Title:
OCTOPUS-DERIVED PEPTIDE OCTOPROMYCIN HAVING ANTIBACTERIAL AND ANTI-BIOFILM ACTIVITY AGAINST ACINETOBACTER BAUMANNII
Document Type and Number:
WIPO Patent Application WO/2022/039544
Kind Code:
A1
Abstract:
The present invention relates to octopromycin, which is a synthetic peptide having excellent antibacterial activity against Acinetobacter sp. bacteria, and an antibacterial composition comprising octopromycin as an active ingredient. Octopromycin or a fragment thereof according to the present invention exhibits high inhibitory effects on the growth and biofilm formation of Acinetobacter baumannii, which is a multi-drug resistant bacterium causing nosocomial infection, in addition to being free of cytotoxicity, thus finding advantageous applications in treating and preventing the infection of Acinetobacter baumannii.
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Inventors:
WHANG IL SON (KR)
DEZOYSA MAHANAMA (KR)
RAJAPAKSHA PATHIRANAGE DINUSHA CATHURANGI (KR)
NIKAPITIYA CHAMILANI LALANTHI (KR)
DEZOYSA MAHANAMA (KR)
RAJAPAKSHA PATHIRANAGE DINUSHA CATHURANGI (KR)
NIKAPITIYA CHAMILANI LALANTHI (KR)
Application Number:
PCT/KR2021/011092
Publication Date:
February 24, 2022
Filing Date:
August 20, 2021
Export Citation:
Assignee:
NAT MARINE BIODIVERSITY INSTITUTE OF KOREA (KR)
International Classes:
C07K14/435; A61K38/00; A61P31/04
Domestic Patent References:
| WO2005108576A1 | 2005-11-17 |
Foreign References:
| KR20200047329A | 2020-05-07 | |||
| KR102262261B1 | 2021-06-08 |
Other References:
DATABASE PROTEIN 9 December 2015 (2015-12-09), ANONYMOUS: "PREDICTED: proline-rich protein 5-like [Octopus bimaculoides]", XP055901458, retrieved from GENBANK Database accession no. XP_014789329
MARDIROSSIAN MARIO, SOLA RICCARDO, DEGASPERI MARGHERITA, SCOCCHI MARCO: "Search for Shorter Portions of the Proline‐Rich Antimicrobial Peptide Fragment Bac5(1–25) That Retain Antimicrobial Activity by Blocking Protein Synthesis", CHEMMEDCHEM COMMUNICATIONS, vol. 14, no. 3, 5 February 2019 (2019-02-05), DE , pages 343 - 348, XP055901476, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800734
RAJAPAKSHA D.C.; JAYATHILAKA E.H.T. THULSHAN; EDIRISINGHE S.L.; NIKAPITIYA CHAMILANI; LEE JOEUN; WHANG ILSON; DE ZOYSA MAHANAMA: "Octopromycin: Antibacterial and antibiofilm functions of a novel peptide derived from Octopus minor against multidrug-resistant Acinetobacter baumannii", FISH & SHELLFISH IMMUNOLOGY, vol. 117, 23 July 2021 (2021-07-23), GB , pages 82 - 94, XP086759551, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2021.07.019
MARDIROSSIAN MARIO, SOLA RICCARDO, DEGASPERI MARGHERITA, SCOCCHI MARCO: "Search for Shorter Portions of the Proline‐Rich Antimicrobial Peptide Fragment Bac5(1–25) That Retain Antimicrobial Activity by Blocking Protein Synthesis", CHEMMEDCHEM COMMUNICATIONS, vol. 14, no. 3, 5 February 2019 (2019-02-05), DE , pages 343 - 348, XP055901476, ISSN: 1860-7179, DOI: 10.1002/cmdc.201800734
RAJAPAKSHA D.C.; JAYATHILAKA E.H.T. THULSHAN; EDIRISINGHE S.L.; NIKAPITIYA CHAMILANI; LEE JOEUN; WHANG ILSON; DE ZOYSA MAHANAMA: "Octopromycin: Antibacterial and antibiofilm functions of a novel peptide derived from Octopus minor against multidrug-resistant Acinetobacter baumannii", FISH & SHELLFISH IMMUNOLOGY, vol. 117, 23 July 2021 (2021-07-23), GB , pages 82 - 94, XP086759551, ISSN: 1050-4648, DOI: 10.1016/j.fsi.2021.07.019
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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