Title:
OCT3 ACTIVITY INHIBITOR CONTAINING IMIDAZOPYRIDINE DERIVATIVE AS ACTIVE COMPONENT, AND OCT3 DETECTION AGENT
Document Type and Number:
WIPO Patent Application WO/2014/103801
Kind Code:
A1
Abstract:
[Problem] To provide an OCT3 activity inhibitor having a different basic skeleton than that of conventional OCT3 activity inhibitors. [Solution] This inhibitor of organic cation transporter 3 (OCT3) contains, as an active component, an imidazo[1,2-a]pyridine derivative, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof
Inventors:
YAMASHITA HIDETOSHI (JP)
SUZUKI NOBUYUKI (JP)
SUZUKI NOBUYUKI (JP)
Application Number:
PCT/JP2013/083759
Publication Date:
July 03, 2014
Filing Date:
December 17, 2013
Export Citation:
Assignee:
SHIN NIPPON BIOMEDICAL LAB LTD (JP)
International Classes:
A61K31/437; A61K31/444; A61K31/4453; A61K31/496; A61P25/24; A61P43/00; G01N33/68; C07D471/04
Domestic Patent References:
| WO2009134877A2 | 2009-11-05 | |||
| WO2005084707A1 | 2005-09-15 | |||
| WO2009134877A2 | 2009-11-05 | |||
| WO2001093863A2 | 2001-12-13 |
Foreign References:
| JP2009541473A | 2009-11-26 | |||
| JP2011509251A | 2011-03-24 | |||
| US20070136828A1 | 2007-06-14 | |||
| US6403645B2 | 2002-06-11 | |||
| JPH0664060B2 | 1994-08-22 |
Other References:
HAO-JIE ZHU ET AL.: "Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action", PHARMACOL RES., vol. 5, no. 4, pages 491 - 6, XP055268293
NIES, HANDB EXP PHARMACOL., vol. 201, 2011, pages 105 - 167
SATA, J PHARMACOL EXP THER., vol. 315, 2005, pages 888 - 895
"Remington's Pharmaceutical Sciences, 17th ed.,", 1985, MACK PUBLISHING COMPANY, pages: 1418
KITAICHI ET AL., NEUROSCI LETT., vol. 382, no. 1-2, 1 July 2005 (2005-07-01), pages 195 - 200
BR J PHARMACOL., vol. 136, no. 6, 2002, pages 829 - 836
J BIOL CHEM., vol. 193, no. 1, 1951, pages 265 - 75
PRABHA ET AL.: "In Silico Modeling for Blood-Brain Barrier Permeability Predictions", DRUG ABSORPTION STUDIES, vol. VII, no. 3, 2008, pages 510 - 556
PORSOLT RD, ARCH INT PHARMACODYN, vol. 229, 1977, pages 327 - 336
MINORU TSUJI ET AL., JAPANESE PHARMACOLOGICAL MAGAZINE, vol. 130, 2007, pages 97 - 104
YUTAKA NAKAGAWA: "practice behavioral pharmacology", KINPODO, 2010, pages 35 - 42
KITAICHI. ET AL., NEUROSCI LETT., vol. 382, no. 1-2, 1 July 2005 (2005-07-01), pages 195 - 200
J. CHEM. NEUROANAT., vol. 20, 2000, pages 375 - 87
NIES, HANDB EXP PHARMACOL., vol. 201, 2011, pages 105 - 167
SATA, J PHARMACOL EXP THER., vol. 315, 2005, pages 888 - 895
"Remington's Pharmaceutical Sciences, 17th ed.,", 1985, MACK PUBLISHING COMPANY, pages: 1418
KITAICHI ET AL., NEUROSCI LETT., vol. 382, no. 1-2, 1 July 2005 (2005-07-01), pages 195 - 200
BR J PHARMACOL., vol. 136, no. 6, 2002, pages 829 - 836
J BIOL CHEM., vol. 193, no. 1, 1951, pages 265 - 75
PRABHA ET AL.: "In Silico Modeling for Blood-Brain Barrier Permeability Predictions", DRUG ABSORPTION STUDIES, vol. VII, no. 3, 2008, pages 510 - 556
PORSOLT RD, ARCH INT PHARMACODYN, vol. 229, 1977, pages 327 - 336
MINORU TSUJI ET AL., JAPANESE PHARMACOLOGICAL MAGAZINE, vol. 130, 2007, pages 97 - 104
YUTAKA NAKAGAWA: "practice behavioral pharmacology", KINPODO, 2010, pages 35 - 42
KITAICHI. ET AL., NEUROSCI LETT., vol. 382, no. 1-2, 1 July 2005 (2005-07-01), pages 195 - 200
J. CHEM. NEUROANAT., vol. 20, 2000, pages 375 - 87
Attorney, Agent or Firm:
HIROSE TAKAYUKI (JP)
Takayuki Hirose (JP)
Takayuki Hirose (JP)
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