, 19310, 23720, norovirus Hu/GII.4/Wellington/l995/USA

28130, 32540, 36950

1671 VPI ACL27298 1671 6081 10491, 14901, 19311, 23721, norovirus Hu/GII.4/Henry/2000/USA

28131, 32541, 36951

IB72 VPI ACL27299 IB72 6082 10492, 14902, 19312, 23722, norovirus Hu/GII.4/SSCS/20D5/USA

28132, 32542, 3B952 1673 VPI ACL273DD IB73 BD83 10493, 14903, 19313, 23723. norovirus Hu/GII.4/ IS/200B/0SA

28133, 32543, 36953

1674 PI AGL3I3I2 IB74 B084 10494, 14904, 19314, 23724, norovirus GII/Hu/IN/200G/GII.P4_GII.4_

28134, 32544. 36954 Yerseke2006a/Pune-PCII

IB75 VPI ACL3I3I3 IG75 GD85 10495, 14905, 19315, 23725, norovirus GII/Hu/IN/2006/GII.P4_GII.4_

28135, 32545, 36955 Hunter2D04/Pune-PCI2

IB7B VPI ACL3I3IB IB7B BD8B I049B, 14906, 19316. 23726. norovirus Hu/Pune/PCI5/2006/lndia

28136, 3254B, 3B95B

IB77 VPI ACL3I3I7 IB77 B087 10497, 14907, 19317, 23727, norovirus GII/Hu/IN/2006/GII.P4_GII.4_

28137, 32547, 36B57 Yerseke2006a/Pune-PCIG

IB78 VPI ACL3I3I3 IB78 BQ88 10498, 14908, 19318, 23728, norovirus GII/Hu/IN/2006/GII.P4_GII.4_

28138, 32548, 36958 Yerseke2006a/Pune-PCI8

IB79 VPI ACL3I32D IB7B BD8B 10499, 14909, 19319, 23729, norovirus BII/Hu/IN/ZDDB/GII.P4_GII.4_

28139, 32549, 36959 YBrsekB2006a/Pune-PCI9

IBSD VPI ACL3I322 IB8Q GD9D 10500, 14910, 19320, 23730, norovirus GII/Hu/IN/200G/GII.P4_GII.4_

28140, 32550, 36360 YersEke200Ga/Pune-PC2l

IB8I VPI ACL3I324 IB8I BD3I 10501, I4SII, 19321, 23731, norovirus GII/Hu/IN/200B/GII.P4_GII.4_

28141, 32551, 36961 YBrseke2006a/Pune-PC23

IB82 VPI ACL3I325 IB82 BD32 10502, 14912, 19322, 23732, norovirus Hu/Pune/PC24/2D0B/lndia

28142, 32552, 3B962

1683 VPI AGL3I32B IB83 6093 10503, 14913, 19323, 23733, norovirus Hu/PunE/PG25/2DD6/lndia

28143, 32553, 36963

IB84 VPI ACL3I34D IB84 BD94 10504, 14914, 19324, 23734. norovirus GII/Hu/IN/2007/GII.P4_GII.4_

28144, 32554, 36964 Hunter2004/Pune-PC3l

IB85 VPI ACL3I354 1685 6095 10505, 14915, 19325, 23735. norovirus GII/Hu/IN/2007/GII.P4_GII.4_

28145, 32555, 36965 DenHaag2006b/Pune-PC45

IB8B VPI ACL3I355 IB8B 6096 10506, 14916. 19326, 2373B, norovirus GII/Hu/IN/2DD7/GII.P4_GII.4_

28146, 32556, 3696B DenHaag200Bb/Pune-PC46

IB87 VPI ACL3I35B IB87 6097 10507, 14917. 19327, 23737, norovirus GII/Hu/IN/2DD7/GII.P4_GII.4_

28147, 32557, 36967 DenHaag2006b/Pune-PC47

IB88 VPI AGL3I358 IB88 6098 10508, 14918, 19328, 23738, norovirus GII/Hu/IN/2007/GII.P4_GII.4_

28148, 32558, 36968 DenHaag200Gb/PunE-PC49 1680 VPI ACL3I36I 1689 6099 10509. 14919. 19329, 23739, norovirus Hu/Pune/PC52/2007/lndia

28149, 32559, 36969

I69D VPI ACL3I365 I69D 6100 10510, 14920, 19330. 23740. norovirus GII/Hu/IN/2007/GII.P4_GII.4_

28150.32560. 36970 DenHaag2006b/PunB-PC56

1691 VPI ACL36375 1691 6101 10511. 14921, 19331, 23741, norovirus Hu/GII-4/C0K-3/2008/

28151, 32561, 36971

1692 VPI ACN3227D 1692 6102 10512, 14922, 19332. 23742. norovirus Hu/GI.I/P7- 28152.32562, 36972 587/2007/Stromstad/Sweden

1693 VPI ACT524D3 1693 6103 10513, 14923, 19333, 23743, norovirus Hu/CHN42973/CZ05

28153, 32563.36973

1694 VPI ACT524D5 1694 6104 10514, 14924. 19334, 23744, norovirus Hu/CHN39l86/CC04

28154, 32564, 36974

1695 PI ACT52407 1695 6105 10515, 14925, 19335, 23745, norovirus Hu/CHN39246/CCD4

28155, 32565, 36975

1696 VPI ACT524D9 1696 6106 10516, 14926, 19336, 23746, norovirus Hu/CHN4I808/LL04

28156, 32566, 36976

1697 VPI ACT78459 1697 6107 10517, 14927, 19337, 23747, norovirus Hu/Mannheiml3l/2009/DE

28157, 32567.36977

1698 VPI ACU56258 1698 6108 10518, 14928, 19338, 23748, norovirus Hu/GI.2/Leuven/2003/BEL

28158, 32568, 36978

1699 VPI ACX33982 1699 6109 10519. 14929, 19339, 23749, norovirus Hu/GI.3/JKPG_88l/SWE/2007

Z8I59, 32569, 36979

I7DD VPI ACX33983 I7D0 6110 ID520, 14930, 19340, 23750, norovirus Hu/GI.3/JKPG_883/SWE/2007

28160, 32570, 36980

1701 VPI ACX8I34I 1701 6111 10521. 14931, 19341, 23751, norovirus

28161, 32571, 36981 Hu/GII.I4/8533/Maizuru/2008/JPN

I7D2 VPI ACX8I343 1702 6112 10522, 14932, 19342, 23752, norovirus Hu/GII.I4/8542/Maizuru/2008/JPN

28162, 32572, 36982

I7D3 VPI ACX8I345 1703 6113 10523, 14933, 19343, 23753, norovirus

28163, 32573, 36983 Hu/GII.I4/8533/Maizuru/2008/JPN

I7D4 VPI ACX8I347 1704 6114 10524, 14934, 19344, 23754, norovirus

28164, 32574, 36984 Hu/GII.I4/8559/Maizuru/2008/JPN

I7D5 VPI ACX8I349 1705 6115 10525, 14935, 19345, 23755, norovirus

28165, 32575, 36985 Hu/GII.I4/8560/Maizuru/20D8/JPN I7DB VPI ACX8I35I I7QB 6116 I052B, 14936, 19346, 23756, narovirus Hu/GII.I4/859l/Maizuru/2008/JPN

28166, 32576, 36986

I7D7 VPI ACX8I353 I7D7 6117 10527, 14937, 19347, 23757, norovirus Hu/GII.I4/8594/Maizuru/2008/JPN

28167, 32577, 36987

I7D8 VPI ACX8I355 I7D8 6118 10528, 14938. 19348, 23758, norovirus

28168, 32578, 36988 Hu/GII.I4/8599/Maizuru/2008/JPN

I7D9 VPI ACX858DB 1709 6110 10529, 14939, 19349, 23759, norovirus Hu/GII.4/NSW023C/2008/AOS

28169, 32579, 36989

I7ID VPI ACX85807 1710 BI20 10530, 14940, 19350, 23760, norovirus Hu/Gll.b- 28170. 32580, 36990 GII.3/Sydney740C/2007/AUS

I7II VPI ACX858D9 1711 BI2I 10531, 14941, 19351, 23761. norovirus Hu/GII.7/NSWD88L/2007/A0S

28171, 32581, 36991

I7I2 VPI ACX858ID 1712 BI22 10532, 14942, 19352, 23762, norovirus Hu/GII.7/NSW743L/2008/AUS

28172, 32582, 36992

I7I3 VPI ACY4II55 1713 6123 10533, 14943, 19353, 23763, norovirus cattle/BV4l6/2008/BEL

28173, 32583, 36993

I7I4 VPI ADA77528 1714 6124 10534, 14944, 19354, 23764, norovirus Hu/GII-4/Beijing/hl/2005/CHN

28174, 32584, 36994

I7I5 VPI ADB225I2 1715 6125 10535, 14945, 19355, 23765, norovirus Hu/Ahm/PC03/2006/lndia

28175, 32585. 36995

I7IB VPI ADC9I993 1716 6126 10536, 14946, 19356, 23766, norovirus Hu/GII.4/Chungnam(ll- 28176, 32586, 36996 94)/2008/Kor

I7I7 VPI ADC0I904 1717 6127 10537, 14947, 19357, 23767, norovirus Hu/GII.4/Chungnam(l2- 28177, 32587, 36997 I07)/20D8/Kor

I7I8 VPI ADE287DI 1718 6128 10538, 14948, 19358. 23768, norovirus Hu/GII.I4/86IO/Saga/2008/JPN

28178, 32588, 36998

i7ia VPI ADE2872I 1719 6129 10539, 14949, 19359. 23769, norovirus Hu/GII.B/89l5/Maizuru/2008/JPN

28179, 32589, 36999

172D VPI ADE28722 1720 6130 10540, 14950, 19360, 3770, norovirus Hu/GII.6/8920/Maizuru/2008/JPN

28180, 32590, 37000

1721 VPI ADE28723 1721 6131 10541, 14951, 19361, 23771. norovirus Hu/GII.G/8966/Maizuru/2008/JPN

28181, 32591, 37001

1722 PI ADE28724 1722 6132 10542, 14952, 19362, 23772, norovirus Hu/GII.6/9088/Maizuru/2D08/JPN

28182, 32592, 37002 1723 VPI ADK23787 1723 BI33 10543, 14953. I93B3, 23773, norovirus Hu/Gi!.3/GBNUt/2DDB/KD

28183, 32593, 7D03

1724 VPI ADM52743 1724 BI34 10544, 14954, 19364, 23774, norovirus Hu/Gll.4/JB-I5/KOR/2008

28184, 32594, 37004

1725 VPI ADR57234 1725 BI35 10545, 14955, I93G5, 23775, norovirus Hu/GII.4/8483/2008/ZAF

28185, 32595, 370D5

1726 VPI AEA077I2 I72B BI3B I054B, I495B, 193GB. 2377B. murine norovirus

28I8B, 32596, 37006

1727 VPI AEK053II 1727 BI37 10547, 14957, 19367, 23777. norovirus Hu/GII.4/TH-S597/THA/2006

28187, 32597, 370D7

1728 VPI AEPIB505 1728 BI38 10548, 14958, 19368, 23778, norovirus Hu/Gllg- 28188, 32598, 37008 GII!/Kazincbarcika/HUN4593/20IO/HUN

1729 VPI AEY773I8 1729 BI39 10549, 14959. 19369, 23779, norovirus Hu/GI.3/S29/2008/Lilla

28189, 32599, 37009 Edst/Sweden

1730 VPI AEY83583 1730 BI4D 10550, 149B0, 19370, 23780, murine norovirus GV/CR6/2005/USA

28190, 32600, 37010

1731 VPI AFBI80I0 1731 BI4I 10551, 14961. 19371, 23781, norovirus Hu/GII.2/NF2002/USA/2002

28191, 326DI.37011

1732 VPI AFBI8DI3 1732 BI42 10552, 14962, 19372, 23782, norovirus Hu/GII.4/NF2003/USA/2003

28192.32602, 37012

1733 VPI AFJ05B24 1733 BI43 10553. 14963, 19373, 23783, norovirus dog/F053/2007/lta

28193, 32603.37013

1734 VPI AFJ05G28 1734 BI44 10554, 14964. 19374, 23784. noruvirus dog/FD2IO/2D07/lta

28194.32604, 37014

1735 VPI AFJ24945 1735 BI45 10555, I49B5, 19375, 23785. norovirus Hu/Gli-4/CBNU2/2DD7/ R

28195, 32B05, 37015

I73B VPI AFK7585I I73B BI4B I055B, I49BB, I937B, 2378B, norovirus Hu/GI.3/1999

28196, 3260B, 370IB

1737 VPI AFK75852 1737 BI47 10557. I49B7. 19377, 23787. norovirus Hu/GI.4/2000

28197, 32B07.37DI7

1738 VPI AF 75853 1738 BI48 ID558, 14968, 19378, 23788, norovirus Hu/GI.2/1999

28198, 32B08, 37018

1739 VPI AFK75854 1739 BI49 10559, 140Β9. 19379, 23789, norovirus Hu/GII.3/1989

28199, 32609, 37019 I74D VPI AFNBI3I5 I74B BI5B ID56B. I497D, I938B, 23790, norovirus Hu/BIV.I/AhrEnshoap24B/0E0/2BI2

2820D, 326ID. 37020

1741 VPI AFD005II 1741 GI5I 10561, 14971, 19381. 23791, norovirus Hu/GII.4/Xi'an/PI9/20IO/CHN

28201, 32611, 37021

1742 VPI AFQ005I2 1742 BI52 10562, 14972, 19382, 23792, narovirus Hu/Bll.4/Xi'an/P4B/20I0/CHN

28202, 32BI2, 37022

1743 VPI AFQDD5I3 1743 BI53 I05B3, 14973, 19383. 23793, norovirus Hu/GII.4/Xi'an/P49/20IO/CHN

28203, 32613.37023

1744 VPI AFQ005I6 1744 BI54 10564. 14974, 19384, 23794, norovirus Hu/GII.4/Xi'an/PI43/20IO/CHN

28204, 32614, 37024

1745 VPI AFBBB5I7 1745 BI55 10565, 14975, 19385, 23705, norovirus Hu/GII.4/Xi an/PI52/20IO/CHN

28205. 32615, 37025

1746 VPI AF0BB5I8 I74B BI5B 10566, 14976, 19386, 23796, norovirus Hu/GII.4/Xi'an/PI54/2OI0/CHN

28206, 32616, 37026

1747 VPI AFBBB5I9 1747 BI57 10567, 14977, 19387, 23797, norovirus Hu/GII.4/Xi'an/PI58/20IO/CHN

28207, 32617, 37027

1748 VPI AFQBB52D 1748 BI58 10568, 14978, 19388, 23798, norovirus Hu/GII.4/Xi'an/PI85/2OI0/CHN

28208, 32618, 37028

1749 VPI AFBBB52I I74B BI59 10569, 14979, 19389, 23799, norovirus Hu/GII.4/Xi'an/CG/Z0IO/CHN

28209, 32BI9, 37029

I75D VPI AFQD0522 I75B BIBB I057D, 14980, 19390, 23800, norovirus Hu/GII.4/Xi'an/CI2/20ID/CHN

28210, 32620, 37030

1751 VPI AFQDD523 1751 BIBI 10571, 14981, 19391, 23801, norovirus Hu/GII.4/Xi'an/CI5/2DID/CHN

28211, 32621, 37031

1752 VPI AFBD0524 1752 6162 10572, 14982, 19392, 23802, norovirus Hu/Gll.4/Xi'an/C2l/20I0/CHN

28212, 32622.37032

1753 VPI AFBGD525 1753 BIBS 10573, 14983, 19393, 23803, norovirus Hu/GII.4/Xi'an/C3D/20ID/CHN

28213, 32623, 37033

1754 VPI AFBDD52B 1754 BIB4 10574, 14984, 19394, 23804, norovirus Hu/GII.4/Xi'an/C3l/2DI0/CHN

28214, 32624, 37034

1755 VPI AFQDD527 1755 6165 10575, 14985, 19395, 23805, norovirus Hu/GII.4/Xi'an/C4l/20IO/CHN

28215, 32625, 37035

I75B VPI AFQD0528 I75B 6166 10576, 14986, 19396, 23806, norovirus Hu/GII.4/Xi ^* an/C45/2DI0/CHN

28216, 32626. 37036 1757 VPI AGCBB782 1757 6167 ID577. 14987, 19397. 238D7, norovirus Hu/GII.6/GZ20IO- 28217, 32627, 37037 Li/Guangzhou/CHN/2010

1758 VPt AGCBB784 1758 6IB8 10578, 14988, 19398, 23808, norovirus Hu/GII.4/GZ20IO- 28218, 32628, 37038 L32/Guangzhou/CHN/20IO

I75B VPI AGCBB785 1759 6IB9 10579, 14989, 19399, 23809, norovirus Hu/GII.3/GZ20IO- 28219, 32629, 37039 LG3/Guangzhou/CHN/20IO

I7B0 PI AGCBB78B I7BD BI7D 10580, 14990, 19400, 23810, norovirus Hu/GII.B/GZ20IO- 28220, 32630, 37Q40 L72/Guangzhou/CHN/20IO

I7BI VPI AGCBB788 I7BI 6171 10581. 14991, 19401. 23811, norovirus Hu/GII.4/GZ20IO- 28221, 32631, 37041 LBS/Guangzhou/CHN/ZDIf

1762 VPI AGLBB587 I7B2 6172 10582, 14992, 19402, 23812, norovirus Hu/Gll/Hy-7I8/K0R

28222, 32B32, 37042

I7B3 VPI AGO57036 I7B3 6173 10583. 14993, 19403, 23813, norovirus Hu/GII.7/VLP 05G954/2005/DE

28223, 32633.37043

I7B4 VPI AGT9592B I7B4 6174 10584. 14994. 19404, 23814, norovirus Hu/GH.4/ variant Sydney 2012/FRA

28224, 32634, 37044

I7B5 VPI AGTB5327 1765 6175 10585, 14995, 19405, 23815, norovirus Hu/GII.4/ variant Sydney 2012/FRA

28225, 32635, 37045

I7BB VPI AGT95928 I7B6 6176 I058B, 14996, 19406, 23816, norovirus Hu/GII.4/variant Sydney 2012/FRA

2822B, 32B3B, 3704B

I7B7 VPI AGT95929 1767 6177 10587, 14907. 19407, 23817, norovirus Hu/GII.4/variant Sydney 2012/FRA

28227, 32637, 37047

I7B8 VPI AGT95930 1768 6178 10588, 14998. 19408, 23818. norovirus Hu/GII.4/ variant Sydney 2012/FRA

28228, 32638, 37048

I7B9 PI AGT9593I 1769 6179 10589, 14999, I940B, 23819, norovirus Hu/GII.4/ ariant Sydney 2012/FRA

28229, 32639, 37049

I77D VPI AHCI2B55 I77D 6186 10590, 15000, 19410, 23820. norovirus Hu/GII.4/PA3B3/20ll/ITA

28230, 32640, 37050

1771 VPI AHCI2B58 1771 6181 10591, 15001, 19411. 23821, norovirus Hu/Gll.4/PA48/20I2/ITA

28231, 32641, 37051

1772 VPI AHW99832 1772 6182 10592, 15002, 19412, 23822, norovirus Hu/GI.5/Siklos-H0N5407/20l3/H0N

28232, 32642, 37052

1773 VPI AHZI2735 1773 6183 10593, 15003, 19413. 23823, norovirus GII.3

28233, 32B43, 37053 1774 VPI AHZI273B 1774 BI84 10594, 15004, 19414, 23824, noravirus EH 11.3

28234, 32644, 37054

1775 VPI AHZI2737 1775 BI85 10595, 15005, 19415, 23825, narDvirus Gil.3

28235, 32645, 37055

I77G VPI AHZI2738 I77B BI8B 10596, I5DD6, 19416, 2382B, nDTDvirus Gil .3

28236, 32646, 37056

1777 VPi AHZI2739 1777 BI87 10597, 15007, 19417, 23827, noravirus GII.3

28237, 32647, 37057

1778 VPI AHZI29I2 1778 BI88 10598, 15008, 19418, 23828, noravirus

28238, 32648, 37058 Hu/GII.4/P3/20l2/GDthenburg/Sweden

1778 VPI AHZI29I3 1779 6189 10599. 15009, 19419, 23829, noravirus

28238, 32649, 37059 Hu/GII.4/P4/20l2/GDthenburg/Sweden

1780 VPI AHZI2998 I78D BI9D 10600, 15010, I942D, 23830, noravirus

28240, 32650, 37060 Hu/GII.4/P54/20l2/Goth _E nburg/SwedBn

1781 VPI AHZI300I 1781 BI9I 10601, 15011, 19421, 23831, noravirus

28241, 32651, 37061 Hu/GII.4/P55/20l2/Gothenburg/SwedBn

1782 VPI AHZI3Q04 1782 BI92 10602, 15012, 19422, 23832, noravirus

28242, 32652.37062 Hu/Gil.4/P56/20l2/GothBnburg/SwBdBn

1783 VPI AHZI30I0 1783 6193 I0B03. 15013, 19423, 23833, noravirus

28243, 32B53, 370B3 Hu/GII.4/P58/20l2/GathBnburg/SwedBn

1784 VPI AHZI3DI5 1784 BI94 10604. 15014, 19424, 23834, noravirus

28244, 32654, 37DB4 Hu/GII.4/P60/20l2/Gothenburg/SwedBn

1785 VPI AHZI3D2D 1785 6195 10605, 15015, 19425, 23835, noravirus

28245, 32655, 37065 Hu/GII.4/P62/20l2/GathBnburg/SwBdBn

I78G VPI AHZI3D23 I78B 6196 10606, 15016, 19426, 23836, noravirus

28246, 32656, 37066 Hu/GII.4/P63/20l2/Gathenburg/SwEdBn

1787 VPI AIC32559 1787 6197 10607, 15017, 19427, 23837, nDPovipus Hu/GI /TangEr TMBB7/201l/MAR

28247, 32657, 37067

1788 VPI AID5I474 1788 6198 I0BD8, 15018, 19428, 23838, noravirus I2-AA-I/20I2/GII.P22/GII.5

28248, 32658, 370G8

1789 VPI AID5I477 1789 6199 I0G09, 15019, 19429, 23839, noravirus I2-C-I/20I2/GII.P22/GII.5

2824B, 32659, 37069

I79D VPI AID5I480 1790 B200 10610, 15020, 19430, 23840, noravirus I2-E-I/20I2/GII.P22/GII.5

28250, 32660, 37070 I8D8 VPI ALQ44I24 1808 B2IB 10628, 15038. 13448. 23858, norovirus GIIJ7

282B8, 32B78, 37088

1808 VPI ALQ44I25 1809 6219 10623, 1503B, 13443, 23859, norovirus GII.I7

2826B.32679.37089

1810 VPI BAB835I4 1810 B220 I0B30, 1504D, I345B, 2386D, swine norovirus

28270.32680, 37D90

181! VPI BAB835I6 1811 6221 10631, 15041, 19451, 23861, SWIPE norovirus

28271, 32681, 37091

1812 VPI BAD727B7 1812 6222 10632, 15042, 19452, 23862, norovirus Hu/GII/lna/02/JP

28272, 32682, 37092

1813 VPI BAD72798 1813 B223 10633, 15043, 19453, 23863, norovirus Hu/BII/Sinsiro/97/JP

28273, 32683, 37093

1814 VPI BAD7279B 1814 B224 I0B34, 15044. 13454. 23864, norovirus Hu/GII/Hakushin/03/JP

28274, 32684, 37094

1815 VPI BAD728Q0 1815 6225 I0B35, 15045, 13455, 23865, norovirus Hu/GII/ amo/03/JP

28275, 32685, 37035

1816 VPI BAD88558 1816 6226 10636, 15046, 13456, 238B6, norovirus Hu/OC02202/2002/JP

2827B, 3268B, 37036

1817 VPI BAD98240 1817 6227 10637, 15047, 13457, 23867, norovirus Hu/Hokkaido/133/2003/JP

28277, 32B87, 37097

1818 VPI BAE43833 1818 6228 10638, 15048, 19458, 23868, norovirus Hu/GI/OtofukE/1979/JP

28278, 32B88, 37098

1819 VPI BAE48588 1819 6223 10639, 15049, 19459, 23863, norovirus Hu/Saga/5424/03/JP

28273, 32683, 37093

1820 VPI BAE4858B 1820 6230 10640, 15050, 1946D, 23870, norovirus Hu/Maizuru/5017/04/JP

28280, 32690, 37100

1821 VPI BAE48590 1821 6231 10641. 15051. 19461, 23871, norovirus Hu/78/04/Ru

28281, 32691, 37101

1822 VPI BAE92970 1822 6232 I0B42, 15052, I94B2, 23872, norovirus swina/KS/JP

28282, 32B92, 37102

1823 VPI BAE98I9I 1823 6233 I0B43, 15053, 19463, 23873, norovirus Hu/Chiba/04-l050/20D5/JP

28283, 32B33, 37IB3

1824 VPI BAE98IB4 1824 6234 I0B44, 15054, 13464, 23874, norovirus Hu/Sakai/04-l79/20Q5/JP

28284, 32634, 37104 1825 VPI 8AE38I37 1825 B235 IBB45, 15055, 13465, 23875, norovirus Hu/Ehime/05-30/2005/JP

28285, 32635, 37105

1826 VP1 BAF4586I I82B B23B I064B, 15056, 13466, 23876, norovirus Hu/GII.4/KobeD34/2Q06/JP

28286, 326B6. 37106

1827 VPI BAF745B8 1827 B237 I0B47, 15057, 13467, 23877, norovirus Hu/GBII.4/TiElOOI/l995/NL

28287, 32637, 37107

1828 VPI BAF745B9 1828 6238 10648, 15058, 13468, 23878, norovirus Hu/GGII.4/DenHaagOI5/2000/NL

28288, 32638.37ID8

1823 VPI BAF745I0 1823 6233 10643, 15053. 13463, 23873, norovirus

28289, 32693, 37103 Hu/GGII.4/WaddinxvEenOI6/2000/NL

1830 VPI BAF745II 1830 6240 10650, 15060, 13470, 23880, norovirus

2823D, 32700. 37110 Hu/GGII.4/LBBuwarden043/2000/NL

1831 VPI BAF745I2 1831 6241 10651, I50BI, 13471, 23881, norovirus Hu/GGII.4/SchiedamOI8/200l/NL

28231, 32701, 37111

1832 VPI BAF745I3 1832 6242 I0B52, 15062, 13472, 23882, norovirus Hu/GGII.4/UtrechtD58/200l/NL

28232.32702, 37112

1833 VPI BAF745I4 1833 6243 10653, 15063, 13473, 23883, norovirus Hu/GGII.4/WeertED22/Z002/NL

28233, 32703, 37113

1834 VPI BAF745I5 1834 6244 10654, 15064, 13474, 23884, norovirus Hu/GGII.4/EmmenE006/2002/NL

28234, 32704, 37114

1835 VPI BAF745IB 1835 B245 I0B55, 150B5. 13475, 23885, norovirus Hu/BGII.4/HeerlenOD3/Z003/NL

28235, 32705, 37115

1836 VPI BAF745I7 1836 B24B I0B5B, I506B, I347B, 2388B, norovirus Hu/GGII.4/Apeldoorn023/2003/NL

28236, 3270B. 37116

1837 VPI BAF745I8 1837 6247 IQ657, 15067, 19477, 23887, norovirus Hu/GGII.4/DBnHa8g00l/2003/NL

28237, 32707, 37117

1838 VPI BAF745I3 1838 6248 I0B58, 150B8, 13478, 23888, norovirus Hu/GGII.4/Haarlem457/2003/NL

28298, 32708, 37118

1833 VPI BAF7452D 1833 6243 I0B59. 15063, 13479, 23889, norovirus Hu/GGll.4/DBnHBldBr003/2004/NL

28293, 32703, 37113

1840 VPI BAF7452I I84B 6253 I0B60. 15070, 13480, 23890, norovirus Hu/GGII.4/MiddelburgQ07/2D04/NL

28300, 32710, 37120

1841 VPI BAF74522 1841 B25I 10661. 15071, 19481, 23891, norovirus Hu/GGI1.4/ElslooOI2/20D4/NL

28301, 32711, 37121 1842 VPI BAF74523 1842 B252 I0BB2, 15072. 19482, 23892, narovirus Hu/BGII.4/0enBasch0Z8/2DD4/NL

28302, 32712, 37122

1843 VPI BAF74524 1843 B253 IDBB3, 15073, 19483, 23893, norovirus Hu/GGII.4/Almelo03B/2004/NL

28303, 32713, 37123

1844 VPI BAF74525 1844 B254 I0BB4, 15074, 19484, 23894, narovirus Hu/GGII.4/LiBmpdED48/Z0D4/NL

28304, 32714, 37124

1845 VPI BAF7452B 1845 B255 I0BB5, 15075, 19485, 23895, norovirus Hu/GGII.4/TilbupgD59/2004/NL

28305, 32715, 37125

I84G VPI BAF74527 I84B B25B IOBBB, I507B, I948B, 2389B, nnrovirus Hu/GGII.4/Nijmegen083/2004/NL

2830B, 327IB, 37I2B

1847 VPI BAF85490 1847 B257 I0BB7, 15077, 19487, 23897, norovirus Hu/GII-4/Matsudo/02l07l/2002/JP

28307, 32717, 37127

1848 PI BAF9550I 1848 B258 I0BB8, 15078, 19488, 23898, norovirus Hu/GII-4/ aiso/03055B/2003/JP

28308, 32718, 37128

1849 VPI BAF95503 1849 B259 I0BB9, 15079, 19489, 23899, norovirus Hu/GII-4/Chiba/040095/20D3/JP

28309, 32719, 37129

1850 VPI BAF955D5 1850 B2BD I0B70, 15080, 19490, 23900, norovirus Hu/GII-4/Awa/040354/2004/JP

28310, 32720, 37130

1851 VPI BAF95507 1851 B2BI I0B7I, 15081, 19491, 23901, norovirus Hu/GII-4/Chiba/040974/2004/JP

28311, 32721, 37131

1852 VPI BAF955D9 1852 B2B2 I0B72, 15082. 10492, 23902, norovirus Hu/GII-4/ atori/D4l008/2004/JP

28312, 32722, 37132

1853 VPI BAF955II 1853 B2B3 I0B73, 15083, 194B3, 23903, norovirus Hu/GII-4/ imitsu/04l440/2005/JP

28313, 32723, 37133

1854 VPI BAF955I3 1854 B2B4 I0B74, 15084, 19494, 23904, norovirus Hu/GII-4/lnba/05059D/2005/JP

28314, 32724, 37134

1855 VPI BAF955I5 1855 B2B5 I0B75, 15085, 1940S, 23905, norovirus Hu/GII- 28315, 32725, 37135 4/Funabashi/050B0l/2005/JP

1856 VPI BAF955I7 I85B B2BB I0B7B, I508B, I949B, 2390B, norovirus Hu/GII- 283IB, 3272B, 37I3B 4/lchikawa/05070l/2005/JP

1857 VPI BAF955I9 1857 B2B7 I0B77, 15087, 19497, 23907, norovirus Hu/GII-4/Sanbu/050878/200B/JP

28317, 32727, 37137

1858 VPI BAF9552I 1858 B2B8 I0B78, 15088, 19498, 23908, norovirus Hu/GII- 28318, 32728, 37138 4/ ashiwa/0B08D2/200B/JP 1859 VPI BAF95523 1859 62G9 10670, 15080, 10400, 23909, narovirus Hu/GII-4/lsumi/0B0936/Z00B/JP

28319, 32729, 37139

I860 VPI BAF95525 I860 6270 10680, 15090, 10500, 23010, norovirus Hu/GII-4/lnba/0BIDB9/200B/JP

28320, 32730, 37140

1861 VPI BAF95527 1861 B27I 10681. 15001, 19501. 23911, norovirus Hu/GII-4/Kimitsu/06H46/2006/JP

28321, 32731, 37141

1862 VPI BAF95529 1862 6272 10682, 15002, 10502, 23012, norovirus Hu/GII- 28322, 32732, 37142 4/Kashiwa/06l256/2Q06/JP

1863 VPI BAF9553I 1863 6273 10683, 15093, 19503, 23913, norovirus Hu/GII- 28323, 32733.37143 4/Narashino/06l28l/2006/JP

1864 VPI BAG3D923 1864 6274 I0B84, 15004, 19504, 23914, norovirus Hu/0C07l38/07/JP

28324, 32734.37144

1865 VPI BAG3463D 1865 6275 I0B85. 15095, 10505. 23915. norovirus Hu/0C07049/l997/JP

28325, 32735, 37145

1866 VPI BAG34632 1866 6276 I068B, I509B, 10506. 239IB, norovirus Hu/OCOI243/200l/JP

2832B, 32736.37146

1867 VPI BAG34634 1867 B277 10687, 15097, 10507, 23017, norovirus Hu/0C020l2/2002/JP

28327, 32737, 37147

1868 VPI BAG34G36 1868 B278 10688, I5D98. 10508, 23018, norovirus Hu/0C02022/2002/JP

28328, 32738, 37148

1869 VPI BAG34638 1869 B279 10689, 15099. 19500. 23910. norovirus Hu/0C04038/2004/JP

28320, 32739, 37140

I87D VPI BAG3464D 1870 B28D 10690, 15100, 19510, 23020, norovirus Hu/0C04042/2004/JP

28330, 32740, 37150

1871 VPI BAG34642 1871 6281 10601, 15101, 19511. 23921, norovirus Hu/OC04043/2004/JP

28331, 32741, 37151

1872 VPI BAG34644 1872 6282 10602. 15102. 19512, 23022, norovirus Hu/OC0405B-l/2004/JP

28332, 32742, 37152

1873 VPI BAG34B4B 1873 G283 I0B93, 15103, 19513, 23923, norovirus Hu/0CQ4056-2/2004/JP

28333, 32743, 37153

1874 VPI BAG34B48 1874 6284 10604, 15104, 19514, 23924, norovirus Hu/OC04059/2004/JP

28334, 32744, 37154

1875 VPI BAG34G5Q 1875 6285 10695, 15105, 19515, 23925, norovirus Hu/OC04067/2004/JP

28335, 32745, 37155 I87G VPI BAG34652 I87B G28B IQB96, I5IQB, I95IB. 23926. norovirus Hu/0C0407l/2004/JP

2833B, 3274B, 37I5B

I877 VPI BAG34654 I877 B287 I0B97, I5I07. I95I7, 23927, norovirus Hu/DC04073/2004/JP

28337, 32747, 37I57

I878 VPI BAG34B5B I878 G288 I0B98, I5IQ8, 19518. 23928, naravirus Hu/OC04075/2D04/JP

28338, 32748, 37158

I878 VPI BAG34B58 I879 6283 10699. 15109, 19510, 23929, norovirus Hu/0C04076/2004/JP

28339, 32749. 37159

I88D VPI BAG34BB2 I88D B29B 10700. 15110. I952D. 23930, norovirus Hu/OC05QID/2005/JP

28340, 32750. 37IBD

I88I VPI BAG34GB4 I88I B29I 10701. I5III, 19521, 23931. norovirus Hu/0CSD2D289/2002/JP

28341, 32751.37161

I882 VPI BAG34BBB I882 B2B2 10702, 15112, 19522, 23932, norovirus Hu/0CS030697/2D04/JP

28342. 32752, 37162

I883 VPI BAG34BB8 I883 G2B3 10703, 15113, 19523, 23933, norovirus Hu/0CS040035/2004/JP

28343, 32753, 37163

I884 VPI BAG34B7D I884 B294 10704, 15114, 19524. 23934, norovirus Hu/OCS040IOO/2004/JP

28344. 32754, 37164

I885 VPI BAG55289 I885 6295 10705, 15115, 19525, 23935, norovirus Hu/GII.4/Apeldoorn3l7/2007/NL

28345, 32755, 37IB5

I88B VPI BAGB87D7 I88B 6296 10706, I5IIB, 19526, 23936, norovirus Hu/GII.2/CoBvordenl9IS/l999/NL

28346, 3275B, 37166

I887 VPI BAGB8708 I887 6297 10707, 15117, 19527, 23937, norovirus Hu/GII.2/DenHaag37/2000/Nl

28347, 32757, 37167

I888 VPI BAGB870B I888 6298 10708, 15118, 19528, 23938, norovirus Hu/GII.2/Delft48M/2000/NL

28348, 32758, 37IB8

I88B VPI BAGB87II I889 6299 10709, 15119, 19529, 23939, norovirus Hu/GII.2/Zwolle25E/200l/NL

28349, 32759, 37169

I89D VPI BAGG87I2 I83D 63BB 10710. 15120. 19530. 23940, norovirus Hu/GII.2/Heerlen7E/2D02/NL

28350, 32760, 37170

isei VPI BAGB87I3 I89I 63BI 10711. 15121. 19531. 23941, norovirus Hu/GII.2/Rotterdam39E/2002/NL

28351, 32761, 37171

I882 VPI BAGB87I4 I892 6302 10712, 15122, 19532, 23942, norovirus Hu/GII.2/leeuwardEn7l/2Q03/NL

28352, 32762, 37172 1893 VPI BAB687I5 1893 6303 10713, 15123, 13533, 23943, noravirus Hu/BII.2/Boes28/2D05/NL

28353, 32763, 37173

1894 VPI BAG687I6 1894 6304 10714, 15124, 19534, 23944, noravirus Hu/GII.2/Vaals87/2005/NL

28354, 32764, 37174

1895 VPI BABB8799 1895 6305 10715, 15125, 19535, 23945, noravirus Hu/GII.3/RotterdamPID0/200G/NL

28355, 32765, 37175

1896 VPI BABG8800 I89B B306 10716, 15126, 19536, 23946, noravirus

28356, 32766, 37176 Hu/GII.3/RotterdamPID88/200G/NL

1897 VPI BABB880I 1897 B307 10717, 15127, 19537, 23947, noravirus Hu/Gll.4/RDtterdamPZDO/2005/NL

28357, 32767, 37177

1898 VPI BABB8802 1898 B308 10718, 15128, 19538, 23948, noravirus

28358, 32768, 37178 Hu/GII.4/RotterdamP2DI82/2005/NL

1899 VPI BABB8803 1899 B309 10719. 15129, 19539, 23949, noravirus Hu/GII.4/RotterdamP3D0/2006/NL

28359, 32769, 37179

1900 VPI BABB8804 1900 6310 10720, 15130, 19540, 23950, norovirus Hu/GII.4/RottErdamP3D2l/2006/NL

283B0.32770, 37180

1901 PI BAGB8805 1901 6311 10721, 15131. 19541, 23951, noravirus Hu/Bli.4/RotterdamP4DD/2D0B/NL

283BI.32771, 37181

1902 VPI BAGB8806 1902 6312 10722, 15132, 19542, 23952, noravirus

28362, 32772, 37182 Hu/GII.4/RottErdamP4D33/200G/NL

1903 VPI BAGB8807 1903 6313 10723, 15133, 19543, 23953, noravirus Hu/GII,3/RotterdamP5D0/2005/NL

28363, 32773, 37183

1904 VPI BAGB8808 1904 6314 10724, 15134, 19544, 23954, noravirus

28364, 32774, 37184 Hu/GII.4/RottErdamP5D36/2005/NL

1905 VPI BAGB8809 1905 6315 10725, 15135, 19545, 23955, noravirus Hu/GII.4/RotterdamP5D5l/2005/NL

28365, 32775, 37185

1906 VPI BAGB88I0 I90B 6316 10726, 15136, 19546, 23956, noravirus Hu/GII.4/RotterdamP6D0/2D06/NL

28366, 32776, 37I8B

1907 VPI BAGB881I 1907 6317 10727, 15137, 19547, 23957, noravirus

283B7, 32777. 37187 Hu/GII.4/RottBrdamP6D33/200B/NL

1BD8 VPI BAGB88I2 1908 B3I8 10728, 15138. 19548. 23958, noravirus Hu/GII.4/RottErdamP7D0/200B/NL

28368. 32778, 37188

1909 VPI BAGB88I3 1909 6319 10729, 15139, 19549, 23959, noravirus

28369, 32779, 37189 Hu/GII.4/RDtterdamP7DII9/2007/NL 1910 VPI BAGG88I4 1910 B320 10730, 15140, 19550, 239B0, norovirus Hu/GII.3/RotterdamP8D0/200G/NL

28370, 32780, 37190

1911 VPI BAGG88I5 1911 G32I 10731, 15141, 19551, 239BI, norovirus

28371, 32781, 37191 Hu/GII.3/RotterdamP8D3l/2006/NL

1912 VPI BAG688IG 1912 B322 10732, 15142, 19552, 23962, norovirus

28372, 32782, 37192 Hu/GII.4/RotterdamP8D65/2006/NL

1913 PI BAH04374 1913 B323 10733, 15143, 19553, 23963, murine norovirus

28373, 32783, 37193

1914 VPI BAH04377 1914 B324 10734, 15144, 19554, 23964, murine norovirus

28374, 32784, 37194

1915 VPI BAH2978B 1915 B325 10735, 15145, 19555, 239B5, norovirus Hu/0C08086/08/JP

28375, 32785.37195

I91G VPI BAH30707 1916 B32B I073B, 15146, I955B, 23966, norovirus

28376, 32786, 37I9B Hu/Gll.4/Stockholm/I98G5/2008/SE

1917 VPI BAL408B9 1917 B327 10737, 15147, 19557, 23967, norovirus Hu/GII.B/0CD8025VLP/2008/JP

28377, 32787, 37197

1918 VPI BAL40870 1918 B328 10738, 15148, 19558, 23968, norovirus Hu/GII.6/0H090l4VLP/2009/JP

28378.32788, 37198

1919 VPI BAL4087I 1919 B329 10739, 15149, 19559, 23969, norovirus Hu/GII.6/0C090l5VLP/2D09/JP

28379, 32789, 37199

1920 VPI BAL40872 1920 B330 10740, 15150, 19560. 23970. norovirus Hu/GII.6/0H050l0VLP/2005/JP

28380.32790, 37200

1921 VPI BAL40873 1921 B33I 10741, 15151, 19561, 23971, norovirus Hu/GII.G/0C04062VLP/2004/JP

28381, 32791, 372DI

1922 VPI BALB0900 1922 B332 10742, 15152, 19562, 23972, murine norovirus

28382, 32792, 37202

1923 VPI BAB552II 1923 B333 ID743, 15153, 19563, 23973, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28383, 32793, 37203 inpatient6-26d

1924 VPI BAQ552I2 1924 B334 10744, 15154, 19564, 23974. norovirus Hu/JP/2004/GII.4/Sakai/0l- 28384.32794.37204 inpatient8-ld

1925 VPI BAQ552I3 1925 B335 10745, 15155, I95B5, 23975, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28385, 32795.37205 inpatient8-29d-l

192G VPI BA0552I4 I92B B33B I074B, 15156, 19566, 23976. norovirus Hu/JP/2004/GII.4/Sakai/0l- 28386, 32796, 37206 inpatient8-29d-2 1927 VPI BAQ552I5 1927 B337 10747, 15157, I95B7, 23977, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28387, 32797, 37207 inpatient8-29d-3

1928 VPI BA0552I6 1928 B338 10748. 15158, I95B8, 23978, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28388, 32798, 37208 inpatient8-29d-4

1929 VPI BAQ552I7 1929 B339 10749, 15159, 19569, 23979, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28389, 32799, 37209 inpat(Bnt8-54d-l

1930 VP! BAQ552I8 1930 B34D 10750, 15160, 19570, 23980, norovirus Hu/JP/2004/GII.4/Sakai/0l- 28390, 32800, 37210 inpatient8-54d-2

1931 VPI BA 4739B 1931 B34I 10751, I5IBI. 19571, 23981, norovirus GII/Hu/JP/2007/GII.4/y0B-VII0-5

28391, 32801, 37211

1932 VP! BAR47397 1932 B342 10752, 15162, 19572, 23982, norovirus GII/Hu/JP/2008/GII.4/y07-VI79-l

28392, 32802, 37212

1933 VPI BAR47398 1933 B343 10753, 15163. 19573, 23983, norovirus GII/Hu/JP/2008/GII.4/y07-V203-l

28393, 32803, 37213

1934 VPI BAR474DD 1934 B344 10754, 15164, 19574, 23984, norovirus GII/Hu/JP/2008/GII.4/y08-V290-2

28394, 328D4, 37214

1935 VPI BAR474DI 1935 B345 10755, 15165, 19575, 23985, norovirus GII/Hu/JP/2009/GII.4/y08-238-2

28395, 32805, 37215

1936 VPI BAR474B3 I93B B34B 10756, I5IB6, 19576, 23986, norovirus GII/Hu/JP/20IO/GII.4/y09-205-l

28396, 32806, 372IB

1937 VPI BAR474B4 1937 B347 10757, 15167. 19577, 23987. norovirus GII/Hu/JP/20IO/GII.4/ylO-V475-l

28397, 32807, 37217

1938 VPI BAR474B5 1938 B348 10758, 15168, 19578, 23988, norovirus GII/Hu/JP/20ll/GII.4/ylO-V52B-8

28398, 32808, 37218

1939 VPI BAR474DB 1939 B349 10759, 15169, 19579, 23989, norovirus GII/Hu/JP/20ll/GII.4/yll-l88-l

28399, 32809, 37219

I94D VPI BAR474B7 1940 B350 I07B0, 15170, 19580, 23990, norovirus GII/Hu/JP/20l2/GII.4/yll-VB64-l

28400, 32810, 37220

1941 VPI BAR474D8 1941 B35I 10761, 15171, 19581, 23991, norovirus GII/Hu/JP/20l2/GII.4/yll-V689-2

28401, 32811, 37221

1942 VPI BAR474ID 1942 B352 I07B2, 15172, 19582, 23992, norovirus GII/Hu/JP/20l2/GII.4/yl2-V836-3

28402, 32812, 37222

1943 VPI BAR474I2 1943 B353 I07B3, 15173, 19583, 23993, norovirus GII/Hu/JP/20ll/GII.4/yll-V627-3

284D3, 32813, 37223 1044 VPI BAR474I3 1944 B354 I07B4, 15174. 19584. 23994, naravirus BII/Hu/JP/20ll/GII.4/yll-VB33-3

284B4, 32814, 37224

1945 VPI BAR474I4 1945 B355 ID7B5, 15175, 19585, 23995, noPDvirus GII/Hu/JP/20ll/GII.4/yll-V645-Z7

284B5.32815, 37225

I94B VP! BAR474I5 I94B B35B ID7BB, 15176. I958B, 2399B, noravirus GII/Hu/JP/2D11/G!i.4/ylf-VB4S-l

284BB, 328IB, 3722B

1947 VPI BAR474I7 1947 B357 ID7B7, 15177, 19587, 23997, norovirus GH/Hu/JP/2D12/GII.4/yl2-V7B2-f

284B7, 32817, 37227

1948 VPI BAR474I8 1948 B358 IB7B8, 15178, 19588, 23998, noravirus GII/Hu/JP/20l2/GII.4/yl2-V780-l

28408, 32818, 37228

1949 VPI BAR4742I 1949 B359 I07B9, 15179. 19589. 23999. noravirus GII/Hu/JP/20l3/GII.4/yl2-V849-2

284D9.32819. 37229

I95D VPI BAR47422 I95D B3BG ID770, 15180, 19590, 24000, norovirus GII/Hu/JP/20l3/GII.4/yl3-l40-l

28410, 3282D, 37230

1951 PI BAR47423 1951 B3BI 10771, 15181, 19591, 24001, norovirus GII/Hu/JP/20l3/GII.4/yl3-V938-3

28411, 32821, 37231

1952 VPI BAR47424 1952 B3B2 10772, 15182, 19592, 24002, norovirus GII/Hu/JP/20l3/GII.4/yl3-IBB-l

28412, 32822, 37232

1953 VPI BAR4742B 1953 B3B3 10773, 15183, 19593, 24003, norovirus GII/Hu/JP/20l4/GII.4/yl3-VIOIO-l

28413, 32823, 37233

1954 VPI BAS5373I 1954 B3B4 10774, 15184, 19594, 24004, noravirus Hu/GII.4/Wakayama/TI58/20IO/JP

28414, 32824, 37234

1955 VPI BAS53732 1955 B3B5 10775, 15185, 19595, 24005, norovirus Hu/GII.4/Wakayama/TI62/20IO/JP

28415, 32825, 37235

I95B VPI BAS53733 I95B B3BB I077B, 15186. I959B, 2400B. noravirus Hu/GII.4/Wakayama/TIB4/20IO/JP

284IB. 3282B, 3723B

1957 VPI BAS53734 1957 B3B7 10777, 15187, 19597, 24007, noravirus Hu/GII.4/Wakayama/TI69/20IO/JP

28417, 32827, 37237

1958 VPI BAS53945 1958 B3B8 10778, 15188, 19598, 24008, norovirus Hu/GII.4/T272/clade 2006b

28418, 32828, 37238

1959 VPI CAK222BI 1959 B3B9 10779, 15189, 19599, 24009, noravirus Hu/GI/Babbacomb_/l996/GBR

28419, 32829, 37239

I9B0 VPI CAR9587G I9BB B370 10780, 15190, 19600. 24010, norovirus Hu/GIV.I/ltaly/980/2D07/ITA

28420, 32830.37240 1961 VPI ADB279I4 1961 6371 10781. 15191, 19601, 24011, norovirus Hu/GII.4/HSI94/2DD9/US

28421. 32831, 37241

1962 VPI ADI458D0 1962 6372 10782, 15192, 19602, 24012, norovirus Hu/GGII.4/Dijon/E3l65/2008/FRA

28422, 32832, 37242

1963 VPI ADI458I0 1963 6373 10783. 15193, 19603, 24013, norovirus Hu/GGI!.4/Dijan/E337B/20QS/FRA

28423, 32833, 37243

1964 VPI ADI458I3 1964 6374 10784, 15194, 19604, 24014, noravirus Hu/GGII.4/Dijan/E3550/2009/FRA

28424, 32834, 37244

1965 VPI ADT70684 1965 6375 10785. 15195, 19605, 24015, norovirus Hu/GII.I2/HS2IO/20IO/USA

28425, 32835, 37245

1966 VPI ADZ24DD3 1966 6376 10786, 15196, 19606. 24016. norovirus Hu/GII.I2/HS2D7/20IO/USA

28426, 32836, 37246

1967 VPI AFID8234 1967 6377 10787. 15197. 19607, 24017, norovirus Hu/GII/10002/2009/VNM

28427, 32837, 37247

1968 VPI AFID8237 1968 6378 10788, 15198, 19608, 24018, norovirus Hu/GII/l0003/2009/VNM

28428, 32838, 37248

1969 VPI AFID8243 1969 6379 10789, 15199, 19609, 24DI9, norovirus Hu/Gll/I0037/200B/VN

28429, 32839, 37249

1970 VPI AFJ385I6 1970 6380 I079D, 15200, 19610, 24020, norovirus HU/GI.I/8FIIB/I968/USA

28430, 32840, 37250

1971 VPI AFJ385I9 1971 B38I 10791, 15201, 19611, 24021, norovirus Hu/Gll.4/CH0C5I9I/I974/USA

28431, 32841, 37251

1972 VPI AFWI5937 1972 B382 10792, 15202, 19612, 24022, norovirus Hu/GII.4/N8/2DDB/HuZhou

28432, 32842, 37252

1973 VPI AFWI5939 1973 6383 10793, 15203, 19613, 24023, norovirus Hu/GII.4/N3/2008/HuZhou

28433, 32843, 37253

1974 VPI AFWI5942 1974 6384 10794, 15204, 19614, 24024, norovirus Hu/GII.4/NI3/2009/HuZhou

28434, 32844, 37254

1975 VPI AFWI5943 1975 6385 10795, 15205, 19615, 24025, norovirus Hu/GII.4/N76/2DID/HuZhou

28435, 32845, 37255

1976 VPI AFWI594G 1976 6386 10796, 15206, 19616. 2402B, norovirus Hu/GII.4/N9l 20ll/HuZhou

2843B, 32846, 37256

1977 VPI AFX7I656 1077 6387 10797, 15207, 19617. 24027. norovirus Hu/Gll.3/H 7I/I978/CHN

28437. 32847. 37257 1978 VPI AFX7I659 1978 B388 10798, 15208, 19618. 24028, norovirus Hu/Gll.2/KLI09/I978/MYS

28438, 32848, 37258

1979 VPI AFX8II24 1979 B389 10799, 15209, 19619, 24029, norovirus Hu/Norwalk/10051/2009/VNM

28439, 32849, 37259

1880 VPI AFX8II33 1980 B390 10800, 15210, 19620, 24030, norovirus Hu/Norwalk/10074/2009/VNM

28440, 32850, 372B0

1981 VPI AFX8II5I 1981 B39I 10801, 15211, 19621, 24031, norovirus Hu/Norwalk/IOII6/2Q09/VNM

28441, 32851, 372BI

1982 VPI AFX8IIB0 1982 B392 ID802, 15212, 19622, 24032, norovirus Hu/Norwalk/IOI37/20D9/VNM

28442, 32852, 37262

1983 VPI AFX8II75 1983 B393 10803, 15213, I9B23, 24033, norovirus Hu/Norwalk/10162/2009/VNM

28443, 32853, 37263

1984 VPI AFX8II84 1984 B334 10804, 15214, 19624, 24034, norovirus Hu/Norwalk/10173/2009/VNM

28444, 32854, 372B4

1985 VPI AFX8II87 1985 B395 10805, 15215, 19625, 24035, norovirus Hu/Norwalk/IOI7B/2009/VNM

28445, 32855, 372B5

I98B VPI AFX8I2I7 I98B B39B 10806, 15216, 19626, 24036, norovirus Hu/Norwalk/I0223/2009/VNM

28446, 32856.37266

1987 VPI AFX8I220 1987 B397 10807, 15217, 19627, 24037, norovirus Hu/Norwalk/I0235/2009/VNM

28447, 32857, 37267

1988 VPI AFX8I223 1988 6398 10808, 15218, I9B28, 24038, norovirus Hu/Norwalk/I023B/2009/VNM

28448, 32858, 37268

1989 VPI AFX8I235 1989 B399 10809, 15219, I9B29, 24039, norovirus Hu/Norwalk/10285/2010/VNM

28449, 32859, 372B9

1990 VPI AFX8I259 1990 B400 10810, 15220, I9B30, 24040. norovirus Hu/Norwalk/20008/2009/VNM

28450.32860, 37270

1991 VPI AFX8I280 1991 B40I 10811, 15221, 19631, 24041, norovirus Hu/Norwalk/20044/2009/VNM

28451, 328BI, 37271

1992 VPI AFX8I28B 1992 B402 10812, 15222, 19632, 24042, norovirus Hu/Norwalk/20066/2009/VNM

28452, 32862, 37272

1993 VPI AFX8I3I0 1993 B403 10813, 15223, 19633, 24043, norovirus Hu/Norwalk/20123/2009/VNM

28453, 328B3.37273

1994 VPI AGE894B9 1994 B404 10814, 15224, I9B34, 24044, norovirus Hu/Gll/20I44/2D09/VNM

28454, 328B4, 37274 1995 VPI AGE89484 1995 6405 10815, 15225, 19635, 24045, norovirus Hu/GII/20154/2009/VNM

28455, 32865, 37275

1996 PI AGE89487 1996 6406 10816, 15226, 19636, 24046, norovirus Hu/GII/20156/2009/VNM

28456, 32866, 37276

1997 VPI AGE89GI9 1997 6407 10817. 15227, IB637, 24047, narovirus Hu/GII/20460/2010/VNM

28457, 32867, 37277

1998 VPI AGE89G70 1998 6408 10818, 15228, 19638, 24048, noruvirus Hu/GII/30257/2009/VNM

28458, 32868, 37278

1999 VPI AGE9959B 1999 6409 10819, 15229, 19639, 24049, norovirus Hu/GII.4/NIHIC4.2/20ll/USA

28459, 32869, 37279

ZODD VPI AGE99599 2000 6410 10820, 15230, 19640, 24050, norovirus Hu/Gll.6/S9c/I976/SEN

28460, 32870, 37280

2DDI VPI AGE99GI2 2D0I 6411 10821, 15231, 19641, 24051, norovirus Hu/Gll.4/ L45/I978/MYS

28461, 32871, 37281

2002 VPI AGII7G09 2002 6412 10822, 15232, 19642, 24052, norovirus Hu/Gll.3/HK46/I977/CHN

28462, 32872, 37282

2003 VPI AGM332II 2003 6413 10823. 15233, 19643, 24053, norovirus

28463, 32873, 37283 Hu/GI.I/CHA6A003_2009l03l/2009/0SA

2004 VPI AGM33223 2004 6414 10824, 15234, 19644, 24054, norovirus

28464, 32874, 37284 Hu/Gl.l/CHA9A004_20II04I9/20II/0SA

20D5 VPI AGTI7839 2005 6415 10825, 15235, 19645, 24055, norovirus Hu/GII.4/NIHICI7.5/ZDIZ/USA

28465, 32875, 37285

200B VPI AGX859I0 2006 6416 10826, 15236, 19646, 24056, norovirus Hu/Gll.4/NIHICI.I6/20I2/USA

28466, 32876, 37286

2007 VPI AHI59IG2 2007 6417 I08Z7, 15237, 19647, 24057, norovirus Hu/GII.4/HS288/20l2/USA

28467, 32877, 37287

2008 VPI AHI59IB5 2008 6418 10828, 15238, 19648, 24058. norovirus Hu/GII.4/HS66/200l/USA

28468, 32878, 37288

2009 VPI AHX22044 2009 6419 10829, 15239, 19649, 24059, norovirus Hu/Gll/BGIC03I7/20II/BGD

28469, 32879, 37289

2010 VPI AII02587 2010 6420 10830, 15240, 19650, 24060, norovirus Hu/Gll/C2H-I8/20II/VNM

28470, 32880, 37290

2011 VPI AII02BI7 2011 6421 10831, 15241, 19651, 24061. norovirus Hu/GII/20419/2010/VN

28471. 32881.37291 2012 VPI AIS24556 2012 B422 10832, 15242, I3B52, 240B2, noravirus Gil

