CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims benefit under 35 U.S.C. § 119(e) of U.S. Provisional

Application No. 62/156,447, filed May 04, 2015, the contents of which are incorporated herein by reference in their entirety.

SEQUENCE LISTING

[0002] The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on April 21 , 2016, is named 043214-084831 -PCT_SL.txt and is 221,995 bytes in size.

FIELD OF INVENTION

[0003] The present invention is directed compositions and methods of treating cancer of the brain in a patient using oncolytic herpes simplex virus 1 (HSV-1).

BACKGROUND

[0004] Many malignant tumors are intrinsically resistant to conventional therapies and represent significant therapeutic challenges, e.g. malignant gliomas and recurrent systemic solid tumors such as lung cancer. Malignant gliomas are the most abundant primary brain tumors, having an annual incidence of 6.4 cases per 100,000. These neurological ly devastating tumors are the most common subtype of primary brain tumors and are one of the deadliest human cancers. In the most aggressive cancer manifestation, glioblastoma multiforme (GBM), median survival duration for patients is 14 months, despite maximum treatment efforts. Treatments for the most malignant types of brain tumors (malignant glioma /glioblastoma multiforme, GBM) fail to provide long-lasting control with 50% of afflicted patients dying within 15 months from diagnosis, in spite of a variety of treatments such as surgery, radiation and chemotherapy. A variety of experimental treatments have been tried and tested. Because few good treatment options are available for many of these refractory tumors, the exploration of novel and innovative therapeutic approaches is important. [0005] One area of experimental therapy has involved the use of oncolytic (tumor- killing) viruses, whose infection and replication into tumor cells has been engineered to be tumor- selective. Replication selective oncolytic viruses have shown great promise as anti-tumor agents for solid tumors. The viruses have been constructed genetically so that they are able to preferentially replicate within tumor cells, while being at least somewhat restricted in their ability to replicate in normal cells. The principal anti-tumor mechanism of oncolytic viruses is through a direct cytopathic effect as they propagate and spread from initially infected tumor cells to surrounding tumor cells, achieving a larger volume of distribution and anticancer effects.

[0006] Oncolytic herpes simplex viruses (HSVs) were initially designed and constructed for the treatment of brain tumors. Subsequently, they have been found to be effective in a variety of other human solid tumors, including breast, prostate, lung, ovarian, colon and liver cancers. The safety of oncolytic HSVs has also been extensively tested in mice and primates, which are extremely sensitive to HSV. One oncolytic HSV-1 mutant that has been studied as a glioma-specific therapeutic is rQNestin.34.5 (Kambara et al. An oncolytic HSV-1 mutant expression ICP34.5 under control of a Nestin promoter increases survival of animals even when symptomatic from a brain tumor, (2005) Cancer Res, 65(7): 2832-2839).

[0007] Despite encouraging preclinical studies, results from early clinical trials have suggested that most of the current versions of oncolytic viruses, although acceptably safe, may only have limited anti-tumor activity on their own.

[0008] Considering the limited effective treatment options available for certain types of cancer, including certain types of brain cancer, there remains a need in the art for improved oncolytic viruses.

SUMMARY OF THE INVENTION

[0009] We have generated an improved oncolytic rQNestin34.5 HSV virus, a second generation vims referred to as rQNestin34.5.v2. The genetically modified HSVl

rQNestin34.5.v2 has been made glioma- selective by the following maneuvers: 1 ) one of the viral genes that encodes for a viral protein (ICP6) has been removed. Without this gene, HSVl has to utilize factors within the infected cells to efficiently grow and replicate and we have shown that such factors are existent in cells that are mitotically active or that have a defect in a cellular gene (pi 6) that is missing in most gliomas; and 2) the two copies of the viral gene that encode for a protein (ICP34.5) needed for robust viral growth in an infected cell have also been removed and one copy was reinserted under control of a Nestin promoter that is also present selectively in gliomas in the adult human brain. These two maneuvers combined with the reduced toxicity due to lack of ICP6-EGFP fusion protein present in the first generation rQNestin34.5 (Kambara et al. An oncolytic HSV-1 mutant expression ICP34.5 under control of a Nestin promoter increases survival of animals even when symptomatic from a brain tumor, (2005) Cancer Res. 65(7): 2832-2839), allow this new HSV1 (designated as rQNestin34.5v.2) to be relatively selective in destroying gliomas and not normal brain cells. We have confirmed this in cultured cells and in animal models.

[0010] Accordingly, provided herein are tumor-selective oncolytic herpes viral vectors comprising: a) a deletion or inactivating mutation in both copies of the gene encoding γ34.5; b) an insertion of at least one copy of the HSV γ34.5 gene under the transcriptional control of a nestin promoter; and c) a deletion or inactivating mutation in the gene that encodes for the HSV viral protein ICP6, wherein the tumor-selective oncolytic herpes viral vector does not express green fluorescent protein. In one embodiment, the vector does not express ICP6-EGFP fusion protein present in the first generation HSV-1 vector rQNestin34,5. In one embodiment the turn or- selective oncolytic herpes viral vector does not comprise SEQ ID NO: 7. In one embodiment, the vector does not contain UL39 nucleic acid regulator ' sequences (promoter and enhancer elements). In one embodiment, the vector does not contain a fusion protein of ICP6. In one embodiment, the at least one copy of the γ34.5 gene under the transcriptional control of a nestin promoter is inserted into UL39 gene that encodes for the large sub unit of ribonucleotide reductase ICP6 (infected cell protein 6). In one embodiment, the nestin promoter comprises SEQ ID NO: 2 or a degenerate variant thereof. In one embodiment the tumor-selective oncolytic herpes viral vector comprises SEQ ID NO: 8.

[0011] Also provided is a tumor- selective oncolytic herpes viral vector that comprises the sequence of SEQ ID NO: 1, or a degenerate variant thereof.

[0012] Another aspect of the invention provides for a method of selectively killing intracranial tumor cells in a subject, comprising introducing into the vicinity of the tumor- selective oncolytic herpes viral vectors of the invention. We have determined that one additional maneuver allows rQNestin34.5v.2 to be highly effective in injected gliomas. Mammals are able to rapidly counteract FISVl in the brain through their initial immune responses. Brain cells such as microglia and systemic cells such as NK cells and macrophages can blunt and effectively ensure that viral replication and its untoward consequences on normal brain does not occur. We have discovered that such innate initial host defenses also exist in the context of gliomas injected with rQNestin34.5v,2 that curtail the biodistribution of the virus within the tumor and limit its therapeutic effectiveness. In animal models, we have discovered that a single dose of

cyclophosphamide, a commonly utilized agent that modulates the immune response,

administered two days before rQNestin34.5v.2 significantly enhances viral biodistribution, replication and efficacy, effectively reducing the dose of virus required to produce a survival effect by two orders of magnitude.

[0013] Accordingly, in one embodiment, the method further comprises administration of cyclophoshamide (CPA). In certain embodiments, the CPA is administered, simultaneously with the HSV oncolytic vector. In certain embodiments the CPA is administered hours, days, or weeks before the administration of the HSV-1 oncolytic vector. In one embodiment, the CPA is administered two days before the oncolytic herpes viral vector.

[0014] In some embodiments, the tumor ceils comprise a glioblastoma cell, or a cancer stem cell. In some embodiments, the subject to be treated is a mammal. In certain embodiments, the mammal is human.

[0015] Also provided are pharmaceutical compositions of the tumor-selective oncolytic herpes viral vectors of the invention described herein for use in the treatment of intracranial tumor ceils in a subject. In various embodiments, tumor-selective oncolytic herpes viral vectors comprising: a) a deletion or inactivating mutation in both copies of the gene encoding g34.5; b) an insertion of at least one copy of the HSV γ34.5 gene under the transcriptional control of a Nestin promoter; and c) a deletion or inactivating mutation in the gene that encodes for the HSV viral protein ICP6, wherein the tumor-selective oncolytic herpes viral vector does not express green fluorescent protein. In one embodiment, the vector does not express ICP6-EGFP fusion protein present in the first generation HSV-1 vector rQNestin34.5. In one embodiment the tumor- selective oncolytic herpes viral vector does not comprise SEQ ID NO: 7. In one embodiment, the vector does not contain UL39 nucleic acid regulatory sequences (promoter and enhancer elements). In one embodiment, the vector does not contain a fusion protein of ICP6. In one embodiment, the at least one copy of the v34.5 gene under the transcriptional control of a nestin promoter is inserted into UL39 gene that encodes for the large subunit of ribonucleotide reductase ICP6 (infected cell protein 6). In one embodiment, the nestin promoter comprises SEQ ID NO: 2 or a degenerate variant thereof. In one embodiment the tumor-selective oncolytic herpes viral vector comprises SEQ ID NO: 8.

BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Exemplary embodiments are illustrated in the referenced figures. It is intended that the embodiments and figures disclosed herein are to be considered illustrative rather than restrictive.

[0017] Figure 1 is a schematic of rQNestin34v.2. Schematic maps of HSV strain F (wild- type), rHsvQl (double UL39-y34.5 mutant), and rQNestin34.5. All strains contain the typical HSV-1 genome with its two unique segments (UL and US, respectively), each flanked by inverted repeat elements (ab and ca, respectively). The locations of diploid γ34.5 genes and of the thymidine kinase gene (tk ) are shown in the top construct, representing wild-type F strain HSV. In the middle construct, UL39 (ICP6) has been deleted of its coding sequences and the deletions within yl 34.5 are shown for rHsvQl . These consist of a deletion of about 1,000 bp in the coding region. The bottom construct shows the site of recombination of the hybrid promoter (nestin enhancer and hsp68 minimum promoter)-yl 34.5 expression cassette into the ICP6 loss, giving rise to the novel mutant oncolytic virus rQNestin34.5v.2. The approximate sizes of the Hindlll fragment from rQNestin34.5 are provided (from Kambara et al., Cancer Res., 20051). rQNestin34.5v.2 was sequenced in its entirety to confirm its identity (SEQ ID NO: 1).

[0018] Figure 2 are western blots of several glioma cells (U87dEGFR, U251, U138 and

Gli36dEGFR) and freshly explanted glioma "stem-like" cells (GBM 02) and normal human astrocytes (HA) andendothelial cells (HUVEC) were infected with rQNestin 34.5 v.2 or parental rQNestin34.5 (v.1), control rQl virus, wild-type F strain or uninfected (cell). Lysates were then harvested and Western blots carried out to visualize total eiF2a and phospho-eiF2a (eiF2a- Pser51). X12 (another GSC) is not included but showed same results as OG02.

[0019] Figure 3 is a schematic of the construction of the fHSVQ2-X series of bacterial artificial chromosomes (BAC) that contain the entire HSV1 genome with endogenous HSV1 ICP34.5 and ICP6 deletions and insertion of a large sequence utilized for transfer of exogenous sequences, such as the Nestin/hsp68 promoter/enhancer sequence (marked by X).

[0020] Figure 4 is a schematic of the engineering of rQNestin34.5 v.2 (rQNestin34.5 lacking ICP6GFP). A bacterial artificial chromosome (BAC) containing the HSV1 genome lacking both copies of the HSV1 gene γ134.5, encoding for the viral protein ICP34.5 and with a large deletion of the viral gene for ICP6 (only some 3' sequence remains) was obtained

(designated as fHSVQuick-2). A plasmid with the Nestin-promoter enhancer element upstream of a γΐ 34.5 transgene (pT-Nestin34.5) is then recombined by site-specific recombination into the FRT locus by employing FLP. The BAC concatenate (fHSVQ2-Nestin34.5 v.2) is then purified from bacteria and electroporated in mammalian Vero cells in the presence of Cre recombinase to remove internal antibiotic resistance sites, fluorescent proteins sites, such as DSRedl, FRT site and F plasmid origin of replication. The viral genome will replicate in Vero cells, generating rQNestin34.5 v.2 virions, (see for example Terada et al. Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using synergenic mouse tumor models. Gene Ther. 13 : 705-714, 2006).

[0021] Figure 5 is a graph depicting viral yields in human glioma cells and normal human astrocytes. Normal human astrocytes (HA) and human glioma cells, U87dEGFR

(U87dE) and U251, were cultured in the presence of rQNestin34.5v.2 (v2), parental rHSVQl (Ql), wild-type F strain (F), and also another oncolytic viral construct unrelated to this project (34C). Viral yields were then assayed 3 days later.

[0022] Figure 6 is a graph depicting cell survival in various cells. rQNestin34.5v.2 was added to a panel of glioma cells, U87dEGFR (U87dEGFR), U87, U251 and OG02 and to a panel of normal cells, human astrocytes (HA), human fibroblasts (Fibro.), human smooth muscle (SM), human skeletal muscle cells (SkM) and mouse astrocytes (MA). Surviving cells were then counted 5 days later by Coulter counter enumeration

[0023] Figures 7A is a graph showing mouse survival (y) over time (x). U87dEGFR glioma cells (2 x 10 ⁵ ) were implanted in the brain of 8 week old athymic mice. One week later, PBS, rHSVQl, rQNestin34.5v. l and rQNestin34.5v.2 (3 x 10 ⁵ pfu in 5 ul) were injected into the same location. Survival was then monitored. [0024] Figure 7B is a graph showing mouse survival rate (y) over time (x). U87dEGFR glioma cells (2 x 10 ⁵ ) were implanted in the brain of 8 week old athymic mice. Two weeks later, PBS, rHSVQl, rQNestin34.5v. l and rQNestin34.5v.2 (3 x 10 ⁵ pfu in 5 ul) were injected into the same location. Survival was then monitored.

[0025] Figure 8 is a table that summarizes the results of all experiments to date with

Balb/c mice. Intracerebral injection of 107 pfus in either 8 week old or 6 month old mice was well tolerated (32/33, with one death at day 3 post-injection for unknown reasons)

[0026] Figure 9 is a graph showing replication of rQNestin34.5v.2 (v2) which was analyzed in 5 glioma stem cells (brain tumor initiating cells - BTIC) freshly generated from humans (G35, G68, G97, OG02, X12). HSVQ1 (Ql) an ICP34.5 deleted virus showed no or minimal replication. F (wild-type HSV) showed the most replication. 34C is an unrelated HSV recombinant HSV.

[0027] Figure 10 shows RT-PCR for LAT transcript in mice treated with

rQNestin34.5v.2 or F. The former was injected ic, i.t. or i.v,. at a dose of 10 ⁷ pfus. 60 days later, RT-PCR in 6 different brains and 6 different trigeminal ganglia was performed for the LAT transcript (35 cycles). The positive control for the reaction consisted of glioma cells infected with rQNestin34.5v.2. F strain virus was injected i.e. and mice were sacrificed 30 or 60 days later to detect LAT.

[0028] Figure 11 shows PCR for DNA pol transcript in mice treated with

rQNestin34.5v.2 or F. The former was injected ic, i.t. or i.v,. at a dose of 10 ⁷ pfus. 60 days later, PCR in different brains and 5 different trigeminal ganglia was performed for the LAT transcript (35 cycles). The positive control for the reaction consisted of glioma cells infected with rQNestin34.5v.2. F strain virus was injected i.e. and mice were sacrificed 30 or 60 days later to detect DNA pol.

[0029] Figures 12A to 12B show a schematic and graph. Figure 12A schematic of the toxicity studies in mice. Figure 12B a graph showing survival rate vs time after injection of rQNestin34.5v.2 (v2-lxl0 ⁷ ) and wild type HSV1 F strain.

[0030] Figures 13 A and 13B show a schematic and graph. Figure 13 A schematic of the preclinical studies in mice using CPA. Figure 13B a graph showing survival rate vs time after injection of rQNestin34.5v.2 (v2-lxl07) and wild type HSV1 F strain. CPA (300 mg/kg) was administered i.p., two days before intracranial inoculation of rQNestin34.5v2 (v2) at 10 ⁶ pfus (blue triangle with broken line), 3 x 10 ⁶ pfus (light blue circle/line), or 10 ⁷ pfus (blue

diamond/line). The numerator represents animal euthanized (due to veterinary criteria of toxicity) or found dead, while the denominator represents total number injected. F represents wild-type HSVl F strain, injected at 10 ³ pfus (red cross/line). PBS represents intracranial vehicle injection. The experiment was terminated at day 62-63 with planned euthanasia of all surviving animals to harvest organs for toxicity /biodistribution analyses.

[0031] Figure 14 shows a graph of the relative body weight over time after injection of the mice used in Figure 13.

[0032] Figure 15 shows a schematic of the deleted region in fHSVQuick-1 by homologous recombination with PCR fragment (del-GFP-FRT-Gm-F&R).

[0033] Figure 16 shows a schematic of the PCR Fragment del-GFP-FRT-Gm-F&R used for homologous recombination.

[0034] Figures 17A to 17D show Nestin expression in human brain adjacent to gliomas.

The subject is a 50+ year old male with a MG. As part of the resection, brain adjacent to tumor and devoid of gross tumor was also resected up to the ventricle. Figure 17A shows GFAP immunohistochemistry with several positive astrocytes in the high power microphotograph. Figure 17B shows that Nestin immunohistochemistry of a similar area is relatively negative. Figure 17C shows Nestin immunohistochemistry (IHC) of the subventricular zone (SVZ) (Arrows) was also negative (low power). Figure 17D shows high power microphotograph of Nestin IHC of SVZ (arrows).

[0035] Figures 18A to 18C show Nestin expression in human brain after treatment. The subject was a 50+ year old male with a history of MG, who underwent surgery, radiation and chemotherapy. The patient passed away of causes other than tumor. At postmortem, there was no tumor in brain. Nestin IHC again showed little if any evidence of positivity within the white matter where the subject was treated for his tumor. Figure 18 A- Low power; Figure 18B- Mid- power; Figure 18C- High power microphotograph.

[0036] Figures 19A to 19C show nestin expression in the brains of athymic mice. The brain of this athymic mouse was inoculated with vehicle (PBS). At day 4, the mouse was euthanized and brain was harvested. Nestin IHC was performed. Positive nestin IHC is visualized in tanicytes (i.e. cells in ependymal layer of lateral ventricle (upper left panel, Figure 19 A) of third ventricle (upper right panel, Figure 19B) and aqueduct (lower left panel, Figure 19C). Each panel shows a low power microphotograph of the entire brain, with the boxed inset showing the high power one.

[0037] Figure 20 shows bioequivalency of viral yields of rQNestin34.5v.2 and rQNestin in HUVEC cells and established U251, U87dEGFR glioma cells and OG02 glioma "stem-like" cells. The plot shows that the viral yield of rQnestin34.5v.2 was equivalent to that of rQNestin34.5 in 3 glioma cells, including a glioma stem-like cell and superior to that in HUVEC cells.

[0038] Figure 21 shows plot of replication assay results comparing yields of

rQNestin34.5v.2, control rHSVQl and wild-type F strain in 4 established glioma cell lines (U251, GH36, T98G, and U87dE) , 3 glioma stem-like cells (G97, OG02, X12) and 4 normal cells (HUVEC, Skeletal muscle-SKM, Smooth musckle-SM, and Fibroblasts). The plot shows that shows that rQNestin34.5v.2 replication was higher than that of the ICP34.5 -negative rHSVQl in 4 established glioma cell lines and 3 primary gliomas grown under stem-like condition, but similar to rHSVQl in 4 normal cells. F strain replication was higher in all.

[0039] Figures 22A to 22D show cytotoxicity of rQNestin34.5 and QNestin34.5V.2 rQNestin34.5v.2 was equivalent to rQNestin34.5 in cytotoxicity at all tested MOIs against a panel of normal and glioma cells. Figure 22A HUVEC; Figure 22B U251; Figure 22C

U87AEGFR; Figure 22D Gli36AEGFR.

DESCRIPTION OF THE INVENTION

[0040] All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless otherwise defined herein, scientific and technical terms used in connection with the present application shall have the meanings that are commonly understood by those of ordinary skill in the art to which this disclosure belongs. It should be understood that this invention is not limited to the particular methodology, protocols, and reagents, etc., described herein and as such can vary. Definitions of common terms can be found in Singleton et al., Dictionary of Microbiology and Molecular Biology 3 ^rd ed., J. Wiley & Sons New York, NY (2001); March, Advanced Organic Chemistry Reactions, Mechanisms and Structure 5 ^th ed., J. Wiley & Sons New York, NY (2001); Michael Richard Green and Joseph Sambrook, Molecular Cloning: A Laboratory Manual, 4th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., USA (2012); Davis et al., Basic Methods in Molecular Biology, Elsevier Science Publishing, Inc., New York, USA (2012); Jon Lorsch (ed.) Laboratory Methods in Enzymology: DNA, Elsevier, (2013); Frederick M. Ausubel (ed.), Current Protocols in

Molecular Biology (CPMB), John Wiley and Sons, (2014); John E. Coligan (ed.), Current Protocols in Protein Science (CPPS), John Wiley and Sons, Inc., (2005); and Ethan M Shevach, Warren Strobe, (eds.) Current Protocols in Immunology (CPI) (John E. Coligan, ADA M

Kruisbeek, David H Margulies, John Wiley and Sons, Inc., (2003); each of which provide one skilled in the art with a general guide to many of the terms used in the present application.

[0041] One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. Indeed, the present invention is in no way limited to the methods and materials described. For purposes of the present invention, certain terms are defined below.

[0042] In some embodiments, the numbers expressing quantities of ingredients, properties such as molecular weight, reaction conditions, and so forth, used to describe and claim certain embodiments of the application are to be understood as being modified in some instances by the term "about." Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the application are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.

[0043] The term "mammal," as used herein, refers to a member of the class Mammalia, including, without limitation, humans, as well as nonhuman primates such as chimpanzees and other apes and monkey species; farm animals such as cattle, sheep, pigs, goats and horses;

domestic mammals such as dogs and cats; laboratory animals including rodents such as mice, rats and guinea pigs, and the like. [0044] The term "vector," as used herein, refers to a carrier nucleic acid molecule into which a nucleic acid sequence can be inserted for introduction into a cell where it can be replicated. A nucleic acid sequence can be "exogenous," which means that it is foreign to the cell into which the vector is being introduced or that the sequence is homologous to a sequence in the cell but in a position within the host cell nucleic acid in which the sequence is ordinarily not found. Vectors include plasmids, cosmids, viruses (bacteriophage, animal viruses, and plant viruses), and artificial chromosomes (e.g., YACs). One of skill in the art would be well equipped to construct a vector through standard recombinant techniques (see, for example, Maniatis et al., 1988 and Ausubel et al., 1994, both of which are incorporated herein by reference). Additionally, the techniques described herein and demonstrated in the referenced figures are also instructive with regard to effective vector construction.

[0045] The term "oncolytic HSV-1 vector" refers to a genetically engineered HSV-1 virus corresponding to at least a portion of the genome of HSV-1 that is capable of transducing a target cell, replicating, and being packaged into HSV-1 virions. The genetically engineered virus comprises deletions and or mutations and or insertions of nucleic acid that render the virus oncolytic such that the engineered virus replicates in- and kills- tumor cells by oncolytic activity. The virus may be attenuated or non-attenuated. The virus may or may not deliver a transgene- that differs from the HSV viral genome. In one embodiment, tbe oncolytic HSV-1 vector does not express a transgene to produce a protein foreign to the virus.

[0046] HSV-1 is a human neurotropic virus that is capable of infecting virtually all vertebrate cells. Natural infections follow either a lytic, replicative cycle or establish latency, usually in peripheral ganglia, where the DNA is maintained indefinitely in an episomal state. HSV-1 contains a double-stranded, linear DNA genome, 153 kilobases in length, which has been completely sequenced by McGeoch (McGeoch et al., J. Gen. Virol. 69: 1531 (1988); McGeoch et al., Nucleic Acids Res 14: 1727 (1986); McGeoch et al., J. Mol. Biol. 181 : 1 (1985); Perry and McGeoch, J. Gen. Virol. 69:2831 (1988)). DNA replication and virion assembly occurs in the nucleus of infected cells. Late in infection, concatemeric viral DNA is cleaved into genome length molecules which are packaged into virions. In the CNS, herpes simplex virus spreads transneuronally followed by intraaxonal transport to the nucleus, either retrograde or

anterograde, where replication occurs. [0047] The term "expression vector" refers to any type of genetic construct comprising a nucleic acid coding for a RNA capable of being transcribed. In some cases, RNA molecules are then translated into a protein, polypeptide, or peptide. In other cases, these sequences are not translated, for example, in the production of antisense molecules or ribozymes. Expression vectors can contain a variety of "control sequences," which refer to nucleic acid sequences necessary for the transcription and possibly translation of an operably linked coding sequence in a particular host cell. In addition to control sequences that govern transcription and translation, vectors and expression vectors may contain nucleic acid sequences that serve other functions as well and are described infra.

[0048] The term "promoter," as used herein, refers to a nucleic acid sequence that regulates, either directly or indirectly, the transcription of a corresponding nucleic acid coding sequence to which it is operably linked. The promoter may function alone to regulate transcription, or, in some cases, may act in concert with one or more other regulatory sequences such as an enhancer or silencer to regulate transcription of the gene of interest. The promoter comprises a DNA regulatory sequence, wherein the regulatory sequence is derived from a gene, which is capable of binding RNA polymerase and initiating transcription of a downstream (3'- direction) coding sequence. A promoter generally comprises a sequence that functions to position the start site for RNA synthesis. The best-known example of this is the TATA box, but in some promoters lacking a TATA box, such as, for example, the promoter for the mammalian terminal deoxynucleotidyl transferase gene and the promoter for the SV40 late genes, a discrete element overlying the start site itself helps to fix the place of initiation. Additional promoter elements regulate the frequency of transcriptional initiation. Typically, these are located in the region 30-110 bp upstream of the start site, although a number of promoters have been shown to contain functional elements downstream of the start site as well. To bring a coding sequence "under the control of a promoter, one can position the 5' end of the transcription initiation site of the transcriptional reading frame "downstream" of (i.e., 3' of) the chosen promoter. The "upstream" promoter stimulates transcription of the DNA and promotes expression of the encoded RNA.

[0049] The spacing between promoter elements frequently is flexible, so that promoter function is preserved when elements are inverted or moved relative to one another. Depending on the promoter used, individual elements can function either cooperatively or independently to activate transcription. The promoters described herein may or may not be used in conjunction with an "enhancer," which refers to a cis-acting regulatory sequence involved in the

transcriptional activation of a nucleic acid sequence, such as those for the genes, or portions or functional equivalents thereof, listed herein.

[0050] A promoter may be one naturally associated with a nucleic acid sequence, as may be obtained by isolating the 5' non-coding sequences located upstream of the coding segment and/or exon. Such a promoter can be referred to as "endogenous." Similarly, an enhancer may be one naturally associated with a nucleic acid sequence, located either downstream or upstream of that sequence. Alternatively, certain advantages may be gained by positioning the coding nucleic acid segment under the control of a recombinant or heterologous promoter, which refers to a promoter that is not normally associated with a nucleic acid sequence in its natural environment. A recombinant or heterologous enhancer refers also to an enhancer not normally associated with a nucleic acid sequence in its natural environment. Such promoters or enhancers may include promoters or enhancers of other genes, and promoters or enhancers isolated from any other virus, or prokaryotic or eukaryotic cell, and promoters or enhancers not "naturally occurring," i.e., containing different elements of different transcriptional regulatory regions, and/or mutations that alter expression. For example, promoters that are most commonly used in recombinant DNA construction include the beta-lactamase (penicillinase), lactose and tryptophan (trp) promoter systems. As demonstrated herein, in some embodiments, a nestin promoter is used to drive expression of the gene of interest. In addition to producing nucleic acid sequences of promoters and enhancers synthetically, sequences may be produced using recombinant cloning and/or nucleic acid amplification technology, in connection with the compositions disclosed herein (see U.S. Pat. Nos. 4,683,202 and 5,928,906, each incorporated herein by reference). Furthermore, it is contemplated the control sequences that direct transcription and/or expression of sequences within non-nuclear organelles such as

mitochondria, chloroplasts, and the like, can be employed as well.

[0051] A "gene," or a "sequence which encodes" a particular protein, is a nucleic acid molecule which is transcribed (in the case of DNA) and translated (in the case of mRNA) into a polypeptide in vitro or in vivo when placed under the control of one or more appropriate regulatory sequences. A gene of interest can include, but is no way limited to, cDNA from eukaryotic mRNA, genomic DNA sequences from eukaiyotic DNA, and even synthetic DNA sequences. A transcription termination sequence will usually be located 3' to the gene sequence. Typically, a polvadenvlation signal is provided to terminate transcription of genes inserted into a recombinant virus.

[0052] The term "polypeptide" or "protein," as used herein, means a polymer of amino acids joined in a specific sequence by peptide bonds. As used herein, the term "amino acid" refers to either the D or L stereoisomer form of the amino acid, unless otherwise specifically designated.

[0053] The term "transgene" refers to a particular nucleic acid sequence encoding a polypeptide or a portion of a polypeptide to be expressed in a cell into which the nucleic acid sequence is inserted. The term "transgene" is meant to include (1) a nucleic acid sequence that is not naturally found in the cell {i.e., a heterologous nucleic acid sequence); (2) a nucleic acid sequence that is a mutant form of a nucleic acid sequence naturally found in the cell into which it has been inserted; (3) a nucleic acid sequence that serves to add additional copies of the same {i.e., homologous) or a similar nucleic acid sequence naturally occurring in the ceil into which it has been inserted; or (4) a silent naturally occurring or homologous nucleic acid sequence whose expression is induced in the cell into which it has been inserted. A "mutant form" or "modified nucleic acid" or "modified nucleotide" sequence means a sequence that contains one or more nucleotides that are different from the wild-type or naturally occurring sequence, i.e., the mutant nucleic acid sequence contains one or more nucleotide substitutions, deletions, and/or insertions. In some cases, the gene of interest may also include a sequence encoding a leader peptide or signal sequence such that the transgene product may be secreted from the ceil .

[0054] As used herein, the term "transfection" refers to the uptake of foreign DNA by a mammalian cell. A cell has been "transfected" when exogenous DNA has been introduced inside the cell membrane. A number of transfection techniques are known in the art. See, Michael Richard Green and Joseph Sambrook, Molecular Cloning: A Laboratory Manual, 4th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., USA (2012); Davis et al., Basic Methods in Molecular Biology, Elsevier Science Publishing, Inc., New York, USA (2012); Jon Lorsch (ed.) Laboratory Methods in Enzymology: DNA, Elsevier, (2013); Frederick M. Ausubel (ed.), Current Protocols in Molecular Biology (CPMB), John Wiley and Sons, (2014). Such techniques can be used to introduce one or more exogenous DNA moieties, such as a viral vector and other nucleic acid molecules, into suitable host cells. The term refers to both stable and transient uptake of the genetic material.

[0055] The term "oncolytic activity," as used herein, refers to cytotoxic effects in vitro and/or in vivo exerted on tumor cells without any appreciable or significant deleterious effects to normal cells under the same conditions. The cytotoxic effects under in vitro conditions are detected by various means as known in prior art, for example, by staining with a selective stain for dead cells, by inhibition of DNA synthesis, or by apoptosis. Detection of the cytotoxic effects under in vivo conditions is performed by methods known in the art.

[0056] A "biologically active" portion of a molecule, as used herein, refers to a portion of a larger molecule that can perform a similar function as the larger molecule. Merely by way of non-limiting example, a biologically active portion of a promoter is any portion of a promoter that retains the ability to influence gene expression, even if only slightly. Similarly, a biologically active portion of a protein is any portion of a protein which retains the ability to perform one or more biological functions of the full-length protein (e.g. binding with another molecule, phosphorylation, etc.), even if only slightly.

[0057] With the aforementioned preliminary descriptions and definitions in mind, additional background is provided herein below to provide context for the genesis and development of the inventive vectors, compositions and methods described herein.

[0058] Current mutant HSV-1 vectors that target malignant glioma are based on the two deletion mutant genes, ICP6 (UL39 gene product), the large subunit of HSV-1 ribonucleotide reductase (RR), and ICP34.5 (34.5 gene product), a multifunctional protein that is also related to neurovirulence. While the lack of ICP6 restricts virus replication to non-dividing cells but allows replication to continue in cells with defects in the pi 6 tumor suppressor pathway, deletions of both γ ₂ 34.5 genes suppresses HSV-1 encephalitis. This may be due to ICP34.5's facilitation of Beclin-1 autophagy function, essential for neurovirulence. Besides this autophagic inhibitory effect, ICP34.5 also counteracts a host defense mechanism triggered by viral infection. This mechanism activates PKR (double-stranded RNA protein kinase) that then phosphorylates the translation factor, eIF2a, leading to translation inhibition. ICP34.5 directly binds and activates PP1 (protein phosphatase 1) that dephosphorylates eIF2a, allowing for viral mRNA translation to continue. Oncolytic HSV-1 with mutated γ34.5 genes (e.g. G207, 1716) has proven to be safe for administration in humans with gliomas in multiple clinical trials, but efficacy has been elusive, probably due to their limited viral replication. To overcome this limitation, an HSV1 was previously engineered, wherein the ICP34.5 gene is under the transcriptional control of the glioma stem cell promoter for nestin. rQNestin34.5 has exhibited increased efficacy in glioma models.

[0059] Nestin is an intermediate filament predominantly expressed in neural stems cells during embryogenesis, and is considered to be upregulated in glioma. A variety of primary tumors of the central nervous system (CNS) display elevated levels of nestin within tumor and/or endothelial cells. This transcriptionally driven oncolytic virus has shown efficient anti-tumor efficacy against CNS and neuroblastoma tumors in vitro and in vivo. Nestin gene sequence can be found in Genebank Gene ID: 10763, Chromosome 1 - NC_000001.11 (156668763..156677397, complement).

[0060] The Herpes Gamma (γ) 34.5 Gene

[0061] Published results have demonstrated that at least one function of the herpes γ34.5 gene (which is alternatively known as the γ 34.5 gene) is to preclude the host cell's response to viral infection, namely the triggering of host protein synthesis shutoff in an apoptotic-like response (Chou, J., et al., Science 250: 1262-1266 (1990); Chou, J. and Roizman, B., Proc. Natl Acad. Sci. USA 89:3266-3270 (1992); Chou, .) ^" ., et al., Proc. Nad. Acad Sci. USA 92: 10516- 10520 (1995)). A similar function is widespread among pathogenic viruses (Cosentino, G. P., et al, Proc. Natl Acad. Sci. USA 92:9445-9449 (1995); Gale, M., Jr., et al., . Mol. Cell Biol.

18:5208-5218 (1998); Katze, M. G, et al ., Trends Microbiol 3 :75-78 (1995); Sharp, T. V., et al., Nuc. Acids lies. 27:4483-4490 (1993)),

[0062] While γ34.5 is nonessential for viral growth in culture in Vero cells, it enables the virus to spread in the central nervous system (CNS) of mice, and maps to a region of the HSV genome previously implicated in CNS replication (Markovitz, N. S., et al, J. Virol. 71 :5560- 5569 (1997); Centifanto-Fitzgerald, Y. M., et al, J. Esp. Pled 155:475-489 (1982)). This may be due to the fact that the y34.5-encoded protein inhibits the double-stranded RNA-dependent kinase (PKR). On exposure to double stranded RNA molecules, as seen commonly with viral infection, PKR phosphorylates the alpha subunit of elongation initiation factor eIF-2, resulting in inhibition of protein synthesis (Chou, J., et al, Science 250: 1262-1266 (1990); Chou, J. and Roizman, B., Proc. Natl Acad. Sci USA 89:3266-3270 (1992); Chou, .) ., et al., J. Virol 68:8304- 8311 (1994)). Infection of cells of neuronal origin with mutants incapable of expressing γ34.5 results in shut-off of cellular protein synthesis, with the resultant limitation of viral production.

[0063] In summary, in the presence of y .5. HSV will prevent apoptosis, thus allowing for production of progeny viruses. In its absence, the cell dies and the infecting HSV cannot generate progeny viruses. Thus, HSV infection/propagation throughout an organ is eliminated.

[0064] The nestin promoter/V34.5 approach of the invention, thus allows for production of virus in cells that can use that promoter, but cells t at cannot turn on the promoter will not propagate infection.

[0065] The herpes viral mutant of the invention comprises a deletion or inactivating mutation in both copies of the γ34.5 gene, wherein at least one copy of the γ34.5 gene is reintroduced under the control of a cell-specific or tumor- pecific promoter.

[0066] As used herein, the term "deletion" is intended to mean the elimination of nucleic acids from a gene, such as the γ34.5 gene.

[0067] As used herein, the term "inactivating mutation" is intended to broadly mean a mutation or alteration to a gene wherein the expression of that gene is significantly decreased, or wherein the gene product is rendered nonfunctional, or its ability to function is significantly decreased.

[0068] The term "gene" encompasses both the regions coding the gene product as well as regulatory regions for that gene, such as a promoter or enhancer, unless othenvise indicated.

[0069] Ways to achieve such alterations include: (a) any method to disrupt the expression of the product of the gene or (b) any method to render the expressed gene

nonfunctional. Numerous methods to disrupt the expression of a gene are known, including the alterations of the coding region of the gene, or its promoter sequence, by insertions, deletions and/or base changes. (See, Roizman, B. and Jenkins, F. J., Science 229: 1208-1214 (1985)).

[0070] We have generated an improved oncolytic rQNestin34.5 HSV vims, a second generation virus referred to as rQNestin34.5.v2. The genetically modified HSV1

rQNestin.34,5.v2 has been made glioma- selective by the following maneuvers: 1) one of the viral genes that encodes for a viral protein (ICP6) has been removed. Without this gene, HSV1 has to utilize factors within the infected cells to efficiently grow and replicate and we have shown that such factors are existent in cells that are mitotically active or that have a. defect in a cellular gene (p i 6) that is missing in most gliomas; and 2) the two copies of the viral gene that encode for a protein (ICP34.5) needed for robust viral growth in an infected cell have also been removed and one copy was reinserted under control of a Nestin promoter that is also present selectively in gliomas in the adult, human brain. These two maneuvers thus allow this new HSV1 (designated as rQNestin34.5v.2) to be relatively selective in destroying gliomas and not normal brain ceils and we have confirmed these statements in cultured cells and in animal models. In addition, there is lack of an ICP6-EGFP fusion protein present in the first generation

rQNestiii34.5 (Kambara et al. An oncolytic HSV-1 mutant expression ICP34.5 under control of a Nestin promoter increases survival of animals even when symptomatic from a brain tumor, (2005) Cancer Res. 65(7): 2832-2839) , further removing a source of genomic instability and toxicity

[0071] Accordingly, provided herein are tumor-selective oncolytic herpes viral vectors comprising: a) a deletion or inactivating mutation in both copies of the gene encoding γ35.5; b) an insertion of at least one copy of the HSV γ35.5 gene under the transcriptional control of a Nestin promoter; and c) a deletion or inactivating mutation in the gene that encodes for the HSV viral protein ICP6, wherein the tumor-selective oncolytic herpes viral vector does not express green fluorescent protein, e.g. ICP6-EGFP fusion protein present in the first generation HSV-1 vector rQNestin34.5.

[0072] In certain embodiments, the vector does not contain UL39 nucleic acid regulatory sequences (promoter and enhancer elements). In certain embodiments, the vector does not contain a fusion protein of ICP6.

[0073] In one embodiment, the at least one copy of the γ35.5 gene under the

transcriptional control of a nestin promoter is inserted into UL39 gene that encodes for the large subimit of ribonucleotide reductase ICP6 (infected cell protein 6). In one embodiment, the nestin promoter comprises SEQ ID NO: 2 or a degenerate variant thereof. In one embodiment, a hybrid promoter comprising a nestin promoter and elements of heat shock protein 68 promoter is used {See Kambara et al . An oncolytic HSV- 1 mutant expression ICP34.5 under control of a ^' Nestin promoter increases survival of Animals even when symptomatic from a brain tumor, (2005) Cancer Res. 65(7): 2832-2839; and Kawaguchi et al .Nestin EGFP transgenic mice, visualization of the self-renewal and muitipotentcy of CNS stem cells Mol. Cell Neurosci.

(2001)17:259-273, incorporated by reference in their entirety).

[0074] In one embodiment, the tumor-selective oncolytic herpes viral vector comprises the sequence of SEQ ID NO: 1, or a degenerate variant thereof.

[0075] One of skill in the art would readily appreciate that a modified version of sequences disclosed herein could also be used, so long as it retains similar biological activity. Merely by way of non-limiting example, the nestin 2 ^nd intron sequence (enhancer) represented in SEQ ID NO: 4, and the hsp68 minimum promoter represented in SEQ ID NO: 5, could be used alone or combined when designing various constructs contemplated herein. In some

embodiments, the nestin enhancer element may be operably linked to a heat shock protein 68 (hsp68) minimum promoter to drive the expression of γ34.5. In some embodiments, alternative or additional expression control sequences may be incorporated into the oncolytic expression vectors to initiate or influence the expression of any of the aforementioned nucleotide sequences of interest. Merely by way of non-limiting examples, the nestin promoter may incorporate microRNA target sequences. Examples of miR translational control sequences include, but are not limited to: miR128 or miR124 to differentiate glioma cells from normal neural cells.

[0076] In various embodiments, the present invention provides a method for treating a neoplastic disease in a subject. In certain embodiments, the method includes administering to the subject a therapeutically effective amount of an expression vector with oncolytic activity. In some embodiments, the cancer is brain cancer. Merely by way of non-limiting examples, the types of brain cancer that can be treated may include glioblastoma, anaplastic astrocytoma, astrocytoma, pilocytic astrocytoma, diffuse intrinsic pontine glioma, oligodendroglioma, anaplastic oligodendroglioma, mixed oligo-astrocytoma, and pendymoma. In some

embodiments, cancer stem cells are treated with the inventive method. In some embodiments, the subject treated is a mammal. In certain embodiments, the subject treated is a human.

[0077] Methods of treating any of the neoplastic diseases described herein, including brain cancer, may include administration of the compounds of exemplary embodiments as a single active agent, or in combination with additional methods of treatment including, but not limited to, stem cell-based therapy, immunotherapy, radiation therapy, therapy with immunosuppressive agents, chemotherapeutic or anti-proliferative agents, including cytokines. The methods of treatment of the invention may be in parallel to, prior to, or following additional methods of treatment.

[0078] "Therapeutic benefit," as used herein, includes any decrease in cancer cell number, cancer cell proliferation rate, or metastasis. In some embodiments, the promoter used herein facilitates selective or increased expression of the associated gene of interest in one or more cancer cell type of interest, compared to a normal cell.

[0079] The term "operably linked," as used herein, refers to the arrangement of various nucleic acid molecule elements relative to each other such that the elements are functionally connected and are able to interact with each other. Such elements may include, without limitation, a promoter, an enhancer, a polyadenylation sequence, one or more introns and/or exons, and a coding sequence of a gene of interest to be expressed. The nucleic acid sequence elements, when operably linked, can act together to modulate the activity of one another, and ultimately may affect the level of expression of the gene of interest, including any of those encoded by the sequences described above.

[0080] One of skill in the art will understand that although specific sequences are provided herein, the nucleic acid molecules used in the inventive vectors, compositions and methods are not limited strictly to molecules including the sequences set forth as SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8. Rather, specific embodiments encompass nucleic acid molecules carrying modifications such as substitutions, small deletions, insertions, or inversions. Included in the invention are nucleic acid molecules, the nucleotide sequence of which is at least 95% identical (e.g., at least 96%, 97%, 98%, or 99% identical) to the nucleotide sequence shown as SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7 and 8 in the Sequence Listing.

[0081] Also included in the invention is a nucleic acid molecule that has a nucleotide sequence which is a degenerate variant of a nucleic acid disclosed herein, e.g., SEQ ID NOS: I, 2, 3, 4, 5, 6, 7, and 8. A sequential grouping of three nucleotides, a "codon," encodes one amino acid. Since there are 64 possible codons, but only 20 natural amino acids, most amino acids are encoded by more than one codon. This natural "degeneracy" or "redundancy" of the genetic code is well known in the art. It will thus be appreciated that the nucleic acid sequences shown in the Sequence Listing provide only an example within a large but definite group of nucleic acid sequences that will encode the polypeptides as described above.

[0082] Importantly, the vectors of the embodiments described herein may be useful for the introduction of additional genes in gene therapy. Thus, for example, the HSV vectors of this invention may contain one or more additional exogenous gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or a biologically active variant thereof, or in inducing cell death, such as the conditional suicide gene thymidine kinase, the latter must be used in conjunction with a thymidine kinase metabolite in order to be effective, or any other anti-tumor gene, such as for example a toxin.

[0083] When used pharmaceutically, oncolytic vector embodiments discussed herein can be combined with various pharmaceutically acceptable carriers. Suitable pharmaceutically acceptable carriers are well known to those of skill in the art. The compositions can then be administered therapeutically or prophylactically, in effective amounts, described in greater detail below.

[0084] As used herein, the term "therapeutically effective amount" is intended to mean the amount of vector which exerts oncolytic activity, causing attenuation or inhibition of tumor cell proliferation, leading to tumor regression. An effective amount will vary, depending upon the pathology or condition to be treated, by the patient and his or her status, and other factors well known to those of skill in the art. Effective amounts are easily determined by those of skill in the art. In some embodiments a therapeutic range is from 10 ³ to 10 ¹² plaque forming units introduced once. In some embodiments a therapeutic dose in the aforementioned therapeutic range is administered at an interval from every day to every month via the intratumoral, intrathecal, convection-enhanced, intravenous or intra-arterial route.

[0085] Although certain routes of administration are provided in the foregoing description, according to the invention, any suitable route of administration of the vectors may be adapted, and therefore the routes of administration described above are not intended to be limiting. Routes of administration may including but are not limited to, intravenous, oral, buccal, intranasal, inhalation, topical application to a mucosal membrane or injection, including intratumoral, intradermal, intrathecal, intracisternal, intralesional or any other type of injection. Administration can be effected continuously or intermittently and will vary with the subject and the condition to be treated. One of skill in the art would readily appreciate that the various routes of administration described herein would allow for the inventive vectors or compositions to be delivered on, in, or near the tumor or targeted cancer cells. One of skill in the art would also readily appreciate that various routes of administration described herein will allow for the vectors and compositions described herein to be delivered to a region in the vicinity of the tumor or individual cells to be treated. "In the vicinity" can include any tissue or bodily fluid in the subject that is in sufficiently close proximity to the tumor or individual cancer cells such that at least a portion of the vectors or compositions administered to the subject reach their intended targets and exert their therapeutic effects.

[0086] Pharmaceutically acceptable carriers are well known in the art and include aqueous solutions such as physiologically buffered saline or other solvents or vehicles such as glycols, glycerol, vegetable oils (e.g., olive oil) or injectable organic esters. A pharmaceutically acceptable carrier can be used to administer the compositions of the invention to a cell in vitro or to a subject in vivo. A pharmaceutically acceptable carrier can contain a physiologically acceptable compound that acts, for example, to stabilize the composition or to increase the absorption of the agent. A physiologically acceptable compound can include, for example, carbohydrates, such as glucose, sucrose or dextrans, antioxidants, such as ascorbic acid or glutathione, chelating agents, low molecular weight proteins or other stabilizers or excipients. Other physiologically acceptable compounds include wetting agents, emulsifying agents, dispersing agents or preservatives, which are particularly useful for preventing the growth or action of microorganisms. Various preservatives are well known and include, for example, phenol and ascorbic acid. One skilled in the art would know that the choice of a

pharmaceutically acceptable carrier, including a physiologically acceptable compound, depends, for example, on the route of administration of the polypeptide.

[0087] Some embodiments of the technology describedHSF herein can be defined according to any of the following numbered paragraphs:

Paragraph 1. A tumor-selective oncolytic herpes viral vector, comprising:

(a) a deletion or inactivating mutation in both copies of the gene encoding γ34.5, and (b) an insertion of at least one copy of the HSV γ34.5 gene under the transcriptional control of a Nestin promoter; and

(c) a deletion or inactivating mutation in the gene that encodes for the HSV viral protein ICP6, wherein the tumor-selective oncolytic herpes viral vector does not express green fluorescent protein.

Paragraph 2. The tumor-selective oncolytic herpes viral vector of paragraph 1, wherein the vector does not contain UL39 nucleic acid regulator} ⁷ sequences.

Paragraph 3 , The tumor-selective oncolytic herpes viral vector of any of paragraphs 1-2, wherein the vector does not contain a fusion protein of ICP6.

Paragraph 4. The tumor-selective oncolytic herpes viral vector of any of paragraphs 1-3, wherein the at least one copy of the γ34.5 gene under the transcriptional control of a nestin promoter is inserted into UL39 gene that encodes for the large subunit of ribonucleotide reductase ICP6.

Paragraph 5. The oncolytic expression vector of any of paragraphs 1-4, wherein the nestin promoter comprises SEQ ID NO: 2 or a degenerate variant thereof.

Paragraph 6. The tumor-selective oncolytic herpes viral vector of paragraph 1, wherein the vector comprises the sequence of SEQ ID NO: 1 or a degenerate variant thereof.

Paragraph 7, A method for selectively killing intracranial tumor cells in a subject, comprising introducing into the vicinity of the tumor-selective oncolytic herpes viral vector of any of paragraphs 1-6.

Paragraph 8. The method of paragraph 7, further comprising the administration of cyclophoshamide (CPA).

Paragraph 9. The method of any of paragraphs 7-8, wherein the CPA is administered two days before the oncolytic herpes viral vector.

Paragraph 10. The method of any of paragraphs 7-9, wherein the tumor cells comprise a glioblastoma ceil.

Paragraph 1 1. The method of any of paragraphs 7-10, wherein the tumor cells comprise a cancer stem cell.

Paragraph 12. The method of any of paragraphs 7-11, wherein the subject is a mammal. Paragraph 13. The method of any of paragraphs 7-12, wherein the subject is a human. Paragraph 14. A tumor-selective oncolytic herpes viral vector for use in the treatment of intracranial tumor cells in a subject, said tumor- selective oncolytic herpes viral vector comprising:

(d) a deletion or inactivating mutation in both copies of the gene encoding γ34.5; and

(e) an insertion of at least one copy of the HSV γ34.5 gene under the transcriptional control of a nestin promoter; and

(f) a deletion or inactivating mutation in the gene that encodes for the HSV viral protein ICP6, wherein the tumor-selective oncolytic herpes viral vector does not express green fluorescent protein.

Paragraph 15. The tumor-selective oncolytic herpes viral vector of paragraph 14, wherein the vector does not contain UL-39 nucleic acid regulator}' sequences.

Paragraph 16. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

15, wherein the vector does not contain a fusion protein of ICP6.

Paragraph 17. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

16, wherein the at least one copy of the γ34.5 gene under the transcriptional control of a nestin promoter is inserted into UL39 gene that encodes for the large sub unit of ribonucleotide reductase ICP6.

Paragraph 18. The oncolytic expression vector of any of paragraphs 14-17, wherein the nestin promoter comprises SEQ ID NO: 2 or a degenerate variant thereof.

Paragraph 19. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

18, wherein the vector comprises the sequence of SEQ ID NO: 1 or a degenerate variant thereof.

Paragraph 20. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

19, wherein the tumor cells comprise a glioblastoma cell.

Paragraph 21. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

20, wherein the tumor cells comprise a cancer stem cell.

Paragraph 22. The tumor-selective oncolytic herpes viral vector of any of paragraphs 14-

21, wherein the subject is a mammal.

Paragraph 23. The tumor- selective oncolytic herpes viral vector of any of paragraphs 14-

22, wherein the subject is a human. Paragraph 24. The tumor-selective virus of any of paragraphs 1-23, wherein the vector does not comprise SEQ ID NO: 7.

Paragraph 25. The tumor-selective virus of any of paragraphs 1 -23, wherein the vector comprises SEQ ID NO: 8.

Paragraph 26. The use of the tumor-selective virus of any of paragraphs 1-25 for selectively killing intracranial tumor cells in a subject.

Paragraph 27. The use of paragraph 26, wherein cyclophosharnide (CPA.) is administered to the subject.

Paragraph 28. The use of any of paragraphs 26-27, wherein the CPA is administered two days before the oncolytic herpes viral vector.

Paragraph 29. The use of any of paragraphs 26-28, wherein the tumor cells comprise a glioblastoma cell.

Paragraph 30. The use of any of paragraphs 26-29, wherein the tumor ceils comprise a cancer stem cell.

Paragraph 31. The use of any of paragraphs 26-30, wherein the subject is a mammal.

Paragraph 32. The use of any of paragraphs 26-31, wherein the subject is a human.

Paragrph 33. A tumor-selective oncolytic herpes viral vector that consists essentially of SEQ ID NO: 1.

EXAMPLES

[0088] The following examples are included to demonstrate preferred embodiments of the invention. It should be appreciated by those skilled in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventors to function well in the practice of the invention, and thus can be considered to constitute preferred modes for its practice. However, those of skill in the art should, in light of the present disclosure, appreciate that many changes can be made in the specific embodiments which are disclosed and still obtain a like or similar result without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain agents that are both chemically and

physiologically related may be substituted for the agents described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

Example 1 Generation of rQNestin34.5v.2

[0089] rQNestin34.5v.2 is a genetically engineered HSV1 (F strain derivative), designed to replicate in glioma cells and not normal cells in the brain or other tissues. HSV1 is present endemically in the human population primarily in a latent form within the sensory neurons of the trigeminal ganglia. The virus is approximately 152-158 kilobases, it is enveloped and measures 150 nm in diameter. The virus will infect and replicate in most, if not all, established human glioma cell lines, as well as freshly established gliomas from patients expanded under conditions that enrich for the "stem-like" glioma subpopulation. The following genetic modification were made to HSV1 F strain ( e.g. commercially available form OriGene Technologies Inc.

Rockville, MD 20850 U.S.S) to generate rQNestin34.5v.2:

1- Both endogenous copies of the coding region of the viral gene encoding for ICP34.5 have been mostly removed;

2- A single copy of the ICP34.5 coding region was placed under control of a glioma-selective nestin promoter/enhancer sequence, providing glioma- selective expression of the ICP34.5 viral gene, allowing for more robust replication of the virus in nestin-expressing glioma vs. nestin-non expressing brain cells;

3- The viral ICP6 gene locus is also disrupted, restricting viral replication to glioma cells with defective pl6 tumor suppressor pathway signaling (> 90% of gliomas) or mitotic cells.

[0090] The schematic of rQNestin34.5v.2 is shown if Figure 1. In infected cells, viral

DNA remains extrachromosomal. The virus, upon entry in tumor cells will enter the lytic cycle, usually resulting in tumor cell lysis within 12-18 hours. Latency only occurs in trigeminal sensory neurons.

[0091] rQNestin34.5 v. 2 DNA was subjected to next generation sequencing on an

Illumina GA He machine at the Microarray Core Facility Huntsman Cancer Institute University of Utah, the Sequence is provided in SEQ ID NO: 1. [0092] The nestin-hsp68 minimum enhancer/promoter sequence are derived from the human nestin enhancer/promoter and the human hsp68 promoter fused together to provide specific transcriptional regulation to cells expressing nestin. Specific transcriptional regulation of ICP34.5 in the context of rQNestin was shown in the following set of experiments (Note: ICP34.5 expression in infected cells is leads to dephosphorylation of the translation factor eIF2a. Therefore, we would expect to see dephosphorylated eiF2a in glioma cells that express nestin, while cells that do not express nestin (HUVEC and human astrocytes) should have high levels of phosphor eiF2a, after viral infection).

[0093] Several established glioma cell lines (U87dEGFR, U215, U138 and

Gli36dEGFR), a freshly explanted glioma cell grown under conditions to enrich for the glioma "stem-like" cell subpopulation (GBM #02), normal human vein endothelial cells (HUVEC) and normal human astrocytes were infected with rQNestin34.5 v.2 or another rQNestin34.5 (v. l- that expressed GFP) (Figure 2). In addition, rHSVQl (rQl) (see e.g. US 20020110543 and

Hirokazu Kambara et al. An Oncolytic HSV-1 Mutant Expressing ICP34.5 under Control of a Nestin Promoter Increases Survival of Animals even when Symptomatic from a Brain Tumor, Cancer Res April 1, 2005, 65; 2832), an ICP34.5 deleted mutant, wild-type F strain virus, and uninfected cells were also used. Cell lysates were separated and Western blots for eIF2a vs. phosphor-eiF2a were then performed. In normal HUVEC cells and astrocytes, phospo-eiF2a was present, as expected, in rQNestin34.5, rQNestin34.5v.2, and rHSVQl virally-infected cells, showing that they functioned as ICP34.5 mutants, while no phosphor-eiF2a was observed in wild-type F strain infected cells. However, in all glioma cells, there was no phosphor-eiF2a detected in in rQNestin34.5 or rQNestin34.5v.2 infected cells, similar to wild-type F strain virus, while phosphor-eiF2a was still visible in rHSVQl -infected cells. This data thus showed that rQNestin34.5v.2 functioned as an ICP34.5 -defective virus in normal cells (HUVEC and astrocytes) unlike wild-type virus. However, in glioma cells, rQNestin34.5v.2 functioned as an ICP345. -positive virus, similar to wild-type virus. Quantitatively, there was clearly a >2-fold decrease in the levels of phosphorylated eiF2a in glioma cells infected with rQNestin34.5v.2 and parental rQNestin34.5 compared to control rHSVQl virus. Also, the levels of observed phosphorylated eIF2a in the rQNestin34.5v.2 and parental rQNestin34.5 infected glioma cells were >2-fold less than unphosphorylated eIF2a protein in the same cells. [0094] In the first series of steps, we had to modify fHSVQuik-1, the bacterial artificial chromosome (BAC) that contains the F strain HSV1 sequence with the deleted diploid ICP34.5 genes. The generation of fHSVQl was described in Terada et al. (Terada et al. Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using synergenic mouse tumor models. Gene Ther. 13 : 705-714, 2006). Figure 3 shows that the modification of fHSVQuik-1 to remove the entire sequence of EGFP under control of the ICP6 promoter was accomplished by ET-cloning of a GmR selection marker at the site with removal of the ICP6 promoter-EGFP transcriptional cassette, followed by FLP-recombination and removal of the selectable marker to generate fHSVQuik-2. In order to transfer in the

Nestin/hsp68 promoter/enhancer- ICP34.5 cassette into fHSVQuik-2, a transfer plasmid with this cassette (marked in X) is then recombined back into the same site using Flp-recombinatiion to give rise to fHsvQ2-X. When X is the Nestin/hsp68 promoter/enhancer- ICP34.5 cassette, it is designated as fHSVQ2-nestin34.5 (see Figure 4)

[0095] After generating fHSVQ2-nestin34.5 in bacteria, the entire BAC is purified and electroporated into mammalian Vero cells where Cre-Lox recombination is utilized to remove all BAC sequences (figure 4). The viral genome is now "free" to begin its own process of DNA replication, generating viral plaques that can be purified to generate rQNestin34.5v.2. The generated rQnestin34.5v.2 was identified by Southern blotting as possessing the desired genetic identity (data not shown). An isolate of rQNestin34.5v.2 was then sent to Diamyd, Inc. who proceeded with viral DNA isolation and transfection into their certified Vero derived Master Cell Bank (MCB) followed by expansion to obtain the final seed of rQNestin34.5v.2 employed for subsequent efficacy/toxicity experiments. This Viral Seed Stock (VSS) was subjected to a panel of validated assays in order to allow subsequent cGMP procedures moving toward large scale manufacturing of the vector for the clinical trial. The VSS tests performed under validated GLP conditions included; Sterility (including Bacteristasis and Fungistasis (B&F) immersion), Mycoplasma (Points to Consider), Endotoxin, Polymerase Chain Reaction (PCR) based Reverse Transcription (PBRT) assay, and quantitative PCR (QPCR) testing for the following adventitious agents: Porcine Circovirus 1 and 2; Adenovirus type 5; Adeno- Associated Virus types 1, 2, 3, 4, 6, 7, 8, 9, 10, and 11. The results of this testing panel document the suitability to advance with manufacturing. [0096] Virus production

[0097] Cell Thaw and Expansion. One or more vials of VeroD Master Cell Bank are thawed at 37°C and the cells are transferred to a conical tube and pooled. The cells were vialed at 1.2x l0 ⁷ cell/mL/tube and viable recoveries have been ~ 9.2>< 10 ⁶ cell/tube. The cells were gradually diluted with complete medium and a sample is removed to obtain viable cell counts. The cells are plated to flasks at a density of 3.0 - 5. Ox 10 ⁴ cells/cm2.

[0098] The cells were incubated at 37°C, 7.5% C0 ₂ and examined periodically by phase microscopy for growth and visual evidence of microbial contamination. When the cells were -80% confluent, the cells were passaged. Briefly, the complete medium is removed and PBS is added to rinse the cells. The PBS is removed and TryPLE Select is added to the flasks to dissociate the cells. The flasks are incubated at 37°C for approximately 3-5 minutes or until the cells are detached. The cells were re-suspended in complete medium, pooled, counted and seeded into new flasks at a density between 2.0-4. Ox 10 ⁴ cells/cm ² . The cells were expanded to 16x 10-layer Nunc Cell Factories and allowed to reach 1-2 days post confluence prior to infection, allowed to reach 1-2 days post confluence prior to infection.

[0099] Infection with rQNestin34.5v.2 Vector. When the cells have reached desired confluence, an example flask was treated with TryPLE Select and counted to estimate cell numbers. The rQNestin34.5v.2 Master Virus Bank vector inoculum was prepared by thawing the appropriate volume required to obtain an MOI=0.1. The cell factories were infected by an initial 1.5 hour adsorption period followed by incubation for the first day of infection in complete medium. After -24 hours, the culture medium was removed and replaced with an equal volume of serum-free medium. The cell factories were placed in the incubator and the temperature is reduced to 33°C/ 7.5%C02. The cultures were monitored daily and checked visually for percent cytopathic effect. The infection typically lasts for 4 days.

[00100] Crude Viral Harvest and Clarification. The infection was stopped by placing the cell factories in the biosafety cabinet and pooling the supernatant and cell debris into a sterile bag. The harvest sodium chloride level was increased to 0.45 M by the addition of a 5 M NaCl stock solution. The harvest was then mixed by hand for 20-30 minutes. The harvest was then aliqotted into 500 mL centrifuge tubes and the cell debris is removed by centrifugation at 1500xg. The supernatant was repooled into a sterile bag. After pre-treatment of a Sartopore clarification filter capsule with sterile water, the virus-containing supernatant was then pumped through the filter capsule into another sterile bag. The virus is followed by pumping sterile water to recover remaining virus in the capsule. The bag was mixed and the filtrate is stored overnight at 4°C.

[00101] The next day, the filtrate was warmed and adjusted to ~2mM MgCl ₂ by addition of 2 volumes of 3mM MgCl ₂ in sterile water. The diluted filtrate is mixed and Benzonase treatment is performed next. This is done by first diluting 100,000-200,000 U of the enzyme into dilution buffer and 7 sequential additions are injected at 5 minute intervals with continuous mixing over a 35 minute period.

[00102] Cation Exchange Column Chromatography. A BPG 100 column is packed with

SP high performance resin and is sanitized with 0.5N NaOH. After sanitization, the column is equilibrated with wash buffer (PBS pH 7.0), strip buffer (1M NaCl-PBS pH 7.0), and wash buffer before loading benzonase treated virus. Conductivity, UV, and pH are monitored during the run.

[00103] The process bag containing the Benzonase treated filtrate was connected to the inlet using a tubing welder and the virus is loaded onto the column. The flow through was collected in a sterile bag. The virus capture step was followed by washing with PBS pH 7.0 until the UV absorbance returns to baseline. The pump was stopped and the process bag containing 0.45 M NaCl-PBS pH 7.0 was connected to the inlet. The outlet tubing was transferred to a sterile container in the biosafety cabinet. The buffer was pumped into the column and when the UV absorbance began to increase sharply, the column outlet was transferred to a new sterile container to collect the eluted virus. The collection was stopped after the UV absorbance returns to near baseline. This is the purified viral elute fraction. The process bag containing strip buffer is next connected to the inlet. The end of the outlet tubing is transferred into a sterile bottle to collect the strip fraction. The buffer is pumped through the column until UV absorbance reaches a peak and returns to near baseline. The elute is stored at 4°C overnight.

[00104] Tangential Flow Filtration and Final Filtration. The tangential -flow filtration system is prepared by assembling the tubing and cartridge and sterilizing the system by autoclaving. The system is transferred to the biosafety cabinet and flushed with sterile PBS pH 7.0. An equal volume of sterile PBS pH 7.0 and the 0.45M virus elute fraction are added to the system reservoir and recirculated for 5-10 minutes. After this equilibration, the permeate collection pump is turned on and filtrate is collected at ~5 mL/minute. The system is run until the loaded volume is reduced by half. The retentate in the reservoir is diluted with PBS pH 7.0 to double the volume and continued to reconcentrate. This process is repeated while monitoring the conductivity of the permeate. When the permeate conductivity was within 10% of the diafiltering buffer (PBS pH 7.0) the product was allowed to concentrate to about 40 mL The retentate was recovered and filtered through a 0.45 um Millipack filter unit.

[00105] Final Formulation and Packaging. The terminal filtered virus stock was adjusted to 10% final volume with sterile glycerol and mixed well. The product was manually dispensed into cryovials for storage at a volume of 110 uL per vial. The tubes were labeled and stored at <- 65°C.

[00106] Example! Preclinical Studies

[00107] Three general sets of experiments were performed. In the first, in vitro studies utilizing glioma cell lines and normal human cells (particularly human astrocytes) are utilized as models to show the relative selectivity of rQNestin34.5 replication and cytotoxicity against the former and not the latter. In the second, a mouse athymic model of intracranial human glioma xenograft is used to show that a single intratumoral injection of rQNestin34.5v.2 leads to a significant prolongation of animal survival. Due to the lack of replication of the virus in syngeneic murine gliomas grown in C57/B6 mice, a suitable efficacy experiment in an immunocompetent animal model is not possible. Finally, intracranial injections of the agent in the brains HSV-susceptible Balb/c mice were performed to determine the degree of toxicity

[00108] We first determined if rQNestin34.5v.2 replicated efficiently in human glioma cells vs. normal human astrocytes. The former express nestin while the latter do not (data not shown). Figure 2 shows that nestin promoter activation of ICP34.5 in rQNestin34.5 infected glioma cells led to dephosphorylation of the translation factor eiF2a thus allowing for efficient translation of viral mRNAs in infected cells, similar to wild-type F strain, while ICP34.4-deleted HSV1 (such as Ql, aka rQl, rHSVQl) cannot do this. Therefore, one would expect in human glioma cells robust replication of rQNestin34.5v.2 similar to F strain, while Ql should replicate poorly. Figure 5 confirms this. Conversely, in normal human astrocytes (the predominant cell population in the brain, whose progenitor is thought to give rise to glioma) that do not express nestin, rQNestin34.5v.2 will not dephosphorylate eiF2a, leading to poor to nil viral replication, similar to other ICP34.5-deleted HSV1 such as Ql (Figure 5). Wild-type F strain HSV1 will still replicate though. In fact, As shown in Figure 4, the yield of rQNestin34.5v.2 was at least 4 log units more in U87dEGFR and 5 log units more in U251 compared to that in human astrocytes (where it approached almost no virus obtained). We then tested the cytotoxicity of rQNestin34.5v.2 against a panel of human glioma cells and normal human cells. rQNestin34.5 v.2 was added to panels of gliomas cells and normal human and mouse cells to a MOI of 0.1 (Figure 6). Five days later, surviving cells were counted. There were < or = 20% of glioma cells alive and > or = 80% normal cells alive at this time point. The sum of these experiments thus established the relative selectivity in replication and toxicity of rQNestin34.5v.2 against human glioma vs. normal cells.

[00109] We then employed an orthotopic model of human glioma growth in athymic mice. For this, we utilized human U87dEGFR glioma cells that usually establish after a few days of intracerebral inoculation and lead to animal death by 3-4 weeks. In the first experiment, rQNestin34.5v.2 was inoculated seven days after tumor cell inhection (Figure 7A), while in the second the virus was injected 14 days later, as animals become symptomatic from tumor growth (Figure 7B). In both cases, the virus was injected at a dose of 3 x 105 pfus. In both, there was a significant increase in mouse survival, indicating that rQNestin34.5v.2 was an effective antiglioma agent in this mouse model.

[00110] Finally, we tested the relative safety of rQNestin34.5v.2 by direct intracerebral inoculation into the brains of Balb/c mice that are relatively sensitive to HSV-induced encephaliti s/meningiti s

[00111] Table 1 in Figure 8 summarizes the results of all experiments to date with Balb/c mice. Intracerebral injection of 10 ⁷ pfus in either 8 week old or 6 month old mice was well tolerated (32/33, with one death at day 3 post-injection for unknown reasons). In contrast, F strain caused death in 5/animals at 6, 6, 7, 8, and 12 days after injection. Intrathecal, intrahepatic and intravenous injections of rQNetsin34.5v.2 were also well tolerated without deaths at a dose of 10 ⁷ pfus, although F strain also did not cause death by these routes.

[00112] The sum of these experiments thus indicates that rQNestin34.5v.2 is selectively toxic for human glioma cells vs. normal cells including astrocytes, leads to a prolongation of survival in animal models of gliomas at a dose of 3 x 10 ⁵ pfus, and 97% of Balb/c mice survive an intracranial injection at a dose of 10 ⁷ pfus, while less than 30% of mice survive an intracranial injection of wild-type F strain at a dose of 10 ⁵ pfus.

[00113] Brief description of cloning to remove GFP region

[00114] We generated PCR-del-GFP-FRT-Gm-F&R DNA (SEQ ID NO: 8) by PCR amplification. We then performed homologous recombination of this PCR product with fHSVQuik-1 BAC vector using ET-recombination technique, resulting in the replacement of Figure 15 region schematic (SEQ ID NO: 7) to Figure 16 schematic, sequence (SEQ ID NO: 8). We then Transformed Flp-T vector in E.coli containing above BAC vector to remove the region surrounded by two FRT sites, one of which locates in original fHSVQuik-1 BAC vector. This resultant vector is called fHSVQuik-2.

[00115] In vivo replication

[00116] Replication of rQNestin34.5v.2 (v2) was analyzed in 5 glioma stem cells (brain tumor initiating cells - BTIC) freshly generated from humans (G35, G68, G97, OG02, X12). HSVQ1 (Ql) an ICP34.5 deleted virus showed no or minimal replication. F (wild-type HSV) showed the most replication. 34C is an unrelated HSV recombinant HSV. We utilize athymic mice (nu/nu) where implantable human glioma cells (human U87EGFR or Gli36dEGFR) are grown. This model has been widely utilized by us and others to monitor efficacy. These tumors reliably form in animal brains leading to their death within 3-4 weeks. These cells are

histologically similar to human glioma cells and the tumors are highly vascular like the clinical tumors. The major difference is that they are not as invasive as the clinical gliomas. We have also shown efficacy in glioma cells freshly excised from humans with tumors and grown to enrich for the glioma stem-like cell population (Figure 9).

[00117] Injected mice have been kept alive for at least 60 days. In addition, we have conducted biodistribution studies in athymic and Balb/c mice after intracerebral (i.e.) , intravenous (i.v.) or intrathecal (i.t.) inoculation of rQNestin34.5v.2 or F (wild-type) HSvl strain to detect a viral transcript (LAT) by RT-PCR, expressed during both lytic and latent phases of the viral life cycle. Figure 10 shows that the transcript was not detectable in the brain or trigeminal ganglia of either Nu/nu or Balb/c mice 60 days after i.e., i.t. or i.c, routes of administration of 10 ⁷ pfus of rQNestin34.5v.2. In contrast, there were some faint bands in all tested brain and trigeminal ganglia samples at the 30 and 60 day time point after i.e. administration of 10 ³ pfus of F strain.

[00118] In addition, we performed PCR for the HSV DNA polymerase gene. Figure 11 shows that copies of the gene were not detected in brains or trigeminal ganglia of mice after rQNetsin34.5v.2, indicating lack of active viral replication. In contrast, there was faint detection of DNA pol after injection of F strain, indicating some low level of DNA replication, particularly in brain.

[00119] Example 3 Utilization of a nestin Transcriptional enhancer /promoter

[00120] Nestin expression in human brain adjacent to gliomas and in human brain after treatment.

[00121] Amongst the several levels of tumor cell selectivity for rQNestin34.5v.2, one of significance, the nestin transcriptional element is composed of the nestin-hsp minimum enhancer/promoter sequence, derived from a the second intron/enhancer of the rat nestin gene enhancer fused to the mouse hsp68 promoter to provide specific transcriptional regulation to cells expressing nestin, including human cells. This construct provides selective expression of the viral ICP34.5 gene to nestin-expressing cells in the brain. The presence or absence of nestin in human brain adjacent to a malignant glioma or in human brain after malignant glioma treatment was confirmed by Nestin IHC in human brain adjacent to gliomas and in human brain after treatment.

[00122] An adult male older than 50 years underwent resection of a malignant glioma at the Ohio State University Medical Center. As part of the resection, brain adjacent to tumor that was devoid of gross tumor was also resected up to the lateral ventricle. This brain was stained for expression of GFAP (Figure 17A) and Nestin (Figure 17B-17D) at the Ohio State

University Medical Center Neuropathology Core. A second subject was also over 50 and had a malignant glioma resected and then underwent radiation and chemotherapy. He passed away from causes other than his tumor (Figure 18). The primary antibody was Nestin from Millipore at a 1 :500 dilution. Deparaffization and dehydration were performed as per routine. Antigen was exposed with standard heat -induced epitope retrieval methods. Slides were immersed in Target Retrieval Solution PH9 (DAKO) and microwaved until the solution came to a boil. Boiling was then carried out for 15min with lower power. After cooling the solution for about 30min, slides were rinsed in PBS. To inhibit internal peroxidase, slides were immerse in methanol with 0.3%H2O2 for 15min and then rinses in PBS-T. Blocking was carried out for lh at room temperature, before applying the primary antibody to human Nestin (Millipore) 1 :500 at 4 °C overnight. The secondary antibody was then applied at 1 :500 dilution, followed by DAPI staining and mounting of sections on slides. At autopsy, brain showed little if any nestin immunoreactivity. There was no Nestin immunopositivity in brain or in cells of the

ependyma/subependyma within the subventricular zone (SVZ), where neural stem cells usually reside. Therefore the evidence shows that a target population for a clinical trial (human adults with MG) exhibit little if any evidence for nestin expression in brain white matter where the MG usually resides or in the SVZ where neural stem cells are found. Instead, published evidence shows that the MG exhibits high levels of widespread nestin immunoreactivity.

[00123] Athymic mice studies related to nestin expression in brain.

[00124] To determine whether there was nestin expression in the brains of athymic mice, since these were the species selected for efficacy and toxicology /biodistribution studies, male and female athymic mice (6-8 week of age) were inoculated intracerebrally with the agent, rQNestin34.5v.2. However, one control group of mice (group 1) was inoculated intracerebrally with vehicle (PBS) alone. At day 4 after this PBS inoculation, mice were euthanized per protocol for brain analyses. It was determined whether there was nestin expression in the brain of one of these mice. Figure 19 shows nestin positive cells in tanicytes (ependymal cells) lining the lateral and third ventricle as well as the aqueduct. There was also nestin positivity in cells lining the fourth ventricle. The same experiment was performed with an animal from group 2 (preadministration of CPA followed by injection of PBS vehicle), to confirm the same pattern of nestin expression. In addition, nestin expression was seen in astrocytes around the needle tract, indicating up-regulation of nestin in reactive astrocytes in mice.

[00125] Example 4 In vitro characterization of rQNestin34.5v.2.

[00126] The viral yield of rQNestin34.5v.2. was determined. Cells (2 x 10 ⁵ ) were plated in 6-well plates. The following day, cells were infected with rQNestin34.5v.2 (v2), parental rHSVQl (Ql), or wild-type F strain (F) at MOI = 0.1. One hour after infection, cells were washed with glycine saline solution (10 mM glycine, 137 mM NaCl, 24.1 mM KC1, 0.49 mM MgC12. 0.68 mM CaC12, pH 3) followed by PBS to remove unattached viruses and fresh medium were added. Cells were incubated for 3 days at 37 °C in an atmosphere containing 5% C02. The cells and medium were collected, and subjected to three cycles of freeze/thaw with dry ice/Ethanol and 37 °C water bath. After pelleting cell debris by centrifugation (35000 x g, 10 min., 4 °C), supernatant was transferred to new tubes and stored at - 80 °C until titration. The titer of each sample was determined by conventional plaque assay with Vero cells. Figure 20 shows that the viral yield of rQnestin34.5v.2 was equivalent to that of rQNestin34.5 in 3 glioma cells, including a glioma stem-like cell and superior to that in HUVEC cells. The replication potential of rQNestin34.5v.2. was determined in multiple cell lines. Figure 21 shows that rQNestin34.5v.2 replication was higher than that of the ICP34.5 -negative rHSVQl in 4 established glioma cell lines and 3 primary gliomas grown under stem-like condition, but similar to rHSVQl in 4 normal cells. F strain replication was higher in all.

[00127] The cytotoxicity of rQnestin34.5v.2 was determined. rQNestin34.5v.2 was added to a panel of glioma cells, U87AEGFR (U87dE), U87, U251 and OG02 glioma "stemlike" cells and to a panel of normal cells, human astrocytes (HA), human fibroblasts (Fibro.), human smooth muscle (SM), human skeletal muscle cells (SkM) and mouse astrocytes (MA). Cells were seeded on 6-well plates in complete medium prepared by following manufacturer's instructions for normal primary cells, BTSC medium for primary glioma cells or DMEM supplemented with 2% FBS for glioma cell lines and allowed to adhere. The medium for normal cells were changed to basal medium a few hours after cell preparation. Next day, viruses were added at MOI=0.1. rQNestin34.5v.2 inactivated with UV radiation was used as mock control. One hour after infection, cells were washed with glycine saline solution (10 mM glycine, 137 mM NaCl, 24.1 mM KCl, 0.49 mM MgC12. 0.68 mM CaC12, pH 3) followed by PBS to remove unattached viruses and fresh medium were added. Cells were incubated at 37 °C in an atmosphere containing 5% C02. Five days after infection virus cytotoxicity was measured as surviving cells counted with a Coulter counter (Beckman Coulter). Figure 22 shows the cytotoxity of of rQnestin34.5v.2 and rQnestin34.5.

[00128] A clinical trial is planned that will be performed as a dose-escalation study.

Clinical outcome will be asssesed (overall survival after injection, progression-free survival after injection), radiologic outcome (regression of tumor visualized on MRI), and tissue analysis of viral biodistribution studied. The trial will be performed as a dose-escalation, starting at 10 ⁸ pfus (1ml volume, multiple injection sites). This dose was selected because 10 pfus appeared to be safe in a mouse brain. Since a mouse brain weighs about 1 gram, while the human barin weighs 1500 grams, this would translate to a safe dose of 5 x 10 ¹⁰ in a human. To further ensure safety, we thus will start by almost 3 logs less in humans. Dose-escalations will proceed by half- a -log up to 10 ¹⁰ pfus.

[00129] The maximum tolerated dose (MTD) will be defined as the dose one half-log order less than the dose level at which one-third of the patients have a dose limiting toxicity (DLT) of grade 3 or grade 4 (defined below) related to the administration of rQNestin34.5v.2. Cohorts of three patients will be administered with be escalated by half-log increments at each dose level until a dose limiting toxicity (DLT) is reached. If the MTD is not reached, the phase I dose will be the highest dose reached

[00130] A DLT will consist of: ' Any Grade 4 or 5 toxicity on the Common Terminology

Criteria for Adverse Events v4.0 (CTCAE) attributed to rQNestin34.5v.2, except for Grade 4 lymphocyte, neutrophil, white blood count decrease on the investigation category of CTCAE v4.0. ' Grade 3 toxicity for encephalitis, encephalomyelitis, meningitis infections/infestations categories on CTCAE v4.0 attributed to rQNestin34.5v.2. ' Grade 3 toxicity for Nervous System disorder category on the CTCAE v4.0 relative to the changes from the pre-treatment

neurological status attributed to rQNestin34.5v.2: ataxia, depressed level of consciousness, encephalopathy, extrapyramidal disorder, hydrocephalus, intracranial hemorrhage,

leukoencephalopathy, myelitis, pyramidal tract syndrome, somnolence, stroke. ' Grade 3 toxicity for Psychiatric disorder category on CTCAE v4.0 relative to changes from the pre-treatment status attributed to rQNestin34.5v.2: delirium, hallucinations, psychosis.

[00131] The first patient in each cohort will be observed for at least 10 days following injection with rQNestin34.5v.2 prior to the next patient being enrolled into the study protocol. If there is no DLT, then the second and third patient will be accrued at the same dose. Patients will only be enrolled into the next dose level if 1/3 DLT is not reached based on CTCAE v.4.

[00132] The determination of DLT and MTD will be separate for arm A and arm B since the gliomatous mass will have been largely resected in the former and not the latter and, thus, may lead to toxicities at different doses. [00133] The various methods and techniques described above provide a number of ways to carry out the application. Of course, it is to be understood that not necessarily all objectives or advantages described can be achieved in accordance with any particular embodiment described herein. Thus, for example, those skilled in the art will recognize that the methods can be performed in a manner that achieves or optimizes one advantage or group of advantages as taught herein without necessarily achieving other objectives or advantages as taught or suggested herein. A variety of alternatives are mentioned herein. It is to be understood that some preferred embodiments specifically include one, another, or several features, while others specifically exclude one, another, or several features, while still others mitigate a particular feature by inclusion of one, another, or several advantageous features.

[00134] Furthermore, the skilled artisan will recognize the applicability of various features from different embodiments. Similarly, the various elements, features and steps discussed above, as well as other known equivalents for each such element, feature or step, can be employed in various combinations by one of ordinary skill in this art to perform methods in accordance with the principles described herein. Among the various elements, features, and steps some will be specifically included and others specifically excluded in diverse

embodiments.

[00135] Although the application has been disclosed in the context of certain

embodiments and examples, it will be understood by those skilled in the art that the

embodiments of the application extend beyond the specifically disclosed embodiments to other alternative embodiments and/or uses and modifications and equivalents thereof.

[00136] In some embodiments, the terms "a" and "an" and "the" and similar references used in the context of describing a particular embodiment of the application (especially in the context of certain of the following claims) can be construed to cover both the singular and the plural. The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (for example, "such as") provided with respect to certain embodiments herein is intended merely to better illuminate the application and does not pose a limitation on the scope of the application otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the application.

[00137] Other than in the operating examples, or where otherwise indicated, all numbers expressing quantities of ingredients or reaction conditions used herein should be understood as modified in all instances by the term "about." The term "about" when used in connection with percentages can mean ±1%.

[00138] As used herein the term "comprising" or "comprises" is used in reference to compositions, methods, and respective component(s) thereof, that are essential to the invention, yet open to the inclusion of unspecified elements, whether essential or not.

[00139] As used herein the term "consisting essentially of or "consists essentially of refers to those elements required for a given embodiment. The term permits the presence of additional elements that do not materially affect the basic and novel or functional

characteristic(s) of that embodiment of the invention.

[00140] The term "consisting of refers to compositions, methods, and respective components thereof as described herein, which are exclusive of any element not recited in that description of the embodiment.

[00141] Preferred embodiments of this application are described herein, including the best mode known to the inventors for carrying out the application. Variations on those preferred embodiments will become apparent to those of ordinary skill in the art upon reading the foregoing description. It is contemplated that skilled artisans can employ such variations as appropriate, and the application can be practiced otherwise than specifically described herein. Accordingly, many embodiments of this application include all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law.

Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the application unless otherwise indicated herein or otherwise clearly contradicted by context.

[00142] All patents, patent applications, publications of patent applications, and other material, such as articles, books, specifications, publications, documents, things, and/or the like, referenced herein are hereby incorporated herein by this reference in their entirety for all purposes, excepting any prosecution file history associated with same, any of same that is inconsistent with or in conflict with the present document, or any of same that may have a limiting affect as to the broadest scope of the claims now or later associated with the present document. By way of example, should there be any inconsistency or conflict between the description, definition, and/or the use of a term associated with any of the incorporated material and that associated with the present document, the description, definition, and/or the use of the term in the present document shall prevail.

[00143] SEQUENCES

[00144] SEQ ID NO: 1 rQNestin34.5v.2Sequence, consensus

sequence BreakPoint l 51409

[00145] AT AAC T T C GT AT AAT GT AT G C TAT AC GAAGT TAT T AG GT C C C T C GAC C T G CAG GAAAC T C T AGT C C

GGACCCGGGAGGCCTCCTTTGAGGAGTGGCTGCGATCCAAGGAAGTGGCCCTGGACT TTGGCCTGACGGAAAGGCTTC GCGAGCACGAAGCCCAGCTGGTGATCCTGGCCCAGGCTCTGGACCATTACGACTGTCTGA TCCACAGCACACCGCACA CGCTGGTCGAGCGGGGGCTGCAATCGGCCCTGAAGTATGAGGAGTTTTACCTAAAGCGCT TTGGCGGGCACTACATGG AGTCCGTCTTCCAGATGTACACCCGCATCGCCGGCTTTTTGGCCTGCCGGGCCACGCGCG GCATGCGCCACATCGCCC TGGGGCGAGAGGGGTCGTGGTGGGAAATGTTCAAGTTCTTTTTCCACCGCCTCTACGACC ACCAGATCGTACCGTCGA CCCCCGCCATGCTGAACCTGGGGACCCGCAACTACTACACCTCCAGCTGCTACCTGGTAA ACCCCCAGGCCACCACAA ACAAGGCGACCCTGCGGGCCATCACCAGCAACGTCAGTGCCATCCTCGCCCGCAACGGGG GCATCGGGCTATGCGTGC AGGCGTTTAACGACTCCGGCCCCGGGACCGCCAGCGTCATGCCCGCCCTCAAGGTCCTCG ACTCGCTGGTGGCGGCGC ACAACAAAGAGAGCGCGCGTCCGACCGGCGCGTGCGTGTACCTGGAGCCGTGGCACACCG ACGTGCGGGCCGTGCTCC GGATGAAGGGGGTCCTCGCCGGCGAAGAGGCCCAGCGCTGCGACAATATCTTCAGCGCCC TCTGGATGCCAGACCTGT TTTTCAAGCGCCTGATTCGCCACCTGGACGGCGAGAAGAACGTCACATGGACCCTGTTCG ACCGGGACACCAGCATGT CGCTCGCCGACTTTCACGGGGAGGAGTTCGAGAAGCTCTACCAGCACCTCGAGGTCATGG GGTTCGGCGAGCAGATAC CCATCCAGGAGCTGGCCTATGGCATTGTGCGCAGTGCGGCCACGACCGGGAGCCCCTTCG TCATGTTCAAAGACGCGG TGAACCGCCACTACATCTACGACACCCAGGGGGCGGCCATCGCCGGCTCCAACCTCTGCA CCGAGATCGTCCATCCGG CCTCCAAGCGATCCAGTGGGGTCTGCAATCTGGGAAGCGTGAATCTGGCCCGATGCGTCT CCAGGCAGACGTTTGACT TTGGGCGGCTCCGCGACGCCGTGCAGGCGTGCGTGCTGATGGTGAACATCATGATCGACA GCACGCTACAACCCACGC CCCAGTGCACCCGCGGCAACGACAACCTGCGGTCCATGGGAATCGGCATGCAGGGCCTGC ACACGGCCTGCCTGAAGC TGGGGCTGGATCTGGAGTCTGCCGAATTTCAGGACCTGAACAAACACATCGCCGAGGTGA TGCTGCTGTCGGCGATGA AGACCAGCAACGCGCTGTGCGTTCGCGGGGCCCGTCCCTTCAACCACTTTAAGCGCAGCA TGTATCGCGCCGGCCGCT TTCACTGGGAGCGCTTTCCGGACGCCCGGCCGCGGTACGAGGGCGAGTGGGAGATGCTAC GCCAGAGCATGATGAAAC ACGGCCTGCGCAACAGCCAGTTTGTCGCGCTGATGCCCACCGCCGCCTCGGCGCAGATCT CGGACGTCAGCGAGGGCT TTGCCCCCCTGTTCACCAACCTGTTTAGCAAGGTGACCCGGGACGGCGAGACGCTGCGCC CCAACACGCTCCTGCTAA AGGAACTGGAACGCACGTTTAGCGGGAAGCGCCTCCTGGAGGTGATGGACAGTCTCGACG CCAAGCAGTGGTCCGTGG CGCAGGCGCTCCCGTGCCTGGAGCCCACCCACCCCCTCCGGCGATTCAAGACCGCGTTTG ACTACGACCAGAAGTTGC TGATCGACCTGTGTGCGGACCGCGCCCCCTACGTCGACCATAGCCAATCCATGACCCTGT ATGTCACGGAGAAGGCGG ACGGGACCCTCCCAGCCTCCACCCTGGTCCGCCTTCTGGTCCACGCATATAAGCGCGGAC TAAAAACAGGGATGTACT ACTGCAAGGTTCGCAAGGCGACCAACAGCGGGGTCTTTGGCGGCGACGACAACATTGTCT GCACGAGCTGCGCGCTGT GACCGACAAACCCCCTCCGCGCCAGGCCCGCCGCCACTGTCGTCGCCGTCCCACGCGCTC CCCCGCTGCCATGGATTC CGCGGCCCCAGCCCTCTCCCCCGCTCTGACGGCCCATACGGGCCAGAGCGCGCCGGCGGA CCTGGCGATCCAGATTCC AAAGTGCCCCGACCCCGAGAGGTACTTCTACACCTCCCAGTGTCCCGACATTAACCACCT GCGCTCCCTCAGCATCCT TAACCGCTGGCTGGAAACCGAGCTTGTTTTCGTGGGGGACGAGGAGGACGTCTCCAAGCT TTCCGAGGGCGAGCTCAG CTTTTACCGCTTCCTCTTCGCTTTCCTGTCGGCCGCCGACGACCTGGTTACGGAAAACCT GGGCGGCCTCTCCGGCCT GTTTGAGCAGAAGGACATTCTCCACTACTACGTGGAGCAGGAATGCATCGAAGTCGTACA CTCGCGCGTGTACAACAT CATCCAGCTGGTGCTTTTTCACAACAACGACCAGGCGCGCCGCGAGTACGTGGCCGGCAC CATCAACCACCCGGCCAT CCGCGCCAAGGTGGACTGGTTGGAAGCGCGGGTGCGGGAATGCGCCTCCGTTCCGGAAAA GTTCATTCTCATGATCCT CATCGAGGGCATCTTTTTTGCCGCCTCGTTTGCCGCCATCGCCTACCTTCGCACCAACAA CCTTCTGCGGGTCACCTG CCAGTCAAACGACCTCATCAGCCGGGACGAGGCCGTGCACACGACGGCCTCGTGTTACAT CTACAACAACTACCTCGG CGGGCACGCCAAGCCCCCGCCCGACCGCGTGTACGGGCTGTTCCGCCAGGCGGTCGAGAT CGAGATCGGATTTATCCG ATCCCAGGCGCCGACGGACAGCCATATCCTGAGCCCGGCGGCGCTGGCGGCCATCGAAAA CTACGTGCGATTCAGCGC GGATCGCCTGTTGGGCCTTATCCACATGAAGCCACTGTTTTCCGCCCCACCCCCCGACGC CAGCTTTCCGCTGAGCCT CATGTCCACCGACAAACACACCAATTTTTTCGAGTGTCGCAGCACCTCCTACGCCGGGGC GGTCGTCAACGATCTGTG AGGGTCGCGGCGCGCTTCTACCCGTGTTTGCCCATAATAAACCTCTGAACCAAACTTTGG GTCTCATTGTGATTCTTG TCAGGGACGCGGGGGTGGGAGAGGATAAAAGGCGGCGCAAAAAGCAGTAACCAGGTCCGG CCAGATTCTGAGGGCATA GGATACCATAATTTTATTGGTGGGTCGTTTGTTCGGGGACAAGCGCGCTCGTCTGACGTT TGGGCTACTCGTCCCAGA ATTTGGCCAGGACGTCCTTGTAGAACGCGGGTGGGGGGGCCTGGGTCCGCAGCTGCTCCA GAAACCTGTCGGCGATAT CAGGGGCCGTGATATGCCGGGTCACGATAGATCGCGCCAGGTTTTCGTCGCGGATGTCCT GGTAGATAGGCAGGCGTT TCAGAAGAGTCCACGGCCCCCGCTCCTTGGGGCCGATAAGCGATATGACGTACTTAATGT AGCGGTGTTCCACCAGCT CGGTGATGGTCATGGGATCGGGGAGCCAGTCCAGGGACTCTGGGGCGTCGTGGATGACGT GGCGTCGCCGGCTGGCCA CATAACTGCGGTGCTCTTCCAGCAGCTGCGCGTTCGGGACCTGGACGAGCTCGGGCGGGG TGAGTATCTCCGAGGAGG ACGACCTGGGGCCGGGGTGGCCCCCGGTAACGTCCCGGGGATCCAGGGGGAGGTCCTCGT CGTCTTCGTATCCGCCGG CGATCTGTTGGGTTAGAATTTCGGTCCACGAGACGCGCGTCTCGGTGCCGCCGGTGGCCG GCGGCAGAGGGGGCCTGG TTTCCGTGGAGCGCGAGCTGGTGTGTTCCCGGCGGATGGCCCGCCGGGTCTGAGAGCGAC TCGGGGGGGTCCAGTGAC ATTCGCGCAGCACATCCTCCACGGAGGCGTAGGTGTTATTGGGATGGAGGTCGGTGTGGC AGCGGACAAAGAGGGCCA GGAACTGGGGGTAGCTCATCTTAAAGTACTTCAGTATATCGCGACAGTTGATCGTGGGAA TGTAGCAGGCGCTAATAT CCAACACAATATCGCAGCCCATCAACAGGAGGTCAGTGTCCGTGGTGTACACGTACGCGA CCGTGTTGGTGTGATAGA GGTTGGCGCAGGCATCGTCCGCCTCCAGCTGACCCGAGTTAATGTAGGCGTACCCCAGGG CCCGGAGAACGCGAATAC AGAACAGATGCGCCAGACGCAGGGCCGGCTTCGAGGGCGCGGCGGACGGCAGCGCGGCTC CGGACCCGGCCGTCCCCC GGGTCCCCGAGGCCAGAGAGGTGCCGCGTCGGCGCATGTTGGAAAAGGCAGAGCTGGGTC TGGAGTCGGTGATGGGGG AAGGCGGTGGAGAGGCGTCCACGTCACTGGCCTCCTCGTCCGTCCGGCACTGGGCCGTCG TGCGGGCCAGGATGGCCT TGGCTCCAAACACAACCGGCTCCATACAATTGACCCCGCGATCGGTAACGAAGATGGGGA AAAGGGACTTTTGGGTAA ACACTTTTAATAAGCGACAGAGGCAGTGTAGCGTAATGGCCTCGCGGTCGTAACTGGGGT ATCGGCGCTGATATTTGA CCACCAACGTGTACATGACGTTCCACAGGTCCACGGCAATGGGGGTGAAGTACCCGGCCG GGGCCCCAAGGCCCCGGC GCTTGACCAGATGGTGTGTGTGGGCAAACTTCATCATCCCGAACAAACCCATGTCAGGTC GATTGTAACTGCGGATCG GCCTAACTAAGGCGTGGTTGGTGCGACGGTCCGGGACACCCGAGCCTGTCTCTCTGTGTA TGGTGACCCAGACAACAA CACCGACACAAGAGGACAATAATCCGTTAGGGGACGCTCTTTATAATTTCGATGGCCCAA CTCCACGCGGATTGGTGC AGCACCCTGCATGCGCCGGTGCGGGCCAACCTTCCCCCCGCTCATTGCCTCTTCCAAAAG GGTGTGGCCTAACGAGCT GGGGGCGTATTTAATCAGGCTAGCGCGGCGGGCCTGCCGTAGTTTCTGGCTCGGTGAGCG ACGGTCCGGTTGCTTGGG TCCCCTGGCTGCCATCAAAACCCCACCCTCGCAGCGGCATACGCCCCCTCCGCGTCCCGC ACCCGAGACCCCGGCCCG GCTGCCCTCACCACCGAAGCCCACCTCGTCACTGTGGGGTGTTCCCAGCCCGCGTTGGGA TGACGGATTCCCCTGGCG GTGTGGCCCCCGCCTCCCACGTGGAGGACGCGTCGGACGCGTCCCTCGGGCAGCCGGAGG AGGGGGCGCCCTGCCAGG TGGTCCTGCAGGGCGCCGAGCTTAATGGAATCCTACAGGCGTTTGCCCCGCTGCGCACGA GCCTTCTGGACTCGCTTC TGGTTATGGGAGACCGGGGCATCCTTATCCATAACACGATCTTTGGGGAGCAGGTGTTCC TGTCCCTGGAACACTCGC AATTCAGTCGGTATCGCTGGCGCGGACCCACGGCGGCGTTCCTGTCTCTCGTGGACCAGA AGCGCTCCCTCCTGAGCG TGTTTCGCGCCAACCAGTACCCGGACCTACGTCGGGTGGAGTTGGCGATCACGGGCCAGG CCCCGTTTCGCACGCTGG TTCAGCGCATATGGACGACGACGTCCGACGGCGAGGCCGTTGAGCTAGCCAGCGAGACGC TGATGAAGCGCGAACTGA CGAGCTTTGTGGTGCTGGTTCCCCAGGGAACCCCCGACGTTCAGTTGCGCCTGACGAGGC CGCAGCTCACCAAGGTCC TTAACGCGACCGGGGCCGATAGTGCCACGCCCACCATGTTCGAGCTCGGGGTTAACGGCA AATTTTCCGTGTTCACCA CGAGTACCTGCGTCACATTTGCTGCCCGCGAGGAGGGCGTGTCGTCCAGCACCAGCACCC AGGTCCAGATCCTGTCCA ACGCGCTCACCAAGGCGGGCCAGGCGGCCGCCAACGCCAAGACGGTGTACGGGGAAAATA CCCATCGTACCTTCTCTG TGGTCGTCGACGATTGCAGCATGCGGGCGGTGCTCCGGCGACTGCAGGTCGCCGGGGGCA CCCTCAAGTTCTTCCTCA CGACCCCCGTCCCCAGTCTGTGCGTCACCGCCACCGGTCCCAACGCGGTATCGGCGGTAT TTCTCCTGAAACCCCAGA AGATTTGCCTGGACTGGCTGGGTCATAGCCAGGGGTCTCCTTCCGCCGGGAGCTCGGCCT CCCGGGCCTCTGGGAGCG AGCCAACAGACAGCCAGGACTCCGCGTCGGACGCGGTCAGCCACGGCGATCCGGAAGACC TCGATGGCGCTGCCCGGG CGGGAGAGGCGGGGGCCTCGTACGCCTGTCCGATGCCGTCGTCGACCACGCGGGTCACTC CCACGACCAAGCGGGGGC GCTCGGGGGGCGAGGATGCGCACGCGGACACGGCCCTAAAGAAACCTAAGACGGGGTCGC CCACCGCACCCCCGCCCG CAGATCCAGTCCCCCTGGACACGGAGGACGACTCCGATGCGGCGGACGGGACAGCGGCCC GTCCCGCCGCTCCAGACG CCCGAAGCGGAAGCCGTTACGCGTGTTACTTTCGCGACCTCCCGACCGGAGAAGCAAACC CCGGCGCCTTCTCCGCCT TCCGGGGGGGCCCCCAAACCCCGTCTGGTTTTGGATTCCCCTGACGGGGCGGGGCCTTAG CGGCCGCCCAACCCTCGC AACATCCCGGGGTTAATGTAAATAAACTTGGTATTGCCCAACACTCTCCCGCGTGTCGCG TGTGGTTCATGTGTGTGC CTGGCGCCCCCACCCTCGGGTTCGTGTATTTCCTTTCCCTGTCCTTATAAAAGCCGTATG TGGGGCGCTGACGGAACC ACCCCGCGTGCCATCACGGCCAAGGCGCGGGATGCTCCGCAACGACAGCCACCGGGCCGC GTCCCCGGAGGACGGCCA GGGACGGGTCGACGACGGACGGCCACACCTCGCGTGCGTGGGGGCCCTGGCGCGGGGGTT CATGCATATCTGGCTTCA GGCCGCCACGCTGGGTTTTGCGGGATCGGTCGTTATGTCGCGCGGGCCGTACGCGAATGC CGCGTCTGGGGCGTTCGC CGTCGGGTGCGCCGTGTTGGGCTTTATGCGCGCGCCCCCTCCCCTCGCGCGGCCCACCGC GCGGATATACGCCTGGCT CAAACTGGCGGCCGGTGGAGCGGCCCTTGTTCTGTGGAGTCTCGGGGAGCCCGGCACGCA GCCGGGGGCCCTGGCCCC GGGCCCGGCCACCCAGTGCCTGGCGCTGGGCGCCGCCTATGCGGCGCTCCTGGTGCTCGC CGATGACGTCTATCCGCT CTTTCTCCTCGCCCCGGGGCCCCTGTTCGTCGGCACCCTGGGGATGGTCGTCGGCGGGCT GACGATCGGAGGCAGCGC GCGCTACTGGTGGATCGGTGGGCCCGCCGCGGCCGCCCTGGCCGCGGCGGTGTTGGCGGG CCCGGGGGCGACCACCGC CAGGGACTGCTTCTCCAGGGCGTGCCCCGACCACCGCCGCGTCTGCGTCATCGTCGCAGG CGAGTCTGTTTCCCGCCG CCCCCCGGAGGACCCAGAGCGACCCGGGGACCCAGGGCCACCGTCCCCCCCGACACCCCA ACGATCCCAGGGGCCGCC GGCCGATGAGGTCGCACCGGCCGGGGTAGCGCGGCCCGAAAACGTCTGGGTGCCCGTGGT CACCTTTCTGGGGGCTGG CGCGCTCGCCGTCAAGACGGTGCGAGAACATGCCCGGGGAACGCCGGGCCCGGGCCTGCC GCTGTGGCCCCAGGTGTT TCTCGGAGGCCATGTGGCGGTGGCCCTGACGGAGCTGTGTCAGGCGCTTGCGCCCTGGGA CCTTACGGACCCGCTGCT GTTTGTTCACGCCGGACTGCAGGTCATCAACCTCGGGTTGGTGTTTCGGTTTTCCGAGGT TGTCGTGTATGCGGCGCT AGGGGGTGCCGTGTGGATTTCGTTGGCGCAGGTGCTGGGGCTCCGGCGTCGCCTGCACAG GAAGGACCCCGGGGACGG GGCCCGGTTGGCGGCGACGCTTCGGGGCCTCTTCTTCTCCGTGTACGCGCTGGGGTTTGG GGTGGGGGCGCTGCTGTG CCCTCCGGGGTCAACGGGCGGGCGGTCGGGCGATTGATATATTTTTCAATAAAAGGCATT AGTCCCGAAGACCGCCGG TGTGTGATGATTTCGCCATAACACCCAAACCCCGGATGGGGCCCGGGTATAAATTCCGGA AGGGGACACGGGCTACCT TCACTACCGAGGGCGCTTGGTCGGGAGGCCGCATCGAACGCACACCCCCATCCGGTGGTC CGTGTGGAGGTCGTTTTT CATTGCCCGGTCTCGCTTTGCCGGGAACGCTAGCCGATCCCTCGCGAGGGGGAGGCGTCG GGCATGGCCCCGGGGCGG GTGGGCCTTGCCGTGGTCCTGTGGAGCCTGGTGTGGCTCGGGGCGGGGGTGTCCGGGGGC TCGGAAACTGCCTCCACC GGGCCCACGATCACCGCGGGAGCGGTGACGAACGCGAGCGAGGCCCCCACATCGGGGTCC CCCGGGTCAGCCGCCAGC CCGGAGGTCACCCCCACATCGACCCCAAACCCCAACAATGTCACACAAAACCAAACCACC CCCACCGAGCCGGCCAGC CCCCCAACAACCCCCAAGCCCACCTCCACACCCAAAAGCCCCCCCACGTCCACCCCCGAC CCCAAACCCAAGAACAAC ACCACCCCCGCCAAGTCGGACCGCCCCACTAAACCCCCCGGGCCCGTGTGGTGCGACCGC CGCGATTTATTGGCCCGG TACGGCTCGCGGGTGCAGATCCGATGCCGGTTTCGGAATTCCACCCGCATGGAGTTCCGC CTCCAGATATGGCGTTAC TCCATGGGTCCGTCCCCCCCAATCGCTCCGGCTCCCGACCTAGAGGAGGTCCTGACGAAC ATCACCGCCCCACCCGGG GGACTCCTGGTGTACGACAGCGCCCCCAACCTAACGGACCCCCACGTGCTCTGGGCGGAG GGGGCCGGCCCGGGCGCC GACCCTCCGTTGTATTCTGTCACCGGGCCGCTGCCGACCCAGCGGCTGATTATCGGCGAG GTGACGCCCGCGACCCAG GGAATGTATTACTTGGCCTGGGGCCGGATGGACAGCCCGCACGAGTACGGGACGTGGGTG CGCGTCCGCATGTTCCGC CCCCCGTCTCTGACCCTCCAGCCCCACGCGGTGATGGAGGGTCAGCCGTTCAAGGCGACG TGCACGGCCGCCGCCTAC TACCCGCGTAACCCCGTGGAGTTTGTCTGGTTCGAGGACGACCACCAGGTGTTTAACCCG GGCCAGATCGACACGCAG ACGCACGAGCACCCCGACGGGTTCACCACAGTCTCTACCGTGACCTCCGAGGCTGTCGGC GGCCAGGTCCCCCCGCGG ACCTTCACCTGCCAGATGACGTGGCACCGCGACTCCGTGACGTTCTCGCGACGCAATGCC ACCGGGCTGGCCCTGGTG CTGCCGCGGCCAACCATCACCATGGAATTTGGGGTCCGGCATGTGGTCTGCACGGCCGGC TGCGTCCCCGAGGGCGTG ACGTTTGCCTGGTTCCTGGGGGACGACCCCTCACCGGCGGCTAAGTCGGCCGTTACGGCC CAGGAGTCGTGCGACCGC CCCGGGCTGGCTACGGTCCGGTCCACCCTGCCCATTTCGTACGACTACAGCGAGTACATC TGTCGGTTGACCGGATAT CCGGCCGGGATTCCCGTTCTAGAGCACCACGGCAGTCACCAGCCCCCACCCAGGGACCCC ACCGAGCGGCAGGTGATC GAGGCGATCGAGTGGGTGGGGATTGGAATCGGGGTTCTCGCGGCGGGGGTCCTGGTCGTA ACGGCAATCGTGTACGTC GTCCGCACATCACAGTCGCGGCAGCGTCATCGGCGGTAACGCGAGACCCCCCCGTTACCT TTTTAATATCTATATAGT TTGGTCCCCCTCTATCCCGCCCACCGCTGGGCGCTATAAAGCCGCCACCCTCTCTTCCCT CAGGTCATCCTTGGTCGA TCCCGAACGACACACGGCGTGGAGCAAAACGCCTCCCCCTGAGCCGCTTTCCTACCAGCG CAACGGCATGCCTCTGCG GGCATCGGAACACGCCTACCGGCCCCTGGGCCCCGGGACACCCCCCATGCGGGCTCGGCT CCCCGCCGCGGCCTGGGT TGGCGTCGGGACCATCATCGGGGGAGTTGTGATCATTGCCGCGTTGGTCCTCGTGCCCTC GCGGGCCTCGTGGGCACT TTCCCCATGCGACAGCGGATGGCACGAGTTCAACCTCGGGTGCATATCCTGGGATCCGAC CCCCATGGAGCACGAGCA GGCGGTCGGCGGCTGTAGCGCCCCGGCGACCCTGATCCCCCGCGCGGCTGCCAAACAGCT GGCCGCCGTCGCACGCGT CCAGTCGGCAAGATCCTCGGGCTACTGGTGGGTGAGCGGAGACGGCATTCGGGCCTGCCT GCGGCTCGTCGACGGCGT CGGCGGTATTGACCAGTTTTGCGAGGAGCCCGCCCTTCGCATATGCTACTATCCCCGCAG TCCCGGGGGCTTTGTTCA GTTTGTAACTTCGACCCGCAACGCGCTGGGGCTGCCGTGAGGCGCGTGTACTGCGGTCTG TCTCGTCTCCTCTTCTCC CCTTCCCTCCCCCTCCGCATCCCAGGATCACACCGGCCAACGAGGGTTGGGGGGTCCGGC ACGGACCCAAAATAATAA ACACACAATCACGTGCGATAAAAAGAACACGCGGTCCCCTGTGGTGTTTTTGGTTATTTT TATTAAATCTCGTCGTCA AACAGGGGGAAAGGGGCGTGGTCTAGCGACGGCAGCACGGGTGGAGGCGTTCACCGGCTC CGGCGTCCTTCGCGTTTA AGCTTGGTCAGGAGGGCGCTCAGGGCGGCGACGTTGGTCGGGCCGTCGTTGGTCAGGGCG TTGGCTCGATGGCGGGCG AGGACGGGCGAGGGGCTCAACGGCGGGGGCGGGGGCCCGGTGCGGCCCGGGGGGGAAAAT AGGGCGGATCCCCCCCAG TCGTACAGGGGATTTTCCGCCTCAATGTACGGGGAGGCCGGCGCTGCATTCGCCGTGTTC GCGCAGACGTTTTCGTAG ACCCGCATCCATGGTATTTCCTCGTAGACACGCCCCCCGTCCTCGCTCACAGTCTCGTAT ATTGACTCGTCGTCCTCG TAGGGGGCGTGCCGTTCGCGGGCCGAGGCGGCGTGGGTGGCTTTGCGGCGGGCGTCGTCG TCGTCGTCGTCGGCCGTC AGATACGTGGCTTCCATCTGGTCGGGTTCTCCCTCCGGGGCGGGTCCCCACCCCCGTGGC CGATCGAGGCTCCCCAGA GACGCGCGCCGGACGAGGAGGGGGCACGTCGCCGCCGGCGGTCGCCTGTCGGGTCCCGCG ACGTTACGGGCCGGGAGG CGCGGGGGCACCTCCCCCATGTGCGTGTAATACGTGGCCGGCTGTGCGGCCGCAGCGGGG GGCTCGGCGACCGGGTCG TCCGCATCCGGAAGCGGGGGCGCCGCGCCGTCCGCGCGGCGCCTCCGGAACCGCCGGGTG GCCGCGGGGGTCGAGTGT AGGCGAGGTCGGGGGAGGGGCGGGGGCTCGTTGTCGCGCCGCGCCCGCTGAATCTTTTCC CGACAGGTCCCACCCCCC GCGCGATGCCCCCCCGGGCCGCGGGCCATGTCGTCCGGGGGAGGCCCCGCGGACCACGTC GTCCGGCGAGACGCCACG AGCCGCAGGATGGACTCGTAGTGGAACGACGGCGCCCCGCTGCGGAGCAGATCCGCGGCC AGGGCGGCCCCGAACCAA GCCTTGATGCTCAACTCCATCCGGGCCCAGCTGGGGGCGGTCATCGTGGGGAACAGGGGG GCGGTGGTCCGACAGAAA CGCTCCTGGCTGTCCACCGCGGCCCGCAGATACTCGTTGTTCAGGCTGTCGGTGGCCCAG ACGCCGTACCCGGTGAGG GTCGCGTTGATGATATACTGGGCGTGGTGATGGACGATCGACAGAACCTCCACCGTGGAT ACGACGGTATCCACGGTC CCGTACGTACCGCCGCTCCGCTTGCCGGTCTGCCACAGGTTGGCTAGGCGCGTCAGGTGG CCCAGGACGTCGCTGACC GCCGCCCTGAGCGCCATGCACTGCATGGAGCCGGTCGTGCCGCTGGGACCCCGGTCCAGA TGGCGCGCGAACGTTTCC GCGGGCGCCTCCGGGCTGCCGCCGAGCGGGAGGAACCGGCGATTGGAGGGACTCAGCCGG TGGCATACGTGCTTGTCT GTCGTCCACAGCATCCAGGACGCCCACCGGTACAGCACGGAGACGTAGGCCAGGAGCTCG TTGAGCCGCAGTGCGGTG TCGGTGCTGGGGCGGCTTGGGTCCGCCGGGCGCATAAAGAACATGTACTGCTGAATCCGA TGGAGGGCGTCGCGCAGG CCGGCCACGGTGGCGGCGTACTTGGCCGCCGCGGCCCCGCTCTTGAACGGGGTGCGCGCC AGCAGCTTTGGCGCCAGG GTGGGCCGCAGCAGCACGTGAAGGCTGGGGTCGCAGTCGCCCACGGGGTCCTCGGGGACG TCCAGGCCGCTGGGCACC ACCGTCTGCAGGTACTTCCAGTACTGCGTGAGGATGGCGCGGCTCAACTGGCCGCCGGTG AGCTCCACCTCGCCCAGC GCCTGGGTGGCGGCCGAAGCGTAGTGCCGGATGTACTCGTAGTGCGGGTCGCTGGCGAGC CCGTCCACGATCAAACTC TCGGGAACCGTGTTGTGTTGCCGCGCGGCCAACCGGACGCTGCGATCGGTGCAGGTCAGA AACGCCGGCTGCGCGTCG TCGGAGCGCTGCCGCAAGGCGCCCACGGCCGCGCTAAGGAGCCCCTCCGGGGTGGGGAGC AGACACCCGCCGAAGATG CGCCGCTCGGGAACGCCCGCGTTGTCGCCGCGGATCAGGTTGGCAGGCGTCAGGCACCGC GCCAGCCGCAGGGAGCTC GCGCCGCGCGTCCGGCGCTGCATGGTGACGCCCGTTCGGTCGGGACCCGCCGGTCGGAGT TATGCCGCGTCCAGGGCC ATCGGGGCGCTTTTTATCGGGAGGAGCTTATGGGCGTGGCGGGCCTCCCAGCCCGGTCGC GCGCCTCCCCGACACGTG CGCCCGCAGGGCGGCGGCCCCCTCGTCTCCCATCAGCAGTTTCCTAAACTGGGACATGAT GTCCACCACGCGGACCCG CGGGCCCAACACGGACCCGCCGCTTACGGGGGCGGGGGGGAAGGGCTCCAGGTCCTTGAG AAGAAAGGCGGGGTCTGC CGTCCCGGACACGGGGGCCCGGGGCGCTGAGGAGGCGGGGCGCAGATCCACGTGCTCCGC GGCCGCGCGGACGTCCGC CCAGAACTTGGCGGGGGTGGTGCGCGCGTACAGGGGCTGGGTCGCTCGGAGGACGCACGC GTAGCGCAGGGGGGTGTA TGTGCCCACCTCGGGGGCCGTGAATCCCCCGTCAAACGCGGCCAGTGTCACGCACGCCAC CACGGTGTCGGCAAAGCC CAGCAGCCGCTGCAGGACGAGCCCGGCGGCCAGAATGGCGCGCGTGGCCGCCGCGTCGTC CCGGCGCCGGTGCGCGTC CCCGCACGCCCGGGCGTACTTTAAGGTCACGGTCGCCAGGGCCGTGTGCAGCGCGTACAC CGCAGCGCCCAGCACGGC GTTGAGCCCGCTGTTGGCGAGCAGCCGGCGCGCTGCGGTGTCGCCCAGCGCCTCGTGCTC GGCCCCCACGACCGCGGG GCTTCCCAGGGGCAGGGCGCGAAACAGCTCCTCCCGCGCCACGTCCGCAAAGGCGGGGTG GTGCACGTGCGGGTGCAG GCGCGCCCCCACGACCACCGAGAGCCACTGGACCGTCTGCTCCGCCATCACCGCCAGCAC ATCCAGCACGCGCCCCAG GAAGGCGGCCTCCCGCGTCAAAACGCACCGGACGGCGTCGGGATTGAAGCGGGCGAGCAG GGCCCCGGTGGCCAGGTA CGTCATGCGGCCGGCATAGCGGGCGGCCACGCGACAGTCGCGGTCCAGCAGCGCGCGCAC CCCGGGCCAGTACAGCAG GGACCCCAGCGAGCTGCGAAACACCGCGGCGTCGGGGCCGGATTGGGGGGACACTAACCC CCCCGCGCTCAGTAACGG CACGGCCGCGGCCCCGACGGGACGCAACGCCGTGAGGCTCGCGAACTGCCGCCTCAGCTC GGCAGCCCTGTCGTCCAG GTCCGACCCGCGCGCCTCTGCGTGAAGGCGCGTCCCGCACACCCACCCGTTGATGGCCAG CCGCACGACGGCATCCGC CAAAAAGCTCATCGCCTGGGCGGGGCTGGTTTTTGTTCGACGATCCATCAGGTCAAGAAT CCCATCGCCCGTGATATA CCAGGCCAACGCCTCGCCCTGCTGCAGGGTTTGGCGGAAAAACACCGCGGGGTTGTCGGG GGAGGCGAAGTGCATGAC CCCCACGCGCGATAACCCGAACGCGCTATCCGGACACGGGTAAAACCCGGCCGGATGCCC CAGGGCTAGGGCGGAGCG CACGGACTCGTCCCACACGGCAACCTGAGGGGCCAGTCGATCCAACGGGAATGCCGCCAG GAGCTCCGGGCCCGGCAC GCGTCCCTCCAGAACCTCCACCTTGGGCGGGGAACGGGCCCCGCCGCCGTCCTCCGGCCC GACGTCTTCCGGGTAGTC GTCCTCCTCGTACTGCAGCTCCTCTAGGAACAGCGGCGACGGCGCCACCCGCGAACCGCC GACCCGCCCCAAAATAGC CCGCGCGTCGACGGGACCCAGGTATCCCCCCTGCCGGGCCTGCGGAGGACCGCGGGGAAC CTCATCATCATCGTCCAG GCGACCGCGCACCGACTGGCTACGGGCCGCATCGGGCCCGGGGCGCTGCCGGGACGCTCG GCGATGGGATGTGGGCGG GGCTTCCGACGCGCGCCGTCGTCGGGCTCGCGGGCCTTCCCGTCGACGGCGCACGGGCGG CTCGTCGCCCGCCATCTC CTCCAGAGCCTCTAGCTCGCTGTCGTCATCCCCGCGGAACACCGCACGCAGGTACCCCAT GAACCCCACCCCATCGCC CGCTGGCTCGTCCGCCACGGGCGAGGCGCGGGGGCGGGTGGATGCGCGCCTCCTACGCCC CGCGGGTTCGCGAGCCGA CATGGTGGCGATAGACGCGGGTTATCGGATGTCCGCTACCCCCCAAAAAAGAAAAAGACC CCACAGCGCGGATGGAGG CCGGGGTAGGTGCCGCCGGACCCCCTCGCGATGGGAATGGACGGGAGCGACGGGGCCGGC GCAAAAAACGCAGTATCT CCCGCGAAGGCTACCCGCCGCCCCAGCCCCCGGCCAAATGCGGAAACGGTCCCGCGCTCT CGCCTTTATACGCGGGCC GCCCTGCGACACAATCACCCGTCCGTGGTTTCGAATCTACACGACAGGCCCGCAGACGCG GCTAACACACACGCCGGC AACCCAGACCCCAGTGGGTTGGTTGCGCGGTCCCGTCTCCTGGCTAGTTCTTTTCCCCAC CACCAAATAATCAGACGA CAACCGCAGGTTTTTGTAATGTATGTGCTCGTGTTTATTGTGGATACGAACCGGGGACGG GAGGGGAAAACCCAGACG GGGGATGCGGGTCCGGTCGCGCCCCCTACCCACCGTACTCGTCAATTCCAAGGGCATCGG TAAACATCTGCTCAAACT CGAAGTCGGCCATATCCAGAGCGCCGTAGGGGGCGGAGTCGTGGGGGGTAAATCCCGGAC CCGGGGAATCCCCGTCCC CCAACATGTCCAGATCGAAATCGTCTAGCGCGTCGGCATGCGCCATCGCCACGTCCTCGC CGTCTAAGTGGAGCTCGT CCCCCAGGCTGACATCGGTCGGGGGGGCCGTCGACAGTCTGCGCGTGTGTCCCGCGGGGA GAAAGGACAGGCGCGGAG CCGCCAGCCCCGCCTCTTCGGGGGCGTCGTCGTCCGGGAGATCGAGCAGGCCCTCGATGG TAGACCCGTAATTGTTTT TCGTACGCGCGCGGCTGTACGCGTGTTCCCGCATGACCGCCTCGGAGGGCGAGGTCGTGA AGCTGGAATACGAGTCCA ACTTCGCCCGAATCAACACCATAAAGTACCCAGAGGCGCGGGCCTGGTTGCCATGCAGGG TGGGAGGGGTCGTCAACG GCGCCCCTGGCTCCTCCGTAGCCGCGCTGCGCACCAGCGGGAGGTTAAGGTGCTCGCGAA TGTGGTTTAGCTCCCGCA GCCGGCGGGCCTCGATTGGCACTCCCCGGACGGTGAGCGCTCCGTTGACGAACATGAAGG GCTGGAACAGACCCGCCA ACTGACGCCAGCTCTCCAGGTCGCAACAGAGGCAGTCAAACAGGTCGGGCCGCATCATCT GCTCGGCGTACGCGGCCC ATAGGATCTCGCGGGTCAAAAATAGATACAAATGCAAAAACAGAACACGCGCCAGACGAG CGGTCTCTCGGTAGTACC TGTCCGCGATCGTGGCGCGCAGCATTTCTCCCAGGTCGCGATCGCGTCCGCGCATGTGCG CCTGGCGGTGCAGCTGCC GGACGCTGGCGCGCAGGTACCGGTACAGGGCCGAGCAGAAGTTGGCCAACACGGTTCGAT AGCTCTCCTCCCGCGCCC GTAGCTCGGCGTGGAAGAAACGAGAGAGCGCTTCGTAGTAGAGCCCGAGGCCGTCGCGGG TGGCCGGAAGCGTCGGGA AGGCCACGTCGCCGTGGGCGCGAATGTCGATTTGGGCGCGTTCGGGGACGTACGCGTCCC CCCATTCCACCACATCGC TGGGCAGCGTTGATAGGAATTTACACTCCCGGTACAGGTCGGCGTTGGTCGGTAACGCCG AAAACAAATCCTCGTTCC AGGTATCGAGCATGGTACATAGCGCGGGGCCCGCGCTAAAGCCCAAGTCGTCGAGGAGAC GGTTAAAGAGGGCGGCGG GGGGGACGGGCATGGGCGGGGAGGGCATGAGCTGGGCCTGGCTCAGGCGCCCCGTTGCGT ACAGCGGAGGGGCCGCCG GGGTGTTTTTGGGACCCCCGGCCGGGCGGGGGGGTGGTGGCGAAGCGCCGTCCGCGTCCA TGTCGGCAAACAGCTCGT CGACCAAGAGGTCCATTGGGTGGGGTTGATACGGGAAAGACGATATCGGGCTTTTGATGC GATCGTCCCCGCCCGCCC AGAGAGTGTGGGACGCCCGACGGCGCGGGAAGAGAAAAACCCCCAAACGCGTTAGAGGAC CGGACGGACCTTATGGGG GGAAGTGGGCAGCGGGAACCCCGTCCGTTCCCGAGGAATGACAGCCCGTGGTCGCCACCC CGCATTTAAGCAACCCGC ACGGGCCGCCCCGTACCTCGTGACTTCCCCCCACATTGGCTCCTGTCACGTGAAGGCGAA CCGAGGGCGGCTGTCCAA CCCACCCCCCGCCACCCAGTCACGGTCCCCGTCGGATTGGGAAACAAAGGCACGCAACGC CAACACCGAATGAACCCC TGTTGGTGCTTTATTGTCTGGGTACGGAAGTTTTTCACTCGACGGGCCGTCTGGGGCGAG AAGCGGAGCGGGCTGGGG CTCGAGGTCGCTCGGTGGGGCGCGACGCCGCAGAACGCCCTCGAGTCGCCGTGGCCGCGT CGACGTCCTGCACCACGT CTGGATTCACCAACTCGTTGGCGCGCTGAAGCAGGTTTTTGCCCTCGCAGACCGTCACGC GGATGGTGGTGATGCCAA GGAGTTCGTTGAGGTCTTCGTCTGTGCGCGGACGCGACATGTCCCAGAGCTGGACCGCCG CCATCCGGGCATGCATGG CCGCCAGGCGCCCGACCGCGGCGCAGAAGACGCGCTTGTTAAAGCCGGCCACCCGGGGGG TCCATGGCGCGTCGGGGT TTGGGGGGGCGGTGCTAAAGTGCAGCTTTCTGGCCAGCCCCTGCGCGGGTGTCTTGGATC GGGTTGGCGCCGTCGACG CGGGGGCGTCTGGGAGTGCGGCGGATTCTGGCTGGGCCGATTTCCTGCCGCGGGTGGTCT CCGCCGCCGGGGCCGCGG GGGCCTTAGTCGCCACCCGCTGGGTTCGGGGGGCCCGGGGGGCGGTGGTGGGTGTGCGTC CGGCCCCTCCGGACCCAG CGGGCGGCGGAGGCGCCCGCGCAGGCCCCGGGCCGGACAAAACCGCCCCGGAAACGGGAC GCCGCGTCCGGGGGACCT CCGGGTGTTCGTCGTCTTCGGATGACGAGCCCCCGTAGAGGGCATAATCCGACTCGTCGT ACTGGACGAAACGGACCT CGCCCCTCGGGCGCGCGCGTGTCTGTAGGGCGCCACGGCGGGAGGTGGCAGGCGGACTAT CGGGACTCGCCATACATG AAGACGGGGTGTAGTACAGATCCTCGTACTCATCGCGCGGAACCTCCCGCGGACCCGACT TCACGGAGCGGCGAGAGG TCATGGTTCCACGAACACGCTAGGGTCGGATGCGCGGACAATTAGGCCTGGGTTCGGACG GCGGGGGGTGGTGCAGGT GTGGAGAGGTCGAGCGATAGGGGCGGCCCGGGAGAGAAGAGAGGGTCCGCAAAACCCACT GGGGATGCGTGAGTGGCC CTCTGTGGGCGGTGGGGGAGAGTCTTATAGGAAGTGCATATAACCACAACCCATGGGTCT AACCAATCCCCAGGGGCC AAGAAACAGACACGCCCCAAACGGTCTCGGTTTCCGCGAAGAAGGGGAAGTCCTGGGACA CCCTCCACCCCCACCCCT CACCCCACACAGGGCGGGTTCAGGCGTGCCCGGCAGCCAGTAGCCTCTGGCAGATCTGAC AGACGTGTGCGATAATAC ACACGCCCATCGAGGCCATGCCTACATAAAAGGGCACCAGGGCCCCGGGGGCAGACATTT GGCCAGCGTTTTGGGTCT CGCACCGCGCGCCCCCGATCCCATCGCGCCCGCCCTCCTCGCCGGGCGGCTCCCCGTGCG GGCCCGCGTCTCCCGCCG CTAAGGCGACGAGCAAGACAAACAACAGGCCCGCCCGACAGACCCTTCTGGGGGGGCCCA TCGTCCCTAACAGGAAGA TGAGTCAGTGGGGATCCGGGGCGATCCTTGTCCAGCCGGACAGCTTGGGTCGGGGGTACG ATGGCGACTGGCACACGG CCGTCGCTACTCGCGGGGGCGGAGTCGTGCAACTGAACCTGGTCAACAGGCGCGCGGTGG CTTTTATGCCGAAGGTCA GCGGGGACTCCGGATGGGCCGTCGGGCGCGTCTCTCTGGACCTGCGAATGGCTATGCCGG CTGACTTTTGTGCGATTA TTCACGCCCCCGCGCTATCCAGCCCAGGGCACCACGTAATACTGGGTCTTATCGACTCGG GGTACCGCGGAACCGTTA TGGCCGTGGTCGTAGCGCCTAAAAGGACGCGGGAATTTGCCCCCGGGACCCTGCGGGTCG ACGTGACGTTCCTGGACA TCCTGGCGACCCCCCCGGCCCTCACCAAGCCGATTTCCCTGCGGCAGTTCCCGCAACTGG CGCCCCCCCCTCCAACCG GGGCCGGGATACGCGCAGATCCTTGGTTGGAGGGGGCGCTCGGGGACCCAAGCGTGACTC CGGCCCTACCGGCGCGAC GCCGAGGGCGGTCCCTCGTCTATGCCGGCGAGCTGACGCCGGTTCAGACGGAACACGGGG ACGGCGTACGAGAAGCCA TCGCCTTCCTTCCAAAACGCGAGGAGGATGCCGGTTTCGACATTGTCGTCCGTCGCCCGG TCACCGTCCCGGCAAACG GCACCACGGTCGTGCAGCCATCCCTCCGCATGCTCCACGCGGACGCCGGGCCCGCGGCCT GTTATGTGTTGGGGCGGT CGTCGCTCAACGCCCGCGGCCTCCTGGTCGTTCCTACGCGCTGGCTCCCCGGGCACGTAT GTGCGTTTGTTGTTTACA ACCTTACGGGGGTTCCTGTGACCCTCGAGGCCGGCGCCAAGGTCGCCCAGCTCCTGGTTG CGGGGGCGGACGCTCTTC CTTGGATCCCCCCGGACAACTTTCACGGGACCAAAGCGCTTCGAAACTACCCCAGGGGTG TTCCGGACTCAACCGCCG AACCCAGGAACCCGCCGCTCTTGGTGTTTACGAACGAGTTTGACGCGGAGGCCCCCCCGA GCGAGCGCGGGACCGGGG GTTTTGGCTCTACCGGTATTTAGCCCATAGCTTGGGGTTCGTTCCGGGCAATAAAAAACG TTTGTATCTCATCTTTCC TGTGTGTAGTTGTTTCTGTTGGAGGCCTGTGGGTCTATCACACCCGCCCCTCCATCCCAC AAACACAGAACACACGGG TTGGATGAAAACACGCATTTATTGACCCAAAACACACGGAGCTGCTCGAGATGGGCCAGG GCGAGGTGCGGTTGGGGA GGCTGTAGGTCTGGGAACGGACACGCGGGGACACGATTCCGGTTTGGGGTCCGGGAGGGC GTCGCCGTTTCGGGCGGC AGGCGCCAGCGTAACCTCCGGGGGCGGCGTGTGGGGGTGCCCCAAGGAGGGCGCCTCGGT CACCCCAAGCCCCCCCAA GCGGGTTCCCCCGGCAACCCCGAAGGCGGAGAGGCCAAGGGCCCGTTCGGCGATGGCCAC ATCCTCCATGACCACGTC GCTCTCGGCCATGCTCCGAATAGCCTGGGAGACGAGCACATCCGCGGACTTGTCAGCCGC CCCCACGGACATGTACAT CTGCAGGATGGTGGCCATACACGTGTCCGCCAGGCGCCGCATCTTGTCCTGATGGGCCGC CACGGCCCCGTCGATCGT GGGGGCCTCGAGCCCGGGGTGGTGGCGCGCCAGTCGTTCTAGGTTCACCATGCAGGCGTG GTACGTGCGGGCCAAGGC GCGGGCCTTCACGAGGCGTCGGGTGTCGTCCAGGGACCCCAGGGTGTCATCGAGCGTGAT GGGGGCGGGAAGTAGCGC GTTAACGACCACCAGGGCCTCCTGCAGCCGCGGCTCCGCCTCCGAGGGCGGAACGGCCGC GCGGATCATCTCATATTG TTCCTCGGGGCGCGCTCCCCAGCCACATATAGCCCCGAGAAGAGAAGCCATCGCGGGCGG GTACTGGCCCTTGGGCGC GCGGACGCAATGGGGCAGGAAGACGGGAACCGCGGGGAGAGGCGGGCGGCCGGGACTCCC GTGGAGGTGACCGCGCTT TATGCTACCGACGGGTGCGTTATTACCTCTTCGATCGCCCTCCTCACAAACTCTCTACTG GGGGCCGAGCCGGTTTAT ATATTCAGCTACGACGCATACACGCACGATGGCCGTGCCGACGGGCCCACGGAGCAAGAC AGGTTCGAAGAGAGTCGG GCGCTCTACCAAGCGTCGGGCGGGCTAAATGGCGACTCCTTCCGAGTAACCTTTTGTTTA TTGGGGACGGAAGTGGGT GGGACCCACCAGGCCCGCGGGCGAACCCGACCCATGTTCGTCTGTCGCTTCGAGCGAGCG GACGACGTCGCCGCGCTA CAGGACGCCCTGGCGCACGGGACCCCGCTACAACCGGACCACATCGCCGCCACCCTGGAC GCGGAGGCCACGTTCGCG CTGCATGCGAACATGATCCTGGCTCTCACCGTGGCCATCAACAACGCCAGCCCCCGCACC GGACGCGACGCCGCCGCG GCGCAGTATGATCAGGGCGCGTCCCTACGCTCGCTCGTGGGGCGCACGTCCCTGGGACAA CGCGGCCTTACCACGCTA TACGTCCACCACGAGGCGCGCGTGCTGGCCGCGTACCGCAGGGCGTATTATGGAAGCGCG CAGAGTCCCTTCTGGTTT CTTAGCAAATTCGGGCCGGACGAAAAAAGCCTGGTGCTCACCACTCGGTACTACCTGCTT CAGGCCCAGCGTCTGGGG GGCGCGGGGGCCACGTACGACCTGCAGGCCATCAAGGACATCTGCGCCACCTACGCGATT CCCCACGCCCCCCGCCCC GACACCGTCAGCGCCGCGTCCCTGACCTCGTTTGCCGCCATCACGCGGTTCTGTTGCACG AGCCAGTACGCCCGCGGG GCCGCGGCGGCCGGGTTTCCGCTTTACGTGGAGCGCCGTATTGCGGCCGACGTCCGCGAG ACCAGTGCGCTGGAGAAG TTCATAACCCACGATCGCAGTTGCCTGCGCGTGTCCGACCGTGAATTCATTACGTACATT TACCTGGCCCATTTTGAG TGTTTCAGCCCCCCGCGCCTAGCCACGCATCTTCGGGCCGTGACGACCCACGACCCCAAC CCCGCGGCCAACACGGAG CAGCCCTCGCCCCTGGGCAGGGAGGCCGTGGAACAATTTTTTTGCCACGTGCGCGCCCAA CTGAATATCGGGGAGTAC GTCAAACACAACGTGACCCCCCGGGAGACCGTCCTGGATGGCGATACGGCCAAGGCCTAC CTGCGCGCTCGCACGTAC GCGCCCGGGGCCCTGACGCCCGCCCCCGCGTATTGCGGGGCCGTGGACTCCGCCACCAAA ATGATGGGGCGTTTGGCG GACGCCGAAAAGCTCCTGGTCCCCCGCGGGTGGCCCGCGTTTGCGCCCGCCAGTCCCGGG GAGGATACGGCGGGCGGC ACGCCGCCCCCACAGACCTGCGGAATCGTCAAGCGCCTCCTGAGACTGGCCGCCACGGAA CAACAGGACACCACGCCC CCGGCGATCGCGGCGCTTATCCGTAATGCGGCGGTGCAGACTCCCCTGCCCGTCTACCGG ATATCCATGGTCCCCACG GGACAGGCATTTGCCGCGCTGGCCTGGGACGACTGGGCCCGCATAACGCGGGACGCTCGC CTGGCCGAAGCGGTCGTG TCCGCCGAAGCGGCGGCGCACCCCGACCACGGCGCGCTGGGCAGGCGGCTCACGGATCGC ATCCGCGCCCAGGGCCCC GTGATGCCCCCTGGCGGCCTGGATGCCGGGGGGCAGATGTACGTGAATCGCAACGAGATA TTCAACGGCGCGCTGGCA ATCACAAACATCATCCTGGATCTCGACATCGCCCTGAAGGAGCCCGTCCCCTTTCGCCGG CTCCACGAGGCCCTGGGC CACTTTAGGCGCGGGGCTCTGGCTGCGGTTCAGCTCCTGTTTCCCGCGGCCCGCGTGGAC CCCGACGCATATCCCTGT TATTTTTTCAAAAGCGCATGTCGGCCCGGCCCGGCGTCCGTGGGTTCCGGCAGCGGACTC GGCAACGACGACGACGGG GACTGGTTTCCCTGCTACGACGACGCCGGTGATGAGGAGTGGGCGGAGGACCCGGGCGCC ATGGACACATCCCACGAT CCCCCGGACGACGAGGTTGCCTACTTTGACCTGTGCCACGAAGTCGGCCCCACGGCGGAA CCTCGCGAAACGGATTCG CCCGTGTGTTCCTGCACCGACAAGATCGGACTGCGGGTGTGCATGCCCGTCCCCGCCCCG TACGTCGTCCATGGTTCT CTAACGATGCGGGGGGTGGCACGGGTCATCCAGCAGGCGGTGCTGTTGGACCGAGATTTT GTGGAGGCCATCGGGAGC TACGTAAAAAACTTCCTGTTGATCGATACGGGGGTGTACGCCCACGGCCACAGCCTGCGC TTGCCGTATTTTGCCAAA ATCGCCCCCGACGGGCCTGCGTGCGGAAGGCTGCTGCCAGTGTTTGTGATCCCCCCCGCC TGCAAAGACGTTCCGGCG TTTGTCGCCGCGCACGCCGACCCGCGGCGCTTCCATTTTCACGCCCCGCCCACCTATCTC GCTTCCCCCCGGGAGATC CGTGTCCTGCACAGCCTGGGTGGGGACTATGTGAGCTTCTTTGAAAGGAAGGCGTCCCGC AACGCGCTGGAACACTTT GGGCGACGCGAGACCCTGACGGAGGTCCTGGGTCGGTACAACGTACAGCCGGATGCGGGG GGGACCGTCGAGGGGTTC GCATCGGAACTGCTGGGGCGGATAGTCGCGTGCATCGAAACCCACTTTCCCGAACACGCC GGCGAATATCAGGCCGTA TCCGTCCGGCGGGCCGTCAGTAAGGACGACTGGGTCCTCCTACAGCTAGTCCCCGTTCGC GGTACCCTGCAGCAAAGC CTGTCGTGTCTGCGCTTTAAGCACGGCCGGGCGAGTCGCGCCACGGCGCGGACATTCGTC GCGCTGAGCGTCGGGGCC AACAACCGCCTGTGCGTGTCCTTGTGTCAGCAGTGCTTTGCCGCCAAATGCGACAGCAAC CGCCTGCACACGCTGTTT ACCATTGACGCCGGTACGCCATGCTCGCCGTCCGTTCCCTGCAGCACCTCTCAACCGTCG TCTTGATAACGGCGTACG GCCTCGTGCTCGTGTGGTACACCGTCTTCGGTGCCAGTCCGCTGCACCGATGTATTTACG CGGTACGCCCCACCGGCA CCAACAACGACACCGCCCTCGTGTGGATGAAAATGAACCAGACCCTATTGTTTCTGGGGG CCCCGACGCACCCCCCCA ACGGGGGCTGGCGCAACCACGCCCATATCTGCTACGCCAATCTTATCGCGGGTAGGGTCG TGCCCTTCCAGGTCCCAC CCGACGCCATGAATCGTCGGATCATGAACGTCCACGAGGCAGTTAACTGTCTGGAGACCC TATGGTACACACGGGTGC GTCTGGTGGTCGTAGGGTGGTTCCTGTATCTGGCGTTCGTCGCCCTCCACCAACGCCGAT GTATGTTTGGTGTCGTGA GTCCCGCCCACAAGATGGTGGCCCCGGCCACCTACCTCTTGAACTACGCAGGCCGCATCG TATCGAGCGTGTTCCTGC AGTACCCCTACACGAAAATTACCCGCCTGCTCTGCGAGCTGTCGGTCCAGCGGCAAAACC TGGTTCAGTTGTTTGAGA CGGACCCGGTCACCTTCTTGTACCACCGCCCCGCCATCGGGGTCATCGTAGGCTGCGAGT TGATGCTACGCTTTGTGG CCGTGGGTCTCATCGTCGGCACCGCTTTCATATCCCGGGGGGCATGTGCAATCACATACC CCCTGTTTCTGACCATCA CCACCTGGTGTTTTGTCTCCACCATCGGCCTGACAGAGCTGTATTGTATTCTGCGGCGGG GCCCGGCCCCCAAGAACG CAGACAAGGCCGCCGCCCCGGGGCGATCCAAGGGGCTGTCGGGCGTCTGCGGGCGCTGCT GTTCCATCATCCTCTCGG GCATCGCAGTGCGATTGTGTTATATCGCCGTGGTGGCCGGGGTGGTGCTCGTGGCGCTTC ACTACGAGCAGGAGATCC AGAGGCGCCTGTTTGATGTATGACGTCACATCCAGGCCGGCGGAAACCGGAACGGCATAT GCAAATTGGAAACTGTCC TGTCTTGGGGCCCACCCACCCGACGCGTCATATGCAAATGAAAATCGGTCCCCCGAGGCC ACGTGTAGCCTGGATCCC AACGACCCCGCCCATGGGTCCCAATTGGCCGTCCCGTTACCAAGACCAACCCAGCCAGCA TATCCACCCCCGCCCGGG TCCCCGCGGAAGCGGAACGGTGTATGTGATATGCTAATTAAATACATGCCACGTACTTAT GGTGTCTGATTGGTCCTT GTCTGTGCCGGAGGTGGGGCGGGGGCCCCGCCCGGGGGGCGGAACGAGGAGGGGTTTGGG AGAGCCGGCCCCGGCACC ACGGGTATAAGGACATCCACCACCCGGCCGGTGGTGGTGTGCAGCCGTGTTCCAACCACG GTCACGCTTCGGTGCCTC TCCCCGATTCGGGCCCGGTCGCTCGCTACCGGTGCGCCACCACCAGAGGCCATATCCGAC ACCCCAGCCCCGACGGCA ACCGACAGCCCGGTCATGGCGACTGACATTGATATGCTAATTGACCTCGGCCTGGACCTC TCCGACAGCGATCTGGAC GAGGACCCACCCGAGCCGGCGGAGAGCCGCCGCGACGACCTGGAATCGGACAGCAGCGGG GAGTGTTCCTCGTCGGAC GAGGACATGGAAGACCCCCACGGAGAGGACGGACCGGAGCCGATACTCGACGCCGCTCGC CCGGCGGTCCGCCCGTCT CGTCCAGAAGACCCCGGCGTACCCAGCACCCAGACGCCTCGTCCGACGGAGCGGCAGGGC CCCAACGATCCTCAACCA GCGCCCCACAGTGTGTGGTCGCGCCTCGGGGCCCGGCGACCGTCTTGCTCCCCCGAGCAG CACGGGGGCAAGGTGGCC CGCCTCCAACCCCCACCGACCAAAGCCCAGCCTGCCCGCGGCGGACGCCGCGGGCGTCGC AGGGGTCGGGGTCGCGGT GGTCCCGGGGCCGCCGATGGTTTGTCGGACCCCCGCCGGCGTGCCCCCAGAACCAATCGC AACCCGGGGGGACCCCGC CCCGGGGCGGGGTGGACGGACGGCCCCGGCGCCCCCCATGGCGAGGCGTGGCGCGGAAGT GAGCAGCCCGACCCACCC GGAGGCCCGCGGACACGGGGCGTGCGCCAAGCACCCCCCCCGCTAATGACGCTGGCGATT GCCCCCCCGCCCGCGGAC CCCCGCGCCCCGGCCCCGGAGCGAAAGGCGCCCGCCGCCGACACCATCGACGCCACCACG CGGTTGGTCCTGCGCTCC ATCTCCGAGCGCGCGGCGGTCGACCGCATCAGCGAGAGCTTTGGCCGCAGCGCACAGGTC ATGCACGACCCCTTTGGG GGGCAGCCGTTTCCCGCCGCGAATAGCCCCTGGGCCCCGGTGTTGGCGGGCCAAGGAGGG CCCTTTGACGCCGAGACC AGACGGGTCTCCTGGGAAACCTTGGTCGCCCACGGCCCGAGCCTCTATCGCACTTTTGCC GGCAATCCTCGGGCCGCA TCGACCGCCAAGGCCATGCGCGACTGCGTGCTGCGCCAAGAAAATTTCATCGAGGCGCTG GCCTCCGCCGACGAGACG CTGGCGTGGTGCAAGATGTGCATCCACCACAACCTGCCGCTGCGCCCCCAGGACCCCATT ATCGGGACGGCCGCGGCT GTGCTGGATAACCTCGCCACGCGCCTGCGGCCCTTTCTCCAGTGCTACCTGAAGGCGCGA GGCCTGTGCGGCCTGGAC GAACTGTGTTCGCGGCGGCGTCTGGCGGACATTAAGGACATTGCATCCTTCGTGTTTGTC ATTCTGGCCAGGCTCGCC AACCGCGTCGAGCGTGGCGTCGCGGAGATCGACTACGCGACCCTTGGTGTCGGGGTCGGA GAGAAGATGCATTTCTAC CTCCCCGGGGCCTGCATGGCGGGCCTGATCGAAATCCTAGACACACACCGCCAGGAGTGT TCGAGTCGTGTCTGCGAG TTGACGGCCAGTCACATCGTCGCCCCCCCGTACGTGCACGGCAAATATTTTTATTGCAAC TCCCTGTTTTAGGTACAA TAAAAACAAAACATTTCAAACAAATCGCCCCACGTGTTGTCCTTCTTTGCTCATGGCCGG CGGGGCGTGGGTCACGGC AGATGGCGGGGGTGGGCCCGGCGTACGGCCTGGGTGGGCGGAGGGAACTAACCCAACGTA TAAATCCGTCCCCGCTCC AAGGCCGGTGTCATAGTGCCCTTAGGAGCTTCCCGCCCGGGCGCATCCCCCCTTTTGCAC TATGACAGCGACCCCCCT CACCAACCTGTTCTTACGGGCCCCGGACATAACCCACGTGGCCCCCCCTTACTGCCTCAA CGCCACCTGGCAGGCCGA AACGGCCATGCACACCAGCAAAACGGACTCCGCTTGCGTGGCCGTGCGGAGTTACCTGGT CCGCGCCTCCTGTGAGAC CAGCGGCACAATCCACTGCTTTTTCTTTGCGGTATACAAGGACACCCACCACACCCCTCC GCTGATTACCGAGCTCCG CAACTTTGCGGACCTGGTTAACCACCCGCCGGTCCTACGCGAACTGGAGGATAAGCGCGG GGTGCGGCTGCGGTGTGC GCGGCCGTTTAGCGTCGGGACGATTAAGGACGTCTCTGGGTCCGGCGCGTCCTCGGCGGG AGAGTACACGATAAACGG GATCGTGTACCACTGCCACTGTCGGTATCCGTTCTCAAAAACATGCTGGATGGGGGCCTC CGCGGCCCTACAGCACCT GCGCTCCATCAGCTCCAGCGGCATGGCCGCCCGCGCGGCAGAGCATCGACGCGTCAAGAT TAAAATTAAGGCGTGATC TCCAACCCCCCCATGAATGTGTGTAACCCCCCAAAAAAATAAACAGCCGTAACCCAATCA AACCAGGCGTGGTGTGAG T T T GT GGAC C C AAAG C C C T C AGAGACAAC G C GAC AG G C C AGT AT GGAC C GT GAT AC T T T TAT T TAT T AAC T C ACAG G G G C G C T T AC C G C CAC AGGAAT AC C AGAAT AAT GAC CAC C AC TAT C GC GAC C AC C C CAAAT ACAG CAT G G C G C C C CAC C A CGCCACAACAGCCCTGTCGCCGGTATGGGGCATGATCAGACGAGCCGCGAGCCGCGCGTT GGGCCCTGTACAGCTCGC GCGAATTGACCCTAGGAGGCCGCCACGCGCCCGAGTTTTGCGTTCGTCGCTGGTCGTCGG GCGCCAAAGCCCCGGACG GCTGTTCGGTCGAACGAACGGCCACGACAGTGGCATAGGTTGGGGGGTGGTCCGACATAG CCTCGGCGTACGTCGGGA GGCCCGACAAGAGGTCCCTTGAGATGTCGGGTGGGGCCACAAGCCTGGTTTCCGGAAGAA ACAGGGGGGTTGCCAATA ACCCGCCAGGGCCAAAACTCCGGCGCTGCGCACGTCGTTCGGCGCGGCGCCGGGCGCGCC GAGCGGCTCGCTGGGCGG CTTGGCGTGAGCGGCCCCGCTCCGACGCCTCGCCCTCTCCGGAGGAGGTTGGCGGAATTG GCACGGACGACAGGGGCC CAGCAGAGTACGGTGGAGGTGGGTCCGTGGGGGTGTCCAGATCAATAACGACAAACGGCC CCTCGTTCCTACCAGACA AGCTATCGTAGGGGGGCGGGGGATCAGCAAACGCGTTCCCCGCGCTCCATAGACCCGCGT CGGGTTGCGCCGCCTCCG AAGCCATGGATGCGCCCCAAAGCCACGACTCCCGCGCGCTAGGTCCTTGGGGTAAGGGAA AAGGCCCTACTCCCCATC CAAGCCAGCCAAGTTAACGGGCTACGCCTTCGGGGATGGGACTGGCACCCCGGCGGATTT TGTTGGGCTGGTACGCGT TGCCCAACCGAGGGCCGCGTCCACGGGACGCGCCTTTTATAACCCCGGGGGTCATTCCCA ACGATCACATGCAATCTA ACTGGCTCCCCTCTCCCCCCCTCTCCCCTCTCCCCCCCTCTCCCCTCTCCCCCCCTCTCC CCTCTCCCCCCCTCTCCC CTCTCCCCCCCTCTCCCCTCTCCCCCCCTCTCCCCTCTCCCCCCCTCTCCCCTCTCCCCC CCTCTCCCCTCTCCCCCC CTCTCCCCTCTCCCCCCCTCTCCCCTCTCCCCTCTGCTCTTTCCCCGTGACACCCGACGC TGGGGGGCGTGGCTGCCG GGAGGGGCCGCGGATGGGCGGGGCCTACTTGGTTTCCCGCCCCCCCCCCCCGCCCCCGAA CCGCCCCGCCGGCCTTGC CCCCCTTTGATCCCCTGCTACCCCCAACCCGTGCTGGTGGTGCGGGTTGGGGGGGGAGTG TGGGCGGGGGTGTGCGGG AGGTGTCGGTGGTGGTGGTGGTGGTGGTAGTAGGAATGGTGGTGAGGGGGGGGGGGCGCT GGTTGGTCAAAAAAGGGA GGGACGGGGGCCGGCAGACCGACGGCGACAACGCTCCCCGGTGGCCGGGTCGCGGCTCTT ACGAGCGGCCCGGCCCGC GCTCCCACCCCCCGGGCCGTGTCCTTGCTTTCCCCCCGTCTCCCCCCCCCCCGCCTTCTC CTCCTCCTCCTCGTTTTT CCAAACCCCGCCCACCCGGCCCGGCCCGGCCCGGCCCGGCCCGGCCACCGCCGCCCACCC ACCCACCTCGGGAGACCC AGCCCCGGTCCCCCGTTCCCCGGGGGCCGTTATCTCCAGCGCCCCGTCCGGCGCGCCGCC CCCCGCCGCTAAACCCCA TCCCGCCCCCGGGACCCCACATATAAGCCCCCAGCCACACGCAAGAACAGACACGCAGAA CGGCTGTGTTTATTTAAA TAAACCGATGTCGGAATAAACAAACACAAACACCCGCGACGGGGGGACGGAGGGGACGGA GGGAGGGGGGTGACGGGG GACGGGAACAGACACACCACAAAAAACACCCACCCACCGACACCCCCACCCCAGTCTCCT CGCCTTCTCCCACCCACC CCACGCCCCCACTGAGCCCGGTCGATCGACGAGCACCCCCGCCCACGCCCCCGCCCCTGC CCCGGCGACCCCCGGCCC GCACGATCCCGACAACAATAACAACCCCAACGGAAAGCGGCGGGGTGTGGGGGGGGGCGA GGAACAACCGAGGGGAAC GGGGGATGGAAGGACGGGAAGTGGAAGTCCTGATACCCATCCTACACCCCCCTGCCTTCC ACCCTCCGGCCCCCCGCG AGTCCACCCGCCGGCCGGCTACCGAGACCGAACACGGCGGCCGCCGCAGCCGCCGCAGCC GCCGCCGACACCGCAGAG CCGGCGCGCGCACACACAAGCGGCAGAGGCAGAAAGGCCCAGAGTCATTGTTTATGTGGC CGCGGGCCAGCAGACGGC CCGCGACACCCCCCCCCCGCCCGTGTGGGTATCCGGCCCCCCGCCCCGCGCCGGTCCATT AAGGGCGCGCGTGCCCGC GAGATATCAATCCGTTAAGTGCTCTGCAGACAGGGGCACCGCGCCCGGAAATCCATTAGG CCGCAGACGAGGAAAATA AAATTACATCACCTACCCACGTGGTGCTGTGGCCTGTTTTTGCTGCGTCATCTGAGCCTT TATAAAAGCGGGGGCGCG GCCGTGCCGATCGCGGGTGGTGCGAAAGACTTTCCGGGCGCGTCCGGGTGCCGCGGCTCT CCGGGCCCCCCTGCAGCC GGGGCGGCCAAGGGGCGTCGGCGACATCCTCCCCCTAAGCGCCGGCCGGCCGCTGGTCTG TTTTTTGTTTTCCCCGTT TCGGGGGTGGGGGGGGTTGCGGTTTCTGTTTCTTTAACCCGTCTGGGGTGTTTTTCGTTC CGTCGCCGGAATGTTTCG TTCGTCTGTCCCCTCACGGGGCGAAGGCCGCGTACGGCCCGGGACGAGGGGGCCCCCGAC CGCGGCGGTCCGGGCCCC GTCCGGGCCCGCTCGCCGGCACGCGACGCGAAAAAGGCCCCCCGGAGGCTTTTCCGGGTT CCCGGCCCGGGGCCTGAG ATAAACAATCGGGGTTACCGCCAACGGCCGGCCCCCGTGGCGGCCCGGCCCGGGGCCCCG GCGGACCCAAGGGGCCCC GGCCCGGGGCCCCACAACGGCCCGGCGCATGCGCTGTGGTTTTTTTTTTTCTCGGTGTTC TGCCGGGCTCCATCGCCT TTCCTGTTCTCGCTTCTCCCCCCCCCCTTCTTCACCCCCAGTACCCTCCTCCCTCCCTTC CTCCCCCGTTATCCCACT CGTCAAGGGCGCCCCGGTGTGGTTCAACAAAGACGCCGCGTTTCCAGGTAGGTTAGACAC CTGCTTCTCCCCAATAGA GGGGGGGGACCCAAACGACAGGGGGCGCCCCAGAGGCTAAGGTCGGCCACGCCACTCGCG GGTGGGCTCGTGTTACAG CACACCAGCCCGTTCTTTTCCCCCCCTCCCACCCTTAGTCAGACTCTGTTACTTACCCGT CCGACCACCAACTGCCCC CTTATCTAAGGGCCGGCTGGAAGACCGCCAGGGGGTCGGCCGGTGTCGCTGTAACCCCCC ACGCCAATGACCCACGTA CTCCAAGAAGGCATGTGTCCCACCCCGCCTGTGTTTTTGTGCCTGGCTCTCTATGCTTGG GTCTTACTGCCTGGGGGG GGGGAGTGCGGGGGAGGGGGGGTGTGGAAGGAAATGCACGGCGCGTGTGTACCCCCCCTA AAGTTGTTCCTAAAGCGA GGATATGGAGGAGTGGCGGGTGCCGGGGGACCGGGGTGATCTCTGGCACGCGGGGGTGGG AAGGGTCGGGGGAGGGGG GATGGGGTACCGGCCCACCTGGCCGACGCGGGTGCGCGTGCCTCTGCACACCAACCCCAC GTCCCCCGGCGGTCTCTA AGAAGCACCGCCCCCCCTCCTTCATACCACCGAGCATGCCTGGGTGTGGGTTGGTAACCA ACACGCCCATCCCCTCGT CTCCTGTGATTCTCTGGCTGCACCGCATTCTTGTTTTCTAACTATGTTCCTGTTTCTGTC TCCCCCCCCCCCACCCCT CCGCCCCACCCCCCAACACCCACGTCTGTGGTGTGGCCGACCCCCTTTTGGGCGCCCCGT CCCGCCCCGCCACCCCTC CCGTCCTTTGTTGCCCTATAGTGTAGTTAACCCCCCCCGCCCTTTGTGGCGGCCAGAGGC CAGGTCAGTCCGGGCGGG CAGGCGCTCGCGGAAACTTAACACCCACACCCAACCCACTGTGGTTCTGGCTCCATGCCA ATGGCAGGATGCTTTCGG GGATCGGTGGTCAGGCAGCCCGGGCCGCGGCTCTGTGGTTAACACCAGAGCCTGCCCAAC ATGGCACCCCCACTCCCA CGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACT CCCACGCACCCCCACTCC CACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCACTCCCACGCACCCCCG AGATCCATCCAACACAGA C AG G GAAAAGAT AC AAAAGT AAAC C T T TAT T T C C CAAT AGAC AG CAAAAAT C C C CT GAGT T T T T TAT TAG G G C CAAC A CTAAAGACCCGCTGGTGTGTGGTGCCCGTGTCTTTCACTTTTCCCCTCCCCGACACGGAT TGGCTGGTGTAGTGGGCG CGGCCAGAGACCACCCAGCGCCCGACCCCCCCCTCCCCACAAACACGGGGGGCGTCCCTT ATTGTTTTCCCTCGTCCC GGGTCGACGCCCCCTGCTCCCCGGACCACGGGTGCCGAGACCGCAGGCTGCGGAAGTCCA GGGCGCCCACTAGGGTGC CCTGGTCGAACAGCATGTTCCCCACGGGGGTCATCCAGAGGCTGTTCCACTCCGACGCGG GGGCCGTCGGGTACTCGG GGGGCATCACGTGGTTACCCGCGGTCTCGGGGAGCAGGGTGCGGCGGCTCCAGCCGGGGA CCGCGGCCCGCAGCCGGG TCGCCATGTTTCCCGTCTGGTCCACCAGGACCACGTACGCCCCGATGTTCCCCGTCTCCA TGTCCAGGATGGGCAGGC AGTCCCCCGTGATCGTCTTGTTCACGTAAGGCGACAGGGCGACCACGCTAGAGACCCCCG AGATGGGCAGGTAGCGCG TGAGGCCGCCCGCGGGGGCGGCCCCGGAAGTCTCCGCGTGGCGCGTCTTCCGGGCACACT TCCTCGGCCCCCGCGGCC CAGAAGCAGCGCGGGGGCCGAGGGAGGTTTCCTCTTGTCTCCCTCCCAGGGCACCGACGG CCCCGCCCGAGGAGGCGG AAGCGGAGGAGGACGCGGCCCCGGCGGCGGAAGAGGCGGCCCCCGCGGGAGTCGGGGCCG AGGAGGAAGAGGCAGAGG AGGAAGAGGCGGAGGCCGCCGAGGACGTCAGGGGGGTCCCGGGCCCACCCTGGCCGCGCC CCCCCGGCCCTGAGTCGG AGGGGGGGTGCGTCGCCGCCCTCTTGGCCCCTGCCGGCGCGAGGGGGGGACGCGTGGACT GGGGGGAGGGGTTTTCCT GGCCCGACCCGCGCCTCTTCCTCGGACGCACCGCCGCCTCCTGCTCGACAGAGGCGGCGG AGGGGAGCGGGGGGGCGC CGGAGGGGGCGGCGCCGCGGGAGGGCCCGTGTCCACCCTCCACGCCCGGCCCCCCCGAGC CGCGCGCCACCGTCGCAC GCGCCCGGCACAGACTCTGTTCTTGGTTCGCGGCCTGAGCCAGGGACGAGTGCGACTGGG GCACACGGCGCGCGTCCG CGGGGCGGGCGGCCGGCTCCGCCCCGGGGGCCGGGGCGCGGGGGCCGGGCCCCGGAGGCG GCGCTCGCACGCACGGGG CCACGGCCGCGCGGGGGCGCGCGGGTCCCGACGCGGCCGAGGACGCGGTGGGCCCGGGGC GGGGGGCGGAGCCTGGCA TGGGCGCCGCGGGGGGCCTGTGGGGAGAGGCCGGGGGGGAGTCGCTGATCACTATGGGGT CTCTGTTGTTTGCAAGGG GGGCGGGTCTGTTGACAAGGGGGCCCGTCCGGCCCCTCGGCCGCCCCGCCTCCGCTTCAA CAACCCCAACCCCAACCC CAACCCCCCCGGAGGGGCCAGACGCCCCCCGCGGCGCCGCGGCTCGCGACTGGCGGGAGC CGCCGCCGCCGCTGCTGT TGGTGGTGGTGTTGGTGTTACTGCTGCCGTGTGGCCCGATGGGCGCCGAGGGGGGCGCTG TCCGAGCCGCGGCCGGCT GGGGGGCTGCGTGAGACGCCCCGCCCGTCACGGGGGGCGCGGCGGCGCCTCTGCGTGGGG GGGCGCGGGGCGTCCGGC GGGGGGCGGGCGGTACGTAGTCTGCTGCAAGAGACAACGGGGGGCGCGATCAGGTTACGC CCCCTCCCAGGCCCTCCC TTTCCGCGCCCGCCCGCCTATTCCTCCCTCCCCCCTCCTCCTCCTCCTCCCCCAGGGTCC TCGCCGCCCCCCGCCTCA CCGTCGTCCAGGTCGTCGTCATCCTCGTCCGTGGTGGGCTCAGGGTGGGTGGGCGACAGG GCCCTCACCGTGTGCCCC CCCAGGGTCAGGTACCGCGGGGCGAACCGCTGATTGCCCGTCCAGATAAAGTCCACGGCC GTGCCCGCCCTGACGGCC TCCTCGGCCTCCATGCGGGTCTGGGGGTCGTTCACGATCGGGATGGTGCTGAACGACCCG CTGGGCGTCACGCCCACT ATCAGGTACACCAGCTTGGCGTTGCACAGCGGGCAGGTGTTGCGCAATTGCATCCAGGTT TTCATGCACGGGATGCAG AAGCGGTGCATGCACGGGAAGGTGTCGCAGCGCAGGTGGGGCGCGATCTCATCCGTGCAC ACGGCGCACACGTCGCCC TCGTCGCTCCCCCCGTCCTCTCGAGGGGGGGCGCCCCCGCAACTGCCGGGGTCTTCCTCG CGGGGGGGGCTCCCCCCC GAGACCGCCCCCCCATCCACGCCCTGCGGCCCCAGCAGCCCCGTCTCGAACAGTTCCGTG TCCGTGCTGTCCGCCTCG GAGGCGGAGTCGTCGTCATGGTGGTCGGCGTCCCCCCGCCCCCCCACTTCGGTCTCCGCC TCAGAGTCGCTGCTGTCC GGCAGGTCTCGGTCGCAGGGAAACACCCAGACATCCGGGGCGGGCTAAGGGGAAAAAAGG GGGGCGGGTAAGAATGGG GGGATTTCCCGCGTCAATCAGCGCCCACGAGTTCCCCCTCTCCCCCCCCCGCCTCACAAA GTCCTGCCCCCCTGCTGG CCTCGGAAGAGGGGGGAGAAAGGGGTCTGCAACCAAAGGTGGTCTGGGTCCGTCCTTTGG ATCCCGACCCCTCTTCTT CCCTCTTCTCCCGCCCTCCAGACGCACCGGAGTCGGGGGTCCCACGGCGTCCCCCAAATA TGGCGGGCGGCTCCTCCC CACCCCCCTAGATGCGTGTGAGTAAGGGGGCCCTGCGTATGAGTCAGTGGGGACCACGCC CCCTAACACGGCGACCCC GGTCCTTGTGTGTTTGTTGTGGGGGCGTGTCTCTGTGTATGAGTCAGGGGGTCCCACGGC GACCCCGGGCCCTGCGTC TGAGTCAAAGGGGCCATGTGTATGTGTTGGGGGGTCTGTATATATAAAGTCAGGGGGTCA CATGGCGACCCCCAACAG GGCGACCCCGGTCCCTGTATATATAGGGTCAGGGGGTTCCGCGCCCCCTAACATGGCGCC CCCGGTCCCTGTATATAT AGTGTCACGGGGTTCCACGCCCCCTAACATGGCGCCCGCCCGGCTCCCGTGTATGAGTGG GGGTCCCCCAACATGGCG GCCGGTTCCAGTGTAAGGGTCGGGGGTCCCCCAACATGGCGCCCCCCAATATGGCGCCCC CCAATATGGCGCCCCAGA CATGGCGCCCGGCCCCTCACCTCGCGCTGGGGGCGGCCCTCAGGCCGGCGGGTACTCGCT CCGGGGCGGGGCTCCATG GGGGTCGTATGCGGCTGGAGGGTCGCGGACGGAGGGTCCCTGGGGGTCGCAACGTAGGCG GGGCTTCTGTGGTGATGC GGAGAGGGGGCGGCCCGAGTCTGCCTGGCTGCTGCGTCTCGCTCCGAGTGCCGAGGTGCA AATGCGACCAGACTGTCG GGCCAGGGCTAACTTATACCCCACGCCTTTCCCCTCCCCAAAGGGGCGGCAGTGACGATT CCCCCAATGGCCGCGCGT CCCAGGGGAGGCAGGCCCACCGCGGGGCGGCCCCGTCCCCGGGGACCAACCCGGCGCCCC CAAAGAATATCATTAGCA TGCACGGCCCGGCCCCCGATTTGGGGGACCAACCCGGTGTCCCCCAAAGAACCCCATTAG CATGCCCCTCCCACCGAC GCAACAGGGGCTTGGCCTGCGTCGGTGCCCCGGGGCTTCCCGCCTTCCCGAAGAAACTCA TTACCATACCCGGAACCC CAGGGGACCAATGCGGGTTCATTGAGCGACCCGCGGGCCAATGCGCGAGGGGCCGTGTGT TCCGCCAAAAAAGCAATT AGCATAACCCGGAACCCCAGGGGAGTGGTTACGCGCGGCGCGGGAGGCGGGGAATACCGG GGTTGCCCATTAAGGGCC GCGGGAATTGCCGGAAGCGGGAAGGGCGGCCGGGGCCGCCCATTAATGAGTTTCTAATTA CCATACCGGGAAGCGGAA CAAGGGTTACCTGGGACTGTGCGGTTGGGACGGCGCCCGTGGGCCCGGGCGGCCGGGGGC GGCGGGGGCCGCGATGGC GGCGGCGGCGGGCCATGGAGACAGAGAGCGTGCCGGGGTGGTAGAGTTTGACAGGCAAGC ATGTGCGTGCAGAGGCGA GTAGTGCTTGCCTGTCTAACTCGCTCGTCTCGGCCGCGGGGGGCCCGGGCTGCCGCCGCC GCGCTTTAAAGGGCCGCG CGCGACCCCCGGGGGGTGTGTTTTGGGGGGGGCCCGTTTTCGCTCCTCCCCCCGCTCCTC CCCCCGCTCCTCCCCCCG CTCCTCCCCCCGCTCCTCCCCCCGCTCCTCCCCCCGCTCCTCCCCCCGCTCCTCCCCCCG CTCCTCCCCCCGCTCCTC CCCCCGCTCCTCCCCCCGCTCCTCCCCCCGCTCCTCCCCCCGCTCCTCCCCCCGCTCCTC CCCCCGCTCCTCCCCCCG CTCCTCCCCCCGCTCCTCCCCCCGCTCCCGCGGCCCCGCCCCCAACGCCCGCCGCGCGCG CGCACGCCGCCCGGACCG CCGCCCGCCTTTTTTGCGCGCGCCCCGCCCGCGGGGGGCCCGGGCTGCCACAGGTGTAAC AACACACACGGCTCATCC ACAC GT C AC AC GT C AC GT CAT C C AC CAC AC C T G C C C AC C AAC AC AAC T C ACAG C GAC AAC T C AC C G C G CAAC AAC T C C TGTTCCTCATCCACACGTCACCGCGCACCCCCCGCTCCTCCAGACGTCCCCCAGCGCAAC ACGCCGCTCCTGCTACAC ACCACCGCCCCCTCCCCAGCCCCAGCCCTCCCCAGCCCCAGCCCTCCCCAGCCCCAGCCC TCCCCGGCCCCAGCCCTC CCCGGCCCCAGCCCTCCCCGGCCCCAGCCCTCCCCGGCCCCAGCCCTCCCCGGCCCCAGC CCTCCCCGCCGCGTCCCG CGCTCCCTCGGGGGGGTTCGGGCATCTCTACCTCAGTGCCGCCAATCTCAGGTCAGAGAT CCAAACCCTCCGGGGGCG CCCGCGCACCACCACCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCC CCCTCCCGCCCCTCGCCC CCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCC CCTCGCCCCCTCCCGCCC CTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCC TCCCGCCCCTCGCCCCCT CCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCT CGCCCCCTCCCGCCCCTC GCCCCCTCCCGCCCCTCGCCCCCTCCCGCCCCTCAAATAAACAACGCTACTGCAAAACTA AATCAGGTCGTTGTCGTT TATTGTGTCTTCGGGTTTCGCAAGCGCCCCGCCCCGTCCCGGCCCGTTACAGCACCCCGT CCCCCTCGAACGCGCCGC CGTCGTCGTCGTCCCAGGCGCCTTCCCAGTCCACAACTTCCCGTCGCGGGGGCGTGGCCA AGCCCGCCTCCGCCCCCA GCACCTCCACGGCCCCCGCCGCCGCCAGCACGGTGCCGCTGCGGCCCGTGGCCGAGGCCC AGCGAATCCCGGGCAACG CCGGCGGCAGGGCCCCCGGGCCGTCGTCGYCGCCGCGCAGCACCAGCGGGGGGGCGTCGT CGTCGGGCTCCAGCAGGG CGCGGGCGCAAAAGTCCCTCCGCGGCCCGCGCCACCGGGCCGGGCCGGCGCGCACCGCCT CGCGCCCCAGCGCCACGT ACACGGGCCGCAGCGGCGCGCCCAGGCCCCAGCGCGCGCAGGCGCGGTGCGAGTGGGCCT CCTCCTCGCAGAAGTCCG GCGCGCCGGGCGCCATGGCGTCGGTGGTCCCCGAGGCCGCCGCCCGGCCGTCCAGCGCCG GCAGCACGGCCCGGCGGT ACTCGCGCGGGGACATGGGCACCGGCGTGTCCGGGCCGAAGCGCGTGCGCACGCGGTAGC GCACGTTGCCGCCGCGGC ACAGGCGCAGCGGCGGCGCGTCGGGGTACAGGCGCGCGTGCGCGGCCTCCACGCGCGCGA AGACCCCCGGGCCGAACA CGCGGCCCGGGGCCAGCACCGTGCGGCGCAGGTCCCGCGCCGCCGGCCAGCGCACGGCGC ACTGCACGGCGGGCAGCA GGTCGCACGCCAGGTAGGCGTGCTGCCGCGACACCGCGGGCCCGTCGGCGGGCCAGTCGC AGGCGCGCACGGTGTTGA CCACGATGAGCCGCCGGTCGCCGGCGCTGGCGAGCAGCCCCAGAAACTCCACGGCCCCGG CGAAGGCCAGGTCCCGCG TGGACAGCAGCAGCACGCCCTGCGCGCCCAGCGCCGACACGTCGGGGGCGCCGGTCCAGT TGCCCGCCCAGGCGGCCG TGTCCGGCCCGCACAGCCGGTTGGCCAGGGCCGCCAGCAGGCAGGACAGCCCGCCGCGCT CGGCGGACCACTCCGGCG GCCCCCCCGAGGCCCCGCCGCCGGCCAGGTCCTCGCCCGGCAGCGGCGAGTACAGCACCA CCACGCGCACGTCCTCGG GGTCGGGGATCTGGCGCATCCAGGCCGCCATGCGGCGCAGCGGGCCCGAGGCGCGCAGGG GGCCAAAGAGGCGGCCCC CGGCGGCCCCGTGGGGGTGGGGGTTATCGTCGTCGTCGCCGCCGCCGCACGCGGCCTGGG CGGCGGGGGCGGGCCCGG CGCACCGCGCGGCGATCGAGGCCAGGGCCCGCGGGTCAAACATGAGGGCCGGTCGCCAGG GGACGGGGAACAGCGGGT GGTCCGTGAGCTCGGCCACGGCGCGCGGGGAGCAGTAGGCCTCCAGGGCGGCGGCCGCGG GCGCCGCCGTGTGGCTGG GCCCCGGGGGCTGCCGCCGCCAGCCGCCCAGGGGGTCGGGGCCCTCGGCGGGCCGGCGCG ACACGGCCACGGGGCGCG GGCGGGCCTGCGCCGCGGCGGCCCGGGGCGCCGCGGGCTGGGCGGGGGCGGGCTCGGGCC CCGGGGGCGTGGAGGGGG GCGCGGGCGCGGGGAGGGGGGCGCGGGCGTCCGAGCCGGGGGCGTCCGCGCCGCTCTTCT TCGTCTTCGGGGGTCGCG GGCCGCCGCCTCCGGGCGGCCGGGCCGGGCCGGGACTCTTGCGCTTGCGCCCCTCCCGCG GCGCGGCGGAGGCGGCGG CGGCCGCCAGCGCGTCGGCGGCGTCCGGTGCGCTGGCGGCCGCCGCCAGCAGGGGGCGCA GGCTCTGGTTCTCAAACA GCAGGTCCGCGGCGGCGGCGGCCGCGGAGCTCGGCAGGCGCGGGTCCCGCGGCAGCGCGG GGCCCAGGGCCCCGGCGA CCAGGCTCACGGCGCGCACGGCGGCCACGGCGGCCTCGCTGCCGCCGGCCACGCGCAGGT CCCCGCGCAGGCGCATGA GCACCAGCGCGTCGCGCACGAACCGCAGCTCGCGCAGCCACGCGCGCAGGCGGGGCGCGT CGGCGTGCGGCGGCGGCG GGGAAGCGGGGCCCGCGGGTCCCTCCGGCCGCGGGGGGCTGGCGGGCCGGGCCCCGGCCA GCCCCGGGACGGCCGCCA GGTCGCCGTCGAAGCCCTCGGCCAGCGCCTCCAGGATCCCGCGGCAGGCGGCCAGGCACT CCACGGCCACGCGGCCGG CCTGGGCGCGGCGCCCGGCGTCGTCGTCGGCGTCGGCGTGGCGGGCGGCGTCGGGGTCGT CGCCCCCCGCGGGGGAGG CGGGCGCGGCGGACAGCCGCCCCAGGGCGGCGAGGATCCCCGCGGCGCCGTACCCGGCGG GCACCGCGCGCTCGCCCG GTGCGGCGACGACGGCGGCGGCGACCCCCTCGTCATCTGCGCCGGCGCCGGGGCTCCCCG CGGCCCCCGTCAGCGCCG CGTTCTCGCGCGCCAACAGGGGCGCGTAGGCGCGGCGCAGGCTGGTCAGCAGGAAGCCCT TCTGCGCGCGGTCGTATC GGCGGCTCATGGCCACGGCGGCCGCCGCGTGCGCCAGGCCCCAGCCGAAGCGGCCGGCCG CCATGGCGTAGCCCAGGT GGGGCACGGCCCGCGCCACGCTGCCGGTGATGAAGGAGCTGCTGTTGCGCGCGGCGCCCG AGATCCGGAAGCAGGCCT GGTCCAGCGCCACGTCCCCGGGGACCACGCGCGGGTTCTGGAGCCACCCCATGGCCTCCG CGTCCGGGGTGTACAGCA GCCGCGTGATCAGGGCGTACTGCTGCGCGGCGTCGCCCAGCTCGGGCGCCCACACGGCCG CCGGGGCGCCCGAGGCCT CGAACCGGCGTCGCGCCTCCTCCGCCTCGGGCGCCCCCCAGAGGCCCGGGCGGCTGTCGC CCAGGCCGCCGTACAGCA CCCGCCCCGGGGGCGGGGGCCCGGCGCCGGGCCACGGCTCCCCGCTGACGTACCCGTCGC GATAGCGCGCGTAGAAGG CGCCGGAGGCCGCGTCGGCGTCCAGCTCGACCCGCCGGGGCTGCCCGGCCGTGAAGCGGC CCGTGGCGTCGCGGCCGG CCACCGCCGCGCGGGCCCGGCGGCGCTCGATGCGGCCCGCGGAGGCCGCGGGGGTCCTCG CCGCCGCCCGGGGCTTGG GCGCGGCCTCGGAGAGGGGGGGTGGCCCGGGCGGGGGCGGCGTCCGCCCGGGGGCTTCCG GCGCCGCGCTCGACGGAC CCCGCCCGACGGCCCGCGCCTCGCGTGCGCGGTCGGCCGCGTCGTTGCCGTCGTCGTCCT CGTCCTCGTCGGACGACG AGGACGAAGAGGATGCGGACGACGAGGACGAGGACCCGGAGTCCGACGAGGTCGATGACG CCGATGGCCGCCGCCGGC CGTGACGACGTCTCCGCGGCGGCTGGGCCGGCGGGCGCGGCGACAGGCGGTCCGTGGGGT CCGGATACGCGCCGCGTA GCGGGGCCTCCCGTGCGCGGCCCCGGGCCGGGGCCCGGTCGCCGGCGGCGTCGGCTGCGT CGTCGTACTCGTCCCCGT CATCGTCGTCGGCTCGAAAGGCGGGGGTCCGGGGCGGCGAGGCCGCGGGGTCGGGCGTCG GGATCGTCCGGACGGCCT CCTCTACCATGGAGGCCAGCAGGGCCAGCTGTCGCGGCGAGACGGCGTCCCCGGCGTCCT CGCCGGCGTCGGTGCCCG CCGCGGGGGCCCTCCCGTCCCGCCGGGCGTCGTCGAGGTCGTGGGGGTGGTCGGGGTCGT GGTCGGGGTCGTCCCCGC CCTCCTCCGTCTCCGCGCCCCACCCGAGGGCCCCCCGCTCGTCGCGGTCTGGGCTCGGGG TGGGCGGCGGCCCGTCGG TGGGGCCCGGGGAGCCGGGGCGCTGCTTGTTCTCCGACGCCATCGCCGATGCGGGGCGAT CCTCCGGGGATACGGCTG CGACGGCGGACGTAGCACGGTAGGTCACCTACGGACTCTCGATGGGGAGGGGGCGAGACC CACGGACCCCGACGACCC CCGCCGTCGACGCGGAACTAGCGCGGACCGGTCGATGCTTGGGTGGGAAAAAGGACAGGG ACGGCCGATCCCCCTCCC GCGCTTCGTCCGCGTATCGGCGTCCCGGCGCGGCGAGCGTCTGACGGTCTGTCTCTGGCG GTCCCGCGTCGGGTCGTG GATCCGTGTCGGCAGCCGCGCTCCGTGTGGACGATCGGGGCGTCCTCGGGCTCATATAGT CCCAGGGGCCGGCGGGAA GGAGGAGCAGCGGAGGCCGCCGGCCCCCCGCCCCCCAGGCGGGCCCGCCCCGAACGGAAT TCCATTATGCACGACCCC GCCCCGACGCCGGCACGCCGGGGGCCCGTGGCCGCGGCCCGTTGGTCGAACCCCCGGCCC CGCCCATCCGCGCCATCT GCCATGGGCGGGGCGCGAGGGCGGGTGGGCCCGCGCCCCGCCCCGCATGGCATCTCATTA CCGCCCGATCCGGTGGTT TCCGCTTCCGTTCCGCATGCTAACGAGGAACGGGCCGGGGGCGGGGCCCGGGCCCCGACT TCCCGGTTCGGCGGTAAT GAGATACGAGCCCCGCGCGCCCGTTGGCCGTCCCCGGGCCCCCGGTCCCGCCCGCCGGAC GTTGGGACCAACGGGACG GCGGGCGGCCCAAGGGCCGCCCGCCTTGCCGCCCCCCCATTGGCCGGCGGGCGGGACCGC CCCAAGGGGGCGGGGCCG CCGGGTAAAAGAAGTGAGAACGCGAAGCGTTCGCACTTCGTCCCAATATATATATATTAT TAGGGCGAAGTGCGAGCA CTGGCGCCGTGCCCGACTCCGCGCCGGCCCCGGGGGCGGGCCCGGGCGGCGGGGGGCGGG TCTCTCCGGCGCACATAA AGGCCCGGCGCGACCGACGCCCGCAGACGGCGCCGGCCACGAACGACGGGAGCGGCTGCG GAGCACGCGGACCGGGAG CGGGACTCGCAGAGGGCCGTCGGAGCGGACGGCGTCGGCATCGCGACGCCCCGGCTCGGG ATCGGGATCGCATCGGAA AGG GACAC G C G GAC AAGAC C C AC C C AC C C C AC C C AC GAAACAC AGG G GAC GC AC CCCGGGGGCCTCC GAC GAC AGAAA CCCACCGGTCCGCCTTTGTGCACGGGTAAGCACCTTGGGTGGGCGGAGGAGGGGGGACAC GGGGGCGGAGGAGGGGGG ACACGGGGGCGGAGGAGGGGGGACGCGGGGGCGGAGGAGGGGGGACGCGGGGGCGGAGGA GGGGGGACACGGGGGCGG AGGAGGGGGCTCACCCGCGTTCGTGCCTTCCCGCAGGAGGAACGTCCTCGTCGAGGCGAC CGGCGGCGACCGTTGCGT GGACCGCTTCCTGCTCGTCGGGCGGGGGGAAGCCACTGTGGTCCTCCGGGACGTTTTCTG GATGGCCGACATTTCCCC AGGCGCTTTTGCGCCTTGTGTAAAAGCGCGGCGTCCCGCTCTCCGATCCCCGCCCCTGGG CACGCGCAAGCGCAAGCG CCCTTCCCGCCCCCTCTCATCGGAGTCTGAGGTAGAATCCGATACAGCCTTGGAGTCTGA GGTCGAATCCGAGACAGC ATCGGATTCGACCGAGTCTGGGGACCAGGATGAAGCCCCCCGCATCGGTGGCCGTAGGGC CCCCCGGAGGCTTGGGGG GCGGTTTTTTCTGGACATGTCGGCGGAATCCACCACGGGGACGGAAACGGATGCGTCGGT GTCGGACGACCCCGACGA CACATCCGACTGGTCTTATGACGACATTCCCCCACGACCCAAGCGGGCCCGGGTAAACCT GCGGCTCACGAGCTCTCC CGATCGGCGGGATGGGGTTATTTTTCCTAAGATGGGGCGGGTCCGGTCTACCCGGGAAAC GCAGCCCCGGGCCCCCAC CCCGTCGGCCCCAAGCCCAAATGCAATGCTACGGCGCTCGGTGCGCCAGGCCCAGAGGCG GAGCAGCGCACGATGGAC CCCCGACCTGGGCTACATGCGCCAGTGTATCAATCAGCTGTTTCGGGTCCTGCGGGTCGC CCGGGACCCCCACGGCAG TGCCAACCGCCTGCGCCACCTGATACGCGACTGTTACCTGATGGGATACTGCCGAGCCCG TCTGGCCCCGCGCACGTG GTGCCGTTTGCTGCAGGTGTCCGGCGGAACCTGGGGCATGCACCTGCGCAACACCATACG GGAGGTGGAGGCTCGATT CGACGCCACCGCGGAACCCGTGTGCAAGCTTCCTTGTTTGGAGACCAGACGGTACGGCCC GGAGTGTGATCTTAGTAA TCTCGAGATTCATCTCAGCGCGACAAGCGATGATGAAATCTCCGATGCCACCGATCTGGA GGCCGCCGGTTCGGACCA CACGCTCGCGTCCCAGTCCGACACGGAGGATGCCCCCTCCCCCGTTACGCTGGAAACCCC AGAACCCCGCGGGTCCCT CGCTGTGCGTCTGGAGGATGAGTTTGGGGAGTTTGACTGGACCCCCCAGGAGGGCTCCCA GCCCTGGCTGTCTGCGGT CGTGGCCGATACCAGCTCCGTGGAACGCCCGGGCCCATCCGATTCTGGGGCGGGTCGCGC CGCAGAAGACCGCAAGTG TCTGGACGGCTGCCGGAAAATGCGCTTCTCCACCGCCTGCCCCTATCCGTGCAGCGACAC GTTTCTCCGGCCGTGAGT CCGGTCGCCCCGACCCCCTTGTATGTCCCCAAAATAAAAGACCAAAATCAAAGCGTTTGT CCCAGCGTCTTAATGGCG GGAAGGGCGGAGAGAAACAGACCACGCGTACATGGGGGGTGTTTGGGGGTTTATTGACAT CGGGGCTACAGGGTGGTA ACCGGATAGCAGATGTGAGGAAGTCTGGGCCGTTCGCCGCGAACGGCGATCAGAGGGTCC GTTTCTTGCGGACCACGG CCCGGTGATGTGGGTTGTTCGTCTGGGATCTCGGGCATGCCCATACACGCACAACACGGA CGCCGCACCGGATGGGAC GTCGTAAGGGGGCCTGGGGTAGCTGGGTGGGGTTTGTGCAGAGCAATCAGGGACCGCAGC CAGCGCATACAATCGCGC TCCCGTCCGTTTGTCCCGGGCAGTACCACGCCGTACTGGTATTCGTACCGGCTGAGCAGG GTCTCCAGGGGGTGGTTG GGGGCCGCGGGGAACGGGGTCCACGCCACGGTCCACTCGGGCAAAAACCGAGTCGGCACG GCCCACGGTTCTCCCACC CACGCGTCTGGGGTCTTGATGGCGATAAATCTTACCCCGAGCCGGATTTTTTGGGCGTAT TCGAGAAACGGCACACAC AGATCCGCCGCGCCTACCACCCACAAGTGGTAGAGGCGAGGGGGGCTGGGTTGGTCTCGG TGCAGCAGTCGGAAGCAC GCCACGGCGTCCACGACCTCGGTGCTCTCCAAGGGGCTGTCCTCCGCAAACAGGCCCGTG GTGGTGTTTGGGGGGCAG CGACAGGACCTAGTGCGCACGATCGGGCGGGTGGGTTTGGGTAAGTCCATCAGCGGCTCG GCCAACCGTCGAAGGTTG GCCGGACGAACGACGACCGGGGTACCCAGGGGTTCTGATGCCAAAATGCGGCACTGCCTA AGCAGGAAGCTCCACAGG GCCGGGCTTGCGTCGACGGAAGTCCGGGGCAGGGCGTTGTTCTGGTCAAGGAGGGTCATT ACGTTGACGACAACAACG CCCATGTTGGTATATTACAGGCCCGTGTCCGATTTGGGGCACTTGCAGATTTGTAAGGCC ACGCACGGCGGGGAGACA GGCCGACGCGGGGGCTGCTCTAAAAATTTAAGGGCCCTACGGTCCACAGACCCGCCTTCC CGGGGGGGCCCTTGGAGC GACCGGCAGCGGAGGCGTCCGGGGGAGGGGAGGGTGATTTACGGGGGGGTAGGTCAGGGG GTGGGTCGTCAAACTGCC GCTCCTTAAAACCCCGGGGCCCGTCGTTCGGGGTGCTCGTTGGTTGGCACTCACGGTGCG GCGAATGGCCTGTCGTAA GTTTTGTCGCGTTTACGGGGGACAGGGCAGGAGGAAGGAGGAGGCCGTCCCGCCGGAGAC AAAGCCGTCCCGGGTGTT TCCTCATGGCCCCTTTTATACCCCAGCCGAGGACGCGTGCCTGGACTCCCCGCCCCCGGA GACCCCCAAACCTTCCCA CACCACACCACCCGGCGATGCCGAGCGCCTGTGTCATCTGCAGGAGATCCTGGCCCAGAT GTACGGAAACCAGGACTA CCCCATAGAGGACGACCCCAGCGCGGATGCCGCGGACGATGTCGACGAGGACGCCCCGGA CGACGTGGCCTATCCGGA GGAATACGCAGAGGAGCTTTTTCTGCCCGGGGACGCGCCCGGTCCCCTTATCGGGGCCAA CGACCACATCCCTCCCCC GTGTGGCGCATCTCCCCCCGGTATACGACGACGCAGCCGGGATGAGATTGGGGCCACGGG ATTTACCGCGGAAGAACT GGACGCCATGGACAGGGAGGCGGCTCGAGCCATCAGCCGCGGCGGCAAGCCCCCCTCGAC CATGGCCAAGCTGGTGAC TGGCATGGGCTTTACGATCCACGGAGCGCTCACCCCAGGATCGGAGGGGTGTGTCTTTGA CAGCAGCCACCCAGATTA CCCCCAACGGGTAATCGTGAAGGCGGGGTGGTACACGAGCACGAGCCACGAGGCGCGACT GCTGAGGCGACTGGACCA CCCCGCGATCCTGCCCCTCCTGGACCTGCATGTCGTCTCCGGGGTCACGTGTCTGGTCCT CCCCAAGTACCAGGCCGA CCTGTATACCTATCTGAGTAGGCGCCTGAACCCGCTGGGACGCCCGCAGATCGCAGCGGT CTCCCGGCAGCTCCTAAG C GC C GT T GAC T AC AT T C AC C G C C AG GG C AT TAT C CAC C G C GAC AT T AAGAC C GAAAAT AT T T T TAT T AAC AC C C C C GA GGACATTTGCCTGGGGGACTTTGGTGCCGCGTGCTTCGTGCAGGGTTCCCGATCAAGCCC CTTCCCCTACGGAATCGC CGGAACCATCGACACCAACGCCCCCGAGGTCCTGGCCGGGGATCCGTATACCACCACCGT CGACATTTGGAGCGCCGG TCTGGTGATCTTCGAGACTGCCGTCCACAACGCGTCCTTGTTCTCGGCCCCCCGCGGCCC CAAAAGGGGCCCGTGCGA CAGTCAGATCACCCGCATCATCCGACAGGCCCAGGTCCACGTTGACGAGTTTTCCCCGCA TCCAGAATCGCGCCTCAC CTCGCGCTACCGCTCCCGCGCGGCCGGGAACAATCGCCCGCCGTACACCCGACCGGCCTG GACCCGCTACTACAAGAT GGACATAGACGTCGAATATCTGGTTTGCAAAGCCCTCACCTTCGACGGCGCGCTTCGCCC CAGCGCCGCAGAGCTGCT TTGTTTGCCGCTGTTTCAACAGAAATGACCGCCCCCAGGGGGCGGTGCTGTTTGCGGGTT GGCACAAAAAGACCCCGA CCCGCGTCTGTGGTGTTTTTGGCATCATGTCGCCGGGCGCCATGCGTGCCGTTGTTCCCA TTATCCCATTCCTTTTGG TTCTTGTCGGTGTATCGGGGGTTCCCACCAACGTCTCCTCCACCACCCAACCCCAACTCC AGACCACCGGTCGTCCCT CGCATGAAGCCCCCAACATGACCCAGACCGGCACCACCGACTCTCCCACCGCCATCAGCC TTACCACGCCCGACCACA CACCCCCCATGCCAAGTATCGGACTGGAGGAGGAGGAAGAGGAGGAGGGGGCCGGGGACG GCGAACATCTTGAGGGGG GAGATGGGACCCGTGACACCCTACCCCAGTCCCCGGGCCCAGCCTTCCCGTTGGCTGAGG ACGTCGAGAAGGACAAAC CCAACCGTCCCGTAGTCCCATCCCCCGATCCCAACAACTCCCCCGCGCGCCCCGAGACCA GTCGCCCGAAGACACCCC CCACCATTATCGGGCCGCTGGCAACTCGCCCCACGACCCGACTCACCTCAAAGGGACGAC CCTTGGTTCCGACGCCTC AACATACCCCGCTGTTCTCGTTCCTCACTGCCTCCCCCGCCCTGGACACCCTCTTCGTCG TCAGCACCGTCATCCACA CCTTATCGTTTTTGTGTATTGGTGCGATGGCGACACACCTGTGTGGCGGTTGGTCCAGAC GCGGGCGACGCACACACC CTAGCGTGCGTTACGTGTGCCTGCCGTCCGAACGCGGGTAGGGTATGGGGCGGGGGATGG GGAGAGCCCACACGCGGA AAGCAAGAACAATAAAGGCGGTGGTATCTAGTTGATATGCATCTCTGGGTGTTTTTGGGG TGTGGCGGACGCGGGGCG GTCATTGGACGGGGTGCAGTTAAATACATGCCCGGGACCCATGAAGCATGCGCGACTTCC GGGCCTCGGAACCCACCC GAAACGGCCAACGGACGTCTGAGCCAGGCCTGGCTATCCGGAGAAACAGCACACGACTTG GCGTTCTGTGTGTCGCGA TGTCTCTGCGCGCAGTCTGGCATCTGGGGCTTTTGGGAAGCCTCGTGGGGGCTGTTCTTG CCGCCACCCATCGGGGAC CTGCGGCCAACACAACGGACCCCTTAACACACGCCCCAGTGTCCCCTCACCCCAGCCCCC TGGGGGGCTTTGCCGTCC CCCTCGTAGTCGGTGGGCTGTGCGCCGTAGTCCTGGGGGCGGCGTGTCTGTTTGAGCTCC TGCGTCGTACGTGCCGCG GGTGGGGGCGTTACCATCCCTACATGGACCCAGTTGTCGTATAATTCCCCCCCCCCCCCC CTTCTCCGCATGGGTGAT GTCGGGTCCAAACTCCCGACACCACCAGCTGGCATGGTATAAATCACCGGTGCGCCCCCC AAACCATGTCCGGCAGGG GGATGGGGGGGCGAATGCGGAGGGCACCCAACAACACCGGGCTAACCAGGAAATCCGTGG CCCCGGCCCCCAATAAAG ATCGCGGTAGCCCGGCCGTGTGACACTATCGTCCATACCGACCACACCGACGAATCCCCT AAGGGGGAGGGGCCATTT TACGAGGAGGAGGGGTATAACAAAGTCTGTCTTTAAAAAGCAGGGGTTAGGGAGTTGTTC GGTCATAAGCTTCAGCGC GAACGACCAACTACCCCGATCATCAGTTATCCTTAAGGTCTCTTTTGTGTGGTGCGTTCC GGTATGGGGGGGGCTGCC GCCAGGTTGGGGGCCGTGATTTTGTTTGTCGTCATAGTGGGCCTCCATGGGGTCCGCGGC AAATATGCCTTGGCGGAT GCCTCTCTCAAGATGGCCGACCCCAATCGCTTTCGCGGCAAAGACCTTCCGGTCCTGGAC CAGCTGACCGACCCTCCG GGGGTCCGGCGCGTGTACCACATCCAGGCGGGCCTACCGGACCCGTTCCAGCCCCCCAGC CTCCCGATCACGGTTTAC TACGCCGTGTTGGAGCGCGCCTGCCGCAGCGTGCTCCTAAACGCACCGTCGGAGGCCCCC CAGATTGTCCGCGGGGCC TCCGAAGACGTCCGGAAACAACCCTACAACCTGACCATCGCTTGGTTTCGGATGGGAGGC AACTGTGCTATCCCCATC ACGGTCATGGAGTACACCGAATGCTCCTACAACAAGTCTCTGGGGGCCTGTCCCATCCGA ACGCAGCCCCGCTGGAAC TACTATGACAGCTTCAGCGCCGTCAGCGAGGATAACCTGGGGTTCCTGATGCACGCCCCC GCGTTTGAGACCGCCGGC ACGTACCTGCGGCTCGTGAAGATAAACGACTGGACGGAGATTACACAGTTTATCCTGGAG CACCGAGCCAAGGGCTCC TGTAAGTACGCCCTCCCGCTGCGCATCCCCCCGTCAGCCTGCCTGTCCCCCCAGGCCTAC CAGCAGGGGGTGACGGTG GACAGCATCGGGATGCTGCCCCGCTTCATCCCCGAGAACCAGCGCACCGTCGCCGTATAC AGCTTGAAGATCGCCGGG TGGCACGGGCCCAAGGCCCCATACACGAGCACCCTGCTGCCCCCGGAGCTGTCCGAGACC CCCAACGCCACGCAGCCA GAACTCGCCCCGGAAGACCCCGAGGATTCGGCCCTCTTGGAGGACCCCGTGGGGACGGTG GCGCCGCAAATCCCACCA AACTGGCACATACCGTCGATCCAGGACGCCGCGACGCCTTACCATCCCCCGGCCACCCCG AACAACATGGGCCTGATC GCCGGCGCGGTGGGCGGCAGTCTCCTGGCAGCCCTGGTCATTTGCGGAATTGTGTACTGG ATGCGCCGCCGCACTCAA AAAGCCCCAAAGCGCATACGCCTCCCCCACATCCGGGAAGACGACCAGCCGTCCTCGCAC CAGCCCTTGTTTTACTAG ATACCCCCCCTTAATGGGTGCGGGGGGGTCAGGTCTGCGGGGTTGGGATGGGACCTTAAC TCCATATAAAGCGAGTCT GGAAGGGGGGAAAGGCGGACAGTCGATAAGTCGGTAGCGGGGGACGCGCACCTGTTCCGC CTGTCGCACCCACAGCTT TTTTTGCGAACCGTCCCGTTCCGGGATGCCGTGCCGCCCGTTGCAGGGCCTGGTGCTCGT GGGCCTCTGGGTCTGTGC CACCAGCCTGGTTGTCCGTGGCCCCACGGTCAGTCTGGTATCAAACTCATTTGTGGACGC CGGGGCCTTGGGGCCCGA CGGCGTAGTGGAGGAAGACCTGCTTATTCTCGGGGAGCTTCGCTTTGTGGGGGACCAGGT CCCCCACACCACCTACTA CGATGGGGTCGTAGAGCTGTGGCACTACCCCATGGGACACAAATGCCCACGGGTCGTGCA TGTCGTCACGGTGACCGC GTGCCCACGTCGCCCCGCCGTGGCTTTCGCCCTGTGTCGCGCGACCGACAGCACTCACAG CCCCGCATATCCCACCCT GGAGCTGAATCTGGCCCAACAGCCGCTTTTGCGGGTCCGGAGGGCGACGCGTGACTATGC CGGGGTGTACGTGTTACG CGTATGGGTCGGGGACGCACCAAACGCCAGCCTGTTTGTCCTGGGGATGGCCATAGCCGC CGAAGGGACTCTGGCGTA CAACGGCTCGGCCCATGGCTCCTGCGACCCGAAACTGCTTCCGTATTCGGCCCCGCGTCT GGCCCCGGCGAGCGTATA CCAACCCGCCCCTAACCCGGCCTCCACCCCCTCGACCACCACCTCCACCCCCTCGACCAC CATCCCCGCTCCCTCGAC CACCATCCCCGCTCCCCAAGCATCGACCACACCCTTCCCCACGGGAGACCCAAAACCCCA ACCTCACGGGGTCAACCA CGAACCCCCATCGAATGCCACGCGAGCGACCCGCGACTCGCGATACGCGCTAACGGTGAC CCAGATAATCCAGATAGC CATCCCCGCGTCCATTATAGCCCTGGTGTTTCTGGGGAGCTGTATTTGCTTTATACACAG ATGTCAACGCCGCTACCG ACGCTCCCGCCGCCCGATTTACAACCCCCAGATACCCACTGGCATCTCATGCGCGGTGAA CGAAGCGGCCATGGCCCG CCTCGGAGCCGAGCTCAAATCGCATCCGAGCACCCCCCCCAAATCCCGGCGCCGGTCGTC ACGCACACCAATGCCCTC CCTGACGGCCATCGCCGAAGAGTCGGAGCCCGCGGGGGCGGCTGGGCTTCCGACGCCCCC CGTGGACCCCACGACATC CACCCCAACGCCTCCCCTGTTGGTATAGGTCCACGGCCACTGGCCGGGGGCACCACATAA CCGACCGCAGTCACTGAG TTGGGAATAAACCGGTATTATTTACCTATATACGTGTATGTCCATTTCTTCCCCCCCCCC CCGGAAACCAAAGAAGGA AACAAAGAATGGATGGGAGGAGTTCAGGAAACCGGGGAGAGGGCCCGCGGCGCATTTAAG GCGTTGTTGTGTTGACTT TGGCTCTTCTGGCGGGTTGGTGCGGTGCTGTTTGTTGGGCTCCCATTTTACCCGAAGATC GGCTGCTATCCCCGGGAC ATGGATCGCGGGGCGGTGGTGGGGTTTCTTCTCGGTGTTTGTGTTGTATCGTGCTTGGCG GGAACGCCCAAAACGTCC TGGAGACGGGTGAGTGTCGGCGAGGACGTTTCGTTGCTTCCAGCTCCGGGGCCTACGGGG CGCGGCCCGACCCAGAAA CTACTATGGGCCGTGGAACCCCTGGATGGGTGCGGCCCCTTACACCCGTCGTGGGTCTCG CTGATGCCCCCCAAGCAG GTGCCCGAGACGGTCGTGGATGCGGCGTGCATGCGCGCTCCGGTCCCGCTGGCGATGGCG TACGCCCCCCCGGCCCCA TCTGCGACCGGGGGTCTACGGACGGACTTCGTGTGGCAGGAGCGCGCGGCCGTGGTTAAC CGGAGTCTGGTTATTTAC GGGGTCCGAGAGACGGACAGCGGCCTGTATACCCTGTCTGTGGGCGACATAAAGGACCCG GCTCGCCAAGTGGCCTCG GTGGTCCTGGTGGTGCAACCGGCCCCAGTTCCGACCCCACCCCCGACCCCAGCCGATTAC GACGAGGATGACAATGAC GAGGGCGAGGACGAAAGTCTAGCCGGCACTCCCGCCAGCGGGACCCCCCGGCTCCCGCCT CCCCCCGCCCCCCCGAGG TCTTGGCCCAGCGCCCCCGAAGTCTCACACGTGCGTGGGGTGACCGTGCGTATGGAGACT CCGGAAGCTATCCTGTTT TCCCCCGGGGAGGCGTTTAGCACGAACGTCTCCATCCATGCCATCGCCCACGACGACCAG ACCTACACCATGGACGTC GTCTGGTTGAGGTTCGACGTGCCGACCTCGTGTGCCGAGATGCGAATATACGAATCGTGT CTGTATCACCCGCAGCTC CCAGAGTGTCTGTCCCCGGCCGACGCTCCGTGCGCCGCGAGTACGTGGACGTCTCGCCTG GCCGTCCGCAGCTACGCG GGGTGTTCCAGAACAAACCCCCCGCCGCGCTGTTCGGCCGAGGCTCACATGGAGCCCTTC CCGGGGCTGGCGTGGCAG GCGGCCTCCGTCAATCTGGAGTTCCGGGACGCGTCCCCACAACACTCCGGCCTGTATCTG TGCGTGGTGTACGTCAAC GACCATATTCACGCATGGGGCCACATTACCATCAGCACCGCGGCGCAGTACCGGAACGCG GTGGTGGAACAGCCCCTC CCACAGCGCGGCGCGGATTTGGCCGAGCCCACCCACCCGCACGTCGGGGCCCCTCCCCAC GCGCCCCCAACCCACGGC GCCCTGCGGTTAGGGGCGGTGATGGGGGCCGCCCTGCTGCTGTCTGCGCTGGGGTTGTCG GTGTGGGCGTGTATGACC TGTTGGCGCAGGCGTGCCTGGCGGGCGGTTAAAAGCAGGGCCTCGGGTAAGGGGCCCACG TACATTCGCGTGGCCGAC AGCGAGCTGTACGCGGACTGGAGCTCGGACAGCGAGGGAGAACGCGACCAGGTCCCGTGG CTGGCCCCCCCGGAGAGA CCCGACTCTCCCTCCACCAATGGATCCGGCTTTGAGATCTTATCACCAACGGCTCCGTCT GTATACCCCCGTAGCGAT GGGCATCAATCTCGCCGCCAGCTCACAACCTTTGGATCCGGAAGGCCCGATCGCCGTTAC TCCCAGGCCTCCGATTCG TCCGTCTTCTGGTAAGGCGCCCCATCCCGAGGCCCCACGTCGGTCGCCGAACTGGGCGAC CGCCGGCGAGGTGGACGT CGGAGACGAGCTAATCGCGATTTCCGACGAACGCGGACCCCCCCGACATGACCGCCCGCC CCTCGCCACGTCGACCGC GCCCTCGCCACACCCGCGACCCCCGGGCTACACGGCCGTTGTCTCCCCGATGGCCCTCCA GGCTGTCGACGCCCCCTC CCTGTTTGTCGCCTGGCTGGCCGCTCGGTGGCTCCGGGGGGCTTCCGGCCTGGGGGCCGT CCTGTGTGGGATTGCGTG GTATGTGACGTCAATTGCCCGAGGCGCATAAAGGGCCGGTGGTCCGCCTAGCCGCAGCAA ATTAAAAATCGTGAGTCA CTGCGACCGCAACTTCCCACCCGGAGCTTTCTTCCGGCCTCGATGACGTCCCGGCTCTCC GATCCCAACTCCTCAGCG CGATCCGACATGTCCGTGCCGCTTTATCCCACGGCCTCGCCAGTTTCGGTCGAAGCCTAC TACTCGGAAAGCGAAGAC GAGGCGGCCAACGACTTCCTCGTACGCATGGGCCGCCAACAGTCGGTATTAAGGCGTCGA CGCAGACGCACCCGCTGC GTCGGCATGGTGATCGCCTGTCTCCTCGTGGCCGTTCTGTCGGGCGGATTTGGGGCGCTC CTGATGTGGCTGCTCCGC TAAAAGACCGCATCGACACGCGCGTCCTTCTTGTCGTCTCTCTTCCCCCCCATCACCCCG CAATTTGCACCCAGCCTT TAACTACATTAAATTGGGTTCGATTGGCAATGTTGTCTCCCGGTTGATTTTTGGGTGGGT GGGGAGTGGGTGGGTGGG GAGTGGGTGGGTGGGGAGTGGGTGGGTGGGGAGTGGGTGGGTGGGGAGTGGGTGGGTGGG GAGTGGGTGGGTGGGGAG TGGGTGGGTGGGGAGTGGGTGGGTGGGGAGTGGGTGGGTGGGGAGTGGCAAGGAAGAAAC AAGCCCGACCACCAGACA GAAAATGTAACCATACCCAAACCGACTCTGGGGGCTGTTTGTGGGGTCGGAACCATAGGA TGAACAAACCACCCCGTA CCTCCCGCACCCTTGGGTGCGGTGGCTCATCGGCATCTGTCCGGTATGGGTTGTTCCCCA CCCACTTGCGTTCGGACG TCTTAGAATCATGGCGGTTTTCTATGCCGACATCGGTTTTCTCCCCCGCAATAAGACACG ATGCGATAAAATCTGTTT GTGAAATTTATTAAGGGTACAAATTGCCCTAGCACAGGGGTGGGGTTAGGGCCGGGTCCC CACACCCAAACGCACCAA ACAGATGCAGGCAGTGGGTCGAGTACAGCCCCGCGTACGAACACGTCGATGCGTGTGTCA GACAGCACCAGAAAGCAC AGGCCATCAACAGGTCGTGCATATGTCGGTGGGTTTGGACGCGGGGGGCCATGGTGGTGA TAAAGTTAATGGCCGCCG TCCGCCAGGGCCACAGGGGCGACGTCTCTTGGTTGGCCCGGAGCCACTGGGTGTGGACCA GCCGCGCGTGGCGGCCCA ACATGGCCCCTGTAGCCGGGGGCGGGGGATCGCGCACGTTTGCAGCGCACATGCGAGACA CCTCGACCACGGTTCGGA AGAAGGCCCGGTGGTCCGCGGGCAACATCACCAGGTGCGCAAGCGCCCGGGCGTCCAGAG GGTAGAGCCCTGAGTCAT CCGAGGTTGGCTCATCGCCCGGGTCATGCCGCAAGTGCGTGTGGGTTGGGCTTCCGGTGG GCGGGACGCGAACCGCGG TGTGGAGCCCTACGCGGGCCCGAGCGTACGCTCCATCTTGTGGGGAGAAGGGGTCTGGGC TCGCCAGGGGGGCATACT TGCCCGGGCTATACAGACCCGCGAGCCGTACGTGGTTCGCGGGGGGTGCGTGGGGTCCGG GGCTCCCGGGGAGGCCGG GGCTCCCGGGGAGGCCGGGGCTCCCACCGGGGTTGTCGTGGATCCCTGGGGTCACGCGGT ACCCTGGGGTCTCTGGGA GCTCGCGGTACTCTGGGTTCCCTAGGTTCTCGGGGTGGTCGCAGAACCCGGGGCTCCCGG GGAACACGCGGTGTCCTG GGGATTGTTGGCGGTCGGACGGCTTCAGATGGCTTCGAGATCGTAGTGTCCGCACCGACT CGTAGTAGACCCGAATCT CCACATTGCCCCGCCGCTTGATCATTATCACCCCGTTGCGGGGGTCCGGAGATCATGCGC GGGTGTCCTCGAGGTGCG TGAACACCTCTGGGGTGCATGCCGGCGGACGGCACGCCTTTTAAGTAAACATCTGGGTCG CCCGGCCCAACTGGGGCC GGGGGTTGGGTCTGGCTCATCTCGAGAGCCACGGGGGGAACCACCCTCCGCCCAGAAACT TGGGCGATGGTCGTACCC GGGACTCAACGGGTTACCGGATTACGGGGACTGTCGGTCACGGTCCCGCCGGTTCTTCGA TGTGCCACACCCAAGGAT GCGTTGGGGGCGATTTTGGGCAGCAGCCCGGGAGAGCGCAGCAGAGGACGCTCCGGGTCG TGCATGGCGGTTTTGGCT GCCTCCCGGTCCTCACGCCCCCTTTTATTGATCTCATCGCGTACGTCGGCGTACGTCCTG GGCCCAACCCGCATGTTG TCCAGGAAGGTGTCCGCCATTTCCAGGGCCCACGACATGCTCCCCCCCGACGAGCAGGAA GCGGTCCACGCAACGGTC GCCGCCGGTCGCCTCGACGAGGACGTTCCTCCTGCGGGAAGGCACGAACGCGGGTGAGCC CCCTCCTCCGCCCCCGTG TCCCCCCTCCTCCGCCCCCGCGTCCCCCCTCCTCCGCCCCCGCGTCCCCCCTCCTCCGCC CCCGCGTCCCCCCTCCTC CGCCCCCGCGTCCCCCCTCCTCCGCCCCCGCGTCCCCCCTCCTCCGCCCCCGTGTCCCCC CTCCTCCGCCCACCCAAG GTGCTTACCCGTGCACAAAGGCGGACCGGTGGGTTTCTGTCGTCGGAGGCCCCCGGGGTG CGTCCCCTGTGTTTCGTG GGTGGGGTGGGTGGGTCTTTCCGCGTGTCCCTTTCCGATGCGATCCCGATCCCGAGCCGG GGCGTCGCGATGCCGACG CCGTCCGCTCCGACGGCCCTCTGCGAGTCCCGCTCCCGGTCCGCGTGCTCCGCAGCCGCT CCCGTCGTTCGTGGCCGG CGCCGTCTGCGGGCGTCGGTCGCGCCGGGCCTTTATGTGCGCCGGAGAGACCCGCCCCCC GCCGCCCGGGCCCGCCCC CGGGGCCGGCGCGGAGTCGGGCACGGCGCCAGTGCTCGCACTTCGCCCTAATAATATATA TATATTGGGACGAAGTGC GAACGCTTCGCGTTCTCACTTCTTTTACCCGGCGGCCCCGCCCCCTTGGGGCGGTCCCGC CCGCCGGCCAATGGGGGG GCGGCAAGGCGGGCGGCCCTTGGGCCGCCCGCCGTCCCGTTGGTCCCAACGTCCGGCGGG CGGGACCGGGGGCCCGGG GACGGCCAACGGGCGCGCGGGGCTCGTATCTCATTACCGCCGAACCGGGAAGTCGGGGCC CGGGCCCCGCCCCCGGCC CGTTCCTCGTTAGCATGCGGAACGGAAGCGGAAACCACCGGATCGGGCGGTAATGAGATG CCATGCGGGGCGGGGCGC GGGCCCACCCGCCCTCGCGCCCCGCCCATGGCAGATGGCGCGGATGGGCGGGGCCGGGGG TTCGACCAACGGGCCGCG GCCACGGGCCCCCGGCGTGCCGGCGTCGGGGCGGGGTCGTGCATAATGGAATTCCGTTCG GGGCGGGCCCGCCTGGGG GGCGGGGGGCCGGCGGCCTCCGCTGCTCCTCCTTCCCGCCGGCCCCTGGGACTATATGAG CCCGAGGACGCCCCGATC GTCCACACGGAGCGCGGCTGCCGACACGGATCCACGACCCGACGCGGGACCGCCAGAGAC AGACCGTCAGACGCTCGC CGCGCCGGGACGCCGATACGCGGACGAAGCGCGGGAGGGGGATCGGCCGTCCCTGTCCTT TTTCCCACCCAAGCATCG ACCGGTCCGCGCTAGTTCCGCGTCGACGGCGGGGGTCGTCGGGGTCCGTGGGTCTCGCCC CCTCCCCATCGAGAGTCC GTAGGTGACCTACCGTGCTACGTCCGCCGTCGCAGCCGTATCCCCGGAGGATCGCCCCGC ATCGGCGATGGCGTCGGA GAACAAGCAGCGCCCCGGCTCCCCGGGCCCCACCGACGGGCCGCCGCCCACCCCGAGCCC AGACCGCGACGAGCGGGG GGCCCTCGGGTGGGGCGCGGAGACGGAGGAGGGCGGGGACGACCCCGACCACGACCCCGA CCACCCCCACGACCTCGA CGACGCCCGGCGGGACGGGAGGGCCCCCGCGGCGGGCACCGACGCCGGCGAGGACGCCGG GGACGCCGTCTCGCCGCG ACAGCTGGCCCTGCTGGCCTCCATGGTAGAGGAGGCCGTCCGGACGATCCCGACGCCCGA CCCCGCGGCCTCGCCGCC CCGGACCCCCGCCTTTCGAGCCGACGACGATGACGGGGACGAGTACGACGACGCAGCCGA CGCCGCCGGCGACCGGGC CCCGGCCCGGGGCCGCGCACGGGAGGCCCCGCTACGCGGCGCGTATCCGGACCCCACGGA CCGCCTGTCGCCGCGCCC GCCGGCCCAGCCGCCGCGGAGACGTCGTCACGGCCGGCGGCGGCCATCGGCGTCATCGAC CTCGTCGGACTCCGGGTC CTCGTCCTCGTCGTCCGCATCCTCTTCGTCCTCGTCGTCCGACGAGGACGAGGACGACGA CGGCAACGACGCGGCCGA CCGCGCACGCGAGGCGCGGGCCGTCGGGCGGGGTCCGTCGAGCGCGGCGCCGGAAGCCCC CGGGCGGACGCCGCCCCC GCCCGGGCCACCCCCCCTCTCCGAGGCCGCGCCCAAGCCCCGGGCGGCGGCGAGGACCCC CGCGGCCTCCGCGGGCCG CATCGAGCGCCGCCGGGCCCGCGCGGCGGTGGCCGGCCGCGACGCCACGGGCCGCTTCAC GGCCGGGCAGCCCCGGCG GGTCGAGCTGGACGCCGACGCGGCCTCCGGCGCCTTCTACGCGCGCTATCGCGACGGGTA CGTCAGCGGGGAGCCGTG GCCCGGCGCCGGGCCCCCGCCCCCGGGGCGGGTGCTGTACGGCGGCCTGGGCGACAGCCG CCCGGGCCTCTGGGGGGC GCCCGAGGCGGAGGAGGCGCGACGCCGGTTCGAGGCCTCGGGCGCCCCGGCGGCCGTGTG GGCGCCCGAGCTGGGCGA CGCCGCGCAGCAGTACGCCCTGATCACGCGGCTGCTGTACACCCCGGACGCGGAGGCCAT GGGGTGGCTCCAGAACCC GCGCGTGGTCCCCGGGGACGTGGCGCTGGACCAGGCCTGCTTCCGGATCTCGGGCGCCGC GCGCAACAGCAGCTCCTT CATCACCGGCAGCGTGGCGCGGGCCGTGCCCCACCTGGGCTACGCCATGGCGGCCGGCCG CTTCGGCTGGGGCCTGGC GCACGCGGCGGCCGCCGTGGCCATGAGCCGCCGATACGACCGCGCGCAGAAGGGCTTCCT GCTGACCAGCCTGCGCCG CGCCTACGCGCCCCTGTTGGCGCGCGAGAACGCGGCGCTGACGGGGGCCGCGGGGAGCCC CGGCGCCGGCGCAGATGA CGAGGGGGTCGCCGCCGCCGCCGCCGCCGCACCGGGCGAGCGCGCGGTGCCCGCCGGGTA CGGCGCCGCGGGGATCCT CGCCGCCCTGGGGCGGCTGTCCGCCGCGCCCGCCTCCCCCGCGGGGGGCGACGACCCCGA CGCCGCCCGCCACGCCGA CGCCGACGACGACGCCGGGCGCCGCGCCCAGGCCGGCCGCGTGGCCGTGGAGTGCCTGGC CGCCTGCCGCGGGATCCT GGAGGCGCTGGCCGAGGGCTTCGACGGCGACCTGGCGGCCGTCCCGGGGCTGGCCGGGGC CCGGCCCGCCAGCCCCCC GCGGCCGGAGGGACCCGCGGGCCCCGCTTCCCCGCCGCCGCCGCACGCCGACGCGCCCCG CCTGCGCGCGTGGCTGCG CGAGCTGCGGTTCGTGCGCGACGCGCTGGTGCTCATGCGCCTGCGCGGGGACCTGCGCGT GGCCGGCGGCAGCGAGGC CGCCGTGGCCGCCGTGCGCGCCGTGAGCCTGGTCGCCGGGGCCCTGGGCCCCGCGCTGCC GCGGGACCCGCGCCTGCC GAGCTCCGCGGCCGCCGCCGCCGCGGACCTGCTGTTTGAGAACCAGAGCCTGCGCCCCCT GCTGGCGGCGGCGGCCAG CGCACCGGACGCCGCCGACGCGCTGGCGGCCGCCGCCGCCTCCGCCGCGCCGCGGGAGGG GCGCAAGCGCAAGAGTCC CGGCCCGGCCCGGCCGCCCGGAGGCGGCGGCCCGCGACCCCCGAAGACGAAGAAGAGCGG CGCGGACGCCCCCGGCTC GGACGCCCGCGCCCCCCTCCCCGCGCCCGCGCCCCCCTCCACGCCCCCGGGGCCCGAGCC CGCCCCCGCCCAGCCCGC GGCGCCCCGGGCCGCCGCGGCGCAGGCCCGCCCGCGCCCCGTGGCCGTGTCGCGCCGGCC CGCCGAGGGCCCCGACCC CCTGGGCGGCTGGCGGCGGCAGCCCCCGGGGCCCAGCCACACGGCGGCGCCCGCGGCCGC CGCCCTGGAGGCCTACTG CTCCCCGCGCGCCGTGGCCGAGCTCACGGACCACCCGCTGTTCCCCGTCCCCTGGCGACC GGCCCTCATGTTTGACCC GCGGGCCCTGGCCTCGATCGCCGCGCGGTGCGCCGGGCCCGCCCCCGCCGCCCAGGCCGC GTGCGGCGGCGGCGACGA CGACGATAACCCCCACCCCCACGGGGCCGCCGGGGGCCGCCTCTTTGGCCCCCTGCGCGC CTCGGGCCCGCTGCGCCG CATGGCGGCCTGGATGCGCCAGATCCCCGACCCCGAGGACGTGCGCGTGGTGGTGCTGTA CTCGCCGCTGCCGGGCGA GGACCTGGCCGGCGGCGGGGCCTCGGGGGGGCCGCCGGAGTGGTCCGCCGAGCGCGGCGG GCTGTCCTGCCTGCTGGC GGCCCTGGCCAACCGGCTGTGCGGGCCGGACACGGCCGCCTGGGCGGGCAACTGGACCGG CGCCCCCGACGTGTCGGC GCTGGGCGCGCAGGGCGTGCTGCTGCTGTCCACGCGGGACCTGGCCTTCGCCGGGGCCGT GGAGTTTCTGGGGCTGCT CGCCAGCGCCGGCGACCGGCGGCTCATCGTGGTCAACACCGTGCGCGCCTGCGACTGGCC CGCCGACGGGCCCGCGGT GTCGCGGCAGCACGCCTACCTGGCGTGCGACCTGCTGCCCGCCGTGCAGTGCGCCGTGCG CTGGCCGGCGGCGCGGGA CCTGCGCCGCACGGTGCTGGCCCCGGGCCGCGTGTTCGGCCCGGGGGTCTTCGCGCGCGT GGAGGCCGCGCACGCGCG CCTGTACCCCGACGCGCCGCCGCTGCGCCTGTGCCGCGGCGGCAACGTGCGCTACCGCGT GCGCACGCGCTTCGGCCC GGACACGCCGGTGCCCATGTCCCCGCGCGAGTACCGCCGGGCCGTGCTGCCGGCGCTGGA CGGCCGGGCGGCGGCCTC GGGGACCACCGACGCCATGGCGCCCGGCGCGCCGGACTTCTGCGAGGAGGAGGCCCACTC GCACCGCGCCTGCGCGCG CTGGGGCCTGGGCGCGCCGCTGCGGCCCGTGTACGTGGCGCTGGGGCGCGAGGCGGTGCG CGCCGGCCCGGCCCGGTG GCGCGGGCCGCGGAGGGACTTTTGCGCCCGCGCCCTGCTGGAGCCCGACGACGACGCCCC CCCGCTGGTGCTGCGCGG CGACGACGACGGCCCGGGGGCCCTGCCGCCGGCGTTGCCCGGGATTCGCTGGGCCTCGGC CACGGGCCGCAGCGGCAC CGTGCTGGCGGCGGCGGGGGCCGTGGAGGTGCTGGGGGCGGAGGCGGGCTTGGCCACGCC CCCGCGACGGGAAGTTGT GGACTGGGAAGGCGCCTGGGACGACGACGACGGCGGCGCGTTCGAGGGGGACGGGGTGCT GTAACGGGCCGGGACGGG GCGGGGCGCTTGCGAAACCCGAAGACACAATAAACGGCAACAACCTGATTTAGTTTTGCA GTAGCGTTGTTTATTTGA GGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGA GGGGGCGAGGGGCGGGAG GGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGG GGCGGGAGGGGGCGAGGG GCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGG GGCGAGGGGCGGGAGGGG GCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGCGGGAGGGGGCGAGGGGC GGGAGGGGGCGAGGGGCG GGAGGGGGCGAGGGGCGGTGGTGGTGCGCGGGCGCCCCCGGAGGGTTTGGATCTCTGACC TGAGATTGGCGGCACTGA GGTAGAGATGCCCGAACCCCCCCGAGGGAGCGCGGGACGCGCCGGGGAGGGCTGGGGCCG GGGAGGGCTGGGGCCGGG GAGGGCTGGGGCCGGGGAGGGCTGGGGCCGGGGAGGGCTGGGGCCGGGGAGGGCTGGGGC TGGGGAGGGCTGGGGCTG GGGAGGGCTGGGGCTGGTGGTGTGTGACAGGAGCGGCGTGTTGCGCTGGGGGACGTCTGG AGGAGCGGGGGGTGCGCG GTGACGTGTGGATGAGGAACAGGAGTTGTTGCGCGGTGAGTTGTCGCTGTGAGTTGTGTT GGTGGGCAGGTGTGGTGG ATGACGTGACGTGTGACGTGTGGATGAGGCGTGCTCTGTTGGTTTCACCTGTGGCAGCCC GGGCCCCCCGCGGGCGGG GCGGCGCGCAAAAAAGGCGGGCGGCGGTCCGGGCGGCGTGCGCGCGCGCGGCGGGCGTTG GGGGCGGGGCCGCGGGAG CGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGRRGGGAGGAGCGGGGGGAGGAG CGGGGGGAGGAGCGGGGG GAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGG GAGGAGCGGGGGGAGGAG CGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAG CGAAAACGGGCCCCCCCC SAAACACACCCCCCGGGGGTCGCGCGCGGCCCTTTAAAGCGGTGGCGGCGCAGCCCGGGC CCCCCGCGGGCGCGCGCG CGCGCAAAAAAGGCGGGCGGCGGTCCGGGCGGCGTGCGCGCGCGCGGCGGGCGTGGGGGG CGGGGCCGCGGGAGCGGG GGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGG GGGAGGAGCGGGGGGAGG AGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGG AGCGGGGGGAGGAGCGGG GGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGGGGGGAGGAGCGAA AACGGGCCCCCCCCAAAA CACACCCCCCGGGGGTCGCGCGCGGCCCTTTAAAGCGGGCGGCGGCAGCCCGGGCCCCCC GCGGCCGAGACGAGCGAG TTAGACAGGCAAGCACTACTCGCCTCTGCACGCACATGCTTGCCTGTCAAACTCTACCAC CCCGGCACGCTCTCTGTC TCCATGGCCCGCCGCCGCCGCCATCGCGGCCCCCGCCGCCCCCGGCCGCCCGGGCCCACG GGCGCCGTCCCAACCGCA CAGTCCCAGGTAACCCTTGTTCCGCTTCCCGGTATGGTAATTAGAAACTCATTAATGGGC GGCCCCGGCCGCCCTTCC CGCTTCCGGCAATTCCCGCGGCCCTTAATGGGCAACCCCGGTATTCCCCGCCTCCCGCGC CGCGCGTAACCACTCCCC TGGGGTTCCGGGTTATGCTAATTGCTTTTTTGGCGGAACACACGGCCCCTCGCGCATTGG CCCGCGGGTCGCTCAATG AACCCGCATTGGTCCCCTGGGGTTCCGGGTATGGTAATGAGTTTCTTCGGGAAGGCGGGA AGCCCCGGGGCACCGACG CAGGCCAAGCCCCTGTTGCGTCGGTGGGAGGGGCATGCTAATGGGGTTCTTTGGGGGACA CCGGGTTGGTCCCCCAAA TCGGGGGCCGGGCCGTGCATGCTAATGATATTCTTTGGGGGCGCCGGGTTGGTCCCCGGG GACGGGGCCGCCCCGCGG TGGGCCTGCCTCCCCTGGGACGCGCGGCCATTGGGGGAATCGTCACTGCCGCCCCTTTGG GGAGGGGAAAGGCGTGGG GTATAAGTTAGCCCTGGCCCGACAGTCTGGTCGCATTTGCACCTCGGCACTCGGAGCGAG ACGCAGCAGCCAGGCAGA CTCGGGCCGCCCCCTCTCCGCATCACCACAGAAGCCCCGCCTACGTTGCGACCCCCAGGG ACCCTCCGTCCGCGACCC TCCAGCCGCATACGACCCCCATGGAGCCCCGCCCCGGAGCGAGTACCCGCCGGCCTGAGG GCCGCCCCCAGCGCGAGG TGAGGGGCCGGGCGCCATGTCTGGGGCGCCATATTGGGGGGCGCCATATTGGGGGGCGCC ATGTTGGGGGACCCCCGA CCCTTACACTGGAACCGGCCGCCATGTTGGGGGACCCCCACTCATACACGGGAGCCGGGC GCCATGTTGGGGCGCCAT GTTAGGGGGCGTGGAACCCCGTGACACTATATATACAGGGACCGGGGGCGCCATGTTAGG GGGCGCGGAACCCCCTGA CCCTATATATACAGGGACCGGGGTCGCCCTGTTGGGGGTCGCCATGTGACCCCCTGACTT TATATATACAGACCCCCC AACACATACACATGGCCCCTTTGACTCAGACGCAGGGCCCGGGGTCGCCGTGGGACCCCC TGACTCATACACAGAGAC ACGCCCCCACAACAAACACACAAGGACCGGGGTCGCCGTGTTAGGGGGCGTGGTCCCCAC TGACTCATACGCAGGGCC CCCTTACTCACACGCATCTAGGGGGGTGGGGAGGAGCCGCCCGCCATATTTGGGGGACGC CGTGGGACCCCCGACTCC GGTGCGTCTGGAGGGCGGGAGAAGAGGGAAGAAGAGGGGTCGGGATCCAAAGGACGGACC CAGACCACCTTTGGTTGC AGACCCCTTTCTCCCCCCTCTTCCGAGGCCAGCAGGGGGGCAGGACTTTGTGAGGCGGGG GGGGGAGAGGGGGAACTC GTGGGCGCTGATTGACGCGGGAAATCCCCCCATTCTTACCCGCCCCCCTTTTTTCCCCTT AGCCCGCCCCGGATGTCT GGGTGTTTCCCTGCGACCGAGACCTGCCGGACAGCAGCGACTCTGAGGCGGAGACCGAAG TGGGGGGGCGGGGGGACG CCGACCACCATGACGACGACTCCGCCTCCGAGGCGGACAGCACGGACACGGAACTGTTCG AGACGGGGCTGCTGGGGC CGCAGGGCGTGGATGGGGGGGCGGTCTCGGGGGGGAGCCCCCCCCGCGAGGAAGACCCCG GCAGTTGCGGGGGCGCCC CCCCTCGAGAGGACGGGGGGAGCGACGAGGGCGACGTGTGCGCCGTGTGCACGGATGAGA TCGCGCCCCACCTGCGCT GCGACACCTTCCCGTGCATGCACCGCTTCTGCATCCCGTGCATGAAAACCTGGATGCAAT TGCGCAACACCTGCCCGC TGTGCAACGCCAAGCTGGTGTACCTGATAGTGGGCGTGACGCCCAGCGGGTCGTTCAGCA CCATCCCGATCGTGAACG ACCCCCAGACCCGCATGGAGGCCGAGGAGGCCGTCAGGGCGGGCACGGCCGTGGACTTTA TCTGGACGGGCAATCAGC GGTTCGCCCCGCGGTACCTGACCCTGGGGGGGCACACGGTGAGGGCCCTGTCGCCCACCC ACCCTGAGCCCACCACGG ACGAGGATGACGACGACCTGGACGACGGTGAGGCGGGGGGGCGGCGAGGACCCTGGGGGA GGAGGAGGAGGAGGGGGG AGGGAGGAATAGGCGGGCGGGGGAGGAAAGGGAGGGCCTGGGAGGGGGCGTAACCTGATC GCGCCCCCCGTTGTCTCT TGCAGCAGACTACGTACCGCCCGCCCCCCGCCGGACGCCCCGCGCCCCCCCACGCAGAGG CGCCGCCGCGCCCCCCGT GACGGGCGGGGCGTCTCACGCAGCCCCCCAGCCGGCCGCGGCTCGGACAGCGCCCCCCTC GGCGCCCATCGGGCCACA CGGCAGCAGTAACACCAACACCACCACCAACAGCAGCGGCGGCGGCGGCTCCCGCCAGTC GCGAGCCGCGGCGCCGCG GGGGGCGTCTGGCCCCTCCGGGGGGGTTGGGGTTGGGGTTGGGGTTGTTGAAGCGGAGGC GGGGCGGCCGAGGGGCCG GACGGGCCCCCTTGTCAACAGACCCGCCCCCCTTGCAAACAACAGAGACCCCATAGTGAT CAGCGACTCCCCCCCGGC CTCTCCCCACAGGCCCCCCGCGGCGCCCATGCCAGGCTCCGCCCCCCGCCCCGGGCCCAC CGCGTCCTCGGCCGCGTC GGGACCCGCGCGCCCCCGCGCGGCCGTGGCCCCGTGCGTGCGAGCGCCGCCTCCGGGGCC CGGCCCCCGCGCCCCGGC CCCCGGGGCGGAGCCGGCCGCCCGCCCCGCGGACGCGCGCCGTGTGCCCCAGTCGCACTC GTCCCTGGCTCAGGCCGC GAACCAAGAACAGAGTCTGTGCCGGGCGCGTGCGACGGTGGCGCGCGGCTCGGGGGGGCC GGGCGTGGAGGGTGGACA CGGGCCCTCCCGCGGCGCCGCCCCCTCCGGCGCCCCCCCGCTCCCCTCCGCCGCCTCTGT CGAGCAGGAGGCGGCGGT GCGTCCGAGGAAGAGGCGCGGGTCGGGCCAGGAAAACCCCTCCCCCCAGTCCACGCGTCC CCCCCTCGCGCCGGCAGG GGCCAAGAGGGCGGCGACGCACCCCCCCTCCGACTCAGGGCCGGGGGGGCGCGGCCAGGG TGGGCCCGGGACCCCCCT GACGTCCTCGGCGGCCTCCGCCTCTTCCTCCTCTGCCTCTTCCTCCTCGGCCCCGACTCC CGCGGGGGCCGCCTCTTC CGCCGCCGGGGCCGCGTCCTCCTCCGCTTCCGCCTCCTCGGGCGGGGCCGTCGGTGCCCT GGGAGGGAGACAAGAGGA AACCTCCCTCGGCCCCCGCGCTGCTTCTGGGCCGCGGGGGCCGAGGAAGTGTGCCCGGAA GACGCGCCACGCGGAGAC TTCCGGGGCCGCCCCCGCGGGCGGCCTCACGCGCTACCTGCCCATCTCGGGGGTCTCTAG CGTGGTCGCCCTGTCGCC TTACGTGAACAAGACGATCACGGGGGACTGCCTGCCCATCCTGGACATGGAGACGGGGAA CATCGGGGCGTACGTGGT CCTGGTGGACCAGACGGGAAACATGGCGACCCGGCTGCGGGCCGCGGTCCCCGGCTGGAG CCGCCGCACCCTGCTCCC CGAGACCGCGGGTAACCACGTGATGCCCCCCGAGTACCCGACGGCCCCCGCGTCGGAGTG GAACAGCCTCTGGATGAC CCCCGTGGGGAACATGCTGTTCGACCAGGGCACCCTAGTGGGCGCCCTGGACTTCCGCAG CCTGCGGTCTCGGCACCC GTGGTCCGGGGAGCAGGGGGCGTCGACCCGGGACGAGGGAAAACAATAAGGGACGCCCCC CGTGTTTGTGGGGAGGGG GGGGTCGGGCGCTGGGTGGTCTCTGGCCGCGCCCACTACACCAGCCAATCCGTGTCGGGG AGGGGAAAAGTGAAAGAC ACGGGCACCACACACCAGCGGGTCTTTAGTGTTGGCCCTAATAAAAAACTCAGGGGATTT TTGCTGTCTATTGGGAAA TAAAGGTTTACTTTTGTATCTTTTCCCTGTCTGTGTTGGATGGATCTCGGGGGTGCGTGG GAGTGGGGGTGCGTGGGA GTGGGGGTGCGTGGGAGTGGGGGTGCGTGGGAGTGGGGGTGCGTGGGAGTGGGGGTGCGT GGGAGTGGGGGTGCGTGG GAGTGGGGGTGCGTGGGAGTGGGGGTGCGTGGGAGTGGGGGTGCCATGTTGGGCAGGCTC TGGTGTTAACCACAGAGC CGCGGCCCGGGCTGCCTGACCACCGATCCCCGAAAGCATCCTGCCATTGGCATGGAGCCA GAACCACAGTGGGTTGGG TGTGGGTGTTAAGTTTCCGCGAGCGCCTGCCCGCCCGGACTGACCTGGCCTCTGGCCGCC ACAAAGGGCGGGGGGGGT TAACTACACTATAGGGCAACAAAGGACGGGAGGGGTGGCGGGGCGGGACGGGGCGCCCAA AAGGGGGTCGGCCACACC ACAGACGTGGGTGTTGGGGGGTGGGGCGGAGGGGTGGGGGGGGGGGAGACAGAAACAGGA ACATAGTTAGAAAACAAG AATGCGGTGCAGCCAGAGAATCACAGGAGACGAGGGGATGGGCGTGTTGGTTACCAACCC ACACCCAGGCATGCTCGG TGGTATGAAGGAGGGGGGGCGGTGCTTCTTAGAGACCGCCGGGGGACGTGGGGTTGGTGT GCAGAGGCACGCGCACCC GCGCGGCCAGGTGGGCCGGTACCCCATCCCCCCTCCCCCGACCCTTCCCACCCCCGCGTG CCAGAGATCACCCCGGTC CCCCGGCACCCGCCACTCCTCCATATCCTCGCTTTAGGAACAACTTTAGGGGGGGTACAC ACGCGCCGTGCATTTCCT TCCACACCCCCCCTCCCCCGCACTCCCCCCCCCCCGGCAGTAAGACCCAAGCATAGAGAG CCAGGCACAAAAACACAG GCGGGGTGGGACACATGCCTTCTTGGAGTACGTGGGTCATTGGCGTGGGGGGTTACAGCG ACACCGGCCGACCCCCTG GCGGTCTTCCAGCCGGCCCTTAGATAAGGGGGCAGTTGGTGGTCGGACGGGTAAGTAACA GAGTCTGACTAAGGGTGG GAGGGGGGGAAAAGAACGGGCTGGTGTGCTGTAACACGAGCCCACCCGCGAGTGGCGTGG CCGACCTTAGCCTCTGGG GCGCCCCCTGTCGTTTGGGTCCCCCCCCTCTATTGGGGAGAAGCAGGTGTCTAACCTACC TGGAAACGCGGCGTCTTT GTTGAACCACACCGGGGCGCCCTTGACGAGTGGGATAACGGGGGAGGAAGGGAGGGAGGA GGGTACTGGGGGTGAAGA AGGGGGGGGG GAGAAGC GAGAAC AG GAAAG G C GAC G GAG C C C GACAAAAC AC C GAGAAAAAAAAAAC C AC AG C GC AT G CGCCGGGCCGTTGTGGGGCCCCGGGCCGGGGCCCCTTGGGTCCGCCGGGGCCCCGGGCCG GGCCGCCACGGGGGCCGG CCGTTGGCGGTAACCCCGATTGTTTATCTCAGGCCCCGGGCCGGGAACCCGGAAAAGCCT CCGGGGGGCCTTTTTCGC GTCGCGTGCCGGCGAGCGGGCCCGGACGGGGCCCGGACCGCCGCGGTCGGGGGCCCCCTC GTCCCGGGCCGTACGCGG CCTTCGCCCCGTGAGGGGACAGACGAACGAAACATTCCGGCGACGGAACGAAAAACACCC CAGACGGGTTAAAGAAAC AGAAACCGCAACCCCCCCCACCCCCGAAACGGGGAAAACAAAAAACAGACCAGCGGCCGG CCGGCGCTTAGGGGGAGG ATGTCGCCGACGCCCCTTGGCCGCCCCGGCTGCAGGGGGGCCCGGAGAGCCGCGGCACCC GGACGCGCCCGGAAAGTC TTTCGCACCACCCGCGATCGGCACGGCCGCGCCCCCGCTTTTATAAAGGCTCAGATGACG CAGCAAAAACAGGCCACA GCACCACGTGGGTAGGTGATGTAATTTTATTTTCCTCGTCTGCGGCCTAATGGATTTCCG GGCGCGGTGCCCCTGTCT GCAGAGCACTTAACGGATTGATATCTCGCGGGCACGCGCGCCCTTAATGGACCGGCGCGG GGCGGGGGGCCGGATACC CACACGGGCGGGGGGGGGGTGTCGCGGGCCGTCTGCTGGCCCGCGGCCACATAAACAATG ACTCTGGGCCTTTCTGCC TCTGCCGCTTGTGTGTGCGCGCGCCGGCTCTGCGGTGTCGGCGGCGGCTGCGGCGGCTGC GGCGGCCGCCGTGTTCGG TCTCGGTAGCCGGCCGGCGGGTGGACTCGCGGGGGGCCGGAGGGTGGAAGGCAGGGGGGT GTAGGATGGGTATCAGGA CTTCCACTTCCCGTCCTTCCATCCCCCGTTCCCCTCGGTTGTTCCTCGCCCCCCCCAACA CCCCGCCGCTTTCCGTTG GGGTTGTTATTGTTGTCGGGATCGTGCGGGCCGGGGGTCGCCGGGGCAGGGGCGGGGGCG TGGGCGGGGGTGCTCGTC GATCGACCGGGCTCAGTGGGGGCGTGGGGTGGGTGGGAGAAGGCGAGGAGACTGGGGTGG GGGTGTCGGTGGGTGGTT GTTTTTTGTGGTTGTTTTTGTGGCTGTTCCCGTCCCCCGTCACCCCCCTCCCTCCGTCCC CTCCGTCCCCCCGTCGCG GGTGTTTGTGTTTGTTTATTCCGACATCGGTTTATTTAAATAAACACAGCCGTTCTGCGT GTCTGTTCTTGCGTGTGG CTGGGGGCTTATATGTGGGGTCCCGGGGGCGGGATGGGGTTTAGCGGCGGGGGGCGGCGC GCCGGACGGGGCGCTGGA GATAACGGCCCCCGGGGAACGGGGGACCGGGGCTGGGTCTCCCGAGGTGGGTGGGTGGGC GGCGGTGGCCGGGCCGGG CCGGGCCGGGCCGGGCCGGGTGGGCGGGGTTTGGAAAAACGAGGAGGAGGAGGAGAAGGA GGGGGGGGGGGAGACGGG GGGAAAGCAAGGACACGGCCCGGGGGGTGGGAGCGCGGGCCGGGCCGCTCGTAAGAGCCG CGACCCGGCCACCGGGGA GCGTTGTCGCCGTCGGTCTGCCGGCCCCCGTCCCTCCCTTTTTTGACCAACCAGCGCCCC CCCCCCCCCTCACCACCA TTCCTACTACCACCACCACCACCACCACCGACACCTCCCGCGCACCCCCGCCCACATCCC CCCCCAACCCGCACCACG AGCACGGGTTGGGGGTAGCAGGGGATCAAAGGGGGGCAAGGCCGGCGGGGCGGTTCGGGG GGGGGGGGGGGGGGCGGG AGACCGAGTAGGCCCCGCCCATCCGCGGCCCCTCCCGGCAGCCACGCCCCCCAGCGTCGG GTGTCACGGGGAAAGAGC AGAGGGGAGAGGGGAGAGGGGGGGAGAGGGGAGAGGGGGGGAGAGGGGAGAGGGGGGGAG AGGGGAGAGGGGGGGAGA GGGGAGAGGGGGGGAGAGGGGAGAGGGGGGGAGAGGGGAGAGGGGGGGAGAGGGGAGAGG GGGGGAGAGGGGAGAGGG GGGGAGGGGGAGAGAGGGGAGAGGGGGTATATAAACCAACGAAAAGCGCGGGAACGGGGA TACGGGGCTTGTGTGGCA CGACGTCGTGGTTGTGTTACTGGGCAAACACTTGGGGACTGTAGGTTTCTGTGGGTGCCG ACCCTAGGCGCTATGGGG ATTTTGGGTTGGGTCGGGCTTATTGCCGTTGGGGTTTTGTGTGTGCGGGGGGGCTTGTCT TCAACCGAATATGTTATT CGGAGTCGGGTGGCTCGAGAGGTGGGGGATATATTAAAGGTGCCTTGTGTGCCGCTCCCG TCTGACGATCTTGATTGG CGTTACGAGACCCCCTCGGCTATAAACTATGCTTTGATAGACGGTATATTTTTGCGTTAT CACTGTCCCGGATTGGAC ACGGTCTTGTGGGATAGGCATGCCCAGAAGGCATATTGGGTTAACCCCTTTTTATTTGTG GCGGGTTTTTTGGAGGAC TTGAGTCACCCCGCGTTTCCTGCCAACACCCAGGAAACAGAAACGCGCTTGGCCCTTTAT AAAGAGATACGCCAGGCG CTGGACAGTCGCAAGCAGGCCGCCAGCCACACACCTGTGAAGGCTGGGTGTGTGAACTTT GACTATTCGCGCACCCGC CGCTGTGTAGGGCGACAGGATTTGGGACCTACCAACGGAACGTCTGGACGGACCCCGGTT CTGCCGCCGGACGATGAA GCGGGCCTGCAGCCGAAGCCCCTCACCACGCCGCCGCCCATCATCGCCACGTTGGACCCC ACCCCGCGACGGGACGCC GCCGCAAAAAGCAGACGCCGACGACCCCACTCCCGGCGCATCTAATGATGCCGCGACGGA AACCCGTCCGGGTTCGGG GGGCGAACCGGCCGCCTGTCGCTCGTCAGGGCCGGCGGGCGCTCCTCGCCGCCCTAGAGG CTGTCCCGCTGGTGTGAC GTTTTCCTCGTCCGCGCCCCCCGACCCTCCCATGGATTTAACAAACGGGGGGGTGTCGCC TGTGGCGACCTCGGCGCC TCTGGACTGGACCACGTTTCGGCGTGTGTTTCTGATCGACGACGCGTGGCGGCCCCTGTT GGAGCCTGAGCTGGCGAA CCCCTTAACCGCCCACCTCCTGACCGAATATAATCGTCGGTGCCAGACCGAAGAGGTGCT GCCGCCGCGGGAGGATGT GTTTTCATGGACTCGTTATTGCACCCCCGACGAGGTGCGCGTGGTTATCATCGGCCAGGA CCCATATCACCACCCCGG CCAGGCGCACGGACTTGCGTTTAGCGTGCGCGCGAACGTGCCGCCTCCCCTGAGTCTTCG GAATGTCTTGGCGGCCGT CAAGAACTGTTATCCCGAGGCACGGATGAGCGGCCACGGTTGCCTGGAAAAGTGGGCGCG GGACGGCGTCCTGTTACT AAACACGACCCTGACCGTCAAGCGCGGGGCGGCGGCGTCCCACTCTAGAATCGGTTGGGA CCGCTTCGTGGGCGGAGT TATCCGCCGGTTGGCCGCGCGCCGCCCCGGCCTGGTGTTTATGCTCTGGGGCGCACATGC CCAGAATGCCATCAGGCC GGACCCTCGGGTCCATTGCGTCCTCAAGTTTTCGCACCCGTCGCCCCTCTCCAAGGTTCC GTTCGGAACATGCCAGCA TTTCCTCGTGGCGAATCGATATCTCGAGACCCGGTCGATTTCACCCATCGACTGGTCGGT TTGAAAGGCATCGACGTC CGGGGTTTTCGTCTGTGGGGGCTTTTGGGTATTTCCGATGAATAAAGACGGTTAATGGTT AAACCTCTGGTCTCATAC GGGTCGGTGATGTCGGGCGTCGGGGGAGAGGGAGTTCCCTCTGTGCTTGCGATTCTAGCC TCGTGGGGCTGGACGTTC GACACGCCAAACCACGAGTCAGGGATATCGCCAGATACGACTCCCGCAGATTCCATTCGG GGGGCCGCTGTGGCCTCA CCTGACCAACCTTTACACGGGGGCCCGGAACGGGAGGCCACAGCGCCGTCTTTCTCCCCA ACGCGCGCGGATGACGGC CCGCCCTGTACCGACGGGCCCTACGTGACGTTTGATACCCTGTTTATGGTGTCGTCGATC GACGAATTAGGGCGTCGC CAGCTCACGGACACCATCCGCAAGGACCTGCGGTTGTCGCTGGCCAAGTTTAGCATTGCG TGCACCAAGACCTCCTCG TTTTCGGGAAACGCCCCGCGCCACCACAGACGCGGGGCGTTCCAGCGCGGCACGCGGGCG CCGCGCAGCAACAAAAGC CTTCAGATGTTTGTGTTGTGCAAACGCACCCACGCCGCTCGAGTGCGAGAGCAGCTTCGG GTCGTTATTCAGTCCCGC AAGCCGCGCAAGTATTACACGTGATCTTCGGACGGGCGGCTCTGCCCCGCCGTCCCCGTG TTCGTCCACGAGTTCGTC TCGTCCGAGCCAATGCGCCTCCACCGAGATAACGTCATGCTGGCCTCGGGGGCCGAGTAA CCGCCCCCCCGCGCCACC CTCACTGCCCGTCGCGCGTGTTTGATGTTAATAAATAACGCATAAATTTGGCTGGTTGTT TGTTGTCTTTAATGGACC GCCCGCAAGGGGGGGGKGGCATTTCAGTGTCGGGTGACGAGCGCGATCCGGCCGGGATCC TAGGACCCCAAAAGTTTG TCTGCGTATTCCAGGGCGGGGCTCAGTTGAATCTCCCGCAGCACCTCTACCAGCAGGTCC GCGGTGGGCTGGAGAAAC TCGGCCGTCCCGGGGCAGGCGGTCGTCGGGGGTGGAGGCGCGGCGCCCACCCCGTGTGCC GCGCCTGGCGTCTCCTCT GGGGGCGACCCGTAAATGGTTGCAGTGATGTAAATGGTGTCCGCGGTCCAGACCACGGTC AAAATGCCGGCCGTGGCG CTCCGGGCGCTTTCGCCGCGCGAGGAGCTGACCCAGGAGTCGAACGGATACGCGTACATA TGGGCGTCCCACCCGCGT TCGAGCTTCTGGTTGCTGTCCCGGCCTATAAAGCGGTAGGCACAAAATTCGGCGCGACAG TCGATAATCACCAACAGC CCAATGGGGGTGTGTTGGATAACAACGCCTCCGCGCGGCAGGCGGTCCTGGCGCTCCCGG CCCCGTACCATGATCGCG CGGGTGCCGTACTCAAAAACATGCACCACCTGCGCGGCGTCGGGCAGTGCGCTGGTCAGC GAGGCCCTGGCGTGGCAT AGGCTATACGCGATGGTCGTCTGTGGATTGGACATCTCGCGGTGGGTAGTGAGTCCCCCG GGCCGGGTTCGGTGGAAC TGTAAGGGGACGGCGGGTTAATATACAATGACCACGTTCGGATCGCGCAGAGCCGATAGT ATGTGCTTACTAATGACG TCATCGCGCTCGTGGCGCTCCCGGAGCGGATTTAAGTTCATGCGAAGGAATTCGGAGGAG GTGGTGCGGGACATGGCC ACGTACGCGCTGTTGAGGCGCAGGTTGCCGGGCGTAAAGCAGATGGCGACCTTGTCCAGG CTAAGGCCCTGGGAGCGC GTGATGGTCATGGCAAGCTTGGAGCTGATGCCGTAGTCGGCGTTTATGGCCATGGCCAGC TCCGTAGAGTCAATGGAC TCGACAAACTCGCTGATGTTGGTGTTGACGACGGACATGAAGCCGTGTTGGTCCCGCAAG ACCACGTAAGGCAGGGGG GCCTCTTCCAGTAACTCGGCCACGTTGGCCGTCGCGTGCCGCCTCCGCAGCTCGTCCGCA AAGGCAAACACCCGTGCG TACGTGTATCCCATGAGCGTATAATTGTCCGTCTGCAGGGCGACGGACATCAGCCCCCCG CGCGGCGAGCCGGTCAGC ATCTCGCAGCCCCGGAAGATAACGTTGTCCACGTACGTGCTAAAGGGGGCGCCTTCAAAT GCCTCCCCAAAGAGCTCT TGGAGGATTCGGAATCTCCCGAGGAAGGCCCGCTTCAGCAGCGCAAACTGGGTGTGAACG GCGGCGGTGGTCTCCGGT TCCCCGGGGGTGTAGTGGCAGTAAAACACGTCGAGCTGTTGTTCGTCCAGCCCCGCGAAA ATAACGTCGAGGTCGTCG TCGGGAAAATCGTCCGGGCCCCCGTCCCGCGGCCCCAGTTGCTTAAAATCAAACGCACGC TCGCCGGGGGCGCCTGCG TCGGCCATTACCGACGCCTGCGTCGGCACCCCCGAAGATTTGGGGCGCAGAGACAGAATC TCCGCCGTTAGTTCTCCC ATGCGGGCGTAGGCGAGGGTCCTCTGGGTCGCATCCAGGCCCGGGCGCTGCAGAAAGTTG TAAAAGGAGATAAGCCCG CTAAATATGAGCCGCGACAGGAACCTGTAGGCAAACTCCACCGAAGTCTCCCCCTGAGTC TTTACAAAGCTGTCGTCA CGCAACACTGCCTCGAAGGCCCGGAACGTCCCACTAAACCCAAAAACCAGTTTTCGCAGG CGCGCGGTTACCGCGATC TGGCTGTTGAGGACGTAAGTGACGTCGTTGCGGGCCACGACCAGCTGCTGTTTGCTGTGC ACCTCGCAGCGCATGTGC CCCGCGTCCTGGTCCTGGCTCTGCGAGTAGTTGGTGATGCGGCTGGCGTTGGCCGTGAGC CACTTTTCAATAGTCAGG CCGGGCTGGTGTGTCAGCCGTCGGTATTCGTCAAACTCCTTGACCGACACGAACGTAAGC ACGGGGAGGGTGAACACG ACAAACTCCCCCTCACGGGTCACCTTCAGGTAGGCGTGGAGCTTGGCCATGTACGCGCTC ACCTCTTTGTGGGAGGAG AACAACCGCGTCCAGCCGGGGAGGTTGGCGGGGTTGGTGATGTAGTTTTCCGGGACGACG AAGCGATCCACGAACTGC ATGTGCTCCTCGGTGATGGGTAGGCCGTACTCCAGCACCTTCATGAGGTTACCGAACTCG TGCTCGATGCACCGTTTG TTGTTAATAAAAATGGCCCAGCTATACGAGAGGCGGGCGTACTCCCGCAGCGTGCGGTTG CAGATGAGGTACGTGAGC ACGTTCTCGCTCTGGCGGACGGAACACCGCAGTTTCTGGTGCTCGAAGGTCGACTCCAGG GACGCCGTCTGTGTCGGC GAGCCCACACACACCAACACGGGCCGCAGGCGGGCCGCGTACTGGGGGGTGTGGTACAGG GCGTTAATCATCCACCAG CAATACACCACGGCCGTGAGGAGGTGACGCCCAAGGAGCCCGGCCTCGTCGATGACGATC ACGTTGCTGCGGGTAAAG GCCGGCAGCGCCCCGTGGGTGGCCGGGGCCAACCGCGTCAGGGCGCCCTCGGCCAACCCC AGGGTCCGTTCCAGGGCG GCCAGGGCGCGAAACTCGTTCCGCGACTCCTCGCCCCCGGAGGCGGCCAGGGTGCGCTTC GTGAGGTCCAAAATCACC TCCCAGTAGTACGTCAGATCTCGTCGCTGCAGGTCCTCCAGCGAGGCGGGGTTGCTGGTC AGGGTGTACGGGTACTGC CCCAGTTGGGCCTGGACGTGATTCCCGCGAAACCCAAATTCATGAAAGATGGTGTTGATG GGTCGGCTGAGAAAGGCG CCCGAGAGTTTGGCGTACATGTTTTGGGCCGCAATGCGCGTGGCGCCCGTCACCACACAG TCCAAGACCTCGTTGATT GTCTGCACGCACGTGCTCTTTCCGGAGCCAGCGTTGCCGGTGATAAGATACACCGCGAAC GGAAACTCCCTGAGGGGC AGGCCTGCGGGGGACTCTAAGGCCGCCACGTCCCGGAACCACTGCAGACGGGGCACTTGC GCTCCGTCGAGCTGTTGT TGCGAGAGCTCTCGGATGCGCTTAAGGATTGGCTGCACCCCGTGCATAGACGTAAAATTT AAAAAGGCCTCGGCCCTC CCTGGAACGGCTGGTCGGTCCCCGGGTTGCTGAAGGTGCGGCGGGCCGGGTCTCTGTCCG TCTAGCTGGCGCTCCCCG CCGGCCGCCGCCATGACCGCACCACGCTCGCGGGCCCCCACTACGCATGCGCGGGGGGAC ACGGAAGCGCTGTGCTCC CCCGAGGACGGCTGGGTAAAGGTTCACCCCACCCCCGGTACGATGCTGTTCCGCGAGATT CTCCACGGGCAGCTGGGG TATACCGAGGGCCAGGGGGTGTACAACGTCGTCCGGTCCAGCGAGGCGACCACCCGGCAG CTGCAGGCGGCGATCTTT CACGCGCTCCTCAACGCCACCACTTACCGGGACCTCGAGGCGGACTGGCTCGGCCACGTG GCGGCCCGCGGTCTGCAG CCCCAACGGCTGGTTCGCCGGTACAGGAACGCCCGGGAGGCGGATATCGCCGGGGTGGCC GAGCGGGTGTTCGACACG TGGCGGAACACGCTTAGGACGACGCTGCTGGACTTTGCCCACGGGTTGGTCGCCTGCTTT GCGCCGGGCGGCCCGAGC GGCCCGTCAAGCTTCCCCAAATATATCGACTGGCTGACGTGCCTGGGGCTGGTCCCCATA TTACGCAAGCGACAAGAA GGGGGTGTGACGCAGGGTCTGAGGGCGTTTCTCAAGCAGCACCCGCTGACCCGCCAGCTG GCCACGGTCGCGGAGGCC GCGGAGCGCGCCGGCCCCGGGTTTTTTGAGCTGGCGCTGGCCTTCGACTCCACGCGCGTG GCGGACTACGACCGCGTG TATATTTACTACAACCACCGCCGGGGCGACTGGCTCGTGCGAGACCCCATCAGCGGGCAG CGCGGAGAATGTCTGGTG CTGTGGCCTCCCTTGTGGACCGGGGACCGTCTGGTCTTCGATTCGCCCGTACAGCGGCTG TTTCCCGAGATCGTCGCG TGTCACTCCCTCCGGGAACACGCGCACGTCTGCCGGCTGCGCAATACCGCGTCCGTCAAG GTGCTGCTGGGGCGCAAG AGCGACAGCGAGCGCGGGGTGGCCGGCGCCGCGCGGGTCGTTAACAAGGTGTTGGGGGAG GACGACGAGACCAAGGCC GGGTCGGCCGCCTCGCGCCTCGTGCGGCTTATCATCAACATGAAGGGCATGCGCCACGTA GGCGACATTAACGACACT GTGCGTGCCTACCTCGACGAGGCCGGGGGGCACCTGATAGACGCCCCGGCCGTCGACGGT ACCCTCCCGGGATTCGGC AAGGGCGGAAACAGCCGCGGGTCTGCGGGCCAGGACCAGGGGGGGCGGGCGCCGCAGCTT CGCCAGGCCTTCCGCACG GCCGTGGTTAACAACATCAACGGCGTGTTGGAGGGCTATATAAATAACCTGTTTGGAACC ATCGAGCGCCTGCGCGAG ACCAACGCGGGCCTGGCGACCCAGTTGCAGGAGCGCGACCGCGAGCTCCGGCGCGCAACA TCGGGGGCCCTGGAGCGC CAGCAGCGCGCGGCCGACCTGGCGGCCGAGTCCGTGACCGGGGGATGCGGCAGCCGCCCT GCGGGGGCGGACCTGCTC C GG G C C GAC TAT GAC AT TAT C GAC GT C AG C AAGT C CAT G GAC GAC GAC AC GTACGTCGC C AAC AGT T T T C AGT AC C C G TACATCCCTTCGTACGCCCAGGACCTGGAGCGCCTGTCGCGCCTCTGGGAGCACGAGCTG GTGCGCTGTTTCAAAATT CTGTGTCACCGCAACAACCAGGGCCAAGAGACGTCGATCTCGTACTCCAGCGGGGCGATC GCCGCATTCGTCGCCCCC TACTTTGAGTCAGTGCTTCGGGCCCCCCGGGTAGGCGCGCCATCACGGGCTCCGATGTCA TCCTGGGGGAGGAGGAGT TATGGGATGCGGTGTTTAAGAAAACCCGCCTGCAAACGTACCTGACAGACATCGCGGCCC TGTTCGTCGCGGACGTCC AGCACGCAGCGCTGCCCCCGCCCCCCTCCCCGGTCGGCGCCGATTTCCGGCCCGGCGCGT CCCCGCGGGGCCGGTCCA GATCGCGGTCGCCCGGAAGAACTGCGCGAGGCGCGCCGGACCAGGGCGGGGGCATCGGGC ACCGGGATGGCCGCCGCG ACGGCCGACGATGAGGGGTCGGCCGCCACCATCCTCAAACAGGCCATCGCCGGGGACCGC AGCCTGGTCGAGGCGGCC GAGGCGATTAGCCAGCAGACGCTGCTCCGCCTGGCCTGCGAGGTGCGCCAGGTCGGCGAC CGCCAGCCGCGGTTTACC GCCACCAGCATCGCGCGCGTCGACGTCGCGCCTGGGTGCCGGTTGCGGTTCGTTCTGGAC GGGAGTCCCGAGGACGCC TATGTGACGTCGGAGGATTACTTTAAGCGCTGCTGCGGCCAGTCCAGTTATCGCGGCTTC GCGGTGGCGGTCCTGACG GCCAACGAGGACCACGTGCACAGCCTGGCCGTGCCCCCCCTCGTTCTGCTGCACCGGTTC TCCCTGTTCAACCCCAGG GACCTCCTGGACTTTGAGCTTGCCTGTCTGCTGATGTACCTGGAGAACTGCCCCCGAAGC CACGCCACCCCGTCGACC TTTGCCAAGGTTCTGGCGTGGCTCGGGGTCGCGGGTCGCCGCACGTCCCCATTCGAACGC GTTCGCTGCCTTTTCCTC CGCAGTTGCCACTGGGTCCTAAACACACTCATGTTCATGGTGCACGTAAAACCGTTCGAC GACGAGTTCGTCCTGCCC CACTGGTACATGGCCCGGTACCTGCTGGCCAACAACCCGCCCCCCGTTCTCTCGGCCCTG TTCTGTGCCACCCCGACA AGCTCCTCATTCCGGCTGCCGGGGCCGCCCCCCCGCTCCGACTGCGTGGCCTATAACCCC GCCGGGATCATGGGGAGC TGCTGGGCGTCGGAGGAGGTGCGCGCGCCTCTGGTCTATTGGTGGCTTTCGGAGACCCCA AAACGACAGACGTCGTCG CTGTTTTATCAGTTTTGTTGAATTTTAGGAAATAAACCCGGTTTTGTTTCTGTGGCCTCC CGACGGATGCGCGTGTCC TTACTCCGTCTTGGTGGGTGGGTGGCTGTGTATGGCGTCCCATCTGTGCGGGGAGGGGGG CAAGTCGGCACGTATTCG GACAGACTCAAGCACACACGGGGGAGCGCTCTTGTCTCAGGGCAATGTTTTTATTGGTCA AACTCAGGCAAACAGAAA CGACATCTTGTCGTCAAAGGGATACACAAACTTCCCCCCCTCGCCCCATACTCCCGCCAG CACCCCGGTAAACACCAA CTCAATCTCGCGCAGGATTTCGCGCAGGTGATGAGCGCAGTCCACGGGGGGGAGCACAAG GGGCCGCGGGTATAGATC GACGGGGACGCCGACCGACTCCCCGCCTCCGGGACAGACACGCACGACGCGCCGCCAGTA GTGCTCTGCGTCCAGCAA GGCGCCGCCGCGGAAGGCAGTGGGGGGCAAGGGGTCGCTGGCCTCAAAGGGGGACACCCG AACGCTCCAGTACTCCGC GTCCAACCGTTTATTAAACGCGTCCAAGATAAGGCGGTCGCAGGCGTCCTCCATAAGGCC CCGGGCCGTGAGTGCGTC CTCCTCCGGCACGCCTGCCGTTGTCAGGCCCAGGACCCGTCGCAGCGTGTCGCGTACGAC CCCGGCCGCCGTGGTGTA CGCGGGCCCGCGGAGAGGAAATCCCCCAAGATGGTCAGTGTTGTCGCGGGAGTTCCAGAA CCACACTCCCGCCTGGCT CCAGGCGACTGCGTGGGTGTAGACGCCCTCGAGGGCCAGGCACAGTGGGTGCCGCAGCCG GAGGCCGTTGGCCCTAAG CACGGCTCCCACGGCCGTCTCGATGGCCCGCCGGGCGTCCTCGATCACCCCGGAAGCCGC ATCCGCGTCTTGGGGGTC CACGTTAAAGACACCCCAGAACGCACCCCCATCGCCCCCGCAGACCGCGAACTTCACCGA GCTGGCCGTCTCCTCGAT CTGCAGGCAGACGGCGGCCATTACCCCACCCAGGAGCTGCCGCAGCGCAGGGCAGGTGTT GCACGTGTCCGGGACCAG GCGCTCCAAGACGGCCCCGGCCCAGGGCTCTGAGGGAGCGGCCACCACCAGCGCGTCCAG TCTTGCTAGGCCCGTCCG GCCGTGGGGGTCCGCCAGCCCGCTCCCCCCGAGGTCGGCCAGGGCCGCCAGGAGCTGGGC GCGAAGTCCGGGGAAGCA AAACCGCGCCGTCCAGACGGGCCCGACGGCCGCGGGCGGGTCTAACAGTTGGATGATTTT AGTGGCGGGATGCCACCG CGCCACCGCCTCCCGCACTGCGGGCAGGAGGCATCCGGCTGCCGCCGAGGCCACGCCGGG CCAGGCTCGCGGGGGGAG GACGACCCTGACCCCCACCGCGGGCCAGGCCCCCAGGAGCGCGGCGTAAGCGGCCGCGGC CCCGCGCACCAGGTCCCG TGCCGACTCGGCCGTGGCCGGCACGGTGAACGTGGGCCAACCCGGAAACCCCAGGACGGC AAAGTACGGGACGGGTCC CCCCCGGACCTCAAACTCGGGCCCCAGAAAGGCAAAGACGGGGGCCAGGGCCCCGGGGGC GGCGTGGACCGTGGTATG CCACTGCCGGAAAAGGGCGACGAGCGCCGGCGCGGAGAACTTCTCGCCGGCGCTTACAAA GTAGTCGTAATCGCGGGG CAGCAGCACCCGTGCCGTGACTCGTTGTGGGTGCCCGCGTGGCCGCAGGCCCACCTCGCA CACCTCGACCAGGTCCCC GAACGCGCCCTCCTTCTTGATCGGCGGAAACGCAAGAGTCTGGTATTCGCGCGCAAATAG CGCGGTTCCGGTGGTGAT GTTAACGGTCAGCGAAGCGGTGGACGCGCACTGGGGGGTGTCGCGAATGGCCGCCAGGCG CGCCCACGCCAGCCGCGC GTCGGGATGCTCGGCAACGCGCGCCGCCAGGGCCATAGGGTCGATGTCAATGTTGGCCTC CGCGACCAGGAGAGCGGC GCGAGGGGCGGCGGGCGGGCCCCACGACGCTCTCTCAACTTTCACCACCAGTCCCGTGCG TGGGTCCGAGCCGATACG CAGCGGGGCGAACAGGGCCACCGGCCCGGTCTGGTGCTCCAGGGCCGCCAGGACGCACGC GTACAGCGCCCGCCACAG AGTCGGGTTCTCCAGGGGCTCCAGCGGGGAGGCGGCCGGCGTCGTCGCGGCGCGGGCGGC CGCCACGACGGCCTGGAC GGAGACGTCCGCGGAGCCGTAGAAATCCCGCAGCTCCGTCGCGGTGACGGAGACCTCCGC AAAGCGCGCGCGACCCTC CCCTGCGGCGTTGCGACATACAAAATACACCAGGGCGTGGAAGTACTCGCGAGCGCGGGG GGGCAGCCATACCGCGTA AAGGGTAATGGCGCTGACGCTCTCCTCCACCCACACGATATCTGCGGTGTCCATCGCACG GCCCCTAAGGATCACGGG CGGTCTGTGGGTCCCATGCTGCCGTGCCTGGCCGGGCCCGGTGGGTTGCGGAAACCGGTG ACGGGGGGGGGGCGGTTT TTGGGGTTGGGGTGGGAAACGGCCCGGGTCCGGGGGCCAACTTGGCCCCTCGGTGCGTTC CGGCAACAGCGCCGCCGG TCCGCGGACGACCACGTACCGAACGAGTGCGGTCCCGAGACTTATAGGGTGCTAAAGTTC ACCGCCCCCTGCATCATG GGCCAGGCCTCGGTGGGGAGCTCCGACAGCGCCGCCTCCAGGATGATGTCAGCGTTGGGG TTGGCGCTGGATGAGTGC GTGCGCAAACAGCGCCCCCACGCGGGCACGCGTAGCTTGAAGCGCGCGCCCGCAAACTCC CGCTTGTGGGCCATAAGC AGGGCGTACAGCTGCCTGTGGGTCCGGCAGGCGCTGTGGTCGATGTGGTGGGCGTCCAAC AACCCCACGATTGTCTGT TTGGTGAGGTTTTTAACGCGCCCCGCCCCGGGAAACGTCTGCGTGCTTTTGGCCATCTGC ACGCCAAACAGTTCGCCC CAGATTATCTTGAACAGCGCCACCGCGTGGTCCGTCTCACTAACGGACCCGCGCGGGGGA CAGCCGCTTAGGGCGTCG GCGACGCGCTTGACGGCTTCCTCCGAGAGCAGAAGTCCGTCGGTTACGTTACAGTGGCCC AGTTCGAACACCAGCTGC ATGTAGCGGTCGTAGTGGGGGGTCAGCAGGTCCAGCACGTCATCGGGGCCGAAGGTCCTC CCAGATCCCCCGGCCGCC GAGTCCCAATGCAGGCGCGCGGCCATGGTGCTGCACAGGCACAACAGCTCCCAGACAGGG GTTACGTTCAGGGTGGGG GGCAGGGCCACGAGCTCCAGCTCTCCGGTGACGTTGATCGTGGGGATGACGCCCGTGGCG TAGTGGTCATAGATCCGC CGAAATATGGCGCTGCTGCGGGTGGCCATGGGAACGCGGAGACAGGCCTCCAGCAACGCC AGGTAAATAAACCGCGTG CGTCCCATCAGGCTGTTGAGGTTGCGCATGAGCGCGACAATTTCCGCCGGCGCGACATCG GACCGGAGGTATTTTTCG ACGAAAAGACCCACCTCCTCCGTCTCGGCGGCCTGGGCCGGCAGCGACGCCTCGGGATCC CGGCACCGCAGCTCCCGT AGATCGCGCTGGGCCCTGAGGGCGTCGAAATGTACGCCCCGCAAAAACAGACAGAAGTCC TTTGGGGTCAGGGTATCG TCGTGTCCCCAGAAGCGCACGCGTATGCAGTTTAGGGTCAGCAGCATGTGAAGGATGTTA AGGCTGTCCGAGAGACAC GCCAGCGTGCATCTCTCAAAGTAGTGTTTGTAACGGAATTTGTTGTAGATGCGCGACCCC CGCCCCAGCGACGTGTCG CATGCCGACGCGTCACAGCGCCCCTTGAACCGGCGACACAGCAGGTTTGTGACCTGGGAG AACTGCGCGGGCCACTGG CCGCAGGAACTGACCACGTGGTTCAGGAGCATGGGCGTAAAGACGGGCTCCGAGCGCGCC CCGGAGCCGTCCATGTAA ATCAGTAGCTCCCCCTTGCGGAGGGTGCGCACCCGTCCCAGGGACTGGTACACGGACACC ATGTCCGGTCCGTAGTTC ATGGGTTTCACGTAGGCGAACATGCCATCAAAGTGCAGGGGATCGAAGCTGAGGCCCACG GTTACGACCGTCGTGTAT ATAACCACGCGGTATTGGCCCCACGTGGTCACGTCCCCGAGGGGGGTGAGCGAGTGAAGC AACAGCACGCGGTCCGTA AACTGACGGCAGAACCGGGCCACGATCTCCGCGAAGGAGACCGTCGACGAAAAAATGCAG ATGTTATCGCCCCCGCCA AGGCGCGCTTCCAGCTCCCCAAAGAACGTGGCCCCCCGGGCGTCCGGAGAGGCGTCCGGA GACGGGCCGCTCGGCGGC CCGGGCGGGCGCAGGGCAGCCTGCAGGAGCTCGGTCCCCAGACGCGGGAGAAACAGGCAC CGGCGCGCCGAAAACCCG GGCATGGCGTACTCGCCGACCACCACATGCACGTTTTTTTCGCCCCGGAGACCGCACAGG AAGTCCACCAACTGCGCG TTGGCGGTTGCGTCCATGGCGATGATCCGAGGACATGTGCGCAGCAGGCGTAGCATTAAC GCATCCACGCGGCCCAGT TGCTGCATCGTTGGCGAATAGAGCTGGCCCAGCGTCGACATAACCTCGTCCAGAACGAGG ACGTCGTAGTTGTTCAGA AGGTTGGGGCCCACGCGATGAAGGCTTTCCACCTGGACGATAAGTCGGTGGAAGGGGCGG TCGTTCATAATGTAATTG GTGGATGAGAAGTAGGTGACAAAGTCGACCAGGCCTGACTCAGCGAACCGCGTCGCCAGG GTCTGGGTAAAACTCCGA CGACAGGAGACGACGAGCACACTCGTGTCCGGAGAGTGGATCGCTTCCCGCAGCCAGCGG ATCAGCGCGGTAGTTTTT CCCGACCCCATTGGCGCGCGGACCACAGTCACGCACCTGGCCGTCGGGGCGCTCGCGTTG GGGAAGGTGACGGGTCCG TGCTGCTGCCGCTCGATCGTTGTTTTCGGGTGAACCCGGGGCACCCATTCGGCCAAATCC CCCCCGTATAACATCCGC GCTAGCGATACGCTCGACGTGTACTGTTCGCACTCGTCGTCCCCAATGGGACGCCCGGCC CCCAGAGGATCCCCCGAC TCCGCGCCCCCCACGAAAGGCATGACCGGGGCGCGGACGGCGTGGTGGGTCTGGTGTGTG CAGGTGGCGACGTTTGTG GTCTCTGCGGTCTGCGTCACGGGGCTCCTCGTCCTGGCCTCTGTGTTCCGGGCACGGTTT CCCTGCTTTTACGCCACG GCGAGCTCTTATGCCGGGGTTAACTCCACGGCCGAGGTGCGCGGGGGTGTAGCCGTGCCC CTCAGGTTGGACACGCAG AGCCTTGTGGGCACTTATGTAATCACGGCCGTATTGTTGTTGGCCGCGGCCGTGTATGCC GTGGTCGGCGCCGTGACC TCCCGCTACGACCGCGCCCTGGACGCGGGCCGCCGTCTGGCTGCGGCCCGCATGGCCATG CCGCACGCCACGCTGATC GCCGGAAACGTCTGCTCTTGGTTGCTGCAGATCACCGTCCTGCTGCTGGCCCATCGCATC AGCCAGCTGGCCCACCTG GTTTACGTCCTGCACTTTGCGTGTCTGGTGTATTTTGCGGCCCATTTTTGCACCAGGGGG GTCCTGAGCGGGACGTAT CTGCGTCAGGTGCACGGCCTGATGGAGCTGGCCCCGACCCATCATCGCGTCGTCGGCCCG GCTCGCGCCGTGCTGACA AACGCCTTGCTGTTGGGCGTCTTCCTGTGCACGGCCGACGCCGCGGTATCCCTGAATACC ATCGCCGCGTTCAACTTT AATTTTTCGGCCCCGGGCATGCTCATCTGCCTGACCGTGCTGTTCGCCATTCTCGTCGTA TCGCTGTTGTTGGTGGTC GAGGGGGTGTTGTGTCACTACGTGCGCGTGTTGGTGGGCCCCCACCTGGGGGCCGTTGCC GCCACGGGCATCGTCGGC CTGGCCTGCGAGCACTATTACACCAACGGCTACTACGTGGTGGAGACGCAGTGGCCGGGG GCACAGACGGGAGTGCGC GTCGCCCTCGCCCTGGTCGCCGCCTTTGCCCTCGGCATGGCCGTGCTCCGCTGCACCCGC GCCTATCTGTATCACAGG CGGCACCACACCAAATTTTTTATGCGCATGCGCGACACGCGACACCGCGCACATTCCGCC CTCAAGCGCGTACGCAGT TCCATGCGCGGATCGCGAGACGGCCGCCACAGGCCCGCGCCCGGCAGCCCGCCCGGGATT CCCGAATATGCGGAAGAC CCCTACGCGATCTCATACGGCGGCCAGCTCGACCGGTACGGAGATTCCGACGGGGAGCCG ATTTACGACGAGGTGGCG GAC GAC C AAAC C GAC GT AT T GT AC G C C AAGAT AC AAC AC C C G C G GC AC C T GC C C GAC GAC GAG C C CAT CT AT GAC AC C GTTGGGGGGTACGACCCCGAGCCCGCCGAGGACCCCGTGTACAGCACCGTCCGCCGTTGG TAGCTGTTTGGTTCCGTT TTAATAAACCGTTTGTGTTTAACCCGACCGTGGTGTATGTCTGGTGTGTGGCGTCCGATC CCGTTACTATCACCGTCC CCCCCCCCCCTCAACCCCGGCGATTGTGGGTTTTTTAAAAACGACACGCGTGCGACCGTA TACAGAACATTATTTTGG TTTTTATTCGCTATCGGACATGGGGGGTGGAAACTGGGTGGCGGGGCAGGCGCCTCCGGG GGTCCGCCGGTGAGTGTG GCGCGAGGGGGGGTCCGACGAACGCAGGCGCGGTCTCCCCGGGGCCCGCGTAACCACGCG CATATCCGGGGGCACGTA GAAATTACCTTCCTCTTCGGACTCGATATCCACGACGTCAAAGTCGTGGGCGGTCAGCGA GACGACCTCCCCGTCGTC GGTGATGAGGACGTTGTTTCGGCAGCAGCAGGGCCGGGCCCCGGAGAACGAGAGGCCCAT AGCTCGGCGAGCGTGTCG TCGAACGCCAGGCGGCTGCTTCGCTGGATGGCCTTATAGATCTCCGGATCGATGCGGACG GGGGTAATGATCAGGGCG ATCGGAACGGCCTGGTTCGGGAGAATGGACGCCTTGCTGGGTCCTGCGGCCCCGAGAGCC CCGGCGCCGTCCTCCAGG CGGAACGTTACGCCCTCCTCCGCGCTGGTGCGGTGCCTGCCGATAAACGTCACCAGATGC GGGTGGGGGGGGCAGTCG GGGAAGTGGCTGTCGAGCACGTAGCCCTGCACCAAGATCTGCTTAAAGTTCGGGTGGCGG GGGTTCGCGAAGACGGGC TCGCGGCGGACCAGATCCCCGGAGCTCCAGGACACGGGGGAGATGGTGTGGCGTCCGAGG TCGGGGGCGCCAAACAGA AGCACCTCCGAGACAACGCCGCTATTTAACTCCACCAAGGCCCGATCCGCGGCGGAGCAC CGCCTTTTTTCGCCCGAG GCGTGGGCCTCTGACCAGGCCTGGTCTTGCGTGACGAGAGCCTCCTCCGGGCCGGGGACG CGCCCGGGCGCGAAGTAT CGCACGCTGGGCTTCGGGATCGACCGGATAAATGCCCGGAACGCCTCCGGGGACCGGTGT GCCATCAAGTCCTCGTAC GCGGAGGCCGTGGGGTCGCTGGGGTCCATGGGGTCGAAAGCGTACTTGGCCCGGCATTTG ACCTCGTAAAAGGCCAGG GGGGTCTTGGGGACTGGGGCCAGGTAGCCGTGAATGTCCCGAGGACAGACGAGAATATCC AGGGACGCCCCGACCATC CCCGTGTGACCGTCCATGAGGACCCCACACGTATGCACGTTCTCTTCGGCGAGGTCGCTG GGTTCGTGGAAGATAAAG CGCCGCGTGTCGGCGCCGGCCTCGCCGCCGTCGTCCGCGCGGCCCACGCAGTAGCGAAAC AGCAGGCTTCGGGCCGTC GGCTCGTTCACCCGCCCGAACATCACCGCCGAAGACTGTACATCCGGTCGCAGGCTGGCG TTGTGCTTCAGCCACTGG GGCGAGAAACACGGACCCTGGGGGCCCCAGCGGAGGGTGGATGCGGTCGTGAGGCCCCGC CGGAGCAGGGCCCATAGC TGGCAGTCGGCCTGGTTTTGCGTGGCCGCCTCGTAAAACCCCATGAGGGGCCGGGGCGCC ACGGCGTCCGCGGCGGCC GGGGGGGCGCGGCGCGTCAGGCGCCATAGGTGCCGGCCGAGTCCGCGGTCCACCATACCC GCCTCCTCGAGGACCACG GCCAGGGAACACAGATAATCCAGGCGGGCCCAGAGGGGACCGATGGCCAGAGGGGCGCGG ACGCCGCGCAGCAACCCG CGCAGGTGGCGCTCGAACGTCTCGGCTAGTATATGGGAGGGCAGCGCGTTGGGGATCACC GACGCCGACCACATAGAG TCAAGGTCCGGGGAGTCGGGATCGGCGTCCGGGTCGCGGGCGTGGGTGCCCCCAGGAGAT AGCGGAATGTCCGGGGTC GGAGGCCCGGAGGCGTCAGAAAGTGCCGGCGACGCGGCCCGGGGCTTTTCGTCTGCGGTG TCGGTGGCGTGCTGATCA CGTGGGGGGTTATCGGGCGAATGGGAGCTCGGGTCCACAGCTGACGTCGTCTGGGGTGGG GGGGGCAGGGGACGGAAG GTGGTTGTCAGCGGAAGACTGTTAGGGCGGGGGCGCTTGGGGGGGCTGTCGGGGCCACGA