Title:
OLIGONUCLEOTIDE-BASED INHIBITORS COMPRISING LOCKED NUCLEIC ACID MOTIF
Document Type and Number:
WIPO Patent Application WO/2013/192576
Kind Code:
A3
Abstract:
The present invention relates to chemical modification motifs for oligonucleotides. The oligonucleotides of the present invention, such as chemically modified antisense oligonucleotides, can have increased in vivo efficacy. The chemically modified oligonucleotides provide advantages in one or more of potency, efficiency of delivery, target specificity, toxicity, and/or stability. The chemically modified oligonucleotides have a specific chemical modification motif or pattern of locked nucleic acids (LNAs). The oligonucleotide (e.g. antisense oligonucleotide) can target RNA, such as miRNA or mRNA. Also provided herein are compositions comprising the chemically modified oligonucleotides and methods of using the chemically modified oligonucleotides as therapeutics for various disorders, including cardiovascular disorders.
Inventors:
VAN ROOIJ EVA (NL)
DALBY CHRISTINA M (US)
MONTGOMERY RUSTY L (US)
DALBY CHRISTINA M (US)
MONTGOMERY RUSTY L (US)
Application Number:
PCT/US2013/047157
Publication Date:
April 03, 2014
Filing Date:
June 21, 2013
Export Citation:
Assignee:
MIRAGEN THERAPEUTICS (US)
International Classes:
C12N15/113; A61K31/7115; A61K48/00
Domestic Patent References:
| WO2010000665A1 | 2010-01-07 | |||
| WO2001025478A1 | 2001-04-12 | |||
| WO2012083005A2 | 2012-06-21 | |||
| WO2012061810A1 | 2012-05-10 | |||
| WO2012037254A1 | 2012-03-22 |
Foreign References:
| EP2194129A2 | 2010-06-09 |
Other References:
See also references of EP 2864482A4
Attorney, Agent or Firm:
MCLEOD, Bonnie Weiss et al. (1299 Pennsylvania Avenue NW,Suite 70, Washington District of Columbia, US)
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