28472, 32882, 37232

2013 VP! BAI49B08 2013 B423 10833, 15243, 13B53, 240B3, narovirus Hu/GII.4/Hiposhima/55/2DD5/JPN

28473, 32883, 37233

2DI4 VPI BAI4BBI3 2014 B424 10834, 15244, I9B54, 240B4, norovirus Hu/GII.4/Hiroshima/B3/ZDDB/JPN

28474, 32884, 37234

2QI5 VPI BAI43322 2015 B425 10835, 15245, 13655. 240B5, narovirus Hu/Gll.4/Hirashima/I10/2007/JPN

28475, 32885, 372B5

2DIB VPI BAJ25074 20IB B42B I083B, I524B, I3B5B, 240BB, narovirus Hu/0C07ll8/2007/JP

2847G, 3288B, 3723B

2017 VPI BAP33334 2DI7 B427 10837, 15247, I3B57, 240B7, narovirus

28477, 32887, 37237 Hu/GII/JP/20l4/GII.PI7_GII.I7/Kawasaki323

2018 VPI ABQB3283 2018 B428 10838, 15248, 13B58, 240B8, norovirus

28478, 32888, 37238 Hu/GII Enepuru/NZ327/200G/NZ-

2019 VPI ABV55634 20IB B423 10833, 15243, 19B53, 240B8, norovirus

28479, 32883, 37233 Hu/GII.4/Shellharbour/NSW69GT/2006/A0S

2020 VPI ACV4I093 2020 B430 10840, 15250, 13BB0, 24070, narovirus Hu/GII.4/RiviBral635/2008/US

28480, 32890, 37300

2021 VPI ACV4I0BB 2021 B43I 10841, 15251, I3BBI, 24071, narovirus Hu/GI.4/l643/2008/US

28481, 32891, 37301

2022 VPI ACV88I30 2022 B432 10842, 15252, I3BB2, 24072, noravirus dag/C33/Viseu/2007/P T

28482, 32832. 37302

2023 VPI ACWI3927 2023 B433 10843, 15253, 13BB3, 24073, norovirus

28483, 32833. 37303 Hu/GII.4/RathminEs/NSW2B7R/2DD7/AUS

2024 VPI ACX3I885 2024 B434 10844, 15254, I9BB4, 24074, noravirus

28484, 32894, 37304 Hu/GII.4/Armidale/NSW390l/20D8/AU

2025 VPI ACX3I887 2025 B435 10845, 15255, I9BB5, 24075, noravirus

28485, 32895, 37305 Hu/GII.4/Westmead/NSW3639/2008/A0S

202G VPI ACX3I8BI 202B B43G I084B, I525B, I9BBB, 2407B, noravirus

28486. 3289B, 3730B Hu/GII.4/Sutherland/NSW505G/2007/AOS

2027 VPI ACZ37232 2027 B437 10847, 15257. 19667, 24077, noravirus Hu/GII.7/l738/2009/USA

28487, 32897, 37307

2028 VPI AD0I0375 2028 B438 10848, 15258, 19668, 24078, norovirus HU/GII.4/NEW

28488, 32898, 37308 0rleansl805/2009/0SA 2D2S PI AD085552 2029 B439 10849, 15259, I9BB9, 24079, norovirus HU/GII.4/PECS/HUN4322/20ID/HUN

28489, 32899, 37309

2030 VPI ADQ4377B 2030 B440 10850, 152B0, 19B70, 24080, norovirus

2849D, 32900, 37310 Hu/GII.4/B _E Bcroft/NSW305P/2003/AUS

2031 VPI ADQ4378I 2031 B44I 10851, 15261. 19671. 24081, norovirus

28491, 32901, 37311 Hu/GII.4/Teralba/NSW88IZ/2009/AUS

2D32 VPI A0D43783 2032 B442 10852, 15262, 19672. 24082, norovirus

28492, 32902, 37312 Hu/GII.4/Turramurra/NSW8B2U/2003/A S

2D33 VPI A0V37805 2033 B443 10853, 152B3. 19B73, 24083, norovirus Hu/GII.4/Seoul/D389/2009/K0R

28493, 32903, 37313

2D34 VPI ADV37807 2034 B444 10854, 15264, 19674, 24084. norovirus HU/GII.4/SEOUI/0B54/200B/K0R

28494, 32904, 37314

2035 VPI A0V37809 2035 B445 10855, 15265, 19675, 24085. norovirus Hu/GII.4/SEOul/092l/200a/K0R

28495, 32905, 37315

2036 VPI ADV378I3 203B B44B 10856, 15266, 19B7B, 2408B. norovirus Hu/GII.4/Seoul/0952/20IO/KOR

28496, 32906, 37316

2037 VPI A0V379I7 2037 B447 10857, I52B7, 19677. 24087, norovirus Hu/GII.4/Seoul/0902/200S/K0R

28497, 32907, 37317

2038 VPI ADV379IB 2038 B448 10858, 15268, 19B78, 24088, norovirus HU/GII.4/SBOUI/0945/2D09/K0R

28498, 32908, 37318

2030 VPI AEI834B9 2039 B449 10859, 15269, 19679, 2408B, norovirus Hu/GII.I2/ShBlby/2009/USA

28499, 32303, 37319

2040 PI AEP04093 204D B450 10860, 15270, 13680, 24030, norovirus pig/GII/Ch6/China/2009

28500, 32310, 37320

2041 VPI AED77282 2041 B45I 10861, 15271, 16681. 24031. norovirus Hu/GI.7/TCH-060/USA/2003

28501, 32911, 37321

2042 VPI AFA55I74 2042 B452 10862, 15272, I3B82, 24032, norovirus Hu/GII.I/Ascension208/20IO/USA

28502, 32312, 37322

2043 VPI AFC89B5B 2043 B453 I08B3, 15273, 13B83. 24033, norovirus Hu/GII.I3/VAI73/20IO/USA

28503, 32313, 37323

2044 VPI AFC89B59 2044 G454 I08B4, 15274, 13684, 24094, norovirus Hu/Gf.7/Pravidencel9I/2DID/USA

28504. 32314, 37324

2045 VPI AFC89BB2 2045 B455 10865, 15275, 13685, 24035, norovirus

28505, 32315. 37325 Hu/GII.3/GlastonburyllG4/2004/USA 2D4B VPI AFC89BB5 204B B45B I08BB, I527B, I9B8B, 2409B. nopovipus Hu/GII.2l/Salisburyl5D 20ll/USA

2850B.329IB, 3732B

2047 PI AFC89BB7 2047 B457 I08B7, I5277, I9687, 24097, narovirus

28507.329I7, 37327 Hu/GII.4/Minerva/CSI258/200G/OSA

2048 VPI AFDB2272 2048 B458 ID8B8. 15278, 19B88, 24098, murine narovirus 3

28508, 329I8, 37328

2048 VPI AFJ04707 2049 B459 I08B9, 15279, 19B89, 24099, narovirus Hu/Gll.4/I997/USA

28509, 32919, 37329

2050 VPI AFJ04708 205D B4B0 10870, 15280, I9B90, 24100, narovirus Hu/GII.4/Farmingtan

28510, 32920, 37330 Hills/2004/0SA

205I VPI AFJ0470e 205I B4BI 10871, 15281, 19691, 24101, noravirus Hu/BII.4/Minerva/2006/USA

28511, 32921, 37331

2052 VPI AFP8B593 2052 B4B2 10872, 15282, I9B92, 24102, narovirus Hu/GII.4/0hio/7l/20l2/0SA

28512, 32922, 37332

2053 VPI AFU55B8B 2053 B4B3 10873, 15283, I9B93, 24103, narovirus Hu/GII.4/Alb_rtaEII3l/2D04/CA

28513, 32923, 37333

2054 VPI AF055B8B 2054 B4B4 10874, 15284, I9B94. 24104, norovirus Hu/GII.4/AlbBrtaEII42/200B/CA

28514, 32924, 37334

2055 VPI AF055BB2 2055 B4B5 10875, 15285, 19695, 24105, norovirus Hu/GIL4/AlbertaElf90/2D0B/CA

28515, 32925, 37335

205B VPI AFU55B95 205G B4BB I087B, I528G, I9B9B, 24I0B, noravirus Hu/BII.4/AlbertaEI438/2006/CA

285IB, 32926.37336

2057 VPI AFU55B98 2057 B4B7 10877, 15287, 19697, 24107, norovirus Hu/GII.4/AlbertaEI498/2006/CA

28517, 32927.37337

2058 VPI AF05570I 2058 B4B8 10878. 15288, 19698, 24108, norovirus Hu/GII.4/AlbertaEI5l3/2006/CA

28518, 32928.37338

2D5B VPI AF055704 2059 B4B9 10879, 15289, I9B99. 24109. noravirus Hu/GII.4/Alb _B rtaEIB03/200B/CA

28519, 32929, 37339

20B0 VPI AF055707 20B0 B470 10880, 15290, 19700, 24110, norovirus Hu/GII.4/AlbertaEID09/Z008/CA

28520, 32930, 37340

20BI VPI AFU557I0 20BI B47I 10881, 15291, 19701. 24111, noravirus Hu/GII.4/AlbertaEII02/2008/CA

28521, 32931, 37341

20B2 VPI AFU557I3 20B2 B472 10882, 15292, 19702, 24112, noravirus Hu/GII.4/Alb _E rtaEI2IO/2008/CA

28522, 32932, 37342 2063 VPI AFU557IB 20B3 B473 10883, 15233, 13703, 24113, norovirus Hu/Gll.4/AfbBPtaEI425/2D0B/CA

28523, 32B33, 37343

20B4 VP! AF0557I9 20B4 B474 10884, 15234, 13704, 24114, norovirus Hu/GII.4/AlbertaEII09/2009/CA

28524, 32334, 37344

20B5 VPI AF055722 2DB5 B475 10885, 15235, 19705, 24115, norovirus Hu/GII.4/AlbertaEI045/2DI0/CA

28525, 32935, 37345

20BB PI AF055725 20BB B47B I088B, 15296, I970B, 24116, norovirus Hu/GII.4/AlbertaEIII9/2DI0/CA

28526, 32936, 3734B

20B7 VPI AF055728 20B7 B477 10887, 15297, 19707, 24117, norovirus Hu/GII.4/AlbertaEIZ04/20IO/CA

28527, 32937, 37347

20B8 VPI AF05573I 20B8 B478 10888, 15298, 19708, 24118, norovirus Hu/GII.4/AlbertaEI065/2DII/CA

28528, 32938, 37348

20BB VPI AF055734 20B9 B473 10889, 15299, 13703, 24119, norovirus Hu/GII.4/AlbertaEI388/20ll/CA

28529, 32939, 37349

2070 VPI AF055737 2070 B480 10890, 15300, 19710, 24120, norovirus Hu/GII.4/AlbertaEI003/20l2/CA

28530, 3294D, 37350

2071 VPI AF0B2B53 2071 B48I 10891, 15301, 13711, 24121, norovirus Hu/Gll.4/SG40I3-09/2004/SG

28531, 32341, 37351

2072 VPI AF092BB0 2072 B482 10892, 15302, 19712, 24122, norovirus Hu/GII.4/SG40IG-09/2004/SG

28532, 32942, 37352

2073 VPI AFU32BBI 2073 B483 10893, 15303, 19713, 24123, norovirus Hu/GII.4/SG4033-0l/2DD5/SG

28533, 32943, 37353

2074 VPI AFU32BB2 2074 B484 10894, 15304, 19714, 24124, norovirus Hu/GII,4/SG4033-02/2005/SG

28534, 32944, 37354

2075 VPI AFU32BB3 2075 B485 10895, 15305, 19715, 24125, norovirus Hu/GII.4/SG409l-06/200B/SG

28535, 32945, 37355

207B VPI AF092BB4 2D7B B48B I089B, I53D6, 19716, 24126, norovirus Hu/GII.4/SG4D39-08/2006/SG

28536, 32946, 37356

2077 VPI AF0B2BBB 2077 B487 10897, 15307, 19717, 24127, norovirus Hu/GII.4/SG4009-03/2006/SG

28537, 32947, 37357

2078 VPI AF092BB7 2078 B488 10898, I53D8, 19718, 24128, norovirus Hu/Gll.4/SG40I9-09/200G/SG

28538, 32948, 37358

207B VPI AFU32BB8 2073 B483 ID899, 15309, 19719, 24129, norovirus Hu/GII.4/SG4024-IO/200G/SG

28539, 32949, 37359 2D8D VPI AF092BB9 2080 B49D 10900, 15310, 19720, 24130, nnrovirus Hu/GII.4/SG4D35-ID/2DDG/SG

28540, 32950, 373B0

2081 VPI AFU92B70 2081 B49I 10901, 15311. 19721, 24131, norovirus Hu/GII.4/SG4060-IO/2006/SG

28541, 32951, 373BI

2D82 VPt AFU92B7I 2082 B492 10902, 15312, 19722, 24132, norovirus Hu/GII.4/SG406l-IO/2006/SG

28542, 32952, 373B2

2083 VPI AFU92B72 2083 B493 10903. 15313, 19723, 24133, norovirus Hu/Gll.4/SG4097-I0/2D06/SG

28543, 32953, 37363

2D84 VPI AF092B73 2084 B494 10904, 15314, 19724, 24134, norovirus Hu/Gll.4/SG40I5-I0/200B/SG

28544, 32954, 37364

2085 VPI AFUB2B74 2085 B495 10905, 15315, 19725, 24135, norovirus Hu/GII.4/SG4D30-l2/2006/SG

28545, 32B55, 37365

208B VPI AFU92B7B 208B B49B I090B, 15316. 19726, 24I3B, norovirus Hu/Gll.4/SG4058-I2/200G/SG

28546, 32956.37366

2087 VPI AFU92B77 2087 B497 10907, 15317, 19727, 24137, norovirus Hu/Gll.4/SG4077-I2/200B/SG

28547, 32957, 373B7

2D88 VPI AFU92B78 2088 B498 10908, 15318, 19728, 24138, norovirus Hu/GII.4/SG4007-OI/2007/SG

28548, 32958, 373B8

2089 VPI AF092B79 2089 B499 10909, 15319, 19729, 24139, norovirus Hu/GII.4/SG40IO-OI/2007/SG

28549.32959, 37369

2090 VPI AF092B80 2090 B500 ID9I0, 15320, I973D, 24140, norovirus Hu/GII.4/SG404l-0l/2OO7/SG

28550, 32960, 37370

2091 VPI AF092B8I 2091 B50I 10911, 15321, 19731, 24141, norovirus Hu/GII.4/SG4047-OI/2007/SG

28551, 32961, 37371

2092 VPI AF092B82 2092 B502 10912, 15322, 19732, 24142, norovirus Hu/GII.4/SG405l-0l/2007/SG

28552.32962.37372

2093 VPI AFU92B84 2D93 B503 10913. 15323, 19733, 24143, norovirus Hu/GII.4/SG4042-07/2007/SG

28553, 329B3, 37373

2094 VPI AFU92B85 2094 B504 10914, 15324, 19734, 24144, norovirus Hu/GII.4/SG4045-07/Z007/SG

28554, 32964, 37374

2095 VPI AFU92G86 2095 G505 10915, 15325, 19735, 24145. norovirus Hu/GII.4/SG4052-08/2007/SG

28555. 32965.37375

2096 VPI AF092B87 209B B50B 10916, 15326, 19736. 24146, norovirus Hu/GII.4/SG4065-08/2007/SG

28556, 32966, 37376 2D37 VPI AF092G88 2037 G507 10917. 15327. 19737, 24147, norovirus Hu/GH.4/SB4D75-DB/ZDD7/SG

28557, 32967.37377

2098 VPI AFU32G83 2098 G508 10918, 15328, 19738, 24148, norovirus Hu/GII.4/SG4086-09/2007/SG

28558, 32968, 37378

2033 PI AF0326S0 2033 6503 10919, 15329, 19739, 24149, norovirus Hu/GII.4/SG4087-09/2007/SG

28559, 329G9, 37379

2100 VPI AF032B3I 2I0D G5I0 10920, 15330, 19740, 24150, norovirus Hu/GII.4/SG40ll-09/2D07/SG

28560, 32970, 37380

2101 VPI AFU32G32 2101 6511 10921, 15331, 19741, 24151. norovirus Hu/GII.4/SG40G3-IO/2007/SG

28561, 32971.37381

2102 VPI AF092693 2102 G5I2 10922, 15332, 19742, 24152, norovirus Hu/GII.4/SG4069-OI/2008/SG

28562, 32972, 37382

2103 VPI AFU92G94 2103 G5I3 ID923, 15333, 13743, 24153, norovirus Hu/GII.4/SG4079-07/2008/SG

28563, 32973, 37383

2104 VPI AFUB2Be5 2104 G5I4 10924, 15334, 19744, 24154, norovirus Hu/GII.4/SG4073-tl/2008/SG

28564, 32974, 37384

2105 VPI AF032G3B 2105 G5I5 10325, 15335, 19745, 24155, norovirus Hu/GII.4/SG4D92-ll/2008/SG

28565, 32975, 37385

2I0G VPI AFU32G37 2IDG G5IG 10926, 15336, 19746, 24156, norovirus Hu/Gll.4/SG40I5-I2/2D08/SG

28566, 32976, 37386

2107 VPI AF032B38 2107 6517 10927, 15337, 19747, 24157. norovirus Hu/GII.4/SG40l8-l2/2008/SG

28567.32377, 37387

2108 VPI AF032G33 2108 6518 10928. 15338, 19748, 24158, norovirus Hu/GII.4/SG406l-OI/2009/SG

28568, 32978. 37388

2103 VPI AF032700 2103 G5I9 10929, 15339, 19749, 24159, norovirus Hu/GII.4/SG4067-DI/2009/SG

28569, 32979, 37389

2110 VPI AF09270I 2110 6520 10930, 15340, 19750, 24160, norovirus Hu/GII.4/SG4004-D3/2009/SG

28570.32980, 37330

2111 VPI AFU32702 2111 6521 10331. 15341, 13751, 24IGI, norovirus Hu/GII.4/SG4023-05/2009/SG

28571, 32981, 37331

2112 VPI AF092703 2112 6522 10932, 15342, 19752, 24162, norovirus Hu/GII.4/SG4028-07/2009/SG

28572, 32982, 37392

2113 VPI AF092704 2113 6523 10933, 15343, 19753, 24163. norovirus Hu/GII.4/SG4070-Q7/2009/SG

28573, 32983, 37393 2114 VPI AFU92705 2114 B524 10934, 15344, 19754, 24164, noravirus Hu/GII.4/SG4040-08/2009/SG

28574, 32984.37394

2115 VPI AFU9270B 2115 B525 10935, 15345, 19755. 24165. noravirus Hu/GII.4/SG404l-09/2009/SG

28575, 32985, 37395

2IIG VPI AFU92707 2116 B52B 10936, 15346, 19756, 24166, noravirus Hu/GII.4/SG4044-09/2009/SG

28576.32986, 37396

2117 PI AFU927D8 2117 B527 10937, 15347, 19757, 24167, noravirus Hu/GII.4/SG4D4B-D3/2DD9/SG

28577, 32987. 37397

2118 VPI AFU92709 2118 B528 10938, 15348. 19758, 24168, noravirus Hu/GII.4/SG4047-D9/2009/SG

28578, 32988, 37398

2119 VPI AFU927ID 2119 B529 I0B39, 15349, 19759, 24169, noravirus Hu/GII.4/SG405l-09/2D09/SG

28579.32989, 37399

2I2D VPI AFU927II 2I2B B53D 10940, 15350, 19760, 24170, noravirus Hu/GII.4/SG4D57-Q9/2009/SG

28580.32990, 37400

2121 VPI AF0927I2 2121 B53I 10941, 15351. 19761. 24171, noravirus Hu/GII,4/SG4058-ID/2009/SG

28581, 32991, 37401

2122 VPI AF0927I3 2122 B532 10942, 15352, 19762, 24172, noravirus Hu/GII.4/SG40BI-IO/2009/SG

28582, 32992, 37402

2123 VPI AFU927I4 2123 B533 10943, 15353, 19763, 24173, noravirus Hu/GII.4/SG40B2-IO/2009/SG

28583, 32993, 37403

2124 VPI AFU927I5 2124 6534 10944, 15354. 19764. 24174, noravirus Hu/GII.4/SG4075-l2/2009/SG

28584, 32994, 37404

2125 VPI AFU927I7 2125 B535 10945, 15355, I97B5, 24175, noravirus Hu/GII.4/SG40l4-04/2DI0/SG

28585, 32995, 37405

2I2B VPI AFU927I8 2I2B 6536 I094B, 15356, 19766, 24176, noravirus Hu/GII.4/SG4D51-08/2OIQ/SG

28586, 32996, 37406

2127 VPI AFU927I9 2127 6537 10947, 15357, 19767, 24177, noravirus Hu/GII.4/SG4053-08/20IO/SG

28587, 32997, 37407

2128 VPI AFU9272D 2128 B538 10948, 15358, 19768, 24178, noravirus Hu/GII.4/SG4054-08/20ID/SG

28588, 32998, 37408

2129 VPI AFU9272I 2129 6539 10949, 15359, 19769, 24179, noravirus Hu/Gll.4/SG4002-I2/2DI0/SG

28589, 3299B, 37409

2I3D VPI AFU92722 2I3D 6540 10950, 15360, 19770, 24180, noravirus Hu/GII.4/SG4009-OI/20ll/SG

28590, 33000.37410 2131 VPI AFU92723 2131 G54I 10951. 15361, 19771, 24181, norovirus Hu/GII.4/SG40IO-OI/20ll/SG

28591, 33001, 37411

2132 VPI AG079474 2132 G542 10952, 15362, 19772, 24182. norovirus Hu/GII.3/0l-l3/477/200l/A0

28592, 33002, 37412

2133 VPI AGD79475 2133 6543 10953. I53G3, 19773, 24183, norovirus Hu/GII.3/02-l3/424cons/2002/AU

28593, 33003, 37413

2134 VPI AGD7947G 2134 6544 10954. 15364, 19774, 24184, norovirus Hu/GII.3/4l/89/2006/AU

28594, 33004, 37414

2135 VPI AGD79477 2135 G545 10955, 15365, IB775, 24185, norovirus Hu/GII.3/84/46/2007/AU

28595, 33005, 37415

2136 VPI AGD79478 2I3G 6546 10956, 15366, 19776, 24186, norovirus Hu/GII,3/693/425/20D8/A0

2859B, 33006, 374IB

2137 VPI AGD79479 2137 6547 ID957, 15367, 19777, 24187, norovirus Hu/GII.3/537/547/20IO/AU

28597, 33007, 37417

2138 VPI AGH2475D 2138 6548 10958, 15368, 19778, 24188, norovirus Hu/GII.4/IT00/ITA

28598, 33008, 37418

2139 VPI AGI37922 2139 6549 10959, 15369, 19779, 24189, norovirus HU/GII.4/SBOUI/I07I/20I0/ 0R

28599, 33009. 37419

2I4D VPI AGM4G344 2140 6550 10960, 15370, 19780. 24100, norovirus HU/GII/SEOUII055/K0R/20I0

28600, 33010, 37420

2141 VPI AGM4B347 2141 6551 10961, 15371, 19781, 24191, norovirus HU/GII/SBOUII072/K0R/2010

28B01. 33DII, 37421

2142 VPI AGM4G349 2142 6552 10962, 15372, 19782, 24192, noroviros Hu/GII/Seoull282/KOR/20IO

28G02, 33012, 37422

2143 VPI AGM4G355 2143 6553 I09B3, 15373, 19783, 24193, norovirus HU/GII/SBOUII488/K0R/20II

28603, 33DI3, 37423

2144 VPI AG 4G359 2144 6554 10964, 15374, 19784, 24194, norovirus Hu/GII/Seoull033/KOR/20IO

28604, 33014, 37424

2145 VPI AGM463G2 2145 6555 10965, 15375, 19785, 24195, norovirus HU/GII/SBOUII08B/K0R/20I0

28605, 33015, 37425

2I4B VPI AGM4G3GG 2I4G 6556 10966, 15376, 19786, 24196, norovirus HU/GII/SBOUII39I/K0R/2DI0

28B06, 33016, 37426

2147 VPI AGM4G3G7 2147 6557 I09B7, 15377, 19787. 24197. norovirus HU/GII/SBOUII4I2/K0R/2DI0

28607. 33017. 37427 2148 PI AGM4637Q 2148 G558 ID9BB, 15378, 19788, 24198, norovirus Hu/GII/SBDulf37B/K0 /20iD

28B08, 33DI8, 37428

2149 VPI AGM4B375 2149 6559 10969. 15379, 19789, 24199, norovirus HU/GII/SBOUII388/K0R/20I0

28609, 33019, 37429

2150 VPI AG 4B377 2150 B5BD 10970, 15380, 19790, 24200, norovirus HU/GI[/SBOUI!40Q/K0 /2DIQ

28610, 33020, 37430

2151 VPI AGM4G379 2151 B5BI 10971, 15381, 19791, 242DI, norovirus HU/GII/SEOUII449/K0R/20II

28611, 33021, 37431

2152 VPI AGM4G384 2152 B5G2 10972, 15382, 19792. 24202, norovirus Hu/GII/Seoull456/K0R/20ll

28612, 33022, 37432

2153 VPI AGM4G38B 2153 B5G3 10973, 15383, 19793, 24203, norovirus HU/GII/SBOUII034/K0R/20I0

28613, 33023, 37433

2154 VPI AG 46388 2154 B5B4 10974, 15384, 19794, 24204, norovirus HU/GII/SBQUII049/KDR/ZDID

28614, 33024.37434

2155 VPI AG 4B382 2155 B5B5 10975, 15385, 19795, 24205, norovirus HU/GII/SBOUIII2I/K0R/2DI0

28BI5, 33025, 37435

2I5B VPI AGM4G395 2I5B B5BB I097B, 15386, I979G, 24206, norovirus HU/GII/SBDUII29B/K0R/20I0

28616, 33026, 37436

2157 VPI AGM4G398 2157 B5B7 10977, 15387, 19797, 24207, norovirus HU/GII/SBDUII409/K0R/20I0

28617, 33027, 37437

2158 VPI AGM4B4DI 2158 B5B8 10978, 15388, 19798. 24208, norovirus HU/GII/SBOUII444/K0R/20I0

28BI8.33028, 37438

2158 VPI AG 4B4D3 2159 B5B9 10979, 15389. 19799, 24209, norovirus HU/GII/SBOUII445/K0R/20I0

28619, 33029, 37439

2IBD VPI AGM4G407 2IBD B57D ID98D, 15390, I98D0, 24210, norovirus HU/GII/SBOUII835/K0R/20II

28620, 33030, 37440

2IBI VPI AGM4B4DB 2IBI G57I 10981, 15391, 19801, 24211, norovirus HU/GII/SBOUII032/K0R/20I0

28621, 33031, 37441

2IB2 VPI AG 4B4I3 2IB2 B572 10982, 15392, 19802, 24212. norovirus HU/GII/SBOUII073/K0R/20I0

28B22.33032, 37442

2IB3 VPI AG 4G4I5 2IB3 B573 10983, 15393, 19803, 24213, norovirus HU/GII/SBDUII2II/K0R/20I0

28623.33033, 37443

2IG4 VPI AGM4B4I9 2IB4 G574 10984, 15394, I98D4. 24214. norovirus Hu/GII/Seoull259/KOR/20IO

28624.33034, 37444 2IG5 VPI AGM4G42I 2165 0575 10985. 15395, 1980S, 24215, norovirus Hu/GII/Seaull321/KD /2DID

28625, 33035, 37445

2IGG VPI AGM46425 2IGG G57G 10986, 15396, 19806, 24216, nornvirus Hu/GII/Seoull35l/KOR/20IO

28G26, 33036, 37446

2IG7 VP! AGM4G427 2IG7 6577 10987, 15397, 19807, 24217, nornvirus HU/GII/SBDUII43I/K0R/20I0

28627, 33037, 37447

2IG8 VPI AG 4G43I 2IG8 6578 10988, 15398, 19808, 24218, nornvirus HU/G[I/SEOUII45D/K0 /2DI1

28628, 33038, 37448

2IG9 PI AGNII43D 2IG9 6579 10989, 15399, 19809, 24219, narovirus Hu/GIV.I/CCDC GRIII3-59/CHN/20II

28629, 33039, 37449

2I7G VPI AGGG4038 2I7D 6580 10990, 15400, 19810, 24220, norovirus Hu/GII.3/TCH-l04/USA/2002

28G30, 33040, 37450

2171 VPI AGQ64D4Q 2171 6581 10991, 15401, 19811, 24221, norovirus Hu/Gll.7/TCH-I34/USA/20G3

28631, 33041, 37451

2172 VPI AGQG4D42 2172 6582 10992, 15402, 19812, 24222. norovirus Hu/GII.I2/Texas/EI3842/USA/20GQ

28B32, 33042, 37452

2173 VPI AGS4I450 2173 6583 10993, 15403, 19813, 24223, norovirus Hu/GII.42006b/092895/2008/USA

28B33, 33043. 37453

2174 VPI AGTG252I 2174 6584 10994, 15404, 19814, 24224, norovirus Hu/GI.6/TCH-099/USA/2003

28B34, 33044, 37454

2175 VPI AGTG2523 2175 6585 10995. 15405, 19815, 24225, norovirus Hu/GII.2/TCH-5B0/USA/2D02

28635. 33045, 37455

2I7G VPI AGV4D22I 2I7G 658G 10996. 15406, 19816, 2422G, narovirus Hu/GII.4/JPI0909/20l2/JPN

28B3B, 3304B, 37456

2177 VPI AGV76553 2177 6587 10997, 15407. 19817. 24227, norovirus Hu/GII.4/35444252/AUS/20l2

28B37. 33047, 37457

2178 VPI AGV7G554 2178 6588 10998, 15408, 19818, 24228, norovirus Hu/GII,4/30934022/AUS/20l2

28B38, 33048, 37458

2179 VPI AGV7B555 2179 6589 10999, 15409, 19819. 24229, norovirus Hu/GII.4/937B22BI/AUS/2DI2

28B39, 33049. 37459

2180 VPI AGV7G55G 2180 6590 IIDOO, 15410. 19820, 24230, norovirus Hu/GII.4/2l859972/AUS/ZOI3

28B40, 33050, 37460

2181 VPI AGV7G557 2181 6591 IIOOI, 15411, 19821, 24231, narovirus Hu/GII.4/2l8599G4/AUS/20l2

28641, 33051, 37461 2182 VPI AGV7B558 2182 B592 11002. 15412. 19822. 24232, norovirus Hu/GII.4/2l859969/AUS/20l3

28642, 33052, 374B2

2183 VPI AGV7B559 2183 6593 11003, 15413, 19823, 24233, norovirus Hu/GII.4/2l859973/AUS/20l3

28B43, 33053, 374B3

2184 VPI AGV7B5BD 2184 B594 11004, 15414, 19824, 24234, norovirus Hu/GII.4/2l859977/AUS/20l3

28B44, 33054, 374B4

2185 VPI AGV765BI 2185 B595 11005, 15415, 19825, 24235. norovirus Hu/GII.4/2l859978/AUS/20l3

28B45.33055, 374B5

2I8B VPI AGV7B5G2 2I8B B59B IIOOB. 15416, I982B, 24236, norovirus Hu/GII.4/2l859980/AUS/20l3

28B46, 3305B, 37466

2187 VPI AGV7B5B3 2187 B597 11007, 15417, 19827, 24237, norovirus Hu/GII.4/3376503l/AUS/20l2

28647, 33057, 37467

2188 VPI AGV7B5B4 2188 B598 11008, 15418, 19828, 24238, norovirus Hu/GII.4/32973745/AUS/20l2

28648, 33058.37468

2189 VPI AGV7B5B5 2189 6599 11009, 15419, IB829, 24239, norovirus Hu/GII.4/3476073l/AUS/20l2

28649, 33059, 37469

2I9D VPI AGV7B5BB 2I9D BBOD IIOIO, 15420, 19830, 24240, norovirus Hu/GII.4/30949403/AUS/20l2

28650, 33060, 37470

2191 VPI AGV7B5B7 2191 BBDI IIOII, 15421, 19831, 24241, norovirus Hu/GII.4/35857786/AUS/2DI2

28651, 33061, 37471

2192 VPI AGV7B5B8 2192 BBD2 11012. 15422, 19832, 24242, norovirus Hu/GII.4/36l26758/AUS/20l3

28B52, 33062, 37472

2193 VPI AGV7G5B9 2193 BBD3 11013, 15423, 19833, 24243, norovirus Hu/GII.4/36285l94/AUS/20l2

28B53, 33063, 37473

2194 VPI AGV7B57Q 2194 BBD4 11014, 15424, 19834, 24244, norovirus Hu/GII.4/90l8G7IO/AUS/20l2

28B54, 33064, 37474

2195 VPI AGV7B57I 2105 BBD5 11015, 15425, 19835. 24245, norovirus Hu/GII.4/3099B947/AUS/20l2

28655, 33065, 37475

2I9B VPI ABV7B572 2I9B BBD6 11016, 15426, 1983Β. 2424B, norovirus Hu/GII,4/35408489/AUS/20l2

28656, 33066, 37476

2197 VP! AGV7G573 2197 BBD7 11017, 15427, 19837, 24247, norovirus Hu/GII.4/ll992339/AUS/20!2

28657, 33067, 37477

2198 VPI AGV7B574 2198 BBG8 11018, 15428, 19838, 24248. norovirus Hu/GII.4/3450GI58/AUS/20l2

28658, 330B8, 37478 2I93 VPI AGV7B575 2I93 BBB9 IIOIB, I5423, I3839, 24249, nDrovirus Hu/GII.4/34790954/AUS/20l3

28B59. 33BBB, 3747B

22DD VPt AHA44844 22B0 BBIB II020, I5430, I3840, 2425B, norovirus Hu/GII.4/AlbertaEI063/2OI2/CA

28BB0, 33070, 37480

220I VPI AHA44847 220I BBII II02I, I543I, I384I, 2425I, narovirus Hu/Bfl.4/AlbertaEI3S7/20!1/CA

28BBI, 33071, 3748I

2202 VPI AHBB2404 22D2 BBI2 II022, I5432, I9842, 24252, norovirus Hu/GII.4/Jiangsul/ZDII/CHN

28BG2, 33072, 37482

2203 VPI AHBB240B 2203 BBI3 II023, I5433, I9843, 24253, norovirus Hu/Gf[.4/Jiangsu2/2D12/CHN

28BB3, 33073, 37483

22D4 VPI AID5I5I5 2204 BBI4 II024, I5434, I3844, 24254. noravirus I2-AS-I/2DI2/GII.4

28BB4, 33D74, 37484

2205 VPI AID5I5I7 2205 BBI5 11025. 15435, 19845, 24255, norovirus I3-AV-I-6/20I2/GII.4

28BB5, 33075, 37485

220B VPI AID5I5I9 220B GBIG 11026, 15436, 19846, 24256, norovirus I3-AV-I-I0/20I2/GII.4

28666, 33076, 37486

2207 VPI AID5I522 2207 GBI7 11027, 15437, 19847, 24257, norovirus I3-BE-4/20I2/GII.4

286B7, 33077, 37487

2208 VPI AI05I53I 2208 G618 11028, 15438. 19848, 24258, norovirus I2-CG-2-4/20I2/GII.4

28668, 33078. 37488

2209 VPI AID5I534 220B 66IS 11029, 15439, 19849, 24259, norovirus I3-Z-2/2DI2/GII.4

28660, 33079, 37489

22I0 VPI AIL49840 22I0 BB20 11030, 15440. I985D, 242B0, norovirus

28670, 33080. 37490 JB03l230054/Luohu/0B/l2/20l2/SZ/CHN

22II VPI AIL49843 22II BG2I 11031, 15441, 19851, 24261, norovirus

28671, 33081, 37491 JB03l230049/Nanshan/0B/l2/20l2/SZ/CHN

22I2 VPI AIV999I4 22I2 BG22 11032, 15442, 19852, 24262, norovirus Hu/GII.4/gg-l2-08-04/20l2/K

28672, 33082. 37492

22I3 VPI AJPI3BI9 22I3 G623 11033, 15443. 19853, 24263, norovirus GI.2

28G73, 33083, 37493

22I4 VPI AJPI3B20 22I4 6B24 11034, 15444, 19854, 242G4, norovirus GI.3

28G74, 33084. 37494

22I5 VPI AJPI3B2I 22I5 BG25 11035, 15445, 19855, 24265, norovirus GII.3

28B75, 33085, 37495 22IG VPI AJPI3B22 22IB BB2B II03B, I544B, I985B, 242BB, norovirus GII.6

28876, 3308B, 3749B

22I7 VPI AJPI3B23 22I7 BB27 11037, 15447, 19857, 242B7, norovirus GII.I2

28B77, 33087, 37497

22I8 VPI AJWB7354 22I8 BB28 11038, 15448, 19858, 242B8, norovirus Hu/GI.Pb/GI.G/Kaohsiung/14-A- 28B78, 33088, 37498 7/2014/TW

22IB VPI AJWB7357 22IB BB29 11039, 15449, 19850. 242B9, norovirus Hu/GII.P7/GII.G/HualiEn/l4-AR- 28B79, 33080, 37499 I/20I4/TW

2220 VPI AJW67359 2220 BB30 11040, 15450, I98B0, 24270, norovirus Hu/GII.P7/GII.6/New/Taipei/l4-AG- 28B80, 33090, 37500 3/2014/TW

222I VPI AJWB73B2 222I BB3I 11041, 15451, 19861. 24271, norovirus Hu/GII.P7/GII.6/Kaohsiung/l4-Z- 28G81, 33091, 37501 2/2014/TW

2222 VPI AJW67368 2222 BB32 11042, 15452, I98B2, 24272, norovirus Hu/GII.P22/GII.5/Kaohsiung/l2-AV- 28682, 33092, 37502 I/20I2/TW

2223 VPI AJWB737I 2223 BB33 11043, 15453, I98B3, 24273, norovirus Hu/GII.P22/GII.5/Taoyuan/l2-BB- 28B83, 33093, 37503 4/2012/TW

2224 VPI AJWB7374 2224 BB34 11044, 15454, I98B4, 24274, norovirus Hu/GII.PI6/GII.I3/NBw/Taipei/l3- 28B84, 33094, 37504 BA-I/2013/TW

2225 VPI AJWB7377 2225 BB35 11045, 15455, I98B5, 24275, norovirus I4-H-2/20I4/GI.P4/GI.4

28B85, 33095, 37505

222B VPI AJXI8IB0 222G BB3B 11046, I545B, I98B6, 24276, norovirus 07-AF-I/2007/GII.P22/GII.5

28686, 33096, 37506

2227 VPI AJXI8I93 2227 BB37 11047, 15457, I98B7, 24277, norovirus II-FM-I/20II/GII.P22/GII.5

28687.33097, 37507

2228 VPI AJZ77004 2228 BB38 11048, 15458, 19868, 24278, norovirus 06-AM- 28688, 33008, 37508 ll/2006/GII.4/YersekB/20BGa

2229 VPI AJZ770I0 2229 BB39 11049, 15459, 19869, 24279, norovirus 08-F- 28B89, 33099.37509 2/2008/GII.4/D _B nHaag/2006b

2230 VPI AJZ770I3 2230 BB40 11050, I54B0, 19870, 24280, norovirus 08-W- 28B90, 33100, 37510 l/2008/GII.4/A _P Bldoorn/2007

223I PI AJZ770I5 223I BB4I 11051, 15461, 19871, 24281, norovirus 09-FJI- 28B91, 33101, 37511 2/20D9/GII.4/NBw0rlBans/200B

2232 VPI AJZ770I9 2232 BB42 11052, 15462, 19872, 24282, norovirus 09-N- 28692, 33102, 37512 l/2009/GII.4/DenHaag/2006b 2233 VPI AJZ77D22 2233 GG43 11053. I54B3, 19873, 24283, norovirus l3-Z-2/2DI3/GII.Pe/GII.4/Sydn _B y

28B03, 33103, 37513

2234 VPI AJZ77027 2234 GG44 11054, I54B4, 19874, 24284, norovirus l2-BA-l/20l2/GII.Pe/GII.4/Sydn _B y

28694, 33104, 37514

2235 VPI AJZ77030 2235 GG45 11055, 15465, 19875, 24285, norovirus I2-CG-2- 28695, 33105, 37515 4/20l2/GII.P _E /GII.4/Sydney

223G VPI AJZ77033 223G G64G 11056, 15466, 10876, 24286, norovirus I2-AY- 28696, 33I0G, 37516 l/20l2/GII.4/New0rleans/200g

2237 VPI AJZ7703G 2237 GG47 11057, I54B7, 19877, 24287, norovirus I2-AY- 28697, 33107.37517 2/2OI2/6ll.4/NewOrlEans/2009

2238 VPI A E3I849 2238 GG48 11058, I54B8, 19878, 24288, norovirus Hu/GII.4/PRG87G/20IO/ITA

28698, 33108, 37518

2233 VPI AKE3I852 2239 GG49 11059, 15469, 19879, 24289. norovirus Hu/GII.4/PRII47l/20ll/ITA

28690, 33109.37519

224D VPI AKE3I855 224D GG5D HOBO, 15470. 19880. 24290. norovirus Hu/GII.4/PR784l/20ll/ITA

28700.33110, 3752D

224! VPI AKE3I858 2241 G65I IIOBI, 15471, 19881, 24291, norovirus Hu/GII.4/PR9474/20ll/ITA

28701, 33111, 37521

2242 VPI AKE3I86I 2242 GG52 11062. 15472. 19882. 24292, norovirus Hu/Gll.4/PR328/20I3/ITA

28702, 33112. 37522

2243 PI A E3I8G4 2243 GG53 11063, 15473, 19883. 24293. norovirus Hu/GII.4/PA28B/2DII/ITA

28703, 33113, 37523

2244 VPI AKE3I867 2244 GG54 11064, 15474, 19884, 24294, norovirus Hu/GII.4/PA278/20ll/ITA

28704, 33114, 37524

2245 VPI A E3I87Q 2245 G655 11065. 15475, 19885. 24295, norovirus Hu/GII.4/PA330/20ll/ITA

28705, 33115, 37525

224G PI A E3I873 2246 GG5G 11066, 15476, 19886, 24296, norovirus Hu/Gll.4/PA59/20I2/ITA

28706, 33116, 37526

2247 VPI A E3I876 2247 6G57 11067, 15477, 19887, 24297, norovirus Hu/Gll.4/PA99/20I2/ITA

28707, 33117.37527

2248 PI AKF02368 2248 BG58 11068. 15478, 19888, 24298. norovirus Gil

28708, 33118, 37528

2249 VPI A F42429 2249 BG59 11069, 15479, 19889, 24299, narovirus Gil

28709, 33119, 37529 Z25D VPI AKF42434 2250 B66D II070, I5480, I3830, 24300. norovirus Gil

287I0. 33I20, 37530

225I PI AKF42437 225I 66GI 1I07I, I548I, I3B9I. 2430I, norovirus Gil

287II, 33I21, 3753I

2252 VPI ALA27427 2252 66G2 II072, I5482, I3892, 24302. norovirus Hu/GII.P4_GII.4/Min _B rva/2006/USA

287I2, 33I22.37532

2253 VPI ALD0B6I8 2253 6BB3 II073. I5483, I9833. 24303, norovirus Hu/GII.PI7_GII.I7/PR6G8/20I5/ITA

287I3. 33I23, 37533

2254 VPI ALMB6644 2254 6664 II074. I5484, I9894. 24304, noravirus Hu/Gll.4/SPHC2048/20I2/CHN

287I4, 33I24, 37534

2255 VPI ALM96B45 2255 6665 1I075, I5485, I3835, 24305, norovirus Hu/Gll.4/SPHC27I5/2DI2/CHN

287I5, 33I25, 37535

2256 VPI ALM36646 225B 6666 II07B, I5486. I3896, 2430B, noravirus Hu/Gll.4/SPHCII34/20I2/CHN

287I6.33I2B, 3753B

2257 VPI ALM96647 2257 6667 II077, I5487, I98B7, 24307, norovirus Hu/Gll.4/SPHCII83/20I2/CHN

28717, 33127, 37537

2258 VPI ALM9883I 2258 6668 11078, 15488, 19898, 24308, norovirus Gil

28718, 33128, 37538

2259 VPI ALMB88B2 2259 6663 11079, 15483, 13893, 24303, noravirus Gil

28719, 33129, 37533

2260 VPI ALM988B3 22BD 6670 11080, 15430, I39DD, 24310. norovirus Gil

2872D, 33130, 37540

226I VPI ALM38894 226I BB7I 11081, 15491, 13301. 24311, norovirus Gil

28721, 33131, 37541

2262 VPI ALM98895 2262 6672 11082, 15492, 13902, 24312, norovirus Gil

28722, 33132, 37542

2263 VPI ALM9889B 2263 6G73 11083, 15433, 13303, 24313, norovirus Gil

28723, 33133, 37543

2264 VPI ALM98897 2264 6674 11084, 15434, I9B04, 24314, norovirus Gil

28724, 33134, 37544

2265 VPI ALM98899 2265 6B75 11085, 15495, 13305, 24315, noravirus Gil

28725.33135, 37545

2266 VPI ALM9890I 22BB 6B7B 11086, I543B, I390B, 243IB, norovirus Gil

28726, 33I3B.37546 2267 VPI ALM98e07 22B7 BB77 II087, I5497. I9907, 243I7, noravirus Gil

28727, 33I37.37547

22G8 VPI AL 989I0 22B8 BG78 II088, I5498, 19308. 24318, norovirus Gil

28728.33138, 37548

22B9 VPI ALM989I3 22B9 BG79 11089, 15499, 19909, 24310, noravirus Gil

28729, 33139, 37549

227D VPI ALM089IB 2270 BG80 11090, 15500, 19910, 24320, noravirus Gil

28730, 33140, 37550

227I VPI ALT54478 227I BB8I 11091, 15501, 19911. 24321, noravirus Hu/GII.4/AlbertaEI350/20l4/CA

28731, 33141, 37551

2272 VPI ALT54488 2272 BB82 11092, I55D2, 19912, 24322, norovirus Hu/GI.7/AlbertaEI404/20l2/CA

28732, 33142, 37552

2273 VPI ALT5449I 2273 GB83 11093, 15503, 19913, 24323, norovirus Hu/GII.4/AlbertaSPI/2DIZ/CA

28733, 33143, 37553

2274 VPI ALT54494 2274 BB84 11094, 15504, 19914, 24324, norovirus Hu/GII.4/AlbertaSPI/20l3/CA

28734, 33144, 37554

2275 VPI BAMB5003 2275 BB85 11005, 15505, 19915, 24325, norovirus Hu/GI.7/2009/Miyagi/JP

28735, 33145, 37555

227B VPI BAMB5005 227B GB8B 11096, I550B, 19916, 24326, norovirus Hu/0ll.3/2009/Miyagi/JP

28736, 33146, 37556

2277 VPI BAMB5007 2277 GB87 11097, 15507, 19917. 24327. noravirus Hu/GII.B/2009/Miyagi/JP

28737, 33147, 37557

2278 VPI CCX28B04 2278 GG88 11098, I55D8, 19918, 24328, norovirus Hu/Gli.4/C000DG63I/20!I/UK

28738, 33148.37558

227B VPI CCX28B07 2279 GB89 11099, 15509, 19919, 24329, norovirus Hu/GII.4/C00007876/20ll/0

28739, 33149, 37559

2280 VPI CCX28BI9 2280 BG90 MOO. 15510, 19920, 24330, norovirus Hu/GII.4/C00D07892/20ll/0

28740, 33150, 37560

228I VPI CCX28B22 228I BB9I 11101, 15511, 19921,24331,28741, norovirus Hu/GII.4/CD0007893/20ll/0

33151, 375BI

2282 VPI CCX28B25 2282 6692 IIID2, 15512, 19922, 24332, norovirus Hu/GII.4/C00007B04/20ll/UK

28742, 33152, 375B2

2283 VPI CCX28B28 2283 G693 11103, 15513, 19923, 24333, norovirus Hu/GII.4/C00007905/20ll/U

28743, 33153, 375G3 2284 VPI CCX28B3I 2284 6B94 III04, I55I4. I9924. 24334, noravirus Hu/G11.4/C00DD73I5/2DI0/U

28744, 33I54, 375B4

2285 VPI CCX28B34 2285 BB95 III05, I55I5, I9925, 24335, norovirus. Hu/GII.4/C000079l6/20ll/UK

28745, 33I55, 375G5

228B VPI CCX28B37 228B BB9B IIIOB, I55IB, I9B2B, 2433B, narovirus Hu/GII.4/C000079l8/20ll/UK

2874B, 33I5B, 375BB

2287 VPI CCX28B4D 2287 BG97 III07, I55I7. 19927. 24337, norovirus Hu/Gll.4/C00007927/20I0/UK

28747, 33157, 375B7

2288 VPI CCX28B43 2288 BB98 11108, 15518, 19928, 24338, noravirus Hu/BII.4/CDDDD7328/20l!/U

28748, 33158, 375B8

2289 VPI CCX28B4B 2289 B699 IIIOB. 15519, 19929, 24339, norovirus Hu/Gll.4/C00007934/20I0/UK

28749, 33159.375B9

2290 VPI CCX28B49 229D B700 IIIIO, 15520, 19930, 24340, norovirus Hu/GII.4/C0000794l/20ll/UK

28750.33IB0, 37570

229! PI CCX28B52 229I B70I 11111, 15521.19931, 24341.28751, norovirus Hu/GII.4/C00007952/20ll/UK

33IBI, 37571

2292 VPI AEEIDOOO 2292 B702 IIII2, 15522, IB932, 24342, murine norovirus GV/NIH-2409/2005/USA

28752, 33IB2, 37572

2293 VPI AEEID0I2 2293 B703 IIII3, 15523, 19933, 24343, murine norovirus GV/NIH-2750/2005/USA

28753, 33IB3, 37573

2294 VPI AGJ52I72 2294 B704 IIII4, 15524, 19934, 24344, norovirus Hu/Gll.4/Huzhnul2l/20I2/CHN

28754, 33IB4, 37574

2295 VPI AGJ52I73 2295 B705 IIII5, 15525, 19935, 24345, norovirus Hu/GII.4/Huzhoul22/2DI2/CHN

28755, 33IB5, 37575

2296 VPI AGJ52I74 229B B70B IIIIB, I552B, 19936, 2434B, norovirus Hu/Gll.4/Huzhoul28/20I2/CHN

28756, 33I6G, 37576

2297 VPI AGJ52I7B 2297 B707 IIII7, 15527, 19937, 24347, norovirus Hu/GI/HuzhouNI0/2008/CHN

28757, 33IB7, 37577

2298 VPI A0085555 2298 B708 IIII8, 15528, 19938, 24348, norovirus Hu/Gllg- 28758, 33IB8, 37578 Glll2/Velence/HUN44I7/20I0/HUN

2299 VPI AFD84D35 2299 B709 HUB, 15529, 19939, 24349. murine norovirus

28759, 33169, 37579

23DD VPI AFND99I8 2300 B7I0 11120, 15530, 19940, 24350. norovirus Hu/GII-4/CGMH0l/200G/TW

287B0, 33170, 37580 230I VPI AFN0992I 230I B7II III2I, I553I, I994I, 2435I, norovirus Hu/G!i-4/CGMHD2/2D0B/TW

287BI, 33I71, 3758I

2302 VPI AFN09924 2302 B7I2 III22, I5532. I9942, 24352, nornvirus Hu/GII-4/CGMH03/20DB/TW

287B2, 33I72, 37582

23D3 VPI AFN09927 2303 B7I3 III23. I5533, I9B43, 24353, norovirus Hu/GII-4/CGMH04/20DB/TW

287B3, 33I73, 37583

2304 VPI AFN09930 2304 B7I4 III24, I5534, I9944, 24354, norovirus Hu/GII-4/CGMH05/200B/TW

287B4, 33I74, 37584

2305 VPI AFN09933 23D5 B7I5 III25, I5535, 19345. 24355, norovirus Hu/GII-4/CGMH0G/200B/TW

287B5, 33175, 37585

2306 VPI AFN0993B 230B B7IB III2B, I553B, I994B, 2435B, norovirus Hu/GII-4/CGMH07/200B/TW

287BB, 33I7B, 3758B

2307 VPI AFN09939 2307 B7I7 11127, 15537, 19947, 24357, norovirus Hu/GII-4/CGMH08/200B/TW

287B7, 33177, 37587

2308 VPI AFND9942 2308 B7I8 11128, 15538, 19948, 24358, norovirus Hu/GII-4/CG H09/200G/TW

287B8, 33178, 37588

2300 VPI AFND9945 2309 B7IB 11123. 15539, 19949, 24359, norovirus Hu/GII-4/CGMHI0/20DB/TW

287B9, 33179, 37589

23I0 VPI AFN09948 23I0 B720 11130. 15540, 19950, 243B0, norovirus Hu/GII-4/CGMHII/200B/TW

28770, 33180, 37590

23II VPI AFN0995I 23II B72I III3I, 15541, 19951, 243B1, norovirus Hu/GII-4/CGMHI2/20D7/TW

28771, 33181.37591

23I2 VPI AFN09954 23I2 G722 11132, 15542. 19952, 243B2, nornvirus Hu/GII-4/CGMHI3/2007/TW

28772, 33182, 37592

23I3 VPI AFN09957 23I3 B723 11133. 15543, 19953, 243B3, norovirus Hu/GII-4/CGMHI4/2007/TW

28773, 33183, 37593

23I4 VPI AFN099B0 23I4 G724 11134, 15544, 19954, 243B4, norovirus Hu/GII-4/CGMHI5/2007/TW

28774.33184, 37594

23I5 VPI AFN099B3 23I5 B725 11135. 15545, 19955, 243B5, norovirus Hu/GII-4/CG HIB/2007/TW

28775, 33185, 37595

23IB VPI AFN0B9BG 23IB G72B III3B, I554B, I995B, 243BB, norovirus Hu/GII-4/CGMHI7/20D7/TW

2877B, 33I8B.3759B

23I7 PI AFN099B9 23I7 G727 11137. 15547, 19957, 243B7, norovirus Hu/GII-4/CGMHI8/2008/TW

28777, 33187, 37597 23I8 VPI AFN09872 23I8 B728 III38. I5548, I3358, 243B8. norovirus Hu/GII-4/CGMHI9/2009/TW

28778, 33I88.37538

23I9 VPI AFN03B75 23IB 6723 IH3e, I554B. IB353, 24363. norovirus Hu/GII-4/CG H20/2009/TW

28773.33I89.37539

232D VPI AFN09978 2320 B73B III40. I5550. I39B0. 24370, norovirus Hu/GII-4/CGMH2l/20IO/TW

28780, 33I30, 37B00

232I VPI AFN0B88I 232I B73I III4I. I555I, I336I, 2437I, norovirus Hu/GII-4/CGMH22/20IO/TW

28781, 33I31, 37B0I

2322 VPI AFND9B84 2322 B732 III42, I5552, I3362, 24372, norovirus Hu/GII-4/CGMH23/20ID/TW

28782, 33132.37602

2323 VPI AFHQ3987 2323 B733 11143. 15553, I33B3, 24373, norovirus Hu/GII-4/GGMH24/20IO/TW

28783, 33193, 37603

2324 VPI AFN0933Q 2324 B734 11144, 15554, 19364, 24374, norovirus Hu/GII-4/CGMH25/20IO/TW

28784, 33134, 37BD4

2325 VPI AFN09393 2325 B735 11145, 15555, 19965, 24375, norovirus Hu/GII-4/CGMH2B/20IO/TW

28785, 33195, 37B05

232B VPI AFN0999B 232B B73B 11146, 15556, 10966, 24376, norovirus Ho/GII-4/CGMH27/20IO/TW

2878B, 33196, 37606

2327 VPI AFN09999 2327 B737 11147, 15557, 19967, 24377, norovirus Hu/GII-4/CGMH28/20IO/TW

28787, 33197, 37607

2328 VPI AGC9B523 2328 B738 11148, 15558, 19968, 24378, norovirus Hu/GII.4/BZ20ID- 28788, 33198, 37608 L26/Guangzhnu/CHN/20I0

2328 VPI AGC96532 2323 B739 11149, 15559, 19969, 24379, norovirus hVGII.4/GZ20!0- 28789, 33199, 37609 L87/Guangzhou/CHN/20II

2330 VPI AGC3B535 2330 B740 III5D, 15560, 19970, 24380, norovirus Hu/GII.B/GZ2DID- 28790, 33200, 37610 L9G/Guangzhou/CHN/20II

233I VPI AGSIBB30 233I B74I III5I, 15561. 19971, 24381, norovirus Hu/GII.4/Guangzhou/GZ2DI0- 28791, 33201, 37611 L88/CHN/20II

2332 VPI AGSIBB33 2332 B742 11152, 15562. 19972. 24382. norovirus Hu/GII.4/Guangzhou/GZ20IO- 28792, 33202, 37612 L9I/CHN/20II

2333 VPI ALM383IB 2333 B743 11153, 15563, 19973, 24383, norovirus Gil

28733, 33203, 37613

2334 VPI ALM38B22 2334 G744 11154, 15564, 13374, 24384, norovirus Gil

28734, 33204, 37614 2335 VPI ALM98928 2335 B745 III55, I5565, I9975, 24385, naravirus Gil

28795.33205, 376I5

233B VPI ALM9803I 233B B74B III5B, I55BB, I997B, 24386, naravirus Gil

28796, 332D6, 376IB

2337 PI ALM98934 2337 B747 III57, I5567, I9977, 24387, norovirus Gil

28797, 332D7, 37BI7

2338 VPI ALM9894D 2338 B748 III58, I55B8, 19378, 24388, naravirus Gil

28788, 33208, 37B18

2339 VPI ALM98943 2339 6749 11159. 15569, 19979, 24389, naravirus Gil

28799, 33209, 37619

234D VPI ABD7393B 234D B75D 11160, 15570, 19980. 24390. naravirus Hu/GII/Carlow/20D2/lre

28800, 33210, 37B20

234I VPI ABYB7257 234I B75I IIIBI, 15571, 19981. 24391, naravirus Bo/GIII.I/Aba-Z5/2002/H0N

28801, 33211, 37621

2342 VPI AHA9IB5B 2342 B752 IIIB2, 15572, 19982, 24392, naravirus GI.9

28802, 33212, 37622

2343 VPI BALBD747 2343 B753 11163, 15573, IB983, 24393, naravirus Hu/GII.2/DC0504l/2005/JP

28803, 33213, 37623

2344 VPI BALBD75I 2344 B754 11164, 15574, 19984, 24394, naravirus Hu/GII.2/0C05l43/2005/JP

28804, 33214, 37624

2345 VPI BALB07B3 2345 B755 11165, 15575, 19985, 24395, naravirus Hu/GII.2/0C07l07/2007/JP

28805.33215, 37625

234B VPI BALBD7B5 234B B75B 11166, I557B, 19986, 24396, naravirus Hu/GII,2/0C08079/20D8/JP

2880B, 332IB, 3762B

2347 VPI BALBD787 2347 B757 IIIB7. 15577, 19987, 24397. naravirus Hu/GII.2/0C09072/20D9/JP

28807.33217, 37B27

2348 VPI BALBD789 2348 B758 IIIB8, 15578, 19988, 24398, noravirus Hu/GII.Z/DCD9D94/2DD9/JP

28808, 33218, 37628

2349 VPI BALBD8D7 2349 6759 11169, 15579, 19989, 24399, norovirus Hu/GII.2/OCI0058/20IO/JP

28809, 33218.37629

235D VPI ACLI4997 235D B76D 11170, 15580, 19990, 24400, naravirus

28810, 33220, 37B30 Hu/GII/2005/6675/ChBlyabinsk/RUS

235I VPI ACB5B49D 235I 676I III7I, 15581, 19991, 24401, norovirus Hu/GII-4/Beijingl5l/2DD7/China

28811, 33221, 37B3I 2352 VPI ACF77ID6 2352 6762 III72, I5582, I3932, 24402, norovirus Hu/GII.4/BJ222/2008/CHN

288I2.33222.37632

2353 VPI ACF77I07 2353 6763 III73. 15583, I9393, 24403, noravirus Hu/BII.4/BJZ25/2D0B/CHM

288I3, 33223, 37633

2354 VPI ACU288D7 2354 6764 III74, I5584, I3934, 24404, norovirus Hu/GII.4/H /CU09N7 20D9/CHN

288I4, 33224, 37634

2355 VPI ACU288D8 2355 6765 III75, I5585, I3395, 24405, norovirus Hu/GII.4/HK/CUDBNB/ZDD9/CHN

288I5. 33225, 37635

2356 VPI ACV03476 2356 6766 III76, I5586, I9996, 24406. nurovirus Hu/GII.4/Tianjin/75/2008/CHN

288I6, 33226, 37636

2357 VPI ACV03479 2357 6767 III77, I5587, I3337, 24407, noravirus Hu/GII/Tianjin/510/2003/CHN

288I7, 33227, 37637

2358 VPI AFN70960.I 2358 6768 III78, 397I7, I5588, IB938, norovirus Hu/GII.4/03l6B3/USA/2003

24408, 28818, 33228, 37638

235B VPI X8I879 2353 676S 11179, I558B, 13933, 24403, human calicivirus strain Melkshsm

28819, 33229, 37639

2360 VPI FJ875D27 2360 6770 11180, 15530, 20000, 24410, norovirus dog/GVI.I/Bari/BI/2007/ITA

28820, 33230, 37640

23GI VPI JFB39D46 236I 677I III8I, 15591. 20001, 24411, norovirus dog/FD2IO/2007/lta

28821, 33231, 37641

2362 VPI JF93D689 2362 6772 11182, 15592, 20002, 24412, norovirus dog/FD53/2007/lta

28822, 33232, 37642

2363 VPI GQ4436II 2363 6773 11183, 15593, 20003, 24413, norovirus dog/C33/Viseu/2007/PRT

28823, 33233, 37643

2364 VPI EU224456 2364 6774 11184, 15594, 20004, 24414, norovirus dog/170/07/lta

28824, 33234, 37644

2365 VPI EF45Q827 2365 6775 11185, 15595, 20005, 24415, nurovirus lion/GIV.2/Pistoia/387/06/ITA

28825, 33235, 37645

2366 VPI JF78I268 2366 6776 11186, 15596, 20006, 24416. norovirus cat/GIV.2/CU08l2IDE/USA/20IO

28826, 33236, 37646

2367 VPI T245I36 2367 6777 11187. 15597, 20007, 24417, norovirus cat/GVI,2/TE/77-l3/ITA

28827, 33237, 37647

2368 VPI AJ844470 2368 6778 11188. I55B8, 20008, 24418, Norwalk virus

28828, 33238, 37648 Hu/NV/Chiba/040502/2004/JP 2369 VPI JI9B29I 23G9 G779 11189, 15599, 20009, 244IB, norovirus

28829.33239, 37649 GII/Hu/JP/2QII/GII/Yuzawa/Gira2HS

2370 VPI U87G455 237Q G780 11190. I5G00, 20010. 24420. narnvirus GII.B

28830. 33240, 37650

2371 PI AF4I44D8 2371 G78I III9I, 15601, 20011, 24421, Horwalk-like virus

28831, 33241, 37651 HLV/Baltimore/274/1333/OS

2372 VPI ABD8407I 2372 6782 11192. 15602, 20012, 24422, Horwalk-like virus

28832.33242, 37652

2373 VPI AF4I44Q7 2373 G783 11193, 15603, 20013, 24423. Horwalk-like virus NLV/Florida/2B9/1993/0S

28833, 33243, 37653

2374 VPI AB039777 2374 6784 11134. I5B04, 20014, 24424, Norwalk-like virus

28834. 33244, 37654

2375 VPI AB078337 2375 6785 11195, 15605, 20015, 24425, Norwalk-like virus

28835, 33245, 37G55

237G VPI ABD3977G 237G 6786 11196, I5B06, 20016, 24426, Horwalk-like virus

2883B, 3324B, 37B56

2377 VPI KT030G74 2377 6787 11197. 15607, 20017. 24427. norovirus GIV.I

28837, 33247, 37657

2378 VPI DQG93QG7 2378 6788 11198, 15608, 20018, 24428, Horwalk virus

28838, 33248, 37B58

2379 VPI AFI95847 2379 6789 11199. I5B09. 2D0I9. 24423. human norovirus - Alphatron

28833, 33243, 37653

2380 VPI JQ97Q479 238D 6790 11200, 15610, 20020, 24430, norovirus Hu/GIV.I/Ahrensh.Dp246/DE0/2QI2

28840, 33250, 376B0

2381 VPI FM8G54I2 2381 6791 IIZDI. I5BII, 20021, 24431, norovirus Hu/GIV.I/ltaly/B80/2OO7/ITA

28841. 33251, 37661

2382 VPI AF4I442G 2382 G792 11202, 15612, 20022, 24432. Horwalk-like virus NLV/Fort

28842, 33252, 37BB2 Laud _B rdale/5B0/IS98/US

2383 VPI AF4I4427 2383 G7B3 11203, 15613. 20023, 24433, Horwalk-like virus HLV/Saint

28843, 33253, 376B3 Cloud/B24/l338/US

2384 VPI JQGI35G7 2384 B7B4 11204, 15614, 20024, 24434. norovirus

28844, 33254, 37664 Hu/GIV.I/LakeMacquarie/HSW2680/20IO/AO

2385 VPI KC89473I 2385 G795 11205, 15615, 20025, 24435, norovirus Hu/GIV.I/CCDC GRIII3-59/CHN/20II

28845, 33255, 37665 2386 VPI AF427II8 2386 B79B II206, I56IB, 20026, 2443B, human calicivirus NLV/Erfurt/546/D0/DE

28846, 33256, 37BBB

2387 VP! AY2374I5 2387 6797 II2D7, I56I7, 20027, 24437, human calicivirus strain Mc37

28847, 33257, 37B67

2388 VPI AF50467I 2388 B798 II208, I56I8, 20028, 24438. Norwalk virus

28848, 33258, 37668

2389 VPI KJ1345D4 2389 6799 H209. I56I9, 20029, 24439, nuravirus Hu/GII/Amsterdam/1994

28849, 33259, 37669

2390 VPI JI94500 2390 6800 11210, 15620, 20030, 24440, norovirus Hu/GII/Amsterdam/l/1995

28850, 3326D, 37670

230I VPI D0093063 239I 680I II2II, 15621, 20031, 24441, Norwalk virus

28851, 33261, 37B7I

2392 VPI AY0303I3 2392 6802 11212, I5B22. 20032, 24442, human calicivirus Hu/NLV/GII/MDI34- 28852, 33262, 37672 I0/I987/0S

2393 VPI 002030 2393 B803 11213. 15623, 20033, 24443, minireovirus

28853, 33263, 37673

2394 VPI AB039782 2394 B804 11214, 15624, 20034, 24444, Norwalk-Itke virus

28854. 33264, 37674

2395 VPI 046039 2395 B805 11215, 15625, 20035, 24445, small round structured virus

28855, 33265, 37B75

2396 VPI 00093066 2396 68D6 II2IB, I5B2B, 2D03B, 24446, Norwalk virus

28856, 33266, 37676

2397 VPI D0093062 2397 6807 11217, 15627, 20037, 24447, Norwalk virus

28857, 332B7, 37B77

2398 VPI G0930737 2398 6808 11218, 15628, 20038, 24448, Norwalk-like virus

28858, 33268, 37678

2399 VPI AF4I44I2 2399 B8D9 11219, 15629, 20039, 24449, Narwalk-like virus NLV/NBW

28859, 33269, 37679 0rleans/27e/l994/0S

2400 VPI AB03978I 240D 68I0 11220, 15630, 20040, 24450, Norwalk-like virus

28860.33270. 37680

24DI VPI LC035073 240I 68II 11221, 15631. 2D04I. 24451. norovirus Hu/GII/l4-2523/Tokyo/20l4/JPN

28861, 33271, 37B8I

2402 VPI AF539440 2402 68I2 11222, 15632, 20042, 24452, human calicivirus NLV/Oberhausen 455/DI/DE

28862, 33272, 37682 2403 VPI AF4I44I4 2403 B8I3 11223, 15633, 20043, 24453, Norwalk-like virus NLV/TnwsDn/3l3/IB94/US

28863, 33273, 37683

2404 VPI ABI90457 2404 B8I4 11224, 15634, 20044. 24454, Norwalk virus

28864, 33274, 37684

2405 VPI AF4257B8 2405 B8I5 11225, 15635, 2D045, 24455, human calicivirus NLV/Oberhausen 455/01/DE

288B5, 33275, 37B85

240G VPI AF4I44I5 240B 6816 11226, 15636, 20046, 24456, Norwalk-like virus

28866, 33276, 37686 NLV/Brattleboro/321/1995/liS

2407 VPI T779557 2407 6817 11227, 15637, 2D047, 24457, norovirus Bll

288B7, 33277, 37687

2408 VPI AY247432 2408 6818 11228, 15638, 20048, 24458, human calicivirus NLV/2004-D0/SWE

28868, 33278, 37688

2409 VPI AF4I44I! 2409 6819 11229, 15639, 20049, 24459, Norwalk-like virus NLV/Lionville/247/1993/OS

28869, 33279, 37689

2410 VPI AJ277BI7 2410 6820 11230, 15640, 20050, 24460, human calicivirus HU/NLV/lh/93/O

28870, 33280.37690

2411 VPI LCB3B5BI 2411 6821 11231. 15641, 20051. 24461, norovirus Hu/Bll/I4-3I7D/Wyo/20I4/JPN

28871, 33281, 37G9I

2412 VPI KT732274 2412 6822 11232, I5B42, 20052, 244B2, norovirus GII.3

28872, 33282, 37692

2413 VPI AY247430 2413 6823 11233, 15643, 20053, 244G3, human calicivirus NLV/II57-0I/SWE

28873, 33283.37693

2414 VPI AF539439 2414 6824 11234, 15644. 20054, 244B4, human calicivirus NLV/Herzberg 385/OI/DE

28874, 33284, 37694

2415 VPI AF4I44I3 2415 6825 11235, 15645, 20055, 24465, Norwalk-like virus

28875, 33285, 37695 NLV/Montgomery/312/1994/US

24IB VPI AF427II2 24IB 6826 11236, I564B, 20056, 244BB, human calicivirus Hu/NLV/Bitburg/289/OI/DE

28876, 33286, 37696

2417 VPI AFI908I7 2417 6827 11237. 15647, 20057. 24467, human calicivirus strain Arg320

28877, 33287, 37697

2418 VPI LC035072 2418 6828 11238, 15648, 20058. 24468, norovirus Hu/GII/l4-2397/ yo/20l4/JPN

28878, 33288.37698

2419 VPI DD0930B4 2419 6829 11239, 15649, 20059, 24469, Norwalk virus

28879, 33289, 37699 2420 PI L2383D 2420 B830 11240, I5B50, 200B0, 24470, Norwalk virus

28880, 33290.37700

2421 VPI KX907728 2421 B83I 11241, I5B5I, 200BI, 24471, norovirus Hu/0SA/20IB/GIV.3/WI7002

28881, 33291, 37701

2422 VPI ABD39779 2422 B832 11242, I5B52, 200B2, 24472, Norwalk-like virus

28882, 33292, 37702

2423 VPI AB039778 2423 B833 11243, I5B53, 2D0B3, 24473, Norwalk-like virus

28883, 33293, 37703

2424 VPI KY424345 2424 B834 11244, I5B54, 200B4, 24474, norovirus GII.B

28884, 33294, 37704

2425 PI HQI69542 2425 B835 11245, I5B55, 20QB5, 24475, noravirus Hu/GII.B/f SB/2DD5/USA

28885, 33295, 377D5

2426 VPI KX228762 242B B83B II24B, I5B5B, 200BB, 2447B, norovirus sp.

2888B, 3329B.3770B

2427 VPI AF4I44ID 2427 B837 11247, I5B57, 200B7, 24477. Norwalk-like virus NLV/Miami/292/1994/US

28887, 33297.37707

2428 VPI KU93573B 2428 B838 11248, I5B58, 200B8, 24478, norovirus Gil

28888, 33298, 37708

2429 VPI KX268709 2429 B839 11249, I5B59, 200B9, 24479, norovirus

28889, 33299, 37709 Hu/GM.P7_GII.B/Maryland/2D!4/USA

2430 VPI KXI58282 2430 B84D 11250, I5BB0, 2D070, 24480, norovirus Gil

28890, 3330D, 37710

2431 VPI ABI2B32D 2431 B84I 11251, I5BBI, 20071, 24481, Norwalk-like virus

28891, 33301, 37711

2432 VPI AYD77B44 2432 B842 11252. I5BB2, 20072, 24482, Norwalk-like virus Sw/NLV/VA34/I998/NL

28892, 33302, 37712

2433 VPI AY8233DB 2433 B843 11253, I5BB3, 20073, 24483, norovirus swine/GII/0H-QWI70/03/US

28893, 33303, 37713

2434 VPI F58B5D8 2434 B844 11254, I5BB4, 20074, 24484, norovirus GI.9

28894, 33304, 37714

2435 VPI HQB372B7 2435 B845 11255, I5BB5, 20075, 24485, norovirus Hu/GI/Vancouver730/2004/CAN

28895, 33305, 37715

243B VPI AYI34748 243B B84B II25B, I5BBB, 2007B, 2448B, snow mountain virus

2889B, 333DB, 377IB 2437 VPI AYD543DD 2437 B847 11257, I5BB7, 20077, 24487, human caiicivirus

28897, 33307, 37717 NLV/Chesterfield/434/1997/US

2438 VPI KY485I25 2438 B848 11258, I5BB8, 2D078, 24488, norovirus IBF2l49_GII.2_Guangdong_CHN_201G

28898, 33308, 37718

2430 VPI Y485I23 2439 B849 11259, I5BB9, 20079, 24489, noruvirus

28899, 33309, 37719 l6SF2ll34_BII.2_GuangdDng_CHN_2DI6

244D VPI Y485I2B 2440 B850 11260. 15G70, 20080, 24490, norovirus l6F2l6l_GII.2_Guangdong_CHN_20l6

2890D, 33310, 37720

2441 VPI U70059 2441 B85I II2BI, 15671, 20081, 24491, snow mountain virus

28901, 33311, 37721

2442 VPI LCI458D8 2442 B852 11262, 15672, 20082, 24492, norovirus Hu/GII.2/Ehime5_20l4_JP

28902, 33312, 37722

2443 VPI LCI45795 2443 B853 11263. I5B73, 20083. 24493. norovirus Hu/GII.2/Hirashimacityl_20l2_JP

28903.33313.37723

2444 PI ABB2994I 2444 B854 11264, I5B74, 20084, 24494, norovirus Hu/Tokyo/IO-14/2010/JPN

28904, 33314, 37724

2445 VPI LCI45792 2445 B855 11265. I5B75. 20D85, 24495, norovirus Hu/GII.2/Saitama5_20l2_JP

28005, 33315, 37725

2446 VPI LCI4578B 244B B85B 11266, I5B7B, 2008B, 2449B, norovirus Hu/GII.2/AkitaB_2DI2_JP

28006, 33316, 37726

2447 VPI LCI45793 2447 B857 11267. I5B77, 20087, 24497, norovirus Hu/GII.2/Dsakacity5_20l2_JP

28907, 33317, 37727

2448 VPI LCI4579I Z448 B858 11268. 15B78, 20088, 24498, norovirus Hu/GII.2/Saitama4_20l2_JP

28908, 33318, 37728

2449 VPI LCI45788 2449 B859 11269. 15679. 20089, 24499, norovirus Hu/GII.2/Niigata5_20l2_JP

28909, 33319, 37729

2450 VPI LCI45803 2450 B8B0 11270, I5B80, 20090, 24500, norovirus Hu/GII.2/0saka5_20l4_JP

28910, 33320, 37730

2451 PI LCI458D4 2451 B8BI 11271, 15681, 20091, 24501, norovirus Hu/GII.2/Hiroshim3B_20l4_JP

28911, 33321, 37731

2452 VPI LBI4580I 2452 B8B2 11272, 15682, 20092, 24502, norovirus Hu/GII.2/ iyagi2_20l4_JP

28912, 33322, 37732

2453 VPI LBI45802 2453 B8B3 11273, 15683, 20093, 24503, oorovirus Hu/GII.2/Dsaka4_2DI4_JP

28913, 33323, 37733 2454 VPI LCI458D5 2454 6864 11274. 15684, 20094, 24504, norovirus Hu/GII.2/Hiroshimacity5_20l4_JP

28914, 33324, 37734

2455 VPI LCI45797 2455 68B5 11275, 15685, 20095, 24505, norovirus Hu/BII.2/Ehime2_20l2_JP

28915, 33325, 37735

245B VPI LCI45806 245B 686B IIZ76, I5B8B, 2009B. 245D6. norovirus Hu/GII.2/Hiroshimacity6_20l4_JP

28916, 33326, 37736

2457 VPi KU30B738 2457 B867 11277, 15687, 20097, 24507, norovirus Gil

28917, 33327, 37737

2458 VPI M03G380 2458 6868 11278, 15688, 20098, 24508, norovirus Hu/GII.PIB/GII.I3/New/Taipei/l3- 28918, 33328, 37738 BA-I/20I3/TW

2458 VPI AYII3ID6 2459 6869 11279, 15689, 20009, 2450B, Norwalk-like virus

28919, 33329, 37739

24BD PI ABD78334 246D 6870 11280, 15690, 20100, 24510, Narwalk-like virus

28920, 33330, 37740

2461 VPI K 28BI72 2461 6871 11281, 15691, 20101, 24511, norovirus Hu/PV_VoelkOOI8/20l3/DEU

28921, 33331, 37741

2462 VPI AYI3D762 2462 6872 11282, 15692, 20102, 24512, human calicivirus NLV/J23/I999/0S

28922, 33332, 37742

2463 VPI KJI96290 2463 B873 11283, 15693, 20103, 24513, norovirus

28923, 33333, 37743 GII/Hu/JP/2007/GII.PI5_GII.I5/Sapporo/H 2

99

2464 VPI G0856474 2464 B874 11284, 15694, 20104, 24514, norovirus Hu/Gll.4/Beijing/55I6I/2D0B/CHN

28924, 33334, 37744

2465 VPI LCI45787 2465 6875 11285. 15695, 20105. 24515, norovirus Hu/GII.2/Miyagil_20l2_JP

28925.33335, 37745

2466 VPI AB629946 2466 6876 11286. 15696, 20106, 245IG, norovirus Hu/Tokyo/IO-4320/2011/JPN

28926, 33336, 37746

2467 VPI KT962983 2467 6877 11287, 15697, 20107, 24517. norovirus GII.2

28927, 33337, 37747

2468 VPI ABD8378D 2468 6878 11288, 15698, 20108, 24518, Norwalk-like virus

28928, 33338, 37748

2469 VPI KX98784D 2469 B879 11289, I5B99, 20109, 24519, murine norovirus

28929, 33339, 37749

247D VPI R349276 2470 6880 11290, I570D, 20110, 24520, murine norovirus

28930, 33340, 37750 2471 VPI MID244B 2471 6881 11291, 15701. 20111, 24521, murine nurovirus GV/WU20/2005/0SA

28931, 33341, 37751

2472 VPI KC792553 2472 6882 II2B2, 15702, 20112, 24522, murine nurovirus 3

28932, 33342, 37752

2473 VPI AB80999I 2473 6883 11293, 15703, 20113, 24523. nurovirus Hu/GII.I3/09N3698/2Q09/NP

28933, 33343, 37753

2474 VPI AB8D999D 2474 6884 II2B4, 15704, 20114, 24524, noruvirus Hu/GII.I3/09N3688/2003/NP

28934, 33344, 37754

2475 VPI AB8D9977 2475 6885 11295, 15705, 20115, 24525, norovirus Hu/GII.I3/09N3l80/2009/NP

28935, 33345, 37755

2476 PI AB8D9987 2476 6886 11296, 15706, 20116, 24526, noruvirus Hu/GII.I3/09N3BI7/2009/NP

28936, 33346, 37756

2477 VPI AJ844469 2477 6887 11297, 15707, 20117, 24527, Norwalk virus Hu/NV/Chiba/030IOO/20D3/JP

28937, 33347, 37757

2478 VPI AY675555 2478 6888 11298, 15708, 20118, 24528, norovirus NLV/IF2D3B/2003/lraq

28938, 33348, 37758

2479 VPI EUD85479 2479 6889 11299, 15709, 20119, 24529, norovirus Hu/GII/PI.Cnnfectianary2004/

28939, 33349, 37759 Gothenburg/Sweden

248D VPI AF54209D 248D 6890 II30D, 15710, 20120, 24530, human calicivirus NLV/Mex707B/l999

28940, 33350, 37760

2481 VPI M38B68D 2481 6891 11301, 15 ^* 711, 20121, 24531, norovirus 07-AF-I/2007/GII.P22/GII.5

28941, 33351, 37761

2482 VPI AF397I56 2482 6892 11302, 15712, 20122, 24532, human calicivirus NLV/MOH/99

28942, 33352, 37762

2483 VPI AF4I4422 2483 6893 11303, 15713, 20123, 24533, Nnrwalk-like virus NLV/NBW

28343, 33353, 37763 0rleans/30B/l994/0S

2484 VPI AF4I4423 2484 6894 11304, 15714, 20124, 24534, Norwalk-like virus NLV/White

28944, 33354, 37764 I 290/I994/0S

2485 VPI GQ85647G 2485 6895 11305, 15715, 20125, 24535, norovirus Hu/GII.4/Beijing/55l7l/2008/CHN

28945, 33355, 37765

2486 VPI AJ2776D7 2486 6896 11306, 15716, 20126, 24536, human calicivirus HU/NLV/Hillingdon/90/OK

28946, 33356, 37766

2487 VPI AY77273D 2487 6897 11307, 15717, 20127, 24537, norovirus

28947, 33357, 37767 Hu/NLV/BII/Neustrelitz2B0/200O/DE 2488 VPI KT3I57I8 2488 B898 11308, 15718, 20128. 24538, norovirus Hu/BII.I7/CUH -NS-B7D/H G/ZDI5

28948, 33358, 377B8

2489 VPI KT3I5708 2489 B899 11309, 15719, 20129, 24539, norovirus Hu/BII.I7/CUHK-NS-B49/HKB/20l5

28949, 33359, 377B9

249D VPI KT3I5B97 2490 BBOO 11310, 15720. 20130. 24540. norovirus Hu/BII.I7/CUH -NS-BIB/HKG/ZDI5

28950, 33360, 37770

2491 VP! KT3I5689 2491 B9DI II3II, 15721, 20131, 24541, norovirus Hu/GII.I7/CUHK-NS-B00/HKG/20l5

28951, 333BI, 37771

2492 VPI KX2I6805 2492 6902 11312, 15722. 20132. 24542, norovirus Gil

28952, 333B2, 37772

2493 VPI KU557859 2493 B903 11313, 15723, 20133, 24543, norovirus Hu/GII.I7/34-057G/GD-DG/2OI5- 28953, 33363, 37773 03-27

2494 VPI K0557828 2494 6904 11314, 15724, 20134. 24544, norovirus Hu/GII.I7/20-l695/GD-JM/20l4-l2- 28954, 33364, 37774 25

2495 VPI KT3I5B92 2495 6905 11315, 15725, 2DI35, 24545, norovirus Hu/GII.I7/CUHK-NS-604/HKG/20l5

28955, 33365, 37775

2496 VPI XIB8437 249B 6906 11316. 15726, 20136, 24546, norovirus GII.I7

28956, 33366. 37776

2497 VPI KXI68440 2497 6907 11317, 15727, 20137, 24547, norovirus GII.I7

28957, 33367.37777

2498 VPI KX2IB793 2498 6908 11318, 15728, 20138. 24548. norovirus Gil

28958, 33368, 37778

2499 VPI U55788I 2499 6900 11310, 15729, 20139, 24549, norovirus Hu/GII.I7/5-0032/GD-ZH/20l5-0l- 28959, 333B9, 37779 10

25D0 VPI Y424350 2500 6910 11320, 15730, 20140, 24550, norovirus GII.I7

289B0, 33370, 37780

25DI VPI U557884 2501 B9II 11321, 15731, 2DI4I, 24551. norovirus Hu/GII.I7/52-l8l9/GD-GZ/20l5-ll- 289BI, 33371, 37781 09

25D2 VPI U5BI253 2502 6912 11322, 15732, 20142, 24552, norovirus GII.I7

289B2, 33372. 37782

25D3 VPI KP902588 2503 6913 11323. 15733. 20143. 24553, norovirus Hu/BII.I7/H G/2BI5/CUH -NS-5B5

289B3, 33373. 37783

2504 VPI KXIB845B 25D4 6914 11324. 15734, 20144, 24554, norovirus GII.I7

28964, 33374, 37784 25D5 VPI XIG8444 2505 G9I5 11325, 15735, 20145, 24555, norovirus Gil.17

28965, 33375, 37785

25DB VPI KXZIG80G 250G G9IG 11326, 15736, 20146, 2455B, narovirus Gil

289BB, 33376, 37786

25D7 VPI KX2IG794 2507 B9I7 11327, 15737, 20147, 24557, norovirus Gil

289G7, 33377, 37787

2508 VPI KX420895 2508 6918 11328, 15738. 20148, 24558, norovirus GII.I7

28968, 33378, 37788

2509 VPI KT59I50I 2509 B9I9 11329, 15739. 20149, 24559. narovirus

28969, 33379, 37789 GII/Hu/SI/20l5/GII.I7/Ljubljanal662

2510 VPI KT3I57I4 2510 G92D 11330, 15740, 20150, 24560, norovirus Hu/GII.I7/C0HK-NS-658/HKG/20l5

28970.33380, 37790

2511 VPI T3I5G73 2511 G92I 11331. 15741. 20151, 24561, norovirus Hu/GII.I7/CUH -NS-486/HKG/20l4

28971, 33381, 37791

2512 VPI KX2IG792 2512 G922 11332, 15742, 20152, 24562, norovirus Gil

28972, 33382, 37792

2513 VPI K0953398 2513 B923 11333, 15743, 20153, 24563, norovirus GII.I7

28973, 33383, 37793

2514 VPI KU557888 2514 B924 11334, 15744, 20154, 245B4, norovirus Hu/GII.I7/7-0057/GD-ZH/20l5-0l- 28974, 33384.37794 05

2515 VPI KU557808 2515 B925 11335, 15745, 20155, 245G5, norovirus Hu/Gll.l7/I5-I650/GD-DY/20I4-I2- 28975, 33385, 37795 18

25IG VPI KU557807 25IG G926 11336, 15746, 20156, 24566, norovirus Hu/Gll.l7/I5-I649/G0-0Y/20I4-I2- 28976, 33386, 37796 19

2517 VPI KX37IIII 2517 6927 11337, 15747, 20157, 245B7, norovirus GII.I7

28977, 33387.37797

2518 VPI KX37III0 2518 G928 11338, 15748, 20158, 24568. norovirus GII.I7

28978, 33388, 37798

2519 VPI KXI34669 2519 B929 11339, 15749, 20159, 24569, norovirus GII.I7

28979, 33389, 37799

2520 VPI KU55787I 2520 6930 11340, 15750, 20IG0, 24570, norovirus Hu/GII.I7/4-OOI9/GD-HZ/20l5-OI- 28980, 33390, 37800 09

2521 VPI KX37II08 2521 6931 11341, 15751, 20161, 24571, norovirus G 11.17

28981, 33391, 37801 2522 VPI U557829 2522 B932 11342, 15752, 20162, 24572, noravirus Hu/GII.I7/20-l7ll/GD-JM/20l4-l2- 28982, 33392, 37802 26

2523 VPI XIG8452 2523 B933 11343, 15753, 20163, 24573, noravirus GII.I7

28983.33393, 37803

2524 VPI KU953393 2524 6934 11344, 15754, 20164, 24574, noravirus 011.17

28984, 33394, 37804

2525 VPI 05202D 2525 B935 11345, 15755, 20165, 24575, noravirus Hu/GII.I7/Changhua/l5-AH- 28985, 33395, 37805 I/20I5/TW

2526 VPI T3I5B87 252B 693B 11346, 15756, 20166, 2457B, noravirus Hu/GII.I7/CUHK-NS-593/HKG/20l5

28986, 33396, 37806

2527 VPI KX356908 2527 6937 11347, 15757, 20167, 24577, noravirus GII.I7

28987, 33397, 378D7

2528 VPI X024652 2528 B938 11348, 15758, 20IB8, 24578, narovirus GII.I7

28988, 33398, 37808

2529 VPI T3I57DB 2529 B939 11349, 15759, 2DIB9, 24579, noravirus Hu/GII.I7/CUHK-NS-G47/HKG/20l5

28989, 33399, 378D9

253D VPI KXI34B7G 2530 6940 11350, 15760, 20170, 24580, noravirus GII.I7

28990, 33400, 37810

2531 VPI T78D39B 2531 6941 11351, 15761, 2DI7I, 24581, noravirus Hu/GII.I7/CUHK-NS-5D2/HKG/20l4

28991.33401, 37811

2532 VPI P9D2577 2532 B942 11352. 15762. 20172. 24582, noravirus Hu/GII.I7/HKG/20l4/CUHK-NS-502

28992, 33402, 37812

2533 VPI KU587B28 2533 B943 11353, 15763, 20173, 24583, narovirus GII.I7

28903, 33403, 37813

2534 VPI AF4I44DB 2534 6944 11354, 15764, 20174, 24584, Narwalk-like virus

28994, 33404, 37814 NLV/GwynBdd/273/1994/US

2535 VPI KT9435B4 2535 6945 11355, 15765, 20175, 24585, noravirus TF3/0SA/2008

28995, 33405, 37815

253B VPI T9435B5 253B 6946 11356, I576B, 20I7B. 24586. narovirus TF4/USA/2D08

28996, 33406, 37816

2537 PI T9B2982 2537 6947 11357, 15767. 20177, 24587, narovirus GII.2I

28997, 33407, 37817

2538 VPI KXD79488 2538 6948 11358, 15768, 20178, 24588, noravirus GII.2I

289B8, 33408, 37818 2539 VPI KR92I938 253B BB43 11359, I57BB, 20179. 24589, nornvirus Hu/GII.2l/CUHK-NS-5BI/HKG/2GI5

28999, 33403, 37813

254D VPt KR92I940 2540 G950 11360, 15770, 20180, 24530, narovirus Hu/GII.2l/CUHK-NS-6D9/HKG/20l5

23000, 33410, 37820

2541 VPI DQ35S209 2541 B95I II3GI, 15771, 20181, 24531. synthetic construct

23001, 33411.37821

2542 VPI KP784G94 2542 B952 11362, 15772, 20182, 24532, narovirus

23002, 33412, 37822 GII/Hu/ZAF/2D12/GII.P4_GII.4/EmpangBni/86

04

2543 VPI KX3540G4 2543 B953 11363, 15773, 20183, 24533, nornvirus GII.4

29003. 33413, 37823

2544 VPI LCI77G58 2544 B954 11364, 15774, 20184. 24594. narovirus GII.4

23004, 33414, 37824

2545 VPI KX5I4232 2545 B955 11365, 15775, 20185, 24595, narovirus GII.4

23005, 33415, 37825

254G VPI LCI45787 254G G95G 11366, I577G, 20186, 24536, norovirus Hu/GII.2/Miyagil_2DI2_JP

23006, 33416, 37826

2547 VPI KT9G2983 2547 G957 11367, 15777. 20187, 24597, narovirus GII.2

23007, 33417, 37827

2548 VPI ABG2994G 2548 6958 11368, 15778, 20188. 24538, narovirus Hu/Tokyo/I0-4320/20II/JPN

29008.33418, 37828

2549 VPI AB8099B3 2549 B959 11363, 15773, 20189, 24533, norovirus Hu/GII.I3/03N375l/2009/NP

23003, 33413.37823

2550 VPI JQ743330 2550 B9B0 11370, 15780, 20130, 24600, norovirus Hu/GI.3/1999

23010, 33420, 37830

2551 VPI AF4392G7 2551 B9GI 11371. 15781. 20191, 24601, human calicivirus NLV/Potsdam 196/2000/DE

29011, 33421, 37831

2552 VPI EF547393 2552 B9G2 11372, 15782, 20192, 24602, narovirus Hu/0saka/0l03l4/200l/JP/3634

29012, 33422, 37832

2553 VPI AFI45709 2553 6963 11373, 15783, 20193, 24603, human calicivirus NLV/Stav/95/Nor

29013.33423, 37833

2554 VPI FJ7IIIG3 2554 6964 11374, 15784. 20194, 24604, norovirus Hu/GI.3/JKPG_88l/SWE/2007

29014, 33424, 37834

2555 VPI FJ7IIIG4 2555 6965 11375, 15785, 20195, 24605, norovirus Hu/GI.3/JKPG_883/SWE/2007

29015, 33425.37835 2556 VPI AF4I4405 2556 6966 II376, I5786, 20I96, 2460G. Nnrwalk-like virus NLV/Little

290I6, 33426. 37836 Rock/316/1994/US

2557 VPI ABD22679 2557 6967 II377, I5787. 20I97, 24607. chiba virus

290I7. 33427. 37837

2558 VPI AF4I44D3 2558 6968 II378. I5788, 20I98, 24608. Nnrwalk-like virus NLV/Hanolulu/219/1992/OS

290I8. 33428. 37838

2559 VPI LCIDI82I 2559 6969 11379. 15789, 20199. 24609. narQvirus GI/Hu/Jp/20l3/GI.4/sl30149

29019, 33429, 37839

256D VPI AY038598 256D 6970 11380. 15790, 202D0. 24610, human calicivirus NLV/VA98II5/I998

29020. 33430, 37840

25GI VPI KJI96292 256I 697I 11381. 15791, 20201, 24611, noruvirus

29021, 33431. 37841 GI/Hu/JP/2007/GI.P3_GI.3/Shimizu/K 2866

2562 VPI JQ74333I 2562 6972 11382. 15792, 20202, 24612, naruvirus Hu/GI.4/2000

29022. 33432, 37842

2563 VPI EF547394 2563 6973 11383, 15793, 20203, 24613, noravirus Hu/Saga/0003l3/200D/JP/2876

29023, 33433. 37843

2564 VPI AF39496D 2564 6974 11384. 15794, 20204, 24614, human calicivirus

29024, 33434, 37844 H0/NLV/Koblenz/433/2000/DE

2565 VPI AJ2776I6 2565 6975 11385, 15795, 20205, 24615, human calicivirus HO/NLV/ValEtta/95/Malta

29025, 33435, 37845

2566 VPI GQ4I397D 2566 6976 11386, 15796, 20206, 24616. naruvirus Hu/GI.4/IG43/2008/US

29026, 33436, 37846

2567 VPI KT73228I 2567 6977 11387, 15797, 20207, 24617, nuravirus GI.4

29027, 33437, 37847

2568 VPI AF4I44D4 2568 6978 11388, 15798, 20208, 24618, Nnrwalk-like virus

29028, 33438, 37848 NLV/Baltimore/277/1993/US

2569 VPI AF4I44D2 2569 6979 11389, 15799. 20209. 24619, Nnrwalk-like virus NLV/NBW

29029, 33439, 37849 Orleans/266/1993/OS

2570 VPI AJ3I3D3D 257D 6980 11390, 15800. 0210, 24620, human calicivirus Hu/NLV/Queen's

29030, 33440, 37850 Arms/Leeds/92/OK

257I VPI KM03G38I 257I 698I 11391, 15801, 20211. 24621, nnruvirus l4-H-2/20l4/GI.P4/GI,4

29031, 33441, 37851

2572 VPI LN854563 2572 6982 11392, 15802, 20212, 24622. nnrovirus GI/Hu/NL/20ll/GI.4/Groningen

29032, 33442, 37852 2573 VPI ABD42808 2573 B983 11393. I58D3, 2D2I3, 24623, chiba virus

29G33, 33443, 37853

2574 VPI EUB04B79 2574 B984 11394, 15804. 2D2I4, 24B24, murine norovirus GV/C II/2005/USA

29034, 33444, 37854

2575 VPI EUDD4B78 2575 B985 11395, I58D5. 20215, 24B25, murine norovirus GV/CRI0/2005/0SA

29035, 33445, 37855

257B VPI AB28ID85 257B B98B 11396, 15806, 20216, 24B2B, norovirus Hu/GII.2/Zwolle25E/200l/NL

29036, 3344B, 3785B

2577 VPI ABBB28B8 2577 B987 11397, 15807, 20217, 24B27, norovirus Hu/GII.2/0H0802D/2D08/JP

29037.33447, 37857

2578 VPI ABBB28BI 2578 B988 11398, 15808, 20218, 24B28, norovirus Hu/GII.2/OCD8l54/2008/JP

29038, 33448, 37858

2579 VPI LCI4579I 2579 B989 11399, 15809, 20219, 24629, norovirus Hu/GII.2/Saitama4 20l2_JP

2B039, 33449.37859

258D VPI LCI4579D 258D B99D 11400, 15810, 20220, 24630, norovirus Hu/GII.2/Fukui2_20l2JP

29040, 33450, 37860

2581 VPI LCI45793 2581 B9BI 11401, 15811. 20221. 24631, norovirus Hu/GII.Z/Dsakacity5_ZDI2_JP

29041, 33451, 378BI

2582 VPI LCI45792 2582 6992 11402, 15812, 2D222, 24632, norovirus Hu/GII.2/Saitama5_ZOI2_JP

29042, 33452, 378B2

2583 PI LCI45797 2583 B993 11403, 15813, 20223, 24633, norovirus Hu/GII.2/Ehime2_20l2_JP

29043, 33453, 37863

2584 VPI LCI45808 2584 B994 11404, 15814, 20224, 24634, norovirus Hu/GII.2/Ehime5_20l4_JP

29044.33454, 37864

2585 VPI LCI458DI 2585 B995 11405, 15815, 20225, 24B35, norovirus Hu/GII.2/Miyagi2_20l4_JP

29045, 33455, 37865

258B VPI ABBB2884 258B B99B 11406, 15816, 20226, 24B3B, norovirus Hu/GII,2/OH09032/2009/JP

29046, 3345B, 3786B

2587 VPI LCI458D2 2587 B997 11407, 15817, 20227, 24B37, norovirus Hu/GII,2/0saka4_20l4_JP

29047, 33457, 378B7

2588 VPI ABBB2807 2588 B998 11408, 15818, 20228, 24638, norovirus Hu/GII.2/0HI0D2l/2DID/JP

29048, 33458, 37868

2589 VPI ABBB2899 2589 6999 11409, 15819, 20229, 24639, norovirus Hu/GII,2/OHI0025/20IO/JP

29049, 33459, 378B9 2530 VPI ABBB2894 2530 7DDD 11410, 15820, 20230, 24B40, norovirus Hu/GII.2/DHIDDI3/ZOIO/JP

2905D, 334B0, 37870

2591 VPI LCI458D3 2531 7001 II4II, 15821, 20231, 24B4I, norovirus Hu/GII.Z/Dsaka5_ZDI4_JP

23051, 334BI, 37871

25B2 VPI ABBB288B 2592 7002 11412, 15822, 2B232, 24B42, norovirus Hu/GII.2/OHI0006/20IO/JP

23052, 33462, 37872

2593 VPI ABBB287B 2533 7003 11413, 15823, 20233, 24B43, norovirus Hu/GII.2/OCIOOI2-2/20IO/JP

29053, 334B3, 37873

2534 VPI KU55584I 2534 7D04 11414, 15824. 20234, 24644, norovirus Hu/GII.I7/C0HK-NS-864/HKG/20l6

23054.334B4.37874

2595 VPI GQ85B4B8 2535 7005 11415. 15825, 20235, 24B45, norovirus Hu/GII.4/Beijing/55l85/2008/CHN

29055, 334B5, 37875

2536 VPI ABB84B8I 2536 7006 11416, 15826. 20236. 24646. norovirus Hu/GII/27-3/Tokyo/l376/JPN

2305B, 3346B, 37876

2537 PI AB8B9388 2537 7007 11417. 15827, 20237, 24647, norovirus Hu/GII.I3/03N3B45/2D09/NP

2S057.33467.37877

2598 VPI AB8ID0II 2538 7008 11418. 15828. 20238, 24B48, norovirus Hu/GII.I3/ION4489/20IO/NP

28058, 33468, 37878

2533 VPI AB8D3334 2533 7003 11413, 15823, 20239, 24B49, norovirus Hu/GII.I3/03N3758/2003/NP

29059, 33469, 37873

2BDD VPI KX7B7083 26B0 7010 11420, 15830, 20240, 24B50, norovirus Hu/GII.4/Melbourne6623/20l6/A0S

2B060.33470, 37880

2BBI VPI LN8545B5 2B0I 7011 11421, 15831. 20241, 24B5I, norovirus Gll/Hu/NL/20I2/Gll.4/Groningen

29061, 33471, 37881

2B02 VPI KX354D7I 2B02 7012 11422, 15832, 20242, 24652, norovirus GII.4

23062, 33472.37882

2B03 VPI ABS3368B 2B03 7013 11423, 15833, 20243, 24653, norovirus Hu/GII.4/Shimane5/20IO/JP

2B063, 33473, 37883

2BD4 VPI GQ845337 2B04 7014 11424, 15834, 20244, 24G54, norovirus Hu/GII.4/NSW53BS/2B08/A0

230B4, 33474, 37884

2BD5 VPI JXI55747 2BD5 7015 11425, 15835, 20245, 24B55, norovirus Hu/GII.4/Xi'an/CB/2BI0/CHN

29BB5, 33475, 37885

2BBB VPI JXI55737 26D6 7016 11426, I583B, 2024B, 24B56, norovirus Hu/GII.4/Xi'an/PI3/2DI0/CHN

29066, 33476.37886 2BD7 VPI KX354055 2607 7017 11427, 15837, 20247, 24657, norovirus GII.4

29067, 33477, 37887

2GD8 VPI X353957 2608 7018 11428, 15838, 20248, 24658, norovirus GII.4

29068, 33478, 37888

2600 VPI KF509947 2609 7019 11429, 15839, 20249, 24659, norovirus Hu/GII.4/Alb _B rtaEI337/20ll/CA

29069, 33479, 37889

2610 VPI AB50432G 2610 7020 11430, 15840. 20250, 24660, norovirus Hu/Gll.4/Hiroshima/I29/2007/JPN

29070, 33480, 37890

2611 VP! KX354056 2611 7021 11431. 15841, 20251, 24661, norovirus GII.4

29071, 33481, 37891

2612 VPI AB54I255 2612 7022 11432, 15842, 20252, 24662, norovirus Hu/GIM/Hiroshima3/2007/JP

29072, 33482, 37892

2613 VPI KP784696 2613 7023 11433, 15843, 20253, 24663, norovirus

29073, 33483, 37893 GII/Hu/ZAF/20l2/GII.P4_GII.4/CapeTown/977

2

2614 VPI KX354042 2EI4 7024 11434, 15844, 20254, 24664, norovirus GII.4

29074, 33484.37894

2615 VPI KX354007 2615 7025 11435, 15845, 20255, 24665, norovirus GII.4

29075.33485, 37895

2616 VPI KT78Q333 2616 7026 11436, 15846, 20256, 24666, norovirus Hu/GII.4/CUH -NS-663/HKG/20l5

29076, 33486, 37896

2617 VPI X354043 2617 7027 11437, 15847, 20257, 24667, norovirus GII.4

29077, 33487, 37897

2618 VPI KX354008 2618 7028 11438, 15848, 20258, 24668, norovirus GII.4

29078, 33488, 37898

2619 VPI 9042I7 2619 7029 11439, 15849, 20259, 24669, norovirus Gil

29079, 33489, 37899

2620 VPI KJ6854I2 2620 7030 11440, 15850, 20260, 24670, norovirus Hu/Gll/BGIC0405/20I2/BGD

29080, 33490, 37900

2621 VPI KF0DB240 2621 7031 11441, 15851, 20261, 24671, norovirus Hu/Gll.4/ variant Sydney 2012/FRA

29081, 33491, 37901

2622 VPI KX354IZ5 2622 7032 11442, 15852, 20262, 24672, norovirus GII.4

29082, 33492, 37902

2623 VP! KX354094 2623 7033 11443, 15853, 20263, 24673, norovirus GII.4

29083, 33493, 37903 2624 VPI KX354058 2624 7034 11444, 15854, 20264, 24B74, norovirus GII.4

29084.33494, 37904

2625 VPI KX354057 2B25 7035 11445, 15855, 20265, 24675, narovirus GII.4

29085, 33495, 37905

2626 VP! KX354034 2B26 7036 11446, 15856, 20266, 24676. norovirus GII.4

29086, 33496, 37906

2627 VPI KX354027 2627 7037 11447, 15857, 20267, 24677, norovirus GII.4

29087, 33497, 37907

2628 VPI KX354D25 2628 7038 11448, 15858, 20268, 24B78, narovirus GII.4

2BD88, 33498, 37908

2B2B VPI J68540G 2623 7039 11449, 15859, 20269. 24679, norovirus Hu/Gll/BGICD39I/20I2/BG0

29089, 33499.37909

2630 VPI KF00824I 2630 7040 11450, 15860, 20270, 24680. norovirus Hu/GII.4/variant Sydney 2012/FRA

29090.335D0, 37910

2B3I VPI A6504327 2631 7041 11451, 15861, 20271, 24681. norovirus Hu/Gll.4/Hiroshim_/I34/2B07/JPN

29091.33501, 37911

2632 VPI KY424329 2B32 7042 11452, I58B2, 20272, 24682, norovirus GII.4

29092, 33502, 37912

2633 VPI KT78038B 2B33 7043 11453, 15863, 20273, 24683, norovirus Hu/GII.4/CUH -NS-65l/HKG/20l5

29093, 33503, 37913

2B34 VP! KX354I34 2634 7044 11454, 15864, 20274, 24B84, norovirus GII.4

29094, 33504.37914

2B35 VPI KX354I26 2635 7045 11455, 15865, 20275, 24685, norovirus GII.4

29095, 33505.37915

2B3B VPI KRB04237 263B 7046 11456, I586B, 2027B, 24686, norovirus Gil

29096, 33506, 37916

2B37 VPI KP24I9II 2B37 7047 11457, I58B7, 20277, 24687, norovirus GII.4

29097, 33507, 37917

2638 VPI JBS54I1 2638 7048 11458, 15868. 20278, 24688, nomvirus Hu/Gll/BGIC0398/20I2/BGD

29098, 33508, 37918

2B38 VPI KF008242 2639 7049 11459, I58B9, 20279. 24689, norovirus Hu/GII.4/ ariant Sydney 2012/FRA

29099, 33509, 37919

2640 VPI KF060II2 2640 7050 11460, 15870, 20280, 4690, norovirus Hu/GII.4/NSW8632/20l2/A0

29100, 33510, 37920 264! VPI JXI269I2 2641 7D5I 11461, 15871, 20281, 24691, norovirus Hu/Bli.4/0hia/7l/20l2/USA

29101, 33511, 37921

2642 VPI X354I43 2642 7D52 11462, 15872, 20282, 24692, norovirus GII.4

29102, 33512, 37922

2643 PI K0985IG4 2643 7D53 11463, 15873, 20283, 24693, narovirus GII.4

29103, 33513, 37923

2644 VPI KXB50760 2644 7054 11464, 15874, 20284, 24694, norovirus Hu/GII.4/CUH -NS-IOB4/H G/2DIB

29104, 33514, 37024

2645 VPI KJ685402 2645 7055 11465, 15875, 20285, 24695, norovirus Hu/Gll/BGIC0434/20I2/BGD

29105, 33515, 37925

2646 VPI FB60I4D 2646 7056 11466, 15876, 20286, 24696, norovirus Hu/GII.4/NLV-IZ-B72/2DI2/NZ

29ID6, 33516, 37926

2647 VPI KX354I32 2647 7057 11467, 15877, 20287, 24697, norovirus GII.4

29107, 33517, 37927

2648 VPI KX354006 2648 7058 11468, 15878, 20288, 24698, norovirus GII.4

29108, 33518, 37928

2649 VPI KX354I45 2649 7059 11469, 15879, 20289, 24699, norovirus GII.4

29109, 33519.37929

265D VPI KX354I40 2650 7060 11470, I588D, 20290, 24700, norovirus GII.4

29110, 33520, 37930

2651 VPI KX354II9 2651 7061 11471, 15881, 20291, 24701, norovirus GII.4

29111, 33521, 37931

2652 VPI KX3540I8 2652 7062 11472, 15882, 20292, 247D2, norovirus GII.4

29112, 33522, 37932

2653 VPI A6972499 2653 7063 11473, 15883, 20293, 24703, norovirus Hu/GII.4/GII4-H 0l/20ll/JP

29113, 33523, 37933

2654 VPI FQ60I42 2654 7064 11474, 15884, 2D294, 24704, noravirus Hu/GII.4/NLV-l2-723/20l2/NZ

29114. 33524, 37934

2655 VPI KFD6DI38 2655 7065 11475, 15885. 20295. 24705, norovirus Hu/GII.4/NLV-l2-65/20l2/NZ

29115, 33525, 37935

2656 VPI KP784697 2656 7066 11476, 15886, 20296, 24706, norovirus

29116, 33526, 37936 GII/Hu/ZAF/20l2/GII.P4_GII.4/CapeTown/IOIO

5

2657 VPI FD6DIII 2657 7067 11477, 15887, 20297. 24707, norovirus Hu/GII.4/NSW8G2G/20l2/AU

29117, 33527, 37937 2G58 VPI KF0B0089 2B58 7068 11478. 15888. 20298, 24708. riDrovirus Hu/GII.4/NSWB84S/2DI2/AU

29118, 33528.37938

2659 VPI KP096333 2659 70B9 11479, 15889, 20299. 24709. norovirus Hu/GII/H G/2DI4/BII.4/CUHK-NS- 29119, 33529, 37939 383

2GGD VPI KF060I53 266D 7070 11480, 15890, 20300, 24710, norovirus Hu/GII.4/NLV-l2-934/ZDI2/NZ

29120, 3353D, 37940

2GGI VPI KF0G0I25 2BBI 7071 11481, 15891, 20301, 24711, norovirus Hu/GII.4/NLV-l2-ID34/20l2/NZ

29121, 33531, 37941

2GG2 VPI X354I35 2B62 7072 11482, 15892, 203D2, 24712, norovirus GII.4

29122, 33532, 37942

2663 VPI KX354045 2663 7073 11483, 15893, 20303, 24713, norovirus GII.4

29123, 33533, 37943

2G64 VPI LCI53I2I 2664 7074 11484, 15894, 20304, 24714, norovirus GII/Hu/JP/20IG/GII.PI6_GII.4_

29124, 33534, 37944 SydnBy20l2/0HI6002

2665 VPI KFG68568 2665 7075 11485, 15895, 20305, 24715, norovirus Hu/Gll.4/PA48/20I2/ITA

29125, 33535.37945

2666 VPI KFB68567 266B 7076 11486, I589B, 20306, 24716, norovirus Hu/GII.4/PA3B3/20ll/ITA

29126, 33536, 37946

2667 VPI KR9042I0 2B67 7077 11487, 15897, 20307, 24717, norovirus Gil

29127, 33537, 37947

2668 VPI JX4599D7 2668 7078 11488, 15898, 20308, 24718. norovirus

29128.33538, 37948 Hu/GII.4/Woonona/NSW33D9/2012/A0

266B VPI KFDBDDB2 2669 7D79 11489, 15899, 20309, 24719, norovirus Hu/GII,4/NSW558V/20l2/AU

29129, 33539, 37949

2670 VPI KF060080 2670 7080 11490, 15900, 20310, 24720, norovirus Hu/Gll,4/NSWB28G/20I2/A0

29130, 33540, 37950

2B7I VPI KF37873I 2671 7081 11491, 15901, 20311, 24721, narovirus PAI3/20I3/ITA

29131, 33541, 37951

2G72 VPI AB33373I 2672 7082 11492, 15902, 20312, 24722, norovirus Hu/GII.4/Hokkaidol/2009/JP

29132, 33542, 37952

2673 VPI AB933749 2G73 7083 11493, 15903, 20313, 24723, norovirus Hu/GII.4/Sakai5/2009/JP

29133, 33543, 37953

2674 VPI KC5I7370 2674 7084 11494, 15904, 20314, 24724, norovirus Hu/GII- 29134, 33544, 37954 4/Taoyuan/CGMH60/20l2/TW 2675 VPI EF547396 2675 7085 11495, 15905. 20315, 24725, narovirus Hu/Akabanfi/99ll3D/l99g/JP/2258

29135, 33545, 37955

2676 VPI JN609D47 2676 7086 11496, 15906, 20316, 24726, noravirus Hu/Gl/E8/0G/I97G

29136, 33546, 37956

2677 VPI T78I4II 2677 7087 11497, 15907, 20317, 24727, noravirus GI.3

29137, 33547, 37957

2678 VPI UD4469 2678 7088 11498, 15908, 20318, 24728, desert shield virus

29138, 33548, 37958

2678 VPI J699049 2679 7089 11499, 15909, 20319, 24729, noravirus Hu/Gl.3/C9/GF/I978

29139, 33549, 37959

2680 VPI G0856473 268D 7000 11500. 15910, 20320, 24730, narovirus Hu/GII.4/8eijing/55042/2007/CHN

29140, 33550, 37960

2681 VPI JN699D5D 2681 7091 11501, 15311, 20321, 24731, noravirus Hu/Gl.3/B8/CF/I977

29141, 33551, 37961

2682 VPI GQ856472 2682 7092 11502, 15912, 20322, 24732, narovirus Hu/GlI.4/Beijing/54BBD/2007/CHN

29142, 33552, 37962

2683 VPI GQ85647I 2683 7093 11503, 15913, 20323, 24733, narovirus Hu/GII.4/Beijing/54ll4/2007/CHN

29143, 33553, 37963

2684 VPI JQeil594 2684 7094 11504, 15914, 20324, 24734, narovirus Hu/Gl/I0360/20I0/VNM

29144, 33554, 37964

2685 VPI GU296356 2685 7095 11505. 15915, 20325, 24735, noravirus Hu/GI/Lilla Edet/p2/SWE/2008

29145, 33555, 37965

2686 VPI M46I693 2686 7096 11506, 15916, 20326, 24736, noravirus II-FJ-3/20I1/GII.P7/GII.6

20146, 33556, 37966

2687 VPI LCI45789 2687 7097 11507, 15917. 20327, 24737, noravirus Hu/GII.2/Fukuil_20l2_JP

29147, 33557, 37967

2688 VPI KXI7I4I7 2688 7098 11508, 15918, 20328, 24738, narovirus D 11.1 ^* 7

29148, 33558, 37968

2688 VPI KXI7I4I2 2689 7099 11509. 15919, 20329, 24739, narovirus 011.17

29149, 33559, 37969

268D VPI U557839 2690 7100 11510, 15920, 20330. 24740. noravirus Hu/GII.I7/2238/GD-JM/20l3-D8-30

29150, 33560, 37970

2691 VPI P9D2564 2691 7101 II5II, 15921, 20331, 24741, noravirus Hu/GII.I7/H G/2DI4/CUHK-NS-27G

29151, 33561, 37971 2GBZ VPI KU587625 2632 7102 11512, 15322, 20332, 24742, norovirus GII.I7

23152, 335G2, 37372

2633 VPI XI7I4I3 2633 7103 11513, 15323, 20333, 24743, norovirus 011.17

23153, 335B3, 37373

2B34 VPI KP902565 2634 7104 11514, 15324. 20334, 24744, norovirus Hu/GII.I7/HKG/20l4/CUHK-NS-3G0

23154, 335B4, 37974

2G95 VPI KXI7I4I6 2635 7105 11515, 15925, 20335, 24745. norovirus GII.I7

29155, 33565, 37975

2636 PI K056I250 2636 7I0B 11516, I592B. 20336, 2474B, norovirus 011.17

23156, 33566, 37976

2607 VPI K056I25I 2637 7107 11517, 15827, 20337, 24747, norovirus GII.I7

29157. 33567, 37977

2638 VPI AB8ID0I4 2638 7108 11518, 15928, 20338, 24748. norovirus Hu/GII.I3/ION4598/20IO/NP

23158. 33568, 37378

2639 PI AB809385 2639 7103 11513. 15323, 20333, 24743. norovirus Hu/GII.I3/09N3564/2009/NP

23159, 33563, 37979

2700 VPI AB8I0003 2700 7110 11520, 15330, 20340, 24750, norovirus Hu/GII.I3/ION4254/20IO/NP

29160, 33570, 37980

2701 VPI AB809S75 27DI 7111 11521, 15931, 20341, 24751, norovirus Hu/GII.I3/09N3l20/2009/NP

29161, 33571, 37981

2702 PI JX40I280 2702 7112 11522, 15932. 2D342, 24752, norovirus Hu/Gll/KL45/MY/I978

29162, 33572, 37982

2703 VPI C962462 2703 7113 11523, 15933, 20343, 24753, norovirus Gil

29163, 33573, 37983

2704 VPI KX353374 2704 7114 11524. 15934, 20344, 24754. norovirus GII.4

29164, 33574, 37984

2705 VPI F060I22 2705 7115 11525, 15935, 20345, 24755, norovirus Hu/GII.4/NLV-IO-603/20IO/NZ

29165. 33575. 37985

2706 PI K 904234 2706 7116 11526. 15936, 20346, 24756, norovirus Gil

29I6B, 33576, 37986

2707 PI K 13I7B9 2707 7117 11527, 15937, 20347, 24757. norovirus GII/HU/IN/2009/GII.PE_GII.4_

23167, 33577, 37387 0saka2007/Pune-092434

2708 VPI KRI3I764 2708 7118 11528, 15938, 20348, 24758, norovirus GII/Hu/IN/2007/GII.Pe_GII.4_

29IB8, 33578, 37988 0saka2007/PunB-07l3603 270B VPI GU3BD3DI 27BB 7113 11523, 15333, 20343. 24753, norovirus Hu/GII.4/Chungnam(l2- 23IB0, 3357B, 37983 I07)/2008/ or

2710 VPI EUD78408 2710 7120 11530, 15940, 20350, 247B0, noravirus Hu/Lonacnning/200I/USA

29170, 33580, 37BB0

2711 VPI AB333B7G 2711 7121 1(531. 15941, 20351, 247BI. norovirus Hu/GII.4/Niigata2/20IO/JP

23171, 33581, 37991

2712 VPI KX354Q82 2712 7122 11532, 15942, 20352, 247B2, norovirus GII.4

29172, 33582, 37992

2713 VPI J4D707G 2713 7123 11533, 15943, 20353, 247B3, norovirus Hu/GII.4/HSBB/2DDI/USA

23173, 33583, 37393

2714 VPI JX453G3B 2714 7124 11534, 15944, 20354, 247B4, norovirus Hu/GII.4/SG40B7-OI/2009/SG

29174, 33584, 37994

2715 VPI JX445IBI 2715 7125 11535, 15945, 20355, 247B5, norovirus Hu/GII.4/AlbertaEI2IO/Z008/CA

29175, 33585, 37995

27IB VPI EU87G888 27IB 7I2G 11536. I594B, 2B35B, 247BB, norovirus Hu/GGII.4/Cairo8/20Q7/EGY

23I7B, 3358B, 3793B

2717 VPI EU833584 2717 7127 11537, 15347, 20357, 247B7, norovirus Hu/GII/Beijing/221/2005/CHN

23177, 33587, 37397

2718 VPI KX3540B0 2718 7128 11538. 15348. 20358, 247B8. norovirus GII.4

23178, 33588, 37998

27IB VPI KF0E0I24 2713 7123 11539, 15949. 20359, 47B9. norovirus Hu/GII.4/NLV-IO-B40/ZDIO/NZ

29179, 33589, 37339

272D VPI JX433B2B 2720 7130 11540, 15950, 203B0, 2477B, norovirus Hu/GII/Seoull400/K0R/2QI0

29180, 33590, 38000

2721 VPI JX4338I5 2721 7131 11541, 15951, 203BI, 24771, norovirus HU/GII/SEOUII055/K0R/20I0

29181, 33591, 38001

2722 VPI KC57G3I2 2722 7132 11542, 15952, 203B2, 24772, norovirus Hu/GII.4/NIHIC4.l/20ll/0SA

29182, 33592, 38002

2723 VPI G0845368 2723 7133 11543, 15953, 203B3, 24773, norovirus

2BI83. 33533. 38D03 Hu/GII.4/Sutherland/NSW505G/2D07/AUS

2724 VPI AB54I243 2724 7134 11544, 15954, 203B4, 24774, norovirus Hu/GII-4/Fukui5/20D7/JP

2BI84. 33594, 38004

2725 VPI EUB784I2 2725 7135 11545, 15955, 203B5, 24775, norovirus Hu/FL04/2004/0SA

29185, 33595, 38005 272G VPI AB445395 272B 7I3B II54B. I595B, 203BB, 2477B, norovirus Hu/GII.4/Apeldoorn3l7/2007/NL

29I8B, 33596, 38006

2727 VPI AB933G55 2727 7I37 II547, I5957, 20367, 24777, norovirus Hu/GII.4/ShimaneZ 2DD9/JP

29I87, 33597, 38007

2728 VPI M245072 2728 7I38 II548, I5958, 203B8, 24778, nomvirus 08-W- 29I88.33598, 38008 l/2008/GII.4/Apeldoorn/2007

2729 VPI AB54I282 2729 7I39 II549. I5959, 20369. 24779, norovirus Hu/Gtl-4/Miyagi2/ZD07/JP

29I89, 33599, 38009

2730 VPI AB54I202 2730 7I40 II550, I59GD, 2037D, 24780, nomvirus Hu/GII-4/Aichil/2008/JP

29190.33600, 38010

273I VPI FJ5I4242 273I 7I4I 11551. 15961, 20371, 24781, norovirus Hu/GII-4/C0K-3/2008/K

29191, 33601, 38011

2732 VPI X35397B 2732 7I42 11552, 15962, 20372, 24782, nomvirus GII.4

29192, 33602, 38012

2733 VPI KX353952 2733 7I43 11553, 15963, 20373, 24783, nomvirus GII.4

29193, 33603, 38013

2734 VPI K I3I77I 2734 7I44 11554, 15964, 20374, 24784, norovirus GII/HU/IN/2008/GII.PE_GII.4_

29194, 33604, 38014 0saka2007/Pune-084Q93

2735 VPI AB933729 2735 7I45 11555, 15965, 20375, 24785, norovirus Hu/GII.4/Fukui5/2009/JP

29195, 33605, 38015

273G VPI AB933B4B 273G 7I4B 11556, 159BB, 20376, 2478B, norovirus Hu/GII.4/Shimanel/Z0Q9/JP

29196.33606, 38016

2737 VPI JXI55742 2737 7I47 11557, 15967, 20377, 24787, norovirus Hu/GII.4/Xi'an/PI43/2DI0/CHN

29197, 33607, 38017

2738 VPI J40QBI4 2738 7I48 11558, 15968, 20378, 24788, nomvirus Hu/GII-4/CGMHIG/2007/TW

29198, 33608, 38018

2733 VPI J400B0I 2739 7I49 11559, 15969, 20379. 24789. norovirus Hu/GII-4/CG H03/2006/TW

29199, 33B09, 38019

2740 VPI J06I3538 2740 7I50 11560, 15970, 20380, 24790, norovirus Hu/GII.4/NSW452P/20D9/A0

29200, 33610, 38020

274I VPI HM802543 274I 7I5I 11561, 15971, 20381, 24791, norovirus Hu/GII.4/Hong

29201, 33611, 38021 ong/CU050IOB/2005/CHN

2742 VPI AB54I337 2742 7I52 11562, 15972, 20382. 24792, norovirus Hu/GII-4/Saga5/Z007/JP

29202, 33612, 38022 2743 VPI AB54I252 2743 7153 11563, 15973, 2D383, 24793, norovirus Hu/GII-4/Hiroshimal/200B/JP

29203. 33613, 38023

2744 VPI GU27D580 2744 7154 11564, 15974, 20384, 24794, narovirus Hu/GII.4/New

29204, 33614, 38024 0rl _E ansl500/2008/USA

2745 VPI EU87B882 2745 7155 11565, 15975, 20385, 24705, narovirus Hu/GGII.4/Caira2/200G/EGY

29Z05, 33615, 38025

2746 VPI AB933B49 274B 7I5B 11566, 15976, 20386, 24796, narovirus Hu/GII.4/Hiros imacity3/2009/JP

29206. 33BIB, 3802B

2747 VPI JX4398IB 2747 7157 11567, 15977, 20387, 24797, narovirus HU/GII/SEOUII072/K0R/20I0

29207, 33617. 38027

2748 VPI JXI55739 2748 7158 11568, 15978, 2D388, 24798, noravirus Hu/GII.4/Xi'an/P4B/20IO/CHN

29208, 33618. 38028

2743 VPI HQ45G338 2749 7159 11569, 15979, 20389, 24799, narovirus Hu/GII.4/08-N-l(2008a)/2008/TW

29209, 33619, 38029

275D VPI AB54I359 2750 7IBD 11570, 15980, 20390, 24800, narovirus Hu/GII-4/Tayama4/2007/JP

29210, 33620, 38030

2751 VPI AB54I28Q 2751 7IBI 11571. 15981, 20391, 24801, narovirus Hu/GII-4/Kumamoto4/2007/JP

29211, 33B21, 38031

2752 VPI AB54I244 2752 7IB2 11572, 15982, 20392, 24802, narovirus Hu/GII-4/Fukuil/2D08/JP

29212, 33622, 38032

2753 VPI AB54I203 2753 7IB3 11573, 15983, 20393, 24803, narovirus Hu/GII-4/Aichi2/2007/JP

29213. 33623, 38033

2754 VPI GQ850882 2754 7IB4 11574, 15984. 20394, 24804, narovirus Hu/GII,4/Rivieral590/2008/US

29214, 33624, 38034

2755 VPI KRI3I772 2755 7IB5 11575. 15985, 20395, 24805, norovirus GII/Hu/IN/2008/GII.P4_GII.4_

29215, 33625, 38035 Apeldoorn2007/Pune-0866l9

275B VPI R9Q42I5 275B 7IBB 11576, 15986, 20396, 24806, nornvirus Gil

29216, 33626, 38036

2757 VPI AB9337I5 2757 7IB7 11577. 15987, 20397, 24807, narovirus Hu/GII.4/lwate4/2DII/JP

29217, 33G27. 38037

2758 VPI AB933B95 2758 7IB8 11578, 15988. 20398. 24808, narovirus Hu/GH.4/SakailO/20ll/JP

29218, 33628, 38038

2753 VPI AB933B8I 2759 7IB9 11579. 15989, 20399, 24809, narovirus Hu/GII.4/Fukui4/20IO/JP

29219, 33629, 38039 27BD VPI AB933675 27B0 7170 11580, 15990. 20400, 24810, norovirus Hu/GII.4/HokkaidD4/2DI0/JP

29220, 33B30, 38D40

27BI VPI ABB33B52 27BI 7171 11581, 15991, 20401, 24811. norovirus Hu/GII.4/lwate2/2D09/JP

29221, 33B31, 38041

27B2 VPI F4297B2 27B2 7172 11582, 15992, 20402, 24812, norovirus Hu/Gll.4/NIHICI7.7/20I2/0SA

29222, 33B32, 38042

27B3 VPI JXB44D27 27B3 7173 11583, 15993, 20403, 24813, norovirus Hu/GII.4/N3/Z0D8/HuZhou

29223, 33633, 38043

27B4 PI JN4DQBI7 27B4 7174 11584, 15994, 20404, 24814, norovirus Hu/Gil-4/CG HI9/2DDB/TW

29224, 33B34.38044

27B5 VPI JQ6I35I9 27B5 7175 11585, 15995, 20405, 24815, norovirus Hu/GII.4/NSW39l2/2008/AU

29225, 33635, 38045

27BB VPI HQ45634I 27BB 7176 11586, 15986. 20406, 24816, norovirus Hu/GII.4/08-W-l(2008b)/20D8/TW

29226, 33636, 38046

27B7 PI HMB02540 27B7 7177 11587, 15997, 20407, 24817. norovirus Hu/GII.4/Hong

29227, 33637, 38047 ong/CU050l4l/2005/CHN

27B8 VPI AB54I257 27B8 7178 11588, 15998, 20408, 24818. norovirus Hu/GII-4/Hiroshima4/2007/JP

29228, 33B38, 38048

27BB VPI AB54I242 2769 7179 11589, 15999, 20409. 24819, norovirus Hu/GII-4/Ehime4/2008/JP

29229.33639, 38049

277D VPI AB54I225 2770 7180 11590, I6Q00. 20410, 24820, norovirus Hu/GII-4/Aomori4/2008/JP

29230, 33640, 38050

2771 VPI AB54II90 2771 7181 11591, 16001, 20411, 24821, norovirus Hu/GII-4/2007a_0RF2-3/JP

29231, 33641.38051

2772 VPI AB402092 2772 7182 11502, 16002, 20412. 24822, norovirus

29232, 33B42, 38052 Hu/Gll.4/Stockholm/I9865/2008/SE

2773 VPI EU9IB95B 2773 7183 11593, 16003. 2D4I3, 24823, norovirus Hu/Monastir 8655/2007/TUN

29233, 33643, 38053

2774 VPI EFI2B9B2 2774 7184 11594, 16004, 20414, 24824, norovirus Hu/GII.4/0enHaag54/20DB/NL

29234, 33644, 38054

2775 VPI ABBB3B87 2775 7185 11595, 16005, 20415, 24825. norovirus Hu/GII.4/Wakayama/TIG9/20IO/JP

29235, 33645, 38055

277B VPI AB933759 277B 7I8G 11596. 16006, 204IB, 24826, norovirus Hu/GII.4/Nagano2B/20ll/JP

29236, 33646, 38056 2777 PI AB333755 2777 7187 11597, IB007, 20417. 24827, norovirus Hu/GII.4/Saga2/2009/JP

29237, 33B47, 38057

2778 VPI AB333B77 2778 7188 11598, IB008, 20418, 24828, norovirus Hu/GII.4/Niigata3/20IO/JP

29238, 33B48, 38058

2773 VPI AB933650 2779 7183 11599, IB0D9, 20413, 24823, norovirus Hu/GII.4/Hiroshimacity4/20Q3/JP

23239, 33B49, 38059

278D VPI M24507I 2780 7130 11600. 16010, 20420, 24830, norovirus 08-F- 29240, 33B50, 38060 2/2008/GII.4/DenHaag/2006b

2781 VPI KF7I2437 2781 7131 11601, 16011, 20421, 24831, norovirus Hu/Gll.4/NIHIC27.2/20I2/USA

29241, 33B51, 38061

2782 VPI KCSB0823 2782 7132 11602, 16012, 20422, 24832, norovirus Hu/GII.42006b/092835/2008/0SA

29242, 33B52, 38062

2783 VPI JX433843 2783 7133 11603. 16013, 20423, 24833, norovirus Hu/GII/Seoull43l/KOR/20IO

29243, 33G53, 38063

2784 VPI JX43384I 2784 7134 11604, 16014, 20424, 24834, norovirus Hu/GII/Seoull32l/K0R/20l0

29244, 33654, 38064

2785 VPI JX433830 2785 7135 11605, 16015, 20425, 24835, norovirus Hu/GII/Seoull049/K0R/20l0

29245.33655, 380B5

2788 VPI JX43S828 278B 7136 II60B, 16016, 20426, 24836, norovirus Hu/GII/Seoul!456/K0R/20ll

29246, 33656, 38066

2787 VPI JX445I53 2787 7137 11607, 16017, 20427, 24837, norovirus Hu/GII.4/AlbertaEII42/2006/CA

29247, 33657, 38067

2788 PI JXI55754 2788 7138 11608, IB0I8. 20428, 24838, norovirus Hu/GII.4/Xi'an/C45/20IO/CHN

29248, 33658, 38068

2783 VPI JN4DDB08 2789 7133 11609, 16019, 20429, 24839, norovirus Hu/GII-4/CG HI0/2006/TW

29249, 33659, 38069

2730 VPI EFI87437 2730 7200 11610, 16020, 20430, 24840, norovirus

29250.33660.38D70 Hu/GII.4/Kenepuru/NZ327/20D6/NZL

2731 VPI ABBB8028 2731 7201 II6II, 16021. 20431, 24841, norovirus sBwage/GII/lnfluent/Nov200G/JPN

29251.33B61.38071

2732 VPI HM802542 2792 7202 11612. 16022. 20432. 24842, norovirus Hu/GII.4/Hong

29252.33B62, 38072 Kong/C0050l40/2005/CHN

2733 VPI HQB035I3 2793 7203 11613, 16023. 20433, 24843, norovirus Hu/GII.4/JB-l5/K0R/2O08

23253, 33663, 38073 2734 VPI AB54I322 2794 7204 IIBI4, IB024, 20434, 24844, norovirus Hu/GII-4/Osaka2/2008/JP

29254, 33BB4, 38074

2795 PI AB54I32I 2795 7205 IIBI5, IB025, 20435, 24845, norovirus Hu/GII-4/0saka2/2007/JP

29255, 33BB5, 38075

279B VPI AB54I253 279B 720B IIBIB, IB02B, 2043B, 2484B, norovirus Hu/GII-4/Hiroshima2/2007/JP

2925B, 33BBB, 3807B

2797 VPt AB54I250 2797 7207 IIBI7, IB027, 2B437, 24847, norovirus Hu/GII-4/Fukui5/2008/JP

29257, 33BB7, 38077

2798 VPI AB54I2II 2798 7208 IIBI8, IB028, 20438, 24848, norovirus Hu/GII-4/Akital/2007/JP

29258, 33BB8, 38078

2790 VPI GQ248797 2799 7209 IIBI9, 16029. 20439, 24849, norovirus Hu/GGII.4/Dijon/E3642/2008/FRA

29259, 33BB9, 38079

280D VPI GQ24B794 2800 7210 IIB20, IG030, 20440, 24850, norovirus Hu/GGII.4/Dijon/E3436/2008/FRA

2926D, 33B70, 38080

2801 PI E087B884 2801 7211 11621, 16031, 20441, 24851, norovirus Hu/GGII.4/Cairo4/200B/EGY

29261, 33671, 38081

2802 VPI FJ4III70 2802 7212 11622, 16032, 20442, 24852, norovirus Hu/GII.4/Henry/2000/0SA

29262, 33672, 38082

2803 VPI E0839589 2803 7213 11623, 16033, 2D443, 24853, norovirus Hu/GII/BBijing/34/20D6/CHN

29263.33B73, 38083

28D4 VPI KX3539BI 2804 7214 11624. IB034, 20444, 24854, norovirus GII.4

292B4, 33B74, 38084

2805 VPI AB933757 2805 7215 11625, IB035, 20445, 24855, norovirus Hu/GII.4/Saga4/2009/JP

29265, 33B75.38085

2806 VPI KM245074 280B 72IG 11626, 16036, 20446, 24856, norovirus 09-N- 2926B, 3367B, 38086 l/2Q09/GII.4/DenHaag/2006b

2807 VPI E092I3B8 2807 7217 11627, 16037, 20447, 24857, norovirus GII/Hu/IN/2007/GII.P4_GII.4_

29267, 33B77, 38087 Hunter2004/Pune-PC3l

2808 VPI EUB2I338 2808 7218 IIB28, IB038. 20448. 24858, norovirus GII/Hu/IN/2005/GII.P4_GII,4_

29268, 33678, 38088 Hunter2004/Pune-PC09

2809 VPI LC005708 2809 7219 11629, 16039, 20449, 24859, norovirus GII/Hu/JP/2008/GII.4/y08-207-2

29269, 33679, 38089

2810 VPI LCD05704 2810 7220 11630, IB040, 20450, 24860, norovirus GII/Hu/JP/2007/GII.4/y0G-V82-2

29270, 33B80, 38090 2811 PI F429777 2811 7221 IIG3I, IBD4I, 2B45I, 248BI, norovirus Hu/Gll.4/NIHIC27.I/20I2/0SA

29271, 33B81, 38D9I

2812 VPI JX43884D 2812 7222 IIB32, IBB42, 2D452, 248B2, noravirus Hu/Gil/Seoutl253/ D /20ID

29272, 33682.38092

2813 VPI JXG44D2G 2813 7223 11633. IBD43, 20453, 248B3, norovirus Hu/GII.4/N2/200B/HuZhou

29273, 33B83, 38093

2814 VPI JX4599DG 2814 7224 11634, IB044, 20454, 24864, noravirus

29274, 33684, 38094 Hu/GII.4/Miranda/NSWB5DK/201l/AU

2815 VPI JX45B597 2815 7225 IIG35. 16045, 20455, 248B5, norovirus Hu/GII.4/SG4033-DI/2D05/SG

29275, 33685, 38095

2816 VPI HQ45G334 28IB 722G 11636, 16046, 20456, 24866, norovirus Hu/GII.4/08-D-l(2008a)/2008/TW

2927B, 33B86, 38096

2817 VPI HM8D2553 2817 7227 11637, 16047, 20457, 248B7, norovirus Hu/GII.4/Hong

29277, 33B87, 38097 ong/C005IOI3/2005/CHN

2818 VPI HQQG8055 2818 7228 11638, 16048, 20458, 24868, norovirus Hu/GII.4/8483/2008/ZAP

29278, 33688, 38098

2818 VPI AB54I3G0 2819 7229 11639, 16049, 20459, 24869, norovirus Hu/GII-4/Toyama4/2008/JP

29279, 33689, 38099

282D VPI AB54I2G2 282B 723D 11640, 16050, 20460, 24870, norovirus Hu/GII-4/Hokkaido2/2007/JP

29280, 33690, 38100

2821 VPI AB54I23I 2821 7231 11641, 16051, 20461, 24871, norovirus Hu/GII-4/Chiba2/2008/JP

29281, 33691, 38101

2822 VPI BD24B792 2822 7232 11642. 16052, 204B2, 24872, norovirus Hu/GGII.4/Qijon/E3l65/2008/FRA

29282, 33692, 38102

2823 VPI AB5D4329 2823 7233 11643. 16053, 20463, 24873, norovirus Hu/Gll.4/Hiroshima/I5l/2008/JPN

29283, 33693, 38103

2824 VPI AB5Q43DB 2824 7234 11644, 16054, 20464, 24874, norovirus Hu/Gll.4/Hiroshima/I9/200I/JPN

29284, 33B94, 38104

2825 PI GQ3Q3445 2825 7235 11645, 16055, 20465, 24875, norovirus Hu/ annliEiml3l/2DD9/DE

29285, 33695, 38105

282B VPI EU839588 2828 723G 11646, I605B, 20466, 24876, norovirus Hu/GII/Beijing/07/2006/CHN

29286.33696, 38106

2827 VPI DQ3G4459 2827 7237 11647, 16057. 20467, 24877, norovirus Gil

29287, 33697, 38107 2828 VPI YG28449 2828 7238 IIB48, IB058, 204B8, 24878, noravirus GII.4

29288, 33698, 38108

2829 VPI KX371B08 2829 7239 11649, IB059, 20469, 24879, norovirus GII.4

29289, 33699, 38109

2830 VPI KX354D89 2830 7240 11650, IBOBO, 20470, 24880, norovirus GII.4

29290, 33700, 38110

2831 VPI KX35400I 2831 7241 IIB5I, 16061, 20471, 24881, norovirus GII.4

29291, 33701, 38111

2832 VPI KX35397I 2832 7242 11652, 16062, 20472. 24882, noravirus GII.4

29292, 33702, 38112

2833 VPI RI3I7G6 2833 7243 11653. IB0B3, 20473. 24883, norovirus GII/Hu/IN/2008/GII.Pe_GII.4_

29293, 33703, 38113 0saka2007/PunE-084D97

2834 VPI ABBG3B85 2834 7244 11654. 16064, 20474, 24884, norovirus Hu/GII.4/Wakayama/TI62/20IO/JP

29294.33704, 38114

2835 VPI AB93374B 2835 7245 11655. IB065, 20475. 24885, norovirus Hu/GII.4/0sakal/2009/JP

29295, 33705, 38115

283B VPI AB93370I 283B 724B 11656. 16066, 20476, 24886, norovirus Hu/GII.4/Akita3/20ll/JP

29296, 33706, 38116

2837 VPI AB933B8B 2837 7247 11657. 16067, 20477. 24887, norovirus Hu/GII.4/Ehime5/2BI0/JP

29297, 33707, 38117

2838 VPI AB933B80 2838 7248 11658, 16068. 20478, 24888, norovirus Hu/GII.4/Fukui3/20IO/JP

29298, 33708, 38118

2839 PI AB933B72 2839 7249 11659, 16069, 20479. 24889, norovirus Hu/GII.4/Hirushima4/20IO/JP

29299, 33709, 38119

2840 VPI AB933BB4 2840 7250 11660. 16070, 20480, 24890, noravirus Hu/GII.4/Naganal/20IO/JP

29300, 33710, 38120

2841 VPI AB933BB2 2841 7251 IIBBI, 16071, 20481, 24891, norovirus Hu/GII.4/Chiba3/20IO/JP

29301, 33711, 38121

2842 VPI AB933B5B 2842 7252 11662, 16072, 20482, 24892, noravirus Hu/GII.4/Miyazakil/2009/JP

29302, 33712.38122

2843 VPI EU92I34B 2843 7253 11663, 16073. 20483, 24893, noravirus GII/Hu/IN/200B/GII.P4_GII.4_

20303, 33713, 38123 YersekB200Ga/Pun _E -PCII

2844 VPI KC962453 2844 7254 11664. 16074, 20484, 24894, norovirus Gil

29304.33714, 38124 2845 VPI F7I250I 2845 7255 11665. IB075, 2D485, 24895. norovirus Hu/Gll.4/NIHICI7.G/20I2/USA

293B5, 33715, 38125

284B VPI JX459903 284B 725B 11666, IBD7B, 2D48B, 2489B, nnrovirus

293DB, 337IB, 38I2B Hu/GII.4/Jannali/NSW774M/20ll/AU

2847 VPI JX459B29 2847 7257 IIGB7. IB077, 20487, 24897, norovirus Hu/GII.4/SG4069-OI/2008/SG

29307, 33717, 38127

2848 VPI JX445IB5 2848 7258 11668, IB078, 20488, 24898, norovirus Hu/GII.4/AlbertaEIII9/ZOIO/CA

29308, 33718, 38128

2849 VPI HMB35I5G 2849 725B 11669. 16079, 20489, 24899, norovirus Hu/GII.4/Seoul/0945/2009/K0R

29309, 337IB, 38129

2850 VPI JQB22I97 285B 72BD 11670. IBD80, 20490. 249D0. norovirus Hu/GII-4/CBN02/2007/KR

29310, 33720, 38130

2851 VPI JQ6I3520 2851 72BI IIG7I. 16081, 20491, 24901. norovirus Hu/GII.4/NSW04IG/2008/AU

29311, 33721.38131

2852 VPI HQ45B32B 2852 72B2 11672. 16082, 20492, 24902, norovirus Hu/GII.4/04R-2/2004/TW

29312, 33722, 38132

2853 VPI A854I353 2853 72B3 11673, IB083, 20493, 24903, norovirus Hu/GII-4/Shimane5/2008/JP

29313.33723, 38133

2854 VPI A854I348 2854 72B4 11674, 16084. 20494, 24904, norovirus Hu/GII-4/Shimane2/2008/JP

29314, 33724.38134

2855 VPI AB54I339 2855 72B5 11675, I6D85, 20495. 24905, norovirus Hu/GII-4/Sakail/2007/JP

29315, 33725. 38135

285B VPI AB54I3D3 285B 72BB 11676, 16086, 2049B, 2490B, norovirus Hu/GII-4/Nagano2/2007/JP

293IB, 33726, 38136

2857 VPI GD24B799 2857 72B7 11677. IB087, 20497, 24907, norovirus Hu/GGII.4/0ijon/E3808/2009/FRA

29317, 33727, 38137

2858 VPI EU87B88B 2858 72B8 11678, IB088. 20498. 24908, norovirus Hu/GGII.4/Cairo6/2006/EGY

29318, 33728.38138

2859 VPI AB385B30 2859 7269 11679, 16089, 20499, 24909, norovirus Hu/GII.4/RotterdamP3D0/2D06/NL

29319, 33729, 38139

28BD VPI UI82483 28BB 7270 11680, 16090, 20500, 24910. norovirus GII.4

29320, 33730, 38140

28BI VPI ABBB53B4 28BI 7271 11681, 16091, 20501, 24911, norovirus Hu/GII,4/0saka/NV22ID/2007/JP

29321, 33731, 38141 2862 VP) AB663G86 28G2 7272 11682. IB092. 20502, 24912, narovirus Hu/GII.4/Wakayama/TI64/20IO/JP

29322, 33732, 38142

28B3 VPI AB933702 28B3 7273 11683. 16033, 20503, 24913, narovirus Hu/GII.4/0saka3/20ll/JP

29323, 33733.38143

28G4 VP! AB933G85 28B4 7274 11684, 16094, 20504, 24914, noravirus Hu/GII.4/Ehime3/20IO/JP

29324, 33734, 38144

28G5 VPI ABB33G45 28B5 7275 11685, 16095, 20505, 24915, narovirus Hu/GII.4/Toyama4/2009/JP

29325.33735, 38145

28G6 VPI LC00570G 28BB 727B IIG86. I609G, 20506, 24916, norovirus GII/Hu/JP/2008/GII.4/y07-VI79-l

29326, 33736, 38I4B

28G7 VPI KMI985B2 28B7 7277 11687, 16097, 20507, 24917, narovirus Hu/GII/C2H-55/20ll/VNM

29327, 33737.38147

28G8 VPI KC4D93II 28B8 7278 11688. 16098, 20508, 24918, narovirus Hu/GII/30199/2009/VNM

29328, 33738, 38148

28G9 VPI C4Q92B3 28B9 7279 11689, 16099, 20509, 24919, narovirus Hu/Gll/20I73/200B/VNM

29329, 33739, 38149

2870 VPI JX4599Q0 2870 7280 11690, 16100, 20510, 24920, norovirus

29330, 33740, 38150 Hu/GII.4/Randwick/NSW882J/20ll/A0

2871 VPI JX459BI7 2871 7281 IIB9I, 16101. 20511. 24921, norovirus Hu/GII.4/SG4047-0l/2007/SG

29331, 33741, 38151

2872 VPI GQ84536G 2872 7282 11692, I6ID2, 20512, 24922, norovirus

29332, 33742.38152 Hu/GII.4/WBstmead/NSW3639/2008/AUS

2873 VPI GQ845345 2873 7283 11693, 16103, 20513. 24923, norovirus Hu/GII.4/NSW80BJ/2008/A0

29333, 33743, 38153

2874 VPI GQ84534I 2874 7284 11694, 16104, 20514. 24924, norovirus Hu/GII.4/NSW587V/2007/A0

29334, 33744, 38154

2875 VPI HQ005292 2875 7285 11695. 16105. 20515, 24925, norovirus Hu/ll.4/222l223/HK/2009

29335, 33745, 38155

287G VPI HQ45G32I 287B 728G 11696. 16106. 20516, 24926, norovirus Hu/GII.4/05R-2/2005/TW

29336, 3374B, 38156

2877 PI AB54I32G 2877 7287 11697, 16107, 20517, 24927, norovirus Hu/GII-4/0saka4/2008/JP

29337, 33747, 38157

2878 VPI AB54I25I 2878 7288 11698. 16108. 20518, 24928, narovirus Hu/GII-4/Hiroshimal/2007/JP

29338, 33748, 38158 2870 VPI AB54I24I 2879 7280 IIBOO, 16109. 20519, 24929, narovirus Hu/GII-4/Ehim _E 4/2007/JP

29339, 33749, 38159

2880 VPI AB54I2IB 2880 720D 11700, IBIIO, 20520, 24930, norovirus Hu/GII-4/Akita4/2D08/JP

29340, 33750, 38IB0

2881 VPI EU87B885 2881 7291 11701, IBIII, 20521, 24931, noravirus Hu/GGII.4/Cairo5/20D6/EGY

29341, 33751, 38IBI

2882 VPI AB447435 2882 7202 11702, IBII2, 20522, 24932, noravirus Hu/GII-4/Aomori5/200B/JP

29342, 33752, 38IB2

2883 VPI KX354073 2883 7203 11703, IBII3, 20523, 24933, narovirus GII.4

29343, 33753, 38163

2884 VPI KX35398I 2884 7204 11704, 16114, 20524, 24934, narovirus GII.4

29344, 33754, 38164

2885 VPI UI82479 2885 7205 11705, 16115, 20525, 24935, noravirus GII.4

29345, 33755, 38165

2886 VPI UI82478 288B 720B 11706, 16116, 20526, 24936, noravirus GII.4

29346, 33756, 38166

2887 VPI AB97250I 2887 7207 11707, 16117, 20527, 24937, narovirus Hu/GII.4/6ll4-H D3/2DII/JP

29347, 33757, 38167

2888 VPI 9D42I4 2888 7208 11708, 16118, 20528, 24938, narovirus Gil

29348, 33758, 38168

2889 VPI AB933758 2880 7290 11709, 16119, 20529, 24939, narovirus Hu/GII.4/Chiba6/20ll/JP

29349, 33759, 38169

289D VPI AB933B98 2890 7300 11710. 16120, 20530. 24940, noravirus Hu/GII.4/Hirashimacity2/20ll/ JP

29350, 33760, 38170

2891 VPI KJ678I4I 2801 7301 II7II, 16121, 20531, 24941, narovirus Hu/GII.4/Beijing/PKUPH-02- 29351, 33761, 38171 08/inpatient/20l3/CHN

2892 VPI EU92I347 2802 7302 11712. 16122. 20532, 24942. noravirus GII/Hu/IN/2006/GII.P4_GII.4_

29352, 33762, 38172 YErsBkB2006a/Pune-PCI8

2893 PI JX459B28 2803 7303 11713. 16123. 20533, 24943, noravirus Hu/GII.4/SG4D63-ID/20D7/SG

29353, 33763, 38173

2894 VPI JQBI35B4 2804 7304 11714, 16124, 20534, 24944, noravirus Hu/GII.4/NSW944J/2DID/AU

29354, 33764, 38174

2895 VPI GQ845332 2805 73D5 11715. 16125, 20535, 24945, narovirus Hu/GII.4/NSW6l8P/20O8/A0

29355, 33765, 38175 2896 VPI GQ85646I 2896 7306 II7IB, I6I26, 20536. 24946. norovirus Hu/GII.4/B _E ijing/546G7/2007/CHN

29356, 33766, 38I76

2897 VPI AB54I245 2897 7307 H7I7. I6I27, 20537, 24947, norovirus Hu/GII-4/Fukui2/2007/JP

29357, 33767, 38I77

2898 VPI AB54I229 2898 7308 II7I8. I6I28, 20538, 24948, narovirus Hu/Gll-4/Chibai/2DD8/JP

29358, 33768.38I78

2899 VPI AB54I226 2899 7309 II7I9, I6I29, 20539, 24949, nDrovirus Hu/GII-4/Aomori5/2DD7/JP

29359, 33769, 38I79

29DD VPI DQ0788I4 2900 73I0 II720, I6I30, 20540, 24950, noravirus Hu/GII.4/Hunter504Q/04Q/AU

29360, 33770, 38I80

29DI VPI EU0784IG 290I 73II II72I, I6I3I, 2054I. 2495I, noravirus Hu/Billings/2006/USA

2936!, 33771, 38I8!

2902 VPI E0839590 2902 73I2 II722, I6I32, 20542, 24952, norovirus Hu/GII/Beijing/116/2007/CHN

29362, 33772, 38182

2903 VPI AB294783 2903 73I3 11723, 16133, 20543, 24953. noravirus Hu/GII-4/ atari/04l008/2004/JP

29363.33773, 38183

2904 VPI AB30334I 2904 73I4 11724, 16134, 20544, 24954, noravirus Hu/GGII.4/Nijmegen083/2004/NL

29364, 33774, 38184

2905 VPI EFI2696I 2905 73I5 11725. 16135, 20545, 24955. norovirus Hu/GII.4/Dangen46/200G/NL

29365, 33775, 38185

2906 VPI LCI53749 2906 73I6 11726, 16136. 20546, 24956, naravirus Hu/GII.4/ yo-TCN/20IO/JP

29366, 33776, 38186

2907 VPI X37I6I0 2907 73I7 11727, 16137, 20547, 24957, noravirus GII.4

29367, 33777, 38187

2908 VPI KX354031 2908 73I8 11728, 16138, 20548, 24958, noravirus GII.4

29368, 33778, 38188

2909 VPI X353990 2909 73I9 11729, 16139, 20549, 24959, noravirus GII.4

29369, 33779, 38189

29I0 VPI X353972 29I0 7320 11730, 16140. 20550. 24960. norovirus GII.4

29370, 33780.38190

29I1 VPI KX353968 29II 732I 11731. 16141, 20551, 24961, noravirus GII.4

29371, 33781, 38191

29I2 VPI KX353967 29I2 7322 11732, 16142, 20552, 24962, norovirus GII.4

29372, 33782, 38192 2313 VPI KX353966 2913 7323 11733, 16143. 2D553, 24963, norovirus GII.4

29373, 33783, 38193

2914 VPI ABBB3B84 2914 7324 11734, 16144, 2D554, 24964, norovirus Hu/GII.4/Wakayama/TI58/20IO/JP

29374. 33784, 38194

2915 VPI KR9042D9 2915 7325 11735, 16145, 2D555, 24965, norovirus Gil

29375, 33785, 38195

29IG VPI AB9337IB 29IB 732B 11736, I6I4G, 2D55B. 24966, norovirus Hu/GII.4/lwate5/20ll/JP

29376, 33786, 38196

2917 VPI AB933BBB 2917 7327 11737, IBI47, 20557, 24967, norovirus Hu/GII.4/0saka2/2DI0/JP

29377. 33787. 38197

2918 VPI EU92I349 2918 7328 11738, 16148, 20558, 24968, norovirus GII/Hu/IN/200G/GII,P4_GII.4_

29378, 33788, 38198 YersekB200Ga/PunE-PC20

2919 VPI EU92I348 2919 7329 11739, 16149, 20559. 24969, norovirus GII/Hu/IN/2006/GII.P4_GII.4_

29379, 33789. 38199 Y _E rsBkB2006a/Pune-PCI9

292D VPI EU92I345 292G 733D 11740, 16150, 20560. 24970, norovirus GII/Hu/IN/200B/GII.P4_GII.4_

29380, 33790, 38200 YErsBke2006a/Pune-PCI6

2921 VPI PG98924 2921 7331 11741. IBI5I, 20561, 24971, norovirus GII.4

29381, 33791, 38201

2922 VPI LC0057D7 2922 7332 11742, 16152. 20562. 24972, norovirus GII/Hu/JP/2008/GII,4/y07-V203-l

29382, 33792, 38202

2923 VPI KJ54I743 2923 7333 11743, 16153, 205B3, 24973, norovirus Hu/GII.4/SG0-H042l/ DR/20ll

29383. 33793, 38203

2924 VPI FI77443 2924 7334 11744, 16154, 205G4. 24974, norovirus Hu/GII,4/3585778B/AUS/2012

29384, 33794, 38204

2925 VPI JX439842 2925 7335 11745, 16155, 205B5, 24975, norovirus HU/GII/SEOUII35I/K0R/20I0

29385, 33795, 38205

2926 VPI HF052I35 292B 733B 11746, 16156, 2056B, 2497G, norovirus Hu/GII.4/C00007952/20ll/UK

29386, 3379B, 38206

2927 VPI JX459598 2927 7337 11747, 16157, 205B7, 24977, norovirus Hu/GII.4/SG4039-02/2005/SG

29387, 33797, 38207

2928 VPI JX445IB2 2928 7338 11748, 16158. 20568, 24978, norovirus Hu/GII.4/AlbertaEI425/2008/CA

29388, 33798, 38208

2929 VPI JX445I54 2929 7339 11749. 16159, 20569, 24979, norovirus Hu/GII.4/Alb _E rtaEII90/200G/CA

29389, 33799, 38209 2930 VPI JXI55752 2330 7340 11750, 16160. 20570, 24980, norovirus Hu/GII.4/Xi'an/C3l/2DI0/CHN

29390, 33800, 38210

2931 VPI HM74897I 2931 7341 11751. 16161, 20571, 24981, norovirus

23391, 33801, 38211 Hu/GII.4/8eecroft/NSW305P/2009/AUS

2932 VPI GD8453B7 2332 7342 11752, 16162. 20572, 24382, norovirus

23332, 33802, 38212 Hu/GII.4/0range/NSW00IP/2008/AU

2933 VPI G085B455 2333 7343 11753. 16163. 20573, 24383, norovirus Hu/GII.4/Beijing/55058/2007/CHN

29333, 33803, 38213

2934 VPI G0856447 2334 7344 11754, 16164. 20574, 24984, norovirus Hu/GII.4/8eijing/540SI/2007/CHN

29334, 33804, 38214

2935 VPI AB54I3I8 2335 7345 11755. 16165. 20575, 24985, norovirus Hu/GII-4/Niigata5/2008/JP

29395.338D5, 38215

293G VPI AB54I3B7 233B 734B 11756. 16166. 20576, 24986, norovirus Hu/GII-4/Nagano4/2008/JP

29396, 3380B, 38216

2937 VPI AB54I254 2337 7347 11757, 16167. 20577, 24987, norovirus Hu/GII-4/Hiroshima2/2008/JP

23337.33807.38217

2938 VPI AB54I243 2338 7348 11758, 16168. 20578, 24388, norovirus Hu/GII-4/Ehime5/2008/JP

23338, 33808.38218

2939 VPI AB54I232 2339 7343 11753, 16169. 20579. 24989, norovirus Hu/GII-4/Chiba4/2007/JP

29399, 33809, 38219

294D VPI GQ246800 2940 735B 11760, 16170. 20580, 24990, norovirus Hu/GGII.4/0ijon/E388D/2003/FRA

29400, 33810, 38220

2941 PI GU39D90D 2941 7351 11761, IBI7I, 2D58I, 24331. norovirus Hu/GII.4/Chungnam(ll- 23401, 33811, 38221 34)/20B8/ or

2942 VPI AB504328 2942 7352 11762, 16172, 20582, 24992. norovirus Hu/Gll.4/Hiroshima/I39/2007/JPN

29402, 33812, 38222

2943 VPI AB447434 2943 7353 11763, 16173, 2B583, 24993, norovirus Hu/GII-4/Aomori4/2006/JP

29403, 33813, 38223

2944 VPI EU83353I 2944 7354 11764. 16174. 20584, 24994. norovirus Hu/GII/BBijing/125/2007/CHN

29404.33814.38224

2945 VPI AB2BI542 2945 7355 11765, 16175, 20585, 24995, norovirus Hu/Gff.4/KobeD34/2DDB/JP

29405, 33815, 38225

294B VPI X354I23 294B 735B 11766, 16176, 20586, 2499B, norovirus GII.4

29406, 33816.38226 2947 VPI KX354B5D 2947 7357 11767. 16177. 2B587, 24997, narovirus GII.4

294B7, 33817, 38227

2948 VPI AB9337I7 2948 7358 11768. 16178. 2B588. 24998. noravirus Hu/BII.4/Toyama5/20ll/ JP

294B8, 33818, 38228

2949 VPI AB933707 2949 7359 11769, 16179, 2B589, 24999, narovirus Hu/GII.4/Saga2/20ll/JP

29409, 33819, 38229

295D VPI AB9337B5 295B 73BD 11770, 16180, 20590, 25000, noravirus Hu/GII.4/Ehime2/20ll/JP

29410, 33820, 38230

2951 VPI AB933704 2951 73BI 11771, 16181, 20591, 25001, narovirus Hu/GII.4/Ehimel/20ll/JP

29411, 33821, 38231

2952 VPI AB933B99 2952 73B2 11772, 16182, 20592, 25002, narovirus Hu/GII.4/Akita2/20ll/JP

29412, 33822, 38232

2953 VPI AB933B79 2953 73B3 11773, 16183, 20593, 25003, noravirus Hu/GII,4/Fukui2/20IO/JP

29413, 33823, 38233

2954 VPI AB933BBI 2954 73B4 11774, 16184, Z0594, 25004, noravirus Hu/GII.4/Chibal/20IO/JP

29414, 33824, 38234

2955 VPI KTI52I48 2955 73B5 11775, 16185, 20595, 25005, narovirus Hu/GII.P4_6ll.4/MinBrva/2006/USA

29415, 33825, 38235

295B VPI EU92I393 295B 73BB 11776, 16186. 2059B, 25006, narovirus GII/Hu/IN/2DD7/GII.P4_GII.4_

29416, 33826, 38236 DenHaag2006b/Pune-PC56

2957 VPI KM39BBBI 2957 73B7 11777, 16187. 20597, 25007, norovirus GII/Hu/H G/ZDI4/GII.4/CUH -NS- 29417, 33827, 38237 339

2958 VPI KMI98485 2958 73B8 11778, 16188, 20598, 25008, norovirus Hu/GII/IOI48/2009/VNM

29418, 33828, 38238

2959 VPI KF3DB2I4 2959 73B9 11779. 16189, 20593, 25009, noravirus Hu/Gll.4/Jingzhou/20I34Q3/CHN

29419, 33829, 38239

29BD VPI JX43983I 29GB 737D 11780, 16190, 20B00, 25010, norovirus HU/GII/SEOUIII2I/K0 /20I0

29420, 33830, 38240

29BI VPI KC4D928I 29BI 7371 11781. 16191, 20601, 25011, narovirus Hu/GII/20229/2009/VNM

29421, 33831, 38241

29B2 VPI JX459B39 29B2 7372 11782, 16192. 20602. 25012. narovirus Hu/GII.4/SG4028-07/2009/SG

29422, 33832, 38242

29B3 VPI JX459BD9 29B3 7373 11783, 16183. 20603, 25013, narovirus Hu/Gll.4/SG40I5-I0/2006/SG

29423, 33833, 38243 2BB4 VPI JN400599 29B4 7374 11784. 16194, 20B04, 25DI4, noravirus Hu/BII-4/CBMH0l/2DDB/TW

29424.33834, 38244

2BB5 VPI J0BI3539 29B5 7375 11785, 16195. 20B05, 25015, nomvirus Hu/Gll.4/NSW447T/2009/A0

29425.33835, 38245

29GB VPI HQ45G329 29BB 737B II78B, IGI96. 20BDB, 25016, noravirus Hu/GII.4/07-B-l/2006/TW

2942B, 3383B, 3824G

29B7 VPI HM80253B 23B7 7377 11787, 16197, 20B07, 25017, norovirus Hu/GII.4/Hong

29427, 33837, 38247 Kong/C0060039/2006/CHN

29B8 VPI HM802532 2968 7378 11788, 16198, 20608, 25018, noravirus Hu/GII.4/Hang

29428, 33838, 38248 ong/CUD60030/2006/CHN

29B9 VPI AB54I34I 29B9 7379 11789, 16199, 2D6B9, 25019, narovirus Hu/GII-4/Sakai2/2007/JP

29429, 33839, 38249

2970 VPI AB54I2G4 2970 7380 11790, IB200, 2DBI0, 25020, narovirus Hu/GII-4/Hokkaido3/2008/JP

29430, 33840, 38250

2971 VPI AB54I236 2971 7381 11701. 16201. 20611, 25021, norovirus Hu/GII-4/Ehimel/2007/JP

29431, 33841, 38251

2972 VPI AB54I208 2972 7382 11792, IB202, 20612. 25022. narovirus Hu/GII-4/Aichi4/2008/JP

29432.33842.38252

2973 VPI EU87B890 2973 7383 11793. I62D3, 20613, 25023, norovirus Hu/GGII.4/Dijon-EID57/ZD02/FRA

29433, 33843, 38253

2974 VPI AB385638 2974 7384 11794, 16204, 20614, 25024, norovirus

29434, 33844, 38254 Hu/GII.4/RottBrdamP6D33/2006/NL

2975 VPI AB385B35 2975 7385 11795, 16205, 20615, 25025, narovirus

29435, 33845, 38255 Hu/GII.4/RotterdamP5D36/2005/NL

297B VPI EU3BBII3 2976 738B 11796, I62D6, 206IB, 25026, norovirus Hu/Duan/Beijing/2006/China

29436, 33846, 38256

2977 VPI KX3540B7 2977 7387 11797. 16207, 20617, 25027, noravirus GII.4

29437, 33847, 38257

2978 VPI AB933727 2978 7388 11798, 16208, 20618. 25028, norovirus Hu/GII.4/ChibalO/20ll/JP

29438, 33848, 38258

2979 VPI AB93372B 2979 7389 11799, 16209, 20619, 25029, norovirus Hu/GII.4/Ehime4/20ll/JP

29439, 33849, 38259

2980 VPI AB933720 2980 7390 11800, 16210, 20620, 25030, norovirus Hu/GII.4/Hiroshima2/2DII/JP

29440, 33850, 38260 2981 VPI AB933G9I 2381 7331 11801, IB2II, 20B2I, 25031. norovirus Hu/GII.4/Miyazaki5/2DID/JP

29441.33851, 38261

2982 VPI AB933B82 2982 7332 11802. 16212, 20622, 25032, norovirus Hu/GII.4/Nagano3/2010/JP

29442, 33852, 38262

2983 VPI KM2450BB 2983 7333 II8D3. 16213, 20B23, 25033. nnrovirus 06-AM- 29443, 33853, 382B3 ll/2006/GII.4/Yerseke/2006a

2984 VPI LCBD57I7 2984 7394 11804, 16214, 2BB24, 25034, norDvirus GII/Hu/JP/20l2/GII.4/yll-V683-2

23444, 33854, 382B4

2985 VPI LCGB57B5 2985 7395 11805, 16215, 20B25, 25D35, norovirus GII/Hu/JP/2007/GII.4/y0G-VII0-5

29445, 33855, 38265

2986 VPI KC894943 298B 739B 11806, 16216, 20626, 25036, nnrovirus Hu/GII.4/Guangzhou/GZ20IO- 2344B, 33856, 38266 L3I/CHN/20II

2987 VPI KF0BBG23 2987 7397 11807, 16217. 20B27. 25037, norovirus Hu/GII.4/NSW25BG/2DI2/AU

23447, 33857, 38267

2988 VPI KC40S3IB 2988 7398 11808, 16218, 20628. 25038, norovirus Hu/GII/30l2S/2009/VNM

29448, 33858, 38268

2989 VPI JX989B73 2989 7399 11803, 16213, 20623, 25039, norovirus Hu/GII.4/GZ20IO- 23449, 33859, 38269 L2B/Buangzhnu/CHN/20I0

299D VPI JX4599D2 2330 7400 11810, 16220, 20B30, 25040, norovirus

2345B, 338B0, 38270 Hu/GII.4/B _E rowra/NSW767L/20l2/AU

2991 VPI JX459B44 2331 74BI II8II, 16221. 20631. 25041, nnrovirus Hu/GII.4/SG404G-09/2009/SG

29451, 33861, 38271

2992 VPI JX453BID 2992 74B2 11812, IB222, 20B32. 25B42, norovirus Hu/GII.4/SG4030-l2/2006/SG

29452, 33862, 38272

2993 VPI JX459BBB 2933 7403 11813, 16223, 2D633, 25Q43, norovirus Hu/GII.4/SG406D-ID/2DDG/SG

23453, 33863, 38273

2994 VPI JX445I53 2334 7404 11814, IB224, 20634, 25044, norovirus Hu/GII.4/AlbertaEI009/2008/CA

23454, 338B4, 38274

2995 VPI JN400606 2335 7405 11815, 16225, 20635, 25D45. norovirus Hu/GII-4/CGMH08/2006/TW

23455, 33865, 38275

299B VPI JBBI35B2 2336 740B 11816, 16226. 20B3B, 25046, norovirus Hu/GII.4/NSWB270/2DID/AU

29456, 338B6, 38276

2997 VPI HQ45B343 2337 7407 11817. IB227, 20B37, 25047, norovirus Hu/GII,4/09-L-4(2009a)/2009/TW

23457, 33867, 38277 2BB8 VPI HQ45B342 2998 7408 11818. IB228, 2DB38, 25048. norovirus Hu/GII.4/08-AA(2008b)/2008/TW

23458, 338B8.38278

2993 VPI HQ45B34D 2999 7409 11819, IB229, 2BB39, 25049, norovirus Hu/GII.4/08-U-2(2008a)/2008/TW

23453, 338B9, 38273

3BB0 VPI HQ45B32B 3B0B 7410 11820, IB23B, 20B40, 25050, noravirus Hu/GII.4/DB-CJ-l 2DDB/TW

2B4B0, 33870, 38280

3001 PI HM802527 3001 7411 11821, 16231, 20B4I, 25051, norovirus Hu/GII.4/Hong

234BI, 33871, 38281 Kong/C00G00l2/2006/CHN

3002 VPI GQ856448 3002 7412 11822, IB232, 20B42, 25052, noravirus Hu/GII.4/Beijing/54ll6/2007/CHN

234B2, 33872, 38282

3003 VPI AB54I347 30B3 7413 11823, IB233, 20B43, 25053, noravirus Hu/GII-4/Shimane2/2Q07/JP

2S4B3, 33873, 38283

3004 VPI AB54I298 3004 7414 11824, IB234, 20B44, 25D54, norovirus Hu/GII-4/Miyazaki7/2008/JP

29464, 33874.38284

3005 VPI AB54I27B 3005 7415 11825, IB235. 2D645. 25055, noravirus Hu/GII-4/lwate2/2007/JP

29465, 33875, 38285

300B VPI AB54I2B3 300B 74IB 11826. IB23B, 2BB4B, 25056. norovirus Hu/GII-4/Hokkaido2/2008/JP

29466.3387B.38286

3007 VPI AB54I25B 3007 7417 11827, IB237, 20B47, 25057, noravirus Hu/GII-4/Hirashima3/2008/JP

2S467, 33877, 38287

3008 VPI AB54I240 3008 7418 11828, IB238. 2DB48, 25058, noravirus Hu/GII-4/Ehime3/2008/JP

23468. 33878, 38288

3003 VPI AB54I233 3009 7419 11823, IB239, 20649. 25059. noravirus Hu/GII-4/Chiba4/2008/JP

234B3, 33873, 38289

3DI0 VPI AB54I2I5 3010 7420 II83B. IB24B. 20B50, 2506B, norovirus Hu/GII-4/Akita3/2008/JP

29470, 3388B, 3829D

3GII VPI AB54I20I 3011 7421 11831, 16241, 2D65I. 250BI, norovirus Hu/GII-4/Aichil/20Q7/JP

29471. 33881.38291

3012 VPI FJ4III72 3012 7422 11832. 16242, 20652, 250B2, noravirus Hu/GII.4/RIS/2D0B/USA

29472, 33882, 38292

3BI3 VPI AB447449 3DI3 7423 11833, 16243. 2D653. 25063, narovirus Hu/GII-4/Sakai3/200B/JP

29473, 33883, 38293

3014 PI AB44743I 3014 7424 11834, 16244. 20654, 250B4, narovirus Hu/GII-4/Hokkaido5/20B6/JP

29474, 33884, 38294 3DI5 VPI EU0784I5 3DI5 7425 11835, IB245. 20B55, 250B5. norovims Hu/Ryndam/2005/0SA

29475, 33885.38295

3016 VPI AB385B43 30IB 742B 11836. IB24B, 20B56. 250B6, narovirus

29476.3388B, 3829B Hu/GII.4/RottBrdamP8D65/2006/NL

3017 VPI AB385B3B 3017 7427 11837, 16247. 20B57, 25067, noravirus Hu/GII.4/RotterdamP5D5l/2005/NL

29477.33887, 38297

3018 VPI AB385B29 3018 7428 11838, IB248, 20658. 250B8, norovirus

29478, 33888, 38298 Hu/GII.4/RDtterdamP2DI82/2005/NL

3019 VPI E083958B 3019 7429 11839, 16249, 20659. 25069, norovirus Hu/GII/Beijing/484/2005/CHN

29479, 33889.38299

3020 VPI E03I0927 302D 7430 11840, IB250, 20660, 25070, narovirus Hu/Houston/TCHI86/2002/US

29480, 33890, 38300

3021 VPI AB294787 3021 7431 11841, 16251, 20661, 25071, norovirus Hu/GII- 29481, 33891, 38301 4/lchikawa/05070l/2005/JP

3022 VPI AY587987 3022 7432 11842, 16252, 20BB2, 25072, norovirus Hu/NLV/0xford/B4S7/2002/UK

29482, 33892, 38302

3023 VPI AY5020I9 3023 7433 11843, 16253, 20663. 25D73, norovirus Gil

29483, 33893, 38303

3024 VPI LCI77B53 3024 7434 11844, IB254, 2DBB4, 25074, norovirus GII.4

29484, 33894, 38304

3025 VPI AB97248B 3025 7435 11845, 16255, 20665, 25075, norovirus Hu/GII.4/0sakaCity4/20l2/JP

29485, 33895, 38305

3026 VPI R904235 302B 743B 11846. 16256, 20666, 25076, norovirus Gil

29486, 33896, 38306

3027 VPI AB933753 3027 7437 11847. 16257, 20667, 25077, norovirus Hu/GII.4/Ehime4/2009/JP

29487, 33897, 38307

3028 VPI AB93372I 3028 7438 11848. IB258, 206B8, 25078, norovirus Hu/GII.4/Hiroshima4/20ll/JP

29488, 33898, 38308

3029 VPI AB93370B 3029 7439 11849. 16259. 206B9. 25079, norovirus Hu/GII.4/Sagal/20ll/JP

29489, 33899, 38309

3030 VPI AB933BB9 3030 7440 11850, 16260, 20G70, 25080. norovirus Hu/GII.4/Sakail/20IO/JP

29490, 33900.38310

3031 VPI EU92I350 3031 7441 11851, 16261, 20671, 25081, norovirus GII/Hu/IN/2006/GII.P4_GII.4_

29491, 33901.38311 Y _E rsEke200Ga/PunB-PC2l 3032 VPI LC0057I2 3032 7442 11852, IB2B2, 20B72, 25082, norovirus GII/Hu/JP/20IO/GII.4/y09-205-l

29492, 33902, 38312

3033 VPI LC0I8707 3033 7443 11853, IB2B3, 20B73, 25083, norovirus Hu/GII.4/AichiNishio7-l4/20l4

29493, 33903, 38313

3034 VPI K 982955 3034 7444 11854, IB2B4, 2DB74, 25084, norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 29494, 33904, 38314 369

3035 VPI KM38294e 3035 7445 11855, IB2B5, 20B75, 25085, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29495, 33905, 38315 3BI

3D3B VPI M40B485 303B 744B II85B, IB2BB, 2DB7B, 2508B, norovirus Hu/Gtl.4/ variant Sydney 2012/FRA

29496, 33906, 38316

3037 VPI I98574 3037 7447 11857, I62B7, 20B77, 25087, norovirus Hu/GII/IOI83/2009/VNM

29497, 33907, 38317

3038 PI MI985I7 3038 7448 11858, 162B8, 20678, 25088, norovirus Hu/GII/30399/2010/VNM

29498, 33908, 38318

3030 VPI JX439839 3039 7449 11859, 162B9, 20679, 25089, norovirus Hu/GII/Seoull2ll/KOR/20IO

29499, 33909, 38319

3040 VPI JX439837 3040 7450 11860, 16270, 20B80, 25090, norovirus HU/GII/SEOUII032/K0R/20I0

29500, 33910, 38320

3041 VPI KC63I8I5 3041 7451 11861, 16271. 20681, 25091. norovirus Hu/GII.4/ I002/20ll/OSA

29501, 33911, 38321

3042 VPI C4093I5 3042 7452 11862. 16272. 20682, 25092, norovirus Hu/GII/302ll/2009/VNM

29502, 33912, 38322

3043 VPI KC409289 3043 7453 11863, 16273, 20B83, 25D93, norovirus Hu/GII/20302/2009/VNM

29503, 33913, 38323

3044 VPI C4D9278 3044 7454 11864. IB274, 20684, 25094, norovirus Hu/GII/20208/2009/VNM

29504, 33914, 38324

3045 VPI KCI754Q2 3045 7455 11865, IB275, 20B85, 5095, norovirus Hu/Norwalk/20094/2009/VHM

29505, 33915, 38325

304B VPI JX459BIB 304B 745G 11866, 1627B, 20B8B, 25096, norovirus Hu/GII.4/SG404l-OI/2007/SG

29506, 33916, 38326

3047 VPI JX459599 3047 7457 11867, IB277, 20687, 25097, norovirus Hu/GII.4/SG409!-06/Z006/SG

29507, 33917, 38327

3048 VPI JN400B03 3048 7458 11868, 16278, 20688, 25D98, norovirus Hu/6ll-4/CGMH05/2006/TW

29508, 33918, 38328 3049 VPI JDGI3572 3D49 7459 11869. 16279. 20B89. 250SB, narovirus

29509, 33919, 38329 Hu/GII.4/StVincEnts/NSW2l7l/2DID/AU

3050 VPI JQGI3525 3050 74BD 11870, IB280, 20G90, 25100, noravirus Hu/GII.4/NSW8l90/2009/AU

29510, 33920, 38330

3051 VPI JQBI35I0 3051 74BI 11871. 16281, 20G9I, 25101, narovirus Hu/GII.4/NSWB33M/2D07/AU

29511, 33921, 38331

3052 VPI G0856450 3052 74B2 11872, 16282, 20692, 25102, norovirus Hu/GII.4/BEijing/54l35/2007/CHN

29512, 33922, 38332

3053 VPI AB54I29G 3053 74B3 11873, 16283, 2DG93, 25103, noravirus Hu/BII-4/ iyazaki5/2DD7/JP

29513, 33923, 38333

3054 VPI AB54I2I2 3054 74B4 11874, 16284, 20694, 25104, norovirus Hu/GII-4/Akital/2008/JP

29514, 33924, 38334

3055 VPI AB50432I 3055 74B5 11875, IB285, 20B95, 25105, noravirus Hu/GII.4/HiPDshima/92/20D6/JPN

29515, 33925, 38335

305B VPI AB294785 305B 74BB 11876. 16286, 2069B, 25106. noravirus Hu/GII-4/lnba/050590/2005/JP

295IB. 33926. 38336

3057 VPI AB234780 3057 74B7 11877, IB287, 20B97, 25107. noravirus Hu/GII-4/Chiba/040095/2003/JP

29517, 33927, 38337

3058 VPI AB3D3933 3058 74B8 11878, 16288, 2D698, 25108, narovirus Hu/GGII.4/Haarlem457/2003/NL

29518, 33928, 38338

3059 VPI AY587988 3059 74B9 11879, 16289, 20699, 25109, noravirus Hu/NLV/0xford/B4SI/2D02/0

29519, 33929, 38339

30GD VPI KX354103 30B0 7470 11880, IG290, 2070D, 25110, narovirus GII.4

29520, 33930, 38340

30BI VPI KX354048 30BI 7471 11881. 16291. 20701, 25111, narovirus GII.4

29521, 33931, 38341

30B2 VPI KX354047 30B2 7472 11882, 16292, 20702, 25112, noravirus GII.4

29522, 33932, 38342

30B3 VPI KU985IGI 3DB3 7473 11883, 16293, 20703. 25113, noravirus GII.4

29523, 33933, 38343

30G4 VPI AB9725I7 30B4 7474 11884, 16294, 20704, 25114, narovirus Hu/GII.4/Aichi3/2DI2/JP

29524, 33934, 38344

30G5 VPI AB972494 30B5 7475 11885, IG295, 20705, 25115, narovirus Hu/GII.4/Hirashima4/20l2/JP

29525, 33935, 38345 3066 VPI KU3IIIB3 30BB 747B II88B. IB29B, 2070B, 25IIG, norovirus Hu/GII.4/AlbertaSPI/20l3/CA

2952B, 33936.3834B

3067 VPI 90423B 30B7 7477 11887, IB297, 20707. 25117, narovirus Gil

29527, 33937.38347

3DB8 VPI KR904225 30B8 7478 11888. IB298, 20708, 25118, narovirus Gil

29528, 33938, 38348

30B9 VPI LC0057I0 30B9 7479 11889, 16299, 20709, 25119, norovirus GII/Hu/JP/2009/GII.4/y08-238-2

2952B, 33939, 38349

3D7D VPI LCDI8709 3070 7480 11890, 16300, 20710, 25120, norovirus Hu/Gll.4/Aichi352-I4/20I4

29530, 33940, 38350

307I VPI MI98587 307I 748I 11891, 16301, 20711. 25121, narovirus Hu/GII/20153/2009/VNM

29531, 33941, 3835!

