Title:
NUCLEOCYTOPLASMIC REGULATOR OF AUTOPHAGY-ASSOCIATED TRANSCRIPTION FACTORS
Document Type and Number:
WIPO Patent Application WO/2018/191707
Kind Code:
A3
Abstract:
Provided herein, are compositions and methods of treatment for neurodegenerative diseases, such as neurodegenerative diseases associated with aging and methods for increasing longevity by inhibiting the expression of the protein exportin-1 (XPOl, CRM-1 or karyopherin) or a fragment thereof.
Inventors:
LAPIERRE LOUIS (US)
Application Number:
PCT/US2018/027640
Publication Date:
December 13, 2018
Filing Date:
April 13, 2018
Export Citation:
Assignee:
UNIV BROWN (US)
International Classes:
C07D249/08; C07D257/04; C07D401/12; C07D403/06; C07D403/12
Domestic Patent References:
| WO2018191707A2 | 2018-10-18 |
Foreign References:
| US20160304472A1 | 2016-10-20 | |||
| US20120148565A1 | 2012-06-14 |
Other References:
GRAVINA ET AL.: "KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models", BMC CANCER, vol. 15, no. 941, 1 December 2015 (2015-12-01), pages 941, XP055551900, Retrieved from the Internet
HOWELL ET AL.: "Nuclear Export-independent Inhibition of Foxa2 by Insulin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 37, 11 September 2009 (2009-09-11), pages 24816 - 24824, XP055551903, Retrieved from the Internet
HOWELL ET AL.: "Nuclear Export-independent Inhibition of Foxa2 by Insulin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 37, 11 September 2009 (2009-09-11), pages 24816 - 24824, XP055551903, Retrieved from the Internet
Attorney, Agent or Firm:
BEATTIE, Ingrid, A. et al. (US)
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