Title:
NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
Document Type and Number:
WIPO Patent Application WO2002057425
Kind Code:
A3
Abstract:
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
Inventors:
CARROLL STEVEN S (US)
LAFEMINA ROBERT L (US)
HALL DAWN L (US)
HIMMELBERGER AMY L (US)
KUO LAWRENCE C (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
RUTKOWSKI CARRIE A (US)
TOMASSINI JOANNE E (US)
AN HAOYUN (US)
BHAT BALKRISHEN (US)
BHAT NEELIMA (US)
COOK PHILLIP DAN (US)
ELDRUP ANNE B (US)
GUINOSSO CHARLES J (US)
PRHAVC MARIJA (US)
PRAKASH THAZHA P (US)
LAFEMINA ROBERT L (US)
HALL DAWN L (US)
HIMMELBERGER AMY L (US)
KUO LAWRENCE C (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
RUTKOWSKI CARRIE A (US)
TOMASSINI JOANNE E (US)
AN HAOYUN (US)
BHAT BALKRISHEN (US)
BHAT NEELIMA (US)
COOK PHILLIP DAN (US)
ELDRUP ANNE B (US)
GUINOSSO CHARLES J (US)
PRHAVC MARIJA (US)
PRAKASH THAZHA P (US)
Application Number:
PCT/US2002/001531
Publication Date:
April 21, 2005
Filing Date:
January 18, 2002
Export Citation:
Assignee:
MERCK & CO INC (US)
ISIS PHARMACEUTICALS INC (US)
CARROLL STEVEN S (US)
LAFEMINA ROBERT L (US)
HALL DAWN L (US)
HIMMELBERGER AMY L (US)
KUO LAWRENCE C (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
RUTKOWSKI CARRIE A (US)
TOMASSINI JOANNE E (US)
AN HAOYUN (US)
BHAT BALKRISHEN (US)
BHAT NEELIMA (US)
COOK PHILLIP DAN (US)
ELDRUP ANNE B (US)
GUINOSSO CHARLES J (US)
PRHAVC MARIJA (US)
PRAKASH THAZHA P (US)
ISIS PHARMACEUTICALS INC (US)
CARROLL STEVEN S (US)
LAFEMINA ROBERT L (US)
HALL DAWN L (US)
HIMMELBERGER AMY L (US)
KUO LAWRENCE C (US)
MACCOSS MALCOLM (US)
OLSEN DAVID B (US)
RUTKOWSKI CARRIE A (US)
TOMASSINI JOANNE E (US)
AN HAOYUN (US)
BHAT BALKRISHEN (US)
BHAT NEELIMA (US)
COOK PHILLIP DAN (US)
ELDRUP ANNE B (US)
GUINOSSO CHARLES J (US)
PRHAVC MARIJA (US)
PRAKASH THAZHA P (US)
International Classes:
A61K31/519; A61K31/70; A61K31/7052; C07D487/04; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7076; A61K31/708; A61K31/7105; A61K31/712; A61K38/21; A61K45/00; A61K45/06; A61P1/16; A61P31/14; A61P43/00; C07D473/00; C07D487/02; C07H19/00; C07H19/04; C07H19/048; C07H19/06; C07H19/067; C07H19/09; C07H19/10; C07H19/14; C07H19/16; C07H19/167; C07H19/173; C07H19/19; C07H19/20; C07H; C12N; (IPC1-7): A61K31/70; A61K31/712; A61K31/7105
Foreign References:
| US6110901A | 2000-08-29 | |||
| US6063628A | 2000-05-16 |
Other References:
DATABASE CAPLUS [online] ILYIN, ET AL.: "Ribavirin Inhibits Protein Synthesis and Cell Proliferation Induced by Mitogenic Factors in Primary Human and Rat Hepatocytes", XP002984854, accession no. STN Database accession no. 1998:384809
DATABASE CAPLUS [online] HARADA, ET AL.: "The Nucleotide Sequence of Nuclear 4.8S RNA of Mouse Cells", XP002984855, accession no. STN Database accession no. 1980:599421
DATABASE CAPLUS [online] HARADA, ET AL.: "The Nucleotide Sequence of Nuclear 4.8S RNA of Mouse Cells", XP002984855, accession no. STN Database accession no. 1980:599421
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