Title:
NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES
Document Type and Number:
WIPO Patent Application WO2001055327
Kind Code:
A3
Abstract:
The present invention relates to novel pancreatic related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic antigens", and the use of such pancreatic antigens for detecting disorders of the pancreas, particularly the presence of pancreatic cancer and pancreatic cancer metastases. More specifically, isolated pancreatic associated nucleic acid molecules are provided encoding novel pancreatic associated polypeptides. Novel pancreatic polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human pancreatic associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
Inventors:
ROSEN CRAIG A (US)
BARASH STEVEN C (US)
RUBEN STEVEN M (US)
BARASH STEVEN C (US)
RUBEN STEVEN M (US)
Application Number:
PCT/US2001/001352
Publication Date:
February 28, 2002
Filing Date:
January 17, 2001
Export Citation:
Assignee:
HUMAN GENOME SCIENCES INC (US)
ROSEN CRAIG A (US)
BARASH STEVEN C (US)
RUBEN STEVEN M (US)
ROSEN CRAIG A (US)
BARASH STEVEN C (US)
RUBEN STEVEN M (US)
International Classes:
C07K14/47; C07K14/705; C07K16/18; C12N1/13; C12N1/15; C12N1/21; C12N9/00; C12N9/64; C12N15/12; C12N15/60; C12Q1/68; A61K38/00; A61K48/00; (IPC1-7): C07H21/02; C07H21/04; C07K5/00; C07K14/00; C12N1/20; C12N5/00; C12N15/63; C12P21/06; C12Q1/68
Domestic Patent References:
| WO1999067386A2 | 1999-12-29 |
Foreign References:
| US5840870A | 1998-11-24 | |||
| US5998165A | 1999-12-07 | |||
| US4446240A | 1984-05-01 |
Other References:
DATABASE GENBANK [online] 19 January 2000 (2000-01-19), ROSENTHAL ET AL.: "Human normal pancreas tissue derived cDNA 35", XP002941890, Database accession no. Z41420
DATABASE GENBANK [online] 19 January 2000 (2000-01-19), ROSENTHAL ET AL.: "Human normal pancreas tissue derived protein 18", XP002941891, Database accession no. Y59910
DATABASE GENBANK [online] 19 January 2000 (2000-01-19), ROSENTHAL ET AL.: "Human normal pancreas tissue derived protein 18", XP002941891, Database accession no. Y59910
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