Title:
OLIGONUCLEOTIDE ANALOGS
Document Type and Number:
WIPO Patent Application WO/2007/026824
Kind Code:
A1
Abstract:
An oligonucleotide analog containing a nucleoside analog represented by the
following general formula (I): [Chemical formula 1] wherein R1 to
R4 independently represent each H or a group selected from optionally
substituted C1-4 alkyl, halogen, OH, C1-4 alkyl-OH, C1-4
alkyl-O-C1-4 alkyl, NH2, NO2, N(C1-4
alkyl)2, O-C1-4 alkyl, COOH, SH, SO3H, C1-5
acyl, C2-5 alkenyl, C2-5 alkynyl, C3-8 cycloalkyl,
C6-10 aryl and C7-10 aralkyl; a method of detecting a target
duplex DNA sequence in a sample by using the above oligonucleotide analog; a method
of forming a triplex with a target duplex DNA; and a medicinal composition containing
the above oligonucleotide analog.
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Inventors:
OBIKA SATOSHI (JP)
IMANISHI TAKESHI (JP)
IMANISHI TAKESHI (JP)
Application Number:
PCT/JP2006/317224
Publication Date:
March 08, 2007
Filing Date:
August 31, 2006
Export Citation:
Assignee:
UNIV OSAKA (JP)
OBIKA SATOSHI (JP)
IMANISHI TAKESHI (JP)
OBIKA SATOSHI (JP)
IMANISHI TAKESHI (JP)
International Classes:
C07H21/04; A61K31/712; A61P43/00
Domestic Patent References:
| WO2002018388A1 | 2002-03-07 | |||
| WO2003068795A1 | 2003-08-21 |
Other References:
OBIKA S. ET AL.: "Triplex formation by an oligonucleotide containing conformationally locked C-nucleotide, 5-(2-O,4-C-methylene-beta-D-ribofuranosyl)oxazole", TETRAHEDRON LETTERS, vol. 41, 2000, pages 221 - 224, XP004185452
HARI Y. ET AL.: "Effective synthesis of C-nucleosides with 2', 4'-BNA modification", TETRAHEDRON, vol. 58, 2002, pages 3051 - 3063, XP004347800
OBIKA S. ET AL.: "Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system", TETRAHEDRON LETTERS, vol. 41, 2000, pages 215 - 219, XP004185451
OBIKA S. ET AL.: "A 2',4'-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C.G Interruption by Triplex Formation with a Pyrimidine Motif", ANGEW. CHEM. INT. ED., vol. 40, no. 11, 2001, pages 2079 - 2081, XP002902765
HARI Y. ET AL.: "Effective synthesis of C-nucleosides with 2', 4'-BNA modification", TETRAHEDRON, vol. 58, 2002, pages 3051 - 3063, XP004347800
OBIKA S. ET AL.: "Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system", TETRAHEDRON LETTERS, vol. 41, 2000, pages 215 - 219, XP004185451
OBIKA S. ET AL.: "A 2',4'-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C.G Interruption by Triplex Formation with a Pyrimidine Motif", ANGEW. CHEM. INT. ED., vol. 40, no. 11, 2001, pages 2079 - 2081, XP002902765
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 01, JP)
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