Title:
NUCLEOSIDE AND NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON CENTERS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO/2008/087558
Kind Code:
A3
Abstract:
The present invention comprises compounds useful as antiviral or antitumor agents. The compounds comprise nucleotide analogues that comprise tetrahydrofuranyl or tetrahydrothienyl moeities with quaternary centers at the 3' position. The nucleotide analogues can be used to inhibit cancer or viruses. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting diseases or conditions associated with cancers and viruses. Thus, the present invention also comprising pharmaceutical formulations comprising the compounds and methods of using the compounds and formulations to inhibit viruses or tumors and treat, prevent, or inhibit the foregoing diseases.
Inventors:
GUINDON YVAN (CA)
Application Number:
PCT/IB2008/000697
Publication Date:
April 21, 2011
Filing Date:
January 17, 2008
Export Citation:
Assignee:
INST RECH S CLINIQUES DE MONTREAL (CA)
GUINDON YVAN (CA)
GUINDON YVAN (CA)
International Classes:
C07D407/04; A61K31/506; A61K31/52; A61P31/12; A61P35/00; C07D409/04; C07D473/18; C07D473/34; C07D493/04; C07H19/04; C07H19/06; C07H19/073; C07H19/16; C07H19/173
Domestic Patent References:
| WO2002032920A2 | 2002-04-25 |
Other References:
ZHONG ET AL.: "Photochemistry on Soluble Polymer Supports: Synthesis of Nucleosides", ORGANIC LETTERS, vol. 4, no. 25, 2002, pages 4415 - 4417, XP002983659
Attorney, Agent or Firm:
LECLERC, Alain, M. et al. (2000 McGill CollegeSuite 220, Montréal Québec H3A 3H3, CA)
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