Title:
NUCLEOPHILIC SUBSTITUTION REACTIONS OF DIFLUOROMETHYL PHENYL SULFONE WITH ALKYL HALIDES LEADING TO THE FACILE SYNTHESIS OF TERMINAL 1,1-DIFLUORO-1-ALKENES AND DIFLUOROMETHYLALKANES
Document Type and Number:
WIPO Patent Application WO2005097739
Kind Code:
A3
Abstract:
(Benzenesulfonyl)difluoromethyl anion, in situ generated from difluoromethyl phenyl sulfone and a base, was found to easily undergo nucleophilic substitution reactions (SN2 with primary alkyl halides, elemental halogens, and perfluoroalkyl halides with good selectivity. The formed (Benzenesulfonyl) difluoromethylalkanes are useful intermediates for the facile preparation of 1,1-difluoro-1alkenes and difluoromethylalkanes. Thus, difluoromethyl phenyl sulfone acts as both "CF2=" and CF2H" synthons.
More Like This:
| WO/2009/006773 | AN OPTICALLY ACTIVE N- (α-MERCAPTOPROPIONY) GLYCINE |
| WO/2016/024012 | METHOD FOR PRODUCING 2-MERCAPTOETHANOL |
Inventors:
PRAKASH G K SURYA (US)
HU JINBO (US)
OLAH GEORGE A (US)
WANG YING (US)
HU JINBO (US)
OLAH GEORGE A (US)
WANG YING (US)
Application Number:
PCT/US2005/010225
Publication Date:
May 18, 2006
Filing Date:
March 25, 2005
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
PRAKASH G K SURYA (US)
HU JINBO (US)
OLAH GEORGE A (US)
WANG YING (US)
PRAKASH G K SURYA (US)
HU JINBO (US)
OLAH GEORGE A (US)
WANG YING (US)
International Classes:
C07C319/02; C07C17/361; C07C41/18; C07C43/225; C07C45/90; C07C315/04; C07C319/08; C07C317/14; C07C317/18
Foreign References:
| US20040230079A1 | 2004-11-18 |
Other References:
STAHLY G.P.: "Nucleophilic Addition of Difluoromethyl Phenyl Sulfone to Aldehydes and Various Transformations of the Resulting Alcohols", JOURNAL OF FLUORINE CHEMISTRY, vol. 43, 1989, pages 53 - 66, XP002997495
Download PDF: