Title:
NUCLEOSIDE PHOSPHORAMIDATES
Document Type and Number:
WIPO Patent Application WO/2011/123645
Kind Code:
A3
Abstract:
Disclosed herein are nucleoside phosphorainidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
Inventors:
ROSS BRUCE S (US)
SOFIA MICHAEL JOSEPH (US)
PAMULAPATI GANAPATI REDDY (US)
RACHAKONDA SUGUNA (US)
ZHANG HAI-REN (US)
CHUN BYOUNG-KWON (US)
WANG PEIYUAN (US)
SOFIA MICHAEL JOSEPH (US)
PAMULAPATI GANAPATI REDDY (US)
RACHAKONDA SUGUNA (US)
ZHANG HAI-REN (US)
CHUN BYOUNG-KWON (US)
WANG PEIYUAN (US)
Application Number:
PCT/US2011/030725
Publication Date:
December 29, 2011
Filing Date:
March 31, 2011
Export Citation:
Assignee:
PHARMASSET INC (US)
ROSS BRUCE S (US)
SOFIA MICHAEL JOSEPH (US)
PAMULAPATI GANAPATI REDDY (US)
RACHAKONDA SUGUNA (US)
ZHANG HAI-REN (US)
CHUN BYOUNG-KWON (US)
WANG PEIYUAN (US)
ROSS BRUCE S (US)
SOFIA MICHAEL JOSEPH (US)
PAMULAPATI GANAPATI REDDY (US)
RACHAKONDA SUGUNA (US)
ZHANG HAI-REN (US)
CHUN BYOUNG-KWON (US)
WANG PEIYUAN (US)
International Classes:
C07H19/06; A61K31/664; A61K31/7056; A61K31/7072; A61P31/14; C07F9/24; C07F9/655; C07F9/6558; C07F9/6561; C07H19/04; C07H19/044; C07H19/052; C07H19/10; C07H19/207; C07H19/24
Domestic Patent References:
| WO2008121634A2 | 2008-10-09 | |||
| WO2010135569A1 | 2010-11-25 |
Foreign References:
| US20070042988A1 | 2007-02-22 |
Other References:
MICHAEL J. SOFIA ET AL: "Discovery of a beta-D-2'-Deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 19, 16 September 2010 (2010-09-16), pages 7202 - 7218, XP055004442, ISSN: 0022-2623, DOI: 10.1021/jm100863x
Attorney, Agent or Firm:
KOWALCHYK, Katherine, M. et al. (P.O.Box 2903Minneapolis, MN, US)
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