ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES

Title:

ONCOLYTIC ADENOVIRUS ARMED WITH THERAPEUTIC GENES

Document Type and Number:

WIPO Patent Application WO/2005/107474

Kind Code:

A3

Abstract:

The present invention involves compositions and methods for treating preventing cancer using compositions including replication competent adenovirus. The application competent adenovirus may or may not encode a therapeutic polynucleotide.

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Inventors:

CHADA SUNIL (US)
WOLD WILLIAM (US)
ZUMSTEIN LOU (US)

Application Number:

PCT/US2005/015157

Publication Date:

April 09, 2009

Filing Date:

May 02, 2005

Export Citation:

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Assignee:

INTROGEN THERAPEUTICS INC (US)
UNIV SAINT LOUIS (US)
CHADA SUNIL (US)
WOLD WILLIAM (US)
ZUMSTEIN LOU (US)

International Classes:

A01N43/04; A01N63/00; A61K31/70; A61K35/76; A61K35/761; C07K14/47; C12N15/861

Foreign References:

US6627190B2	2003-09-30
US5747469A	1998-05-05
US6020191A	2000-02-01
US20040028654A1	2004-02-12

Other References:

RAMACHANDRA ET AL.: "Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy.", BIOTECHNOLOG/NATURE., vol. 19, November 2001 (2001-11-01), pages 1035 - 1041
PATAER ET AL.: "Adenoviral Transfer of the Malanoma Differentiation-associated Gene 7 (mda7) Induces Apoptosis of Lung Cancer Cells via Up-Retulation of the Double-Stranded RNA-dependent Protein Kinase (PKR).", CANCER RESEARCH., vol. 62, 15 April 2002 (2002-04-15), pages 2239 - 2243

Attorney, Agent or Firm:

LANDRUM, Charles, P. (600 Congress AvenueSuite 240, Austin TX, US)

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