OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION

Title:

OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION

Document Type and Number:

WIPO Patent Application WO/2010/077678

Kind Code:

A3

Abstract:

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ω-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.

Inventors:

STAYTON PATRICK S (US)
HOFFMAN ALLAN S (US)
CONVERTINE ANTHONY J (US)
HENRY SCOTT M (US)
OVERELL ROBERT W (US)
JOHNSON PAUL H (US)

Application Number:

PCT/US2009/067193

Publication Date:

September 10, 2010

Filing Date:

December 08, 2009

Export Citation:

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Assignee:

UNIV WASHINGTON (US)
PHASERX INC (US)
STAYTON PATRICK S (US)
HOFFMAN ALLAN S (US)
CONVERTINE ANTHONY J (US)
HENRY SCOTT M (US)
OVERELL ROBERT W (US)
JOHNSON PAUL H (US)

International Classes:

C08F293/00; C08F2/38; C08F220/18; C08F222/06; C08F236/04

Domestic Patent References:

WO2005061555A1	2005-07-07
WO1998001478A1	1998-01-15

Foreign References:

US7081503B2	2006-07-25
US7009004B2	2006-03-07

Other References:

MICHAELA DANKOVA ET AL.: "Models for Conformationally Dynamic Metallocenes. Copolymerization Behavior of the Unbridged Metallocene (1-Methyl-2-phenylindenyl)(2-phenylindenyl)zirconium Dichloride", MACROMOLECULES, vol. 35, no. 8, 2002, pages 2882 - 2891, XP055124736
See also references of EP 2373715A4

Attorney, Agent or Firm:

RENZONI, George, E. (1420 Fifth Avenue Suite 280, Seattle WA, US)

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