Title:
NUCLEIC ACID VACCINES FOR MUTANT CORONAVIRUS
Document Type and Number:
WIPO Patent Application WO/2023/006062
Kind Code:
A1
Abstract:
Provided herein are therapeutic nucleic acid molecules for managing, preventing and/or treating infectious diseases caused by coronavirus. Also provided herein are therapeutic compositions, including vaccines and lipid nanoparticles, comprising the therapeutic nucleic acids and related therapeutic methods and uses.
Inventors:
YING BO (CN)
LU XISHAN (CN)
YAN HUAYUAN (CN)
LU XISHAN (CN)
YAN HUAYUAN (CN)
Application Number:
PCT/CN2022/108920
Publication Date:
February 02, 2023
Filing Date:
July 29, 2022
Export Citation:
Assignee:
SUZHOU ABOGEN BIOSCIENCES CO LTD (CN)
International Classes:
C12N15/50; A61K9/51; A61K39/215; A61P11/00; A61P31/14; C07K14/165; C07K19/00; C12N15/62; C12N15/88
Foreign References:
| CN112980852A | 2021-06-18 | |||
| CN112480217A | 2021-03-12 | |||
| CN113151312A | 2021-07-23 | |||
| CN111926040A | 2020-11-13 | |||
| CN112300253A | 2021-02-02 | |||
| CN113018449A | 2021-06-25 |
Other References:
RAMANATHAN MUTHUKUMAR; FERGUSON IAN D; MIAO WEILI; KHAVARI PAUL A: "SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity", THE LANCET INFECTIOUS DISEASES, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 8, 19 May 2021 (2021-05-19), AMSTERDAM, NL , pages 1070, XP086711745, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(21)00262-0
SINEGUBOVA MARIA V., ORLOVA NADEZHDA A., KOVNIR SERGEY V., DAYANOVA LUTSIA K., VOROBIEV IVAN I.: "High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1-based plasmid vector", PLOS ONE, vol. 16, no. 2, 2 February 2021 (2021-02-02), pages e0242890, XP093028534, DOI: 10.1371/journal.pone.0242890
SINEGUBOVA MARIA V., ORLOVA NADEZHDA A., KOVNIR SERGEY V., DAYANOVA LUTSIA K., VOROBIEV IVAN I.: "High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1-based plasmid vector", PLOS ONE, vol. 16, no. 2, 2 February 2021 (2021-02-02), pages e0242890, XP093028534, DOI: 10.1371/journal.pone.0242890
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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