3072 VPI KMI985BD 3072 7482 11892, IB302. 20712. 25122. norovirus Hu/GII/C2H-50/20ll/VNM

29532, 33942, 38352

3D73 VPI KMI9852I 3073 7483 11893, IB303, 20713, 25123, narovirus Hu/GII/10176/2009/VNM

29533, 33943, 38353

3D74 VPI KMI98490 3074 7484 11894. IB304, 20714, 25124, norovirus Hu/GII/10002/2009/VNM

29534, 33944, 38354

3D75 PI KC40924I 3075 7485 11895, 16305, 20715, 25125, norovirus Hu/GII/10405/2010/VNM

29535, 33945, 38355

307B VPI JX459B25 307B 748B 11896, 16306, 20716, 25126, narovirus Hu/GII.4/SG4086-09/2007/SG

29536, 33946, 38356

3B77 VPI JX459BI3 3077 7487 11897. 16307, 20717, 25127, narovirus Hu/Gll.4/SG4077-I2/200G/SG

29537, 33947, 38357

3D78 VPI JX459B00 3078 7488 11898, IB308, 20718, 25128, norovirus Hu/GII.4/SG4099-08/20D6/SG

29538, 33948, 38358

3D7B VPI JX459596 3079 7489 11899, IB309, 20719, 25129, norovirus Hu/GII.4/SG40l6-09/2004/SG

29539, 33949, 38359

3D8D VPI JXI55749 3080 7490 11900. 16310. 20720. 25130. narovirus Hu/GII.4/Xi'an/CI5/20IO/CHN

29540, 33950, 38360

3D8I VPI JQ6I35II 308I 7401 11901. IB3II. 20721, 25131, norovirus Hu/GII.4/WA223N/2007/AU

29541, 33951, 383BI

3082 VPI HM8Q2547 3082 7492 11902, 16312, 20722, 25132, norovirus Hu/GII.4/Hong

29542, 33952, 38362 Kong/C004l225/2004/CHN 3083 VPt HM802544 3083 7403 11903, 16313. 20723, 25133, norovirus Hu/GII.4/Hong

29543. 33953, 38363 ong/C005II4B/2005/CHN

3D84 VPI GD856456 3084 7494 11904, 16314, 20724, 25134, norovirus Hu/GII.4/Beijing/55DB5/20Q7/CHN

29544, 33954, 38364

3D85 VPI AB54I332 3085 7495 11905, 16315, 20725, 25135, norovirus Hu/GII-4/Saga2/2Q07/JP

29545, 33955, 38365

3086 VPI AB54I3I6 3086 7496 11906, 16316, 20726, 25I3B, norovirus Hu/GII-4/Niigata4/2008/JP

29546, 33956, 38366

3087 PI AB54I238 3087 7497 11907, 16317, 20727, 25137, norovirus Hu/Gil-4/Ehime2/2DD7/JP

29547, 33957, 38367

3088 VPI AB535750 3088 7498 11908, 16318, 20728, 25138, norovirus Hu/GII.4/0C090053/2D09/JPN

29548, 33958, 38368

3089 VPI FJ538900 3089 7499 11909, 16319, 20729, 25139, norovirus Hu/GII.4/Dijon/E872/2 D02/FRA

29549, 33959, 38369

3090 VPI EU87B889 3090 7500 11910. 16320, 20730, 25140, norovirus Hu/GGII.4/Cairo9/2007/EGY

29550, 33960, 38370

3091 VPI EU87B887 3091 7501 HEM. 16321, 20731, 25141, norovirus Hu/GGII.4/Cairo7/2007/EGY

29551. 33961, 38371

3092 VPI FJ4III7I 3092 7502 11912, 16322, 20732, 25142, norovirus Hu/GII.4/SSCS/2005/USA

29552, 339B2, 38372

3093 VPI AB4474B0 3093 7503 11913. 16323. 20733, 25143. norovirus Hu/GII-4/Kumamoto2/200B/JP

29553, 33963, 38373

3094 VPI AB447454 3094 7504 11914, IB324, 20734, 25144, norovirus Hu/GII-4/Ehime2/2006/JP

29554, 339B4, 38374

3095 VPI AB447443 3095 7505 11915, IB325, 20735, 25145, norovirus Hu/GII-4/Toyamal/200B/JP

29555, 33965, 38375

3096 VPI AB44743D 3096 7506 11016. IB32B, 2D736, 25146, norovirus Hu/GII-4/Hokkaido4/20D6/JP

29556, 33966, 3837B

3097 VPI E0078420 3097 7507 11917. IB327, 20737, 25147. norovirus Hu/MT0l/2006/USA

29557, 33967, 38377

3098 VPI AB385B37 3098 7508 11918. 16328, 20738, 25148, norovirus Hu/GII.4/RatterdamP6D0/200B/NL

29558, 33968, 38378

3099 VPI EF202568 3099 7509 11919. IB329, 20739, 25149, norovirus Hu/GII/Toronto/SK/2005/GAN

29559, 33969, 38379 3100 VP! AB29478I 3100 7510 11920, IB330, 20740, 25150, norovirus Hu/GII-4/Awa/040354/2004/JP

29560, 33970, 3838D

3101 VPI AB303940 3101 7511 11921, 16331. 20741, 25151, norovirus Hu/GGII.4/Tilburg059/ZDD4/NL

295BI, 33971, 38381

3ID2 VPI DQ4I5279 3102 7512 11922, 16332, 20742, 25152, norovirus Hu/GII/Carluw/2002/lre

29562, 33972, 38382

3ID3 VPI DD078794 3103 7513 11923, 16333, 20743, 25153, norovirus Hu/GII.4/Hunter 284E/040/AU

29563, 33973, 38383

3104 VPI KP78469I 3104 7514 11924, 16334, 20744. 25154, norovirus GII/Hu/ZAF/2009/GII.P4_GII,4/

295B4, 33974, 38384 JohannEsburg/4175

3105 VPI X9D7727 3105 7515 11925, 16335, 20745. 25155. norovirus

29565, 33975. 38385 Hu/USA/20l5/GII.PI6_GII.4_Sydney/CA3477

3I0G VPI X354049 3I0B 75IB 11926, 16336. 20746. 25156. norovirus GII.4

29566, 33976. 38386

3107 PI X354024 3107 7517 11927. 16337, 2D747, 25157, norovirus GII.4

29567, 33977, 38387

3108 VPI KX353955 3108 7518 11928, 16338, 20748, 25158, norovirus GII.4

295B8, 33978, 38388

3109 VPI AB9725I8 3109 7519 11929, 16339, 20749, 25159, norovirus Hu/GII.4/Aichi4/20l2/JP

29569.33979, 38389

3110 VPI AB933744 3110 7520 11930, 16340, 2075D, 25160, norovirus Hu/GII.4/Nagano5/2009/JP

29570, 33980, 38390

3111 VPI AB933B73 3111 7521 11931, 16341, 20751, 25161, norovirus Ho/GII.4/Miyazaki2/20IO/JP

29571, 33981, 38391

3112 VPI KM24507Q 3112 7522 11932, 16342. 20752, 25IB2, norovirus 07-B-l/2007/GII.4/0enHaag/2Q06b

29572, 33982, 38392

3113 VPI EU02I382 3113 7523 11933, 16343, 20753, 25163, norovirus GII/Hu/IN/2007/GII.P4_GII.4_

29573, 33983, 38393 DenHaag2006b/Pune-PC45

3114 VPI KP293589 3114 7524 11934. 16344, 20754, 25164, norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 29574, 33984, 38394 461

3115 VPI P24I908 3115 7525 11935, 16345, 20755, 25165, norovirus GII.4

29575. 33985, 38395

3116 VPI KJ45I059 3IIB 752B 11836. 16346, 20756, 25166, norovirus I3-BE-4/20I2/GII.4

2957B, 33986, 38396 3117 VPl KMI98570 3117 7527 11937, 16347, 2D757, 25IG7, norovirus Hu/GII/20146/2009/VNM

29577, 33987, 38397

3118 VPl KMI98558 3118 7528 11938, 16348, 20758. 25168, norovirus Hu/GII/30257/2009/VNM

29578, 33988, 38398

3119 VPl AB44745G 3119 7529 11939, 16349, 20759, 25169, norovirus Hu/GII-4/Sagal/2006/JP

29579, 33989, 38399

3I2D P! KFI77444 3I2D 753G 1(040, 16350, 20760, 25170, norovirus Hu/GII.4/36l26758/AUS/20l3

29580. 33990, 38400

3121 Pl KF42977G 3121 7531 11941, 16351. 20761. 25171. norovirus Hu/Gll.4/NIHICI7.I/20I2/0SA

29581, 33991, 38401

3122 VPl KC243078 3122 7532 11942, 16352, 20762, 25172, norovirus Hu/Gll.4/Taichung/I2-BA- 29582, 33992, 38402 I/20I2/TW

3123 VPl KC409280 3123 7533 11943, 16353, 20763, 25173, norovirus Hu/GII/20217/2009/VNM

29583, 33993, 38403

3124 VPl KC175357 3124 7534 11944, 16354, 20764, 25174, norovirus Hu/Narwalk/10148/2009/VN

29584, 33994, 384D4

3125 VPl JX459G2I 3125 7535 11945, 16355. 20765, 25175. norovirus Hu/GII.4/SG4045-07/2007/SG

29585, 33995, 38405

3I2G VPl JQG1354I 3126 753G 11946. 16356, 20766, 25176, norovirus Hu/GII.4/NSWI3IL/2009/A0

29586, 33996, 38406

3127 VPl JQGI3527 3127 7537 11947, 16357, 2D767, 25177, norovirus Hu/GII.4/NSW8Zi J/20D9/AU

29587. 33997, 38407

3128 VPl JF82729G 3128 7538 11948, 16358, 20768, 25178, norovirus

29588, 33998, 38408 Hu/GII.4/Houston/TCH492/2005/US

3129 VPl JF7I3050 3129 7539 11949, 16359, 20769, 25179, norovirus Hu/GII.4/Hong

29589, 33999, 38409 Kong/CUB00l/20l0/CHN

3I3D VPl HM802548 3130 7540 11950, 16360, 20770, 25180, norovirus Hu/GII.4/Hong

29590, 34000, 384ID ong/C0050l28/2005/CHN

3131 VPl GQ856459 3131 7541 11951. 16361. 20771. 25181, norovirus Hu/GII.4/Beijing/55l76/2008/CHN

29591.34001. 38411

3132 VPl AB54I308 3132 7542 11952. 16362, 20772, 25182, norovirus Hu/GII-4/Nagano5/2007/JP

29592, 34002, 38412

3133 VPl AB54I276 3133 7543 11953, 16363, 2D773, 25183, norovirus Hu/GII-4/lwate5/2008/JP

29593, 34003, 38413 3134 VPI AB54I224 3134 7544 11954, IB3B4, 2D774. 25184, narovirus Hu/GII-4/AamDri4/2007/JP

29594, 34004, 38414

3135 VPI AB5D4330 3135 7545 11955, IB3B5, 20775, 25185, norovirus Hu/Gli.4/Hiroshima/I54/2Q08/JPN

29595, 34005, 38415

3I3B VPI AB447445 3I3B 754B 11956. IB3BB, 2077B, 25I8B, narovirus Hu/GII-4/Tnyama5/2D06/JP

29596, 3400B, 384IB

3137 VPI AB2947B3 3137 7547 11957, IB3B7, 20777, 25187. narovirus Hu/GII- 29597, 34007, 38417 4/Kashiwa/06l256/2006/JP

3138 VPI AB3D3934 3138 7548 11958, IB368, 20778, 25188, noravirus Hu/GGII.4/DenHelder003/2004/NL

29598, 34008, 38418

3139 VPI KUB782D5 3139 7549 11959, 16369. 20779, 25189, narovirus l6-J-l/20IB/GII,Pe/GII.4

29599, 34009.38419 Sydney_20l2

3I4D VPI LCI77B57 3I4B 755B 11960, 16370, 20780, 25190, noravirus GII.4

29600, 34010, 38420

3141 VPI LCI77B5B 3141 7551 11961, 16371, 20781, 25191, noravirus GII.4

29601, 34011.38421

3142 VPI KX354I36 3142 7552 11962, 16372, 20782, 25192, norovirus GII.4

29602, 34012, 38422

3143 VPI KX354I2I 3143 7553 11963, 16373, 20783, 25193, narovirus GII.4

29603, 34013, 38423

3144 VPI KX354II0 3144 7554 11964. IB374, 20784, 25194, norovirus GII.4

29604, 34014, 38424

3145 VPI KX354IB7 3145 7555 11965. 16375, 20785, 25195, narovirus GII.4

29605, 34015, 38425

3I4G VPI X35399I 3I4B 755B II96B, 16376, 20786, 25196, norovirus GII.4

29606, 34016, 3842B

3147 VPI U985IB2 3147 7557 11967. 16377, 20787. 25197. narovirus GII.4

29G07.34017. 38427

3148 VPI AB97247B 3148 7558 11968, IB378, 20788, 25198, noravirus Hu/GII.4/Toyama2/20l2/JP

29608, 34018, 38428

3149 VPI KU3II162 3149 7559 11969, IB379, 20789, 25198. norovirus Hu/GII.4/AlbertaSPI/20l2/CA

29609, 34019, 38429

3I5D VPI R9042I2 3I5D 75BB II97D, 16380, 20790, 25200, norovirus Gil

29610, 34020, 38430 3151 VPI AB933B78 3151 75BI 11971. 16381. 20791, 252DI, narovirus Hu/6ll.4/Niigata4/20ID/JP

29611, 34021, 38431

3152 VPI ABB33B48 3152 75B2 11972, 16382, 20792, 25202, narovirus Hu/GII.4/Aornori2/2009/JP

29612, 34022, 38432

3153 VPI LN85457I 3153 75B3 11973, 16383, 20793, 25203, nnrovirus Gll/Hu/NL/20l2/Gli.4/NijmegBnOI

29BI3, 34023. 38433

3154 VPI EU92I384 3154 75B4 11074, IB384. 20794. 25204, norovirus GII/Hu/IN/2DD7/GII.P4_GII.4_

29614, 34024, 38434 DenHaag2006b/Pune-PC47

3155 VPI LC0D57IB 3155 75B5 11975, IB385, 20795, 25205, norovirus GII/Hu/JP/20l2/GII,4/yll-V664-l

29BI5, 34025, 38435

3156 VPI KP241BI4 3I5B 75BB 11976, 16386, 20796, 25206, norovirus GII.4

296IB, 34026, 38436

3157 VPI KJ4330B8 3157 75G7 11977, 16387, 20797. 25207, norovirus I2-AS-I/2DI2/GII.4

29617, 34027, 38437

3158 VPI PI7B4B9 3158 75B8 11978, IB388, 20798, 25208, norovirus Hu/GII/HKG 2DI4/GII.4/CUHK-NS- 29618, 34028, 38438 430

3159 VPI KM5I4DB4 3159 75B9 11979, 16389, 20799, 25209, norovirus GII/Hu/H G/2DI4/GII.4/CUHK-NS- 29619, 34029, 38439 319

3IBD VPI KJB497D3 3IBB 7570 11980, 16390, 20800, 25210, norovirus GII/Hu/HKG/2DI4/GII.4/CUHK-NS- 29B20. 34030, 38440 246

3IBI VPI KFI77447 3IBI 7571 113S1. 16391. 20801, 25211, norovirus Hu/GII.4/3D996947/AUS/2DI2

29621. 34031. 38441

3IB2 VPI JX43982B 3IB2 7572 11982, 16392, 20802, 25212, norovirus HU/GII/SEOUII033/KDR/2DI0

29B22, 34032, 38442

3IB3 VPI HF952I2D 3IB3 7573 11983, IB393, 20803, 25213, norovirus Hu/GII.4/CD0007876/20ll/0K

29623, 34033, 38443

3IB4 VPI KC5I7369 3IB4 7574 11984, 16394, 20804, 25214, norovirus Hu/GII- 29624, 34034, 38444 4/Taoyuan/CGMH59/20l2/TW

3IB5 VPI KC409293 3IB5 7575 11985, IB395, 20805, 25215, norovirus Hu/GII/20365/2DIO/VN

29625, 34035, 38445

3IBB VPI JX98495I 3IBB 757B 11986, 16396, 2080B, 2521B, norovirus Hu/GII.4/GZ20IO- 29626, 34036, 3844B L88/Guangzhou/CHN/20II

3IB7 VPI JX459BI2 3IB7 7577 11987, IB397, 20807, 25217, norovirus Hu/Gll.4/SG4058-I2/200G/SG

29627, 34037, 38447 3168 VPI JX459BD4 3IB8 7578 11988, IB398, 20808, 25218, norovirus Hu/Gll.4/SG4024-I0/2006/SG

29B28, 34038, 38448

3IB8 VPI JXI55745 3IB9 7579 11989, 16399, 20809, 25219, noPDvirus Hu/GII.4/Xi an/PI58/2OI0/CHN

29B29, 34039, 38449

3I7D PI HMB35I55 3170 7580 11990, 16400, 20810, 25220. norovirus Hu/GII.4/Seoul/090Z/Z009/K0

29630, 34040.38450

3171 VPI JN400G2D 3171 7581 11991, 16401. 20811, 25221, norovirus Hu/Gli-4/CGMH22/20IO/TW

29B31.34041, 38451

3172 VPI JQ6I3573 3172 7582 11992, IB402, 20812, 25222, narovirus

29632, 34042, 38452 Hu/Gll.4/Helensburgh/NSW2B5E/20I0/A0

3173 VPI JQ4784D8 3173 7583 11993, 16403, 20813, 25223, naravirus Hu/GII.4/Farmington

29633.34043.38453 Hills/2004/0SA

3174 VPI EFG849I5 3174 7584 11994, IG404, 20814, 25224, narovirus

29B34, 34044, 38454 Hu/GII.4/ShBllharbour/NSW69GT/20D6/AUS

3175 VPI HQ45B33I 3175 7585 11995, 16405, 20815, 25225, narovirus Hu/GII.4/07-H-3/20D6/TW

29635, 34045, 38455

3I7B VPI HQ45B322 3I7B 758B 11996, 16406, 20816, 25226, naravirus Hu/GII.4/06-AM-2/2006/TW

29636, 3404B, 38456

3177 VPI HM80255I 3177 7587 11997, 16407, 20817, 25227, narovirus Hu/GII.4/Hong

29637, 34047, 38457 ong/CU04l222/2004/CHN

3178 VPI HM802546 3178 7588 11998, IB408, 20818, 25228, norovirus Hu/GII.4/Hong

29B38, 34048, 38458 ang/CU04l20G/2004/CHN

3179 VPI GQ85B453 3173 7589 11999, 16409, 20819, 25229, norovirus Hu/GII.4/Beijing/55D47/ZDD7/CHN

29639, 34049, 38459

3180 VPI GQ856445 3180 7590 12000, 16410. 2D820, 25230, norovirus Hu/GII.4/Beijing/53952/2007/CHN

29640, 34050, 38460

3181 VPI AB54I358 3181 7591 12001, 16411, 20821, 25231, norovirus Hu/GII-4/Toyama3/2008/JP

29641, 34051, 38461

3182 VPI AB54I349 3182 7592 12002, 16412, 20822, 25232, norovirus Hu/GII-4/ShimanE3/2Q07/JP

29642, 34052, 38462

3183 VPI AB54I342 3183 7593 12003, 16413, 20823, 25233, narovirus Hu/GII-4/Sakai3/2007/JP

29643, 34053.38463

3184 VPI AB54I248 3184 7594 12004, 16414, 20824, 25234, narovirus Hu/GII-4/Fukui4/2008/JP

29644, 34D54, 38464 3185 VPI GD24G798 3185 7595 12005, IB4I5. 20825, 25235, nDrovirus Hu/GGII.4/Dijon/E3743/ZDD9/F A

29645, 34055, 384B5

3I8B VPI GQ24G79I 3I8B 759B I200B, 16416, 2082B, 2523G, nopovirus Hu/GGII.4/Dijon/E302D/ZD0B/FRA

29646.34056, 38466

3187 VPI GU350225 3187 7597 12007, 16417, 20827, 25237, norovirus Hu/GII-4/Beijing/hl/2005/CHN

29647, 34057, 38467

3188 VPI AB5D43I9 3188 7598 12008. 16418, 0828, 25238, norovirus Hu/GII.4/Hiroshima/74/2D0G/JPN

29648, 34058, 38468

3189 VPI AB447458 3189 7599 12009, 16419, 20829, 25239, norovirus Hu/GII-4/Saga5/2006/JP

29649, 34059, 38469

3190 PI AB385B4Q 3I9D 7B00 12010, 16420, 20830, 25240. norovirus

29650, 340B0, 38470 Hu/GII.4/RotterdamP7Dlia/2D07/NL

3191 VPI AB385B33 3191 7B0I 12011, 16421, 20831, 25241, norovirus

29651, 34061, 38471 Hu/GII.4/RottErdamP4D33/2D0B/NL

3192 VPI DQ6584I3 3192 7B02 12012, 16422, 20832, 25242, norovirus Hu/GII.4/MD-2004/2004/US

29652, 34062, 38472

3193 VPI AB22D923 3193 7B03 12013, 16423, 20833, 25243, norovirus Hu/Ehime/05-30/2005/JP

29653, 34063, 38473

3194 VPI AY5880IB 3194 7B04 12014, 16424, 20834, 25244, norovirus Hu/NLV/0xford/85S9/2002/0K

29654, 34064, 38474

3195 VPI AY5D2D22 3195 7B05 12015, 16425, 20835, 25245, norovirus Gil

29B55, 34065, 38475

3196 VPI KXI58280 3I9B 7B0B 12016, 16426, 2D836, 25246, norovirus Gil

29656, 34066, 3847B

3197 VPI KX37IB0E 3197 7B07 12017, 16427, 20837, 25247, norovirus GII.4

29657, 34067, 38477

3198 VPI KX37IBD5 3198 7B08 12018. 16428. 20838, 25248. norovirus GII.4

29658, 34068.38478

3199 VPI KX354I28 3199 7B09 12019, 16429, 20839, 25249, norovirus GII.4

29G59, 34069, 38479

32DD VPI KX35409B 3200 7BI0 12020, 16430, 20840, 25250, norovirus GII.4

29660, 34070, 38480

32DI VPI KX354087 3201 7BII 12021, 16431, 20841, 25251, norovirus GII.4

29661. 34071.38481 3202 VPI X354009 3202 7BI2 12022. IG432, 20842, 25252, namvirus GII.4

29BB2, 34072, 38482

3203 VPI KRI3I784 3203 7613 12023, IB433, 20843, 25253, norovirus GII/Hu/IN/2DI3/GII.PE_GII.4_

29BG3, 34073, 38483 Sydn _E y20l2/PunB-l36935

3204 VPI AB972527 3204 7BI4 12024, IG434, 20844, 25254, noravirus Hu/GII.4/0sakaCity3/20l2/JP

29GB4, 34074, 38484

3205 VPt ABB72525 3205 7BI5 12025, IB435, 20845, 25255, noravirus Hu/BII.4/Toyama4/2DIZ/JP

29BB5, 34075, 38485

320G VPI KT780388 320B 7BIB I202B, IB43B. 2084B, 2525B, namvirus Hu/GII.4/CUHK-NS-GI8/HKG/ZDI5

29BBB, 3407B, 3848B

3207 VPI T780373 3207 7BI7 12027, IB437, 20847, 25257, noravirus HU/GII.4/C0HK-NS-5I6/HKG/20I5

23BB7, 34077, 38487

32D8 VPI AB933723 32D8 7BI8 12028, IB438, 20848, 25258, namvirus Hu/GII.4/Saga3/20ll/JP

20BB8, 34078, 38488

3209 PI AB833708 3209 7BIB 12029, IB439, 20849, 25259, noravirus Hu/GII.4/Hiroshimacity3/20ll/ JP

2BBB9, 34079, 38489

3210 VPI LC0BBB4B 3210 7G20 12030, IB44D, 20850. 252B0, noravirus

29B70, 34080, 38490 Hu/GII/JP/20l5/GII.Pe_GII.4/0saka/0SF78

3211 VPI KJB78I40 3211 7B2I 12031, 16441. 20851, 252BI, namvirus Hu/GII.4/Beijing/PK0PH-02- 29671, 34081, 38491 07/inpati _E nt/20l3/CHN

3212 VPI KJ678I39 3212 7B22 12032. 16442, 20852, 25262, namvirus Hu/GII.4/Beijing/PKUPH-02- 29672, 34082, 38492 06/inpatiEnt/20l3/CHN

3213 PI E0B2I383 3213 7B23 12033, 16443, 20853, 252B3, noravirus GII/Hu/IN/2007/GII.P4_GII.4_

29B73, 34083, 38493 DenHaag2006b/PunE-PC46

3214 VPI KPI76405 3214 7B24 12034, IB444, 20854, 25264, namvirus Hu/GII/HKG/ZOI4/GII.4/CUHK-NS- 29674, 34084, 38494 418

3215 VPI PI7B403 3215 7B25 12035, 16445, 20855, 25265. namvirus Hu/GII/H G/ZDI4/GII.4/CUH -NS- 29675, 34085, 38495 416

3216 VPI KP086343 32IG 7B2B 12036, IB446, 20856, 252BB, namvirus Hu/GII/HKG/ZGI4/GII.4/CUHK-NS- 29B76, 34086, 38496 397

3217 VPI KM268I0I 3217 7B27 12037, 16447, 20857, 25267, namvirus GII.4

29677, 34087, 38497 3218 VPI MI985G8 3218 7628 12038, 16448, 0858, 5268, narovirus Hu/GII/C2H-G2/20ll/VNM

29678, 34088, 38498

3219 VPt KMI98532 3219 7G29 12039, 16449, 20859, 252GB. nomvirus Hu/GII/IOID8/2009/VNM

29679, 34089, 38499

322D VPI MI98527 322G 7630 I2D40, 16450, 20860, 25270, narovirus Hu/GII/10074/2009/VNM

29680, 34090, 38500

3221 VPI KFI77448 3221 7631 12041. 16451, 20861. 25271, norovirus Hu/GII.4/35408489/AUS/20l2

29681, 34091, 38501

3222 VPI KFD08244 3222 7632 12042, 16452, 20862, 25272, narovirus Hu/GII.4/ variant Sydney 2012/FRA

29682, 34092, 38502

3223 VPI KF0G0I03 3223 7633 12043, 16453, 20863, 25273, norovirus Hu/GII.4/NSW8IIG/20ll/A0

29683. 34003.38503

3224 VPI KC9606I5 3224 7634 12044, 16454, 20864, 25274, norovirus Hu/GII.4/20l99/2009/VNM

29684, 34094, 38504

3225 VPI C5I7373 3225 7635 12045, 16455, 2D865, 25275, noravirus Hu/GII- 29685, 34095, 38505 4/Taayuan/CGMH63/20l2/TW

3226 VPI JX4596I5 322B 7636 12046, 16456, 20866, 25276. norovirus Hu/GII.4/SG40IO-OI/2007/SG

29686, 34096, 38506

3227 VPI JX459GD3 3227 7637 12047, 16457. 20867, 25277. norovirus Hu/GII.4/SG4OI9-09/2DO6/SG

29687, 34097, 38507

3228 VPI JXI5574G 3228 7638 12048. 16458, 0868, 25278, norovirus Hu/GII.4/Xi'an/PI85/20IO/CHN

29688.34098.38508

3229 VPI AB54I333 3229 7639 12049, 16459, 20869, 25279, norovirus Hu/GII-4/Saga2/2008/JP

29689, 34099.38509

323D VPI AB54I22Q 323D 7640 12050. 16460. 20870, 25280, norovirus Hu/GII-4/Aomori2/2007/JP

29690, 34100, 38510

3231 VPI AB5D43I2 3231 7641 12051, 16461, 20871, 25281, norovirus Hu/GII.4/Hiroshima/57/2005/JPN

29691, 34101.38511

3232 VPI GQ849I2G 3232 7642 12052, 16462. 20872. 25282, norovirus Hu/GII.4/NSW023C/2008/A0S

29692, 34102, 38512

3233 VPI AB447459 3233 7643 I2D53, 16463, 20873, 25283, norovirus Hu/GII-4/Kumamotol/200G/JP

29693, 34103, 38513 3234 VPI EUD784I3 3234 7B44 12054. IB4B4, 20874, 25284, norovirus Hu/GA04/2004/USA

29B94, 34104, 38514

3235 VPI EU0784II 3235 7B45 12055, IB4B5, 20875. 25285. nnrovirus Hu/OM2-CS/2004/0SA

29B95, 34105, 38515

323B VPI AB385B32 323B 7B4B I205B. IB4BB, 2087B, 2528B, norovirus Hu/GII.4/RotterdamP4D0/20Q6/Nl

29696, 34I0B, 385IB

3237 VPI EU839595 3237 7B47 12057, 16467, 20877, 25287, norovirus Hu/GII/Beijing/362/2007/CHN

29697, 34107, 38517

3238 VPI AB294788 3238 7B48 12058, 164B8, 20878. 25288, norovirus Hu/GII-4/Sanbu/050878/200B/JP

29698, 34108, 38518

323B VPI AB3D393B 3239 7B49 12059, 16469, 20879, 25289, nnrovirus Hu/GGII.4/ElslnoOI2/2004/NL

29699, 34109, 38519

3240 PI AB3D3935 324D 7B5B 12060, IB470, 20880, 25290, norovirus Hu/GGII,4/ iddBlburgD07/2004/NL

29700, 34110, 38520

3241 VPI AY588DI8 3241 7B5I 12061. 16471. 20881. 25291, norovirus Hu/NLV/0xford/B5SI3/2002/0K

29701, 34111, 38521

3242 VPI KU678203 3242 7B52 12062, 16472, 20882, 25292, norovirus I5-J0-2/20I6/GIIJVGII.4

29702, 34112, 38522 Sydney_20l2

3243 VPI KPI7B4I0 3243 7B53 I20B3, IB473, 2D883, 25293, norovirus Hu/6ll/HKG/ZDI4/GII.4/CUH -NS- 29703, 34113, 38523 431

3244 VPI KX371B0B 3244 7B54 12064, IB474, 2B884, 25294, nnrovirus GII.4

29704, 34114, 38524

3245 VPI KX354I30 3245 7B55 I20B5, IB475. 20885. 25295. norovirus GII.4

29705, 34115, 38525

324B VPI KX354I20 324B 7B5B I20B6, 1647B, 2088B. 25296, norovirus GII.4

2970B, 34116.38526

3247 VPI KX354II3 3247 7B57 I20B7. IB477, 20887, 25297, norovirus GII.4

29707, 34117, 38527

3248 VPI KX354I05 3248 7B58 12068, 16478, 20888, 25298. norovirus GII.4

29708.34118. 38528

3240 VPI KX354077 3249 7B59 12069, 16479, 20889, 25299, norovirus GII.4

29709, 34119, 38529 3250 VPI KRI3I785 3250 7BB0 I207D, IG480, 20890, 25300, norovirus GII/Hu/IN/ZDI3/GII.Pe_GII.4_

29710, 34120, 38530 Sydn _E y20l2/Pune-l3243l8

3251 VPI AB97253D 3251 7BBI 12071. 16481, 208BI, 25301, norovirus Hu/GII,4/Hiroshima3/20l2/JP

29711, 34121, 38531

3252 VPI AB97252B 3252 7BB2 12072, IB482, 20892, 25302, norovirus Hu/GII.4/Fukui5/20IZ/JP

29712, 34122, 38532

3253 VPI AB972522 3253 7BB3 12073, IB483, 20893, 25303, norovirus Hu/GII.4/Niigata2/Z01Z/JP

29713, 34123, 38533

3254 VPI ABB725I4 3254 7BB4 12074, IB484. 20894, 25304, norovirus Hu/GII.4/lwatel/20l2/JP

29714, 34124, 38534

3255 VPI AB9725D5 3255 7BB5 12075, IB485, 20895, 253D5, norovirus Hu/GII.4/GII4-NGI3B5/20ll/JP

29715.34125, 38535

325B VPI AB972473 325B 7BBB I207B, IB48B. 2089B, 2530B, norovirus Hu/GH.4/lwate5/20l2/JP

297IB, 34I2B, 3853B

3257 VPI T78D38I 3257 7BB7 12077, IB487, 20897, 25307, norovirus Hu/GII.4/C0H -NS-554/HKG/2DI5

29717, 34127, 38537

3258 VPI KT780372 3258 7BB8 12078, IB488, 20898, 25308, norovirus Hu/GII.4/CUHK-NS-5l5/HKG/2DI5

29718. 34128, 38538

3259 VPI KT202797 3259 7BB9 12079. IB489, 20899, 25300. norovirus Gil

29719, 34129.38539

32B0 VPI R9D422G 32B0 7B70 12080. 16490, 20900, 25310. norovirus Gil

29720. 34130, 38540

32BI VPI R904208 32BI 7B7I 12081. 16491, 20901, 25311, norovirus Gil

29721, 34131, 38541

32B2 VPI AB9337D9 32B2 7B72 12082, 16492, 20902, 25312, norovirus Hu/GII.4/Hokkaidol/2DII/JP

29722, 34132. 38542

32B3 VPI EU92I352 32B3 7B73 12083, IB493, 20903, 25313, norovirus GII/Hu/IN/200G/GII.P4_GII,4_

29723.34133. 38543 Yerseke20Q6a/Pune-PC23

32B4 VPI LCQD5735 32B4 7B74 12084, IB494, 0904, 25314, norovirus GII/Hu/JP/20l4/GII.4/yl3-VI010-l

29724, 34134, 38544

32B5 VPI KP24I909 32B5 7B75 12085, 16495, 20905. 25315. norovirus GII.4

29725, 34135, 38545 3266 VPI KJ533I32 3266 7676 12086, 16496, 20906, 25316, noravirus I2-BA-I/20I2/GII.4

29726, 34136, 38546

3267 VPI PI76407 3267 7677 12087, 16497, 20907, 25317, norovirus Hu/GII/HKG/20l4/GII.4/C0H -NS- 29727, 34137, 38547 421

3268 VPI KPI76406 3268 7678 12088, 16498, 20908, 25318, norovirus Hu/GII/HKG/20l4/GII.4/CUH -NS- 29728, 34138, 38548 420

3269 VPI KPI23606 3269 7679 12089, 16499, 20909, 25319, norovirus Hu/GII/H G/20l4/GII.4/C0H -NS- 29729.34139, 38549 426

3270 VPI P096335 3270 7680 12090, 16500, 20910, 25320, norovirus Hu/GII/H G/2DI4/GII.4/CUH -NS- 29730, 34140, 38550 385

3271 VPI KM268095 3271 7681 12091, 16501, 20911, 25321, norovirus GII.4

29731, 34141, 38551

3272 VPI M268094 3272 7682 12092, 16502, 20912, 25322, norovirus GII.4

29732, 34142, 38552

3273 VPI M268093 3273 7683 12093, 16503, 20913, 25323, norovirus GII.4

29733, 34143, 38553

3274 VPI KMI9859I 3274 7684 12094, 16504, 20914, 25324, norovirus Hu/GII/20122/2009/VNM

29734, 34144, 38554

3275 VPI KMI98589 3275 7685 12095, 16505, 20915, 25325, norovirus Hu/GII/20144/2009/VNM

29735, 34145, 38555

3276 VPI KM1B857B 3276 7686 12096, 16506, 20916, 25326, norovirus Hu/GII/C2H-43/20ll/VNM

29736, 34146, 38556

3277 VPI KMI98564 3277 7687 12097, 16507, 20917, 25327, nurovirus Hu/GII/C2H-44/20ll/VNM

29737, 34147, 38557

3278 VPI KJ7I6355 3278 7688 12098, 16508, 20918, 25328, norovirus Hu/GII.4/Beijing

29738, 34148, 38558

3279 VPI KJ685408 3279 7689 12099, 16509, 20919, 25329, norovirus Hu/GII/BGIC0066/20ll/BGD

29739, 34149, 38559

328D VPI JI44909 3280 7690 12100, 16510, 20920, 25330, norovirus GII.4

29740, 34150, 38560

3281 VPI KF0600I6 3281 7691 12101, 16511, 20921, 25331, norovirus Hu/GII.4/NSWI749/20ll/AU

29741, 34151, 38561

3282 VPI KC5I7367 3282 7692 12102, 16512, 20922, 25332, norovirus Hu/GII- 29742, 34152, 38562 4/Taoyuan/CGMH57/20l2/TW 3283 VPI C5I7366 3283 7B93 12103, 16513, 20323, 25333, norovirus HU/GII-4/NEW

23743, 34153, 38563 Taipei/CGMH56/20IZ/TW

3284 VP! C5I7353 3284 7S94 12104, 16514, 20924, 25334, norovirus Hu/GII-4/New

29744, 34154, 38564 Taipei/CGMH49/20ll/TW

3285 VPI KC4G9303 3285 7695 12105, 16515. 20325, 25335, norovirus Hu/GII/20478/2010/VNM

23745, 34155, 385B5

328B VPI JX453BD8 328B 7B9B 12106, 16516. 2D926, 2533B, norovirus Hu/GII.4/SG4097-ID/200B/SG

2974B, 34156, 38566

3287 VPI J0320073 3287 7B37 12107, 16517. 20327, 25337, norovirus Hu/GII.4/NF2003/USA/2003

23747, 34157, 385B7

3288 VPI HM8D2552 3288 7B98 12108, 16518, 2D328, 25338, norovirus Hu/GII.4/Hong

23748, 34158, 38568 Kong/CUQ50S52/2D05/CHN

3289 PI AB54I32B 328S 7633 12103, 16519. 20329, 25333, norovirus Hu/GII-4/0sakal/2008/JP

23743, 34159, 38563

32BD VPI AB54I227 3230 7700 12110, 16520, 20B30, 25340, norovirus Hu/GII-4/Aomori5/2008/JP

23750, 34IB0, 38570

3291 VPI AB5G43I8 3231 7701 I2III. 16521, 20B3I, 25341, norovirus Hu/GII.4/Hiroshima/69/2006/JPN

29751, 34161, 38571

3232 VPI AB5D43II 3232 7702 12112, 16522, 20332, 25342, norovirus Hu/6ll.4/Hiroshima/56/2005/JPN

29752, 34IB2, 38572

3293 VPI FJ537I35 3233 77D3 12113, IB523, 20933, 25343, norovirus Hu/Gll.4/CHDC2094/I974/0S

29753, 34163. 38573

3234 VPI G04I3S63 3294 7704 12114, IB524. 20934, 25344. norovirus Hu/GII.4/Rivieral635/2008/US

23754, 34IB4. 38574

3235 VPI EU833532 3235 7705 12115, IB525, 20335. 25345, norovirus Hu/Bll/BEijing/l27/20D7/CHN

23755, 34165, 38575

323B VPI EU833587 3236 770B 12116. IB52B, 20336, 25346, norovirus Hu/GII/BEijing/493/2005/CHN

23756, 34I6B, 38576

3237 PI EU833583 3237 7707 12117. 16527, 20337, 25347, norovirus Hu/GII/Beijing/79/2004/CHN

29757, 34167, 38577

3298 VPI AB3B393I 3238 7708 12118, 16528, 20938, 25348, norovirus Hu/GGII.4/ApeldoornDZ3/Z003/NL

29758. 34IB8, 38578

3233 VPI Y34I923 3299 7709 12119, IB529. 20939, 25349, norovirus GII.4

29759, 34169, 38579 3300 VPI KX5I43I7 3300 7710 12120. IG530. 20940. 25350, norovirus GII.4

29760, 34I7D, 38580

3301 VPI 0G78204 3301 7711 12121, 16531, 20941, 25351. norovirus l6-C-2/20IG/GII.Pe/GII.4

297GI, 34171, 38581 Sydney_2DI2

330Z VPI KXI58283 3302 7712 12122, IG532, 20942, 25352, norovirus Gil

29762.34172, 38582

3303 VPI X354088 3303 7713 12123, 16533, 20943, 25353, norovirus GII.4

29763.34173. 38583

3304 PI KX354032 3304 7714 12124. 16534. 20944, 25354, norovirus GII.4

297G4, 34174, 38584

3305 VPI KX3540I5 3305 7715 12125, IG535, 20945. 25355, norovirus GII.4

29765, 34175, 38585

330G VP! X35393B 330G 77IG 12126, 16536, 20946, 25356, norovirus Gl!.4

29766.34176, 38586

3307 VPI KX353987 3307 7717 12127, 16537, 20947, 25357, norovirus GII.4

29767, 34177, 38587

3308 VPI KX353970 3308 7718 12128, 16538. 20948. 25358, norovirus GII.4

29768, 34178, 38588

3309 VPI KU985I5G 3309 7719 12129, 16539, 20949, 25359, norovirus GII.4

29769, 34179, 38589

33ID VPI KU885I55 3310 7720 12130, 16540, 20950. 25360, norovirus GII.4

29770, 34180, 38590

3311 VPI KM5I4075 3311 7721 12131, 16541, 2D95I, 25361, norovirus GII/Hu/H G/2DI4/GII.4/CUH -NS- 29771, 34181, 38591 332

3312 VPI AB972484 3312 7722 12132, 16542, 20952, 25362, norovirus Hu/GII.4/QsakaCityl/20l2/JP

29772, 34182.38592

3313 VPI KT78D39I 3313 7723 12133, 16543. 20953, 25363, norovirus Hu/GII.4/CUHK-NS-660/HKG/20l5

29773, 34183, 38593

3314 VPI T780390 3314 7724 12134, 16544, 20954, 25364, norovirus Hu/GII.4/C0HK-NS-652/HKG/20l5

29774, 34184, 38594

3315 VPI T78037G 3315 7725 12135, 16545, 20955, 25365, norovirus Hu/GII.4/C0H -NS-526/HKG/20l5

29775, 34185.38595

3316 VPI KT780375 3316 772G 12136, 16546, 20956. 25366, norovirus Hu/GII.4/C0H -NS-525/HKG/20l5

28776.34186, 38596 3317 VPI LC0IBB07 3317 7727 12137. IB547, 20957, 253B7, norovirus Hu/JP/2004/GII.4/Sakai/OI- 29777, 34187, 38597 inpatient8-54d-2

3318 VP1 KP24I9I5 3318 7728 12138, IB548, 20958. 253B8, norovirus GII.4

29778, 34188. 38598

3319 VPI M5I40B5 3319 7729 12139, IB549, 20959, 25369, norovirus GII/Hu/HKG/20l4/GII.4/CUH -NS- 29779, 34189, 38599 320

3320 VPI M268097 3320 7730 12140, 16550, 209BD, 25370, norovirus GII.4

29780, 34190, 38B00

3321 VPI KM268084 3321 7731 12141, 16551, 20961, 25371, norovirus GII.4

29781, 34191, 38601

3322 VPI JB49704 3322 7732 12142, IB552, 20962. 25372, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29782, 34192, 38602 Z50

3323 VPI KC577I74 3323 7733 12143, 16553, 20963, 25373, norovirus Hu/GII.4/Jiangsul/20ll/CHN

29783, 34193, 38603

3324 VPI FI7745I 3324 7734 12144, 16554, 209B4, 25374, norovirus Hu/GII.4/34790954/AUS/20l3

29784, 34194, 38B04

3325 VPI FI77429 3325 7735 12145, IB555. 20965, 25375, norovirus Hu/GII.4/35444252/AUS/20l2

29785. 34195, 38B05

3326 VPI KF0B0005 332B 773B 12146. IB556, 20966. 2537B, norovirus Hu/GII.4/NSW0979/20l2/AU

2978B, 34I9B, 3860B

3327 VPI JX43982I 3327 7737 12147, IB557, 20967. 25377, norovirus HU/GII/SBOUM0SB/ DR/2DI0

29787, 34197, 38B07

3328 VPI C5I73BI 3328 7738 12148, 16558, 20968. 25378, norovirus Hu/GII- 29788, 34198, 38608 4/Taoyuan/CGMH5l/20l2/TW

3329 VPI CI75378 3329 7739 12149, IB559, 20969, 25379, norovirus Hu/Norwalk/I0247/2009/VNM

29789, 34199, 38B09

3330 VPI JX459648 3330 7740 12150, 16560, 20970, 25380, norovirus Hu/Gll.4/SG4058-I0/2009/SG

29790. 34200, 38610

3331 VPI JX459635 3331 7741 12151, 16561, 20971, 25381. norovirus Hu/GII.4/SG406l-OI/2009/SG

29791, 34201. 38611

3332 VPI JX459B24 3332 7742 12152, 16562, 20972. 25382, norovirus Hu/GII.4/SG4075-08/2007/SG

29792. 34202, 38BI2

3333 VPI JX4596I4 3333 7743 12153, IB563, 20973, 25383, norovirus Hu/GII.4/SG4007-OI/2007/SG

29793, 34203, 38BI3 3334 VPI HMB35I03 3334 7744 12154, IB5B4, 20974, 25384, narovirus Hu/GII.4/Seoul/OB52/20IO/KO

29794, 34204, 38BI4

3335 PI JQGI3522 3335 7745 12155, IB5B5, 20975, 25385, narovirus Hu/GII.4/NSW7B4D/2008/AO

29795, 342D5, 38BI5

333B PI ABB29942 333B 774B 12156. IB5BB, 2097B, 2538B, noravirus Hu/Tokyo/lD-2D/2DtD/JPN

2979B, 3420G, 38BIB

3337 VPI GQ85B457 3337 7747 12157, IB5B7. 20977, 25387, narovirus Hu/GII.4/BBijing/55l50/2008/CHN

29797, 34207, 38BI7

3338 VPI EU87B883 3338 7748 12158, IB5B8, 20978, 25388, noravirus Hu/GGII,4/Cairo3/200B/EGY

29798, 34208, 38BI8

333B VPI AB447455 3339 7749 12159, 16569, 20979, 5389, narovirus Hu/GII-4/Enime5/2006/JP

29799, 34209, 38619

3340 VPI EUD78409 334D 7750 12160, 16570, 20980, 25390, noravirus Hu/WarrBn/2002/USA

29800, 34210, 38620

3341 VPI AB303928 3341 7751 12161, 16571, 20981, 25391, noravirus Hu/BBII.4/WeertE022/2002/NL

29801, 34211, 38621

3342 VPI AY502023 3342 7752 12162, IB572, 20982, 25392, noravirus Gil

29802, 34212, 38622

3343 VPI KU678202 3343 7753 12163, 16573, 20983, 25393, noravirus I5-IZ-I/20I5/GII.PB/GII.4

29803, 34213, 38623 Sydney_2DI2

3344 VPI X37IB07 3344 7754 12164, IB574, 20984, 25394, norovirus GII.4

29804, 34214, 38B24

3345 VPI KX354II2 3345 7755 I2IB5, IB575, 20985, 25395, narovirus GII.4

29805, 34215, 38B25

334B VPI KX353993 334B 775B I2IB6, 16576, 20986, 25396, narovirus GII.4

29806, 34216, 38B2B

3347 VPI KRI3I7B2 3347 7757 12167, 16577, 20987, 25397, norovirus GII/Hu/IN/2007/GII.P4_GII.4_

29807, 34217, 38627 DBnHaag2006b/Pune-07l6584

3348 VPI ABB725I9 3348 7758 12168, 16578, 20988, 25398, noravirus Hu/GII.4/Aichi5/2DI2/JP

29808, 34218, 38628

3349 PI AB972438 3349 7759 12169, 16579, 20989, 25399, noravirus Hu/GII.4/Ehime3/2DI2/JP

29809, 34219, 38B29

3350 VPI AB972488 3350 77BD 12170, IB580, 20990, 2540D, noravirus Hu/GII.4/Sakai2/2DI2/JP

29810, 34220, 38B30 3351 VPI AB072483 3351 7761 12171, 16581. 20991. 25401, norovirus Hu/GII.4/Ehime5/20l2/JP

29811.34221, 38631

3352 VPI KP8B4I0B 3352 7762 12172, IB582, 20992. 25402, norovirus GII.4

29812, 34222, 38632

3353 VPI K B042I6 3353 77B3 12173, 16583, 20993, 25403, norovirus Gil

29813, 34223, 38633

3354 VPI AB93377I 3354 77B4 12174, 16584, 2D994, 25404, norovirus Hu/GII.4/Hiroshimacityl/20ll/ JP

29814, 34224, 38634

3355 VPI LC005732 3355 7765 12175, 16585, 20995, 25405, norovirus GII/Hu/JP/20l3/GII.4/yl3-V938-3

29815, 34225, 38B35

335G VPI KP29359I 335B 7766 12176. 16586, 20996, 25406, norovirus BII/Hu/H G/ZDI4/GII.4/CUH -NS- 29816, 34226, 38636 464

3357 VPI PI7B3B6 3357 7767 12177, IB587, 20997, 25407, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 29817, 34227, 38B37 35B

3358 VPI KPI76394 3358 7768 12178, IB588, 20998, 25408, norovirus Hu/GII/H G/ZOI4/GII.4/CUHK-NS- 29818, 34228, 38638 346

3358 VPI KP096348 3359 7769 12179, IB589, 20999, 25409, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 298IB, 3422B, 38639 40B

3360 VPI KP096344 33B0 7770 12180, IB590, 21000, 25410, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 2982D, 34230, 38640 398

336! VPI KM98294B 33BI 7771 12181, 16591, 21001, 25411, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29821, 34231, 38641 357

