Title:
OLIGONUCLEOTIDES FOR MODULATING RB1 EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2019/115417
Kind Code:
A3
Abstract:
The present invention relates to antisense oligonucleotides that are capable of modulating expression of RB1 in a target cell. The oligonucleotides hybridize to RB1 pre-mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment neurological injury or neuronal degeneration using the oligonucleotide.
Inventors:
HAGEDORN PETER (DK)
PEDERSEN LYKKE (DK)
PEDERSEN LYKKE (DK)
Application Number:
PCT/EP2018/084077
Publication Date:
August 22, 2019
Filing Date:
December 10, 2018
Export Citation:
Assignee:
ROCHE INNOVATION CT COPENHAGEN AS (DK)
International Classes:
C12N15/113; A61K31/7088
Domestic Patent References:
| WO2011005786A2 | 2011-01-13 | |||
| WO2011005793A1 | 2011-01-13 |
Foreign References:
| US20130150570A1 | 2013-06-13 | |||
| US20100273220A1 | 2010-10-28 | |||
| EP3159009A1 | 2017-04-26 |
Other References:
KIMBERLY J. CHRISTIE ET AL: "Enhancing adult nerve regeneration through the knockdown of retinoblastoma protein", NATURE COMMUNICATIONS, vol. 5, no. 1, 22 April 2014 (2014-04-22), XP055602857, DOI: 10.1038/ncomms4670
Attorney, Agent or Firm:
RUDOLPH HANSEN, Marianne (CH)
Download PDF: