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Title:
NUCLEIC ACID MOLECULES WITH SPECIFIC IDENTIFICATION OF NATIVE PRP, THEIR PRODUCTION AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO2000073501
Kind Code:
A3
Abstract:
The invention relates to a method for isolating nucleic acid molecules which are capable of specific interaction with native PrP and can differentiate between native PrP and native PrP. The inventive method comprises the following steps: incubating a pool of nucleic acids with purified PrP preparations (PPPs); selecting and isolating the resulting protein/nucleic acid complexes and optionally amplifying the specific nucleic acids, in addition to optionally repeating the incubation and isolation stage. The invention also relates to the nucleic acid molecule produced by this method and the use thereof for diagnosing and treating transmissible spongiform encephalopathies.

Inventors:
WEISS STEFAN (DE)
Application Number:
PCT/EP2000/005020
Publication Date:
March 08, 2001
Filing Date:
May 31, 2000
Export Citation:
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Assignee:
LASMEZAS CORINNE IDA (FR)
WEISS STEFAN (DE)
International Classes:
A61K31/7088; A61P25/00; C12N15/09; G01N33/50; C12P19/34; C12Q1/68; C12Q1/6888; G01N33/566; G01N33/569; (IPC1-7): C12Q1/68; C12Q1/70; G01N33/68
Domestic Patent References:
WO1997015685A11997-05-01
WO1997010505A11997-03-20
WO1998035236A21998-08-13
WO1998053838A21998-12-03
Other References:
WEISS STEFAN ET AL: "RNA aptamers specifically interact with the prion protein PrP.", JOURNAL OF VIROLOGY, vol. 71, no. 11, 1997, pages 8790 - 8797, XP002152780, ISSN: 0022-538X
KORTH C ET AL: "PRION (PRPSC)-SPECIFIC EPITOPE DEFINED BY A MONOCLONAL ANTIBODY", NATURE,GB,MACMILLAN JOURNALS LTD. LONDON, vol. 390, no. 6655, 6 November 1997 (1997-11-06), pages 74 - 77, XP002069611, ISSN: 0028-0836
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