3362 VPI KM5I4070 33B2 7772 12182, 16592, 21002, 25412. norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 29822, 34232, 38642 327

3363 VPI KM51406I 33B3 7773 12183, 16593, 21003, 25413, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29823, 34233, 38643 316

3364 VPI KM5I4DBD 33B4 7774 12184, 16594, 21004, 25414, norovirus GII/Hu/H G/20l4/GII.4/C0HK-NS- 29824, 34234, 38644 315

3365 VPI KM26807S 33B5 7775 12185, 16595, 21005, 25415, norovirus GII.4

29825, 34235, 38645

3366 VPI KJ7I0247 33BB 777B 12186, IB53B, 2I00B, 254IB, norovirus GII/Hu/ZA/20l2/GII.Pe_GII.4 Sydney

2982B, 34236, 38646 20l2/JohannBsburg98l4

3367 VPI KJ685405 3367 7777 12187, 16597, 21007, 25417, norovirus Hu/GII/BGIC0282/20ll/BGD

29827, 34237, 38647 3368 VPI KF42B7BB 33G8 7778 12188, IB598, 21008, 25418, norovirus Hu/GII.4/NIHICI3/20ll/USA

29828. 34238, 38B48

33B9 PI KF0B0DD9 33B9 7779 12189, IB59B, 21009, 25419, norovirus Hu/GII.4/NSWII4H/2DI2/AU

29829, 34239, 38649

3370 VPI KF05999B 3370 7780 12190, IBBOO, 21010, 25420, norovirus Hu/GII.4/ACTD675/20l2/AU

29830, 34240, 38B50

3371 VPI HF952I30 3371 7781 12191. 16601. 21011, 25421, norovirus Hu/GII.4/C000079l8/20ll/UK

29831, 34241, 38651

3372 VPI KC409302 3372 7782 12192. IBB02, 21012, 25422, norovirus Hu/GII/20477/20IO/VNM

29832, 34242, 38B52

3373 VPI JX45B908 3373 7783 12193, IBB03, 21013, 25423, norovirus

29833, 34243, 38653 Hu/GII.4/Sydn _B y/NSW05l4/20l2/AU

3374 VPI JX445IBB 3374 7784 12194. IBB04, 21014, 25424, norovirus Hu/GII.4/AlbertaEI204/20IO/CA

29834. 34244, 38B54

3375 PI HQG93090 3375 7785 12195, IBB05. 2IDI5, 25425, norovirus Hu/GII.4 TH-S597/THA/2006

29835, 34245, 38655

337B VPI JN400BII 337B 778B 12196. IBBOB, 21016. 25426, norovirus Hu/GII-4/CGMHI3/2007/TW

29836, 34246, 38656

3377 VPI JN400B0B 3377 7787 12197, I6B07, 21017, 25427, norovirus Hu/GII-4/CGMHII/2006/TW

29837, 34247, 38B57

3378 VPI JQBI35I7 3378 7788 12198, IBB08, 21018, 25428, norovirus Hu/GII.4/WA2IOZ/2007/AU

29838, 34248, 38B58

3373 VPI JQ478409 3379 7789 12199, IBBQ9. 21019, 25429, norovirus Hu/GII.4/Minerva/200G/USA

29839, 34249, 38B59

3380 VPI GQ85B4B0 3380 77B0 12200, 16610, 21020, 25430, norovirus Hu/GII.4/Beijing/55l84/2008/CHN

29840, 34250, 38660

3381 VPI GQ856449 3381 7791 12201, I6BII, 21021, 25431, norovirus Hu/GII.4/Beijing/54l25/2007/CHN

29841, 34251, 38661

3382 VPI EU92I344 3382 7792 12202, 16612. 21022, 25432, norovirus Hu/Pune/PCI5/200G/lndia

29842. 34252. 38662

3383 VPI AB54I290 3383 7793 12203, 16613. 21023, 25433. norovirus Hu/GII-4/Miyazaki2/2007/JP

29843. 34253, 38663

3384 VPI GQ845322 3384 7794 12204, 16614, 21024, 25434, norovirus Hu/GII.4/VIC3B63/2007/AU

29844, 34254, 38664 3385 VPI AB22092I 3385 7795 12205, 16615. 21025, 25435, naravirus Hu/Chiba/04-l050/2005/JP

29845, 34255, 38665

3386 VPt KX5I422I 3386 7796 12206, 16616, 21026, 25436, norovirus GII.4

29846, 34256, 38666

3387 VPI KY48627I 3387 7797 12207. 16617, 2ID27, 25437, norovirus Gil

29847, 34257, 38667

3388 VPI P784602 3388 7798 12208, 16618. 21028, 25438, norovirus GII/Hu/ZAF/20ll/GII.P4JII.4/

29848, 34258, 38668 JohannBsburg/7028

3389 VPI KX37I604 3389 7799 12209, I66IB, 21029, 25439, norovirus GII.4

29849, 34259, 38G69

339D VPI X354079 3390 78D0 12210, 16620, 21030, 25440, norovirus GII.4

29850, 34260, 38670

3391 VPI X354028 3391 7801 12211, IB62I, 21031, 25441, norovirus GII.4

29851, 34261, 38671

3392 VP! X353983 3392 7802 12212, 16622, 21032, 25442, norovirus GII.4

29852, 34262, 38672

3393 VPI A89725II 3393 7803 12213. 16623. 21033, 25443, norovirus Hu/GII.4/Akital/20l2/JP

29853.34263.38673

3394 VPI AB972478 3304 7804 12214, 16624, 21034, 25444, norovirus Hu/GII.4/Fukui3/20l2/JP

29854, 34264.38674

3395 VPI KT780382 3395 7805 12215. 16625. 21035, 25445, norovirus Hu/GII.4/C0H -NS-555/HKG/2DI5

29855, 34265, 38675

3396 VPI KT033905 3396 7806 12216, 16626. 21036, 25446. norovirus Hu/Gll.4/SPHCII83/20I2/CHN

29856, 34266, 38676

3397 VPI KR904207 3397 7807 12217. 16627. 21037. 25447, norovirus Gil

29857, 34267.38677

3398 VPI KJ678I5I 3398 7808 12218, 16628, 21038. 25448, norovirus Hu/GII.4/Beijing/PK0PH-07- 29858, 34268, 38678 02/inpatient/20l3/CHN

3399 VPI KJG78I43 3399 7809 12219, 16629, 21039, 25449. norovirus Hu/GIU/Beijing/PKUPH-05- 29859, 34269.38679 OI/inpatient/2013/CHN

3400 VPI KP698927 3400 7810 12220, 16630. 21040, 25450, norovirus GII.4

29860, 34270, 38680

3401 VPI LC005730 3401 7811 12221. 16631, 21041, 25451, norovirus GII/Hu/JP/20l3/GII.4/yl2-V849-2

29861, 34271, 38681 3402 VPI LC0057I4 3402 78I2 I2222, IBB32, 2I042. 25452, narovirus GII/Hu/JP/2011/GiL4/y!0-V5ZB-B

298B2. 34272, 38682

34D3 PI KP24IB0B 3403 78I3 I2223, I6G33, 2I043, 25453, naravirus GII.4

29863, 34273, 38683

34D4 VPI K 9S293S 3404 78I4 I2224, I6634, 2I044, 25454. narovirus GII/Hu/HKG/2DI4/GII.4/CUH -NS- 29864, 34274, 38684 345

34D5 VPI KM5I4058 3405 78I5 I2225, I6635, 2I045, 25455, nomvirus GII/Hu/HKG/2014/GII UHK-NS- 29865. 34275, 38685 312

3406 VPI KMI98580 34DB 78IB I2226. I6636, 2I046, 25456, naravirus Hu/Gll/I0223/20D9/VNM

2B866, 34276, 38686

3407 VPI KMI98537 3407 78I7 I2227, I6B37, 2I047, 25457, narovirus Hu/GII/f D137/20DB/VNM

29867, 34277, 38687

34D8 VPI KFI77450 3408 78I8 I2228, I6638, 2I048, 25458, narovirus Hu/GII.4/3450GI58/AUS/20l2

29868. 34278, 38688

3409 VPI KF0Q8243 3409 78I9 I2229. IB639, 2I049, 25459, naravirus Hu/Gil.4/ variant Sydney 2012/FRA

29869, 34279, 38689

34I0 VPI KF429782 34I0 7820 I2230, I6640, 2I050, 25460, norovirus Hu/Gll.4/NIHICI.3/20I0/0SA

29870, 34280, 38690

34II VPI KFOBOIOI 34II 782I I223I, I664I, 21051. 25461, norovipus Hu/GII.4/NSW7B7K/2DI2/AU

29871, 34281, 38691

34I2 VPI KF0B003B 34I2 7822 12232, IB642, 21052, 25462, norovirus Hu/GII.4/NSW74GS/ZDI2/AU

29872, 34282, 38692

34I3 VPI KF0B007I 34I3 7823 12233, 16643, 21053, 254B3, naravirus Hu/GII.4/NSW59BJ/20l2/AU

29873, 34283. 38693

34I4 VPI KFDBDD5B 34I4 7824 12234, 16644, 21054, 25464, norovirus Hu/GII.4/NSW483T/ZDIZ/AU

29874, 34284, 38694

34I5 VPI JX43983B 34I5 7825 12235, 16645. 21055, 254B5, norovirus HU/GII/SGDUII835/K0R/20II

29875, 34285, 38695

34IB VPI HF052I2B 34IB 782B 12236, 1664B, 21056, 25466, norovirus Hu/GII.4/C000079l6/20ll/UK

29876. 34286, 38696

34I7 VPI KC40B273 34I7 7827 12237, 16647, 21057. 25467. norovirus Hu/GII/20IB6/20D9/VNM

29877, 34287, 38697

34I8 VPI KC409242 34I8 7828 12238, 16648, 21058, 25468, naravirus Hu/Gll/I0406/20ID/VNM

29878, 34288, 38B98 3419 VPI JX445IB7 3419 7829 12233, IBB49, 21059, 254B9, narovirus Hu/Gll.4/AlbertaEI0B5/201i/CA

2B879, 3428B, 38B93

3420 VPI JX445I5B 342B 7830 12240, IBB50, 2I0B0, 25470, noravirus Hu/GII.4/AlbBrtaEI498/ZD0B/CA

29880, 342B0, 387D0

3421 VPI GQ85B458 3421 7831 12241, 16651, 21061, 25471, narovirus Hu/GII.4/Beijing/55IG2/2008/CHN

29881, 34291, 38701

3422 VPI AB54I299 3422 7832 12242, I6B52, 21062, 25472, noravirus Hu/GII-4/Miyazaki8/2008/JP

29882, 34292, 38702

3423 VPI AB54II95 3423 7833 12243, IBB53, 2I0B3, 25473, noravirus Hu/GII-4/2008a_ORF2-3/JP

29883, 34293, 38703

3424 VPI AB504322 3424 7834 12244, 16654, 21064, 25474, noravirus Hu/GII.4/Hirashima/l08/2007/JPN

2B884, 34294, 38704

3425 VPI EU87B8B2 3425 7835 12245, 16655, 21065, 25475, narovirus Hu/GGII.4/Cairol/2006/EGY

2B885, 34295, 387D5

3426 VPI EU87B8BI 342B 783B 12246, 16656, 21066, 2547B, noravirus Hu/GGII.4/0ijon-E2703/Z008/FRA

29886, 34296, 38706

3427 PI AB294792 3427 7837 12247, IB657. 21067, 25477, noravirus Hu/GII-4/ imitsu/QBII46/200B/JP

29887, 34297, 387D7

3428 VPI AB303932 3428 7838 12248, IB658, 21068, 25478, noravirus Hu/GGII.4/DenHaagOOI/Z003/NL

29888, 34298, 38708

3429 VPI LCI77BBD 3423 7833 12249, IB659, 2IBB3, 25479, narovirus GII.4

29889, 34299, 387D9

343D VPI KXB088B6 343D 7840 12250, IBB60, 21070, 25480, narovirus GII.4

2389B, 34300, 38710

3431 VPI KX37IB03 3431 7841 12251, 16661, 21071, 25481, noravirus GII.4

29891. 343BI, 38711

3432 VPI KX354D8B 3432 7842 12252, I6B62, 21072, 25482, noravirus GII.4

23832, 34302, 38712

3433 VPI X354080 3433 7843 12253, I6B63, 21073, 25483, noravirus GII.4

23833, 343B3, 38713

3434 VPI KX354D54 3434 7844 12254, IB664, 21074, 25484. noravirus GII.4

23834, 34304, 38714

3435 VPI KX354D4I 3435 7845 12255, I6BB5, 21075, 25485, narovirus GII.4

29895, 34305, 38715 343B VPI X354B29 343B 784B 12256, IBBBB, 2I07B, 2548B, norovirus GII.4

2989B, 343DB.387IB

3437 VPI KX353377 3437 7847 12257, IBBB7, 21077, 25487, norovirus GII.4

23837, 34307, 38717

3438 VPI X3533G5 3438 7848 12258, IBB68, 21078, 25488, norovirus GII.4

23838, 34308, 38718

3430 VPI U3III58 3439 7849 12253, IBBBB, 21079, 25489, norovirus Hu/GII.4/AlbErtaEI350/20l4/CA

29899, 34309.38719

344D PI AB3744D8 3440 7850 I22B0, IBB70, 21080, 25490, norovirus Hu/GII.4/T272/clade 200Gb

29900.34310.38720

3441 VPI K 3D422I 3441 7851 I22BI. 16671, 21081, 25491, norovirus Gil

29901, 34311, 38721

3442 VPI AB9337G5 3442 7852 12262, IG672, 21082. 25492. norovirus Hu/Gli.4/Aichi5/20ll/JP

23902, 34312, 38722

3443 VPI AB9337BI 3443 7853 12263, I6G73, 21083, 25493, norovirus Hu/GII.4/0saka4/20ll/JP

29903.34313, 38723

3444 VPI AB333748 3444 7854 12264, IG674. 2ID84. 25494, norovirus Hu/GII.4/EhimB5/20ll/JP

29904, 34314, 38724

3445 VPI EU32I38G 3445 7855 12265, IG675, 21085, 25495, norovirus GII/Hu/IN/2007/GII.P4_GII.4_

29905, 34315, 38725 DenHaag2006b/PunE-PC43

344G VPI P24432I 344G 785B 12266. IB676, 21086, 25496. norovirus Hu/Gll.4/PA59/20I2/ITA

29906, 34316, 38726

3447 VPI KPB98923 3447 7857 12267, IB677, 21087, 25497, norovirus GII.4

29907, 34317, 38727

3448 VPI KP24I3Q5 3448 7858 12268, IG678, 21088, 25498, norovirus GII.4

29908, 34318, 38728

3443 VPI KPI7E393 3443 7859 12269, 16G79, 21089, 25499, norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 29B09, 34319, 38729 341

3450 VPI KP09G330 3450 78B0 12270, 16G80. 21090, 25500, norovirus Hu/GII/HKG/20!4/GII.4/C0HK-NS- 29910. 34320, 38730 377

3451 VPI K 982953 3451 78GI 12271, 16681. 21091, 25501, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29911.34321, 38731 365

3452 VPI KM982936 3452 78B2 12272, 16682, 21092, 25502, norovirus GII/Hu/H G/2DI4/GII.4/CUH -NS- 29912, 34322, 38732 340 3453 VPI M5I4D73 3453 7863 12273, 16683, 21093. 25503, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29913, 34323, 38733 330

3454 PI KM2B808B 3454 7864 12274, 16684, 21094, 25504, norovirus GII.4

29914, 34324, 38734

3455 VPI MI98552 3455 7865 12275, 16685, 21095, 25505, norovirus Hu/GII/20154/2009/VN

29915, 34325, 38735

345B VPI KJ7I6358 3456 7866 12276, 16686, 21096, 25506, norovirus Hu/GII.4/Beijing

29916, 34326, 38736

3457 VPI KJ649702 3457 7867 12277, 16687, 21097, 25507, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 29917, 34327, 38737 244

3458 VPI KF429778 3458 7868 12278, 16688, 21098, 25508, norovirus Hu/GII.4/NIHICIB.I/2DI2/USA

29918, 34328, 38738

3459 VPI KF060II3 3459 7869 12279, 16689, 21099, 25509, norovirus Hu/GII.4/NSW868l/20l2/AU

29919, 34329, 38739

34GD VPI KFD6DID6 3460 7870 12280, 16690, 21100, 25510, norovirus Hu/GII.4/NSW82GF/2DII/AU

29920, 34330, 38740

34GI VPI KF060I00 3461 7871 12281, 16691, 21101, 25511, norovirus Hu/GII,4/NSW783R/20ll/AO

29921, 34331, 38741

34GZ VPI KF060069 3462 7872 12282, 16692, 21102, 25512, norovirus Hu/GII.4/NSW584J/20ll/AU

29922, 34332, 38742

3463 VPI KF060055 3463 7873 12283, 16693, 21103. 25513, norovirus Hu/GII.4/NSW4GBJ/20ll/AU

29923, 34333, 38743

34G4 VPI F0B0D28 3464 7874 12284, 16694, 21104, 25514, norovirus Hu/GII.4/NSW295G/20l2/AU

29924, 34334.38744

3465 VPI KF060022 3465 7875 12285, 16695, 21105, 25515, norovirus Hu/GII.4/NSW23l7/2DII/AU

29925, 34335, 38745

3466 VPI C5I7376 3466 7876 12286, 16696, 21106, 25516, norovirus Hu/GII- 29926, 34336, 38746 4/Taoyuan/CGMH6G/20l2/TW

3467 VPI KC5I7374 3467 7877 12287. 16697, 21107, 25517. norovirus Hu/GII- 29927, 34337. 38747 4/Taoyuan/CGMH64/20l2/TW

34G8 VPI KC4D93D8 3468 7878 12288. 16698, 21108. 25518, norovirus Hu/Gll/30II2/200B/VNM

29928, 34338, 38748

3469 VPI CI75393 3469 7879 I228B, 16699, 21109, 25519, norovirus Hu/Norwalk/20033/2009/VNM

29929, 34339, 38749 3470 VPI JX45eG23 347B 7880 12290. IB700, 21110. 25520, narovirus Hu/BII.4/SG40B5-08/2007/SB

2993D, 34340, 38750

3471 VPI JQ7B8I58 3471 7881 12291, 16701. 2IIII, 25521, narovirus Hu/GII.4/5M/USA/Z0D4

23331, 34341, 38751

3472 VPI JQ6I3566 3472 7882 I22B2, IB702, 21112, 25522, narovirus Hu/Bll.4/NSW567H/20I0/A0

29932, 34342, 38752

3473 VPI AB54I287 3473 7883 12293, 16703, 21113, 25523. narovirus Hu/GII-4/ iyazakil3/2008/JP

29933, 34343.38753

3474 VPI AB50432D 3474 7884 12294, IB704, 21114, 25524, narovirus Hu/GII.4/Hirashima/3l/2006/JPN

23334, 34344, 38754

3475 VPI KU683733 3475 7885 12235, 16705. 21115, 25525. noravirus GII.4

23335, 34345, 38755

3476 VPI X354I46 347B 788B 12296, I670B, 2IIIB, 25526, narovirus GII.4

29936, 34346, 38756

3477 VPI KX354D75 3477 7887 12297, 16707, 21117, 25527, narovirus GII.4

29937, 34347, 38757

3478 VPI KX354072 3478 7888 12298, 16708, 21118, 25528, narovirus GII.4

23938.34348.38758

3479 VPI KX354060 3473 7883 12299, I670S, 21113, 25523, narovirus GII.4

29939.34349, 38759

348D VPI KX353959 348B 7890 12300, 16710, 21120, 25530. narovirus GII.4

23340.34350, 387BD

3481 VPI KX353954 3481 7891 12301, 16711, 21121, 25531, noravirus GII.4

23341, 34351, 387BI

3482 VPI ABB72529 3482 7892 12302, 16712, 21122, 25532, narovirus Hu/GII.4/Hirashima2/20l2/JP

23342, 34352, 38762

3483 VPI AB3725D4 3483 7893 12303, 16713, 21123, 25533, narovirus Hu/GII.4/GII4-NGI343/20ll/JP

23343.34353.38763

3484 VPI AB9725D3 3484 7894 12304, 16714, 21124, 25534, narovirus Hu/GII.4/GII4-NGI3l5/2DII/JP

23344.34354, 38764

3485 VPI KP244322 3485 7895 12305. 16715, 21125, 25535, noravirus Hu/Gll.4/PA39/20I2/ITA

23345, 34355, 38765

3486 PI LC0I87BB 348B 789B 12306, 16716, 21126, 2553B, noravirus Hu/Gll.4/Aichi368-I4/20I4

23346, 3435B, 38766 3487 VPI KP096345 3487 7897 12307. 16717. 21127. 25537. norovirus Hu/GII/H G/20l4/GII.4/CUH -NS- 29947, 34357.38767 399

3488 VPI KM982939 3488 7898 12308, 16718, 21128, 25538. norovirus GII/Hu/HKG/20l4/GII.4/C0HK-NS- 29948.34358, 38768 347

3488 VPI KMI98588 3489 7899 I23D9, 16719, 21129, 25539, norovirus Hu/GII/10037/2000/VNM

29949, 34359, 38769

3490 VPI K 198544 3490 7900 12310, 16720, 21130. 25540, norovirus Hu/GII/C24l8/20IO/VNM

29950, 34360, 38770

3491 VPI MI98522 3491 7901 12311. IB72I. 21131, 25541, norovirus Hu/GII/20150/2009/VNM

29951.34361, 38771

3492 VPI MI98508 3492 7902 12312, 16722, 21132, 25542, norovirus Hu/GII/2Q066/2009/VNM

29952, 34362, 38772

3493 VPI KJ7IB3B7 3493 7903 12313. 16723, 21133. 25543, norovirus Hu/GII.4/Beijing

29953, 34363, 38773

3494 VPI KFI77440 3494 7904 12314. 16724, 21134, 25544, norovirus Hu/GII.4/32973745/AUS/20l2

29954, 34364, 38774

3495 VPI KF0B0117 3495 7905 12315, 16725, 21135, 25545, norovirus Hu/GII.4/NSW9l7l/20l2/AU

29955, 34365, 38775

3496 VPI KF0G0I04 3496 7906 12316, 16726, 21136. 25546. norovirus Hu/GII.4/NSW820J/20ll/AO

29956.34366, 38776

3497 VPI KF0B0095 3497 7907 12317, 16727, 21137, 25547, norovirus Hu/GII,4/NSW7l88/20l2/AU

29957, 34367, 38777

3498 VPI KF0B0084 3498 7908 12318, 16728, 21138, 25548, norovirus Hu/GII,4/NSW6BDC/20ll/AO

29958, 34368, 38778

3499 VPI F0B0082 3499 7909 12319. 16729, 21139, 25549, norovirus Hu/GII.4/NSWG3BQ/20l2/AU

29959, 34369, 38779

3500 VPI KF060079 3500 7910 12320, 16730, 21140, 25550, norovirus Hu/GII,4/NSW623B/20ll/AU

29960, 34370, 38780

35DI VPI F0B0058 3501 7911 12321, 16731, 21141, 25551, norovirus Hu/GII.4/NSW5047/20ll/AU

29961, 34371, 38781

3502 VPI KF060039 3502 7912 12322, 16732, 21142, 25552, norovirus Hu/GII.4/NSW3522/2OI2/A0

29962, 34372, 38782

3503 VPI KF060030 3503 7913 12323, 16733, 21143, 25553, norovirus

29963, 34373, 38783 Hu/GIL4/Sutherland/NSW3IIA/20l2/AU 3504 VPI JX439829 3504 7014 12324, 16734, 21144, 25554, narovirus Hu/GII/SBaull034/KO /20IO

29964, 34374, 38784

3505 VPI KC409282 3505 7915 12325, 16735, 21145, 25555, noravirus Hu/GII/20230/200B/VNM

29965, 34375, 38785

350B VPI KC409259 350G 7916 12326, 16736, 21146, 25556, noravirus Hu/Gll/20I62/20D9/VNM

29966. 34376, 38786

3507 VPI JX450B5e 3507 7917 12327, IB737, 21147, 25557, noravirus Hu/GII.4/SG40IO-OI/20ll/SG

299B7, 34377, 38787

3508 VPI JX459B58 3508 7918 12328, IB738, 21148, 25558, noravirus Hu/GII.4/SG4009-DI/20ll/SG

23968, 34378, 38788

3509 VPI JX459595 3509 7919 I232B, 16733, 21149, 25559, noravirus Hu/Gll.4/SG40I3-09/2004/SG

23969, 34379, 38789

3510 VPI JQBI35B0 3510 7920 12330, 16740, 21150, 25560, noravirus Hu/GII.4/NSW445E/20IO/AU

29970, 34380, 38790

3511 VPI J0BI3545 3511 7921 12331, 16741. 21151, 255BI, noravirus Hu/GII.4/NSW673P/20IO/AU

29971, 34381, 38791

3512 VPI AB54I288 3512 7922 12332, 16742, 21152, 25562, narovirus Hu/GII-4/Miyazakil/2007/JP

29972, 34382, 38792

3513 VPI AB54I247 3513 7923 12333, 16743, 21153, 25563, noravirus Hu/GII-4/Fukui4/2007/JP

23973, 34383, 38793

3514 VPI E0839585 3514 7924 12334, 16744, 21154, 255B4, narovirus Hu/GII/B _E ijing/274/20 D5/CHN

29974, 34384, 38794

3515 VPI AY58802I 3515 7925 12335, 16745, 21155, 25565, narovirus Hu/NLV/Oxford/BGSG/2003/O

29975, 34385, 38795

35IB VPI KX5I4I88 35IB 7926 I233B, IB746, 21156, 2556B, noravirus GII.4

2997B, 3438B, 3879B

3517 VPI KX354I0I 3517 7927 12337, IB747, 21157, 255B7, noravirus GII.4

29977, 34387, 38797

3518 VPI KX354023 3518 7928 12338. 16748, 21158, 25568, noravirus GII.4

29978, 34388, 38798

3519 VPI KX353B79 3513 7929 12339, 16743, 21153, 255B9, narovirus GII.4

29979, 34389, 38799

3520 VPI AB97249I 3520 7930 12340, I675D, 21160. 25570, noravirus Hu/GII.4/Sakai5/20l2/JP

29080, 34390, 38800 3521 VPI AB9724B9 3521 7931 12341, 16751, 2IIBI, 25571, norovirus Ho/BII.4/Aomori5/20l2/JP

20981, 34391, 38801

3522 VPI LCIDI8I9 3522 7932 12342. IB752, 2IIB2, 25572, norovirus GH/Hu/Jp/2DI2/GII.4/sl2DJ53

29982, 34392, 38802

3523 VPI KT202795 3523 7933 12343, IB753, 2IIB3, 25573, norovirus Gil

29983, 34393.38803

3524 VPI ABB33742 3524 7934 12344, IB754, 21164. 25574, norovirus Hu/GII.4/Nagano2/2009/JP

29984, 34394, 38804

3525 VPI AB933722 3525 7935 12345, IB755, 21165, 25575, norovirus Hu/GII.4/EhimE3/2DII/JP

23385, 34395, 38805

352B VPI KJ678I38 352B 793B I234B. IB75B, 21166. 25576, norovirus Hu/GII.4/Beijing/PKUPH-02- 29986, 34396, 38806 05/inpatient/20l3/CHN

3527 VPI P2443I7 3527 7937 12347, 16757, 21167, 25577, norovirus Hu/Gll.4/PR328/20I3/ITA

29987, 34397, 38807

3528 VPI PB98B25 3528 7938 12348, 16758, 21168, 25578, norovirus GII.4

29988.34398.38808

3529 VPI LCD05727 3529 7939 12349, 16759, 2IIB9, 25579, norovirus GII/Hu/JP/2DI2/GII.4/yl2-V78D-l

29989, 34399, 38809

3530 VPI LC0IBB03 3530 7940 12350, 16760, 21170, 25580, norovirus Hu/JP/20B4/GII.4/Sakai/0l- 29990.34400.38810 inpationt8-29d-2

3531 VPI LC0I659B 3531 7941 12351, 16761, 21171, 25581, norovirus Hu/JP/2DD4/GII.4/Sakai/DI- 29991, 34401.38811 inpatient6-2d

3532 VPI KP233587 3532 7942 12352. 16762, 21172, 25582, norovirus GII/Hu/H G/2DI4/GII.4/CUHK-NS- 29992, 34402, 38812 457

3533 VPI PI7B402 3533 7943 12353. IB7B3, 21173, 25583, norovirus Hu/GII/HKG/20l4/GII.4/CUH -NS- 23S93.344B3.38813 415

3534 VPI JIBB287 3534 7944 12354, IB764, 21174, 25584, norovirus

23394, 34404, 38814 GII/Hu/JP/20IO/GII.P4JII.4/Shimada/ASC9G

3535 VPI MIB848D 3535 7945 12355, IB765, 21175, 25585, norovirus Hu/GII/IOIIG/2009/VNM

29995, 34405, 38815

353B VPI J7IB357 353B 794B I235B, IB7B6, 21176. 2558B, norovirus Hu/GII.4/Beijing

29906.344B6, 388IB

3537 VPI J7IB354 3537 7347 12357, IB7B7, 21177, 25587, norovirus Hu/GII.4/Beijing

23397, 34407, 38817 3538 VPI JB854D3 3538 7948 12358, IB7B8, 21178. 25588, norovirus Hu/GII/8GIC0204/20ll/BGD

29998, 34408, 38818

3539 VPI KFDB0I08 3539 7949 12359, IB7B9, 21179, 25589, norovirus Hu/GII.4/NSW838l/20l2/AU

29999, 34409, 38819

354D VPI KF0BDDB9 354D 795D I23B0, IB77D, 21180, 25590, norovirus Hu/GII.4/NSW783l/20ll/AU

30000. 34410, 38820

3541 VPI FDBDDQ4 3541 7951 12361. 16771. 21181, 25591. norovirus Hu/GII.4/NSW078G/20l2/AU

30001, 34411, 38821

3542 VPI KFOBOOOG 3542 7952 12362, 16772, 21182, 25592, norovirus Hu/GII.4/NSW097K/20l2/AU

30002, 34412, 38822

3543 VPI KC5I737I 3543 7953 12363, 16773, 21183, 25593, norovirus HU/GII-4/NEW

30003, 34413, 38823 Taipei/CGMHBI/2012/TW

3544 VPI JX459B57 3544 7954 I23G4, IB774, 21184, 25594, norovirus Hu/Gll.4/SG4002-I2/20I0/SG

3D004, 34414, 38824

3545 VPI JX459G5B 3545 7955 12365, 16775, 21185, 25595, norovirus Hu/GII.4/SG4054-08/20IO/SG

30005, 34415, 38825

3S46 VPI JX445I52 354B 795B I23B6, 16776, 21186, 25596, norovirus Hu/GII.4/AlbertaEII3l/2004/CA

3000B, 344IB, 3882B

3547 VPI JDBI3553 3547 7957 I23G7, 16777, 21187, 25597, norovirus Hu/Gll.4/NSWI8BM/20I0/A0

30007. 34417, 38827

3548 VPI JQBI3521 3548 7958 12368, 16778, 21188, 25598, norovirus Hu/GII.4/NSW3IID/2008/AU

30008, 34418, 38828

3549 VPI HO005298 3549 7959 12369, 16779, 21189, 25599, norovirus Hu/ll.4/2849738/H /2009

30009, 34419, 38829

3550 VPI HQ0D529B 3550 79B0 12370, 16780, 21190, 25600, norovirus Hu/ll.4/285B357/HK/2009

30010, 34420, 38830

3551 VPI HM802555 3551 79BI 12371, 16781, 21191, 25B0I, norovirus Hu/GII.4/Hong

30011, 34421, 38831 Kong/C0050l30/2005/CHN

3552 VPI GQ24680I 3552 79B2 12372, 16782, 21192, 25602, norovirus Hu/GGII.4/Dijon/E4032/2009/FRA

30012, 34422, 38832

3553 VPI AB5D43D8 3553 79B3 12373, 16783, 21193. 25603. norovirus Hu/GII.4/Hiroshima/44/2004/JPN

30013, 34423, 38833

3554 VPI DQ3G9797 3554 79B4 12374, 16784, 21194, 25604, norovirus Hu/Guangzhou/NVgzOI/CHN

30014, 34424, 38834 3555 VPI LCI77BBI 3555 7965 12375, IB785, 21105. 25B05, noravirus GII.4

30015, 34425, 38835

355B VPI LCI754BB 355B 79B6 12376, IB78B, 21196. 25606, norovirus Hu/GII/JP/20l6/GII,PIB_GII.4_

30016, 34426, 38836 Sydney20l2/Kawasakil94

3557 VPI KX354I37 3557 79B7 12377, 16787. 21197. 25B07, noravirus GII.4

30017, 34427, 38837

3558 VPI KX35403B 3558 7968 12378, 16788, 21198, 25608, narovirus GII.4

30018, 34428, 38838

355B VPI X3540II 3559 7969 12379, 16789, 21199, 25609, norovirus GII.4

30019, 34429, 38839

35GD VPI LCI53IZ2 35BD 7070 12380, 16790, 21200, 25610, noravirus GII/Hu/JP/2016/GII.PI6_GII.4_

30020, 34430, 38840 Sydney20l2/0CI6023

35BI VPI K I3I777 35BI 7971 12381, 16791. 21201, 25611, norovirus GII/Hu/IN/20ll/GII.P4_GII.4_

30021, 34431, 38841 New0rlBans20Q9/Pune-l!2370

35BZ VPI AB9337B4 35B2 7972 12382. 16792, 21202, 25GI2. norovirus Hu/GII.4/Dsakal/20ll/JP

30022, 34432, 38842

35B3 VPI LCDIBBOQ 3563 7973 12383, 16793, 21203, 25613. norovirus Hu/JP/2004/GII.4/Sakai/OI- 30023, 34433.38843 inpatient6-26d

35B4 VPI KJ433B7D 35B4 7974 12384. IB794, 21204, 25BI4, norovirus I3-AV-I-I0/20I2/GII.4

30024, 34434, 38844

35B5 VPI KPI7B395 35B5 7975 12385. 16795, 2I2D5, 25615, noravirus Hu/GII/HKG/2DI4/GII.4/CUH -NS- 30025, 34435, 38845 352

35BB VPI KMB82947 35BB 7976 I238B, IB79B, 21206, 25616, noravirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 30026, 34436, 38846 358

35B7 VPI KJB854I4 35B7 7977 12387, 16797, 21207, 25617. norovirus Hu/GII/BGIC0004/20IO/BGD

30D27, 34437.38847

35B8 VPI F0B0093 35B8 7978 12388. 16798, 21208, 25618, norovirus Hu/GII.4/NSW7H7/20l2/AU

30028, 34438, 38848

35BB VPI C45B070 35B9 7979 12389, 16799, 21209, 25GI9, norovirus

30020, 34439, 38849 Hu/GII.4/VPII72/Shanghai/20l2/CHN

357D VPI C409299 3570 7980 12390, 16800, 21210, 25G20, norovirus Hu/GII/20457/2010/VNM

30030, 34440, 38850

3571 VPI JX984947 3571 7981 12391, 16801, 21211, 25621, noravirus Hu/GII.4/GZ20IO- 30031, 34441, 38851 L32/Guangzhou/CHN/20IO 3572 VPI KCI75385 3572 7982 I2392. IG8B2, 2I2I2. 25G22, norovirus Hu/Norwalk/10368/2010/VNM

3B032, 34442, 38852

3573 VPI JQ6I35G3 3573 7983 I23B3. IB8G3, 2I2I3, 25G23, norovirus Hu/GII.4/NSW3039/20IO/AU

30033, 34443, 38853

3574 VPI JQGI3558 3574 7984 I2394, IG8D4, 2I2I4, 25G24, narovirus Hu/GII.4/NSW68ll/20l0/A0

3DD34, 34444, 38854

3575 VPI GG85G45I 3575 7985 I2395, IG8D5, 2I2I5, 25625, no ^p Dvirus Hu/GII.4/Beijing/54B5l/2DD7/CHN

3GD35, 34445, 38855

3576 VPI D04I9908 357B 798G I2396, I68D6, 2I2IG, 25626, norovirus Hu/Beijing/CR2932/2004/CHN

30036, 34446, 38856

3577 VPI KX5I4354 3577 7987 I2397, IB807. 2I2I7, 25627, narovirus GII.4

30037, 34447, 38857

3578 VPI X354062 3578 7988 I2398, I6808, 2I2I8, 25628, narovirus GII.4

30038, 34448, 38858

3578 VPI ABB72532 3579 7989 I2399, I6809, 21213, 25629, narovirus Hu/GII.4/Shimane2/20l2/JP

30039, 34449, 38859

358D VPI KT2D279G 358D 799D 12400, 16810, 21220, 25630, norovirus Gil

30040, 34450, 388G0

358I VPI AB93375I 358I 799I 12401, 16811. 21221, 25631, narovirus Hu/GII.4/Hiroshima5/2009/JP

30041, 34451, 38861

3582 VPI K 5I4078 3582 7992 12402, 16812, 21222, 25632, norovirus GII/Hu/HKG/20l4/GII.4/CUHK-NS- 30042, 34452, 38862 335

3583 VPI MIB85B9 3583 7993 12403, 16813. 21223, 25633, norovirus Hu/GII/10235/2009/VNM

30043, 34453, 38863

3584 VPI KF768522 3584 7994 12404, 16814, 21224, 25634, norovirus

30044, 34454, 38864 Hu/Gll.4/P63/20I2/Gothenburg/Sweden

3585 VPI KFBG0I2B 3585 7995 12405, 16815, 21225, 25635, norovirus Hu/GII.4/NSW959S/20l2/AU

30045, 34455, 38865

358B VPI KFBG0IB2 358B 799G 12406, 16816, 21226, 25636, norovirus Hu/GII.4/NSW8IIC/20l2/AU

30046, 34456, 388G6

3587 VPI FDBDD88 3587 7997 12407, 16817, 21227. 25G37, norovirus Hu/GII.4/NSWG79Q/20ll/AU

30047, 34457, 38867

3588 VPI KFDGDD25 3588 7908 12408, 16818, 21228, 25638, norovirus Hu/GII.4/NSW270F/20l2/AU

30048, 34458, 38868 3589 VPI C5I7378 3589 7999 12409. 16819. 21229, 25B39. norovirus Hu/GII-4/New

30049, 34459, 38869 Tai _P Bi/CGMHG8/20l2/TW

359D VP! JX45BB4D 359D 8BDB 12410, IB820, 21230, 25B40. norovirus Hu/GI!4/SG4070-07/2009/SG

30050, 344B0, 38870

35BI VPI JQBI35I2 3591 8DDI 12411, 1682! 21231, 25B4I, norovirus Hu/GI!4/WAI45Y/2007/AU

3005! 344G! 38871

3592 PI HQDD5299 3592 8D02 12412, 16822, 21232, 25642. norovirus Hu/I!4/220I480/ /20I0

30052, 344B2, 38872

3593 PI AB54I3I2 3593 8003 12413, IB823, 21233, 25B43, norovirus Hu/GII-4/Niigata2/2008/JP

30053, 34463, 38873

3594 VPI AB54I275 3594 8004 12414, IB824, 21234, 25644, norovirus Hu/GII-4/lwate5/2007/JP

30054, 344B4, 38874

3595 VPI AB30333D 3595 8005 12415, IB825, 21235, 25645, norovirus Hu/BGII.4/HeerlBnDD3/2DD3/NL

30055, 34465, 38875

3596 VPI AY485B42 359B 800B 12416, IB826, 2I23B, 25B4B, human calicivirus

30056, 34466, 38876 NLV/GII/LangenlOBI/2002/DE

3597 VPI KX5I4343 3597 8007 12417, 16827, 21237, 25B47, norovirus GII.4

30057, 34467, 38877

3598 VPI X5I4274 3598 8008 12418, 16828, 21238, 25B48, norovirus GII.4

30058.34468, 38878

3599 VPI KX5I4I75 3599 8009 12419, 16829, 21239, 25B49, norovirus GII.4

30059, 3446B, 38879

3BDD VPI KX354093 3B00 8010 12420, 16830, 21240, 25B50, norovirus GII.4

300B0, 34470, 38880

3601 VPI KX354003 3B0I 8011 1242! 1683! 2124! 2565! norovirus GII.4

3006! 3447! 38881

36D2 VPI K I3I778 3B02 8DI2 12422, 16832, 21242, 25652, norovirus GII/Hu/IN/20ll/GI!P4JI!4_

30062, 34472, 38882 New0rleans2009/PunB-IIG686

36D3 VPI AB9724B8 3B03 8013 12423, 16833, 21243, 25653, norovirus Hu/GI!4/Aomori3/20l2/JP

30063, 34473, 38883

3BD4 VPI KR9D4222 3B04 8014 12424, 16834, 21244, 25654, norovirus Gil

30064, 34474, 38884

3BD5 VPI P244320 3B05 8015 12425, 16835, 21245, 25655. norovirus Hu/GI!4/PA33D/20ll/ITA

30065, 34475.38885 3606 VPI KP2443I5 3606 8016 12426, 16836. 21246, 25656, norovirus Hu/GII.4/PR784l/20ll/ITA

30066, 34476, 38886

3607 PI KP2443I4 3607 8017 12427, 16837, 21247, 25657. norovirus HU/GII.4/P I147I/20II/ITA

30067, 34477, 38887

3608 VPI KM268078 3608 8018 12428. 16838, 21248, 25658, norovirus GII.4

30068, 34478, 38888

3609 VPI KM19S555 3609 8019 12429, 16839, 21249, 25650, norovirus Hu/GII/C2035/20IO/VNM

30069, 34479, 38889

3610 PI F06DII5 3BI0 8020 12430, 16840, 21250, 25660, norovirus Hu/GII.4/NSW906P/20l2/AU

30070, 34480, 3889D

3611 VPI KF0600I8 3611 8021 12431, 16841, 21251, 25661. norovirus Hu/GII.4/NSW2024/20l2/AU

30071. 34481. 38891

3612 VPI KC5I7365 3612 8022 12432. 16842. 21252. 25662, norovirus Hu/GII- 30072, 34482, 38892 4/Taoyuau/CGMH55/20l2/TW

3613 VPI KC5I7360 3613 8023 12433, 16843, 21253, 25663, norovirus HU/GII-4/NEW

30073. 34483, 38893 Tai _P Ei/CGMH50/20ll/TW

3614 VPI JX846928 3614 8024 12434, 16844. 21254, 25664, norovirus Hu/GII.4/NIHIC9/20ll/USA

30074, 34484, 38894

3615 VPI JX459904 3BI5 8025 12435, 16845, 21255, 25665, norovirus

30075, 34485, 38895 Hu/GII.4/Doonside/NSW536l/20ll/AU

3616 VPI JX459B49 3616 8026 12436, 16846, 21256, 25666, norovirus Hu/GII.4/SG406l-IO/2009/SG

30076, 34486, 38896

3617 VPI JX459643 3617 8027 12437. 16847, 21257, 25667, norovirus Hu/GII,4/SG4044-09/2009/SG

30077, 34487, 38897

3618 VPI JX459602 3618 8028 12438, 16848, 21258, 25668, norovirus Hu/GII.4/SG4009-0B/2006/SG

30078, 34488, 38898

3619 VPI LCI77655 3619 8029 12439, 16840, 21259, 25669. norovirus GII.4

30079. 3448B. 38899

3620 VPI KP784698 3620 8030 12440, 16850, 21260, 25670, norovirus

30080, 34490, 38900 Gll/Hu/ZAF/20I2/GII.P4_GII.4/ Johannesburg/

BW

3621 VPI KX354I04 3621 8031 12441, 16851, 21261, 25671, norovirus GII.4

30081, 34491, 38901

3622 VPI KR9042II 3622 8032 12442. 16852. 21262, 25672, norovirus Gil

30082. 34492, 38902 3623 VPI ABB33743 3B23 8033 12443. 16853, 21263, 25673, norovirus Hu/GII.4/Nagana4/2008/JP

30083, 34493, 38903

3B24 VPI LN854572 3B24 8D34 12444, 16854, 21264, 25674, naravirus BH/Hu/NL 20I2/Bll.4/Nijmegen02

30084, 34494, 38904

3B25 VPI P2443i 3B25 8035 12445, 16855. 21265, 25675, norovirus Hu/GII.4/PA278/20ll/ITA

30085, 34495, 38905

3B2B VPI KF768470 3B2B 8036 12446, 16856, 21266, 25676, norovirus

30086, 34436, 38906 Hu/GII.4/P2/20l2/GothBnburg/SwEd _E n

3B27 VPI KC45B073 3B27 8037 12447, 16857, 21267, 25677, norovirus

30087, 34497, 38907 Hu/BII.4/VPI45l/Shanghai/2DIZ/CHN

3628 VPI C45B072 3B28 8038 12448, 16858, 21268, 25678, norovirus

30088, 34498, 38908 Hu/GII.4/VPI28l/Shanghai/20l2/CHN

3B2B VPI JX45BG22 3B29 8039 12449. 16859, 21269. 25679, norovirus Hu/GII.4/SG4052-08/2007/SG

30089, 34499, 38909

3B3D VPI KX5I4290 3B3D 8040 12450, 16860, 21270, 25B80, norovirus GII.4

30090, 34500, 38910

3B3I VPI KP784695 3B3I 8041 12451. 16861, 21271, 25681, norovirus

30091, 34501.38911 GII/Hu/ZAF/20l2/GII.P4_GII.4/Em _P angEni/9G

93

3B32 VPI XB088B5 3632 8042 12452. 16862, 21272, 25682, norovirus GII.4

30092, 34502, 38912

3B33 VPI AB972500 3B33 8043 12453. 168G3, 21273, 25B83, norovirus Hu/GII.4/GII4-HK02/20ll/JP

30093, 34503, 38913

3B34 VPI KT033902 3B34 8044 12454, IB864, 21274, 25684. norovirus Hu/Gll.4/SPHC2048/20I2/CHN

30094, 34504, 38914

3B35 VPI 9D422Q 3B35 8045 12455, 16865, 21275, 25B85, norovirus Gil

30095, 34505, 38915

3B3B VPI LN854566 3B36 8046 12456, 16866, 21276, 25686, norovirus Gll/Hu/NL/20I4/Gll.4/Groningen0l

30096, 34506, 38916

3B37 VPI P2443I3 3637 8047 12457, 16867, 21277, 25687. norovirus Hu/GII,4/PRG876/20IO/ITA

30097, 34507, 38917

3638 VPI KP0BB342 3638 8048 12458, IB868, 21278, 25688. norovirus Hu/GII/HKG/20l4/GII.4/CUHK-NS- 30098, 34508, 38918 396

3B33 VPI KM5I4DG7 3636 8049 12459, 16869, 21279, 25689. norovirus GII/Hu/H G ZOI4/GII.4/CUH -NS- 30099, 34509, 38919 322 3640 VPI KFQ6Q04B 3640 8050 12460, 16870. 21280, 25690, norovirus Hu/GII.4/NSW43ID/20ll/AU

30100, 34510, 38820

3G4I VPI KF059998 3641 8051 12461, 16871, 21281, 25691, norovirus Hu/GII.4/NSWDDBG/ZOI2/AU

30101, 34511, 38921

3G42 VPi JX439833 3642 8052 12462, 16872, 21282, 25692, norovirus HU/GII/SB _D UII40B/K0R/20I0

30ID2, 34512, 38922

3G43 VPI JQ6I3548 3643 8053 12463, 16873, 21283. 25693, norovirus Hu/GII.4/NSW0336/2DI0/A0

30103, 34513.38923

3G44 VPI JN5B5867 3644 8054 12464. 16874, 21284, 25694, norovirus HU/GII.4/NBW Orleans/2010/USA

30104, 34514.38B24

3G45 VPI A8G29944 3645 8055 12465, 16875, 21285, 25695, norovirus Hu/Tokyo/I0-I443/20IO/JPN

30105, 34515, 38925

3B4G VPI AB54II92 3646 8056 12466, 16876, 2I28B. 25696, norovirus Hu/GII-4/2007b_ORF2-3/JP

30106, 345IB, 38926

3647 VPI AB5Q43I4 3647 8057 IZ467, 16877. 21287, 25697, norovirus Hu/GII.4/HiroshimB/59/2005/JPN

30107, 34517, 38927

3G48 VPI KX5I4350 3648 8058 12468, 16878, 21288, 25698, norovirus GII.4

30108.34518, 38B28

3649 VPI KX514342 3649 8059 12469, 16879, 21289, 25699, norovirus GII.4

30109, 34519, 38929

3650 VPI KX5I4280 3650 8060 12470, 16880. 21290, 25700, nnrovirus GII.4

30110, 34520, 38930

3651 VPI LCI77654 3651 8061 12471, 16881. 21291, 25701, norovirus GII.4

30111.34521, 38931

3652 VPI KX354026 3652 8062 12472, 16882. 2IZ92, 25702, norovirus GII.4

30112, 34522, 38932

3653 VPI KR9042I8 3653 8063 12473, 16883, 21293, 25703, norovirus Gil

30113, 34523, 38933

3654 VPI KJ678I50 3654 8064 12474, 16884, 21294, 25704, norovirus Hu/GII.4/Beijing/P UPH-D7- 30114, 34524, 38934 OI/inpatiBnt/2013/CHN

3655 VPI KJ678I48 3655 8065 12475. 16885, 21295, 25705, norovirus Hu/GII.4/Beijing/PKUPH-D5- 30115, 34525, 38935 06/inpatiEnt/20l3/CHN

3656 VPI KP2443I6 3656 8066 12476, 16886, 21296, 25706, norovirus Hu/GII.4/PR9474/20ll/ITA

30116, 34526. 38936 3657 VPI KF06Q072 3657 8067 12477, 16887, 21297, 25707, norovirus Hu/GII.4/NSW59BM/20ll/AO

30117, 34527, 38937

3658 VPI JX439822 3658 8068 12478, 16888, 21298, 25708, norovirus Hu/GII/Seoull39l/K0R/20l0

30118, 34528, 38938

3659 VPI KC4639I0 3659 8069 12479, 16889, 21299, 25709, norovirus Hu/GII.4/Dhio/B84/USA

30110, 34529, 38939

3660 VPI JX45B65I 366D 8070 12480, 16890, 2I3D0, 257ID, norovirus Hu/GII.4/SG4075-l2/2009/SG

30120, 34530, 38940

3661 VPI AB54I3I4 3661 8071 12481, 16891, 21301, 25711, norovirus Hu/GII-4/Niigata3/2008/JP

30121, 34531, 38941

3662 VPI AB5D4323 3B62 8072 12482, 16892, 21302, 25712, norovirus Hu/Gll.4/Hiroshim_/I09/2007/JPN

30122, 34532, 38942

3663 VPI KX353963 3663 8073 12483, 16893, 21303, 25713, norovirus GII.4

30123, 34533, 38943

3664 VPI KR9042I3 3664 8074 12484, 16894, 21304, 25714, norovirus Gil

30124, 34534, 38944

3665 VPI AB933745 3665 8D75 12485, IB895, 21305, 25715, norovirus Hu/GII.4/Aichi3/20IO/JP

30125, 34535. 38945

366G PI PD9634I 3BBB 8076 12486, 16896, 2I3D6, 25716, norovirus Hu/GII/H G/2DI4/GII.4/CUH -NS- 30I2B, 34536, 38946 305

3667 VPI KMII429I 3B67 8077 12487, 16897, 21307, 25717, norovirus Hu/GII.4/SJTUHI/CHN/2DI4

30127, 34537, 38947

3668 VPI KF06DID5 3668 8078 12488, 16898. 21308, 25718, norovirus HU/GII.4/NSW824F/20I2/AU

30128, 34538, 38948

3669 VPI KF06008I 36B9 8079 12489, IB899, 21309, 25719, norovirus Hu/GII,4/NSW628T/20l2/AU

30129, 34539, 38949

367D VPI KFD59999 367D 8080 12490, 16900, 21310, 25720, norovirus Hu/GII.4/NSW0D7P/2DI2/AU

30130, 34540, 38950

3671 VPI JX644D36 3B7I 8081 12491, 16901, 21311, 25721, norovirus Hu/GII.4/N94/20ll/HuZhou

30131, 34541, 38951

3672 VPI JX459654 3672 8082 12492, 16902, 21312, 25722, norovirus Hu/GII,4/SG405l-08/20IO/SG

30132, 34542, 38952

3673 PI JN4DD62I 3673 8083 12493, 16903, 21313, 25723, norovirus Hu/GII-4/CGMH23/20IO/TW

30133, 34543, 38953 3B74 VPI AB54I2BD 3B74 8084 12494, 16904, 21314, 25724, norovirus Hu/GII-4/Hakkaidal/2007/JP

30134, 34544, 38954

3B75 VPI KX5I434I 3B75 8085 12495, 16905, 21315, 25725. norovirus GII.4

30135, 34545, 38955

3B7B VPI KX5I4253 3B7B 8086 12496, 16906, 21316, 25726, norovirus GII.4

30136, 34546, 38956

3B77 VPI X5I4I95 3B77 8087 12497, 16907, 21317, 25727, norovirus GII.4

30137, 34547, 38957

3B78 VPI KX3540IG 3B78 8088 12498, 16908, 21318, 25728, norovirus GII.4

30138, 34548, 38958

3B79 VPI KM245073 3679 8089 12499, 16909, 21319, 25729, norovirus 09-81- 30139, 34549, 38959 2/2009/GII.4/NEw0rleans/2009

3680 VPI LN8545G7 3680 8090 12500. 16910. 21320, 2573D, norovirus GII/Hu/NL/20l4/GII.4/GroningEn02

30140.34550, 38960

3B8I VPI JN4006I9 3681 8091 12501. 16911, 21321. 25731, norovirus Hu/GII-4/CGMH2l/20IO/TW

30141, 34551, 38961

3B82 VPI KFDBD052 3682 8092 I25D2, 16912, 21322. 25732, norovirus Hu/GII.4/NSW45l2/20l2/A0

30142.34552.38962

3B83 VPI KF0600I4 3683 8093 12503, 16913. 21323, 25733. norovirus Hu/GII.4/NSWI627/20l2/A0

30143, 34553, 38963

3684 VPI KC5I7375 3684 8094 12504. 16914, 21324, 25734, norovirus Hu/GII- 30144, 34554.38964 4/Taoyuan/CGMH65/2QI2/TW

3B85 VPI JX644039 3685 8095 12505, 16915. 21325. 25735, norovirus Hu/GII.4/NI0l/20ll/HuZhou

30145, 34555, 38965

3B8B VPI JX64403I 3686 8096 12506, 16916. 21326, 25736, norovirus Hu/GII.4/N76/20IO/HuZhou

30146.34556, 38966

3B87 VPI HMI9I773 3687 8097 12507, 16917, 21327, 25737, norovirus Hu/Il.4/220066I/HK/20I0

30147, 34557, 38967

3B88 VPI AB504309 3688 8098 12508. 16918, 21328, 25738, norovirus Hu/GII.4/Hiroshima/48/2004/JPN

30148.34558, 38968

3B89 VPI X5I42IB 3689 8099 12509. 16919, 21329, 25739, norovirus GII.4

30149, 34559, 38969

3690 VPI KX5I42I2 3690 8100 12510. I692D. 21330. 25740, norovirus GII.4

30150, 34560.38970 3691 VPI KX354I38 3691 8101 12511. 16921. 21331, 25741. nnrovirus GII.4

30151. 345BI.38971

3B9Z VPI AB933747 3B92 8102 12512. IB922, 21332, 25742, norovirus Hu/Gll.4/Dsaka5/2DD9/JP

30152, 345B2, 38972

3693 VPI KJ955493 3B93 8103 12513, IB923, 21333, 25743. nnrovirus

30153.345B3, 38973 JB031230049/Nanshan/0B/IZ/20l2/SZ/CHN

3694 VPI JB78I53 3694 8104 12514. IB924, 21334. 25744, norovirus Hu/GII.4/BBijing/PK0PH-O7- 3DI54, 34564.38974 04/inpatiBnt/20l3/CHN

3695 VPI C45607I 3695 8105 12515. 16925, 21335, 25745, nnrovirus

30155, 34565, 38975 Hu/GII.4/VPIZI4/Shanghai/20l2/CHN

3696 VPI CI75384 3696 8106 12516, 16926. 2I33B, 25746, nnrovirus Hu/Norwalk/10328/2010/VNM

30156, 345B6, 3897B

3697 VPI J06I356I 3697 8107 12517, IB927, 21337, 25747. norovirus Hu/GII.4/NSW234D/2DI0/A0

30157, 34567, 38977

3698 VPI J678I45 3698 8108 12518, 16928. 21338. 25748. norovirus Hu/GII.4/B-ijing/PKUPH-05- 30158, 34568, 38978 03/inpatient/20l3/CHN

3699 VPI KF060II6 3699 8109 12519, 16929, 21339, 25749, norovirus Hu/GII.4/NSW9l6G/20l2/AU

30159, 345B9, 38979

370D VPI KC5I7362 3700 8110 12520. IB930, 21340, 2575D, norovirus Hu/GII- 30160, 34570, 38980 4/Taoyuan/CGMH52/20l2/TW

37DI VPI JXB44038 3701 8111 12521, 16931, 21341, 25751, norovirus Hu/GII.4/NI00/20ll/HuZhou

30161, 34571, 38981

3702 VPI AB5043I3 3702 8112 12522, 16932, 21342, 25752, nnrovirus Hu/GII.4/Hiroshima/58/2D05/JPN

30IB2, 34572, 38982

3703 VPI KX5I436I 3703 8113 12523, IB933. 21343, 25753, norovirus GII.4

30163, 34573, 38983

3704 VPI KX5I433B 3704 8114 12524, 16934, 21344, 25754, norovirus GII.4

30IB4, 34574.38984

3705 VPI X5I4203 3705 8115 12525. 16935, 21345, 25755, norovirus GII.4

30165, 34575, 38985

3706 VPI KP784693 3706 8116 I252B, IB93B, 2I34B, 2575B, norovirus

30166.34576.38986 GII/Hu/ZAF/20ll/GII.P4_GII.4/EmpangEni/850

1

3707 VPI AB933734 37D7 8117 12527, 16937, 21347, 25757. norovirus Hu/GII.4/Aomori5/2009/JP

30167, 34577, 38987 3708 VPI FDB004I 3708 8118 12528, IB938, 21348, 25758, norovirus Hu/GII.4/NSW3B3M/2Q12/AU

30IB8, 34578, 38988

3709 VPI JX989074 3709 8119 12529, IB939, 21349, 25759, norovirus Hu/GII.4/GZ20IO- 30IB9, 34579, 38989 L87/Guangzhou/CHN/20II

3710 VPI JN4D0B24 3710 8120 12530, IB940, 21350, 257B0, norovirus Hu/GII-4/CGMH2B/20IO/TW

30170, 34580, 38990

3711 VPI E087B894 3711 8121 12531, 16941, 21351, 257BI, norovirus Hu/GGII.4/Dijon-EI50l/2006/FRA

30171, 34581, 38991

3712 VPI X5I4I73 3712 8122 12532, IB942. 21352, 257B2, norovirus GII.4

30172, 34582, 38992

3713 VPI KX353989 3713 8123 12533, IB943, 21353, 257B3, norovirus GII.4

30173, 34583, 38993

3714 VPI KX353962 3714 8124 12534, IB944, 21354, 257B4, norovirus GII.4

30174, 34584, 38994

3715 VPI AB9725I5 3715 8125 12535, IB945, 21355, 257B5, norovirus Hu/GII.4/lwate2/20l2/JP

30175, 34585, 38995

37IB VPI KT033904 37IB 8I2B I253B, IB94B, 2I35B, 257BB, norovirus Hu/Gll.4/SPHCII34/20I2/CHN

30I7B, 3458B, 3899B

3717 VPI KM982942 3717 8127 12537, IB947, 21357, 257B7, norovirus GII/Hu/HKG/2DI4/GII.4/CUH -NS- 3DI77, 34587, 38997 350

3718 VPI JB854I7 3718 8128 12538, IB948, 21358, 257B8, norovirus Hu/GII/BGIC0270/20ll/BG0

30178, 34588, 38998

3719 VPI C907392 3719 8129 12539, IB949, 21359, 25769. synthetic construct

30179, 34589, 38999

3720 VPI C5I7377 3720 8I3D 12540, IB950, 2I3B0, 25770, norovirus Hu/GII- 30180, 34590, 39000 4/Taoyuan/CG H67/20l2/TW

3721 VPI C5I7368 3721 8131 12541, IB95I, 21361, 25771, norovirus Hu/GII-4/New

30181, 34591, 39001 Taipei/CGMH58/20l2/TW

3722 VPI AB54I3I0 3722 8132 12542, 16952, 21362, 25772, norovirus Hu/GII-4/Niigatal/2D08/JP

30182, 34592, 39002

3723 VPI EF535854 3723 8133 12543, IB953, 2I3B3, 25773, norovirus Hu/Guangzhou/NV-VPI/2D06/China

30183, 34593, 39003

3724 VPI KX5I4368 3724 8134 12544, 16954, 21364, 25774, norovirus GII.4

30184, 34594, 39004 3725 VPI KX5I435I 3725 8135 12545, 16955, 21365. 25775, norovirus GII.4

30185, 34595, 39005

3726 VPI KC5I7372 3726 8136 12546, 16956, 21366, 25776, norovirus Hu/GII-4/New

30186, 34596, 39006 Taipei/CGMH62/20l2/TW

3727 VPI JN4006I3 3727 8137 12547, 16957, 21367, 25777, norovirus Hu/GII-4/CGMHI5/2007/TW

30187, 34597, 39007

3728 VPI X5I429I 3728 8138 12548, 16958, 21368, 25778, norovirus GII.4

30188, 34598, 39008

3729 VPI KX5I42I9 3729 8139 12549, 16959, 21369, 25779, norovirus GII.4

30189, 34599, 39009

3730 VPI AB933668 3730 8140 I255D, 16960, 21370, 25780, norovirus Hu/GII.4/0saka4/20l0/JP

30190, 34600, 39DI0

3731 VPI KJ678I49 3731 8141 12551, 16961, 21371. 25781. norovirus Hu/GII.4/Beijing/PKUPH-05- 30191, 34601.39011 07/inpatient/20l3/CHN

3732 VPI KP2443I8 3732 8142 12552, 16962, 21372, 25782, norovirus Hu/GII.4/PA288/20ll/ITA

30192, 34602, 39012

3733 VPI KX5I4362 3733 8143 12553, 16963, 21373, 25783. norovirus GII.4

30193, 34603, 39013

3734 VPI X5I4329 3734 8144 12554, 16964, 21374, 25784, norovirus GII.4

30194, 34604, 39014

3735 VPI KJ678I52 3735 8145 12555, 16965. 21375, 25785. norovirus Hu/GII.4/Beijmg/PKUPH-07- 30195, 34605, 39015 03/inpatient/20l3/CHN

3736 VPI KX5I4352 3736 8146 12556. 16966, 21376, 25786, norovirus GII.4

30196, 34606, 39016

3737 VPI KX5I4339 3737 8147 12557, 16967. 21377, 25787. norovirus GII.4

30197.34607, 39017

3738 VPI K 904238 3738 8148 12558, 16968, 21378, 25788, norovirus Gil

30198, 34608, 39018

3730 VPI KJ7I0245 3739 8149 12559, 16969, 21379, 25789, norovirus Gil

30199, 34609, 39019

3740 VPI KX5I4298 3740 8150 12560, 16970. 21380, 25790. norovirus GII.4

30200, 34610, 39020

3741 VPI KX5I4269 3741 8151 12561. 16971. 21381. 25791, norovirus GII.4

30201, 34611, 39021 3742 VPI X5I4I7B 3742 8I52 I2562, IB972, 2I382. 25792. noravirus GII.4

3B2B2, 346I2, 39022

3743 VPI X5I4289 3743 8I53 I2563. I6973, 2I383. 25793, norovirus GII.4

3D203. 346I3, 39D23

3744 VPI KX5I4288 3744 8I54 I25B4. I6974, 2I384, 25794. noravirus GII.4

302D4, 346I4, 39024

3745 VPI X5I4268 3745 8I55 I2565, I6975, 2I385, 25795. norovirus GII.4

302D5, 34GI5, 39025

3746 VPI JX459653 3746 8I56 I25B6, I6976, 2I38B, 25796, norovirus Hu/Gll.4/SG40I4-04/20IO/SG

30206. 346I6. 39D26

3747 VPI KX5I4359 3747 8I57 I2567. I6977, 2I387. 25797, norovirus GII.4

302D7, 346I7, 39027

3748 VPI KX5I4296 3748 8I58 I25G8, I6978. 2I388, 25798, norovirus GII.4

30208, 34618, 39028

3748 VPI X5I4284 3749 8I59 12569, 16979, 21389, 25799, norovirus GII.4

30209, 34619, 39029

375D VPI X5I4245 375D 8I6D 12570, 16980, 21390, 25800, norovirus GII.4

30210, 34620, 39030

375I VPI KX5I4327 375I 8I61 12571, 16981, 21391, 25801, norovirus GII.4

30211, 34621, 39031

3752 VPI KX5I43QI 3752 8162 12572, 16982, 21392, 25802, norovirus GII.4

30212, 34622, 39032

3753 VPI KX5I4299 3753 8I63 12573, 16983, 1393. 25803, norovirus GII.4

30213, 34623, 39033

3754 VPI X5I4277 3754 8I64 12574. 16984, 21394, 25804, norovirus GII.4

30214, 34624, 39034

3755 VPI KX5I42I3 3755 8I65 12575, 16985, 21395, 25805, norovirus GII.4

30215, 34625, 39035

3756 VPI KT033903 3756 8I66 12576, 16986. 21396, 25806, norovirus Hu/Gll.4/SPHC27I5/2DI2/CHN

30216, 34626. 39036

3757 VPI HM625866 3757 8I67 12577, 16987, 21397, 25807, norovirus HU/GII.4/PECS/HUN4322/20I0/H0N

30217, 34627, 39037

3758 VPI KX5I43I9 3758 8IB8 12578. 16988, 21398, 25808, norovirus GII.4

30218, 34628, 39038 3759 VPI X5I43II 3759 8IB9 12579. IB989, 21399. 25809. norovirus GII.4

30219, 34B29, 39039

3760 VPI KX5142BB 37B0 8170 12580, IB99D. 21400, 25810, norovirus GII.4

30220, 34B30.3904D

37BI VPI KX5I4235 37BI 8171 12581, 16991. 21401. 25811, norovirus GII.4

30221, 34631, 39041

37B2 VPI X354II5 37B2 8172 12582, 16992, 21402, 25812, norovirus GII.4

30222, 34B32, 39042

37B3 VPI M272334 37B3 8173 12583, IB993, 21403. 25813, norovirus Hu/GII.4/gg-l2-08-04/20l2/K

30223, 34B33.39043

37B4 VPI KX354IIB 37B4 8174 12584, 16994, 21404, 25814, norovirus GII.4

30224, 34B34, 39044

37B5 VPI KX5I4I72 37B5 8175 12585, 16935. 21405, 25815, norovirus GII.4

30225, 34635, 39045

37BB VPI X354II4 37BB 8I7B 12586, 16996, 21406, 258IB, norovirus GII.4

30226, 34636, 39046

37B7 VPI KX5I4295 37B7 8177 12587, 16997, 21407, 25817, norovirus GII.4

30227, 34637.39047

37B8 VPI KX5I4242 37B8 8178 12588, 16998, 21408, 25818. norovirus GII.4

30228, 34638, 39048

37B9 VPI X5I4224 37B9 8179 12589, 16999. 21409, 25819, norovirus GII.4

30229, 34639, 39049

3770 VPI X5I42B2 3770 8180 12590, 17000, 21410, 25820, norovirus GII.4

30230, 34640, 39050

3771 VPI KX354I39 3771 8181 12591, 17001, 21411, 25821, norovirus GII.4

30231, 34641.39051

3772 VPI KX5I42I5 3772 8182 12592. 17002, 21412, 25822, norovirus GII.4

30232, 34642, 39052

3773 VPI X5I43B7 3773 8183 12593, 17003, 21413, 25823, norovirus GII.4

30233, 34643, 39053

3774 VPI X5I4243 3774 8184 12594, 17004, 21414, 25824, norovirus GII.4

30234, 34644, 39054

3775 VPI X35399B 3775 8185 12595, 17005, 21415, 25825, norovirus GII.4

30235, 34645, 39055 377G VPI DQ078820 377B 8I8B I259B. I7D0B. 2I4IB. 2582B, norovirus Hu/BII.4/Sydney9l7J/020/AO

3023B, 34B4B. 3905B

3777 VPI AB933738 3777 8187 12597, 17007, 21417, 25827, norovirus Hu/GII.4/Niigata5/2009/JP

30237, 34B47. 39057

3778 VPI EU780734 3778 8188 12598, 17008, 21418, 25828, norovirus Hu/GGII.4/Valencia/2004/ES

30238, 34648. 39058

3779 VPI KP064096 3779 8189 12599, 17009, 21419, 25829, norovirus GI.3

30239, 34649, 39059

378D VPI C473548 3780 8190 12600, 17010, 21420, 25830, norovirus Hu/GI/HuzhouNIO/2008/CHN

30240, 3465D, 39060

3781 VPI ABB84B98 3781 8ISI 12601. 17011, 21421, 25831, norovirus Hu/GI/46-2/Tokyo/l977/JPN

30241, 34651, 390BI

3782 VPI AF538B79 3782 8192 I2B02, 17012. 21422, 25832, human calicivirus NLV/BoxEr/2001/OS

30242, 34652, 390B2

3783 VPI JQ743332 3783 8193 12603, 17013, 21423, 25833, norovirus Hu/GI.2/1999

30243, 34B53, 390G3

3784 VPI GB85B47B 3784 8194 12604, 17014. 21424, 25834, norovirus Hu/GII.4/Beijing/54IOB/2DD7/GHN

30244, 34B54. 39064

3785 VPI JNBD3244 3785 8195 12605, 17015. 21425. 25835, norovirus Hu/GI.3/S29/2008/Lilla

30245, 34655, 39065 Edet/Sweden

3786 VPI AB078335 378G 8I9B 12606, 17016, 21426, 2583B, Norwalk-like virus

3D24B, 34656, 39066

3787 VPI GU2997GI 3787 8197 12607, 17017, 21427, 25837, norovirus Hu/GI.8/200889032l/2008/US

30247, 34657. 39067

3788 VPI AJ277BIB 3788 8198 12608. 17018, 21428, 25838, human calicivirus HB/NLV/Whiterose/BB/UK

3D248, 34658, 39068

3789 VPI GQ85G4G2 3789 8199 12609, 17019, 21429, 25839, norovirus Hu/GII.4/Beijing/53G7l/20D7/CHN

30249, 34659. 39069

379D VPI AF4358Q7 379Q 8200 12610, 17020, 21430, 25840, human calicivirus NLV/C59/99

30250, 34660, 39070

3791 VPI KX396056 3791 8201 12611, 17021, 21431, 25841, primate norovirus

30251, 34661, 39071

3792 VPI ABI875I4 3792 8202 12612, 17022, 21432, 25842, norovirus Hu/GI/Otofuke/1979/JP

30252, 34662, 39072 3703 VPI L074I8 3793 8203 I2BI3, I7B23, 21433, 25843. Southampton virus

30253.34BB3, 39073

3794 VPI FJ5I5294 3794 8204 12614. 17024. 21434, 25844, norovirus Hu/GI.2/Leuven/2003/BEL

30254, 34BB4.33074

3795 VPI J790I98 3795 8205 12615, 17025. 21435, 25845, bat norovirus

3D255, 34665, 39075

3796 VPI KF3062I2 379B 820G 12616, I702B, 21436, 25846. norovirus Hu/Gl.2/Jingzhnu/20I340I/CHN

3025B, 346BB, 39076

3797 VPI 4GIBB4 3797 8207 12617. 17027, 21437, 25847, norovirus II-FJ-5/20II/GII.P7/GII.B

30257, 34B67, 39077

3798 VPI AB03S780 3798 8208 12618, 17028, 21438, 25848, Norwalk-like virus

3D258, 346B8, 39B78

3799 VPI AY038599 3799 8209 12619. 17029, 21439, 25849, human calicivirus NLV/VA97207/I997

30259, 34669, 39079

38DD VPI AY054299 3800 8210 12620, 17030, 21440, 25850, human calicivirus NLV/ldaho

30260. 34670, 39080 Falls/378/1996/OS

38DI VPI AFI95848 3801 8211 12621, 17031. 21441. 25851. human calicivirus strain

3D261, 34671, 39081 Hu/NLV/AmstErdam/98-l8/l998/NET

3802 VPI AB303927 3802 8212 12622, 17032, 21442, 25852. norovirus Hu/GGII.4/0tr _B chtD58/200l/NL

30262, 34672, 39082

3803 VPI AY038B00 3803 8213 12623, 17033, 21443, 25853, human calicivirus NLV/VA98387/I998

30263, 34673, 39083

3804 VPI AF080554 3804 8214 12624, 17034, 21444, 25854, Norwalk-like virus sp.

30264, 34674, 39084

3805 VPI AB234778 3805 8215 12625, 17035, 21445, 25855, norovirus Hu/GII-4/Matsudo/02l07l/2002/JP

30265.34B75, 39085

380B VPI AB303022 380B 82IB 12626, I703B, 21446, 25856. norovirus Hu/GGII.4/Tiel00l/I995/NL

30266, 34676, 39086

3807 VPI AY532I28 3807 8217 12627. 17037, 21447, 25857, norovirus Hamburg048/I997/GE

30267, 34677, 39087

3808 VPI AY532II3 3808 8218 12628, 17038, 21448, 25858, norovirus Freiburg253/I998/GE

30ZB8, 34B78, 39088

3809 VPI EU0784DB 3809 8219 I2G29, 17039, 21449, 25859, norovirus Hu/ ichmond/I994/OSA

302B3, 34B79, 39089 3810 VPI AF472B23 38IB 822B I2B3B. I7B40, 2I45B. 258BB, human calicivirus NLV/DIJ0NI7I/96

3B270, 34B8D, 33B3B

3811 VPI AF427II4 3811 8221 12631, 17041, 21451, 258BI, human calicivirus

3D271, 34B81, 33031 NLV/Frankfurt(0der)/l70/99/DE

3812 VPI AY532II4 3812 8222 I2B32, 17042, 21452, 258B2, nornvirus Erlangenl95/I997/GE

3B272, 34B82, 33032

3813 VPI KF8D65B5 3813 8223 I2B33, 17043, 21453, 258B3, nnravirus Hu/GII.4/patient_C/2DI0/USA

3D273, 34B83.33B33

3814 VPI JD4784D7 3814 8224 I2B34, 17044, 21454, 258B4, nornvirus Hu/Gll.4/I397/0SA

3B274, 34B84, 33094

3815 VPI AB303B23 3815 8225 I2B35, 17045, 21455, 258B5, nnrovirus Hu/GGII.4/DenHaagOI5/2000/NL

30275, 34B85, 3B035

38IB VPI AF427I2D 38IB 822B I2B3B, I704B, 2I45B, 258BB, human calicivirus NLV/BeEskaw/l24/00/0E

3027B, 3468B.33036

3817 VPI AY532I34 3817 8227 I2B37, 17047, 21457, 258B7, norovirus Hamburg23B/l337/GE

3B277, 34687, 33QS7

3818 VPI AY532IIB 3818 8228 I2B38, 17048, 21458, 258B8, nnrovirus Dresden245/I997/GE

3B278, 34B88, 33038

38IB VPI AY532II2 3813 8223 12633, 17043, 21453, 258B3, nornvirus Freiburg024/I337/GE

30273, 34B88, 33033

382D VPI KX5I4275 382B 823B I2B40, I7D50, 21460, 25870, narovirus GII.4

30280, 34630, 33IBB

3821 VPI KF8B65I0 3821 8231 12641, 17051, 21461, 25871, narovirus Hu/GII,4/patiBnt_C/20IO/USA

30281, 34691, 39101

3822 VPI EUB784ID 3822 8232 12642, 17052, 21462, 25872, norovirus Hu/GCanyon/2002/OSA

30282, 34B32, 33102

3823 VPI AF427I23 3823 8233 12643. I7D53, 21463, 25873, human calicivirus NLV/Berlin/435/BO/OE

30283.34633, 33IB3

3824 VPI AY532I35 3824 8234 I2B44. 17054, 21464, 25874, norovirus Hamburg3l6/I338/GE

30284, 34694, 39104

3825 VPI AY532I25 3825 8235 12645, 17055, 21465, 25875, narovirus Bochum224/l398/GE

30285, 34695, 39105

382B VPI AJ277BIB 382B 823B 12646, 17056, 21466, 2587B, human calicivirus HU/NLV/Symgreen/95/OK

30286, 34696, 33106 3827 VPI AFD8055G 3827 8237 I2B47, 17057, 2I4B7, 25877, Norwalk-like virus sp.

30287, 34697, 39ID7

3828 VPI AF080550 3828 8238 I2B48, 17058, 2I4B8, 25878, Norwalk-like virus sp.

30288, 34B98, 39108

3829 VPI EU078407 3829 8239 I2B49, 17059, 2I4B9, 25879, norovirus Hu/Houston/1995/USA

30289, 34699, 39109

3830 VPI AB08378I 3830 8240 I2B50, 17060, 21470, 25880, Norwalk-like virus

30290, 34700, 39110

3831 PI AF427I22 3831 8241 12651, 17061, 21471, 25881, human calicivirus NLV/BBrlin/491/OO/DE

30291, 34701, 39111

3832 PI AY532I33 3832 8242 12652, 17062, 21472, 25882, norovirus Hamburgl89/I997/GE

30292, 34702, 38112

3833 VPI AY532I3I 3833 8243 12653, I70B3, 21473, 25883, narovirus Hamburgl39/IB97/GE

30293, 34703, 39113

3834 VPI AY532I2I 3834 8244 I2B54, 17064, 21474, 25884, norovirus Bochum03l/I997/GE

3D294, 34704, 39114

3835 VPI AY532II5 3835 8245 12655, 17065, 21475, 25885, norovirus DrEsdenl53/l997/GE

30295, 34705, 39115

383B VPI F8D6530 383B 824B 12656, I7D6B, 21476, 25886. norovirus Hu/GII.4/patient_B/20IO/USA

30296, 3470B, 39116

3837 VPI KF8065I3 3837 8247 12657, 17067, 21477, 25887, norovirus Hu/GII.4/patient_C/20IO/USA

30297, 34707, 39117

3838 VPI AY74I8I1 3838 8248 12658, I70B8, 21478, 25888, narovirus Hu/NLV/DresdBnl74/pOS- 30298, 34708, 39118 Norll/1997/GE

3839 VPI AY532I22 3839 8249 I2B59, 17069, 21470, 25889, narovirus Bachuml08/I997/GE

302B9, 34709, 39119

3840 VPI AY532I20 3840 8250 I2B60, 17070, 21480, 25890, noravirus Bochum026/I997/GE

30300, 34710, 39120

3841 VPI AY532III 3841 8251 12661. 17071, 21481, 25891, norovirus Freiburg057/1997/GE

30301, 34711, 39121

3842 VPI AF080558 3842 8252 I2B62, 17072, 21482, 25892, Norwalk-likE virus sp.

30302, 34712, 39122

3843 VPI KF806508 3843 8253 I2B63, 17073, 21483, 25893, noravirus Hu/GII.4/patient_C/2DI0/USA

30303, 34713, 39123 3844 VPI AF4257BB 3844 8254 I2BB4, 17074, 21484, 25894, human calicivirus NLV/Dillingen 259/OI/DE

30304, 34714, 39124

3845 VPI AJ583B72 3845 8255 I2BB5, 17075, 21485, 25895, Norwalk virus

303D5, 34715, 39125

384B VPI AY532IIB 384B 825B I2BBB, I707B, 2I48B, 2589B, narovirus Bachum024/I998/GE

3030B, 347IB, 39I2B

3847 VPI AFD80552 3847 8257 I2BB7, 17077, 21487, 25897, Norwalk-likB virus sp.

30307, 34717, 39127

3848 VPI X5I4I77 3848 8258 I2BB8, 17078, 21488, 25898, norovirus GII.4

30308, 34718, 39128

3849 VPI F80B5I4 3849 8259 I2BB9, 17079, 21489, 25899, norovirus Hu/GII.4/patient_C/2DI0/USA

30309, 34719, 39129

3850 VPI AB3D3B25 3850 82B0 I2B70, 17080. 21490, 259D0, norovirus

30310, 34720, 39130 Hu/GGII.4/Leeuwarden043/2000/NL

3851 VPI KF80B534 3851 82BI 12671, 17081, 21491, 25901, norovirus Hu/GII.4/patient_B/20IO/USA

30311, 34721, 39131

3852 VPI KF80B5I9 3852 82B2 12672, I7D82, 21492, 25902, norovirus Hu/GII.4/patient 5mo/20l0/0SA

30312, 34722, 39132

3853 VPI AB303924 3853 82B3 12673, 17083, 21493, 25903, norovirus

30313, 34723, 39133 Hu/GGII.4/WaddinxvBenOIG/2000/NL

3854 VPI DQ975270 3854 82B4 12674, 17084, 21494, 25904, norovirus Hu/GII-4/0saka/l998/JPN

30314, 34724, 39134

3855 VPI AF4I4424 3855 82B5 12675, 17085, 21495, 25905, Nnrwalk-like virus NLV/Miami

30315, 34725, 39135 Beach/326/1995/OS

3856 VPI LCD489B4 385B 82BB I267B, I708B, 2I49B, 2590B, norovirus Hu/GII/3-2l5/TokyD/l995/JPN

30316, 34726, 39I3B

3857 VPI ABB847D5 3857 82B7 I2B77, 17087, 21497, 25907, norovirus Hu/GII/53-l/TokyD/l980/JPN

30317, 34727, 39137

3858 VPI F8DB523 3858 82B8 12678, 17088, 21498, 25908, norovirus Hu/GII.4/patient 5mo/20IO/USA

30318, 34728, 39138

385B VPI AY532I29 3859 82B9 I2B79, 17089, 21499, 25909, norovirus Hamburgl35/I998/GE

30319, 34729, 39139

38B0 VPI AY532I24 38B0 8270 I2B80, 17090, 21500, 25910, norovirus Bochum220/I997/GE

30320, 34730, 39140 3861 VPI KX5I43D9 3861 8271 12681, 17091, 21501, 25911, norovirus GII.4

30321, 34731, 39141

3862 VPI X5I4308 3862 8272 12682, 17092, 21502, 25912, norovirus GII.4

30322, 34732, 39142

3863 PI KX5I4283 3863 8273 12683, 17093, 21503, 25913, norovirus GII.4

30323, 34733, 39143

3864 VPI X5I4I94 3864 8274 12684, 17094, 21504, 25914, norovirus GII.4

30324, 34734, 39144

3865 VPI KY424340 3865 8275 12685, 17095, 21505, 25915, norovirus GII.4

30325, 34735, 39145

3866 VPI LC0I66D6 3866 8276 12686, 17096, 21506, 25916, norovirus Hu/JP/20D4/GII.4/Sakai/0l- 30326, 34736, 39146 inpatiEnt8-54d-l

3867 VPI FJ537I36 3867 8277 12687, 17097, 21507, 25917, norovirus Hu/Gll.4/CHDC3967/I988/0S

30327, 34737, 39147

3868 VPI AY532II7 3868 8278 12688, 17098, 21508, 25918, norovirus DrEsden267/l997/GE

30328, 34738, 39148

3869 PI KX5I4279 3869 8279 12689, I709B, 21509, 25919, norovirus GII.4

30329, 34739, 39149

387D VPI LCDI6602 387D 8280 12690, 17100, 21510, 25920, norovirus Hu/JP/2004/GII.4/Sakai/0l- 30330, 34740, 39150 inpatient8-29d-l

3871 VPI AFI45896 3871 8281 12691, 17101. 21511, 25921, cambErwEll virus

30331, 34741, 39151

3872 VPI AB684704 3872 8282 12692, 17102, 21512, 25922, norovirus Hu/GII/52-2/Tokyo/l980/JPN

30332, 34742, 39152

3873 VPI JX40I279 3873 8283 12693, 17103, 21513, 25923, norovirus Hu/GII.4/CI27/GF/l978

30333, 34743, 39153

3874 VPI G0389627 3874 8284 12694, 17104, 21514, 25924, synthetic construct

30334, 34744, 39154

3875 VPI AF425763 3875 8285 12695, 17105, 21515, 25925, human calicivirus NLV/BErlin/159/98/DE

30335, 34745, 39155

3876 VPI AY532I27 3876 8286 12696, 17106, 21516, 25926, norovirus Bochum339/l997/GE

30336, 34746, 39156

3877 PI AY532II8 3877 8287 12697, 17107, 21517, 25927, norovirus Dresden3l9/IB97/GE

30337, 34747, 39157 3878 VPI KX5I4326 3878 8288 I2B08, 17108, 21518, 25828, norovirus BII.4

30338, 34748, 30158

3878 VP1 X5I4264 3879 8289 I2B99, 17109. 21510, 25020, norovirus BII.4

30339, 34740, 39159

388D VPI X5I4I7I 388D 8200 12700, 17110. 21520, 25030, norovirus BII.4

30340, 34750, 30IB0

388! VPI KX5I4I70 3881 8291 12701, I7III, 21521, 25031, norovirus GII.4

30341, 34751, 39IBI

3882 VPI F80G533 3882 8202 12702, 17112. 21522, 25932, norovirus Hu/GII.4/patientJ/2BIO/0SA

30342, 34752, 30IB2

3883 VPI KF806528 3883 8283 12703, 17113, 21523, 25933, norovirus Hu/GII.4/patient_B/20IO/USA

30343, 34753.39IB3

3884 VPI KF8DB527 3884 8294 12704, 17114. 21524. 25034. narovirus Hu/GII.4/patientJ/20IO/USA

30344, 34754, 39IB4

3885 VPI KX5I426I 3885 8285 12705, 17115. 21525, 25935, norovirus GII.4

30345, 34755, 30IB5

388G VPI ABB84720 3886 820B I270B, I7IIB. 2I52B, 25936. norovirus Hu/GII/64-3/Tokya/l083/JPN

3034B.34756, 30I6B

3887 VPI LCDIBB05 3887 8207 12707, 17117. 21527, 25037, norovirus Hu/JP/20B4/GII.4/Sakai/0l- 30347, 34757, 39IB7 inpatient8-28d-4

3888 VPI KF80B528 3888 8208 12708, 17118. 21528. 25938, norovirus Hu/GII,4/patient_B/20IO/USA

30348, 34758.30168

3880 VPI JXD2328B 3889 8209 12700, 17119, 21529, 25030, norovirus Hu/GII.4/CHDC51BI/IB74/USA

30340, 34750, 30IB0

3890 VPI FJ537I37 3890 8300 12710, 17120, 21530, 25040, norovirus Hu/GII.4/CHDC4l08/l087/US

3D350, 34760, 39170

3801 VPI X7B7IB 3891 8301 12711, 17121. 21531, 25041, caliciviridaB

30351, 34761, 30171

3892 VPI KX5I4328 3892 8302 12712, 17122, 21532, 25042, norovirus GII.4

30352, 347B2, 3BI72

3893 VPI KX5I420I 3893 8303 12713, 17123, 21533, 25043, norovirus GII.4

30353, 34763, 39173

3884 VPI AB985442 3894 8304 12714, 17124, 21534. 25944, norovirus Hu/GII/2-4G/TokyD/l987/JPN

30354.347B4, 30174 3895 VPl LC0IBB04 3895 8305 12715. 17125, 21535, 25945, norovirus Hu/JP/2004/GII.4/Sakai/0l- 30355, 347B5, 39175 inpatiBnt8-29d-3

389B PI KF80B532 389B 830B I27IB, 17126. 2I53B, 2594B, norovirus Hu/GII.4/patient_B/20IO/USA

30356, 347BB, 39I7B

3897 VPl FJ537I38 3897 8307 12717, 17127, 21537, 25947, norovirus Hu/GII.4/CHDC487l/l977/US

30357, 347B7, 39177

3898 VPt AY030098 3898 8308 12718, 17128, 21538, 25948, human calicivirus H./NIV/GII/MDI34- 30358.347B8, 39178 7/I987/0S

3899 VPl AY532I30 3899 8309 12719, 17129, 21539, 25949, norovirus Hamburgl37/I997/GE

30359, 34769, 39179

39D0 VPl KX5I4286 3900 83I0 12720. 17130, 21540, 25950, norovirus GII.4

303B0, 34770, 39180

390I VPl KX5I4202 390I 83II 12721, 17131, 21541, 25951, norovirus GII.4

30361.34771, 39181

39DZ VPl 0Q358208 3902 83I2 12722, 17132, 21542, 25952. synthetic construct

30362, 34772, 39182

3903 VPl AF4I4425 3903 83I3 12723, 17133, 21543, 25953, Norwalk-like virus NLV/Burwash

30363, 34773, 39183 Landing/331/1995/US

3904 VPl KX5I4348 3904 83I4 12724, 17134, 21544, 25954, norovirus GII.4

30364, 34774, 39184

3905 VPl KX5I4287 3905 83I5 12725, 17135, 21545, 25955, norovirus GII.4

30365, 34775, 39185

3906 VPl X5I4I83 390B 83IB 12726, 17136, 21546, 25956, norovirus GII.4

30366, 34776, 39186

3907 VPl KX5I4I74 3907 83I7 12727, 17137, 21547, 25957, norovirus GII.4

30367, 34777. 39187

3908 VPl KF42979I 3908 83I8 12728. 17138, 21548, 25958. norovirus Hu/GII.4/NIHICI.5/20ll/OSA

30368, 34778, 39188

3909 VPl AF427II5 3909 83I9 12729, 17139, 21549, 25959, human calicivirus

30369, 34779, 39189 NLV/Ludwigslust/218/99/DE

39I0 VPl KX5I43I4 39I0 8320 12730, 17140, 21550, 25960, norovirus GII.4

30370. 34780.39190

39II VPl X5I4208 39II 832I 12731, 17141. 21551, 25361. norovirus GII.4

30371. 34781, 39191 39I2 VPI X5I42DB 3912 8322 12732, 17142, 21552, 259B2, norovirus GII.4

3D372, 34782, 39192

39I3 VPI X5I4I98 3913 8323 12733, 17143, 21553, 259B3, norovirus GII.4

3D373, 34783, 39IB3

3BI4 VPI KX5I4I9I 3914 8324 12734, 17144. 21554, 25964, norovirus GII.4

3D374, 34784, 39194

33I5 VPI KX5I4I87 3915 8325 12735, 17145, 21555, 259B5, norovirus GII.4

3D375, 34785, 39195

39IB VPI KX5I4I80 39IB 832B I273B, 17146, 21556, 259BB, norovirus GII.4

30376, 3478B, 33I3B

33I7 VPI GU5982I3 3917 8327 12737, 17147, 21557, 25367, synthetic construct

30377, 34787, 33137

3918 PI KX5I43B5 3918 8328 12738, 17148, 21558, 259B8, norovirus GII.4

3D378, 34788, 33138

3913 VPI KX5I4304 3919 8329 12733, 17143, 21553, 25369, norovirus GII.4

30379, 34789, 39199

3B20 VPI KX5I43D2 3920 8330 12740, 17150, 2I5B0, 25970, norovirus GII.4

30380, 34790, 39200

3921 VPI KX5I4207 3921 8331 12741, 17151. 21561, 25971, norovirus GII.4

30381, 34791, 392DI

3922 VPI X5I4I92 3922 8332 12742, 17152, 21562, 25972, norovirus GII.4

30382, 34792.39202

3923 VPI F8DB525 3923 8333 12743, 17153, 21563, 25973, norovirus Hu/GII.4/patient_B/20IO/USA

30383.34793, 33203

3924 VPI KC4B2I95 3924 8334 12744, 17154, 21564, 25974. norovirus Hu/GII.4/IT00/ITA

30384, 34794.39204

3925 VPI AF427IIB 3925 8335 12745, 17155. 21565, 25975, human calicivirus NLV/Ludwigslust/22l/99/DE

3D385, 34795, 39205

392B VPI X514337 392B 833B 12746, 17156, 21566, 25976. norovirus GII.4

30386, 3479B, 39206

3927 VPI KX5I4255 3927 8337 12747, 17157, 21567, 25977, norovirus GII.4

30387, 34797, 39207

3928 VPI KX5I42ID 3928 8338 12748, 17158, 21568, 25978, norovirus GII.4

30388, 34798, 39208 3929 VPI KX5I4I82 3929 8339 12749. 17159. 2I5B9, 25979. noravirus GII.4

3D389, 34799, 39209

393D VPI AF4257G4 3930 8340 12750, I7IB0, 21570, 25980, human calicivirus NLV/Berlin/238/98/DE

3D390, 34800, 39210

3931 VPI KX5I4355 3931 8341 12751, I7IBI, 21571, 25981, noravirus GII.4

30391.34801.39211

3932 VPI KX5I4345 3932 8342 12752, 17162, 21572, 25982, narovirus GII.4

30392, 34802, 39212

3933 VPI KX5I4204 3933 8343 12753, 17163. 21573, 25983, narovirus GII.4

30393, 34803, 39213

3934 VPI F7I2492 3934 8344 12754, 17164, 21574, 25984, noravirus Hu/GII.4/NIHICI.8/2DI2/USA

30394, 34804, 39214

3935 VPI DQ078829 3935 8345 12755, 17165, 21575, 25985, noravirus Hu/GII.4/Sydney348/970/A0

30395, 34805, 39215

3936 VPI KX5I4370 393B 834B I275B, 171GB. 2I57B, 25986. narovirus GII.4

30396, 34806, 39216

3937 VPI X5I4332 3937 8347 12757, 17167, 21577, 25987, narovirus GII.4

30397.34807, 39217

3938 VPI KX5I4276 3938 8348 12758, 17168, 21578, 25988, narovirus GII.4

30398, 34808, 39218

3939 PI KX5I425G 3939 8343 12759, 17163. 21579. 25989, noravirus GII.4

30399, 34809, 39219

394D VPI KX5I42D9 394D 8350 12760, 17170, 21580, 25990, noravirus GII.4

30400, 34810, 39220

3941 VPI X5I42D5 3941 8351 12761, 17171, 21581, 25991, norovirus GII.4

30401, 34811, 39221

3942 VPI KX5I4200 3942 8352 12762. 17172, 21582, 25992, noravirus GII.4

30402, 34812, 39222

3943 VPI KX5I4I9B 3943 8353 12763, 17173, 21583, 25993, norovirus GII.4

30403, 34813, 39223

3944 VPI AB985437 3944 8354 12764, 17174, 21584, 25994, norovirus Hu/GII/2-37/Tokyo/l987/JPN

30404, 34814, 39224

3945 VPI F7I2434 3945 8355 12765, 17175, 21585, 25995, norovirus Hu/Gll.4/NIHICI.7/20I2/USA

30405, 34815, 39225 334B VPI X5I43I5 394B 835B 12766, 17176, 21586, 25996, norovirus GII.4

304D6, 34816, 33226

3947 VPI X5I4IB9 3947 8357 12767, 17177, 21587, 25937, norovirus GII.4

30407, 34817, 33227

3948 VPI X5I4I7B 3948 8358 12768, 17178, 21588, 25998, norovirus GII.4

30408, 34818, 39228

394B PI X5I4360 3343 8353 12769, 17179, 21589, 25999, norovirus GII.4

3D409, 34819, 39229

395D VPI X5I4347 3350 83B0 12770, 17180, 21590, 26000, norovirus GII.4

30410, 34820, 39230

395I VPI ABB84B75 3351 8361 12771, 1 ^* 71 St. 21591, 26001, norovirus Hu/GII/2l-5/ ya/l975/JPN

30411, 34821, 39231

3952 VPI KX5I43B9 3952 8362 12772, 17182, 21592, 2B002, norovirus GII.4

30412, 34822, 39232

3953 VPI X5I43ID 3953 83B3 12773, 17183, 21593, 2B003, norovirus GII.4

30413, 34823, 39233

3954 VPI X5I4I85 3954 83B4 12774, 17184, 21594, 2B004, norovirus GII.4

30414, 34824, 39234

3955 VPI X514IS1 3955 8365 12775, 17185, 21595, 2B0D5, norovirus GII.4

30415, 34825, 39235

395B VPI F7I2493 395B 8366 12776, 17186, 21596, 26006, norovirus Hu/Gll.4/NIHICI.I0/20I2/USA

30416.34826, 39236

3057 VPI FJ4IIIBB 3357 8367 12777, 17187, 21597, 26007, norovirus Hu/GII.4/Wellington/l995/USA

30417, 34827, 39237

3B58 VPI AF427I2I 3358 83B8 12778, 17188, 21598, 26008, human calicivirus

30418, 34828, 39238 NLV/KoenigswusterhausEn/l30/00/0E

3959 VPI F429787 335B 8363 12779, 17189, 21590, 26009, norovirus Hu/Gll.4/NIHIC28.5/20I2/USA

30419, 34829, 39239

39BD VPI A8933728 3360 8370 12780, 17130, 21600, 26010, norovirus Hu/GII.4/Akita5/2D09/JP

30420, 34830, 39240

39BI VPI X5I434B 3361 8371 12781, 17101. 21601, 2BDII, norovirus GII.4

30421, 34831, 39241

39B2 VPI KX5I4249 3362 8372 12782, 17192, 2IBD2, 26012, norovirus GII.4

30422, 34832, 39242 3963 VPI F4297B0 39B3 8373 I2783. I7I93, 2I603, 260I3, noravirus Hu/GII.4/NIHIC28.4/ZDI2/USA

30423, 34833, 39243

3064 PI AB303929 39B4 8374 I2784, I7I94, 21B04, 2B0I4. norovirus Hu/GGII.4/EmmenE006/2002/NL

30424, 34834, 3B244

30B5 VP! KX5I43B3 39B5 8375 I2785, I7I95, 2IB05, 260I5, noravirus GII.4

30425, 34835, 39245

3966 VPI KX5I4357 39B6 8376 I2786, I7I96. 2IB06. 260I6, noravirus GII.4

30426, 34836, 3924B

30B7 VPI KX5I4240 39B7 8377 I2787, 17197. 2IB07, 2B0I7, noravirus GII.4

30427, 34837, 39247

3968 PI AF4I44I7 39B8 8378 12788, 17198, 2IB08, 2B0I8, Narwalk-liko virus NLV/UK3- 30428, 34838, 39248 I7/I2700/I992/GB

30BQ VPI KX5I4303 3969 8379 12789, 17199, 2IB09, 2B0I9, noravirus GII.4

30429, 34839, 39249

3970 VPI KX5I4273 3970 8380 12790, 17200, 2IBID, 2B020, noravirus GII.4

30430, 34840, 3925D

397I VPI X5I4323 397I 838I 12791, 17201, 2IBII, 2B02I, noravirus GII.4

3D431.34841, 39251

3972 VPI KX5I43B4 3972 8382 12792, 17202, 2IBI2, 26022, noravirus GII.4

30432, 34842, 39252

3973 VPI KX5I4338 3973 8383 12793, 17203, 21613, 2B023, noravirus GII.4

3D433, 34843, 3B253

3974 VPI KX5I43IE 3974 8384 12794, 17204, 21614. 2B024, noravirus GII.4

30434, 34844, 39254

3975 VPI KX5I4356 3975 8385 12795, 17205, 21615, 26025, noravirus GII.4

30435, 34845, 39255

3976 VPI X5I4349 397B 8386 12796, I720B, 21616, 26026, noravirus GII.4

3D43B, 3484B, 3B25B

3977 VPI KX5I42I7 3977 8387 12797, 17207, 21617, 26D27, norovirus GII.4

30437, 34847, 39257

3978 VPI X5I4324 3978 8388 12798, 17208, 21618. 26028, noravirus GII.4

30438.34848, 30258

3979 VPI X5I430B 3979 8389 12799, 17209. 21619. 2602B, noravirus GII.4

30439, 34849, 39259 3980 VPI ABI8B0B3 308D 839D 12800, 17210, 2IB20, 2B030, norovirus Hu/0C02l98/2002/JP

30440, 34850, 392BD

seal VPI AF4DB793 3081 8301 12801, 17211. 21621. 2B03I, nornvirus Gil

30441, 34851, 39261

3982 PI KX5I4223 3B82 8392 12802. 17212, 21622, 26032, norovirus GII.4

30442, 34852, 39262

3983 VPI KX5I43I8 3983 8393 12803, 17213, 21623, 26033, norovirus GII.4

30443, 34853, 39263

3984 VPI ABI8BDB5 3984 8304 12804, 17214, 21624, 2B034. norovirus Hu/0C02202/2002/JP

30444, 34854, 392B4

3985 VPI KX5I4307 3985 8385 12805, 17215, 2IB25, 2B035, norovirus GII.4

30445, 34855, 39265

3986 VPI LC048948 398B 839B 12806, 17216. 21626, 2603B, norovirus Hu/GII/3-l57/Tokya/l994/JPN

30446, 3485B, 39266

3987 VPI LCD48908 3987 8397 12807, 17217, 21627, 26037, norovirus Hu/GII/3-G4/Tokyo/l993/JPN

30447, 34857, 39267

3988 VPI X514312 3988 8398 12808, 17218. 21628, 26038, norovirus GII.4

30448, 34858, 39268

3989 VPI KX5I4237 3989 8399 12809, 17219. 21629. 26030, nornvirus GII.4

30449, 34859, 39269

3990 VPI DQ4I0907 3990 8400 12810. 17220, 21630, 26040, nornvirus Hu/BEijing/CR2905/2004/CHN

3D450, 34860, 39270

399I VPI JN975543 3991 8401 12811. 17221, 21631, 26041. murinE norovirus

30451.348BI, 39271

3902 VPI JN97554I 3992 8402 12812, 17222, 21632, 2B042, murine norovirus

30452.34862, 30272

3993 VPI KFII3526 3993 8403 12813, 17223, 2IB33, 2B043, murine norovirus

30453, 34863, 39273

3994 VPI KFII3527 3994 8404 12814, 17224, 21634, 26D44, murine norovirus

30454, 34864, 39274

3995 VPI KM458057 3995 8405 12815, 17225, 21635, 26045, murine norovirus

30455, 348G5, 39275

399G VPI ABBB2855 399B 840B 12816. 17226. 21636, 26046, norovirus Hu/GII.2/0CD6008-3/2006/JP

30456, 34866, 39276 3937 VPI AB803337 3337 84B7 I28I7, I7227, 2IB37, 2BB47, norovirus Hu/GII.I3/03N3798/2009/NP

30457, 348B7.33277

3338 VPI AB8I0DDI 3338 84B8 I28I8, I7228, 2IB38, 2B048, nornvirus Hu/GII.I3/ION3922/20IO/NP

3D458, 348B8, 33278

3333 VPI AB8DB332 3333 8403 I28I3, I7223. 2IB33, 2BB4S. narovirus Hu/GII.I3/09N372l/2009/NP

30453, 348B3, 33273

4DDG VPI AYI3B7BI 4BBB 84ID I2820, I7230, 2IB40, 2B050, human calicivirus NLV/ 7/I999/US

304B0, 34870, 3B280

4DBI VPI KF8DB495 4GBI 84II I282I, 17231. 21641, 2B05I, norovirus Hu/GII.4/patient_A/20IO/USA

304BI, 34871, 39281

4DD2 VPI KF80B5B3 4BB2 84I2 12822, 17232, 2IB42, 2B052, narovirus Hu/GII.4/patient_A/20IO/OSA

3D4B2, 34872, 39282

4BG3 VPI KF7I25GB 4BB3 84I3 12823, 17233, 2IB43, 2B053, norovirus Hu/Gll.4/NIHICI.I2/20I2/USA

304B3, 34873, 39283

4BD4 VPI KF7I2507 4GB4 84I4 12824, 17234, ZIB44, 2B054, narovirus Hu/Gll.4/NIHICI.II/20I2/0SA

304B4, 34874, 33284

4DD5 VPI JX4BI28I 4BB5 84I5 12825, 17235, 2IB45, 2BB55, narovirus Hu/Gll/T09l/TN/I976

304B5, 34875, 33285

4DDB VPI KF8BB526 4BBB 84IB I282B, I723B, 2IB4B, 2BB5B, narovirus Hu/GI /patientJ/2010/USA

304BB, 3487B, 3328B

4DD7 VPI KF806500 4GB7 84I7 12827, 17237, 2IG47, 2B057, norovirus Hu/GII.4/patient_A/20IO/OSA

3D4B7, 34877, 33287

4DBB VPI KF80B438 4DD8 84I8 12828, 17238, 2IB48, 2GD58, norovirus Hu/GII.4/patient_A/20IO/USA

304B8, 34878, 33288

4DD3 VPI F42B768 40D3 84IS 12823, 17233, 2IB4B, 2B059, norovirus Hu/Gll,4/NIHICI.I3/20I2/USA

3D4B9, 34879.39289

4DIB VPI F8DB43B 4BIB 8420 12830, 17240, 2IB50, 2B0B0, norovirus Hu/GII.4/patient_A/20IO/USA

30470, 34880, 39290

40ll VPI F8DB499 4DII 842I 12831, 17241, 21651, 2B06I, norovirus Hu/Gll.4/patient_A/20!0/USA

30471, 34881, 39Z9I

4BI2 VPI F8DB437 40I2 8422 12832, 17242, 21652, 26062, narovirus Hu/Gfl.4/patient_A 2D1D/USA

30472, 34882, 39292

4BI3 VPI JNB33046 4BI3 8423 12833, 17243, 21653, 26D63, narovirus Hu/Gl.5/E57/UG/I975

3D473, 34883, 39293 4DI4 VPI AM2B34I8 40I4 8424 I2834, I7244. 2IB54. 2B0B4, norovirus Hu/GI/BabbacDmbe/l99G/GB

30474, 34884, 39294

4DI5 VPI KT732278 40I5 8425 I2835, I7245. 2IB55, 2B0B5, norovirus GI.5

30475, 34885, 39295

40IB VPI KT732277 40IB 842B I283B, I724B, 2IB5B, 2B0BB, naravirus GI.5

3047B, 3488B, 39296

4DI7 VPI J402295 40I7 8427 I2837, I7247, 2IB57, 2B0B7, norovirus Hu/Gl.5/Siklos-HUN5407/20I3/HON

30477, 34887, 39297

4DI8 PI AF4I440G 40I8 8428 IZ838, I7248, 2IB58, 2B0B8, Narwalk-like virus NLV/ Appalachicola

30478, 34888, 39298 Bay/3I8/I995/0S

4DIB VPI AB039774 40I9 8429 I2839, I7249, 2IB59, 26069, Narwalk-like virus

30479, 34889, 39299

402D VPI KPQG4095 4020 8430 I2840, I7250, IBB0. 2B070, norovirus GI.2

30480, 34890, 39300

402I VPI AB0456Q3 402I 843I I284I, I725I, 2IGBI, 2B07I, Norwalk-iike virus

30481, 34891, 3930I

4D22 VPI AF397905 4022 8432 I2842, I7252. 2IBB2, 2B072, human calicivirus NLV/Schwerin 003/00/DE

30482, 34892, 39302

4023 VPI AF4I4420 4023 8433 I2843, I7253, 2IBB3, 2B073, Narwalk-like virus NLV/Honolulu/3l4/l994/0S

30483, 34893, 39303

4D24 VPI AF427II9 4024 8434 I2844. I7254, 2IB64, 26074, human calicivirus NLV/Pirna/IIO/OO/DE

30484, 34894, 39304

4025 VPI AB0443BB 4025 8435 I2845, I7255, 2I665, 26075. Nurwalk-like virus

30485, 34895, 39305

4D2B VPI AB032758 402B 843B I2846, I725B, 2IBBB, 2B076, chitta virus

30486. 34896, 39306

4027 VPI AB039775 4027 8437 I2847, I7257, 2I6B7, 2B077, Norwalk-like virus

30487, 34897, 39307

4028 VPI AF4I44I8 4028 8438 I2848, 17258, 2IB68, 2B078, Norwalk-iike virus

30488, 34898, 39308 NLV/Westaver/302/1994/US

4029 VPI AF4257B9 4029 8439 I2849, I7259, 2IBB9, 2B079, human calicivirus NLV/Wiasbaden 294/OI/DE

30489, 34899, 39309

4030 VPI AF4I442I 4030 8440 I2850, I7260, 2I670, 26080, Norwalk-like virus NLV/Port

30490, 34900, 393I0 Canaveral/301/1994/US 403I VPI AF4I44I6 403I 844I I285I, I72BI, 2IB7I, 2BB8I, NDrwalk-like virus NLV/ iami/8l/l98E/US

30491, 34901. 3B3II

4032 VPI AF4I44I9 4032 8442 I2852, I72B2, 2I672, 2BB82. Norwalk-like virus

30432, 34902.393I2 NLV/Richmond/283/1994/US

4033 VPI AF425767 4D33 8443 I2853, I7263, 2IB73. 26083. human calicivirus NLV/Dillingen 39I/0I/0E

30493, 34903, 393I3

4034 VPI 0Q093065 4034 8444 I2854, I72B4, 2IB74, 26B84. Norwalk virus

30494, 34904, 393I4

4035 VPI JIB4507 4035 8445 I2855, I7265, 2I675, 2BB85, nnrovirus Hu/GII/Amsterdam/3/1995

30435.34305, 33315

4036 VPI P064090 4036 8446 12856, 17266, 21676. 26086, nnrovirus GII.I2

30496, 34906, 39316

4037 VPI AB303926 4037 8447 12857, 17267, 21677. 26087. nnrovirus Hu/BGII.4/SchiedamOI8/2GOI/NL

30497, 34907.39317

4038 VPI K0385I66 4038 8448 12858, 17268, 21678, 26D88, nornvirus GII.4

30498, 34908, 39318

4039 VPI JNB99045 4039 8449 12859, 17269, 21679, 26089, narnvirus Hu/Gl.6/HK60/CN/I977

30499, 34909, 39319

4040 VPI EF547395 4040 8450 12860, 17270, 21680, 26090. nornvirus Hu/0saka/00032l/2000/JP/3006

3D500, 34910, 39320

404I VPI AY502008 404I 845I 12861, 17271, 21681. 26091, nnrovirus Gl

30501.34911, 39321

4D42 VPI AY502007 4042 8452 12862. 17272, 21682, 26092, nornvirus Gl

30502, 34912, 39322

4043 VPI KC998959 4043 8453 12863, 17273, 21683, 26093, nnrovirus Hu/GI.6/TCH-099/0SA/2003

30503, 34913, 39323

4044 VPI BQ856464 4044 8454 12864, 17274, 21684, 26034. narnvirus Hu/GII.4/Beijing/55063/2007/CHN

30504, 34314, 33324

4045 VPI GD8564G3 4045 8455 12865, 17275, 21685, 26095, nnrovirus Hu/GII.4/BBijing/53S37/2007/CHN

30505, 34915, 39325

4046 VPI M036372 4046 845B 12866, 17276, 21686, 26036, nornvirus Hu/BI.Pb/GI.B/Kaohsiung/14-A- 30506, 34316, 39326 7/2BI4/TW

4047 VPI AF538678 4047 8457 12867, 17277, 21687, 26097, human calicivirus NLV/VA497/I999/0S

30507, 34317.33327 4048 VPI KC294I98 4048 8458 I2868, 17278, 2IB88, 2B098, norovirus rat/GI/KSI2/l305/DNK

30508. 349I8, 39328

4049 VPI KT732280 4049 8459 I2869, 17279, 2IB89, 2B0B9. norovirus GI.6

305D9. 349I9, 39329

4050 VPI LCI0I822 4050 8460 I2870, I7280. 2IB90, 2BI00, norovirus GI/Hu/Jp/20l3/GI,B/sl30l47

305I0, 34920, 39330

405! VPI KP40745I 405I 846I I287I, I728I, 2IB9I. 26I0I. norovirus Gl

305II, 34921, 3933I

4052 VPI LN854564 4052 8462 I2872, I7282. 2I692. 26ID2. norovirus GI/Hu/NL/2012/GI.B/Groningen

305I2, 34922, 39332

4053 VPI J0388274 4053 84B3 I2873, I7283, 2IB93, 26I03, norovirus

305I3, 34923, 39333 Hu/GI.G/ ingston/ACTI60D/20IO/AU

4054 VPI P027330 4054 8464 I2874, I7284, 2IB94, 26I04, norovirus Hu/GI.PB/GI.B/Changhua/14-BC- 305I4, 34924, 39334 I/20I4/TW

4055 VPI AF093797 4055 8465 I2875, I7285, 2IB95, 2BI05, Norwalk virus

305I5, 34925, 39335

4056 VPI AB8I0006 4056 846B I2876, I7286, 2IB9B, 26I06, norovirus Hu/GII.I3/ION444l/20IQ/NP

30516.34926, 39336

4057 VPI LCI0I825 4D57 8467 12877, 17287, 21697, 26107, norovirus Gl/Hu/Jp/2D02/Gl.5/0C020I80

30517. 34927, 39337

4058 VPI AB08I723 4058 8468 12878, 17288, 21698, 2BI08, Norwalk-like virus

30518, 34928, 39338

4059 VPI JN005886 4059 8469 12879, 17289, 21699, 26109, norovirus Hu/GI.7/TCH-0B0/0SA/2003

30519, 34929, 39339

4060 VPI AB758449 40B0 8470 12880, 17290, 21700, 26110, norovirus Hu/GI.7/2009/Miyagi/JP

30520, 34930, 3934D

406I VPI KXB07729 40BI 847I 12881, 17291, 21701, 26111. norovirus Hu/USA/201l/GI.P7_GI.7/CS5567

30521, 34931, 39341

4062 VPI JN899243 4062 8472 12882, 17292, 21702. 26112, norovirus Hu/GI.7/Providencel9l/20IO/USA

30522, 34932, 39342

4063 VPI AB8I0004 4063 8473 12883, 17293, 21703, 26113, norovirus Hu/GII.I3/ION4358/20IO/NP

30523, 34933, 39343

4064 VPI JNI83I63 4D64 8474 12884, 17294, 21704, 26114, norovirus

30524, 34934, 39344 Hu/GI.4/SI4/2008/LillaEdet/Sweden 4065 VPI EU3738I5 4065 8475 12885. 17295. 2I7D5, 26115. norovirus Hu/GII/LuckBnwalde591/2DD2/DE

