Title:
NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION
Document Type and Number:
WIPO Patent Application WO2006012078
Kind Code:
A3
Abstract:
The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
Inventors:
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
OLSEN DAVID B (US)
Application Number:
PCT/US2005/021684
Publication Date:
June 01, 2006
Filing Date:
June 20, 2005
Export Citation:
Assignee:
MERCK & CO INC (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
International Classes:
C07H19/00; A61K31/70
Foreign References:
| US6638919B2 | 2003-10-28 | |||
| US6475985B1 | 2002-11-05 | |||
| US6660721B2 | 2003-12-09 |
Other References:
See also references of EP 1773355A4
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