Title:
OLIGONUCLEOTIDES HAVING 6-THIO-2'-DEOXYGUANOSINE RESIDUES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/034853
Kind Code:
A3
Abstract:
The disclosure provides, inter alia, oligonucleotides comprising 6-thio-2'-deoxy-guanosine residues. The oligonucleotides comprising said residues are used in pharmaceutical compositions and methods for treating cancer. The invention also includes CpG oligodeoxynucleotides in combination with the 6-thio-2'-deoxy-guanosine residues in said pharmaceutical compositions and methods for treating cancer. Oligonucleotides of the invention may also include additional therapeutic moieties or exonuclease resistant moieties. The compositions and methods of the invention may employ additional pharmaceutical entities for the treatment of cancer.
Inventors:
KORTYLEWSKI MARCIN TOMASZ (US)
YU CHUNSONG (US)
SWIDERSKI PIOTR MAREK (US)
YU CHUNSONG (US)
SWIDERSKI PIOTR MAREK (US)
Application Number:
PCT/US2022/075745
Publication Date:
April 13, 2023
Filing Date:
August 31, 2022
Export Citation:
Assignee:
HOPE CITY (US)
International Classes:
A61K31/522; A61K31/7076; A61K31/713; A61K39/395; A61K47/54; A61P35/00
Domestic Patent References:
| WO2017205756A1 | 2017-11-30 |
Foreign References:
| US20100285041A1 | 2010-11-11 | |||
| US20030060440A1 | 2003-03-27 | |||
| US20170233739A1 | 2017-08-17 | |||
| US10758624B2 | 2020-09-01 | |||
| US20160355822A1 | 2016-12-08 |
Attorney, Agent or Firm:
GRIEFF, Edward D. (US)
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