Title:
NUCLEOSIDE 5'-MONOPHOSPHATE MIMICS AND THEIR PRODRUGS
Document Type and Number:
WIPO Patent Application WO2003073989
Kind Code:
A3
Abstract:
The present invention relates to novel nucleoside 5'-monophosphate mimics, which contain novel nucleoside bases and phosphate moiety mimics optionally having sugar-modifications. The nucleotide mimics of the present invention, in a form of a pharmaceutically acceptable salt, a pharmaceutically acceptable prodrug, or a pharmaceutical formulation, are useful as antiviral, antimicrobial, anticancer, and immunomodulatory agents. The present invention provides a method for the treatment of viral infections, microbial infections, and proliferative disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of the present invention optionally in combination with other pharmaceutically active agents.
More Like This:
| JPH07196658 | COMPOUND CONTAINING CONDENSED POLYCYCLIC LACTAM |
| JP2009544742 | ALDH-2 inhibitor in the treatment of addiction |
| WO/1992/014740 | QUINOXALINE PHOSPHONO-AMINO ACIDS |
Inventors:
COOK PHILLIP DAN
WANG GUANGYI
BRUICE THOMAS W
RAJAPPAN VASANTHANKUMAR
SAKTHIVEL KANDASAMY
TUCKER KATHLEEN D
BROOKS JENNIFER L
LEEDS JANET M
ARIZA MARIA EUGENIA
FAGAN PATRICK C
WANG GUANGYI
BRUICE THOMAS W
RAJAPPAN VASANTHANKUMAR
SAKTHIVEL KANDASAMY
TUCKER KATHLEEN D
BROOKS JENNIFER L
LEEDS JANET M
ARIZA MARIA EUGENIA
FAGAN PATRICK C
Application Number:
PCT/US2003/006171
Publication Date:
September 16, 2004
Filing Date:
February 28, 2003
Export Citation:
Assignee:
BIOTA INC (US)
International Classes:
A61K31/675; A61K31/7056; A61K45/06; A61P31/04; A61P31/12; A61P35/00; A61P37/02; C07H19/04; C07H19/044; C07H19/052; C07H19/056; C07H19/10; (IPC1-7): C07H19/056; A61K31/70
Domestic Patent References:
| WO1992002213A1 | 1992-02-20 |
Foreign References:
| US6312662B1 | 2001-11-06 |
Other References:
DATABASE CAPLUS [online] JOSEPHSON ET AL: "Macromolecular prodrugs of nucleotide analogs", XP002978996, Database accession no. 1997:511689
DATABASE CAPLUS [online] GUILLEMIN ET AL: "Neuron stimulation by ribavirin, and analogs thereof", XP002978997, Database accession no. 2000:368114
DATABASE CAPLUS [online] GUILLEMIN ET AL: "Neuron stimulation by ribavirin, and analogs thereof", XP002978997, Database accession no. 2000:368114
Download PDF: