Title:
OLIGOSACCHARIDE COMPOUND, MANUFACTURING METHOD THEREFOR, AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/141350
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an oligosaccharide with high versatility that can produce a protected sulfate oligosaccharide that can become a manufacturing intermediate of polysulfated hyaluronic acid, and to provide a manufacturing method therefor and an intermediate thereof. Position 2 amino groups in glucosamine, galactosamine, and the like can react with saccharide receptors having an electron attracting group such as glucuronic acid and protected sulfate groups, by using a saccharide donor protected by a specific protective group.
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Inventors:
GOTO FUMITAKA (JP)
TOMOYASU TAKAHIRO (JP)
OKAZAKI HIROKI (JP)
YUASA HIROAKI (JP)
OCHIAI HIROFUMI (JP)
AKAGI HIROSHI (JP)
SATO YUTA (JP)
SORAJO KOICHI (JP)
TOMOYASU TAKAHIRO (JP)
OKAZAKI HIROKI (JP)
YUASA HIROAKI (JP)
OCHIAI HIROFUMI (JP)
AKAGI HIROSHI (JP)
SATO YUTA (JP)
SORAJO KOICHI (JP)
Application Number:
PCT/JP2013/058252
Publication Date:
September 26, 2013
Filing Date:
March 22, 2013
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
OTSUKA CHEMICAL CO LTD (JP)
OTSUKA CHEMICAL CO LTD (JP)
International Classes:
C07H15/12; C07H19/04; C08B37/08
Domestic Patent References:
| WO1999052922A1 | 1999-10-21 | |||
| WO1991008748A1 | 1991-06-27 | |||
| WO2010087207A1 | 2010-08-05 |
Foreign References:
| JP2009526031A | 2009-07-16 | |||
| JPH05310770A | 1993-11-22 | |||
| JPH02300196A | 1990-12-12 | |||
| JPS6341493A | 1988-02-22 | |||
| JPS63218692A | 1988-09-12 | |||
| JPS63221104A | 1988-09-14 | |||
| JPS62138497A | 1987-06-22 | |||
| JPS62129295A | 1987-06-11 | |||
| JPS61243095A | 1986-10-29 | |||
| US5466681A | 1995-11-14 | |||
| US4871837A | 1989-10-03 | |||
| JP2012046511A | 2012-03-08 |
Other References:
JASPER DINKELAAR ET AL.: "Synthesis of Hyaluronic Acid Oligomers using Chemoselective and One-Pot Strategies", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 74, 2009, pages 4208 - 4216
KOEN M. HALKES ET AL.: "Synthesis of hyaluronic-acid-related oligosaccharides and analogues, as their 4-methoxyphenyl glycosides, having N-acetyl-beta-d-glucosamine at the reducing end", CARBOHYDRATE RESEARCH, vol. 309, 1998, pages 161 - 174
KOEN M. HALKES ET AL.: "Synthesis of hyaluronic-acid-related oligosaccharides and analogues, as their 4-methoxyphenyl glycosides, having N-acetyl-beta-d-glucosamine at the reducing end", CARBOHYDRATE RESEARCH, vol. 309, 1998, pages 161 - 174
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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