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Title:
OLGIONUCLEOTIDE AND ARTIFICIAL NUCLEOSIDE HAVING GUANIDINE BRIDGE
Document Type and Number:
WIPO Patent Application WO/2014/046212
Kind Code:
A1
Abstract:
 This oligonucleotide or pharmaceutically acceptable salt thereof contains a compound represented by formula I or II or a salt thereof, and at least one nucleoside structure represented by formula I' or II'. Thus provided is a nucleic acid molecule for oligonucleotides having high specificity and binding affinity to a target nucleic acid, and exhibiting high nuclease resistance.

Inventors:
OBIKA, Satoshi (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
KOTOBUKI, Yutaro (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
WAKI, Reiko (1-1 Yamadaoka, Suita-sh, Osaka 71, 〒5650871, JP)
Application Number:
JP2013/075370
Publication Date:
March 27, 2014
Filing Date:
September 19, 2013
Export Citation:
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Assignee:
OSAKA UNIVERSITY (1-1 Yamadaoka, Suita-shi Osaka, 71, 〒5650871, JP)
International Classes:
C07H19/06; C07H19/16; C07H21/02; C12N15/00
Domestic Patent References:
WO2011052436A12011-05-05
WO2003068795A12003-08-21
WO2007026824A12007-03-08
WO1998039352A11998-09-11
WO2005021570A12005-03-10
WO2003068795A12003-08-21
WO2011052436A12011-05-05
Other References:
YUTARO KOTOBIKI ET AL., ANTISENSE DNA/RNA KENKYUKAI IDENSHI DELIVERY KENKYUKAI ANTISENSE IDENSHI DELIVERY SYMPOSIUM 2012 YOSHISHU, 24 September 2012 (2012-09-24), pages 25, XP008178648
MASARU NISHIDA ET AL.: "- SYNTHESIS, RNA SELECTIVE HYBRIDIZATION AND HIGH NUCLEASE RESISTANCE OF AN OLIGONUCLEOTIDE CONTAINING NOVEL BRIDGED NUCLEIC ACID WITH CYCLIC UREA STRUCTURE", CHEMICAL COMMUNICATIONS, vol. 46, no. 29, 7 August 2010 (2010-08-07), pages 5283 - 5285, XP055082026
KAZUYUKI MIYASHITA ET AL.: "N-METHYL SUBSTITUTED 2',4'-BNANC: A HIGHLY NUCLEASE-RESISTANT NUCLEIC ACID ANALOGUE WITH HIGH-AFFINITY RNA SELECTIVE HYBRIDIZATION PUB - CHEMICAL COMMUNICATIONS,", CHEMICAL COMMUNICATIONS, vol. 36, 28 September 2007 (2007-09-28), pages 3765 - 3767, XP055031786
MASAYASU KUWAHARA ET AL., KAGAKU KOGYO, vol. 63, no. 1, 1 January 2012 (2012-01-01), pages 42 - 48, XP008178644
TAKESHI IMANISHI ET AL.: "SYNTHESES AND PROPERTIES OF NOVEL CONFORMATIONALLY RESTRAINED NUCLEOSIDE ANALOGUES", J. SYNTH. ORG. CHEM., vol. 57, no. 11, November 1999 (1999-11-01), JPN., pages 969 - 980, XP008178664
See also references of EP 2899197A4
C. WAHLESTEDT ET AL., PROC. NATL. ACAD. SCI. USA, vol. 97, no. 10, 2000, pages 5633 - 5638
Y. HARI ET AL., BIOORG. MED. CHEM., vol. 14, 2006, pages 1029 - 1038
K. MIYASHITA ET AL., CHEM. COMMUN., 2007, pages 3765 - 3767
S.M.A. RAHMAN ET AL., J. AM. CHEM. SOC., vol. 130, no. 14, 2008, pages 4886 - 4896
M. KUWAHARA ET AL., NUCLEIC ACIDS RES., vol. 36, no. 13, 2008, pages 4257 - 4265
S. OBIKA ET AL., BIOORG. MED. CHEM., vol. 9, 2001, pages 1001 - 1011
NISHIDA, M. ET AL., CHEM. COMMUN., vol. 46, 2010, pages 5283 - 5285
SHRESTHA, A.R. ET AL., J. ORG. CHEM., vol. 76, 2011, pages 9891 - 9899
NUCLEIC ACIDS RESEARCH, vol. 36, 2008, pages 2764 - 2776
Attorney, Agent or Firm:
SHINDO, Takuya et al. (5th Floor, Okina Bldg. 2-9, Nishitenma 3-chome, Kita-ku, Osaka-sh, Osaka 47, 〒5300047, JP)
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