Title:
OLIGOMERIC COMPOUNDS HAVING MODIFIED PHOSPHATE GROUPS
Document Type and Number:
WIPO Patent Application WO2003087115
Kind Code:
B1
Abstract:
Oligomeric compounds having at least one phosphorothioate monoester are provided having increased nuclease resistance and binding affinity to a complementary strand of nucleic acid. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions responsive to oligonucleotide therapeutics.
Inventors:
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
Application Number:
PCT/US2003/010840
Publication Date:
December 16, 2004
Filing Date:
April 09, 2003
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
RAVIKUMAR VASULINGA (US)
PRAKASH THAZHA P (US)
BHAT BALKRISHEN (US)
International Classes:
C07H21/00; C12N5/02; C12N15/113; A61K38/00; (IPC1-7): A61K48/00; C07H21/04
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