Title:
OLIGO-NUCLEIC ACID NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2023/195527
Kind Code:
A1
Abstract:
The purpose of the present invention is to increase the amount of oligo-nucleic acid transported into a cytoplasm by bringing about an efficient interaction of a cell uptake promoter with a target cell. An oligo-nucleic acid nanoparticle according to one aspect of the present invention comprises: a core constituted by a dendritic polymer; a plurality of oligo-nucleic acids bonded to the core; one or a plurality of hydrophilic polymers bonded to the plurality of oligo-nucleic acids; and one or a plurality of cell uptake promoters bonded to the one or plurality of hydrophilic polymers. The bonds between the core and the oligo-nucleic acids, the bonds between the oligo-nucleic acids and the hydrophilic polymer(s), and the bonds between the hydrophilic polymer(s) and the cell uptake promoter(s) are each independently direct bonds or bonds facilitated by a linker. The cell uptake promoter is located on the surface of the oligo-nucleic acid nanoparticle.
Inventors:
MAKITA NAOKI (JP)
UESAKA AKIHIRO (JP)
UESAKA AKIHIRO (JP)
Application Number:
PCT/JP2023/014288
Publication Date:
October 12, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
SUMITOMO PHARMA CO LTD (JP)
International Classes:
A61K9/14; A61K31/713; A61K47/34; A61K47/42; A61K47/56; A61K47/59; A61K47/60; A61K47/62; A61K47/65; A61K47/68; A61P3/00; A61P21/00; A61P25/00; A61P29/00; A61P31/00; A61P35/00; A61P37/06; B82Y5/00; B82Y40/00; C12N15/113; C12N15/87
Domestic Patent References:
| WO2013062982A1 | 2013-05-02 | |||
| WO2022075459A1 | 2022-04-14 |
Other References:
IN-HYUN LEE; SUKYUNG AN; MI KYUNG YU; HO-KEUN KWON; SIN-HYEOG IM; SANGYONG JON;: "Targeted chemoimmunotherapy using drug-loaded aptamer dendrimer bioconjugates", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 155, no. 3, 22 May 2011 (2011-05-22), AMSTERDAM, NL , pages 435 - 441, XP028317073, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2011.05.025
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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