Title:
NUCLEOTIDE SEQUENCES WHICH CODE FOR THE METF GENE
Document Type and Number:
WIPO Patent Application WO2002010206
Kind Code:
A3
Abstract:
The invention relates to an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70 % to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID No. 2, c) polynucleotide which is complementary to the polynucleotides of a) or b), and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acids using coryneform bacteria in which at least the metF gene is present in enhanced form, and the use of the polynucleotide sequences as hybridization probes.
Inventors:
BATHE BRIGITTE
MOECKEL BETTINA
PFEFFERLE WALTER
HUTHMACHER KLAUS
BINDER MICHAEL
GREISSINGER DIETER
THIERBACH GEORG
MOECKEL BETTINA
PFEFFERLE WALTER
HUTHMACHER KLAUS
BINDER MICHAEL
GREISSINGER DIETER
THIERBACH GEORG
Application Number:
PCT/EP2001/008224
Publication Date:
May 02, 2002
Filing Date:
July 17, 2001
Export Citation:
Assignee:
DEGUSSA (DE)
International Classes:
A23K1/00; A23K1/16; C07K14/34; C12N1/21; C12N9/06; C12P13/12; (IPC1-7): C07K14/34; A23L1/305; C12N1/21; C12N9/06; C12N15/10; C12N15/63; C12P13/08; C12Q1/68
Domestic Patent References:
| WO1993017112A1 | 1993-09-02 | |||
| WO1988009819A2 | 1988-12-15 |
Foreign References:
| EP0358940A1 | 1990-03-21 | |||
| EP0387527A1 | 1990-09-19 |
Other References:
DATABASE WPI Section Ch Week 200114, Derwent World Patents Index; Class B04, AN 2001-137957, XP002186601
DATABASE WPI Section Ch Week 199332, Derwent World Patents Index; Class B05, AN 1993-256072, XP002186165
BLANCO JORGE ET AL: "The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: Disruption of the 5,10-methylenetetrahydrofol ate reductase gene leads to methionine auxotrophy.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 6, March 1998 (1998-03-01), pages 1586 - 1591, XP002191540, ISSN: 0021-9193
OLD I G ET AL: "PHYSICAL MAPPING OF THE SCATTERED METHIONINE GENES ON THE ESCHERICHIA COLI CHROMOSOME", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 175, no. 11, June 1993 (1993-06-01), pages 3689 - 3691, XP001037964, ISSN: 0021-9193
KRAMER R: "Genetic and physiological approaches for the production of amino acids", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 45, no. 1, 12 February 1996 (1996-02-12), pages 1 - 21, XP004036833, ISSN: 0168-1656
DATABASE WPI Section Ch Week 199332, Derwent World Patents Index; Class B05, AN 1993-256072, XP002186165
BLANCO JORGE ET AL: "The folate branch of the methionine biosynthesis pathway in Streptomyces lividans: Disruption of the 5,10-methylenetetrahydrofol ate reductase gene leads to methionine auxotrophy.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 6, March 1998 (1998-03-01), pages 1586 - 1591, XP002191540, ISSN: 0021-9193
OLD I G ET AL: "PHYSICAL MAPPING OF THE SCATTERED METHIONINE GENES ON THE ESCHERICHIA COLI CHROMOSOME", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 175, no. 11, June 1993 (1993-06-01), pages 3689 - 3691, XP001037964, ISSN: 0021-9193
KRAMER R: "Genetic and physiological approaches for the production of amino acids", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 45, no. 1, 12 February 1996 (1996-02-12), pages 1 - 21, XP004036833, ISSN: 0168-1656
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