Title:
NUCLEIC ACID TRANSPORTER CONTAINING POLYPEPTIDE AND RECOMBINANT VIRUS VECTOR
Document Type and Number:
WIPO Patent Application WO/2001/029244
Kind Code:
A1
Abstract:
Gene therapy is carried out by efficiently and safely transferring a nucleic acid transporter, which contains a polypeptide comprising diaminobutyric acid and/or its pharmaceutically acceptable salt and a recombinant vector (preferably together with a drug gene), and a drug gene into cells and thus enabling the expression of the drug gene at a high level in the cells.
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Inventors:
GOTO TAKESHI (JP)
IIJIMA OSAMU (JP)
SHIMADA TAKASHI (JP)
IIJIMA OSAMU (JP)
SHIMADA TAKASHI (JP)
Application Number:
PCT/JP2000/007337
Publication Date:
April 26, 2001
Filing Date:
October 20, 2000
Export Citation:
Assignee:
HISAMITSU PHARMACEUTICAL CO (JP)
GOTO TAKESHI (JP)
IIJIMA OSAMU (JP)
SHIMADA TAKASHI (JP)
GOTO TAKESHI (JP)
IIJIMA OSAMU (JP)
SHIMADA TAKASHI (JP)
International Classes:
C12N15/09; A61K35/76; A61K47/42; A61K48/00; C12N15/86; C12N15/867; C12R1/92; (IPC1-7): C12N15/867; C12N15/90
Other References:
C.P. HODGSON ET AL.: "Virosomes: Cationic liposomes enhance retroviral transduction", NATURE BIOTECHNOLOGY, vol. 14, 1996, pages 339 - 342, XP002936577
D.T. CURIEL ET AL.: "Adenovirus enhancement of transferrin-polylysine-mediated gene delivery", PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 8850 - 8854, XP002936578
See also references of EP 1229124A4
D.T. CURIEL ET AL.: "Adenovirus enhancement of transferrin-polylysine-mediated gene delivery", PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 8850 - 8854, XP002936578
See also references of EP 1229124A4
Attorney, Agent or Firm:
Hasegawa, Yoshiki (Okura-honkan 6-12 Ginza 2-chome Chuo-ku, Tokyo, JP)
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