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Title:
NUCLEOSIDE DERIVATIVE OR SALT THEREOF, REAGENT FOR SYNTHESIZING POLYNUCLEOTIDE, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE
Document Type and Number:
WIPO Patent Application WO/2018/051581
Kind Code:
A1
Abstract:
Provided are a novel nucleoside derivative or a salt thereof, a reagent for synthesizing a polynucleotide, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. This nucleoside derivative or a salt thereof is characterized by being represented by chemical formula (1). In chemical formula (1), Su represents an atomic group having a sugar backbone in the nucleoside residue or an atomic group having a sugar phosphate backbone in the nucleotide residue, which may or may not have a protecting group, L1 and L2 each independently represent a linear or branched saturated or unsaturated hydrocarbon group having 2-10 carbon atoms, X1 and X2 each independently represent an imino group (-NR1-), an ether group (-O-), or a thioether group (-S-), and R1 represents a hydrogen atom or a linear or branched saturated or unsaturated hydrocarbon group having 2-10 carbon atoms.

Inventors:
MINAGAWA HIROTAKA (JP)
HORII KATSUNORI (JP)
AKITOMI JOU (JP)
KANEKO NAOTO (JP)
WAGA IWAO (JP)
KUWAHARA MASAYASU (JP)
Application Number:
JP2017/020065
Publication Date:
March 22, 2018
Filing Date:
May 30, 2017
Export Citation:
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Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
UNIV GUNMA NAT UNIV CORP (JP)
International Classes:
C07H19/20; C07K16/00; C12N9/26; C12N15/115
Domestic Patent References:
WO2015064223A12015-05-07
Foreign References:
JP2016056136A2016-04-21
JP2013040118A2013-02-28
Other References:
IMAIZUMI,Y. ET AL.: "Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 25, 2013, pages 9412 - 9419, XP055422191, DOI: doi:10.1021/ja4012222
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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