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Patent Searching and Data


Title:
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/062862
Kind Code:
A8
Abstract:
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Inventors:
BUTLER, David Charles Donnell (733 Concord AvenueCambridge, Massachusetts, 02138, US)
DIVAKARAMENON, Sethumadhavan (733 Concord AvenueCambridge, Massachusetts, 02138, US)
FRANCIS, Christopher J. (733 Concord AvenueCambridge, Massachusetts, 02138, US)
FRANK-KAMENETSKY, Maria David (733 Concord AvenueCambridge, Massachusetts, 02138, US)
IWAMOTO, Naoki (733 Concord AvenueCambridge, Massachusetts, 02138, US)
LU, Genliang (733 Concord AvenueCambridge, Massachusetts, 02138, US)
MARAPPAN, Subramanian (733 Concord AvenueCambridge, Massachusetts, 02138, US)
Meena (733 Concord AvenueCambridge, Massachusetts, 02138, US)
VARGEESE, Chandra (733 Concord AvenueCambridge, Massachusetts, 02138, US)
VERDINE, Gregory L. (733 Concord AvenueCambridge, Massachusetts, 02138, US)
YANG, Hailin (733 Concord AvenueCambridge, Massachusetts, 02138, US)
ZHANG, Jason Jingxin (733 Concord AvenueCambridge, Massachusetts, 02138, US)
Application Number:
US2016/056123
Publication Date:
April 13, 2017
Filing Date:
October 07, 2016
Export Citation:
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Assignee:
WAVE LIFE SCIENCES LTD. (8 Cross Street, #10-00PWC Building, Singapore 4, 048424, SG)
BUTLER, David Charles Donnell (733 Concord AvenueCambridge, Massachusetts, 02138, US)
DIVAKARAMENON, Sethumadhavan (733 Concord AvenueCambridge, Massachusetts, 02138, US)
FRANCIS, Christopher J. (733 Concord AvenueCambridge, Massachusetts, 02138, US)
FRANK-KAMENETSKY, Maria David (733 Concord AvenueCambridge, Massachusetts, 02138, US)
IWAMOTO, Naoki (733 Concord AvenueCambridge, Massachusetts, 02138, US)
LU, Genliang (733 Concord AvenueCambridge, Massachusetts, 02138, US)
MARAPPAN, Subramanian (733 Concord AvenueCambridge, Massachusetts, 02138, US)
Meena (733 Concord AvenueCambridge, Massachusetts, 02138, US)
VARGEESE, Chandra (733 Concord AvenueCambridge, Massachusetts, 02138, US)
VERDINE, Gregory L. (733 Concord AvenueCambridge, Massachusetts, 02138, US)
YANG, Hailin (733 Concord AvenueCambridge, Massachusetts, 02138, US)
ZHANG, Jason Jingxin (733 Concord AvenueCambridge, Massachusetts, 02138, US)
International Classes:
C07C317/28; C07D295/088; C12N15/11; C12N15/113; C12Q1/68
Attorney, Agent or Firm:
LI, Xiaodong et al. (Choate, Hall & Stewart LLPTwo International Plac, Boston Massachusetts, 02110, US)
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