Title:
OLIGONUCLEOTIDE MODULATION OF CELL ADHESION
Document Type and Number:
WIPO Patent Application WO2004108945
Kind Code:
A3
Abstract:
Compositions and methods for the treatment of ophthalmic disorders, particularly preservation of corneal explants and prevention of corneal allograft rejection. These compositions comprise oligonucleotides which are specifically hybridizable with nucleic acids encoding the cellular adhesion molecules intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1).
Inventors:
BENNETT FRANK C (US)
MIRABELLI CHRISTOPHER K (US)
MIRABELLI CHRISTOPHER K (US)
Application Number:
PCT/US2004/013379
Publication Date:
November 17, 2005
Filing Date:
April 30, 2004
Export Citation:
Assignee:
ISIS PHARMACEUTICALS INC (US)
BENNETT FRANK C (US)
MIRABELLI CHRISTOPHER K (US)
BENNETT FRANK C (US)
MIRABELLI CHRISTOPHER K (US)
International Classes:
A01N43/04; A61K48/00; A61P1/16; A61P27/02; A61P29/00; A61P31/00; A61P31/14; A61P31/18; A61P35/00; A61P43/00; C07H21/02; C07H21/04; C12N5/22; C12N15/113; C12N15/12; C12N15/63; C12N15/88; C12P19/34; C12Q1/68; C12Q; (IPC1-7): C12Q1/68; A01N43/04; C07H21/02; C07H21/04; C12N15/63; C12N15/88; C12P19/34
Foreign References:
| US6506559B1 | 2003-01-14 | |||
| US6096722A | 2000-08-01 |
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