Title:
OLANZAPINE TRANSDERMAL ADMINISTRATION SYSTEM, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/134641
Kind Code:
A1
Abstract:
The present invention relates to an olanzapine transdermal administration system, and a preparation method therefor and the use thereof. Olanzapine or a pharmaceutically acceptable salt thereof in the transdermal administration system is dispersed in an amorphous state in a matrix layer, which can realize stable drug release.
Inventors:
TANG JIANSHENG (CN)
Application Number:
PCT/CN2023/071410
Publication Date:
July 20, 2023
Filing Date:
January 09, 2023
Export Citation:
Assignee:
NOVASTAGE PHARMACEUTICALS SHENZHEN LTD (CN)
International Classes:
A61K9/70; A61K9/00; A61K31/551; A61K31/5513; A61K47/12; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/40; A61K47/44; A61P25/18; A61P25/22
Domestic Patent References:
| WO2022066987A1 | 2022-03-31 |
Foreign References:
| US20220040194A1 | 2022-02-10 | |||
| US20210244679A1 | 2021-08-12 |
Other References:
AGGARWAL GEETA, DHAWAN SANJU, L. HARIKUMAR S.: "Natural Oils as Skin Permeation Enhancers for Transdermal Delivery of Olanzapine: In Vitro and In Vivo Evaluation", CURRENT DRUG DELIVERY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, vol. 9, no. 2, 1 March 2012 (2012-03-01), NL , pages 172 - 181, XP055872569, ISSN: 1567-2018, DOI: 10.2174/156720112800234567
LI NING; QUAN PENG; WAN XIAOCAO; LIU CHAO; LIU XIAOCHANG; FANG LIANG: "Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 107, 8 July 2017 (2017-07-08), NL , pages 138 - 147, XP085151551, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2017.07.006
ZHIRONG LI, CHEN YONGSHUN, DU SHIMING, JIANG HUAJUN: "Effect of Matrixes and Different Penetration Enhancers on Transdermal Permeability of Olanzapine in vitro", CHINA PHARMACIST, vol. 16, no. 7, 5 July 2013 (2013-07-05), pages 1017 - 1020, XP093078691
MENG-SI LIU, HAN HONG-CAN; SUN CHUN-MENG;: "The application of non-oral modified release preparation in the treatment of schizophrenia and general consideration for its research and development", THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 37, no. 10, 28 May 2021 (2021-05-28), pages 1255 - 1265, XP093078693
LI NING; QUAN PENG; WAN XIAOCAO; LIU CHAO; LIU XIAOCHANG; FANG LIANG: "Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 107, 8 July 2017 (2017-07-08), NL , pages 138 - 147, XP085151551, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2017.07.006
ZHIRONG LI, CHEN YONGSHUN, DU SHIMING, JIANG HUAJUN: "Effect of Matrixes and Different Penetration Enhancers on Transdermal Permeability of Olanzapine in vitro", CHINA PHARMACIST, vol. 16, no. 7, 5 July 2013 (2013-07-05), pages 1017 - 1020, XP093078691
MENG-SI LIU, HAN HONG-CAN; SUN CHUN-MENG;: "The application of non-oral modified release preparation in the treatment of schizophrenia and general consideration for its research and development", THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY, vol. 37, no. 10, 28 May 2021 (2021-05-28), pages 1255 - 1265, XP093078693
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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