Title:
NUCLEOTIDE LIPID ESTER DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004083155
Kind Code:
A3
Abstract:
The subject of the present invention are specific lipidesters of halogenated-adenine nucleotides and the use of such lipidesters in the treatment of tumors.
Inventors:
HERRMANN DIETER (DE)
HECKL-OESTREICHER BRIGITTE (DE)
MUELLER CHRISTOPH (DE)
LUTZ CHRISTIAN (DE)
VOIGT ROBERT (DE)
BAUTA WILLIAM E (US)
HECKL-OESTREICHER BRIGITTE (DE)
MUELLER CHRISTOPH (DE)
LUTZ CHRISTIAN (DE)
VOIGT ROBERT (DE)
BAUTA WILLIAM E (US)
Application Number:
PCT/EP2004/002810
Publication Date:
March 31, 2005
Filing Date:
March 18, 2004
Export Citation:
Assignee:
HERRMANN DIETER (DE)
HECKL-OESTREICHER BRIGITTE (DE)
MUELLER CHRISTOPH (DE)
LUTZ CHRISTIAN (DE)
VOIGT ROBERT (DE)
BAUTA WILLIAM E (US)
HECKL-OESTREICHER BRIGITTE (DE)
MUELLER CHRISTOPH (DE)
LUTZ CHRISTIAN (DE)
VOIGT ROBERT (DE)
BAUTA WILLIAM E (US)
International Classes:
A61K31/7076; C07C1/00; C07H19/20; (IPC1-7): C07H19/20; A61K31/7076
Domestic Patent References:
| WO1996015234A2 | 1996-05-23 |
Foreign References:
| EP0219829A2 | 1987-04-29 | |||
| US5512671A | 1996-04-30 |
Other References:
MONTGOMERY J A ET AL: "SYNTHESIS AND BIOLOGIC ACTIVITY OF 2'-FLUORO-2-HALO DERIVATIVES OF 9-BETA-D-ARABINOFURANOSYLADENINE", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 35, no. 2, 1992, pages 397 - 401, XP001097267, ISSN: 0022-2623
ZAITSEVA G V ET AL: "Convergent syntheses and cytostatic properties of 2-chloro-2'-deoxy-2'-fluoroadenosine and its N<7>-isomer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 5, no. 24, 21 December 1995 (1995-12-21), pages 2999 - 3002, XP004135146, ISSN: 0960-894X
MARUYAMA TOKUMI ET AL: "Synthesis and anti-HIV activity of 2-substituted 2'-deoxy-2'-fluoroadenosines", NUCLEOSIDES AND NUCLEOTIDES, vol. 13, no. 6-7, 1994, pages 1219 - 1230, XP009042788, ISSN: 0732-8311
ZAITSEVA G V ET AL: "Convergent syntheses and cytostatic properties of 2-chloro-2'-deoxy-2'-fluoroadenosine and its N<7>-isomer", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 5, no. 24, 21 December 1995 (1995-12-21), pages 2999 - 3002, XP004135146, ISSN: 0960-894X
MARUYAMA TOKUMI ET AL: "Synthesis and anti-HIV activity of 2-substituted 2'-deoxy-2'-fluoroadenosines", NUCLEOSIDES AND NUCLEOTIDES, vol. 13, no. 6-7, 1994, pages 1219 - 1230, XP009042788, ISSN: 0732-8311
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