Title:
NUCLEIC ACID SEQUENCE DETECTION
Document Type and Number:
WIPO Patent Application WO2004046369
Kind Code:
A3
Abstract:
The present application discloses a system and a method for detecting a target nucleic acid sequence using a support 104 comprising an electrode 22 with a nucleic acid probe 24 attached thereto. A nucleic acid target 26 and a non-covalent photoelectrochemical label 30 are contacted with the probe 24. The photoelectrochemical intercalator 30 preferentially binds double-stranded nucleic acids. Irradiating the mixture generates a photocurrent at the electrode 22. Also disclosed is a support 104 comprising an array of nucleic acid probe elements.
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Inventors:
LIU TIMOTHY Z
BEAVERS SCOTT
BI WANLI
BEAVERS SCOTT
BI WANLI
Application Number:
PCT/US2003/036197
Publication Date:
December 09, 2004
Filing Date:
November 14, 2003
Export Citation:
Assignee:
APPLERA CORP (US)
International Classes:
C12M1/34; C12Q1/68; G01N27/30; C12Q; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO1999067628A1 | 1999-12-29 |
Foreign References:
| US6264825B1 | 2001-07-24 | |||
| US6288221B1 | 2001-09-11 | |||
| US5770369A | 1998-06-23 |
Other References:
OZKAN D. ET AL: "DNA and PNA sensing on mercury and carbon electrodes by using methylene blue as an electrochemical label", BIOELECTROCHEMISTRY, vol. 58, 2002, pages 119 - 126, XP002981297
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