Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NUCLEOSIDE ANALOGUE DERIVATIVE AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/069645
Kind Code:
A1
Abstract:
Provided is an analysis technique for detecting 8-oxo-dG in DNA using a compound represented by formula (II). In formula (II): R3 is H, a protecting group of the 3'-hydroxyl group, oligodeoxynucleotide group 1 (ODN group 1) or -P(OR5)R6 [wherein R5 is a protecting group of the phosphate group, and R6 is a dialkylamino group carrying two alkyl groups that have 1 to 6 carbons, said alkyl groups being optionally the same or different, attached to a nitrogen atom]; and R4 is H, a protecting group of the 5'-hydroxyl group or oligodeoxynucleotide group 2 (ODN group 2). The compound according to the present invention is useful in detecting an oxidative mutation in a nucleic acid.

Inventors:
SASAKI Shigeki (NATIONAL UNIVERSITY CORPORATION 6-10-1, Hakozaki, Higashi-ku, Fukuoka-sh, Fukuoka 81, 〒8128581, JP)
TANIGUCHI Yosuke (NATIONAL UNIVERSITY CORPORATION 6-10-1, Hakozaki, Higashi-ku, Fukuoka-sh, Fukuoka 81, 〒8128581, JP)
FUKABORI Keitaro (NATIONAL UNIVERSITY CORPORATION 6-10-1, Hakozaki, Higashi-ku, Fukuoka-sh, Fukuoka 81, 〒8128581, JP)
Application Number:
JP2013/079789
Publication Date:
May 08, 2014
Filing Date:
November 01, 2013
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (6-10-1, Hakozaki Higashi-ku, Fukuoka-sh, Fukuoka 81, 〒8128581, JP)
International Classes:
C07H19/173; C07H21/04
Domestic Patent References:
WO2012077800A1
Other References:
TANIGUCHI Y ET AL. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 133, 27 April 2011, pages 7272 - 7275
TANIGUCHI Y ET AL. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 22, 04 November 2011, pages 543 - 546
Attorney, Agent or Firm:
HAMADA Yuriko et al. (Eikoh Patent Firm, Toranomon East Bldg. 10F 7-13, Nishi-Shimbashi 1-chome, Minato-k, Tokyo 03, 〒1050003, JP)
Download PDF: