NUCLEOSIDE COMPOUND AND APPLICATION THEREOF IN THE TREATMENT OF FELINE INFECTIOUS PERITONITIS

Title:

NUCLEOSIDE COMPOUND AND APPLICATION THEREOF IN THE TREATMENT OF FELINE INFECTIOUS PERITONITIS

Document Type and Number:

WIPO Patent Application WO/2022/222994

Kind Code:

A1

Abstract:

The present invention relates to a nucleoside compound and an application thereof in the treatment of feline infectious peritonitis. The compound is a GS-441524 analog. The compound has a small toxic effect on normal cells of cats, and has an obvious inhibitory effect on feline coronavirus. The compound can be used for preparing a feline coronavirus inhibitor and for treating feline infectious peritonitis, has the advantages of a good curative effect and high safety, and is extremely good in water solubility and easier to absorb.

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Inventors:

LEI YANG (CN)
CAO GANG (CN)
HU RONG (CN)

Application Number:

PCT/CN2022/088179

Publication Date:

October 27, 2022

Filing Date:

April 21, 2022

Export Citation:

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Assignee:

VIGONVITA LIFE SCIENCES CO LTD (CN)

International Classes:

C07D487/04; A61K31/53; A61K31/5377; A61P29/00; A61P31/14

Foreign References:

CN111135184A	2020-05-12
CN111961057A	2020-11-20
CN113735862A	2021-12-03
CN112778310A	2021-05-11
CN113185519A	2021-07-30

Other References:

"Molecular Pharmaceutics", 31 January 2010, HUNAN NORMAL UNIVERSITY PRESS, CN, ISBN: 7-5648-0114-X, article CHEN, YUXIANG: "Passage; Molecular Pharmaceutics", pages: 197, XP009540903
"Handbook of Chemicals", 1994, article "Periodic Table of Chemical Elements"
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
MICHAEL B. SMITHJERRY MARCH: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
S. M. BERGE ET AL., J PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
"Chinese Pharmacopoeia", 2020, article "Part Four, General Rule 0512"

Attorney, Agent or Firm:

SUZHOU JINSHANG INTELLECTUAL PROPERTY LAW FIRM (GENERAL PARTNERSHIP) (CN)

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