Title:
NUCLEOSIDE-TYPE ANTIBIOTIC DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/101061
Kind Code:
A1
Abstract:
Disclosed are a compound having an antibacterial activity, more preferably an antibacterial nucleoside compound that can inhibit the activity of MraY to exert an antibacterial activity, particularly a novel derivative of Muraymycin that is an MraY inhibitor. Specifically disclosed is a novel derivative of Muraymycin or a pharmaceutically acceptable salt thereof. The compound can be supplied synthetic chemically and readily while maintaining the activity thereof at a level equivalent to or higher compared with those of conventional nucleic acid-type antibiotics.
Inventors:
MATSUDA AKIRA
ICHIKAWA SATOSHI
ICHIKAWA SATOSHI
Application Number:
PCT/JP2010/052903
Publication Date:
September 10, 2010
Filing Date:
February 24, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
MATSUDA AKIRA
ICHIKAWA SATOSHI
UNIV HOKKAIDO NAT UNIV CORP (JP)
MATSUDA AKIRA
ICHIKAWA SATOSHI
International Classes:
C07H19/067; A61K31/7072; A61P31/04; A61P43/00
Domestic Patent References:
| WO2001012643A1 | 2001-02-22 | |||
| WO2004046368A1 | 2004-06-03 |
Foreign References:
| JP2008074710A | 2008-04-03 |
Other References:
LIN YANG-I ET AL.: "Muraymycins, novel peptidoglycan biosynthesis inhibitors: semisynthesis and SAR of Their derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 17, 2002, pages 2341 - 2344
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
Shusaku Yamamoto (JP)
Shusaku Yamamoto (JP)
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