Title:
OLIGOMER EXTENDED INSULIN-FC CONJUGATES
Document Type and Number:
WIPO Patent Application WO/2018/185131
Kind Code:
A3
Abstract:
This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.
Inventors:
TAGMOSE TINA (DK)
MADSEN PETER (DK)
KJELDSEN THOMAS (DK)
PRIDAL LONE (DK)
DE MARIA LEONARDO (DK)
LIN ZHAOSHENG (CN)
WAN ZHE (CN)
ZHANG YUANYUAN (CN)
LYKKE LENNART (DK)
MÜNZEL MARTIN (DK)
KODRA JÁNOS (DK)
MADSEN PETER (DK)
KJELDSEN THOMAS (DK)
PRIDAL LONE (DK)
DE MARIA LEONARDO (DK)
LIN ZHAOSHENG (CN)
WAN ZHE (CN)
ZHANG YUANYUAN (CN)
LYKKE LENNART (DK)
MÜNZEL MARTIN (DK)
KODRA JÁNOS (DK)
Application Number:
PCT/EP2018/058550
Publication Date:
November 15, 2018
Filing Date:
April 04, 2018
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
International Classes:
A61K47/68; A61K47/64; A61P5/50; A61K38/28
Domestic Patent References:
| WO2016193380A1 | 2016-12-08 | |||
| WO2008049711A1 | 2008-05-02 | |||
| WO2016178905A1 | 2016-11-10 | |||
| WO2011122921A2 | 2011-10-06 | |||
| WO2016133372A2 | 2016-08-25 | |||
| WO2017031034A2 | 2017-02-23 | |||
| WO2011059684A1 | 2011-05-19 | |||
| WO2009053368A1 | 2009-04-30 | |||
| WO2017055582A1 | 2017-04-06 |
Foreign References:
| US20160000932A1 | 2016-01-07 | |||
| US20060276633A1 | 2006-12-07 |
Download PDF: