Title:
NUCLEOSIDE AND NUCLEOTIDE, HAVING NITROGEN-CONTAINING HETERCYCLE STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2014/126229
Kind Code:
A1
Abstract:
The present invention provides a novel nucleoside or nucleotide usable as a material for the synthesis of a nucleic acid medicine, particularly, a compound represented by formula (I) or a salt thereof [wherein: Y1 is CR6 or N; Y2 is CR7 or N; Y3 is CR8 or N; R6, R7 and R8 are each independently a hydrogen atom, halogen, cyano, a substituted or unsubstituted alkyl, or the like; Bx is a nucleic acid base moiety; Z1 and Z2 are each independently a hydrogen atom, a hydroxyl-protecting group or a reactive phosphorus group; R1 to R5 are each independently a hydrogen atom, halogen, cyano, a substituted or unsubstituted alkyl, or the like; and n is an integer of 0 to 3].
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Inventors:
MITSUOKA YASUNORI (JP)
KUGIMIYA AKIRA (JP)
YAHARA AIKO (JP)
KUGIMIYA AKIRA (JP)
YAHARA AIKO (JP)
Application Number:
PCT/JP2014/053580
Publication Date:
August 21, 2014
Filing Date:
February 17, 2014
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07H19/06; C07H21/00
Domestic Patent References:
| WO2014046212A1 | 2014-03-27 | |||
| WO2011052436A1 | 2011-05-05 | |||
| WO2005021570A1 | 2005-03-10 | |||
| WO2010021344A1 | 2010-02-25 | |||
| WO2011156202A1 | 2011-12-15 | |||
| WO1998039352A1 | 1998-09-11 | |||
| WO2005021570A1 | 2005-03-10 | |||
| WO2003068795A1 | 2003-08-21 | |||
| WO2011052436A1 | 2011-05-05 | |||
| WO2011156202A1 | 2011-12-15 |
Foreign References:
| JP2002516256A | 2002-06-04 |
Other References:
PROC. NATL. ACAD. SCI. USA, vol. 97, no. 10, 2000, pages 5633 - 5638
BIOORG. MED. CHEM., vol. 14, 2006, pages 1029 - 1038
CHEM. COMMUN., 2007, pages 3765 - 3767
J. AM. CHEM. SOC., vol. 130, no. 14, 2008, pages 4886 - 4896
NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
BIOORG. MED. CHEM., vol. 9, 2001, pages 1001 - 1011
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987
"Design of Prodrugs", 1985, ELSEVIER
TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859 - 1862
J. MED. CHEM., vol. 43, 2000, pages 4516
CHEMMEDCHEM, vol. 6, 2011, pages 840
J.MED.CHEM., vol. 43, 2000, pages 4516
See also references of EP 2957567A4
BIOORG. MED. CHEM., vol. 14, 2006, pages 1029 - 1038
CHEM. COMMUN., 2007, pages 3765 - 3767
J. AM. CHEM. SOC., vol. 130, no. 14, 2008, pages 4886 - 4896
NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
BIOORG. MED. CHEM., vol. 9, 2001, pages 1001 - 1011
"Isotopes in the Physical and Biomedical Sciences", vol. 1, 1987
"Design of Prodrugs", 1985, ELSEVIER
TETRAHEDRON LETTERS, vol. 22, 1981, pages 1859 - 1862
J. MED. CHEM., vol. 43, 2000, pages 4516
CHEMMEDCHEM, vol. 6, 2011, pages 840
J.MED.CHEM., vol. 43, 2000, pages 4516
See also references of EP 2957567A4
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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