Title:
NUCLEIC ACID STRUCTURE CONTAINING A PYRIPYROPENE BIOSYNTHESIS GENE CLUSTER AND A MARKER GENE
Document Type and Number:
WIPO Patent Application WO/2011/093186
Kind Code:
A1
Abstract:
Provided is a nucleic acid structure containing a pyripyropene biosynthesis gene cluster and a marker gene. Said nucleic acid structure allows pyripyropenes to be manufactured inexpensively with high productivity.
Inventors:
AIHARA SATO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
Application Number:
PCT/JP2011/050852
Publication Date:
August 04, 2011
Filing Date:
January 19, 2011
Export Citation:
Assignee:
MEIJI SEIKA KAISHA (JP)
AIHARA SATO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
AIHARA SATO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
International Classes:
C12N15/09; C12N1/15; C12P17/18
Domestic Patent References:
WO2010010955A1 | 2010-01-28 | |||
WO2004060065A1 | 2004-07-22 | |||
WO2006129714A1 | 2006-12-07 |
Foreign References:
JPH06184158A | 1994-07-05 | |||
JPH04360895A | 1992-12-14 | |||
JP3961289B2 | 2007-08-22 | |||
JPH0358566B2 | 1991-09-05 | |||
JP3593134B2 | 2004-11-24 |
Other References:
FEDOROVA N.D. ET AL: "Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus", PLOS GENET., vol. 4, no. 4, 2008, pages E1000046, XP002519164
NIERMAN W.C. ET AL: "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus", NATURE, vol. 438, no. 7071, 2005, pages 1151 - 1156, XP008139207
TOMODA H. ET AL.: "Biosynthesis of Pyripyropene A", J. ORG. CHEM., vol. 61, no. 3, 1996, pages 882 - 886, XP008139912
SUNAZUKA T. ET AL.: "Total synthesis of alpha-pyrone meroterpenoids, novel bioacti ve microbial metabolites", CHEM. REV., vol. 105, no. 12, 2005, pages 4559 - 4580, XP008139913
GO TSUJIUCHI ET AL.: "Pyripyropene-rui Seisanno o Yusuru Shinki Biseibutsu", JAPAN INSTITUTE OF INVENTION AND INNOVATION, JOURNAL OF TECHNICAL DISCLOSURE, JOURNAL NUMBER 2008-500997, 13 February 2008 (2008-02-13), XP009154054
JOURNAL OF ANTIBIOTICS, vol. 49, no. 3, 1996, pages 292 - 298
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 12, 1995, pages 4429 - 4435
BIERMAN, M. ET AL., GENE, vol. 116, 1992, pages 43 - 49
MYCOLOGY, vol. 49, 2004, pages 84 - 85
See also references of EP 2530149A4
NIERMAN W.C. ET AL: "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus", NATURE, vol. 438, no. 7071, 2005, pages 1151 - 1156, XP008139207
TOMODA H. ET AL.: "Biosynthesis of Pyripyropene A", J. ORG. CHEM., vol. 61, no. 3, 1996, pages 882 - 886, XP008139912
SUNAZUKA T. ET AL.: "Total synthesis of alpha-pyrone meroterpenoids, novel bioacti ve microbial metabolites", CHEM. REV., vol. 105, no. 12, 2005, pages 4559 - 4580, XP008139913
GO TSUJIUCHI ET AL.: "Pyripyropene-rui Seisanno o Yusuru Shinki Biseibutsu", JAPAN INSTITUTE OF INVENTION AND INNOVATION, JOURNAL OF TECHNICAL DISCLOSURE, JOURNAL NUMBER 2008-500997, 13 February 2008 (2008-02-13), XP009154054
JOURNAL OF ANTIBIOTICS, vol. 49, no. 3, 1996, pages 292 - 298
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 12, 1995, pages 4429 - 4435
BIERMAN, M. ET AL., GENE, vol. 116, 1992, pages 43 - 49
MYCOLOGY, vol. 49, 2004, pages 84 - 85
See also references of EP 2530149A4
Attorney, Agent or Firm:
KATSUNUMA Hirohito et al. (JP)
Katsunuma Hirohito (JP)
Katsunuma Hirohito (JP)
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