Title:
ONCOLYTIC HETEROLOGOUS RECOMBINATION NEWCASTLE DISEASE VIRUS,PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/101326
Kind Code:
A1
Abstract:
Provided are an oncolytic heterologous recombination Newcastle disease virus (NDV),preparation method and application thereof. The heterologous recombination NDV can express an alpha (1, 3) galactosyltransferase (alpha (1, 3) GT); the alpha (1, 3) GT is the protein represented by the following B1) or B2): B1) the protein has an amino acid sequence of SEQ ID No.1; and B2) the protein is derived from B1) and has a function of the alpha (1, 3) GT obtained by substituting and/or deleting and/or adding one or more amino acid residue(s) in the amino acid sequence represented by SEQ ID No.1. The recombination NDV can be used for the tumor treatment.
Inventors:
PENG XIA (CN)
PENG YI (CN)
PENG YI (CN)
Application Number:
PCT/CN2015/000024
Publication Date:
June 30, 2016
Filing Date:
January 13, 2015
Export Citation:
Assignee:
ZHAO YONGXIANG (CN)
PENG XIA (CN)
PENG XIA (CN)
International Classes:
C12N7/01; A61K35/768; A61P35/00; C12N15/54; C12R1/93
Domestic Patent References:
| WO2014047350A1 | 2014-03-27 |
Foreign References:
| CN103352042A | 2013-10-16 | |||
| CN1704477A | 2005-12-07 | |||
| CN103343141A | 2013-10-09 | |||
| US20130202558A1 | 2013-08-08 |
Other References:
DATABASE GenPept [O] 26 January 2014 (2014-01-26), MCGREGOR, C.G. ET AL.: "N-acetyllactosaminide alpha-1,3-galactosyltransferase [Sus scrofa]", Database accession no. NP_998975.1
BEIER, R. ET AL.: "Isolation of More Potent Oncolytic Paramyxovirus by Bioselection", GENE THERAPY, vol. 20, no. 1, 31 January 2013 (2013-01-31), pages 102 - 111, ISSN: 0929-1903
ZHU, YANMEI ET AL.: "Construction and Rescue of Infectious cDNA Clone of Pigeon-origin Newcastle Disease Virus Strain JS/07/04/Pi", CHINESE JOURNAL OF VIROLOGY, vol. 28, no. 1, 31 January 2012 (2012-01-31), pages 67 - 72, ISSN: 1000-8721
BEIER, R. ET AL.: "Isolation of More Potent Oncolytic Paramyxovirus by Bioselection", GENE THERAPY, vol. 20, no. 1, 31 January 2013 (2013-01-31), pages 102 - 111, ISSN: 0929-1903
ZHU, YANMEI ET AL.: "Construction and Rescue of Infectious cDNA Clone of Pigeon-origin Newcastle Disease Virus Strain JS/07/04/Pi", CHINESE JOURNAL OF VIROLOGY, vol. 28, no. 1, 31 January 2012 (2012-01-31), pages 67 - 72, ISSN: 1000-8721
Attorney, Agent or Firm:
JEEKAI & PARTNERS (CN)
北京纪凯知识产权代理有限公司 (CN)
北京纪凯知识产权代理有限公司 (CN)
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