Title:
OLAPARIB DISSOLUTION ENHANCING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/175274
Kind Code:
A1
Abstract:
An olaparib dissolution enhancing composition, a preparation method therefor, a use thereof, and a medicament comprising the olaparib dissolution enhancing composition. The olaparib dissolution enhancing composition comprises: 100 parts by weight of olaparib, greater than 100 parts by weight and less than 200 parts by weight of copovidone, and 20 to150 parts by weight of a dissolution promoter. The olaparib dissolution enhancing composition and the medicament prepared therefrom are controllable in stability, oral absorption of active ingredients can be improved, the dosage of adjuvant materials is reduced, medication convenience of patients is increased, and industrial production is facilitated.
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Inventors:
GAN YONG (CN)
GUO SHIYAN (CN)
AN WEI (CN)
GUO SHIYAN (CN)
AN WEI (CN)
Application Number:
PCT/CN2021/078978
Publication Date:
September 10, 2021
Filing Date:
March 04, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K9/20; A61K31/502; A61K47/32; A61K47/40; A61P35/00
Foreign References:
| CN102238945A | 2011-11-09 | |||
| CN109381438A | 2019-02-26 | |||
| CN108201536A | 2018-06-26 | |||
| EP3263095A1 | 2018-01-03 | |||
| CN104434809A | 2015-03-25 | |||
| CN106265580A | 2017-01-04 |
Other References:
HALLAM CATHERINE N., GABBOTT IAN P.: "Increasing tensile strength by reducing particle size for extrudate-based tablet formulations", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, ED. DE SANTÉ, FR, vol. 52, 1 August 2019 (2019-08-01), FR, pages 825 - 830, XP055842817, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2019.05.049
SENRA JOANA M., TELFER BRIAN A., CHERRY KIM E., MCCRUDDEN CIAN M., HIRST DAVID G., O'CONNOR MARK J., WEDGE STEPHEN R., STRATFORD I: "Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 10, 1 October 2011 (2011-10-01), US, pages 1949 - 1958, XP055842818, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-11-0278
LAN, SHUN: "Research Progress in Methods to Improve the Dissolution of Poorly Soluble Pharmaceutical Solid Preparations", STRAIT PHARMACEUTICAL JOURNAL, vol. 16, no. 3, 30 June 2004 (2004-06-30), pages 28 - 31, XP055842820
SENRA JOANA M., TELFER BRIAN A., CHERRY KIM E., MCCRUDDEN CIAN M., HIRST DAVID G., O'CONNOR MARK J., WEDGE STEPHEN R., STRATFORD I: "Inhibition of PARP-1 by Olaparib (AZD2281) Increases the Radiosensitivity of a Lung Tumor Xenograft", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 10, no. 10, 1 October 2011 (2011-10-01), US, pages 1949 - 1958, XP055842818, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-11-0278
LAN, SHUN: "Research Progress in Methods to Improve the Dissolution of Poorly Soluble Pharmaceutical Solid Preparations", STRAIT PHARMACEUTICAL JOURNAL, vol. 16, no. 3, 30 June 2004 (2004-06-30), pages 28 - 31, XP055842820
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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