30525, 34935, 39345

4066 VPI KC473547 4066 8476 I288B, I729B, 21706, 2BIIB, norovirus Hu/GI/HuzhDuNII/2008/CHN

30526, 34936, 39346

4067 VPI GQ266692 4067 8477 12887, 17297, 21707, 26117, norovirus Hu/Zuerich/P4dl/2007

30527, 34937, 39347

4068 VPI GQ266693 40B8 8478 12888, 17298, 2I7D8, 26118. norovirus Hu/Zuerich/P4d28l/2007

30528, 34938, 39348

4069 VPI EU0D4673 4QB9 8479 12889, 17299, 21709, 26119, murine norovirus GV/CR3/2005/USA

30529.34939, 39349

4070 VPI AB60I769 4D70 8480 12890, 17300, 21710, 2BI2D, murine norovirus

3D530, 34940, 39350

4071 VPI EU004676 4D7I 8481 12891, 17301, 21711, 26121, murine norovirus GV/CR6/2005/USA

30531, 34941, 39351

4072 VPI JQ237823 4072 8482 12892. 17302, 21712. 26122. murine norovirus GV/CRB/20D5/USA

30532, 34942, 39352

4073 VPI DQ223043 4073 8483 12893, 17303, 21713, 26123, murine norovirus 4

30533, 34943, 39353

4074 VPI JX048594 4074 8484 12894, 17304, 21714, 26124, murine norovirus

30534, 34944, 39354

4075 VPI GQ26669I 4075 8485 12895, 17305, 21715, 26125, norovirus Hu/Zuerich/P3dB83/2008

30535, 34945, 39355

4076 VPI GQ266690 407B 8486 I289B, 17306, 21716, 26126, norovirus Hu/Zuerich/P3dl/200E

30536, 3494B, 39356

4077 VPI JNI83I64 4077 8487 12897, 17307, 21717, 26127, norovirus Hu/GI.3/S26/2DD8/Lilla

30537, 34947, 39357 Edet/Sweden

4078 VPI AB809995 4078 8488 12898, 17308, 21718, 26128, norovirus Hu/GII.I3/09N3779/20D9/NP

30538, 34948, 39358

4079 VPI T732275 4D79 8489 12899, 17309, 21719, 26129, norovirus GII.I7

30539, 34949, 39359

4080 VPI AB8Q9938 4080 8490 12900, 17310, 21720, 26130, norovirus Hu/GII.I3/09N38IB/2009/NP

30540, 34950, 393B0

4081 VPI AB809B84 4081 8491 12901, 17311. 21721, 26131, norovirus Hu/GII.I3/09N354G/2009/NP

3D541, 34951, 39361 4082 VPI KT732276 4082 8492 I2902. 17312, 21722, 2BI32, norovirus G 11.1 ^* 7

30542, 34952, 393B2

4083 VPI AB8I0009 4083 8493 12303, 17313, 21723, 2BI33, nopovipus Hu/GII.I3/ION4488/20IO/NP

30543.34353, 393B3

4084 VPt KM4GI6B0 4084 8494 I29D4, 17314, 21724, 2BI34. noravirus 08-AG-I/20D8/GILP7/G1I.B

30544, 34354, 39364

4085 VPI JN400BI8 4085 8495 12905, 17315, 21725, 2BI35, noravirus Hu/GII-4/CGMH20/2009/TW

30545, 34355, 33365

4D8B VPI JQB53095 408B 849B I290B, 17316, 21726, 26136, norovirus Hu/0l/0 Y/2008

30546, 3435B, 333BB

4087 VPI JNI83IBI 4087 8497 12307, 17317, 21727, 2BI37, noravirus Hu/GI.7/S24/2008/lilla

30547, 34357, 33367 Edet/Sweden

4088 VPI KT906670 4088 8498 12308, 17318, 21728, 2BI38, noravirus GII.I7

30548, 34958, 333B8

408B VPI KT3D667I 4089 8499 12303, 17313, 21729, 26139. norovirus GII.17

3054S, 34359, 33363

4090 VPI AB8I00I3 409D 8500 12310, 17320, 21730, 2BI4B, norovirus Hu/GII.I3/ION4555/20IO/NP

3055B, 343B0, 33370

409I VPI E009B5ID 409I 850I 12311. 17321. 21731, 26141. norovirus Hu/noravirus/GII- 30551, 343BI, 33371 4/CeglEdl603/2002/H0N

4092 VPI E009B5I3 4092 8502 12312, 17322, 21732, 2BI42, norovirus Hu/norovipus/GII- 30552, 34362, 33372 4/Pecs2967/20Q7/H0N

4093 VPI E0B9B5I4 4093 85D3 12313, 17323, 21733, 26143, norovirus Hu/norovirus/GII- 3D553, 343B3, 33373 4/Kapuvar3D29/2007/H0N

4094 VPI EUB9G5I2 4094 8504 12914, 17324, 21734, 2BI44, norovirus Hu/norovirus/GII- 30554.34964, 39374 4/Mosonmagyarovar2594/2006/H0N

4095 VPI K03IIIBI 4095 8505 12915, 17325, 21735, 2BI45, norovirus Hu/GI.7/AlbertaEI404/20l2/CA

30555, 349B5, 39375

409B VPI KXB0773D 409B 850B 12916, I732B, 2I73B, 26146, norovirus Hu/USA/2DI4/GI.P7_GI.7/GA5043

3055B, 349B6, 3937B

4097 VPI E009B507 4097 85B7 12917. 17327. 21737, 2BI47, norovirus Hu/norovirus/GII- 30557, 34967.39377 4/Kiskunhalasl264/2002/HUN

4098 VPI AB8I0007 4098 85B8 12918, 17328. 21738, 26148, norovirus Hu/GII.I3/ION4487/20IO/NP

30558, 34968, 39378 4099 VPI AB809989 40B9 850B 12913, 17323, 21733, 2BI43, nnrovirus Hu/GIU3/D3M3B83/2DDB/NP

30559, 34BB3, 33373

4100 PI AB8I0000 4ID0 8510 12320, 17330, 21740, 2BI50, norovirus Hu/GII.I3/ION33l7/20IO/NP

305B0, 34970, 39380

4101 VPI AB809999 4IBI 8511 12921, 17331, 21741, 2BI5I. narovirus Hu/GII.I3/IDN3B52/ZDID/NP

305BI, 34971, 33381

4102 VPI FJ6B250I 4102 8512 12322, 17332, 21742, 2BI52, norovirus dog/BVI.I/HK0_Ca035F/2B07/HKB

3B5B2, 34972, 39382

4103 VPI FJB92500 4103 8513 12923, 17333, 21743, 2BI53, narovirus dag/GVI.I/HKO_Ca026F/2007/HKG

3D5B3, 34373, 33383

4104 VPI AB03I0I3 4104 8514 12924, 17334, 21744, 2BI54, human calicivirus NLV/Aichi/l24-89/JP

3B5B4, 34374, 39384

4105 VPI K0253442 4105 8515 12925, 17335, 21745, 2BI55, norovirus Gl.l

305B5, 34375, 33385

4106 VPI EF547392 4I0B 85IB I232B, I733B, 2I74B, 2BI5B, narovirus

305BB, 3497G, 3338B Hu/Maizuru/0305l2/2003/JP/4B5B

4107 VPI KT943503 4107 8517 I2B27, 17337, 21747, 2BI57, norovirus TFI/USA/2008

305B7, 34377, 33387

4108 VPI AY5020IB 4ID8 8518 12328, 17338. 21748, 2BI58, norovirus Bl

3D5B8, 34378, 33388

4109 VPI K025344B 4IB3 8513 12929, 17339, 21749, 2BI5S, norovirus Gl.l

305B9, 34373, 33383

4110 VPI 0253445 4110 852B 12930, 17340, 21750, 2BIBD, norovirus Gl.l

33570, 34380, 33330

4111 VPI KF038735 4111 8521 12331, 17341, 21751, 2BIBI, narovirus Hu/GI.I/CHA3A007/2008/USA

30571, 34981, 39391

4112 VPI KF03B732 4112 8522 12932, 17342, 21752, 2BIB2, norovirus Hu/GI.I/CHA5AOIO/2009/OSA

30572, 34382, 3B3B2

4113 VPI KF03B734 4113 8523 12333, 17343, 21753, 2BIB3, norovirus Hu/GI.I/CHAGAOI4/2009/OSA

30573, 34383, 393S3

4114 VPI KF033723 4114 8524 12334, 17344, 21754, 2BIG4, norovirus Hu/GI.I/CHAGA007/20IO/USA

30574, 34384, 33394

4115 VPI KF033737 4115 8525 12935, 17345, 21755, 2BIB5, norovirus

30575, 34385, 33335 Hu/BI.I/CHABA003_2003IID4/2009/USA 4116 VPI KF03873I 4IIB 852B I293B, I734B, 2I75B, 2BIBB, norovirus Hu/GI.I/CH4X0533/2D09/USA

3057B, 3498B, 3939B

4117 VPI KT732279 4117 8527 12937, 17347, 21757, 2BIB7, norovirus Gl.l

30577, 34987, 39397

4118 VPI FJ384783 4118 8528 12938, 17348, 21758, 2BIB8, norovirus Hu/GU/P7- 30578, 34988, 39398 587/2007/Stromstad/Sweden

4119 VPI E0085522 4119 8529 12939, 17349, 21759, 2BIB9, norovirus

30579, 34989, 39399 Hu/GI.I/MussBls/MI0nov2004/Foto/Sweden

4120 VPI L23828 4120 8530 12940, 17350, 2I7B0, 2BI70, Norwalk virus

30580, 34990, 39400

4121 VPI KX7B4843 4121 8531 12941, 17351, 2I7BI, 2BI7I, norovirus Gil

3D581, 34991, 39401

4122 VPI X7B484I 4122 8532 12942, 17352, 2I7B2. 2BI72, norovirus Gil

30582, 34992, 39402

4123 VPI KX7E4840 4123 8533 12943, 17353, 2I7B3, 2BI73, norovirus Gil

30583, 34993, 39403

4124 VPI KT8B4B87 4124 8534 12944, 17354, 2I7B4, 2BI74, norovirus Gil

30584, 34994, 39404

4125 VPI X7B4842 4125 8535 12945, 17355, 2I7B5, 2BI75, norovirus Gil

30585, 34995, 39405

4I2B VPI T8B4B85 4I2B 853G I294B, I735B, 2I7BB, 2GI7B, norovirus Gil

3058B, 3499B, 3940B

4127 VPI KT8B4B84 4127 8537 12947, 17357, 2I7B7, 2BI77, norovirus Gil

30587, 34997, 39407

4128 VPI KX7B483B 4128 8538 12948, 17358, 2I7B8, 2BI78, norovirus Gil

30588, 34998, 39408

4129 VPI X7B4845 4129 8539 12949, I735B, 2I7B9, 2BI79, norovirus Gil

30589, 34999, 394D9

4130 VPI KX7B4837 4130 8540 12950, I73B0, 21770, 2BI80, norovirus Gil

30590, 35000.39410

4131 VPI KX7B4838 4131 8541 12951, I73GI, 21771, 2BI8I, norovirus Gil

30591, 35001, 39411

4132 VPI K0B870IB 4132 8542 12952, I73B2, 21772, 2BI82, norovirus Gil

30592, 35002, 39412 4133 VPI KUB87DI5 4133 8543 12353, I73B3, 21773, 2BI83, noravirus Gil

30593, 35D03, 39413

4134 VPI KUG870I3 4134 8544 12954, I73B4, 21774, 2BI84, norovirus Gil

30534.35004, 39414

4135 VPI KX7G4839 4135 8545 12355, I73B5, 21775, 2BI85, noravirus Gil

30535, 35005, 33415

4136 VPI KX764844 4I3B 854B I235B, I73BB, 2I77B, 2BI8B, noravirus Gil

3059B, 3500B, 33416

4137 VPI KT8B4B8B 4137 8547 12357, I73B7, 21777, 2BI87, noravirus Gil

30537, 35007, 33417

4138 VPI UB87DI2 4138 8548 12358, I73B8, 21778, 2BI88, noravirus Gil

30598, 35008, 39418

4139 VP! KU6870I8 4139 8543 12359, I73B3, 21773, 2BI83, noravirus Gil

30593, 35003, 33419

4I4D VPI KUB8702I 4140 8550 I29B0, 17370, 21780, 26190, noravirus Gil

30600, 35010, 39420

4141 VPI KUB87020 4141 8551 12961, 17371, 21781, 26191, noravirus Gil

30BDI, 35011.33421

4142 VPI UB870I4 4142 8552 12362, 17372, 21782, 2BI92, narovirus Gil

30B02, 35DI2, 33422

4143 VPI KUB870I3 4143 8553 I29B3, 17373, 21783, 26193, norovirus Gil

30B03, 35013, 39423

4144 VPI KUB87DI7 4144 8554 I29B4, 17374, 21784, 2BI94, noravirus Gil

30B04, 35014, 39424

4145 VPI KUB87024 4145 8555 12965, 17375, 21785, 26195, norovirus Gil

30605, 35015, 39425

4I4B VPI KUB87022 4I4B 855B I296B, 17376, 2I78B, 2BI96. norovirus Gil

3060B, 35016, 39426

4147 VPI UB87D23 4147 8557 12367, 17377, 21787, 26137, norovirus Gil

30607, 35017, 33427

4148 VPI KX7B4847 4148 8558 12368, 17378, 21788, 26138. norovirus Gil

30608.35018.33428

4149 VPI X7B484B 4143 8553 12969, 17379, 21789, 26199, norovirus Gil

30609, 35019, 39429 4I5D VPI KX764833 4150 85B0 12970. 17380, 21790. 2B200. norovirus Gil

30BI0, 35020, 39430

4151 VPI KX764834 4151 85BI 12971, 17381, 21791, 2B20I, norovirus Gil

3DBII, 35021, 39431

4152 VPI KU687027 4152 85B2 12972, 17382, 21792, 2B202, norovirus Gil

30BI2, 35022, 39432

4153 VPI KX7B4835 4153 85B3 12973, 17383, 21793, 2B203, norovirus Gil

30BI3, 35023, 39433

4154 VPI KX764832 4154 85B4 12974, 17384, 21794, 2B204, norovirus Gil

30BI4, 35024, 39434

4155 VPI K0687025 4155 85B5 12975, 17385, 21795, 2B205, norovirus Gil

30BI5, 35025, 39435

4I5B VPI KUB8702B 4I5B 85BB I297B, I738B, 2I79B, 2B20B, norovirus Gil

30BIB, 3502B, 3943B

4157 VPI KUB87Q28 4157 85B7 12977, 17387, 21797, 2B207, norovirus Gil

30BI7, 35027, 39437

4158 VPI KX7B483I 4158 85B8 12978, 17388, 21798, 2B208, norovirus Gil

30BI8, 35028, 39438

4159 VPI JN2223BB 4159 85B9 12979, 17389, 21799. 26209, norovirus Hu/GI.G/DK/2010

30BI9, 35029, 39439

4IG0 VPI KM386679 4IB0 8570 12980, I739D, 21800, 2B2I0, norovirus 07-AC-I/2007/GII.P22/GII.5

30B20, 35030, 39440

4IGI VPI AY549I5B 4IBI 8571 12981, 17391, 21801, 26211. bovine Enteric calicivirus

30B21, 35031, 39441

4IG2 VPI AY549IB3 4IB2 8572 12982, 17392, 2I8D2, 26212, bovine enteric calicivirus

30622, 35032, 39442

4163 VPI AY549I59 4IB3 8573 12983, 17393, 21803. 26213, bovine enteric calicivirus

30623, 35033, 39443

4IG4 VPI AY549IBB 4IB4 8574 12984, 17394. 21804, 26214, bovine enteric calicivirus

30624, 35034, 39444

4IG5 VPI AF320II3 4IB5 8575 12985, 17395, 21805, 26215, Norwalk-like virus

30625, 35035, 39445

4IBG VPI AY549I53 4IBB 857B 12986, 17396, 21806, 26216, bovine enteric calicivirus

30626, 35036. 39446 4167 VPI AY543I57 4IB7 8577 12987. 17397, 21807, 2B2I7, bovine enteric calicivirus

30B27, 35037, 33447

4IB8 VPI AY543I58 4168 8578 12988, 17338, 21808, 26218, bovine enteric calicivirus

30628, 35038, 39448

41GB VPI AY543IB5 4IG9 8579 12989, 17399, 21809, 26219, bovine enteric calicivirus

30629, 35039, 39449

4I7B VPI AY543IG7 4170 8580 12990, 17400, 21810, 26220, bovine enteric calicivirus

30630, 35040, 39450

4171 PI AY549I54 4171 8581 12991, 17401, 21811. 26221, bovine enteric calicivirus

30G31, 35D41, 39451

4172 VPI AY543I55 4172 8582 12992, 17402, 21812, 26222, bovine enteric calicivirus

30632, 35042, 39452

4173 VPI AF320G25 4173 8583 12993, 17403, 21813, 26223, Norwalk-like virus

30B33, 35043, 39453

4174 VPI AY274820 4174 8584 12994, 17404, 21814, 26224, Norwalk-like virus

3D634, 35044, 39454

4175 VPI AF542083 4175 8585 12935, 17405, 21815, 2B225, bovine enteric calicivirus

30635, 35045, 33455

4I7B VPI E07343B7 4176 8586 12396. I740B, 21816, 26226, norovirus Bo/GIII/B3B9/2003/BEL

30636, 35046. 39456

4177 VPI AYI2B474 4177 8587 12997, 17407, 21817, 26227, Norwalk-like virus

30637, 35047, 39457

4178 VPI JXI45B50 4178 8588 12998, 17408, 21818, 26228, norovirus Gill

30638, 35048, 39458

4173 VPI AY549IBI 4173 8583 12999, 17409, 21819, 26229, bovine enteric calicivirus

30639, 35049, 39459

4180 VPI AY543IG4 4180 8590 13000, 17410. 21820, 26230, bovine enteric calicivirus

3064D, 35050, 39460

4181 VPI AYI2G47G 4181 8591 13001, 17411, 21821, 26231, Norwalk-like virus

30641, 35051, 39461

4182 VPI E0734305 4182 8592 13002, 17412, 21822, 26232. norovirus Bo/GIII/BVI5/2007/BEL

30642. 35052. 39462

4183 VPI E07343BG 4183 8593 13003, 17413, 21823, 26233, norovirus Bn/GIII/BV24/2007/BEL

30643, 35053, 39463 4184 VPi AYI26475 4184 8594 13004, 17414. 21824, 26234, Norwalk-Iike virus

30644, 35054, 39464

4185 VPI AF542D84 4185 8595 13005, 17415, 21825, 26235, bovine enteric calicivirus

30645, 35055, 39465

4186 VPI C695807 4186 8596 13006, 17416, 21826, 26236, norovirus

30646, 35056, 39466 Hu/GII.4/Sydney/NSW05l4/20l2/AO

4187 VP2 AGL984I5 4187 8597 13007, 17417, 21827, 26237, norovirus Hu/Gll/KL45/MY/I978

30647, 35057, 39467

4188 VP2 AGL984I7 4188 8598 13008, 17418, 21828, 26238, norovirus Hu/Gll/T09l/TN/I97G

30648, 35058, 39468

4188 VP2 AFI08232 4189 8599 13009, 17419. 21829, 26239, norovirus Hu/Gl/I0360/20IO/VNM

30649, 35059, 39469

4190 VP2 AFID8235 4190 86QQ 13010, 17420, 21830, 2624D, norovirus Hu/GII/10DD2/2D03/VNM

30650, 35060, 39470

4191 VP2 AFID8238 4191 8601 13011, 17421, 21831, 26241, norovirus Hu/GII/10003/2009/VNM

3DG51, 35061, 39471

4192 VP2 AFI0824I 4192 8G02 13012, 17422, 21832, 26242, norovirus Hu/GII/10012/2009/VNM

30652, 35062, 39472

4193 VP2 AFID8244 4193 8603 13013, 17423, 21833, 26243, norovirus Hu/GII/10037/2009/VNM

30653, 35063, 39473

4194 VP2 AFJ3852Q 4194 86D4 13014, 17424, 21834, 26244, norovirus Hu/Gll.4/CH0G519I/I974/0SA

30654, 35064, 39474

4195 VP2 AFX7I657 4195 8605 13015. 17425, 21835, 26245, norovirus Hu/Gll.3/H 7I/I978/CHN

30655, 35065, 39475

4196 VP2 AFX7I66D 4196 8606 13016, 17426, 21836, 26246, norovirus Hu/Gll.2/ LI03/I978/MYS

30656, 35066, 39476

4197 VP2 AFX7I666 4197 8607 13017, 17427, 21837, 26247, norovirus Hu/Gll.6/CHDC4073/I984/USA

30657, 35067, 39477

4198 VP2 AFX7IG69 4198 8608 13018, 17428, 21838. 26248, norovirus Hu/GII.4/NIHIC9/20II/USA

30658, 35068. 39478

4199 VP2 AFX8II22 4199 8609 13019, 17429, 21839, 26249, norovirus Hu/Norwalk/I0034/2D09/VNM

30659, 35069, 39479

42DQ VP2 AFX8II25 42GD 8610 13020, 17430, 21840, 26250, norovirus Hu/Norwalk/I005l/20D9/VNM

30660, 35070, 39480 42DI VP2 AFX8II3I 4201 8BII 13021, 17431, 21841, 2B25I, nnravirus Hu/Norwalk/IOOB2/2DDe/VNM

3DBBI, 35071, 39481

4202 VP2 AFX8II34 4202 8BI2 13022, 17432, 21842, 2B252, norovirus Hu/Norwalk/lDD74/2DQ9/VNM

30BB2, 35072, 39482

4203 VP2 AFX8II37 4203 8BI3 13023, 17433, 21843. 2B253, norovirus Hu/Norwalk/10075/2009/VNM

30BB3, 35073, 39483

42D4 VP2 AFX8II40 4204 8BI4 13024, 17434, 21844, 26254. norovirus Hu/Norwalk/10078/2009/VNM

30BB4, 35074.39484

4205 VP2 AFX8II43 4205 8BI5 13025. 17435, 21845, 2B255. norovirus Hu/Norwalk/I007B/2D09/VNM

30BB5, 35075, 39485

42DB VP2 AFX8II49 420B 8BIB I302B, I743B. 2I84B, 2B25B, norovirus Hu/Norwalk/IOII4/2DOe/VNM

30666, 35076.39486

4207 VP2 AFX8II52 4207 8BI7 13027, 17437, 21847, 26257, norovirus Hu/Norwalk/IOII6/200e/VNM

3D667, 35077, 39487

4208 VP2 AFX8II55 4208 8BI8 13028, 17438, 21848, 2B258, norovirus Hu/Nor alk/1DI29/2D09/VNM

306B8, 35078, 39488

4209 VP2 AFX8II58 4209 8BI9 13029, 17439, 21849, 26259. norovirus Hu/Norwalk/IOI3B/200B/VNM

306B9, 35079, 39489

4210 VP2 AFX8IIB4 4210 8B20 13030, 17440, 21850, 26260, norovirus Hu/Norwalk/10145/2009/VNM

30670, 3508D, 39490

4211 VP2 AFX8II73 4211 8B2I 13031, 17441. 21851, 2626!, norovirus Hu/Norwalk/10160/2009/VNM

30671, 35081, 39491

4212 VP2 AFX8II79 4212 8B22 13032, 17442, 21852, 262B2, norovirus Hu/Norwalk/10163/2009/VNM

30672, 35082, 39492

4213 VP2 AFX8II82 4213 8B23 13033, 17443. 21853. 262B3, norovirus Hu/Norwalk/10169/2009/VNM

30673, 35083, 39493

4214 VP2 AFX8II85 4214 8B24 13034, 17444. 21854, 26264. norovirus Hu/Norwalk/IOI73/20D9/VNM

30674, 35084, 39494

4215 VP2 AFX8II88 4215 8B25 13035, 17445, 21855. 262B5, norovirus Hu/Norwalk/IOI7B/20D9/VNM

30675.35085, 39495

42IB VP2 AFX8II9I 42IB 8B2B 13036, 17446, 21856. 262B6, norovirus Hu/Norwalk/10177/2009/VNM

30676, 3508B, 39496

4217 VP2 AFX8II94 4217 8B27 13037, 17447, 21857, 26267. norovirus Hu/Norwalk/IOI79/2009/VNM

30677, 35087, 39497 4218 VP2 AFX8II97 4218 8B28 I3D38, 17448. 21858, 2B2B8. norovirus Hu/Norwalk/10182/2009/VNM

3DB78, 35088, 39498

4219 VP2 AFX8I2DD 4219 8B29 13039, 17449, 21859, 2B2B9, norovirus Hu/Norwalk/IDiS3/2DD9/VNM

30B79, 35089, 39499

422D VP2 AFX8I203 422D 8B30 13040, 17450, 2I8B0, 2B270, norovirus Hu/Norwalk/IOI94/2QOO/VNM

30B80, 35090, 39500

4221 VP2 AFX8I20B 4221 8B3I 13041, 17451, 21861. 2B27I, norovirus Hu/Norwalk/IQI99/2009/VNM

30B81, 35091, 39501

4222 VP2 AFX8I2D9 4222 8B32 13042, 17452. 2I8B2, 2B272, norovirus Hu/Norwalk/I0203/2009/VNM

30B82, 35092, 39502

4223 VP2 AFX8I2I2 4223 8B33 13043, 17453, 2I8B3, 2B273, norovirus Hu/Norwalk/10204/2009/VNM

30B83, 35093, 39503

4224 VP2 AFX8I2I5 4224 8B34 I3D44. 17454, 2I8B4, 2B274, norovirus Hu/Norwalk/10222/2009/VNM

30B84, 35094, 39504

4225 VP2 AFX8I2I8 4225 8B35 13045, 17455, 2I8B5, 2B275, norovirus Hu/Norwalk/10223/2009/VNM

30B85, 35095, 39505

422B VP2 AFX8I22I 422B 8B3B I304B, I745B, 2I8BB, 2B27B, norovirus Hu/Norwalk/10235/2009/VNM

30B8B, 3509B, 3950B

4227 VP2 AFX8I224 4227 8B37 13047, 17457, 21867, 2B277, norovirus Hu/Norwalk/I023B/2009/VNM

30B87, 35097, 39507

4228 VP2 AFX8I227 4228 8B38 13048, 17458, 21868, 2B278, norovirus Hu/Norwalk/10238/2009/VNM

30688, 35098, 39508

4229 VP2 AFX8I230 4229 8B39 13049, 17459, 21869, 26279, norovirus Hu/Norwalk/I0247/2009/VNM

30689, 35099.39509

423D VP2 AFX8I233 4230 8B40 13050. 17460, 21870, 26280, norovirus Hu/Norwalk/10255/2000/VNM

30690, 35100, 39510

4231 VP2 AFX8I239 4231 8B4I 13051, 17461, 21871, 26281, norovirus Hu/Norwalk/I0296/20IO/VNM

30691, 35101, 39511

4232 VP2 AFX8I242 4232 8B42 13052, 17462, 21872, 26282, norovirus Hu/Norwalk/10313/2010/VNM

30692, 35102.39512

4233 VP2 AFX8I245 4233 8B43 13053, 17463, 21873, 26283, norovirus Hu/Norwalk/I0325/20IO/VNM

30693, 35103, 39513

4234 VP2 AFX8I248 4234 8B44 13054, 17464, 21874, 26284, norovirus Hu/Norwalk/10328/2010/VNM

30694, 35104, 39514 4235 VP2 AFX8I25I 4235 8645 13055, 17465, 21875, 26285, narovirus Hu/Narwalk/10368/2010/VNM

30695, 35105, 30515

4236 VP2 AFX81254 4236 8646 13056, 17466, 21876, 26286, noravirus Hu/Norwalk/I0378/201Q/VNM

30696. 35106, 39516

4237 VP2 AFX8I257 4237 8647 13057, 17467, 21877, 26287, narovirus Hu/Norwalk/I0386/2010/VNM

30697, 35107, 39517

4238 VP2 AFX8I26D 4238 8648 13058, 17468, 21878, 26288, norovirus Hu/Norwalk/20008/2009/VNM

30698, 35108, 39518

4239 VP2 AFX8I263 4239 8649 13059, 17469, 21879, 26289, norovirus Hu/Norwalk/20010/2009/VNM

30699, 35109, 39519

4240 VP2 AFX8I269 424D 865D 13060, 17470, 21880, 26290, narovirus Hu/Norwalk/200I6/2009/VNM

30700, 35110, 39520

4241 VP2 AFX8I272 4241 8651 13D6I, 17471, 21881, 26291, norovirus Hu/Norwalk/20019/2009/VNM

30701. 35111, 39521

4242 VP2 AFX81275 4242 8652 13062, 17472, 21882, 26292, noravirus Hu/Norwalk/2D033/20Q9/VNM

30702, 35112, 39522

4243 VP2 AFX8I278 4243 8653 13063, 17473, 21883, 26293, norovirus Hu/Narwalk/20035/2D09/VNM

30703. 35113, 39523

4244 VP2 AFX8I28I 4244 8654 13064, 17474, 21884, 26294, noravirus Hu/Norwalk/20044/2009/VNM

30704, 35114, 39524

4245 VP2 AFX8I284 4245 8655 13065, 17475, 21885, 26295, narovirus Hu/Norwalk/20047/2009/VNM

30705, 35115, 39525

4246 VP2 AFX8I287 4246 8656 13066, 17476, 21886. 26296, narovirus Hu/Norwalk/2006G/2009/VNM

30706, 35116, 39526

4247 VP2 AFX8I290 4247 8657 13067, 17477, 21887, 26297, norovirus Hu/Narwalk/20067/2009/VNM

30707, 35117, 39527

4248 VP2 AFX8I293 4248 8658 13068, 17478, 21888, 26298, noravirus Hu/Narwalk/20069/2009/VNM

30708, 35118, 39528

4249 VP2 AFX8I296 4249 8659 13069, 17479, 21889, 26299, norovirus Hu/Norwalk/20092/2009/VNM

30709, 35119, 39529

425D VP2 AFX8I299 425D 8660 13070, 17480, 21890, 26300, narovirus Hu/Narwalk/20093/2009/VNM

30710, 35120, 39530

4251 VP2 AFX8I3D2 4251 8661 13071, 17481, 21891, 26301, noravirus Hu/Narwalk/20094/2009/VNM

30711. 35121, 39531 4252 VP2 AFX8I305 4252 8G62 I3072, I7482, 2I832, 26302, norovirus Hu/Norwalk/20II8/2009/VNM

3G7I2, 35I22, 39532

4253 VP2 AFX8I3D8 4253 8663 I3D73. I7483. 2I893. 263D3, norovirus Hu/Norwalk/20I22/2009/VNM

3Q7I3, 35I23, 39533

4254 VP2 AFX8I3II 4254 8664 I3D74. I7484, 2I894, 263D4, norovirus Hu/Norwalk/20123/2009/VNM

3D7I4, 35I24.33534

4255 VP2 AFX8I3I4 4255 8665 I3Q75. I7485, 2I835, 26305, norovirus Hu/Norwalk/20I28/2009/VNM

307I5, 35I25, 39535

425G VP2 AFX8I3I7 425G 8666 I307G, I7486, 2I896, 26306, narovirus Hu/Nnrwalk/20135/2009/VNM

307I6, 35I26, 33536

4257 VP2 AFX8I320 4257 8667 I3077, I7487, 2I837, 26307, narovirus Hu/Narwalk/20l3B/2009/VNM

307I7, 35I27, 33537

4258 VP2 AFX8I323 4258 8668 I3078, 17488, 2I838, 26308, norDvirus Hu/Norwalk/20l40/20D9/VNM

30718, 35128, 33538

425B VP2 AFX8I32G 425B 8663 13073, 17483, 21833, 26303, noravirus Hu/Norwalk/20l42/2009/VNM

30713, 35123, 3B539

42G0 VP2 AGE89434 42GD 867Q 13080, 17430, 21300, 26310, norovirus Hu/GII/IOIOI/2009/VNM

30720, 35I3D, 39540

426I VP2 AGE89437 42GI 867I 13081, 17431, 21301, 26311, norovirus Hu/GII/10127/2009/VNM

30721, 35131, 33541

42G2 VP2 AGE8B44D 42G2 8672 13082, 17492, 21902, 26312. norovirus Hu/Gll/I0370/20I0/VNM

30722, 35132, 33542

4263 VP2 AGE89443 42G3 8673 13083, 17433. 21303, 26313, norovirus Hu/GII/10405/2010/VNM

3D723, 35133, 33543

42G4 VP2 AGE89449 4264 8674 13084, 17494, 21304, 2G3I4, norovirus Hu/BII/f D411/2010/VN

30724, 35134, 39544

4265 VP2 AGE89455 42G5 8675 13085, 17435, 21305, 2G3I5, norovirus Hu/GII/20048/2009/VNM

30725, 35135, 33545

42GG VP2 AGE89458 4266 8676 13086, 17436. 21306. 2G3I6. norovirus Hu/GII/2D064/2D09/VN

30726.35136, 33546

42G7 VP2 AGE8B4BI 4267 8677 13087, 17437, 21907, 26317, norovirus Hu/GII/20079/2009/VNM

30727, 35137, 39547

42G8 VP2 AGE834G4 4268 8678 13088, 17498, 21908, 2G3I8, norovirus Hu/GII/20107/2009/VNM

30728, 35138, 39548 4260 VP2 AGE89467 4269 8679 13089, I74B9. 21909, 26319, norovirus Hu/GII/20108/2009/VNM

30729, 35139, 39549

427D VP2 AGE8947D 427D 8680 13090, 17500, 21910, 26320, norovirus Hu/GII/20144/2009/VNM

30730, 35140, 39550

4271 VP2 AGE89473 4271 8681 13091, 17501, 21911. 26321, norovirus Hu/GII/20146/2009/VNM

30731, 35141, 39551

4272 VP2 AGE89476 4272 8682 13092, 17502, 21912. 26322, norovirus Hu/GII/20150/2009/VNM

30732, 35142, 39552

4273 VP2 AGE89479 4273 8683 13093, 17503, 21913, 26323, norovirus Hu/GII/20151/2009/VNM

30733, 35143, 39553

4274 VP2 AGE89482 4274 8684 13094, 17504, 21914, 26324, norovirus Hu/Gll/20153/2009/VNM

30734, 35144, 39554

4275 VP2 AGE89485 4275 8B85 13095, 17505, 21915, 26325, norovirus Hu/GII/20154/2009/VNM

30735, 35145, 39555

4276 VP2 AGE89488 4276 8686 13096, 17506, 21916, 26326, norovirus Hu/GII/20156/2009/VNM

30736, 35146, 39556

4277 VP2 AGE8949I 4277 8687 13097, 17507, 21917, 26327, norovirus Hu/GII/20159/2009/VNM

30737, 35147, 30557

4278 VP2 AGE89494 4278 8688 13098, 17508, 21918. 26328, norovirus Hu/GII/20161/2009/VNM

30738, 35148, 39558

4279 VP2 AGE89497 4279 8689 13099, 17509, 21919, 26329, norovirus Hu/Gll/20I62/2D09/VNM

30739.35149.39559

4280 VP2 AGE895DD 4280 8690 13100. 17510, 21920, 26330, norovirus Hu/GII/20164/2009/VNM

30740, 35150, 39560

4281 VP2 AGE895D3 4281 8691 13101, 17511. 21921, 26331, norovirus Hu/GII/20171/2009/VNM

30741, 35151, 39561

4282 VP2 AGE895D6 4282 8692 13102, 17512, 21922, 26332, norovirus Hu/GII/20172/2009/VNM

30742, 35152, 39562

4283 VP2 AGE89509 4283 8693 13103, 17513, 21923. 26333, norovirus Hu/GII/20173/2009/VNM

30743, 35153, 39563

4284 VP2 AGE895I2 4Z84 8694 13104, 17514, 21924. 26334, norovirus Hu/GII/20176/2009/VNM

30744, 35154, 39564

4285 VP2 AGE895I5 4285 8695 13105, 17515, 21925, 26335, norovirus Hu/GII/20180/2009/VNM

30745.35155.39565 428G VP2 AGE895I8 428B 8B9B 13106. I75IB, 2I92B, 2B33B, norovirus Hu/GII/20182/2009/VNM

3074B, 35156. 39566

4287 VP2 AGE8952! 4287 8B97 13107, 17517, 21927, 2B337, norovirus Hu/GII/20184/2009/VNM

30747, 35157, 395B7

4288 VP2 AGE89524 4288 8B98 13108, 17518. 21928, 26338, norovirus Hu/GII/20185/2009/VNM

30748. 35158, 39568

4289 VP2 AGE89530 4289 8B99 13109. 17519, 21929, 26339, norovirus Hu/GII/20189/2009/VNM

30749, 35159, 395B9

4290 VP2 AGE89533 4230 8700 13110. 17520, 21930, 26340, norovirus Hu/GII/20190/2009/VNM

30750, 35160, 39570

4291 VP2 AGE89536 4291 8701 13111, 17521, 21931, 2B34I, norovirus Hu/GII/20192/2009/VNM

30751, 35161, 39571

4292 VP2 AGE89539 4292 8702 13112, 17522, 21932, 26342, norovirus Hu/GII/20196/2009/VNM

3D752, 35IB2, 39572

4293 VP2 AGE89542 4293 8703 13113, 17523, 21933, 26343, norovirus Hu/GII/20198/2009/VNM

30753, 35IB3, 39573

4294 VP2 AGE89545 4294 8704 13114. 17524, 21934, 26344, norovirus Hu/GII/20202/2009/VNM

30754, 35IB4, 39574

4295 VP2 AGE89548 4295 8705 13115. 17525, 21935, 2B345, norovirus Hu/GII/20205/2009/VNM

30755, 35IB5, 39575

429B VP2 AGE8955I 429B 870B 13116, I752B, 2I93B, 26346, norovirus Hu/Gll/2020G/2009/VNM

30756, 35166, 39576

4297 VP2 AGE89554 4297 8707 13117, 17527, 21937, 2B347, norovirus Hu/GII/20208/2009/VNM

30757, 35IB7, 33577

4298 VP2 AGE89557 4298 8708 13118. 17528. 21338, 2B348, norovirus Hu/Gll/202I5/20Q9/VNM

30758, 35168, 33578

4299 VP2 AGE895B0 4299 8709 13119, 17529, 21939, 2B349, norovirus Hu/GII/20217/2009/VNM

30759.35169, 39579

430D VP2 AGE895B3 4300 8710 13120, 17530, 21940, 26350, norovirus Hu/GII/20229/2009/VNM

30760, 35170, 3B580

4301 VP2 AGE895BB 4301 8711 13121. 17531, 21941, 2B35I, norovirus Hu/GII/20230/2009/VNM

307BI, 35171, 39581

4302 VP2 AGE895B9 4302 8712 13122, 17532, 21942, 2B352, norovirus Hu/GII/20233/2009/VNM

307B2, 35172, 39582 4303 VP2 AGE89572 4303 8713 13123. 17533, 21943. 26353, norovirus Hu/GII/20248/2009/VNM

30763. 35173. 39583

43D4 VP2 AGE89578 4304 8714 13124, 17534, 21944, 26354, norovirus Hu/Gli/20263/2009/VNM

30764, 35174, 39584

43D5 VP2 AGE8958I 4305 8715 13125, 17535, 21945, 26355, norovirus Hu/GII/2027l/2009/VNM

30765, 35175.39585

4306 VP2 AGE89587 4306 8716 13126, 17536, 21946, 26356, norovirus Hu/GII/20302/2009/VNM

30766, 35176. 39586

4307 VP2 AGE89590 4307 8717 13127. 17537, 21947, 26357, norovirus Hu/GII/20344/2009/VNM

30767, 35177, 39587

4308 VP2 AGE89593 4308 8718 13128, 17538, 21948, 26358, norovirus Hu/GII/20350/2D09/VNM

30768, 35178, 39588

4309 VP2 AGE89596 4309 8719 13129, 17539, 21949, 26359, norovirus Hu/GII/20357/2009/VNM

30769, 35179, 39589

4310 VP2 AGE89599 4310 8720 13130. 17540, 21950, 26360, norovirus Hu/GII/20365/20ID/VNM

30770, 35180, 39590

4311 VP2 AGE89602 4311 8721 13131. 17541, 21951, 26361, norovirus Hu/GII/20373/2DI0/VNM

30771, 35181, 39591

4312 VP2 AGE89605 4312 8722 13132, 17542, 21952, 26362, norovirus Hu/GII/20407/2010/VNM

30772, 35182, 39592

4313 VP2 AGE896D8 4313 8723 13133, 17543, 21953, 26363, norovirus Hu/Gl!/2D4f 3/2DI0/VNM

30773, 35183, 39593

4314 VP2 AGE896II 4314 8724 13134. 17544, 21954, 26364, norovirus Hu/GII/20424/2010/VNM

30774, 35184, 39594

4315 VP2 AGE896I4 4315 8725 13135, 17545, 21955, 26365, norovirus Hu/GII/20448/2010/VNM

30775, 35185, 39595

4316 VP2 AGE896I7 4316 8726 13136, 17546, 21956, 26366, norovirus Hu/GII/20457/2010/VNM

30776, 35186, 39596

4317 VP2 AGE89620 4317 8727 13137, 17547, 21957, 26367, norovirus Hu/GII/20460/2010/VNM

30777, 35187, 39597

4318 VP2 AGE8B623 4318 8728 13138, 17548, 21958, 2B368, norovirus Hu/GII/20469/2010/VNM

30778, 35188, 39598

4319 VP2 AGE89626 4319 8729 13139, 17549, 21959, 26360, norovirus Hu/GII/20477/2010/VNM

30779, 35180, 39599 4320 VP2 ABE89G29 432D 8730 13140, 17550, 2I9BD, 2B370, norovirus Hu/GII/20478/2010/VNM

30780, 35190, 39B00

4321 VP2 AGE89B35 4321 8731 13141, 17551, 21961, 2B37I, norovirus Hu/GII/30026/2009/VNM

30781, 35191, 39B0I

4322 VP2 AGE89G38 4322 8732 13142, 17552, 21962, 2B372, norovirus Hu/GII/30040/2009/VNM

30782, 35192, 39B02

4323 VP2 AGE89B4I 4323 8733 13143, 17553, 2I9B3, 2B373, norovirus Hu/GII/30045/2009/VNM

30783, 35103, 39B03

4324 VP2 AGE89644 4324 8734 13144, 17554, 2I9B4, 2B374, norovirus Hu/GII/30112/2009/VNM

30784, 35194, 39B04

4325 VP2 AGE89647 4325 8735 13145, 17555, 219B5, 2B375, norovirus Hu/GII/30113/2009/VNM

30785, 35195, 39605

432B VP2 AGE8965D 432B 873B 13146, 17556, 21966, 26376, norovirus Hu/GII/30129/2009/VNM

30786, 35196, 39606

4327 VP2 AGE89653 4327 8737 13147, 17557, 21967, 26377, norovirus Hu/GII/30199/2009/VNM

30787, 35197, 39B07

4328 VP2 AGE89G5B 4328 8738 13148, 17558, 21968. 26378, norovirus Hu/GII/3020l/2009/VNM

30788, 35198, 39608

4329 VP2 AGE89B59 4329 8739 13149, 17559, 21960, 26379, norovirus Hu/GII/30206/2009/VNM

30780, 35199, 39609

433D VP2 AGE89B62 433G 8740 13150, 17560, 21970, 26380, norovirus Hu/GII/30207/2009/VNM

30790, 35200, 39610

4331 VP2 AGE89B65 4331 8741 13151, 17561, 21971, 26381, norovirus Hu/GII/302ll/2009/VNM

30791, 35201, 39611

4332 VP2 AGE89GG8 4332 8742 13152, 17562, 21972, 26382, norovirus Hu/GII/30212/2009/VNM

30792, 35202, 39612

4333 VP2 AGE89B7I 4333 8743 13153, 17563, 21973, 26383, norovirus Hu/GII/30257/2009/VN

30793, 35203, 39GI3

4334 VP2 AGE89G74 4334 8744 13154, I75B4, 2IB74, 26384, norovirus Hu/GII/302G6/2009/VNM

30794, 35204, 39614

4335 VP2 AGE99BQ4 4335 8745 13155, I75B5, 21975, 26385, norovirus Hu/GII.4/NIHIC4.l/20ll/USA

30795, 35205, 39GI5

433B VP2 AGE99GD7 433B 874B 13156. I75B6, 21976, 26386, norovirus Hu/GII.4/CII0/l978/GUF

30796, 35206, 396IB 4337 VP2 AGK363I2 4337 8747 13157, 17567, 21977, 2B387, norovirus Hu/Gll.4/20I99/2009/VNM

30797, 35207, 39GI7

4338 VP2 AGK3B3I5 4338 8748 13158, I75B8, 21978, 2B388, norovirus Hu/GII.4/2040B/20IO/VN

30798, 35208, 39BI8

4339 VP2 AGM332Q9 4339 8749 13159, I75B9, 21979, 2B389, norovirus Hu/GI.I/CHA7A009/2OIO/0SA

3D799, 35209, 39619

4340 VP2 AGM332I5 4340 8750 13160. 17570, 21980, 26390, norovirus

3D800, 35210, 39B2D Hu/GI.I/CHA6AD03_2DD9ID2B/20D3/USA

4341 VP2 AGM332I8 4341 8751 13161, 17571, 21981, 2B39I, norovirus Hu/GI.I/CHA2AOI4/2008/USA

30801, 35211, 39B2I

4342 VP2 AGM3322I 4342 8752 13162. 17572, 21982, 2B392, norovirus Hu/GI.I/CHA6A007/2DI0/0SA

30802, 35212, 39622

4343 VP2 AGM33224 4343 8753 13163. 17573, 21983, 26393, norovirus

30803, 35213, 39623 Hu/Gl.l/CHA9A004_20II04I9/20II/0SA

4344 VP2 AGM33227 4344 8754 13164. 17574, 21984, 2B394, norovirus Hu/Gl.i/CH4X0533/2009/USA

30804, 35214, 39624

4345 VP2 AGM3323D 4345 8755 13165. 17575, 21985, 26395, norovirus Hu/GI.I/CHA5AOIO/2009/OSA

30805, 35215, 39625

434B VP2 AGM33233 434B 875B 13166, 17576, 21986, 26396, norovirus

30806, 35216. 39626 Hu/GI.I/CHA9AD04_20il042B/20ll/0SA

4347 VP2 AGM3323B 4347 8757 13167. 17577, 21987, 2B397, norovirus Hu/Gl.l/CHA6A0I4/20D9/0SA

30807, 35217, 39627

4348 VP2 AGM33239 4348 8758 13168, 17578, 21988, 2G398, norovirus Hu/GI.I/CHA3A007/20D8/USA

30808, 35218, 39628

4349 VP2 AGM33242 4349 8759 13169, 17579, 21989, 26399, norovirus Hu/GI.I/CHA7A0ll/20IO/OSA

30809, 35219, 39629

435D VP2 AGM33245 4350 87BD 13170. I758D, 21990. 26400, norovirus

30810, 35220, 39630 Hu/Gl.l/CHABA003_2009II04/2009/USA

4351 VP2 AGTI778G 4351 87BI 13171, 17581, 21991, 26401, norovirus Hu/GU/8MolllL/l972/USA

30811, 35221.39631

4352 VP2 AGTI7793 4352 87B2 13172, 17582, 21992, 2B402, norovirus Hu/Gl.l/8W/I9G8/USA

30812, 35222, 39B32

4353 VP2 AGT1779B 4353 87B3 13173, 17583, 21993, 2B403, norovirus Hu/GII.4/NIHICI3/20ll/USA

30813, 35223, 39633 4354 VP2 AGTI7799 4354 8764 13174. 17584. 21994, 26404. nDrovirus Hu/GII.4/NIHICI.I3/2DIZ/USA

30814, 35224, 39634

4355 VP2 AGTI7804 4355 8765 13175, 17585. 21995, 26405, narovirus Hu/GI.I/8Mclll/IS73/USA

30815, 35225, 39635

435G VP2 AGTI78Q7 4356 8766 13176, 17586, 21096, 26406, norovirus Hu/GI.I/BC IIIc/1974/USA

30816, 35226, 39636

4357 VP2 AGTI78I0 4357 8767 13177, 17587, 21997, 26407, norovirus Hu/GI.I/8Ulllf/l973/USA

30817, 35227, 39637

4358 VP2 AGTI78I4 4358 8768 13178, 17588, 21998, 26408, norovirus Hu/Gll,4/NIHICI7.I/20I2/USA

30818, 35228, 39638

4359 VP2 AGTI7820 4359 8769 13179, 17589, 21999, 26409, norovirus Hu/GII.4/NIHICf8.f/20l2/USA

30819, 35229, 39639

43GD VP2 AGTI7824 4360 8770 13180, 17590, 22000, 26410, narovirus Hu/GII.4/NIHICI.3/2DID/USA

30820, 35230, 39640

43GI VP2 AGTI7827 4361 8771 13181. 17591, 22001, 26411, narovirus Hu/Gl.l/8K/I979/USA

30821, 35231, 39641

4362 VP2 AGTI783I 4362 8772 13182, 17592, 22002, 26412, narovirus Hu/Gll.4/NIHIC28.5/20I2/USA

30822, 35232, 39642

43B3 VP2 AGTI7837 4363 8773 13183, 17593, 22003. 26413, norovirus Hu/Gl.l/8MC/I978/USA

30823, 35233, 39643

43G4 VP2 AGTI7843 4364 8774 13184. 17594, 22004, 26414, narovirus Hu/GII.4/NIHICI.5/ZDII/USA

30824, 35234, 39644

4365 VP2 AGX85887 4365 8775 13185, 17595, 22005, 26415, norovirus Hu/Gll.4/NIHICI7.8/20I3/0SA

30825, 35235, 39645

4366 VP2 AGX85893 4366 8776 13186, 17596, 22006, 26416, narovirus Hu/Gll,4/NIHICIJ0/20I2/USA

30826, 35236, 39646

4367 VP2 AGX85896 4367 8777 13187, 17597, 22007, 26417, norovirus Hu/Gll.4/NIHICI.7/20I2/USA

30827, 35237, 39647

4368 VP2 AGX85905 4368 8778 13188, 17598, 22008, 26418, norovirus Hu/Gll.4/NIHIC27.2/20I2/USA

30828, 35238, 39648

4369 VP2 AGX859I4 4369 8779 13189, 17599. 22009, 26419, norovirus Hu/GII.4/NIHICI.I4/2DI2/USA

30829, 35239, 39649

4370 VP2 AGX859I7 4370 8780 13190, 17600. 22010. 26420, narovirus Hu/Gll.4/NIHICI7.B/20I2/USA

30830, 35240, 39650 4371 VP2 AGX85923 4371 8781 13191. I7B0I, 22011, 2B42I. norovirus Hu/Gll.4/NIHIC28.3/20I2/USA

30831, 35241, 39B5I

4372 VP2 AGX8592B 4372 8782 13192, I7B02, 22012, 2B422, norovirus Hu/Gll.4/NIHICII.3/20I3/USA

3D832, 35242, 39652

4373 VP2 AGX85932 4373 8783 13193, I7B03, 22013, 2B423. norovirus Hu/Gll.4/NIHICI.I2/20I2/0SA

30833, 35243, 39B53

4374 VP2 AGX85935 4374 8784 13194, I7B04, 22014, 2B424, norovirus Hu/Gll.4/N!HICI.II/20I2/USA

30834, 35244, 39B54

4375 VP2 AHI59I55 4375 8785 13195, I7B05, 22015, 2B425, norovirus Hu/GII.6/HS245/20IO/USA

30835, 35245, 39B55

437B VP2 AHI59I58 437B 878B I3I9B, I7B0B, 220IB, 2B42B, norovirus Hu/GII.4/HSZ3Z/20l2/USA

3083B, 3524B, 39B5B

4377 VP2 AHI59IB0 4377 8787 13197, I7BD7. 22017, 2B427. norovirus Hu/GII.2/HS255/20ll/USA

30837, 35247.39B57

4378 VP2 AHI59IB3 4378 8788 13198, I7B08, 22018, 2B428, norovirus Hu/GII.4/HS288/20l2/0SA

30838, 35248, 39658

4379 VP2 AHI59IBB 4379 8789 13199, 17609, 22019, 26429, norovirus Hu/GII.4/HS66/200l/USA

30839, 35249, 39659

438D VP2 AHX22D2B 4380 8790 13200, 17610, 22020, 26430. norovirus Hu/GII/BGIC0Z82/20ll/BGD

30840, 35250, 39660

4381 VP2 AHX22D29 4381 8791 13201, I7BII, 22021, 2B43I, norovirus Hu/GII/BGIC039l/Z0IZ/BGD

30841, 35251, 39661

4382 VP2 AHX22D33 4382 8792 13202, 17612, 22022, 26432, norovirus Hu/Gll/BGIG00BG/Z0ll/BBD

30842, 35252, 396B2

4383 VP2 AHX22D3B 4383 8793 13203. 17613, 22023, 26433, norovirus Hu/GII/BGIC024l-3Z/20ll/BGD

30843, 35253, 396B3

4384 VP2 AHX22D39 4384 8794 13204. 17614. 22024, 2B434, norovirus Hu/Gll/BGIC0398/20I2/BGD

30844, 35254, 39B64

4385 VP2 AHX22D42 4385 8795 13205, 17615, 22025, 2B435, norovirus Hu/Gll/BGIC0405/20I2/BG0

30845, 35255, 39B65

4386 VP2 AHX22D48 438B 879B 13206. 17616, 2202B, 2B436, norovirus Hu/GII/BGIC0004/20ID/BG0

3084B, 35256, 30666

4387 VP2 AHX22D5I 4387 8797 13207, 17617, 22027, 2B437, norovirus Hu/GII/BGIC024l-33/20ll/BGD

30847, 35257, 39BB7 4388 VP2 AHX22D55 4388 8798 13208, 17618. 22028, 2B438, norovirus Hu/GII/BGIC0270/20ll/BGD

30848, 35258, 39BB8

4389 VP2 AII02849 4389 8799 13209, I7BI9, 22029, 26439, norovirus Hu/GII/C2H-45/20ll/VNM

30849, 35259, 30669

4390 VP2 AKE07I0I 4390 8800 13210, 17620, 22030, 26440, norovirus Gil

30850, 35260, 39670

4391 VP2 AKE07I04 4391 8801 13211, 17621, 22031, 26441, norovirus Gil

30851, 35261, 39671

4392 VP2 AKE07I07 4392 8802 13212, 17622, 22032, 2B442, norovirus Gil

30852, 35262, 39672

4393 VP2 ALE30B34 4393 8803 13213, 17623, 22033, 26443, norovirus Gil

30853, 35263, 39673

4394 VP2 ALE30B3B 4394 8804 13214, I7B24, 22034, 2B444, norovirus Gil

30854, 35264, 39B74

4395 VP2 BAR42290 4395 8805 13215, 17625, 22035, 26445, norovirus

30855, 35265, 39675 Hu/GII/JP/20l5/GII,PI7_GIIJ7/ awasaki308

439B VP2 BAR47BI7 4396 880B 13216, 17626, 22036, 2B44B, norovirus

30856, 3526B, 39B76 Hu/GII/JP/2DI4/GII.PI7_GII.I7/Nagano7-l

4397 VP2 BARB37IB 4397 8807 13217, 17627, 22037, 2B447, norovirus

30857. 352B7, 39677 Hu/GII/JP/20l3/GII.PI7_GII.I7/Saitama5203

4398 VP2 BARB37I9 4398 8808 13218, 17628. 22038, 26448, norovirus

3D858, 35268, 39678 Hu/GII/JP/20l3/GII.PI7_GII.I7/Saitama5309

4399 VP2 BARB3722 4390 8809 13219, 17629, 22039, 26449, norovirus

30859, 35269, 39679 Hu/GII/JP/20l4/GII.PI7_GII.I7/Nagano8-l

44D0 VP2 BASD2084 4400 8810 13220, 17630, 22040, 26450, norovirus

30860, 35270, 39680 Hu/GII/JP/20l5/GII.Pe_GII.4/0saka/0SF78

4401 VP2 CRL4B953 4401 8811 13221, 17631, 22041, 26451, norovirus GI/Hu/NL/20ll/GI.4/Groningen

30861, 35271, 39681

4402 VP2 CRL46956 4402 8812 13222, 17632, 22042, 26452, norovirus GI/Hu/NL/20l2/GI.6/GroningBn

30862, 35272, 39682

4403 VP2 CRL46959 4403 8813 13223, 17B33, 22043, 26453, norovirus GII/Hu/NL/20l2/GII.4/GroningBn

30863, 35273, 39683

44D4 VP2 CRL4B9B2 4404 8814 13224, I7B34, 22044, 26454, norovirus Gll/Hu/NL/20I4/Gll.4/Groningen0l

30864, 35274, 39684 44D5 VP2 CRL4G965 4405 8815 13225, I7G35, 22045. 2G455. noPDvipus BII/Hu/NL/ZOI4/GII.4/GrDningBnD2

308G5, 35275, 39G85

44DB VP2 CRL46968 440G 88IG I322G, I7G3G. 22046, 2645G, norovirus Gll/Hu/NL/20I4/Gll.6/Groningen

308GG, 3527G, 39G8G

4407 VP2 CRL4B37I 4407 8817 13227. I7G37, 22047, 2G457, narovirus Gtl/Hu/NL/2014/GII.21/Graningen

308G7, 35277, 39G87

4408 VP2 CRL46974 4408 8818 13228, 17638, 22048, 2G458, norovirus Gll/Hu/NL/20I4/Gll.2/Groningen

30868, 35278. 39688

4409 VP2 CRL4G977 4409 8819 13229, 17639, 22049, 26459, narovirus Gll/Hu/NL/2Dt2/GII.4/NijmegenDI

30869, 5279, 39689

4410 VP2 CRL4G980 4410 8820 13230, 17G40, 22050, 2G460. norovirus GII/Hu/NL/20l2/Gli.4/NijmegBn02

30870. 35280. 39690

Legend to Table I: Column I: protein name (according to NCBf or Genbank entry); Column 2: NCBI or Genbank Accession No.; Column 3 ("A"): SEQ ID NOs of amino acid sequence; Column 4 ("B"): SEQ 10 NOs of wild type coding sequences; Column 5 ("C"): SEQ ID NOs of optimized ending sequence.