Title:
ODORANT RECEPTOR CO-RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2018/062203
Kind Code:
A1
Abstract:
The present invention provides an insect odorant receptor co-receptor that exhibits excellent detection sensitivity of odorants when bound with an odorant receptor to form an odorant receptor complex. This odorant receptor co-receptor is provided with the following first amino acid sequence and second amino acid sequence which follows the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence: (1) a first amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the receptor, and which is an amino acid sequence that is continuous from the amino-terminal of the first insect odorant receptor co-receptor or the variant thereof to any amino acid residue positioned in the range of 20 amino acid residues before and after the amino acid residue furthest on the carboxyl-terminal side in the fourth transmembrane domain; and (2) a second amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a different variety than the first insect or a variant of the receptor, and which, in an alignment analysis of the amino acid sequence of the first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, is an amino acid sequence that is continuous from one carboxyl-terminal-side amino acid residue, said residue being in a position in the second insect odorant receptor co-receptor or the variant thereof that corresponds to the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence, to the carboxyl-terminal of the second insect odorant receptor co-receptor or the variant thereof.
Inventors:
TAKAHASHI YASUHIKO (JP)
TAKAKU TOMOYUKI (JP)
TAKAKU TOMOYUKI (JP)
Application Number:
PCT/JP2017/034792
Publication Date:
April 05, 2018
Filing Date:
September 26, 2017
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
International Classes:
C12N15/09; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Foreign References:
| JP2005510209A | 2005-04-21 | |||
| JP2015192664A | 2015-11-05 | |||
| US20040235060A1 | 2004-11-25 |
Other References:
DATABASE Database UniPro t UNIPROTKB; 16 April 2014 (2014-04-16), XP055495751, Database accession no. W6GTH2
MELO, ANA CLAUDIA A. ET AL.: "Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs", CHEM. SENSES, vol. 29, no. 1, 2004, pages 403 - 410, XP055495753, ISSN: 1464-3553
MUELLER, KATHARINA ET AL.: "Chimeric FLS2 receptors reveal the basis for differential flagellin perception in Arabidopsis and tomato", PLANT CELL, vol. 24, no. 5, 2012, pages 2213 - 2224, XP055495760, ISSN: 1040-4651
HOPE, ANTHONY G. ET AL.: "Molecular determinants of (+)-tubocurarine binding at recombinant 5-hydroxytryptamine3A receptor subunits", MOL. PHARMACOL., vol. 55, 1999, pages 1037 - 1043, XP055495763, ISSN: 1521-0111
FUKUTANI, YOSUKE ET AL.: "The N-terminal replacement of an olfactory receptor for the development of a Yeast-based biomimetic odor sensor", BIOTECHNOL . BIOENG., vol. 109, 2012, pages 205 - 212, XP055495766, ISSN: 1097-0290
See also references of EP 3521427A4
MELO, ANA CLAUDIA A. ET AL.: "Identification of a chemosensory receptor from the yellow fever mosquito, Aedes aegypti, that is highly conserved and expressed in olfactory and gustatory organs", CHEM. SENSES, vol. 29, no. 1, 2004, pages 403 - 410, XP055495753, ISSN: 1464-3553
MUELLER, KATHARINA ET AL.: "Chimeric FLS2 receptors reveal the basis for differential flagellin perception in Arabidopsis and tomato", PLANT CELL, vol. 24, no. 5, 2012, pages 2213 - 2224, XP055495760, ISSN: 1040-4651
HOPE, ANTHONY G. ET AL.: "Molecular determinants of (+)-tubocurarine binding at recombinant 5-hydroxytryptamine3A receptor subunits", MOL. PHARMACOL., vol. 55, 1999, pages 1037 - 1043, XP055495763, ISSN: 1521-0111
FUKUTANI, YOSUKE ET AL.: "The N-terminal replacement of an olfactory receptor for the development of a Yeast-based biomimetic odor sensor", BIOTECHNOL . BIOENG., vol. 109, 2012, pages 205 - 212, XP055495766, ISSN: 1097-0290
See also references of EP 3521427A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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