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Patent Searching and Data


Title:
NUCLEOSIDE PHOSPHORAMIDATE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/074596
Kind Code:
A1
Abstract:
The present invention provides a nucleoside phosphoramidate derivative and an application thereof, which is specifically a compound represented by formula I, or a pharmaceutically acceptable acidic salt, a solvate or a hydrate thereof. R1 is C1-4 alkyl; R2 is any substituted phenyl or naphthyl, and a substituent group thereof is selected from C1-4 alkyl and C1-4 alkoxy; and R3 is amino acid acyl or peptide acyl. The compound in the present invention can be used to prepare a drug for preventing or treating mammalian infectious diseases, and especially used to prepare drugs for preventing or treating hepatitis c, liver cirrhosis, and a liver cancer.

Inventors:
NI SHUAIJIAN (CN)
Application Number:
PCT/CN2015/094101
Publication Date:
May 19, 2016
Filing Date:
November 09, 2015
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Assignee:
NANJING MAJOR BIOLOG TECHNOLOGY CO LTD (CN)
International Classes:
C07H19/10; A61K31/7072; C07H1/00
Domestic Patent References:
WO2010135569A12010-11-25
WO2011039221A22011-04-07
WO2014209983A12014-12-31
Foreign References:
CN1891710A2007-01-10
US20070167353A12007-07-19
Attorney, Agent or Firm:
NANJING TIANHUA PATENT AGENT CO., LTD. (CN)
南京天华专利代理有限责任公司 (CN)
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