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Title:
NUCLEIC ACID STRUCTURE CONTAINING A PYRIPYROPENE BIOSYNTHESIS GENE CLUSTER AND A MARKER GENE
Document Type and Number:
WIPO Patent Application WO/2011/093186
Kind Code:
A1
Abstract:
Provided is a nucleic acid structure containing a pyripyropene biosynthesis gene cluster and a marker gene. Said nucleic acid structure allows pyripyropenes to be manufactured inexpensively with high productivity.

Inventors:
AIHARA SATO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
Application Number:
PCT/JP2011/050852
Publication Date:
August 04, 2011
Filing Date:
January 19, 2011
Export Citation:
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Assignee:
MEIJI SEIKA KAISHA (JP)
AIHARA SATO (JP)
SUMIDA NAOMI (JP)
MURASHIMA KOICHIRO (JP)
YANAI KOUJI (JP)
ANZAI HIROYUKI (JP)
YAMAMOTO KENTARO (JP)
International Classes:
C12N15/09; C12N1/15; C12P17/18
Domestic Patent References:
WO2010010955A12010-01-28
WO2004060065A12004-07-22
WO2006129714A12006-12-07
Foreign References:
JPH06184158A1994-07-05
JPH04360895A1992-12-14
JP3961289B22007-08-22
JPH0358566B21991-09-05
JP3593134B22004-11-24
Other References:
FEDOROVA N.D. ET AL: "Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus", PLOS GENET., vol. 4, no. 4, 2008, pages E1000046, XP002519164
NIERMAN W.C. ET AL: "Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus", NATURE, vol. 438, no. 7071, 2005, pages 1151 - 1156, XP008139207
TOMODA H. ET AL.: "Biosynthesis of Pyripyropene A", J. ORG. CHEM., vol. 61, no. 3, 1996, pages 882 - 886, XP008139912
SUNAZUKA T. ET AL.: "Total synthesis of alpha-pyrone meroterpenoids, novel bioacti ve microbial metabolites", CHEM. REV., vol. 105, no. 12, 2005, pages 4559 - 4580, XP008139913
GO TSUJIUCHI ET AL.: "Pyripyropene-rui Seisanno o Yusuru Shinki Biseibutsu", JAPAN INSTITUTE OF INVENTION AND INNOVATION, JOURNAL OF TECHNICAL DISCLOSURE, JOURNAL NUMBER 2008-500997, 13 February 2008 (2008-02-13), XP009154054
JOURNAL OF ANTIBIOTICS, vol. 49, no. 3, 1996, pages 292 - 298
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 61, no. 12, 1995, pages 4429 - 4435
BIERMAN, M. ET AL., GENE, vol. 116, 1992, pages 43 - 49
MYCOLOGY, vol. 49, 2004, pages 84 - 85
See also references of EP 2530149A4
Attorney, Agent or Firm:
KATSUNUMA Hirohito et al. (JP)
Katsunuma Hirohito (JP)
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Claims: