Title:
NUCLEIC ACIDS ACTING AS DECOYS FOR THE TREATMENT OF LENTIVIRUS INFECTION
Document Type and Number:
WIPO Patent Application WO/2015/177331
Kind Code:
A3
Abstract:
The present invention relates to nucleic acid sequences which are fragments of HIV-1 genome. The nucleic acids of the present invention are use as decoys for the treatment of lentivirus infection. In particular, the present invention relates to nucleic acids capable of forming at least one G-quadruplex domain and that are capable of inhibiting the replication of at least one lentivirus, such as HIV-1.
Inventors:
AMRANE SAMIR (FR)
MERGNY JEAN-LOUIS (FR)
ANDREOLA MARIE-ALINE (FR)
BEDRAT AMINA (FR)
MERGNY JEAN-LOUIS (FR)
ANDREOLA MARIE-ALINE (FR)
BEDRAT AMINA (FR)
Application Number:
PCT/EP2015/061356
Publication Date:
February 04, 2016
Filing Date:
May 22, 2015
Export Citation:
Assignee:
INSERM INST NAT DE LA SANTÉ ET DE LA RECH MÉDICALE (FR)
CENTRE NAT RECH SCIENT (FR)
UNIV BORDEAUX (FR)
CENTRE NAT RECH SCIENT (FR)
UNIV BORDEAUX (FR)
International Classes:
C12N15/113
Domestic Patent References:
| WO2009143476A2 | 2009-11-26 | |||
| WO1994025037A1 | 1994-11-10 |
Other References:
D. PIEKNA-PRZYBYLSKA ET AL: "Mechanism of HIV-1 RNA Dimerization in the Central Region of the Genome and Significance for Viral Evolution", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 33, 9 July 2013 (2013-07-09), pages 24140 - 24150, XP055154233, ISSN: 0021-9258, DOI: 10.1074/jbc.M113.477265
AURÉLIE FAURE-PERRAUD ET AL: "The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration", ANTIVIRAL THERAPY, 1 January 2011 (2011-01-01), England, pages 383 - 394, XP055154234, Retrieved from the Internet [retrieved on 20141119], DOI: 10.3851/IMP1756
GIOVANNI DI FABIO ET AL: "Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides", CHEMICAL COMMUNICATIONS, vol. 47, no. 8, 1 January 2011 (2011-01-01), pages 2363, XP055154236, ISSN: 1359-7345, DOI: 10.1039/c0cc04751a
CHOU S H ET AL: "DNA aptamers as potential anti-HIV agents", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, HAYWARDS, GB, vol. 30, no. 5, 1 May 2005 (2005-05-01), pages 231 - 234, XP027637328, ISSN: 0968-0004, [retrieved on 20050501]
JING N ET AL: "STABILITY-ACTIVITY RELATIONSHIPS OF A FAMILY OF G-TETRAD FORMING OLIGONUCLEOTIDES AS POTENT HIV INHIBITORS A BASIS FOR ANTI-HIV DRUG DESIGN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 275, no. 5, 4 February 2000 (2000-02-04), pages 3421 - 3430, XP002952224, ISSN: 0021-9258, DOI: 10.1074/JBC.275.5.3421
VALENTINA D'ATRI ET AL: "New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity", CHEMICAL COMMUNICATIONS, vol. 48, no. 76, 1 January 2012 (2012-01-01), pages 9516, XP055154239, ISSN: 1359-7345, DOI: 10.1039/c2cc34399a
V. T. MUKUNDAN ET AL: "HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges", NUCLEIC ACIDS RESEARCH, vol. 39, no. 20, 19 July 2011 (2011-07-19), pages 8984 - 8991, XP055154240, ISSN: 0305-1048, DOI: 10.1093/nar/gkr540
AURÉLIE FAURE-PERRAUD ET AL: "The guanine-quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration", ANTIVIRAL THERAPY, 1 January 2011 (2011-01-01), England, pages 383 - 394, XP055154234, Retrieved from the Internet
GIOVANNI DI FABIO ET AL: "Discovery of novel anti-HIV active G-quadruplex-forming oligonucleotides", CHEMICAL COMMUNICATIONS, vol. 47, no. 8, 1 January 2011 (2011-01-01), pages 2363, XP055154236, ISSN: 1359-7345, DOI: 10.1039/c0cc04751a
CHOU S H ET AL: "DNA aptamers as potential anti-HIV agents", TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER, HAYWARDS, GB, vol. 30, no. 5, 1 May 2005 (2005-05-01), pages 231 - 234, XP027637328, ISSN: 0968-0004, [retrieved on 20050501]
JING N ET AL: "STABILITY-ACTIVITY RELATIONSHIPS OF A FAMILY OF G-TETRAD FORMING OLIGONUCLEOTIDES AS POTENT HIV INHIBITORS A BASIS FOR ANTI-HIV DRUG DESIGN", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 275, no. 5, 4 February 2000 (2000-02-04), pages 3421 - 3430, XP002952224, ISSN: 0021-9258, DOI: 10.1074/JBC.275.5.3421
VALENTINA D'ATRI ET AL: "New anti-HIV aptamers based on tetra-end-linked DNA G-quadruplexes: effect of the base sequence on anti-HIV activity", CHEMICAL COMMUNICATIONS, vol. 48, no. 76, 1 January 2012 (2012-01-01), pages 9516, XP055154239, ISSN: 1359-7345, DOI: 10.1039/c2cc34399a
V. T. MUKUNDAN ET AL: "HIV-1 integrase inhibitor T30177 forms a stacked dimeric G-quadruplex structure containing bulges", NUCLEIC ACIDS RESEARCH, vol. 39, no. 20, 19 July 2011 (2011-07-19), pages 8984 - 8991, XP055154240, ISSN: 0305-1048, DOI: 10.1093/nar/gkr540
Attorney, Agent or Firm:
HIRSCH, Denise (7 rue Watt, Paris, FR)
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