Title:
NUCLEOSIDE ANALOGUE REGULATING MAMMALIAN CIRCADIAN RHYTHM
Document Type and Number:
WIPO Patent Application WO/2018/133835
Kind Code:
A1
Abstract:
A circadian rhythm phase-shifting nucleoside analogue is used to modulate circadian rhythm.
Inventors:
ZHANG ERQUAN (CN)
QI XIANGBING (CN)
JU DAPENG (CN)
ZHOU GUANSHEN (CN)
ZHAO HAIJIAO (CN)
MEI LONG (CN)
WANG ZHIQIANG (CN)
LIANG LEIMING (CN)
QI XIANGBING (CN)
JU DAPENG (CN)
ZHOU GUANSHEN (CN)
ZHAO HAIJIAO (CN)
MEI LONG (CN)
WANG ZHIQIANG (CN)
LIANG LEIMING (CN)
Application Number:
PCT/CN2018/073378
Publication Date:
July 26, 2018
Filing Date:
January 19, 2018
Export Citation:
Assignee:
NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN)
International Classes:
A61K31/7076; A61K31/519; A61K31/52; A61K31/7056; A61K31/706; A61K31/7064; A61K31/708; A61P25/00
Domestic Patent References:
| WO2008066626A2 | 2008-06-05 | |||
| WO2006023590A1 | 2006-03-02 | |||
| WO2015024819A1 | 2015-02-26 |
Foreign References:
| FR6164M | 1968-07-08 | |||
| SU1119336A1 | 1986-12-30 | |||
| CN101259129A | 2008-09-10 | |||
| US20040127508A1 | 2004-07-01 | |||
| US4386093A | 1983-05-31 |
Other References:
JONES TL ET AL.: "Circdian Regulation of Sucrose Phosphate Synthase Activity in Tomato by Protein Phosphatase Activity", PLANT PHYSIOL., vol. 113, no. 4, 30 April 1997 (1997-04-30), pages 1167 - 1175, XP055506515, ISSN: 0032-0889
JOHN S. O'NEILLL ET AL.: "Circadian rhythms persist without transcription in a eukaryote", NATURE, vol. 469, no. 7331, 27 January 2011 (2011-01-27), pages 554 - 558, XP055506549, ISSN: 0028-0836
G. GOSSELIN ET AL.: "Synthesis and biological evaluation of new 5, 6-dichlorobenzimidazole nucleoside derivatives", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 5, no. 4, 31 December 1994 (1994-12-31), pages 243 - 256, XP002078623, ISSN: 0956-3202
RAPP M ET AL.: "Antitrypanosomal Activity of 5'-Deoxy-5'-(iodomethylene)adenosine and Related 6-N-Cyclopropyladenosine Analogues", J. MED. CHEM., vol. 49, no. 6, 23 March 2006 (2006-03-23), pages 2096 - 2102, XP055506559, ISSN: 0022-2623
SZUCOVA L ET AL.: "Synthesis, characterization and biological activity of ring-substituted 6- benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives", IOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 5, 1 March 2009 (2009-03-01), pages 1938 - 1947, XP025992066, ISSN: 0968-0896
BOOKSER BC ET AL.: "High-Throughput Five Minute Microwave Accelerated Glycosylation Approach to the Synthesis of Nucleoside Libraries", J.ORG. CHEM., vol. 72, no. 1, 1 March 2009 (2009-03-01), pages 173 - 179, XP055054315, ISSN: 0022-3263
TAI-SHUN LIN ET AL.: "8-Substituted Guanosine and 2'-Deoxyguanosine Derivatives as Potential Inducers of the Differentiation of Friend Erythroleukemia Cells", J. MED. CHEM., vol. 28, no. 9, 30 September 1985 (1985-09-30), pages 1194 - 1198, XP055506574, ISSN: 0022-2623
SHIKHA MAHAJAN ET AL.: "Synthesis and Evaluation of a Novel Adenosine-Ribose Probe for Global-Scale Profiling of Nucleoside and Nucleotide-Binding Proteins", PLOS ONE, vol. 10, no. 2, 28 February 2015 (2015-02-28), pages e0115644, XP055506577, ISSN: 1932-6203
JOHN S. O'NEILLL ET AL.: "Circadian rhythms persist without transcription in a eukaryote", NATURE, vol. 469, no. 7331, 27 January 2011 (2011-01-27), pages 554 - 558, XP055506549, ISSN: 0028-0836
G. GOSSELIN ET AL.: "Synthesis and biological evaluation of new 5, 6-dichlorobenzimidazole nucleoside derivatives", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 5, no. 4, 31 December 1994 (1994-12-31), pages 243 - 256, XP002078623, ISSN: 0956-3202
RAPP M ET AL.: "Antitrypanosomal Activity of 5'-Deoxy-5'-(iodomethylene)adenosine and Related 6-N-Cyclopropyladenosine Analogues", J. MED. CHEM., vol. 49, no. 6, 23 March 2006 (2006-03-23), pages 2096 - 2102, XP055506559, ISSN: 0022-2623
SZUCOVA L ET AL.: "Synthesis, characterization and biological activity of ring-substituted 6- benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives", IOORGANIC & MEDICINAL CHEMISTRY, vol. 17, no. 5, 1 March 2009 (2009-03-01), pages 1938 - 1947, XP025992066, ISSN: 0968-0896
BOOKSER BC ET AL.: "High-Throughput Five Minute Microwave Accelerated Glycosylation Approach to the Synthesis of Nucleoside Libraries", J.ORG. CHEM., vol. 72, no. 1, 1 March 2009 (2009-03-01), pages 173 - 179, XP055054315, ISSN: 0022-3263
TAI-SHUN LIN ET AL.: "8-Substituted Guanosine and 2'-Deoxyguanosine Derivatives as Potential Inducers of the Differentiation of Friend Erythroleukemia Cells", J. MED. CHEM., vol. 28, no. 9, 30 September 1985 (1985-09-30), pages 1194 - 1198, XP055506574, ISSN: 0022-2623
SHIKHA MAHAJAN ET AL.: "Synthesis and Evaluation of a Novel Adenosine-Ribose Probe for Global-Scale Profiling of Nucleoside and Nucleotide-Binding Proteins", PLOS ONE, vol. 10, no. 2, 28 February 2015 (2015-02-28), pages e0115644, XP055506577, ISSN: 1932-6203
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