GGGGTGTCCTCGGCCAGG GCCCAGGGACGCTTAGTCACGGTGCGTCCCGGCGGACATGCTGGGCCTACCGTGGACTCC ATTTCCGAGACGACGTGG GGGGAGCGGTGGTTGAGCGCGCCGCCGGGTGAACGCTGATTCTCACGACAGCGCGTGCCG CGCGCACGGGTTGGTGTG ATACAGGCGGGACACCAGCACCAGGAGAGGCTTAAGCTCGGGAGGCAGCGCCACCGACGA CAGTATCGCCTTGTGTGT GTGCTGGTAATTTATACACCGATCCGTAAACGCGCGCCGAATCTTGGGATTGCGGAGGTG GCGCCGGATGCCCTCTGG GACGTCATACGCCAGGCCGTGGGTGTTGGTCTCGGCCGAGTTGACAAACAGGGCTGGGTG CAGCACGCAGCGATAGGC GAGCAGGGCCAGGGCGAAGTCCGGCGACAGCTGGTTGTTGAAATACTGGTAACCGGGAAA CCGGGTCACGGGTACGCC CAGGCTCGGGGCGACGTACACGCTAACCACCAACTCCAGCAGCGTCTGGCCCAGGGCGTA CAGGTCAACCGCTAGCCC GACGTCGTGCTTCAGGCGGTGGTTGGTAAATTCGGCCCGTTCGTTGTTAAGGTATTTCAC CAACAGCTCCGGGGGCTG GTTATACCCGTGACCCACCAGGGTGTGAAAGTTGGCTGTGGTTAGGGCGGTGGGCATGCC AAACATCCGGGGGGACTT GAGGTCCGGCTCCTGGAGGCAAAACTGCCCCCGGGCGATCGTGGAGTTGGAGTTGAGGGT GACGAGGCTAAAGTCGGC GAGGACGGCCCGCCGGAGCGAGACGGCGTCCGACCGCAGCATGACGAGGATGTTGGCGCA CTTGATATCCAGGTGGCT GATCCCGCAGGTGGTGTTTAAAAACACAACGGCACGGGCCAGCTCCGTGAAGCACTGGTG GAGGGCCGTCGAGACCGA GGGGTTTGTTGTGCGCAGGGACGCCAGTTGGCCGATATACTTACCGAGGTCCATGTCGTA CGCGGGGAACACTATCTG TCGTTGTTGCAGCGAGAACCCGAGGGGCGCGATGAAGCCGCGGATGTTGTGGGTGCGGCC GGCGCGTAGAGCGCACTC CCCGACCAACAGGGTCGCGATGAGCTCAACGGCAAACCACTCCTTTTCCTTTATGGTCTT AACGGCAAGCTTATGTTC GCGAATCAGTTGGACTTCGCCGTATCCCCCAGACCCCCCGAAGCTTCGGGCCCCGGGGAT CTCGAGGGTCGTGTAGTG TAGGGCGGGGTTGATGGCGAACACGGGGCTGCATAGCTTGCGGATGCGCGTGAGGGTGAG GATGTGCGAGGGGGACGA GGGGGGTGCGGTTAACGCCGCCTGGGATCTGCGCAGGGGCGGGCGGTTCAGTTTGGCCGC CGTACCGGGCGCCTCGGG GGACGCGCGGCGATGAGACGAGCGGCTCATTCGCCATCGGGATAGTCCCGCGCGAAGCCG CTCGCGGAGGCCGGATCG GTGGCGGCACCCGTGGGAGGAGCGGGAGACGGCGGCGTTCTGGAGAGAGGGGCCGCTGGG GCGCCCGGAGGCCCCATG GGGGTTGGAGTGTATGTAGGATGCGAGCCAATCCTTGAAGGACCGTTGGCGTGCACCTTG GGGGCTGAGGTTAGCTGC CACATGACCAGCAGGTCGCTGTCTGCGGGACTCATCCATCCTTCGGCCAGGTCGCCGTCT CCCCACAGAGAAGCGTTG GTCGCTGCCTCCTCGAGTTGCTCCTCCTGGTCCGCAAGACGATCGTCCACGGCGTCCAGG CGCTCACCAAGCGCCGGA TCGAGGTACCGTCGGTGTGCGGTTAGAAAGTCACGACGCGCCGCTTGCTCCTCCACGCGA ATTTTAACACAGGTCGCG CGCTGTCGCATCATCTCTAAGCGCGCGCGGGACTTTAGCCGCGCCTCCAATTCCAAGTGG GCCGCCTTTGCAGCCATA AAGGCGCCAACAAACCGAGGATCTTGGGTGCTGACGCCCTCCCGGTGCAGCTGCAGGGTC TGGTCCTTGTAAATCTCG GCTCGGAGGTGCGTCTCGGCCAGGCGTCGGCGCAGGGCCGCGTGGGCGGCATCTCGGTCC ATTCCGCCACCCTGCGGG CGACCCGGGGGTGCTCTGATAGTCTCGCGTGCCCAAGGCCCGTGATCGGGGTACTTCGCC GCCGCGACCCGCCACCCG GTGTGCGCGATGTTTGGTCAGCAGCTGGCGTCCGACGTCCAGCAGTACCTGGAGCGCCTC GAGAAACAGAGGCAACTT AAGGTGGGCGCGGACGAGGCGTCGGCGGGCCTCACAATGGGCGGCGATGCCCTACGAGTG CCCTTTTTAGATTTCGCG ACCGCGACCCCCAAGCGCCACCAGACCGTGGTCCCGGGCGTCGGGACGCTCCACGACTGC TGCGAGCACTCGCCGCTC TTCTCGGCCGTGGCGCGGCGGCTGCTGTTTAATAGCCTGGTGCCGGCGCAACTAAAGGGG CGTGATTTCGGGGGCGAC CACACGGCCAAGCTGGAATTCCTGGCCCCCGAGTTGGTACGGGCGGTGGCGCGACTGCGG TTTAAGGAGTGCGCGCCG GCGGACGTGGTGCCTCAGCGTAACGCCTACTATAGCGTTCTGAACACGTTTCAGGCCCTC CACCGCTCCGAAGCCTTT CGCCAGCTGGTGCACTTTGTGCGGGACTTTGCCCAGCTGCTTAAACCTCCTTCCGGGCCT CCAGCCTCACGGAGACCA CGGGCCCCCCCAAAAAACGGGCCAAGGTGGACGTGGCCACCCACGGCCGGACGTACGGCA CGCTGGAGCTGTTCCAAA AAATGATCCTTATGCACGCCACCTACTTTCTGGCCGCCGTGCTCCTCGGGGACCACGCGG AGCAGGTCAACACGTTCC TGCGTCTCGTGTTTGAGATCCCCCTGTTTAGCGACGCGGCCGTGCGCCACTTCCGCCAGC GCGCCACCGTGTTTCTCG TCCCCCGGCGCCACGGCAAGACCTGGTTTCTGGTGCCCCTCATCGCGCTGTCGCTGGCCT CCTTTCGGGGGATCAAGA TCGGCTACACGGCGCACATCCGCAAGGCGACCGAGCCGGTGTTTGAGGAGATCGACGCCT GCCTGCGGGGCTGGTTCG GTTCGGCCCGAGTGGACCACGTTAAAGGGGAAACCATCTCCTTCTCGTTTCCGGACGGGT CGCGCAGTACCATCGTGT TTGCCTCCAGCCACAACACAAACGTAAGTCCTCTTTTCTTTCGCATGGCTCTCCCAAGGG GCCCCGGGTCGACCCGAC C CAC AC C C AC C CAC C CAC AT ACAC ACAC AAC CAGAC G C G G GAG GAAAGT CTGCCCCGTG G GC AC T GAT T T T TAT T C G G GATCGCTTGAGGAGGCCCGGGCAACGGCCCGGGCAACGGTGGGGCAACTCGTAGCAAATA GGCGACTGATGTACGAAG AGAAGACACACAGGCGCCACCCGGCGCTGGTCGGGGGGATGTTGTCCGCGCCGCACCGTC CCCCGACGACCTCTTGCA GACGGTCCGTGATGCAAGGACGGCGGGGGGCCTGCAGCAGGGTGACCGTATCCACGGGAT GGCCAAAGAGAAGCGGAC ACAGGCTAGCATCCCCCTGGACCGCCAGGGTACACTGGGCCATCTTGGCCCACAGACACG GGGCGACGCAGGGACAGG ACTCCGTTACGACGGAGGAGAGCCACAGTGCGTTGGCGGAATCGATGTGGGGCGGCGGGG CGCAGGACTCGCAGCCCC CCGGGTGGTTAGTGATCCTGGCCAGGAGCCATCCCAGATGGCGGGCCCTGCTTCCCGGTG GACAGAGCGACCCCAGGT CGCTGTCCATGGCCCAGCAGTAGATCTGGCCGCTGGGGAGGTGCCACCAGGCCCCCGGGC CCAAGGCGCAGCACGCGC CCGGCTCCGGGGGGGTCTTCGCGGGGACCAGATACGCGCCATCCAGCTCGCCGACCACTG GCTCCTCCGCGAGCTGTT CGGTGGTTGGGTCGGGGGTTTCCTCCGGGGGGGTGGCCGCCCGTATGCGGGCGAACGTGA GGGTGCACAGGAGCGGGG TCAGGGGGTGCGTCACGCTCCGGAGGTGGACGATCGCGCAGTAGCGGCGCTCGCGGTTAA AGAAAAAGAGGGCAAAGA AGGTGTTCGGGGGCAACCGCAGCGCCTTGGGGCGCGTCAGATACAGAAAAATCTCGCAGA AGAGGGCGCGCCCGGGGT CTGGGTTAGGAAGGGCCACCTGACACAGAGGCTCGGTGAGGACCGTTAGACACCGAAAGA TCTTGAGCCGCTCGTCCG CCCGAACGACGCGCCACACAAAGACGGAGTTGACAATGCGCGCGATAGAGTCGACGTCCG TCCCCAGGTCGTCGACTC TGTCGCGCGTGCCGCGAGCTCCGGCCCGGGAATCCGGCCGGGGCAAGGTCCCCGGGGGAC CAGGCGGCGCCAGGGGCC GCCGGGGTCCCAGCTGCGCCATGCCGGGGGCGGGGGGAGGGCAAACCCCAGAGGCGGGGG CCAACGGCGCGGGGAGGA GTGGATGGGCGAGGTGGCCGGGGGAAGGCGCCCGCTAGCGAGAACGGCCGTTCCCGGACG ACACCTTGCGACAAAACC TAAGGACAGCGGCCCGCGCGACGGGGTCCGAGAGGCTAAGGTAGGCCGCGATGTTAATGG TGAACGCAAAGCCGCCGG GAAAGACAACTATGCCACAGAGGCGGCGATTAAACCCCAGGCAGAGGTAGGCGTAGCTTT CCCCGGGCAGGTATTGCT CGCAGACCCTGCGTGGGGCTGTGGAGGGGACGGCCTCCATGAAGCGACATTTACTCTGCT CGCGTTTACTGACGTCAC CATCCATCGCCACGGCGATTGGACGATTGTTAAGCCGCAGCGTGTCTCCGCTTGTGCTGT AGTAGTCAAAAACGTAAT GGCCGTCGGAGTCGGCAAAGCGGGCCGGGAGGTCGTCGCCGAGCGGGACGACCCGCCGCC CCCGACCGCCCCGTCCCC CCAGGTGTGCCAGGACGGCCAGGGCATACGCGGTGTGAAAAAAGGCGTCGGGGGCGGTCC CCTCGACGGCGCGCATCA GGTTCTCGAGGAGAATGGGGAAGCGCCTGGTCACCTCCCCCAGCCACGCGCGTTGGTCGG GGCCAAAGTCATAGCGCA GGCGCTGTGAGATTCGCGGGCCGCCCTGAAGCGCGGCCCGGATGGCCTGGCCCAGGGCCC GGAGGCACGCCAGATGTA TGCGCGCGGTAAAGGCGACCTCGGCGGCGATGTCAAAGGGCGGCAGGACGGGGCGCGGGT GGCGCAGGGGCACCTCGA GCGCGGGAAAGCGGAGCAGCAGCTCCGCCTGCCCAGCGGGAGACAGCTGGTGGGGGCGCA CGACGCGTTCTGCGGCGC AGGCCTCGGTCAGGGCCGTGGCCAGCGCCGAGGACAGCAGCGGAGGGCGGGCGCGTCGCC CGCCCCACGCCACTGAGT TCTCGTAGGAGACGACGACGAAGCGCTGCTTGGTTCCGTAGTGGTGGCGCAGGACCACGG AGATAGAACGACGGCTCC ACAGCCAGTCCGGCCGGTCGCCGCCGGCCAGGGCTTCCCATCCGCGATCCAACCACTCGA CCAGCGACCGCGGCTTTG TGGTACCAGGGGTAAGGGTTAGAACGTCGTTCAGGATGTCCTCGCCCCCGGGCCCGTGGG GCGCTGGGGCCACAAAGC GGCCCCCGCCGGGGGGCTCCAGACCCGCCAGCACCGCATCTGCGTCAGCCGCCCCCATGG CGCCCCCGCTGACGGCCT GGTGAACCAGGGCGCCCTGGCGGAGCCCCGATGCAACGCCACAGGCCGCACGCCCGGTCC GAGCGCGGACCGGGTGGC GGCGGGTGACGTCCTGCACTGCCCGCTGAACCAACGCGAGGATCTCCTCGTTCTCCTGTG CGATGGACACGTCCTGGG CCGCGGTCGTGTCGCCGCCGGGGGCCGTCAGCTGCTCCTCCGGGGAGATGGGGGGGTCGG ACGCCCCGACGATGGGCG GGTCTGCGGGCGCCCCCGCGTGGGGCCGGGCCAAGGGCTGCGGACGCGGGGACGCGCTTT CCCCCAGACCCATGGACA GGTGGGCCGCGGCCTCCTTCGCGGCCGGCGGGGCGGCGGCGCCAAGCAGAGCGACGTAGC GGCACAAATGCCGACAGA CGCGCATGATGCGCGTGCTGTCGGCCGCGTAGCGCGTGTTGGGGGGGACGAGCTCGTCGT AACTAAACAGAATCACGC GGGCACAGCTCGCCCCCGAGCCCCACGCGAGGCGCAGCGCCGCCACGGCGTACGGGTCAT AGACGCCCTGCGCGTCAC ACACCACGGGCAGGGAGACGAACAACCCCCCGGCGCTGGACGCACGCGGAAGGAGGCCAG GGTGTGCCGGCACGACGG GGGCCAGAAGCTCCCCCACCGCATCCGCGGGCACGTAGGCGGCAAACGCCGTGCACCACG GGGTACAGTCGCCGGTGG CATGAGCCCGAGTCTGGATTTCGACCTGGAAGTTTGCGGCCGTCCCGAGTCCGGGGCGGC CGCGCATCAGGGCGGCCA GAGGGATTCCCGCGGCCGCCAGGCACTCGCTGGATATGATGACGTGAACCAAAGACGAGG GCCGACCCGGGCCGTGGC CGAGATCGTACTGGACCTCGTTGGCCAAGTGCGCGTTCATGGTTCGGGGTGGGTGTGGGT GTGTAGGCGATGCGGGTC CCCCGAGTCCGCGGGAAGGGCGTGGGTTTGGCGCGCGTATGCGTATTCGCCAACGGAGGC GTGCGTGCTTATGCGCGG CGCGTTTCTTCTGTCTCCAGGGAATCCGAGGCCAGGACTTTAACCTGCTCTTTGTCGACG AGGCCAACTTTATTCGCC CGGATGCGGTCCAGACGATTATGGGCTTTCTCAACCAGGCCAACTGCAAGATTATCTTCG TGTCGTCCACCAACACCG GGAAGGCCAGTACGAGCTTTTTGTACAACCTCCGCGGGGCCGCCGACGAGCTTCTCAACG TGGTGACCTATATATGCG ATGATCACATGCCGAGGGTGGTGACGCACACAAACGCCACGGCCTGTTCTTGTTATATCC TCAACAAGCCCGTTTTCA TCACGATGGACGGGGCGGTTCGCCGGACCGCCGATTTGTTTCTGGCCGATTCCTTCATGC AGGAGATCATCGGGGGCC AGGCCAGGGAGACCGGCGACGACCGGCCCGTTCTGACCAAGTCTGCGGGGGAGCGGTTTC TGTTGTACCGCCCCTCGA CCACCACCAACAGCGGCCTCATGGCCCCCGATTTGTACGTGTACGTGGATCCCGCGTTCA CGGCCAACACCCGAGCCT CCGGGACCGGCGTCGCTGTCGTCGGGCGGTACCGCGACGATTATATCATCTTTGCCCTGG AGCACTTTTTTCTCCGCG CGCTCACGGGCTCGGCCCCCGCCGACATCGCCCGCTGCGTCGTCCACAGTCTGACGCAGG TCCTGGCCCTGCATCCCG GGGCGTTTCGCGGCGTCCGGGTGGCGGTCGAGGGAAATAGCAGCCAGGACTCGGCCGTCG CCATCGCCACGCACGTGC ACACAGAGATGCACCGCCTACTGGCCTCGGAGGGGGCCGACGCGGGCTCGGGCCCCGAGC TTCTCTTCTACCACTGCG AGCCTCCCGGGAGCGCGGTGCTGTACCCCTTTTTCCTGCTCAACAAACAGAAGACGCCCG CCTTTGAACACTTTATTA AAAAGTTTAACTCCGGGGGCGTCATGGCCTCCCAGGAGATCGTTTCCGCGACGGTGCGCC TGCAGACCGACCCGGTCG AGTATCTGCTCGAGCAGCTGAATAACCTCACCGAAACCGTCTCCCCCAACACTGACGTCC GTACGTATTCCGGAAAAC GGAACGGCGCCTCGGATGACCTTATGGTCGCCGTCATTATGGCCATCTACCTTGCGGCCC AGGCCGGACCTCCGCACA CATTCGCTCCCATCACACGCGTTTCGTGAGCGCCCAATAAACACACCCAGGTATGCTACG CACGACCACGGTGTCGCC TGTTAAGGGGGGGGAAGGGGGTGTTGGCGGGAAGCGTGGGAACACGGGGGATTCTCTCAC GACCGGCACCAGTACCAC CCCCCTGT GAACAC AGAAAC C CAAC C C AAAT C C C AT AAAC AT AC GAC AC ACAG G CAT AT T T T G GAAT TTCTTGGGTTT TTATTTATTTAGGTATGCTGGGGTTTCTCCCTGGATGCCCACCCCCCACCCCCCCGTGGG TCTAGCCGGGCCTTAGGG ATAGCGTATAACGGGGGCCATGTCTCCGGACCGCACAACGGCCGCGCCGTCAAAGGTGCA CACCCGAACCACGGGAGC CAGGGCCAAGGTGTCTCCTAGTTGGCCCGCGTGGGTCAGCCAGGCGACGAGCGCCTCGTA AAGCGGCAGCCTTCGCTC TCCATCCTGCACCAGGGCCGGGGCTTCGGGGTGAATGAGCTGGGCGGCCTCCCGCGTGAC ACTCTGCATCTGCAGGAG AGCGTTCACGTACCCGTCCTGGGCACTTAGCGCAAAGAGCCGGGGGATTAGCGTAAGGAT GATGGTGGTTCCCTCCGT GATCGAGTAAACCATGTTAAGGACCAGCGATCGCAGCTCGGCGTTTACGGGACCGAGTTG TTGGACGTCCGCCAGCAG CGAGAGGCGACTCCCGTTGTAGTACAGCACGTTGAGGTCTGGCAGCCCTCCGGGGTTTCT GGGGCTGGGGTTCAGGTC CCGGATGCCCCTGGCCACGAGCCGCGCCACGATTTCGCGCGCCAGGGGCGATGGAAGCGG AACGGGAAACCGCAACGT GAGGTCCAGCGAATCCAGGCGCACGTCCGTCGCTTGGCCCTCGAACACGGGCGGGACGAG GCTGATGGGGTCCCCGTT ACAGAGATCTACGGGGGAGGTGTTGCGAAGGTTAACGGTGCCGGCGTGGGTGAGGCCCAC GTCCAGGGGGCAGGCGAC GATTCGCGTGGGAAGCACCCGGGTGATGACCGCGGGGAAGCGCCTTCGGTACGCCAGCAA CAACCCCAACGTGTCGGG ACTGACGCCTCCGGAGACGAAGGATTCGTGCGCCACGTCGGCCAGCGTCAGTTGCCGGCG GATGGTCGGCAGGAATAC CACCCGCCCTTCGCAGCGCTGCAGCGCCGCCGCATCGGGGCGCGAGATGCCCGAGGGTAT CGCGATGTCAGTTTCAAA GCCGTCCGCCAGCATGGCGCCGATCCACGCGGCAGGGAGTGCAGTGGTGGTTCGGGTGGC GGGAGGAGCGCGGTGGGG GTCAGCGGCGTAGCAGAGACGGGCGACCAACCTCGCATAGGACGGGGGGTGGGTCTTAGG GGGTTGGGAGGCGACAGG GACCCCAGAGCATGCGCGGGGAGGTCTGTCGGGCCCAGACGCACCGAGAGCGAATCCGTC CACGGAGTCCCGGTCTGG GTTTTATGGGGCCCGGCCCTCGGAATCGCGGCTTGTCGGCGGGGACAAAGGGGGCGGGGC TAGGGGGCTTGCGGAAAC AGAAGACGCGTGGGATAAAAGAATCGCACTACCCCAAGGAAGGGCGGGGCGGTTTATTAC AGAGCCAGTCCCTTGAGC GGGGATGCGTCATAGACGAGATACTGCGCGAAGTGGGTCTCCCGCGCGTGGGCTTCCCCG TTGCGGGCGCTGCGGAGG AGGGCGGGGTCGCTGGCGCAGGTGAGCGGGTAGGCCTCCTGAAACAGGCCACACGGGTCC TCCACGAGTTCGCGGCAC CCCGGGGGGCGCTTAAACTGTACGTCGCTGGCGGCGGTGGCCGTGGACACCGCCGAACCC GTCTCCACGATCAGGCGC TCCAGGCAGCGATGTTTGGCGGCGATGTCGGCCGACGTAAAGAACTTAAAGCAGGGGCTG AGCACCGGCGAGGCCCCG TTGAGGTGGTAGGCCCCGTTATAGAGCAGGTCCCCGTACGAAAATCGCTGCGACGCCCAC GGGTTGGCCGTGGCCGCA AAGGCCCGGGACGGGTCGCTCTGGCCGTGGTCGTACATGAGGGCGGTGACATCCCCCTCC TTGTCCCCCGCGTAAACG CCCCCGGCGGCGCGTCCCCGGGGGTTGCAGGGCCGGCGGAAGTAGTTGACGTCGGTCGAC ACGGGGGTGGCGATAAAC TCACACACGGCGTCCTGGCCGTGGTCCATCCCTGCGCGCCGCGGCACCTGGGCGCACCCG AACACGGGGACGGGCTGG GCCGGCCCCAGGCGGTTTCCCGCCACGACCGCGTTCCGCAGGTACACGGCTGCCGCGTTG TCCAGGAGAGGGGGAGCC CCGCGGCCCAGGTAAAAGTTTTGGGGAAGGTTGCCCATGTCGGTGACGGGGTTGCGGACG GTTGCCGTGGCCACGACG GCGGTGTAGCCCACGCCCAGGTCCACGTTCCCGCGCGGCTGGGTGAGCGTGAAGTTTACC CCCCCGCCAGTTTCGTGC CGGGCCACCTGGAGCTGGCCCAGGAAGTACGCCTCCGACGCGCGCTCCGAGAACAGCATG TTCTCAGTCACAAAGCGG TCCTGTCGGACGACGGTGAACCCAAACCCGGGATGGAGGCCCGTCTTGAGCTGATGATGC AAGGCCACGGGACTGATC TTGAAGTACCCCGCCATGAGCGCGTAGGTCAGCGCGTTCTCCCCGGCCGCGCTCTCGCGG ACGTGCTGCACGACGGGC TGTCGGATCGACGAAAAGTAGTTGGCCCCCAGAGCCGGGGGGACCAGGGGGACCTGCCGC GACAGGTCGCGCAGGGCC GGGGGGAAATTGGGCGCGTTCGCCACGTGGTCGGCCCCGGCGAACAGCGCGTTGACGGGA AGGGGGTAAAAATAGTCG CCATTTTGGATGGTATGGTCCAGATGCTGGGGGGCCATCAGCAGGATTCCGGCGTGCAAC GCCCCGTCGAATATGCGC ATGTTGGTGGTGGACGCGGTGTTGGCGCCCGCGTCGGGCGCCGCCGAGCAGAGCAGCGCC GTTGTGCGTTCGGCCATG TTGTGGGCCAGCACCTGCAGCGTGAGCATGGCGGGCCCGTCCACTACCACGCGCCCGTTG TGAAACATGGCGTTGACC GTGTTGGCCACCAGATTGGCCGGGTGCAGGGGGTGCGCGGGGTCCGTCACGGGGTCGCTG GGGCACTCCTCGCCGGGG GCGATCTCCGGGACCACCATGTTCTGCAGGGTGGCGTATACGCGGTCGAAGCGAACCCCC GCGGTGCAGCAGCGGCCC CGCGAGAAGGCGGGCACCATCACGTAGTAGTAAATCTTGTGGTGCACGGTCCAGTCCGCC CCCCGGTGCGGCCGGTCA TCCGCGGCGTCCGCGGCTCGGGCCTGGGTGTTGTGCAGCAGCTGGCCGTCGTTGCGGTTG AAGTCCGCGGTCGCCACG TTACATGCCGCCGCGTACACGGGGTCGTGGCCCCCCGCGCTAACCCGGCAGTCGCGATGG CGGTCCAGGGCCGCGCGC CGCATCAGGGCGTCACAGTCCCACACGAGGGGTGGCAGCAGCGCCGGGTCTCGCATTAGG TGATTCAGCTCGGCTTGC GCCTGCCCGCCCAGCTCCGGGCCGGTCAGGGTAAAGTCATCAACCAGCTGGGCCAGGGCC TCGACGTGCGCCACCAGG TCCCGGTACACGGCCATGCACTCCTCGGGAAGGTCTCCCCCGAGGTAGGTCACGACGTAC GAGACCAGCGAGTAGTCG TTCACGAACGCCGCGCACCGCGTGTTGTTCCAGTAGCTGGTGATGCACTGGACAACGAGC CGGGCCAGGGCGCAGAAG ACGTGCTCGCTGCCGTGTATGGCGGCCTGCAGCAGGTAAAACACCGCCGGGTAGTTGCGG TCGTCGAACGCCCCGCGA ACGGCGGCGATGGTGGCGGGGGCCATGGCGTGGCGTCCCACCCCCAGCTCCAGGCCCCGG GCGTCCCGGAACGCCGCC GGACATAGCGCCAGGGGCAAGTTGCCGTTCACCACGCGCCAGGTGGCCTGGATCTCCCCC GGGCCGGCCGGGGGAACG TCCCCCCCCGGCAGCTCCACGTCGGCCACCCCCACGAAGAAGTCGAACGCGGGGTGCAGC TCAAGAGCCAGGTTGGCG TTGTCGGGCTGCATAAACTGCTCCGGGGTCATCTGGCCTTCCGCGACCCATCGGACCCGC CCGTGGGCCAGGCGCTGC CCCCAGGCGTTCAAAAACAGCTGCTGCATGTCTGCGGCGGGGCCGGCCGGGGCCGCCACG TACGCCCCGTACGGATTG GCGGCTTCGACGGGGTCGCGGTTAAGGCCCCCGACCGCCGCGTCAACGTTCATCAGCGAA GGGTGGCACACGGTCCCG ATCGCGTGTTCCAGAGACAGGCGCAGCACCTGGCGGTCCTTCCCCCAAAAAAACAGCTGG CGGGGCGGGAAGGCGCGG GGATCCGGGTGGCCGGGGGCGGGGACTAGGTCCCCGGCGTGCGCGGCAAACCGTTCCATG ACCGGATTGAACAGGCCC AGGGGCAGGACGAACGTCAGGTCCATGGCGCCCACCAGGGGGTAGGGAACGTTGGTGGCG GCGTAGATGCGCTTCTCC AGGGCCTCCAGAAAGACCAGCTTCTCGCCGATGGACACCAGATCCGCGCGCACGCGCGTC GTCTGGGGGGCGCTCTCG AGCTCGTCCAGCGTCTGCCGGTTCAGGTCGAGCTGCTCCTCCTGCATCTCCAGCAGGTGG CGGCCCACGTCGTCCAGA CTTCGCACGGCCTTGCCCATCACGAGCGCCGTGACCAGGTTGGCCCCGTTCAGGACCATC TCGCCGTACGTCACCGGC ACGTCGGCTTCGGTGTCCTCCACTTTCAGGAAGGACTGCAGGAGGCGCTGTTTGATCGGG GCTGTGGTGACTAGCACC CCGTCGACCGGCCGCCCGCGCGTGTCGGCATGCGTCAGACGGGGCACGGCCACGGAGGGC TGCGTGGCCGTGGTGAGG TCCACGAGCCAGGCCTCGACGGCCTCCCGGCGGTGGCCCGCCTTGCCCAGGAAAAAGCTC GTCTCGCAGAAGCTTCGC TTTAGCTCGGCGACCAGGGTCGCCCGGGCCACCCTGGTGGCCAGGCGGCCGTTGTCCAGG TATCGTTGCATCGGCAAC AACAAAGCCAGGGGCGGCGCCTTTTCCAGCAGCACGTGCAGCATCTGGTCGGCCGTGCCG CGCTCAAACGCCCCGAGG ACGGCCTGGACGTTGCGAGCGAGCTGTTGGATGGCGCGCAACTGGCGATGCGCGCTGATA CCCGTCCCGTCCAGGGCC TCCCCCGTGAGCAGGGCGATGGCCTCGGTGGCCAGGCTGAAGGCGGCGTTCAGGGCCCGG CGGTCGATAATCTTGGTC ATGTAATTGTGTGTGGGTTGCTCGATGGGGTGCGGGCCGTCGCGGGCAATCAGCGGCTGG TGGACCTCGAACTGTACG CGCCCCTCGTTCATGTAGGCCAGCTCCGGAAACTTGGTACACACGCACGCCACCGACAAC CCGAGCTCCAGAAAGCGC ACGAGCGACAGGGTGTTGCAATACGACCCCAGCAGGGCGTCGAACTCGACGTCGTACAGG CTGTTTGCATCGGAGCGC ACGCGGGAAAAAAAATCGAACAGGCGTCGATGCGACGCCACCTCGATCGTGCTAAGGAGG GACCCGGTCGGCACCATG GCCGCGGCATACCGGTATCCCGGAGGGTCGCGGTTGGGAGCGGCCATAGGGTCGCGTGGA GATCGGCTGTCTCTAGCG ATATTGGCCCGGGGAGGCTAAGATCCACCCCAACGCCCGGCCACCCGTGTACGTGCCCGA CGGCCCAAGGTCCACCGA AAGACACGACGGACCCGGACCCAAAGAGGCGGGGGATGCTGTGTGAGAGGCCGGGTGTCG GTCGGGGGGGAAAGGCAC CGGGAGAAGGCTGCGGCCTCGTTCCAGGAGAACCCAGTGTCCCCAACAGACCCGGGGACG TGGGATCCCCGGCCTTAT ATACCCCCCCCCCCGCCCCACCCCCGTTAGAACGCGACGGGTGCATTCAAGATGGCCCTG GTCCAAAAGCGTGCCAGG AAGAAATTGGCAGAGGCGGCAAAGCTGTCCGCCGCCGCCACCCACATCGAGGCCCCGGCC ACACAGGCTATCCCCAGG GCCCGTGTGCGCAGGGGATCGGTGGGTGGCAGCATTTGGTTGGTGGCGATAAAGTGGAAA AGCCCGTCCGGACTGAAG GTCTCGTGGGCGGCGGCGAACAAGGCACACAGGGCCGTGCCTCCCAAAAACATGGACATC CCCCAAAACACGGGCGCC GACAACGGCAGACGATCCCTCTTGATGTTAACGTACAGGAGGAGCGCCCGCACCGCCCAC GTAACGTAGTAGCCGACG ATGGCGGCCAGGATACAGGCCGGCGCCACCACCCTTCCGGTCAGCCCGTAATACATGCCC GCTGCCACCATCTCCAAC GGCTTCAGGACCAAAAACGACCAAAGGAACAGAATCACGCGCTTTGAAAAGACCGGCTGG GTATGGGGCGGAAGACGC GAGTATGCCGAACTGACAAAAAAATCAGAGGTGCCGTACGAGGACAATGAAAACTGTTCC TCCAGCGGCAGTTCTCCC TCCTCCCCCCCGAAGGCGGCCTCGTCGACCAGATCTCGATCCACCAGAGGAAGGTCATCC CGCATGGTCATGGGGTGT GCGGTGGAGGTGGGGAGACCGAAACCGCAAAGGGTCGCTTACGTCAGCAGGATCCCGAGA TCAAAGACACCCGGGTTC TTGCACAAACACCACCCGGGTTGCATCCGCGGAGGCGAGTGTTTTGATAAGGCCGTTCCG CGCCTTGATATAACCTTT GATGTTGACCACAAAACCCGGAATTTACGCCTACGCCCCAATGCCCACGCAAGATGAGGT AGGTAACCCCCCCGTGGG TGTGACGTTGCGTTTAGTTCATTGGAGGCCAAGGGGAAAAATGGGGTGGGGAGGAAACGG AAAACCCAGTAGGCCGTG TCGGGAACACGCCCGGGGTTGTCCTCAAAAGGCAGGGTCCATACTACGGAAGCCGTCGTT GTATTCGAGACCTGCCTG TGCGACGCACGTCGGGGTTGCCTGTGTCCGGTTCGGCCCCCACCGCGTGCGGCACGCACG AGGACGAGTCCGCGTGCT TTATTGGCGTTCCAAGCGTTGCCCTCCAGTTTCTGTTGTCGGTGTTCCCCCATACCCACG CCCACATCCACCGTAGGG GGCCTCTGGGCCGTGTTACGTCGCCGCCCGCGATGGAGCTTAGCTACGCCACCACCATGC ACTACCGGGACGTTGTGT TTTACGTCACAACGGACCGAAACCGGGCCTACTTTGTGTGCGGGGGGTGTGTTTATTCCG TGGGGCGGCCGTGTGCCT CGCAGCCCGGGGAGATTGCCAAGTTTGGTCTGGTCGTTCGAGGGACAGGCCCAGACGACC GCGTGGTCGCCAACTATG TACGAAGCGAACTCCGACAACGCGGCCTGCAGGACGTGCGTCCCATTGGGGAGGACGAGG TGTTTCTGGACAGCGTGT GTCTTCTAAACCCGAACGTGAGCTCCGAGCTGGATGTGATTAACACGAACGACGTGGAAG TGCTGGACGAATGTCTGG CCGAGTACTGCACCTCGCTGCGAACCAGCCCGGGTGTGCTAATATCCGGGCTGCGCGTGC GGGCGCAAGACAGAATCA TCGAGTTGTTTGAACACCCAACGATAGTCAACGTTTCCTCGCACTTTGTGTATACCCCGT CCCCATACGTGTTCGCCC TGGCCCAGGCGCACCTCCCCCGGCTCCCGAGCTCGCTGGAGGCCCTGGTGAGCGGCCTGT TTGACGGCATCCCCGCCC CACGCCAGCCACTTGACGCCCACAACCCGCGCACGGATGTGGTTATCACGGGCCGCCGCG CCCCACGACCCATCGCCG GGTCGGGGGCGGGGTCGGGGGGCGCGGGCGCCAAGCGGGCCACCGTCAGCGAGTTCGTGC AAGTCAAACACATTGACC GCGTGGGCCCCGCTGGCGTTTCGCCGGCGCCTCCGCCAAACAACACCGACTCGAGTTCCC TGGTGCCCGGGGCCCAGG ATTCCGCCCCGCCCGGCCCCACGCTAAGGGAGCTGTGGTGGGTGTTTTATGCCGCAGACC GGGCGCTGGAGGAGCCCC GCGCCGACTCTGGCCTCACCCGCGAGGAGGTACGTGCCGTACGTGGGTTCCGGGAGCAGG CGTGGAAACTGTTTGGCT CCGCGGGGGCCCCGCGGGCGTTTATCGGGGCCGCGTTGGGCCTGAGCCCCCTCCAAAAGC TGGCCGTTTACTACTATA TCATCCACCGAGAGAGGCGCCTGTCCCCCTTCCCCGCGCTAGTCCGGCTCGTAGGCCGGT ACACACAGCGCCACGGCC TGTACGTCCCTCGGCCCGACGACCCAGTCTTGGCCGATGCCATCAACGGGCTGGTTCGCG ACGCGCTGGCGGCCGGAA CCACAGCCGAGCAGCTCCTCATGTTCGACCTTCTCCCCCCAAAGGACGTGCCGGTGGGAA GCGACGTGCAGGCCGACA GCACCGCTCTGCTGCGCTTTATAGAATCGCAACGTCTCGCCGTCCCCGGGGGGGTGATCT CCCCCGAGCACGTCGCGT ACCTTGGTGCGTTCCTGAGCGTGCTGTACGCTGGCCGCGGGCGCATGTCCGCAGCAACGC ACACCGCGCGGCTGACAG GGGTGACCTCCCTGGTGCTAGCGGTGGGTGACGTGGACCGTCTTTCCGCGTTTGACCGCG GAGCGGCGGGCGCGGCCA GCCGCACGCGGGCCGCCGGGTACCTGGATGTGCTTCTTACCGTTCGTCTCGCTCGCTCCA AACACGGACAGTCTGTGT AACAGACCCCAATAAACGTATGTCGCTACCACACCCTTGTGTGTCAATGGACGCCTCTCC GGGGGGGAGAGGGAAAAC AAAGAGGGGCTGGGGGAGCGGCACCACTGGGGCCTGAACAAACAAACCACAGACACGGTT ACAGTTTATTCGGTCGGG CGGATAAACGGCCGAAGCCACGCCCCCTTTATTCGCGTCTCCAAAAAAACGGGACACTTG TCCGGAGAACCTTTAGGA TGCCAGCCAGGGCGGCGGTAATCATAACCACGCCCAGCGCAGAGGCGGCCAGAAACCCGG GCGCAATTGCGGCCACGG GCTGCGTGTCAAAGGCTAGCAAATGAATGACGGTTCCGTTTGGAAATAGCAACAAGGCCG TGGACGGCACGTCGCTCG AAAACACGCTCGGGGCGCCCTCCGTCGGCCCGGCGGCGATTTGCTGCTGTGTGTTGTCCG TATCCACCAGCAACACAG ACATGACCTCCCCGGCTGGGGTGTAGCGCATAAACACGGCCCCCACGAGCCCCAGGTCGC GCTGGTTTTGGGTGCGCA CCAGCCGCTTGGACTCGATATCCCGGGTGGAGCCTTCGCATGTCGCGGTGAGGTAGGTTA GGAACAGTGGGCGTCGGA CGTCGACGCCGGTGAGCTTGTAGCCGATCCCCCGGGGCAGAGGGGAGTGGGTGACGACGT AGCTGGCGTTGTGGGTGA TGGGTACCAGGATCCGTGGCTCGACGTTGGCAGACTGCCCCCCGCACCGATGTGAGGCCT CAGGGACGAAGGCGCGGA TCAGGGCGTTGTAGTGTGCCCAGCGCGTCAGGGTCGAGGCGAGGCCGTGGGTCTGCTGGG CCAGGACTTCGACCGGGG TCTCGGATCGGGTGGCTTGAGCCAGCGCGTCCAGGATAAACACGCTCTCGTCTAGATCAA AGCGCAGGGAGGCCGCGC ATGGCGAAAAGTGGTCCGGAAGCCAAAAGAGGGTTTTCTGGTGGTCGGCCCGGGCCAGCG CGGTCCGGAGGTCGGCGT TGGTCGCTGCGGCGACGTCGGACGTACACAGGGCCGATGCTATCAGAAGGCTCCGGCGGG CGCGTTCCCGCTGCACCG CCGAGGGGACGCCCGCCAAGAACGGCTGCCGGAGGACAGCCGAGGCGTAAAATAGCGCCC GGTGGACGACCGGGGTGG TCAGCACGCGGCCCCCTAGAAACTCGGCATACAGGGCGTCGATGAGATGGGCTGCGCTGG GCGCCACTGCGTCGTACG CCGAGGGGCTATCCAGCACGAAGGCCAGCTGATAGCCCAGCGCGTGTAATGCCAAGCTCT GTTCGCGCTCCAGAATCT CGGCCACCAGGTGCTGGAGCCGAGCCTCTAGCTGCAGGCGGGCCGTGGGATCCAAGACTG ACACATTAAAAAACACAG AATCCGCGGCACAGCCCGCGGCCCCGCGGGCGGCCAACCCGGCAAGCGCGCGCGAGTGGG CCAAAAAGCCTAGCAGGT CGGAGAGGCAGACCGCGCCGTTTGCGTGGGCGGCGTTCACGAAAGCAAAACCCGACGTCG CGAGCAGCCCCGTTAGGC GCCAGAAGAGAGGGGGGCGCGGGCCCTGCTCGGCGCCCGCGTCCCCCGAGAAAAACTCCG CGTATGCCCGCGACAGGA ACTGGGCGTAGTTCGTGCCCTCCTCCGGGTAGCCGCCCACGCGGCGGAGGGCGTCCAGCG CGGAGCCGTTGTCGGCCC GCGTCAGGGACCCTAGGACAAAGACCCGATACCGGGGGCCGCCCGGGGGCCCGGGAAGAG CCCCCGGGGGGTTTTCGT CCGCGGGGTCCCCGACCCGATCTAGCGTCTGGCCCGCGGGGACCACCATCACTTCCACCG GAGGGCTGTCGTGCATGG ATATCACGAGCCCCATGAATTCCCGCCCGTAGCGCGCGCGCACCAGCGCGGCATCGCACC CGAGCACCAGCTCCCCCG TCGTCCAGATGCCCACGGGCCACGTCGAGGCCGACGGGGAGAAATACACGTACCTACCTG GGGATCTCAACAGGCCCC GGGTGGCCAACCAGGTCGTGGACGCGTTGTGCAGGTGCGTGATGTCCAGCTCCGTCGTCG GGTGCCGCCGGGCCCCAA CCGGCGGTCGGGGGGGCGGTGTATCACGCGGCCCGCTTGGGTGGCTCGCCGTCGCCACGT TGTCTCCCCGCGGGAACG TCAGGGCCTCGGGGTCAGGGACGGCCGAAAACGTTACCCAGGCCCGGGAACGCAGCAACA CGGAGGCGACTGGATTGT ACAAGAGACCCTTAAGGGGGGCGACCGAGGGGGGAGGCTGGGCGGTCGGCTCGACCGTGG TGGGGGCGGGCAGGCTCG CGTTCGGGGGCCGGCCGAGCAGGTAGGTCTTCGGGATGTAAAGCAGCTGGCCGGGGTCCC GCGGAAACTCGGCCGTGG TGACCAATACAAAACAAAAGCGCTCCTCGTACCAGCGAAGAAGGGGCAGAGATGCCGTAG TCAGGTTTAGTTCGTCCG GCGGCGCCAGAAATCCGCGCGGTGGTTTTTGGGGGTCGGGGGTGTTTGGCAGCCACAGAC GCCCGGTGTTTGTGTCGC GCCAGTACATGCGGTCCATGCCCAGGCCATCCAAAAACCATGGGTCTGTCTGCTCAGTCC AGTCGTGGACCTGACCCC ACGCAACGCCCAAAATAATAACCCCCACGAACCATAAACCATTCCCCATGGGGGACCCCG TCCCTAACCCACGGGGCC CGTGGCTATGGCAGGGCTTGCCGCCCCGACGTTGGCTGCGAGCCCTGGGCCTTCACCCGA ACTTGGGGGGTGGGGTGG GGAAAAGGAAGAAACGCGGGCGTATTGGCCCCAATGGGGTCTCGGTGGGGTATCGACAGA GTGCCAGCCCTGGGACCG AACCCCGCGTTTATGAACAAACGACCCAACACCCGTGCGTTTTATTCTGTCTTTTTATTG CCGTCATAGCGCGGGTTC CTTCCGGTATTGTCTCCTTCCGTGTTTCAGTTAGCCTCCCCCATCTCCCGGGCAAACGTG CGCGCCAGGTCGCAGATC GTCGGTATGGAGCCGGGGGTGGTGACGTGGGTCTGGACCATCCCGGAGGTAAGTTGCAGC AGGGCGTCCCGGCAGCCG GCGGGCGATTGGTCGTAATCCAGGATAAAGACGTGCATGGGACGGAGGCGTTTGGCCAAG ACGTCCAAGGCCCAGGCA AACACGTTGTACAGGTCGCCGTTGGGGGCCAGCAACTCGGGGGCCCGAAACAGGGTAAAT AACGTGTCCCCGATATGG GGTCGTGGGCCCGCGTTGCTCTGGGGCTCGGCACCCTGGGGCGGCACGGCCGTCCCCGAA AGCTGTCCCCAATCCTCC CGCCACGACCCGCCGCCCTGCAGATACCGCACCGTATTGGCAAGCAGCCCGTAAACGCGG CGAATCGCGGCCAGCATA GCCAGGTCAAGCCGCTCGCCGGGGCGCTGGCGTTTGGCCAGGCGGTCGATGTGTCTGTCC TCCGGAAGGGCCCCCAAC ACGATGTTTGTGCCGGGCAAGGTCGGCGGGATGAGGGCCACGAACGCCAGCACGGCCTGG GGGGTCATGCTGCCCATA AGGTATCGCGCGGCCGGGTAGCACAGGAGGGCGGCGATGGGATGGCGGTCGAAGATGAGG GTGAGGGCCGGGGGCGGG GCATGTGAGCTCCCAGCCTCCCCCCCGATATGAGGAGCCAGAACGGCGTCGGTCACGGCA TAAGGCATGCCCATTGTT ATCTGGGCGCTTGTCATTACCACCGCCGCGTCCCCGGCCGATATCTCACCCTGGTCGAGG CGGTGTTGTGTGGTGTAG ATGTTCGCGATTGTCTCGGAAGCCCCCAGCACCTGCCAGTAAGTCATCGGCTCGGGTACG TAGACGATATCGTCGCGC GAACCCAGGGCCACCAGCAGTTGCGTGGTGGTGGTTTTCCCCATCCCGTGAGGACCGTCT ATATAAACCCGCAGTAGC GTGGGCATTTTCTGCTCCAGGCGGACTTCCGTGGCTTCTTGCTGCCGGCGAGGGCGCAAC GCCGTACGTCGGTTGCTA TGGCCGCGAGAACGCGCAGCCTGGTCGAACGCAGACGCGTGTTGATGGCAGGGGTACGAA GCCATACGCGCTTCTACA AGGCGCTTGCCGAAGAGGTGCGGGAGTTTCACGCCACCAAGATCTGCGGCACGCTGTTGA CGCTGTTAAGCGGGTCGC TGCAGGGTCGCTCGGTGTTCGAGGCCACACGCGTCACCTTAATATGCGAAGTGGACCTGG GACCGCGCCGCCCCGACT GCATCTGCGTGTTCGAATTCGCCAATGACAAGACGCTGGGCGGGGTTTGTGTCATCATAG AACTAAAGACATGCAAAT ATATTTCTTCCGGGGACACCGCCAGCAAACGCGAGCAACGGGCCACGGGGATGAAGCAGC TGCGCCACTCCCTGAAGC TCCTGCAGTCCCTCGCGCCTCCGGGTGACAAGATAGTGTACCTGTGCCCCGTCCTGGTGT TTGTCGCCCAACGGACGC TCCGCGTCAGCCGCGTGACCCGGCTCGTCCCGCAGAAGGTCTCCGGTAATATCACCGCAG TCGTGCGGATGCTCCAGA GCCTGTCCACGTATACGGTCCCCATGGAGCCTAGGACCCAGCGAGCCCGTCGCCGCCGCG GCGGCGCCGCCCGGGGGT CTGCGAGCAGACCGAAAAGGTCACACTCTGGGGCGCGCGACCCGCCCGAGTCAGCGGCCC GCCAATTACCACCCGCCG ACCAAACCCCCGCCTCCACGGAGGGCGGGGGGGTGCTTAAGAGGATCGCGGCGCTCTTCT GCGTGCCCGTGGCCACCA AGACCAAACCCCGAGCCGCCTCCGAATGAGAGTGTTTCGTTCCTTCCCCCTCCCCCCGCG TCAGACAAACCCTAACCA CCGCTTAAGCGGCCCCCGCGAGGTCCGAAGACTCATTTGGATCCGGCGGGAGCCACCCGA CAACAGCCCCCGGGTTTT CCCACGCCAGACGCCGGTCCGCTGTGCCATCGCGCCCCCTCATCCCACCCCCCATCTTGT CCCCAAATAAAACAAGGT CTGGTAATTAGGACAACGACCGCAGTTCTCGTGTGTTATTTTCGCTCTCCGCCTCTCGCA GATGGACCCGTACTGCCC ATTTGACGCTCTGGACGTCTGGGAACACAGGCGCTTCATAGTCGCCGATTCCCGAAACTT CATCACCCCCGAGTTCCC CCGGGACTTTTGGATGTCGCCCGTCTTTAACCTCCCCCGGGAGACGGCGGCGGAGCAGGT GGTCGTCCTACAGGCCCA GCGCACAGCGGCTGCCGCTGCCCTGGAGAACGCCGCCATGCAGGCGGCCGAGCTCCCCGT CGATATCGAGCGCCGGTT ACGCCCGATCGAACGGAACGTGCACAAGATCGCAGGCGCCCTGGAGGCGCTGGAGACGGC GGCGGCCGCCGCCGAAGA GGCGGATGCCGCGCGCGGGGATGAGCCGGCGGGTGGGGGCGACGGGGGGGCGCCCCCGAG TCTGGCCGTCGCGGAGAT GGAGGTCCAGATCGTGCGCAACGACCCGCCGCTACGATACGACACCAACCTCCCCGTGGA TCTGCTACACATGGTGTA CGCGGGCCGCGGGGCGACCGGATCGTCGGGGGTGGTGTTCGGGACCTGGTACCGCACTAT CCAGGACCGCACCATCAC GGACTTTCCCCTGACCACCCGCAGTGCCGACTTTCGGGACGGCCGTATGTCCAAGACCTT CATGACGGCGCTGGTACT GTCCCTGCAGTCGTGCGGCCGGCTGTATGTGGGCCAGCGCCACTATTCCGCCTTCGAGTG CGCCGTGTTGTGTCTCTA CCTGCTGTACCGAAACACGCACGGGGCCGCCGACGATAGCGACCGCGCTCCGGTCACGTT CGGGGATCTGCTGGGCCG GCTGCCCCGCTACCTGGCGTGCCTGGCCGCGGTGATCGGGACCGAGGGCGGCCGGCCACA GTACCGCTACCGCGACGA CAAGCTCCCCAAGACGCAGTTCGCGGCCGGCGGGGGCCGCTACGAACACGGAGCGCTGGC GTCGCACATCGTGATCGC CACGCTGATGCACCACGGGGTGCTCCCGGCGGCCCCGGGGGACGTCCCCCGGGACGCGAG CACCCACGTTAACCCCGA CGGCGTGGCGCACCACGACGACATAAACCGCGCCGCCGCCGCGTTCCTCAGCCGGGGCCA CAACCTATTCCTGTGGGA GGACCAGACTCTGCTGCGGGCAACCGCGAACACCATAACGGCCCTGGGCGTTATCCAGCG GCTCCTCGCGAACGGCAA CGTGTACGCGGACCGCCTCAACAACCGCCTGCAGCTGGGCATGCTGATCCCCGGAGCCGT CCCTTCGGAGGCCATCAC CCGTGGGGCCTCCGGGTCCGACTCGGGGGCCATCAAGAGCGGAGACAACAATCTGGAGGC GCTATGTGCCAATTACGT GCTTCCGCTGTACCGGGCCGACCCGGCGGTCGAGCTGACCCAGCTGTTTCCCGGCCTGGC CGCCCTGTGTCTTGACGC CCAGGCGGGGCGGCCGGTCGGGTCGACGCGGCGGGTGGTGGATATGTCATCGGGGGCCCG CCAGGCGGCGCTGGTGCG CCTCACCGCCCTGGAACTCATCAACCGCACCCGCACAAACCCCACCCCCGTGGGGGAGGT TATCCACGCCCACGACGC CCTGGCGATCCAATACGAACAGGGGCTTGGCCTGCTGGCGCAGCAGGCACGCATTGGCTT GGGCTCCAACACCAAGCG TTTCTCCGCGTTCAACGTTAGCAGCGACTACGACATGTTGTACTTTTTATGTCTGGGGTT CATTCCACAGTACCTGTC GGCGGTTTAGTGGGTGGTGGGCGAGGGGGGAGGGGGCATTAGGGAGAAAGAACAAGAGCC TCCGTTGGGTTTTCTTTG TGCCTGTACTCAAAAGGTCATACCCCGTAAACGGCGGGCTCCAGTCCCGGCCCGGCGGTT GGCGTGAACGCAACGGCG GGAGCTGGGTTAGCGTTTAGTTTAGCATTCGCTCTCGCCTTTCCGCCCGCCCCCCGACCG TTGCGCCTTTTTTTTTTT CGTCCACCAAAGTCTCTGTGGGTGCGCGCATGACAGCCGATGCCCCGGGAGACCGGATGG AGGAGCCCCTGCCAGACA GGGCCGTGCCCATTTACGTGGCTGGGTTTTTGGCCCTGTATGACAGCGGGGACTCGGGCG AGTTGGCATTGGATCCGG ATACGGTGCGTGCGGCCCTGCCTCCGGATAACCCACTCCCGATTAACGTGGACCACCGCG CTGGCTGCGAGGTGGGGC GGGTGCTGGCCGTGGTCGACGACCCCCGCGGGCCGTTTTTTGTGGGACTGATCGCCTGCG TGCAACTGGAGCGCGTCC TCGAGACGGCCGCCAGCGCTGCGATTTTCGAGCGCCGCGGGCCGCCGCTCTCCCGGGAGG AGCGCCTGTTGTACCTGA TCACCAACTACCTGCCCTCGGTCTCCCTGGCCACAAAACGCCTGGGGGGCGAGGCGCACC CCGATCGCACGCTGTTCG CGCACGTCGCGCTGTGCGCGATCGGGCGGCGCCTCGGCACTATCGTCACCTACGACACCG GTCTCGACGCCGCCATCG CGCCCTTTCGCCACCTGTCGCCGGCGTCTCGCGAGGGGGCGCGGCGACTGGCCGCCGAGG CCGAGCTCGCGCTGTCCG GACGCACCTGGGCGCCCGGCGTGGAGGCGCTGACCCACACGCTGCTTTCCACCGCCGTTA ACAACATGATGCTGCGGG ACCGCTGGAGCCTGGTGGCCGAGCGGCGGCGGCAGGCCGGGATCGCCGGACACACCTACC TCCAGGCGAGCGAAAAAT TCAAAATGTGGGGGGCGGAGCCTGTTTCCGCGCCGGCGCGCGGGTATAAGAACGGGGCCC CGGAGTCCACGGACATAC CGCCCGGCTCGATCGCTGCCGCGCCGCAGGGTGACCGGTGCCCAATCGTCCGTCAGTGCG GGGTCGCCTCGCCCCCGG TACTGCCCCCCATGAACCCCGTTCCGGCATCGGGCACCCCGGCCCCCGCGCCGCCCGGCG ACGGGAGCTACCTGTGGA TCCCGGCCTCCCATTACAACCAGCTCGTCGCCGGCCACGCCGCGCCCCAACCCCAGCCGC ATTCCGCGTTTGGTTTCC CGGCTGCGGCGGGGGCCGTGGCCTATGGGCCTCACGGCGCGGGTCTTTCCCAGCATTACC CTCCCCACGTCGCCCATC AGTATCCCGGGGTGCTGTTCTCGGGACCCAGCCCACTCGAGGCGCAGATAGCCGCGTTGG TGGGGGCCATAGCCGCGG ACCGCCAGGCGGGCGGTCAGACGGCCGCGGGAGACCCTGGGGTCCGGGGGTCGGGAAAGC GTCGCCGGTACGAGGCGG GGCCGTCGGAGTCCTACTGCGACCAGGACGAACCGGACGCGGACTACCCGTACTACCCCG GGGAGGCTCGAGGCGGGC CGCGCGGGGTCGACTCTCGGCGCGCGGCCCGCCAGTCTCCCGGGACCAACGAGACCATCA CGGCGCTGATGGGGGCGG TGACGTCTCTGCAGCAGGAACTGGCGCACATGCGGGCTCGGACCAGCGCCCCCTATGGAA TGTACACGCCGGTGGCGC ACTATCGCCCTCAGGTGGGGGAGCCGGAACCAACAACGACCCACCCGGCCCTTTGTCCCC CGGAGGCCGTGTATCGCC CCCCACCACACAGCGCCCCCTACGGTCCTCCCCAGGGTCCGGCGTCCCATGCCCCCACTC CCCCGTATGCCCCAGCTG CCTGCCCGCCAGGCCCGCCACCGCCCCCATGTCCTTCCACCCAGACGCGCGCCCCTCTAC CGACGGAGCCCGCGTTCC CCCCCGCCGCCACCGGATCCCAACCGGAGGCATCCAACGCGGAGGCCGGGGCCCTTGTCA ACGCCAGCAGCGCAGCAC ACGTGGACGTTGACACGGCCCGCGCCGCCGATTTGTTCGTCTCTCAGATGATGGGGGCCC GCTGATTCGCCCCGGTCT TTGGTACCATGGGATGTCTTACTGTATATCTTTTTAAATAAACCAGGTAATACCAAATAA GACCCATTGGTGTATGTT CTTTTTTTATTGGGAGGCGCGGGTAGGCGGGTAGCTTTACAATGCAAAAACCTTCGACGT GGAGGAAGGCGTGGGGGG GGGGAATCGGCACTGACCAAGGGGGTCCGTTTTGTCACGGGAAAGGAAAGAGGAAACAGG CCGCGGACACCCGGGGGA GTTTATGTGTTCCCTTTTCTTTCTTCCCACACACACAAAAGGCGTACCAAACAAACAAAC CAAAAGATGCACATGCGG TTTAACACCCGTGGTTTTTATTTACAACAAACCCCCCGTCACAGGTCGTCCTCGTCGGCG TCACCGTCTTTGTTGGGA ACTTGGGTGTAGTTGGTGTTGCGGCGCTTGCGCATGACCATGTCGGTGACCTTGGCGCTG AGCAGCGCGCTCGTGCCC TTCTTCTTGGCCTTGTGTTCCGTGCGCTCCATGGCAGACACCAGGGCCATGTACCGTATC ATCTCCCGGGCCTCGGCT AGCTTGGCCTCGTCAAAGTCGCCGCCCTCCTCGCCCTCCCCGGACGCGTCCGGGTTGGTG GGGTTCTTGAGCTCCTTG GTGGTTAGCGGGTACAGGGCCTTCATGGGGTTGCTCTGCAGCCGCATGACGTAGCGAAAG GCGAAGAAAGCCGCCGCC AGGCCGGCCAGGACCAACAGACCCACGGCCAGCGCCCCAAAGGGGTTGGACATGAAGGAG GACACGCCCGACACGGCC GATACCACGCCGCCCACGATGCCCATCACCACCTTGCCGACCGCGCGCCCCAGGTCGCCC ATCCCCTCGAAGAACGCG CCCAGGCCCGCGAACATGGCGGCGTTGGCGTCGGCGTGGATGACCGTGTCGATGTCGGCG AAGCGCAGGTCGTGCAGC TGGTTGCGGCGCTGGACCTCCGTGTAGTCCAGCAGGCCGCTGTCCTTGATCTCGTGGCGG GTGTACACCTCCAGGGGG ACAAACTCGTGATCCTCCAGCATGGTGATGTTGAGGTCGATGAAGGTGCTGACGGTGGTG ATGTCGGCGCGGCTCAGC TGGTGGGAGTACGCGTACTCCTCGAAGTACACGTAGCCCCCGCCGAAGGTGAAGTAGCGC CGGTGTCCCACGGTGCAC GGCTCGATCGCATCGCGCGTCAGCCGCAGCTCGTTGTTCTCCCCCAGCTGCCCCTCGACC AACGGGCCCTGGTCTTCG TACCGAAAGCTGACCAGGGGGCGGCTGTAGCAGGCCCCGGGCCGCGAGCTGATGCGCATC GAGTTTTGGACGATCACG TTGTCCGCGGCGACCGGCACGCACGTGGAGACGGCCATCACGTCGCCGAGCATCCGCGCG CTCACCCGCCGGCCCACG GTGGCCGAGGCGATGGCGTTGGGGTTCAGCTTGCGGGCCTCGTTCCACAGGGTCAGCTCG TGATTCTGCAGCTCGCAC CACGCGATGGCAACGCGGCCCAACATATCGTTGACATGGCGCTGTATGTGGTTGTACGTA AACTGCAGCCGGGCGAAC TCGATGGAGGAGGTGGTCTTGATGCGCTCCACGGACGCGTTGGCGCTGGCCCCGGGCGGC GGGGGCGTGGGGTTTGGG GGCTTGCGGCTCTGCTCTCGGAGGTGTTCCCGCACGTACAGCTCCGCGAGCGTGTTGCTG AGAAGGGGCTGGTACGCG ATCAGAAAACCCCCATTGGCCAGGTAGTACTGCGGCTGGCCCACCTTGATGTGCGTCGCG TTGTACCTGCGGGCGAAG ATGCGGTCCATGGCGTCGCGGGCGTCCTTGCCGATGCAGTCCCCCAGGTCCACGCGCGAG AGCGGGTACTCGGTCAGG TTGGTGGTGAAGGTGGTGGATATGGCGTCGGAGGAGAATCGGAAGGAGCCGCCGTACTCG GAGCGCAGCATCTCGTCC ACCTCCTGCCACTTGGTCATGGTGCAGACCGACGGGCGCTTTGGCACCCAGTCCCAGGCC ACGGTGAACTTGGGGGTC GTGAGCAGGTTCCGGGTGGTCGGCGCCGTGGCCCGGGCCTTGGTGGTGAGGTCGCGCGCG TAGAAGCCGTCAACCTGC TTGAAGCGGTCGGCGGCGTAGCTGGTGTGTTCGGTGTGCGACCCCTCCCGGTAGCCGTAA AACGGGGACATGTACACA AAGTCGCCAGTCGCCAGCACAAACTCGTCGTACGGGTACACCGAGCGCGCGTCCACCTCC TCGACGATGCAGTTTACC GTCGTCCCGTACCGGTGGAACGCCTCCACCCGCGAGGGGTTGTACTTGAGGTCGGTGGTG TGCCAGCCCCGGCTCGTG CGGGTCGCGGCGTTGGCCGGTTTCAGCTCCATGTCGGTCTCGTGGTCGTCCCGGTGAAAC GCGGTGGTCTCCAGGTTG TTGCGCACGTACTTGGCCGTGGACCGACAGACCCCCTTGGCGTTGATCTTGTCGATCACC TCCTCGAAGGGGACGGGG GCGCGGTCCTCAAAGATCCCCATAAACTGGGAGTAGCGGTGGCCGAACCACACCTGCGAA ACGGTGACGTCTTTGTAG TACATGGTGGCCTTGAACTTGTACGGGGCGATGTTCTCCTTGAAGACCACCGCGATGCCC TCCGTGTAGTTCTGACCC TCGGGCCGGGTCGGGCAGCGGCGCGGCTGCTCGAACTGCACCACCGTGGCGCCCGTGGGG GGTGGGCACACGTAAAAG TTTGCATCGGTGTTCTCCGCCTTGATGTCCCGCAGGTGCTCGCGCAGGGTGGCGTGGCCC GCGGCGACGGTCGCGTTG TCGCCGGCGGGGCGCGGCGGCGGTGGGGGTTTCGGTTTTTTGTTCTTCTTCGGTTTCGTG TCCCCCGTTGGGGCGGGG CCAGGGGCGGGCGGCGCCGGAGTGGCAGGTCCCCCGTTCGCCGCCTGGGTCGCGGCCGCG ACCCCAGGCGTGCCGGGG GAACTCGGAGCCGCCGACGCCACCAGGACCCCCAGCGTCAACCCCAAGAGCGCCCATACG ACGAACCACCGGCACCCC CGCGCGGGGGCGCCCTGGCGCATGGCGGGACTACGGGGGCCCGTCGTGCCCCCCGTCAGG TAGCCTGGGGGCGAGGTG CTGGAGGACCGAGTAGAGGATCGAGAAAACGTCTCGGTCGTAGACCACGACCGACCGGGG GCCGATACAGCCGTCGGG GGCGCTCTCGACGATGGCCACCAGCGGACAGTCGGAGTCGTACGTGAGATATACGCCGGG CGGGTAACGGTAACGACC TTCGGAGGTCGGGCGGCTGCAGTCCGGGCGGCGCAACTCGAGCTCCCCGCACCGGTAGAC CGAGGCAAAGAGTGTGGT GGCGATAATCAGCTCGCGAATATATCGCCAGGCGGCGCGCTGAGTGGGCGTTATTCCGGA AATGCCGTCAAAACAGTA AAACCTCTGAAATTCGCTGACGGCCCAATCAGCACCCGAGCCCCCCGCCCCCATGATGAA CCGGGCGAGCTCCTCCTT CAGGTGCGGCAGGAGCCCCACGTTCTCGACGCTGTAATACAGCGCGGTGTTGGGGGGCTG GGCGAAGCTGTGGGTGGA GTGATCAAAGAGGGGCCCGTTGACGAGCTCGAAGAAGCGATGGGTGATGCTGGGGAGCAG GGCCGGGTCCACCTGGTG TCGCAGGAGAGACGCTCGCATGAACCGGTGCGCGTCGAACACGCCCGGCGCCGAGCGGTT GTCGATGACCGTGCCCGC GCCCGCCGTCAGGGCGCAGAAGCGCGCGCGCGCCGCAAAGCCGTTGGCGACCGCGGCGAA CGTCGCGGGCAGCACCTC GCCGTGGACGCTGACCCGCAGCATCTTCTCGAGCTCCCCGCGCTGCTCGCGGACGCAGCG CCCCAGGCTGGCCAACGA CCGCTTCGTCAGGCGGTCCGCGTACAGCCGCCGTCGCTCCCGCACGTCCGCGGCCGCTTG CGTGGCGATGTCCCCCCA CGTCTCGGGCCCCTGCCCCCCGGGCCCGCGGCGACGGTCTTCGTCCTCGCCCCCGCCCCC GGGAGCTCCCAACCCCCG TGCCCCTTCCTCTACGGCGACACGGTCCCCGTCGTCGTCGGGGCCCGCGCCGCCCTTGGG CGCGTCCGCCGCGCCCCC CGCCCCCATGCGCGCCAGCACGCGACGCAGCGCCTCCTCGTCGCACTGTTCGGGGCTGAC GAGGCGCCGCAAGAGCGG CGTCGTCAGGTGGTGGTCGTAGCACGCGCGGATGAGCGCCTCGATCTGATCGTCGGGTGA CGTGGCCTGACCGCCGAT TATTAGGGCGTCCACCATATCCAGCGCCGCCAGGTGGCTCCCGAACGCGCGATCGAAATG CTCCGCCCGCCGCCCGAA CAGCGCCAGTTCCACGGCCACCGCGGCGGTCTCCTGCTGCAACTCGCGCCGCGCCAGCGC GGTCAGGTTGCTGGCAAA CGCGTCCATGGTGGTCTGGCCGGCGCGGTCGCCGGACGCGAGCCAGAATCGCAATTCGCT GATGGCGTACAGGCCGGG CGTGGTGGCCTGAAACACGTCGTGCGCCTCCAGCAGGGCGTCGGCCTCCTTGCGGACCGA GTCGTTCTCGGGCGACGG GTGGGGCTGCCCGTCGCCCCCCGCGGTCCGGGCCAGCGCATGGTCCAACACGGAGAGCGC CCGCGCGCGGTCGGCGTC CGACAGCCCGGCGGCGTGGGGCAGGTACCGCCGCAGCTCGTTGGCGTCCAGCCGCACCTG CGCCTGCTGGGTGACGTG GTTACAGATACGGTCCGCCAGGCGGCGGGCGATCGTCGCCCCCTGGTTCGCCGTCACACA CAGTTCCTCGAAACAGAC CGCGCAGGGGTGGGACGGGTCGCTAAGCTCCGGGGGGACGATAAGGCCCGACCCCACCGC CCCCACCATAAACTCCCG AACGCGCTCCAGCGCGGCGGTGGCGCCGCGCGAGGGGGTGATGAGGTGGCAGTAGTTTAG CTGCTTTAGAAAGTTCTC GACGTCGTGCAGGAAACACAGCTCCATATGGACGGTCCCGCCATACGTATCCAGCCTGAC CCGTTGGTGATACGGACA GGGTCGGGCCAGGCCCATGGTCTCCGTGAAAAACACCGCGACGTCTCCCGCGGTCGCGAA CGTCTCCAGGCTGCCCAG GAGCCGCTCGCCCTCGCGCCACGCGTACTCTAGCAGCAACTCCAGGGTGACCGACAGCGG GGTGAGAAAGGCCCCGGC CTGGGCCTCCAGGCCCGGCCTCAGACGACGCCGCAGCGCCCGCACCTGAAGCGCGTTCAG CTTCAGTTGGGGGAGCTT CCCCCGTCCGATGTGGGGGTCGCACCGCCGGAGCAGCTCTATCTGAAACACATAGGTCTG CACCTGTCCGAGCAGGGC TAACAACTTTTGACGGGCCACGGTGGGCTCGGACACCGGGGCGGCCATCTCGCGGCGCCG ATCTGTACCGCGGCCGGA GTATGCGGTGGACCGAGGCGGTCCGTACGCTACCCGGCGTCTGGCTGAGCCCCGGGGTCC CCCTATTCGGGGCGGCCT CCCGCGGGCCCGCCGACCGGCAAGCCGGGAGTCGGCGGCGCGTGCGTTTCTGTTCTATTC CCAGACACCGCGGAGAGG AAT C AC GGCCCGCC C AGAGAT AT AGAC AC G GAAC AC AAAC AAG C AC G GAT GT C GT AG C AAT AAT T TAT T T T AC AC AC A TTCCCCGCCCCGCCCTAGGTTCCCCCACCCCCCAACCCCTCACAGCATATCCAACGTCAG GTCTCCCTTTTTGTCGGG GGGCCCCTCCCCAAACGGGTCATCCCCGTGGAACGCCCGTTTGCGGCCGGCAAATGCCGG TCCCGGGGCCCCCGGGCC GCCGAACGGCGTCGCGTTGTCGTCCTCGCAGCCAAAATCCCCAAAGTTAAACACCTCCCC GACGTTGCCGAGTTGGCT GACTAGGGCCTCGGCCTCGTGCGCCACCTCCAGGGCCGCGTCCGTCGACCACTCGCCGTT GCCGCGCTCCAGGGCACG TGCGGTCAGCTCCATCATCTCCTCGCTTAGGTACTCGTCCTCCAGGAGCGCCAGCCAGTC CTCGATCTGCAGCTGTTG GGTGCGGGGCCCCAGGCTTTTCACGGTCGCCACGAACACGCTACTGGCGACGGCCGCCCC GCCCTCGGAGATAATGCC CCGGAGCTGCTCGCACAGCGAGCTTTCGTGCGCTCCGCCGCCGAGGCTCGAGGCCGCGCA CACAAACCCGGCCCGGGG ACAGGCCAGGACGAACTTGCGGGTGCGGTCAAAAATAAGGAGCGGGCACGCGTTTTTGCC GCCCATCAGGCTGGCCCA GTTCCCGGCCTGAAACACACGGTCGTTGCCGGCCATGCCGTAGTATTTGCTGATGCTCAA CCCCAACACGACCATGGG GCGTGCCGCCATGACGGGCCGCAGCAGGTTGCAGCTGGCGAACATGGAGGTCCACGCGCC CGGATGCGCGTCCACGGC GTCCATCAGCGCGCGGGCCCCGGCCTCCAGGCCCGCCCCGCCCTGCGCGGACCACGCGGC CGCCGCCTGCACGCTGGG GGGACGGCGGGACCCCGCGATGATGGCCGTGAGGGTGTTGATGAAGTACGTCGAGTGATC GCAGTACCGCAGAATCTG GTTTGCCATGTAGTACATCGCCAGCTCGCTCACGTTGTTGGGGGCCAGGTTAATAAAGTT GATCGCGCCGTAGTCCAG GGAAAACTTTTTAATGAACGCGATGGTCTCGATGTCCTCGCGCGACAGGAGCCGGGCGGG AAGCTGGTTGCGTTGGAG GGCCGTCCAGAACCACTGCGGGTTCGGCTGGTTGGACCCCGGGGGCTTGCCGTTGGGGAA GATGGCCGCGTGGAACTG CTTCAGCAGAAAGCCCAGCGGTCCGAGGAGGATGTCCACGCGCTTGTCGGGCTTCTGGTA GGCGCTCTGGAGGCTGGC GACCCGCGCCTTGGCGGCCTCGGACGCGTTGGCGCTCGCGCCCGCGAACAACACGCGGCT CTTGACGCGCAGCTCCTT GGGAAACCCCAGGGTCACGCGGGCAACGTCGCCCTCGAAGCTGCTCTCGGCGGGGGCCGT CTGGCCGGCCGTCAGGCT GGGGGCGCAGATAGCCGCACCCTCCGAGAGCGCGACCGTCAGCGTTTTGGCCGACAGAAA CCCGTTGTTAAACATGTC CATCACGCGCCGCCGCAGCACCGGTTGGAATTGATTGCGAAAGTTGCGCCCCTCGACCGA CTGCCCGGCGAACACCCC GTGGCACTGGCTCAGGGCCAGGTCCTGGTACACGGCGAGGTTGGATCGCCGCCCGAGAAG CTGAAGCAGGGGGCACGG CCCGCACGCGTACGGGTCCAGCGTCAGGGACATGGCGTGGTTGGCCTCGCCCAGACCGTC GCGAAACTTGAAGTTCCT CCCCTCCACCAGGTTGCGCATCAGCTGCTCCACCTCGCGGTCCACGACCTGCCTGACGTT GTTCACCACCGTATGCAG GGCCTCGCGGTTGGTGATGATGGTCTCCAGCCGCCCCATGGCCGTGGGGACCGCCTGGTC CACGTACTGCAGGGTCTC GAGTTCGGCCATGACGCGCTCGGTCGCCGCGCGGTACGTCTCCTGCATGATGGTCCGGGC GGTCTCGGATCCGTCCGC GCGCTTCAGGGCCGAGAAGGCGGCGTAGTTTCCCAGCACGTCGCAGTCGCTGTACATGCT GTTCATGGTCCCGAAGAC GCCGATGGCTCCGCGGGCGGCGCTGGCGAACTTGGGATGGCGCGCCCGGAGGCGCATGAG CGTCGTGTGTACGCAGGC GTGGCGCGTGTCGAAGGTGCACAGGTTACAGGGCACGTCGGTCTGGTTGGAGTCCGCGAC GTATCGAAACACGTCCAT CTCCTGGCGCCCGACGATCACGCCGCCGTCGCAGCGCTCCAGGTAAAACAGCATCTTGGC CAGCAGCGCCGGGGAAAA CCCACACAACATGGCCAGGTGCTCGCCGGCAAATTCCTGGGTTCCGCCGACGAGGGGCGC GGTGGGCCGACCCTCGAA CCCGGGCACCACGTGTCCCTCGCGGTCCACCTGTGGGTTGGCCGCCACGTGGGTCCCGGG CACGAGGAAGAAGCGGTA AAAGGAGGGTTTGCTGTGGTCCTTTGGGTCCGCCGGGCCGGCGTCGTCCACCTCGGTGAG ATGGAGGGCCGAGTTGGT GCTAAATACCATGGCCCCCACGAGTCCCGCGGCGCGCGCCAGGTACGCCCCGACGGCGTT GGCGCGGGCCGCGGCCGT GTCCTGGCCCTCGAACAGCGGCCACGCGGAGATGTCGGTGGGCGGCTCGTCAAAGACGGC CATCGACACGATAGACTC GAGGGCCAGGGCGGCATCTCCGGCCATGACGGAGGCCAGGCGCTGTTCGAACCCGCCCGC AGGGCCCTTGCCGCCGCC GTCACGCCCGCCCCGCGGGGTCTTACCCTGGCTGGCTTCGAAGGCCGTGAACGTAATGTC GGCGGGGAGGGCGGCGCC CTCGTGGTTTTCGTCAAACGCCAGGTGGGCGGCCGCGCGGGCCACGGCGTCCACGTTTCG GCATCGCAGTGCCACGGC GGCGGGTCCCACGACCGCCTCGAACAGGAGGCGGTGGAGGGGGCGGTTAAAAAACGGAAG CGGGTAGGTAAAATTCTC CCCGATAGATCGGTGGTTGGCGTTGAACGGCTCTGCGATGACACGGCTAAAATCCGGCAT GAACAGCTGCAACGGGTA CACGGGTATGCGGTGCACCTCCGCCCCGCCTATGGTTACCTTGTCCGAGCCTCCCAGGTG CAGAAAGGTGTTGTTGAT GCACACGGCCTCCTTGAAGCCCTCGGTAACGACCAGATACAGGAGGGCGCGGTCCGGGTC CAGGCCGAGGCGCTCACA CAGCGCCTCCCCCGTCGTCTCGTGTTTGAGGTCGCCGGGCCGGGGGGTGTAGTCCGAAAA GCCAAAATGGCGGCGTGC CCGCTCGCAGAGTCGCGTCAGGTTCGGGGCCTGGGTGCTGGGGTCCAGGTGCCGGCCGCC GTGAAAGACGTACACGGA CGAGCTGTAGTGCGAGGGCGTCAGTTTCAGGGACACCGCGGTACCCCCGAGCCCCGTCGT GCGAGAACCCACGACCAC GGCCACGTTGGCCTCAAAGCCGCTCTCCACGGTCAGGCCCACGACCAGGGGCGCCACGGC GACGTCGGCATCGCCGCT GCGCGCCGACAGTAACGCCAGAAGCTCGATGCCTTCGGACGGACACGCGCGAGCGTACAC GTATCCCAGGGGCCCGGG GGGGACCTTGATGGTGGTTGCCGTCTTGGGCTTTGTCTCCATGTCCTTCTGTCAATCGGT CCGCGAACGGAGGTAATC CCGGCACGACGACGGACGCCCGACAAGGTATGTCTCCCGAGCGTCAAAATCCGGGGGGGG GCGGCGACGGTCAAGGGG AGGGTTGGAGACCGGGGTTGGGGAATGAATCCCTACCCTTCACCGACAACCCCCCGGGTA ATCACGGGGTGCCGATGA ACCCCGGCGGCCGGCAACGCGGGGTCCCTGCGAGAGGCACAGATGCTTACGGTCAGGTGC TCCGGGTCGGGTGCGTCT GGTATGCGGTTGGTATATGTACACTTTACCTGGGGGCGTGCCTGGCCGCCCCAGCCCCTC CCACGCCCCGCGCGTCAT CAGCCGGTGGGCGTGGCCGCTATTATAAAAAAAGTGAGAACGCGAAGCGTTCGCACTTTG TCCTAATAATATATATAT TATTAGGACAAAGTGCGAACGCTTCGCGTTCTCACTTTTTTTATAATAGCGCCCACGCCC ACCGGCTACGTCACGCTC CTGTCGGCCGCCGGCGGTCCATAAGCCCGGCCGGCCGGGCCGACGCGAATAAACCGGGCC GCCGGCCGGGGCGCCGCG CAGCAGCTCGCCGCCCGGATCCGCCAGACAAACAAGGCCCTTGCACATGCCGGCCCGGGC GAGCCTGGGGGTCCGGTA ATTTTGCCATCCCACCCAAGCGGCTTTTTGGGTTTTTCTCTTCCCCCCTCCCCACATCCC CCCTCTTTAGGGGTTCGG GTGGTAACAACCGCGATGTTTTCCGGTGGCGGCGGCCCGCTGTCCCCCGGAGGAAAGTCG GCGGCCAGGGCGGCGTCC GGGTTTTTTGCGCCCGCCGGCCCTCGCGGAGCCGGCCGGGGACCCCCGCCTTGCTTGAGG CAAAACTTTTACAACCCC TACCTCGCCCCAGTCGGGACGCAACAGAAGCCGACCGGGCCAACCCAGCGCCATACGTAC TATAGCGAATGCGATGAA TTTCGATTCATCGCCCCGCGGGTGCTGGACGAGGATGCCCCCCCGGAGAAGCGCGCCGGG GTGCACGACGGTCACCTC AAGCGCGCCCCCAAGGTGTACTGCGGGGGGGACGAGCGCGACGTCCTCCGCGTCGGGTCG GGCGGCTTCTGGCCGCGG CGCTCGCGCCTGTGGGGCGGCGTGGACCACGCCCCGGCGGGGTTCAACCCCACCGTCACC GTCTTTCACGTGTACGAC ATCCTGGAGAACGTGGAGCACGCGTACGCATGCGCGCGGCCCAGTTCCACGCGCGGTTTA TGGACGCCATCACACCGA CGGGGACCGTCATCACGCTCCTGGGCCTGACTCCGGAAGGCCACCGGGTGGCCGTTCACG TTTACGGCACGCGGCAGT ACTTTTACATGAACAAGGAGGAGGTCGACAGGCACCTACAATGCCGCGCCCCACGAGATC TCTGCGAGCGCATGGCCG CGGCCCTGCGCGAGTCCCCGGGCGCGTCGTTCCGCGGCATTTCCGCGGACCACTTCGAGG CGGAGGTGGTGGAGCGCA CCGACGTGTACTACTACGAGACGCGCCCCGCTCTGTTTTACCGCGTCTACGTCCGAAGCG GGCGCGTGCTGTCGTACC TGTGCGACAACTTCTGCCCGGCCATCAAGAAGTACGAGGGTGGGGTCGACGCCACCACCC GGTTCATCCTGGACAACC CCGGGTTCGTCACCTTCGGCTGGTACCGTCTCAAACCGGGCCGGAACAACACGCTAGCCC AGCCGGCGGCCCCGATGG CCTTCGGGACATCCAGCGACGTCGAGTTTAACTGTACGGCGGACAACCTGGCCATCGAGG GGGGCATGAGCGACCTAC CGGCATACAAGCTCATGTGCTTCGATATCGAATGCAAGGCGGGGGGGGAGGACGAGCTGG CCTTTCCGGTGGCCGGGC ACCCGGAGGACCTGGTCATCCAGATATCCTGTCTGCTCTACGACCTGTCCACCACCGCCC TGGAGCACGTCCTCCTGT TTTCGCTCGGTTCCTGCGACCTCCCCGAATCCCACCTGAACGAGCTGGCGGCCAGGGGCC TGCCCACGCCCGTGGTTC TGGAATTCGACAGCGAATTCGAGATGCTGTTGGCCTTCATGACCCTTGTGAAACAGTACG GCCCCGAGTTCGTGACCG GGTACAACATCATCAACTTCGACTGGCCCTTCTTGCTGGCCAAGCTGACGGACATTTACA AGGTCCCCCTGGACGGGT ACGGCCGCATGAACGGCCGGGGCGTGTTTCGCGTGTGGGACATAGGCCAGAGCCACTTCC AGAAGCGCAGCAAGATAA AGGTGAACGGCATGGTGAACATCGACATGTACGGGATTATAACCGACAAGATCAAGCTCT CGAGCTACAAGCTCAACG CCGTGGCCGAAGCCGTCCTGAAGGACAAGAAGAAGGACCTGAGCTATCGCGACATCCCCG CCTACTACGCCGCCGGGC CCACGCAACGCGGGGTGATCGGCGAGTACTGCATACAGGATTCCCTGCTGGTGGGCCAGC TGTTTTTTAAGTTTTTGC CCCATCTGGAGCTCTCGGCCGTCGCGCGCTTGGCGGGTATTAACATCACCCGCACCATCT ACGACGGCCAGCAGATCC GCGTCTTTACGTGCCTGCTGCGCCTGGCCGACCAGAAGGGCTTTATTCTGCCGGACACCC AGGGGCGATTTAGGGGCG CCGGGGGGGAGGCGCCCAAGCGTCCGGCCGCAGCCCGGGAGGACGAGGAGCGGCCAGAGG AGGAGGGGGAGGACGAGG ACGAACGCGAGGAGGGCGGGGGCGAGCGGGAGCCGGAGGGCGCGCGGGAGACCGCCGGCC GGCACGTGGGGTACCAGG GGGCCAGGGTCCTTGACCCCACTTCCGGGTTTCATGTGAACCCCGTGGTGGTGTTCGACT TTGCCAGCCTGTACCCCA GCATCATCCAGGCCCACAACCTGTGCTTCAGCACGCTCTCCCTGAGGGCCGACGCAGTGG CGCACCTGGAGGCGGGCA AGGACTACCTGGAGATCGAGGTGGGGGGGCGACGGCTGTTCTTCGTCAAGGCTCACGTGC GAGAGAGCCTCCTCAGCA TCCTCCTGCGGGACTGGCTCGCCATGCGAAAGCAGATCCGCTCGCGGATTCCCCAGAGCA GCCCCGAGGAGGCCGTGC TCCTGGACAAGCAACAGGCCGCCATCAAGGTCGTGTGTAACTCGGTTTACGGGTTCACGG GAGTGCAGCACGGACTCC TGCCGTGCCTGCACGTTGCCGCGACGGTGACGACCATCGGCCGCGAGATGCTGCTCGCGA CCCGCGAGTACGTCCACG CGCGCTGGGCGGCCTTCGAACAGCTCCTGGCCGATTTCCCGGAGGCGGCCGACATGCGCG CCCCCGGGCCCTATTCCA TGCGCATCATCTACGGGGACACGGACTCCATCTTTGTGCTGTGCCGCGGCCTCACGGCCG CCGGGCTGACGGCCGTGG GCGACAAGATGGCGAGCCACATCTCGCGCGCGCTGTTTCTGTCCCCCATCAAACTCGAGT GCGAAAAGACGTTCACCA AGCTGCTGCTGATCGCCAAGAAAAAGTACATCGGCGTCATCTACGGGGGTAAGATGCTCA TCAAGGGCGTGGATCTGG TGCGCAAAAACAACTGCGCGTTTATCAACCGCACCTCCAGGGCCCTGGTCGACCTGCTGT TTTACGACGATACCGTAT CCGGAGCGGCCGCCGCGTTAGCCGAGCGCCCCGCAGAGGAGTGGCTGGCGCGACCCCTGC CCGAGGGACTGCAGGCGT TCGGGGCCGTCCTCGTAGACGCCCATCGGCGCATCACCGACCCGGAGAGGGACATCCAGG ACTTTGTCCTCACCGCCG AACTGAGCAGACACCCGCGCGCGTACACCAACAAGCGCCTGGCCCACCTGACGGTGTATT ACAAGCTCATGGCCCGCC GCGCGCAGGTCCCGTCCATCAAGGACCGGATCCCGTACGTGATCGTGGCCCAGACCCGCG AGGTAGAGGAGACGGTCG CGCGGCTGGCCGCCCTCCGCGAGCTCGACGCCGCCGCCCCAGGGGACGAGCCCGCCCCCC CCGCGGCCCTGCCCTCCC CGGCCAAGCGCCCCCGGGAGACGCCGTTGCATGCCGACCCCCCGGGAGGCGCGTCCAAGC CCCGCAAGCTGCTGGTGT CCGAGCTGGCCGAGGATCCCGCATACGCCATTGCCCACGGCGTCGCCCTGAACACGGACT ATTACTTCTCCCACCTGT TGGGGGCGGCGTGCGTGACATTCAAGGCCCTGTTTGGGAATAACGCCAAGATCACCGAGA GTCTGTTAAAAAGGTTTA TTCCCGAAGTGTGGCACCCCCCGGACGACGTGGCCGCGCGGCTCCGGGCCGCAGGGTTCG GGGCGGTGGGTGCCGGCG CTACGGCGGAGGAAACTCGTCGAATGTTGCATAGAGCCTTTGATACTCTAGCATGAGCCC CCCGTCGAAGCTGATGTC CCTCATTTTACAATAAATGTCTGCGGCCGACACGGTCGGAATCTCCGCGTCCGTGGGTTT CTCTGCGTTGCGCCGGAC CACGAGCACAAACGTGCTCTGCCACACGTGGGCGACGAACCGGTACCCCGGGCACGCGGT GAGCATCCGGTCTATGAG CCGGTAGTGCAGGTGGGCGGACGTGCCGGGAAAGATGACGTACAGCATGTGGCCCCCGTA AGTGGGGTCCGGGTAAAA CAACAGCCGCGGGTCGCACGCCCCGCCTCCGCGCAGGATCGTGTGGACGAAAAAAAGCTC GGGTTGGCCAAGAATCCC GGCCAAGAGGTCCTGGAGGGGGGCGTTGTGGCGGTCGGCCAACACGACCAAGGAGGCCAG GAAGGCGCGATGCTCGAA TATCGTGTTGATCTGCTGCACGAAGGCCAGGATTAGGGCCTCGCGGCTGGTGGCGGCGAA CCGCCCGTCTCCCGCGTT GCACGCGGGACAGCAACCCCCGATGCCTAGGTAGTAGCCCATCCCGGAGAGGGTCAGGCA GTTGTCGGCCACGGTCTG GTCCAGACAGAAGGGCAGCGAGACGGGAGTGGTCTTCACCAGGGGCACCGAGAGCGAGCG CACGATGGCGATCTCCTC GGAGGGCGTCTGGGCGAGGGCGGCGAAAAGGCCCCGATAGCGCTGGCGCTCGTGTAAACA CAGCTCCTGTTTGCGGGC GTGAGGCGGCAGGCTCTTCCGGGAGGCCCGACGCACCACGCCCAGAGTCCCGCCGGCCGC AGAGGAGCGCGACCGCCG GCGCTCCTTGCCGTGATAGGGCCCGGGCCGGGAGCCGCGGCGATGGGGGTCGGTGTCATA CATAGGTACACAGGGTGT GCTCCAGGGACAGGAGCGAGATCGAGTGGCGTCTAAGCAGCGCGCCCGCCTCACGGACAA ATGTGGCGAGCGCGGTGG GCTTTGGTACAAATACCTGATACGTCTTGAAGGTGTAGATGAGGGCACGCAACGCTATGC AGACACGCCCCTCGAACT CGTTCCCGCAGGCCAGTTTGGCCTTGTGGAGCAGCAGCTCGTCGGGATGGGTGGCGGGGG GATGGCCGAACAGAACCC AGGGGTCAACCTCCATCTCCGTAATGGCGCACATGGGGTCACAGAACATGTGCTTAAAGA TGGCCTCGGGCCCCGCGG CCCGAAGCAGGCTCACAAACCGGCCCCCGTCCCCGGGCTGCGTCTCGGGGTCAGCCTCGA GCTGGTCGACGACGGGTA CGATACAGTCGAAGAGGCTCGTGTTGTTTTCCGAGTAGCGGACCACGGAGGCCCGGAGTC TGCGCAGGGCCAGCCAGT AAGCACGCACCAGTAACAGGTTACACAGCAGGCATTCTCCGCCGGTGCGCCCGCGCCCCC GGCCGTGTTTCAGCACGG TGGCCATCAGAGGGCCCAGGTCGAGGTCGGGCTGGGCATCGGGTTCGGTAAACTGCGCAA AGCGCGGAGCCACGTCGC GCGTGCGTGCCCCGCGATGCGCTTCCCAGGACTGGCGGACCGTGGCGCGACGGGCCTCCG CGGCAGCGCGCAGCTGGG GCCCCGACTCCCAGACGGCGGGGGTGCCGGCGAGGAGCAGCAGGACCAGATCCGCGTACG CCCACGTATCCGGCGACT CCTCCGGCTCGCGGTCCCCGGCGACCGTCTCGAATTCCCCGTTGCGAGCGGCGGCGCGCG TACAGCAGCTGTCCCCGC CCCCGCGCCGACCCTCCGTGCAGTCCAGGAGACGGGCGCAATCCTTCCAGTTCATCAGCG CGGTGGTGAGCGACGGCT GCGTGCCGGATCCCGCCGACCCCGCCCCCTCCTCGCCCCCGGAGGCCAAGGTTCCGATGA GGGCCCGGGTGGCAGACT GCGCCAGGAACGAGTAGTTGGAGTACTGCACCTTGGCGGCTCCCGGGGAGGGCGAGGGCT TGGGTTGCTTCTGGGCAT GCCGCCCGGGCACCCCGCCGTCGGTACGGAAGCAGCAGTGGAGAAAAAAGTGCCGGTGGA TGTCGTTTATGGTGAGGG CAAAGCGTGCGAAGGAGCCGACCAGGGTCGCCTTCTTGGTGCGCAGAAAGTGGCGGTCCA TGACGTACACAAACTCGA ACGCGGCCACGAAGATGCTAGCGGCGCAGTGGGGCGCCCCCAGGCATTTGGCACAGAGAA ACGCGTAATCGGCCACCC ACTGAGGCGAGAGGCGGTAGGTTTGCTTGTACAGCTCGATGGTGCGGCAGACCAGACAGG GCCGGTCCAGCGCGAAGG TGTCGATGGCCGCCGCGGAAAAGGGCCCGGTGTCCAAAAGCCCCTCCCCACAGGGATCCG GGGGCGGGTTGCGGGGTC CTCCGCGCCCGCCCGAACCCCCTCCGTCGCCCGCCCCCCCGCGGGCCCTTGAGGGGGCGG TGACCACGTCGGCGGCGA CGTCCTCGTCGAGCGTACCGACGGGCGGCACACCTATCACGTGACTGGCCGTCAGGAGCT CGGCGCAGAGAGCCTCGT TAAGAGCCAGGAGGCTGGGATCGAAGGCCACATACGCGCGCTCGAACGCCCCCGCCTTCC AGCTGCTGCCGGGGGACT CTTCGCACACCGCGACGCTCGCCAGGACCCCGGGGGGCGAAGTTGCCATGGCTGGGCGGG AGGGGCGCACGCGCCAGC GAACTTTACGGGACACAATCCCCGACTGCGCGCTGCGGTCCCAGACCCTGGAGAGTCTAG ACGCGCGCTACGTCTCGC GAGACGGCGCGCATGACGCGGCCGTCTGGTTCGAGGATATGACCCCCGCCGAGCTGGAGG TTGTCTTCCCGACTACGG ACGCCAAGCTGAACTACCTGTCGCGGACGCAGCGGCTGGCCTCCCTCCTGACGTACGCCG GGCCTATAAAAGCGCCCG ACGACGCCGCCGCCCCGCAGACCCCGGACACCGCGTGTGTGCACGGCGAGCTGCTCGCCC GCAAGCGGGAAAGATTCG CGGCGGTCATTAACCGGTTCCTGGACCTGCACCAGATTCTGCGGGGCTGACGCGCGTGCT GTTGGGCGGGACGGTTCG CGAACCCTTTGGTGGGTTTACGCGGGCACGCACGCTCCCATCGCGGGCGCCATGGCGGGA CTGGGCAAGCCCTACACC GGCCACCCAGGTGACGCCTTCGAGGGTCTCGTTCAGCGAATTCGGCTTATCGTCCCATCT ACGTTGCGGGGCGGGGAC GGGGAGGCGGGCCCCTACTCTCCCTCCAGCCTCCCCTCCAGGTGCGCCTTTCAGTTTCAT GGCCATGACGGGTCCGAC GAGTCGTTTCCCATCGAGTATGTACTGCGGCTTATGAACGACTGGGCCGAGGTCCCGTGC AACCCTTACCTGCGCATA CAGAACACCGGCGTGTCGGTGCTGTTTCAGGGGTTTTTTCATCGCCCACACAACGCCCCC GGGGGCGCGATTACGCCA GAGCGGACCAATGTGATCCTGGGGTCCACCGAGACGACGGGGTTGTCCCTCGGCGACCTG GACACCATCAAGGGGCGG CTCGGCCTGGATGCCCGGCCGATGATGGCCAGCATGTGGATCAGCTGCTTTGTGCGCATG CCCCGCGTGCAGCTCGCG TTTCGGTTCATGGGCCCCGAAGATGCCGGACGGACGAGACGGATCCTGTGCCGCGCCGCC GAGCAGGCTATTACCCGT CGCCGCCGAACCCGGCGGTCCCGGGAGGCGTACGGGGCCGAGGCCGGGCTGGGGGTGGCC GGAACGGGTTTCCGGGCC AGGGGGGACGGTTTTGGCCCGCTCCCCTTGTTAACCCAAGGGCCCTCCCGCCCGTGGCAC CAGGCCCTGCGGGGTCTT AAGCACCTACGGATTGGCCCCCCCGCGCTCGTTTTGGCGGCGGGACTCGTCCTGGGGGCC GCTATTTGGTGGGTGGTT GGTGCTGGCGCGCGCCTATAAAAAAGGACGCACCGCCGCCCTAATCGCCAGTGCGTTCCG GACGCCTTCGCCCCACAC AGCCCTCCCGACCGACACCCCCATATCGCTTCCCGACCTCCGGTCCCGATGGCGTCCCGC AATTTCACCGCCCCAACA CCGTTACCACCGATAGCGTCCGGGCGCTTGGCATGCGCGGGCTCGTCTTGGCCACCAATA ACTCTCAGTTTATCATGG ATAACAACCACCCACACCCCCAGGGCACCCAAGGGGCCGTGCGGGAGTTTCTCCGCGGTC AGGCGGCGGCACTGACGG ACCTTGGTCTGGCCCACGCAAACAACACGTTTACCCCGCAGCCTATGTTCGCGGGCGACG CACCGGCCGCCTGGTTGC GGCCCGCGTTTGGCCTGCGGCGCACCTATTCACCTTTTGTCGTTCGAGAACCTTCGACGC CCGGGACCCCGTGAGGCC CAGGGAGTTCCTTCTGGGGTGTTTTAATCAATAAAAGACCACACCAACGCACGAGCCTTG CGTTTAATGTCGTGTTTA TTCAAGGGAGTGGGATAGGGTTCGACGGTTCGAAACTTAACACACCAAATAATCGAGCGC GTCTAGCCCAGTAACATG CGCACGTGATGTAGGCTGGTCAGCACGGCGTCGCTGTGATGAAGCAGCGCCCGGCGGGTC CGCTGTAACTGCTGTTGT AGGCGGTAACAGGCGCGGATCAGCACCGCCAGGGCGCTACGACCGGTGCGTTGCACGTAG CGTCGCGACAGAACTGCG TTTGCCGATACGGGCGGGGGGCCGAATTGTAAGCGCGTCACCTCTTGGGAGTCATCGGCG GATAACGCACTGAATGGT TCGTTGGTTATGGGGGAGTGTGGTTCCCCAGGGAGTGGGTCGAACGCCTCGGCCTCGGAA TCCGAGAGGAACAACGAG GTGGCGTCGGAGTCTTCGTCGTCAGAGACATACAGGGTCTGAAGCAGCGACACGGGCGGG GGGGTAGCGTCGATGTGT AGCGCGAGGGAGGATGCCCACGAAGACACCCCAGACAAGGAGCTGCCCGTGCGTGGATTT GTGGAAGACGCGGAAGCC GGGACGGATGGGCGGTTTTGCGGTGCCCGGAACCGAACCGCCGGATACTCCCCGGGTGCT ACATGCCCGTTTTGGGGC TGGGGTTGGGGCTGGGGTTGGGGCTGGGGTTGGGGCTGGGGTTGGGGCTGGGGTTGGGGC TGGGGTTGGGGTTGGGGT TGGGGCTGGGGTTGGGGTTGGGGCTGGGGCTGGGGCTGGGGCTGGGGCTGGGGCTGGGGC TGGGGCTGGGGCTGGGGC TGGGGCTGGGGCTGGGGCTGGGGCTGGGGCTGGGGTTGGGGCTGGGGCGCGGACAGGCGG CTGACGGTCAAATGCCCC CGGGGGCGCGCAGATGTGGTGGGCGTGGCCACCGGCTGCCGTGTAGTGGGGCGGCGGGAA ACCGGGCCTCCGGGCGTA ACACCGCCCTCCAGCGTCAAGTATGTGGGGGGCGGGCCTGACGTCGGGGGCGGGGTGACG GGTTGGACCGCGGGAGGC GGGGGAGAGGGACCTGCGGGAGAGGATGAGGTCGGCTCGGCCGGGTTGCGGCCTAAAACA GGGGCCGTGGGGTCGGCG GGGTCCCAGGGTGAAGGGAGGGATTCCCGCGATTCGGACAGCGACGCGACAGCGGGGCGC GTAAGGCGCCGCTGCGGC CCGCCTACGGGAACCCTGGGGGGGGTTGGCGCGGGACCCGAGGTTAGCGGGGGGCGGCGG TTTTCGCCCCCGGGCAAA ACCGTGCCGGTTGCGACCGGGGGCGGAACGGGATCGATAGGGAGAGCGGGAGAAGCCTGG CCGGCGGACTGGGGACCG AGCGGGAGGGGCACACCAGACACCAAAGCGTGGGGCGCTGGCTCTGGGGGTTTGGGAGGG GCCGGGGGGCGCGCGAAA TCGGTAACCGGGGCGACCGTGTCGGGGAGGGCAGGCGGCCGCCAACCCTGGGTGGTCGCG GAAGCCTGGGTGGCGCGC GCCAGGGAGCGTGCCCGGCGGTGTCGGCGCGCGCGCGACCCGGACGAAGAAGCGGTAGAA GCGCGGGAGGAGGCGGGG GGGCGGGGGGCGGTGGCATCGGGGGGCGCCGGGGAACTTTGGGGGGACGGCAAGCGCCGG AAGTCGTCGCGGGGGCCC ACGGGCGCCGGCCGCGTGCTTTCGGCCGGGACGCCCGGTCGTGCTTCGCGAGCCGTGACT GCCGGCCCAGGGGGCCGC GGTGCACACTGGGACGTGGGGACGGACTGATCGGCGGTGGGCGAAAGGGGGTCCGGGGCA AGGAGGGGCGCGGGGCCG CCGGAGTCGTCAGACGCGAGCTCCTCCAGGCCGTGAATCCATGCCCACATGCGAGGGGGG ACGGGCTCGCCGGGGGTG GCGTCGGTGAATAGCGTGGGGGCCAGGCTTCCGGGCCCCAACGAGCCCTCCGCCCCAACA AGGTCCGCCGGGCCGGGG GTCGGGTTCGGGACCGAGGGGCTCTGGTCGTCGGGGGCGCGCTGGTACACCGGATGCCCC GGGAATAGCTCCCCCGAC AGGAGGGAGGCGTCGAACGGCCGCCCGAGGATAGCTCGCGCGAGGAAGGGGTCCTCGTCG GTGGCGCTCGCGGCGAGG ACGTCCTCGCCGCCCACCACAAACGGGAGCTCCTCGGTGGCCTCGCTGCCAACAAACCGC ACGTCGGGGGGGCCGGGG GGGTCCGGGTTTTCCCACAACACCGCGACCGGGGTCATGGAGATGTCCACGAGCACCAGG CACGGCGGGCCCCGGGCG AGGGGCCGCTCGGCGATGAGCGCGGACAGGCGCGGGAGCTGTGCCGCCAGACACGCGTTT TCGATCGGGTTAAGGTCG GCGTGCAGGAGGCGGACGGCCCACGTCTCGATGTCGGACGACACGGCATCGCGCAAGGCG GCGTCCGGCCCGCGAGCG CGTGAGTCAAACAGCGTGAGGCACAGCTCCAGTTCCGACTCGCGGGAAAAGGCCGTGGTG TTGCGGAGCGCCACGACG ACGGGCGCGCCCAGGAGCACTGCCGCCAGCACCAGGTCCATGGCCGTAACGCGCGCCGCG GGGGTGCGGTGGGTGGCG GCGGCCGGCACGGCGACGTGCTGGCCCGTGGGCCGGTAGAGGGCGTTGGGGGGAGCGGGG GGTGACGCCTCGCGCCCC CCCGAGGGGCTCAGCGTCTGCCCAGATTCCAGACGCGCGGTCAGAAGGGCGTCGAAACTG TCATACTCTGTGTAGTCG TCCGGAAACATGCAGGTCCAAAGAGCGGCCAGCGCGGTGCTTGGGAGACACATGCGCCCG AGGACGCTCACCGCCGCC AGCGCCTGGGCGGGACTCAGCTTTCCCAGCGCGGCGCCGCGCTCGGTTCCCAGCTCGGGG ACCGAGCGCCAGGGCGCC AGGGGGTCGGTTTCGGACAACTTGCCGCGGCGCCAGTCTGCCAGCCGCGTGCCGAACATG AGGCCCCGGGTCGGAGGG CCTCCGGCCGAAAACGCTGGCAGCACGCGGATGCGGGCGTCTGGATGCGGGGTCAGGCGC TGCACGAATAGCATGGAA TCTGCTGCGTTCTGAAACGCACGGGGGAGGGTGAGATGCATGTACTCGTGTTGGCGGACC AGATCCAGGCGCCAAAAG GTGTAAATGTGTTCCGGGGAGCTGGCCACCAGCGCCACCAGCACGTCGTTCTCGTTAAAG GAAACGCGGTGCCTAGTG GAGCTCTGGGGTCCGAGCGGCGGCCCCGGGGCCGCCGCGTCACCCCCCCATTCCAGCTGG GCCCAGCGACACCCAAAC TCGCGCGTGAGAGTGGTCGCGACGAGGGCGACGTAGAGCTCGGCCGCCGCATCCATCGAG GCCCCCCATCTCGCCTGG CGGTGGCGCACAAAGCGTCCGAAGAGCTGAAAGTTGGCGGCCTGGGCGTCGCTGAGGGCC AGCTGAAACCGGTTGATG ACGGTGAGGACGTACATGGCCGTGACGGTCGAGGCCGACTCCAGGGTGTCCGTCGGAAGC GGGGGGCGAATGCATGCC GCCTCGGGACACATCAGCAGCGCGCCGAGCTTGTCGGTCACGGCCGGGAAGCAGAGCGCG TACTGCAGTGGCGTTCCA TCCGGGACCAAAAAGCTGGGGGCGAACGGCCTATCCAGCGTACTGGTGGCCTCGCGCAGC ACCAGGGGCCCCGGGCCT CCGCTCACTCGCAGGTACGCCTCGCCCCGGCGGCGCAGCATCTGCGGGTCGGCCTCTTGG CCGGGTGGGGCGGACGCC CGGGCGCGGGCGTCTAGGGCGCGAAGATCCACGAGCAGGGGCGCGGGCGCGGCCGCCGCG CCCGCGCCCGTCTGGCCT GTGGCCTTGGCGTACGCGCTATATAAGCCCATGCGGCGTTGGATGAGCTCCCGCGCGCCC CGGAACTCCTCCACCGCC CATGGGGCCAGGTCCCCGGCCACCGCGTCCAATTCCGCCAACAGGCCCCCCAGGGTGTCA AAGTTCATCTCCCAGGCC ACCCTTGGCACCACCTCGTCCCGCAGCCGGGCGCTCAGGTCGGCGTGTTGGGCCACGCGC CCCCCGAGCTCCTCCACG GCCCCGGCCCGCTCGGCGCTCTTGGCGCCCAGGACGCCCTGGTACTTGGCGGGAAGGCGC TCGTAGTCCCGCTGGGCT CGCAGCCCCGACACAGTGTTGGTGGTGTCCTGCAGGGCGCGAAGCTGCTCGCATGCCGCG CGAAATCCCTCGGGCGAT TTCCAGGCCCCCCCGCGAACGCGGCCGAAGCGACCCCATACCTCGTCCCACTCCGCCTCG GCCTCCTCGAAAGACCTC CGCAGGGCCTCGACGCGGCGACGGGTGTCGAAGAGCGACTGCAGGCGCGCGCCCTGTCGC GTCAGGAGGCCCGGGCCG TCGCCGCTGGCCGCGCTTAGCGGGTGCGTCTCAAAGGTGCGCTGGGCATGTTCCAACCAG GCGACCGCCTGCACGTCG AGCTCGCGCGCCTTCTCCGTCTGGTCCAACAGAATCTCGACCTGATCCGCGATCTCCTCC GCCGAGCGCGCCTGGTCC AGCGTCTTGGCCACGGTCGCCGGGACGGCAACCACCTTCAGCAGGGTCTTCAGATTGGCC AGACCCTCGGCCTCGAGC TGGGCCCGGCGCTCGCGCGCGGCCAGCACCTCCCGCAACCCCGCCGTGACCCGCTCGGTG GCTTCGGCGCGCTGCTGT TTGGCGCGCACCACGGCGTCCTTGGTATCGGCCAGGTCCTGTCGGGTCACGAATGCGACG TAGTCGGCGTACGCCGTG TCCTTCACGGGGCTCTGGTCCACGCGCTCCAGCGCCGCCACACACGCCACCAGCGCGTCC TCGCTCGGGCAGGGCAGG GTGACCCCTGCCCGGACAAGCTCGGCGGCCGCCGCCGGGTCGTTGCGCACCGCGGATATC TCCTCCGCGGCGGCGGCC AGGTCCAGCGCCACGCTTCCGATCGCGCGCCGCGCGTCGGCCCGGAGGGCGTCCAGGCGA TCGCGGATATCCACGTAC TCGGCGTAGCCCTTTTGAAAAAACGGCACGTACTGGCGCAGGGCCGGCACGCCCCCCAAG TCTTCCGACAGGTGTAGG ACGGCCTCGTGGTAGTCGATAAACCCGTCGTTCACCTGGGCCCGCTCCAGCAGCCCCCCC GCGAGCCGCAGAAGCCGC GCCAGGGGCTCGGTGTCCACCCGAAACATGTCGGCGTACGTGTCGGCCGCGGCCCCGAAG GCCGCGCTCCAGTCGATG CGGTGAATGGCTGCGAGCGGGGGGAGCATGGGGTGGCGCTGGTTCTCGGGGGTGTATGGG TTAAACGCAAGGGCCGTC TCCAGGGCAAGGGTCACCGCCTTGGCGTTGGTTCCCAGCGCCTGCTCGGCCCGCTTTCGG AAGTCCCGGGGGTTGTAG CCGTGCGTGCCCGCCAGCGCCTGCAGGCGACGGAGCTCGACCACGTCAAACTCGGCACCG CTTTCCACGCGGTCCAGC ACGGCCTCCACGTCGGCGGCCCAGCGCTCGTGGCTACTGCGGGCGCGCTGGGCCGCCATC TTCTCTCTGAGGTCGGCG GTGGCGGCCTCAAGTTCGTCGGCGCGGCGTCGCGTGGCGCCGATGACCTTTCCCAGCTCC TGCAGGGCGCGCCCGCTG GGGGAGTGGTCCCCGGCCGTCCCTTCGGCGTGCAACAGGCCCCCGAACCTGCCCTCGTGG CCCGCGAGGCTTTCCCGC GCGCCGGTGGTCGCGCGCGTCGCGGCCTGGATCAGGGAGGCATGCTCTCCCTCCGGTTGG TTGGCGGCCCGGCGCACC TGGACGACAAGGTCGGCGGCAGCCGACCCTAAGGTCGTGAGCTGGGCGATGGCCCCCCGC GCGTCCAGGGCCAACCGA GTCGCCTTGACGTATCCCGCGGCGCTGTCGGCCATGGCCGCTAGGAAGGCCAGGGGGGAG GCCGGGTCGCTGGCGGCC GCGCCCAGGGCCGTCACTGCGTCGACCAGGACGCGGTGCGCCCGCACGGCCGCATCCACC GTCGACGCGGGGTCTGCC GTCGCGACGGCGGCGCTGCCGGCGTTGATGGCGTTCGAGACGGCGTGGGCTATGATCGGG GCGTGATCGGCGAAGAAC TGCAAGAGAAACGGAGTCTCGGGGGCGTTGGCGAACAGGTTCTTCAGCACCACCACGAAG CTGGGATGCAAGCCGGAC AGAGCCGTCGCCGTGTCCGGAGTCGGGTGCTCCAGGGCATCTCGGTACTGCCCCAGCAGC CCCCACATGTCCGCCCGC AGCGCCGCCGTAACCTCCGGGGGCGCCCCCCGAACGGCCTCGGGGAGGTCCGACCAGCCC GCCGGCAGGGAGGCCCGC AGGGTCGTCAGGACGGCCGGACAGGCCTTTAGCCCCACAAAGTCAGGGAGGGGCCGCAGG ACCCCCTGGAGTTTGTGC AAGAACTTCTCCCGGGCGTCGCGGGCCACCTTCGCCCGCTCCCGCGCTCCCTCGAGCATT GCCTCCAGGGAGCGCGCG CGCTCCCGCAAACGGGCACGCGCATCGGGGGCGAGCTCTGCCGTCAGCTTGGCGGCATCC ATGGCCCGCGCCTGCCGC AGCGCTTCCTCGGCCATGCGCGTGGCCTCTGGCGACAGCCCGCCGTCGTCGGGGTAGGGC GACGCGCCGGGCGCAGGA ACAAAGGCCGCGTCGCTGTCCAGCTGCTGGCCCAGGGCCGCATCTAGGGCGTCGAAGCGC CGCAGCTCGGCCAGACCC GAGCTGCGGCGCGCCTGCTGGTCGTTAATGTCGCGGATGCTGCGCGCCAGCTCGTCCAGC GGCTTGCGTTCTATCAGC CCTTGGTTGGCGGCGTCCGTCAGGACGGAGAGCCAGGCCGCCAGGTCCTCGGGGGCGTCC AGCGTCTGGCCCCGCTGT ATCAGATCCCGCAACAGGATGGCCGTGGGGCTGGTCGCGATCGGGGGCGGGGCGGGAATG GCGGCGCTCTGCGCGATG TCCCGCGTGTGCTGGTCGAAGACAGGCAGGGACTCTAGCAGCTGGACCACGGGCACGACG GCGGCCGAAGCCACGTGA AACCGGCGGTCGTTGTTGTCGCTGGCCTGCAGAGCCTTGGCGCTGTATACGGCCCCCCGG TAAAAGTACTCCTTAACC GCGCCCTCGATCGCCCGACGGGCCTGGGTCCGCACCTCCTCCAGCCGAACCTGAACGGCC TCGGGGCCCAGGGGGGGT GGGCGCGGAGCCCCCTGCGGGGCCGCCCCGGCCGGGGCGGGCATTACGCCGAGGGGCCCG GCGTGCTGTGAGACCGCG TCGACCCCGCGAGCGAGGGCGTCGAGGGCCTCGCGCATCTGGCGATCCTCCGCCTCCACC CTAATCTCTTCGCCACGG GCAAATTTGGCCAGAGCCTGGACTCTATACAGAAGCGGTTCTGGGTGCGTCGGGGTGGCG GGGGCAAAAAGGGTGTCC GGGTGGGCCTGCGAGCGCTCCAGAAGCCACTCGCCGAGGCGTGTATACAGATTGGCCGGC GGGGCCGCGCGAAGCTGC AGCTCCAGGTCCGCGAGTTCCCCGTAAAAGGCGTCCGTCTCCCGAATGACATCCCTAGCC ACAAGGATCAGCTTCGCC AGCGCCAGGCGACCGATCAGAGAGTTTTCGTCCAGCACGTGCTGGACGAGGGGCAGATGG GCGGCCACGTCGGCCAGG CTCAGGCGCGTGGAGGCCAGAAAGTCCCCCACGGCCGTTTTCCGGGGCAGCATGCTCAGG GTAAACTCCAGCAGGGCG GCGGCCGGGCCGGCCACCCCGGCCTGGGTGTGCGTCCGGGCCCCGTTCTCGATGAGAAAG GCGAGGACGCGTTCAAAG AAAAAAATAACACAGAGCTCCAGCAGCCCCGGAGAAGCCGGATACGGCGACCGTAAGGCG CTGATGGTGAGCCGCGAA CACGCGGCGACCTCGCGGGCCAGGGCGGCGGAGCACGCGGTGAACTTAACCGCCGTGGCG GCCACGTTTGGGTGGGCC TCGAACAGCTGGGCAAGGTCTGCGCCCGGGGGCTCGGGTGAGCGGCGAGTCTTCAGCGCC TCGAGGGCCTGCGAGGAC GCCGGAACCGTGGGCCCGTCGTCCTCGCCCGCCTCGGCGACCGGCGGCCCGGCCGGGTCG GGGGGTGCCGAGGCGAGG ACAGGCTCCGGAACGGAGGCGGGGACCGCGGCCCCGACGGGGGTTTTGCCTTTGGGGGTG GATTTCTTCTTGGTTTTG GCAGGGGGGGCCGAGCGTTTCGTTTTCTCCCCCGAAGTCAGGTCTTCGACGCTGGAAGGC GGAGTCCAGGTGGGTCGG CGGCGCTTGGGAAGGCCGGCCGAGTAGCGTGCCCGGTGCCGACCAACCGGGACGACGCCC ATCTCCAGGACCCGCATG TCGTCGTCATCTTCTTCGGCCGCCTCTGCGGCGGGGGGCTTGGGGGCGGAGGGAGGCGGT GGTGGGATCGCGGAGGGT GGGTCGGCGGAGGGTGGGTCGGCGGAGGGGGGATCCGTGGGTGGGGTACCCTTCAGGGCC ACCGCCCATACATCGTCG GGCGCCCGATTCGGGCGCTTGGCCTCTGGTTTTGCCGACGGACCGGCCGTCCCCCGGGAT GTCTCGGAGGCCCTGTCG TCGCGACGGGCCCGGGTCGGTGGCGGCGACTGGGCGGCTGTGGGCGGGTGGGGCCCCGTG CCCCCTACCCCCTCCCGG GGGCCCACGCCGACGCAGGGCTCCCCCAGGCCCGCGATCTCGCCCCGCAGGGGGTGCGTG ATGGCCACGCGCCGTTCG CTGAACGCTTCGTCCTGCAGGTAAGTCTCGCTGGCCCCGTAAAGATGCAGAGCCGCGGCC GTCAAGTCCGCAGGAGCC GCGGGTTCCGGGCCCGACGGCACGAAAAACACCATGGCTCCCGCCCACCGTACGTCCGGG CGATCGCGGGTGTAATAC GTCAGGTATGGATACATGTCCCCCGCCCGCACTTTGGCGATGAACGCGGGGGTGCCCTCC GGAAGGCCGTGCGGGTCA AAAAGGTATGCGGTGTCGCCGTCCCTGAACAACCCCATCCCTAGGGGGCCAATGGTTAGG AGCGTGTACGACAGGGGG CGCAGGGCCCACGGGCCGGCGAAGAACGTGTGTGCGGGGCATTGTGTCTCCAGCAGGCCC GCCGCGGGCTCCCCGAAG AAGCCCACCTCGCCGTATACGCGCGAGAAGACACAGCGCAGTCCGCCGCGCGCCCCTGGG TACTCGAGGAAGTTGGGG AGCTCGACGATCGAACACATGCGCGGCGGCCCAGGGCCCGCGGTCGCGCGCGTCCACTCG CCCCCCTCGACCAAACAA CCCTCGATGGCCTCCGCGGACAGAACGTCGCGAGGGCCCACATCAAATATGAGGCTGAGA AAGGACAGCGACGAGCGC ATGCACGATACCGACCCCCCCGGCTCCAGGTCGGGCGCGAACTGGTTCCGAGCACCGGTG ACCACGATGTCGCGATCC CCCCCGCGTTCCATCGTGGAGTGCGGTGGGGTGCCCGCGATCATATGTGCCCTACTGGCC AGAGACCCGGCCTGTTTA TGGACCGGACCCCCGGGGTTAGTGTTGTTTCCGCCACCCATGCCCCCGTACCATGGCCCC GGTTCCCCTGATTAGGCT ACGAGTCGCGGTGATCGCTTCCCAAAAACCGAGCTGCGTTTGTCTGTCTTGATCTTTCCC CCCCCCCCCGCCCGCCCG CACACCATAACACCGAGAACAACACACGGGGGTGGGCGTAACATAATAAAGCTTTATTGG TAACTAGTTAACGGCAAG TCCGTGGGTGGCGCGACGGTGTCCTCCGGGCTCATCTCGTCGTCCTCGACGGGGGTGTTG GAATGAGGCGCCCCCTCG CGGTCCGCCTGGCGTGGGCCGTGCCCATAGGCCTCCGGCTTCTGTGCGTCCATGGGCATA GGCGCGGGGAGACTGTTT CCGGCGTCGCGGACCTCCAGGTCCCTGGGAGACTCCGGTCCGGCTAACGGACGAAACGCG GAAGCGCGAAACACGCCG TCGGTGACCCGCAGGAGCTCGTTCATCAGTAACCAATCCATACTCAGCGTAACGGCCAGC CCCTGGCGAGACAGATCC ACGGAATCCGGAACCGCGGTCGTCTGGCCCAGGGGGCCGAGGCTGTAGTCCCCCCAGGCC CCTAGGTCGCGACGGCTC GTAAGCACGACGCGGTCGGCCGCGGGGCTTTGCGGGGGGGCGTCCTCGGGCGCATGCGCC ATTACCTCTCGGATGGCC GCGGCGCGCTGGTCGGCCGAGCTGACCAAGGGCGCCACGACCACGGCGCGCTCCGTCTGC AGGCCCTTCCACGTGTCG TGGAGTTCCTGGACAAACTCGGCCACGGGCTCGGGTCCCGCGGCCGCGCGCGCGGCTTGA TAGCAGGCCGAGAGACGC CGCCAGCGCGCTAGAAACTGACCCATGAAGCAAAACCCGGGGACCTGGTCTCCCGACAGC AGCTTCGACGCCCGGGCG TGAATGCCGGACACGACGGACAGAAACCCGTGAATTTCGCGCCGGACCACGGCCAGCACG TTGTCCTCGTGCGACACC TGGGCCGCCAGCTCGTCGCACACCCCCAGGTGCGCCGTGGTTTCGGTGATGACGGAACGC AGGCTCGCGAGGGACGCG ACCAGCGCGCGCTTGGCGTCGTGATACATGCTGCAGTACTGACTCACCGCGTCCCCCATG GCCTCGGGGGGCCAGGGC CCCAGGCGGTCGGGCGTGTCCCCGACCACCGCATACAGGCGGCGCCCGTCGCTCTCGAAC CGACACTCGAAAAAGGCG GAGAGCGTGCGCATGTGCAGCCGCAGCAGCACGATGGCGTCCTCCAGTTGGCGAATCAGG GGGTCTGCGCGCTCGGCG AGGTCCTGCAGCACCCCCCGGGCGGCCAGGGCGTACATGCTAATCAACAGGAGGCTGGTG CCCACCTCGGGGGGCGGG GGGGGCTGCAGCTGGACCAGGGGCCGCAGCTGCTCGACGGCACCCCTGGAGATCACGTAC AGCTCCCGGAGCAGCTGC TCTATGTTGTCGGCCATCTGCATAGTGGGGCCGAGGCCGCCCCGGGCGGCCGGTTCGAGG AGGGTAATCAGCGCGCCC AGTTTGGTGCGATGGCCCTCGACCGTGGGGAGATAGCCCAGCCCAAAGTCCCGGGCCCAG GCCAACACACGCAGGGCG AACTCGACCGGGCGTGGAAGGTAGGCCGCGCTACACGTGGCCCTCAACGCGTCCCCGACC ACCAGGGCCAGAACGTAG GGGACGAAGCCCGGGTCGGCGAGGACGTTGGGGTGAATGCCCTCGAGGGCGGGGAAGCGG ATCTGGGTCGCCGCGGCC AGGTGGACAGAGGGGGCGTGGCTGGGCTGCCCGACGGGGAGAAGCGCGGACAGCGGCGTG GCCGGGGTGGTGGGGGTG ATGTCCCAGTGGGTCTGACCATACACGTCGATCCAGATGAGCGCCGTCTCGCGGAGAAGG CTGGGTTGACCGGAACTA AAGCGGCGCTCGGCCGTCTCAAACTCCCCCACGAGCGCCCGCCGCAGGCTCGCCAGATGT TCCGTCGGCACGGCCGGA CCCATGATACGCGCCAGCGTCTGGCTCAGAACGCCCCCCGACAGGCCGACCGCCTCGCAG AGCCGCCCGTGCGTGTGC TCGCTGGCGCCCTGGACCCGCCTGAAAGTTTTTACGTAGTTGGCATAGTACCCGTATTCC CGCGCCAGACCAAACACG TTCGACCCCGCGAGGGCAATGCACCCAAAGAGCTGCTGGACTTCGCCGAGTCCGTGGCCG GCGGGCGTCCGCGCGGGG ACGCCCGCCGCCAGAAACCCCTCCAGGGCCGAAAGGTAGTGCGTGCAGTGCGAGGGCGTG AACCCAGCGTCGATCAGG GTGTTGATCACCACGGAGGGCGAATTGGTATTCTGGATCAACGTCCACGTCTGCTGCAGC AGAGCCAACAGCCGCTGC TGGGCGCCGGCGGAGGGCTGCTCCCCGAGCTGCAGCAGGCTGGAGACGGCAGGCTGGAAG ACTGCCAGTGCCGACGAA CTCAGGAACGGCACGTCGGGATCAAACACGGCCACGTCCGTCCGCACGCGCGCCATTAGC GTCCCCGGGGGCGCACAG GCCGAGCGCGGGCTGACGCGGCTGAGGGCCGTCGACACGCGCACCTCCTCGCGGCTGCGA ACCATCTTGTTGGCCTCC AGTGGCGGAATCATTATGGCCGGGTCGATCTCCCGCACGGTGTGCTGAAACTGCGCCAAC AGGGGCGGCGGGACCACA GCCCCCCGCTCGGGGGTCGTCAGGTACTCGTCCACCAGGGCCAACGTAAAGAGGGCCCGT GTGAGGGGAGTGAGGGTC GCGTCGTCTATGCGCTGGAGGTGCGCCGAGAACAGCGTCACCCGATTACTCACCAGGGCC AAGAACCGGAGGCCCTCT TGCACGAACGGGGCGGGGAAGAGCAGGCTGTACGCCGGGGTGGTAAGGTTCGCGCTGGGC TGCCCCAACGGGACCGGC GCCATCTTGAGCGACGTCTCCCCAAGGGCCTCGATGGAGGTCCGCGGGCTCATGGCCAAG CAGCTCTTGGTGACGGTT TGCCAGCGGTCTATCCACTCCACGGCGCACTGGCGGACGCGGACCGGCCCCAGGGCCGCC GCGGTCGCAGGCCGGCGG AATCCAGCGCATGGGACGTGTCGGAGCCGGTGACCGCGAGGATGGTGTCCTTGATGACCT CCATCTCCCGGAAGGCCT GGTCGGGGGCCTCGGGGAGAGCCACCACCAAGCGGTGTACGAGCAACCCGGGGAGGTTCT CGGCCAAGAGCGCCGTCT CCGGAAGCCCGTGGGCCCGGTGGAACGCGCACAGGTGTTCCAGCAGCGGCCGCCAGCATG CCCGCGCGTCTGCCGGGG CGATGGCCGTTCCCGACAACAGAAACGCCGCCATGGCGGCGCGCAGCTTGGCCGTGGCCA GAAACGCCGGGTCGTCCG CCCCGTTTGCCGTCTCGGCCGTGGGGGTTGGCGGTTGGCGAAGGCCGGCTAGGCTCGCCA ATAGGCGCTGCATAGGTC CGTCCGAGGGCGGACCGGCGGGTGAGGTCGTGACGACGGGGGCCTCGGACGGGAGACCGC GGTCTGCCATGACGCCCG GCTCGCGTGGGTGGGGGACAGCGTAGACCAACGACGAGACCGGGCGGGAATGACTGTCGT GCGCTGTAGGGAGCGGCG AATTATCGATCCCCTGCGGCCCTCCAGGAACCCCGCAGGCGTTGCGAGTACCCCGCGTCT TCGCGGGGTGTTATACGG CCACTTAAGTCCCGGCATCCCGTTCGCGGACCCAGGCCCGGGGGATTGTCCGGATGTGCG GGCAGCCCGGACGGCGTG GGTTGCGGACTTTCTGCGGGGCGGCCCAAATGGCCCTTTAAACGTGTGTATACGGACGCG CCGGGCCAGTCGGCCAAC ACAACCCACCGGAGGCGGTAGCCGCGTTTGGCTGTGGGGTGGGTGGTTCCGCCTTGTGTG AGTGTCCTTTCGACCCCC CCCCCCCCCCTCCCCCGGGTCTTGCTAGGTCGCGATCTGTGGTCGCAATGAAGACCAATC CGCTACCCGCAACCCCTT CCGTGTGGGGCGGGAGTACCGTGGAACTCCCCCCCACCACACGCGATACCGCGGGGCAGG GCCTGCTTCGGCGCGTCC TGCGCCCCCCGATCTCTCGCCGCGACGGCCCAGTGCTCCCCAGGGGGTCGGGACCCCGGA GGGCGGCCAGCACGCTGT GGTTGCTTGGCCTGGACGGCACAGACGCGCCCCCTGGGGCGCTGACCCCCAACGACGATA CCGAACAGGCCCTGGACA AGATCCTGCGGGGCACCATGCGCGGGGGGGCGGCCCTGATCGGCTCCCCGCGCCATCATC TAACCCGCCAAGTGATCC TGACGGATCTGTGCCAACCCAACGCGGATCGTGCCGGGACGCTGCTTCTGGCGCTGCGGC ACCCCGCCGACCTGCCTC ACCTGGCCCACCAGCGCGCCCCGCCAGGCCGGCAGACCGAGCGGCTGGGCGAGGCCTGGG GCCAGCTGATGGAGGCGA CCGCCCTGGGGTCGGGGCGAGCCGAGAGCGGGTGCACGCGCGCGGGCCTCGTGTCGTTTA ACTTCCTGGTGGCGGCGT GTGCCGCCTCGTACGACGCGCGCGACGCCGCCGATGCGGTACGGGCCCACGTCACGGCCA ACTACCGCGGGACGCGGG TGGGGGCGCGCCTGGATCGTTTTTCCGAGTGTCTGCGCGCCATGGTTCACACGCACGTCT TCCCCCACGAGGTCATGC GGTTTTTCGGGGGGCTGGTGTCGTGGGTCACCCAGGACGAGCTAGCGAGCGTCACCGCCG TGTGCGCCGGGCCCCAGG AGGCGGCGCACACCGGCCACCCGGGCCGGCCCCGCTCGGCCGTGATCCTCCCGGCGTGTG CGTTCGTGGACCTGGACG CCGAGCTGGGGCTGGGGGGCCCGGGCGCGGCGTTTCTGTACCTGGTATTCACTTACCGCC AGCGCCGGGACCAGGAGC TGTGTTGTGTGTACGTGATCAAGAGCCAGCTCCCCCCGCGCGGGTTGGAGCCGGCCCTGG AGCGGCTGTTTGGGCGCC TCCGGATCACCAACACGATTCACGGCACCGAGGACATGACGCCCCCGGCCCCAAACCGAA ACCCCGACTTCCCCCTCG CGGGCCTGGCCGCCAATCCCCAAACCCCGCGTTGCTCGGCTGGCCAGGTCACGAACCCCC AGTTCGCCGACAGGCTGT ACCGCTGGCAGCCGGACCTTCGGGGGCGCCCCACCGCACGCACCTGTACGTACGCCGCCT TTGCAGAGCTCGGCATGA TGCCCGAGGATAGTCCCCGCTGCCTGCACCGCACCGAGCGCTTTGGGGCGGTCAGCGTCC CCGTTGTTATTCTGGAAG GCGTGGTGTGGCGCCCCGGCGAGTGGCGGGCATGCGCGTGAGCGTAGCAAACGCCCCGCC CACACAACGCTCCGCCCC CAACCCCTTCCCCGCTGTCACTCGTGGTTCGTTGACCCGGACGTCCGCCAAATAAAGCCA CTGAAACCCGAAACGCGA GTGTTGTAACGTCCTTTGGGCGGGAGGAAGCCCGTATAGCATACATTATACGAAGTTATA GCGCGAAGTTCCTATTCT CTAGAAAGTATAGGAACTTCGAATTGGTCGACGGATCCAACCGCGGAAGACCCAGGCCGC CTCGGGTGTAACGTTAGA CCGAGTTCGCCGGGCCGGCTCCGCGGGCCAGGGCCCGGGCACGGGCCTCGGGCCCCAGGC ACGGCCCGATGACCGCCT CGGCCTCCGCCACCCGGCGCCGGAACCGAGCCCGGTCGGCCCGCTCGCGGGCCCACGAGC CGCGGCGCGCCAGGCGGG CGGCCGAGGCCCAGACCACCAGGTGGCGCACCCGGACGTGGGGCGAGAAGCGCACCCGCG TGGGGGTCGCGGGGGTCG CGGGGGTCGCGGGGGGCTTCGGCGCCCCCTCCCCGCCCGCGCGTCGCAGGCGCAGGCGCG CCAGGTGCTCTGCGGTGA CGCGCAGGCGGAGGGCGAGGCGCGGCGGAAGGCGGAAGGGGCGTGAGGGGGGGTGGGAGG GGTTAGCCCCGCCCCCCG

GGCCCGCGCCGGGCGGTGGGGGCCGGGGCCGGGGGGCGGCGGCGGTGGGCCGGGCCT CTGGCGCCGGCTCGGGCGGGG

GGCTGTCCGGCCAGTCGTCGTCATCGTCGTCGTCGGACGCGGACTCGGGAACGTGGA GCCACTGGCGCAGCAGCAGCG

AACAAGAAGGCGGGGGCCCACTGGCGGGGGGCGGCGGCGGGGCGGCCGCGGGCGCGC TCCTGACCACGGGTTCCGAGT

TGGGCGTGGAGGTTACCTGGGACTGTGCGGTTGGGACGGCGCCCGTGGGCCCGGGCG GCCGGGGGCGGCGGGGGCCGC

GATGGCGGCGGCGGCGGGCCATGATCAAGCTCATGGCGCCGCGCTCTGCTTCTGGAA GGCTGCGCTCCGCGGCGTGGA

TGCTCCGGGGAAAGTTGCGCTCCGCGGCAGGGATGCTCCTGGGAAGGTTGCGCTCCG CGGCAGGGATGCTCTGGGGAA

GGCTGGTCCTGGCCGAGGATCGGGAACGCGCCGCTCGCTCTGCTTCTCTTGTCTTCG CTTGTCTCTGGATGGAACCAG

ATTTGGTTCTGAGTAGCTGTCAGCGTCTGGTGACCTGCTCGCCGCCCTGCGCCTTTA AGGAGTCTTCACCGGCCCCGC

CCACTCTCCGCTGGGCCAATCAGCGAGCCGGAGGAGGCCTTGGGGCCAGGAATCTTC CAGCAGTTTCGCGTCTGGTGG

AGCTTCCCCGCCTCCCTTGAGTAATCGGAGTTGTGGGTTCCGCCCTTGTCCAGAACT CTCCAGAGGTTTCTGGGGTTC

ACTGGAGAGTACGGATTCCTGAGGGGGAGGGTGTGGGGAAGTGCTGGTGCTACTAGT GACACTGTTGCTATGGCGACG

CATTACTAAGGCCTGTGTGGAATGGACAAGAAAGATCACCTCTAGCTCGGTGTTGTG TACAGTTTGTTGTGATTTGTG

GGGTTTCGCCAACTCGCACAGTTCTGAATATGGGGGTTAAAGGCTAAAACTTAAGGG CTAAAACTTCTCCCCGCCAAG

TTTAGGAGACCCAGGGAGATGCCTGGGGGCGTGTCCGGTGACGTGATCCTCTCCAAT CGCGTTACAATGGCAGTGCTG

CCTCTGACCTCATGGACTAATTTAGGAACTAGAGGCTCTGTCCCAGCACAGGCTCAA AGTTGCCGGGAGGGGCGGGGT

GGGGGGTGGGGGGGACCCCGGCTGCTCAGTTTGGATGTTCCTGGAGCTCGGTACCCG CGATCGCCCCTAGAGGATCTA

CTAGTCATATGGATAAGCCTGGGAACCTCGTCCAGGTGTCTGCAACCGAGAGTTCTC AGCCTCCAGCAGAGTCCTGGT

GGGGAGTGGGGAGATAGGGTCAGCTCCAGCTGAGGTAGCATGTCCTGCCACTGCAGG ATCAATCTCTATTGTGACCAT

T GT C AT AT AAAAG C C AC AC AGT CAT AT AC C C AC AGAT AT AT AC T T AG C C AAC C CAT AT T T GAGACAC AGG GAGAC C C C

ACAT G CAGAT T C C C ACAGT C G GAG G CAG G G C CAAAT GAAT T G C T AAC AC T TAT AT C AGAC T C C T CAGAT C AGT CT C C G

CCTCCCCACCCAAGGCCAAGGCCGATGACCTCATCCTCTGGGAGGGAGGCCGATTCT CATGCTAATTATTGCCTTTTG

TCCACACTACCATCTGGAGGGCCTAAGAAGGGAGGGCTCCTCAGGGGAAGTGGGAAT TCTCAGGCTGTTCCCAGGGGA

TGGCTCTCTCTCTGCCCCCAGAGCTGGTAACAGACAAAAGCAAATGAATTCAGCTCC CCTTCTCCAAATCCTTTTCAG

ACCTCAAACGCCAGTGGTTACATTCCTCAGAGCTGCCTGGACCCTTCCCCTCAGAGG ACTGACTGGGGCTAAAGCCCT

CATCTCAGGATCACAAACTCTTCAGGGATCGGATCTCGGCCCGGGCTAGCACGCGTA AGAGCTCGGTACCTATCGATA

GAGAAATGTTCTGGCACCTGCACTTGCACTGGGGACAGCCTATTTTGCTAGTTTGTT TTGTTTCGTTTTGTTTTGATG

GAGAG C GT AT GT T AGT AC TAT C GAT T C AC AC AAAAAAC C AAC AC AC AGAT GT AAT GAAAAT AAAGAT AT T T TAT T G C G

GCGATCCGGAACCCTTAAT (SEQ ID NO: 1)

[00146] SEQ ID NO: 2 Nestin Promoter

aaccctgaag agtttgtgat cctgagatga gggctttagc cccagtcagt cctctgaggg 60

gaagggtcca ggcagctctg aggaatgtaa ccactggcgt ttgaggtctg aaaaggattt 120

ggagaagggg agctgaattc atttgctttt gtctgttacc agctctgggg gcagagagag 180

agccatcccc tgggaacagc ctgagaattc ccacttcccc tgaggagccc tcccttctta 240

ggccctccag atggtagtgt ggacaaaagg caataattag catgagaatc ggcctccctc 300

ccagaggatg aggtcatcgg ccttggcctt gggtggggag gcggagactg atctgaggag 360

tctgatataa gtgttagcaa ttcatttggc cctgcctccg actgtgggaa tctgcatgtg 420 gggtctccct gtgtctcaaa tatgggttgg ctaagtatat atctgtgggt atatgactgt 480

gtggctttta tatgacaatg gtcacaatag agattgatcc tgcagtggca ggacatgcta 540

cctcagctgg agctgaccct atctccccac tccccaccag gactctgctg gaggctgaga 600

actctcggtt gcagacacct ggacgaggtt caggcttatc atatgactag tagatcctct 660

aggggcgatc gcgggtaccg agctccagga acatccaaac tgagcagccg gggtcccccc 720

caccccccac cccgcccctc ccggcaactt tgagcctgtg ctgggacaga gcctctagtt 780

cctaaattag tccatgaggt cagaggcagc actgccattg taacgcgatt ggagaggatc 840

acgtcaccgg acacgccccc aggcatctcc ctgggtctcc taaacttggc ggggagaagt 900

tttagccctt aagttttagc ctttaacccc catattcaga actgtgcgag ttggcgaaac 960

cccacaaatc acaacaaact gtacacaaca ccgagctaga ggtgatcttt cttgtccatt 1020

ccacacaggc cttagtaatg cgtcgccata gcaacagtgt cactagtagc accagcactt 1080

ccccacaccc tccccctcag gaatccgtac tctccagtga accccagaaa cctctggaga 1140

gttctggaca agggcggaac ccacaactcc gattactcaa gggaggcggg gaagctccac 1200

cagacgcgaa actgctggaa gattcctggc cccaaggcct cctccggctc gctgattggc 1260

ccagcggaga gtgggcgggg ccggtgaaga ctccttaaag gcgcagggcg gcgagcaggt 1320

caccagacgc tgacagctac tcagaaccaa atctggttcc atccagagac aagcgaagac 1380

aagagaagca gagcgagcgg cgcgttcccg atcctcggcc aggaccagcc ttccccagag 1440

catccctgcc gcggagcgca accttcccag gagcatccct gccgcggagc gcaactttcc 1500

ccggagcatc cacgccgcgg agcgcagcct tccagaagca 1540 (SEQ ID NO: 2)

[00147] UL39 Sequences ribonucleotide reductase subunit 1 [Human herpesvirus 1]

LOCUS NP_044641 1137 aa linear VRL 24-AUG-2010

DEFINITION ribonucleotide reductase subunit 1 [Human herpesvirus 1].

ACCESSION NP 044641

VERSION NP 044641.1 GL9629420

DBLINK BioProject: PRJNA15217

DBSOURCE REFSEQ: accession NC 001806.1

KEYWORDS RefSeq.

SOURCE Human herpesvirus 1 (Herpes simplex virus 1)

ORGANISM Human herpesvirus 1

Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;

Alphaherpesvirinae; Simplexvirus.

REFERENCE 1 (residues 1 to 1137)

AUTHORS McGeoch,D.J., Dalrymple,M.A., Davison, A. J., Dolan,A-, Frame,M.C,

McNab,D., Perry ,L.J., Scott,J.E. and Taylor,P.

TITLE The complete DNA sequence of the long unique region in the genome

of herpes simplex virus type 1

JOURNAL J. Gen. Virol. 69 (PT 7), 1531-1574 (1988)

PUBMED 2839594

REFERENCE 2 (residues 1 to 1137)

CONSRTM NCBI Genome Project

TITLE Direct Submission JOURNAL Submitted (01 -AUG-2000) National Center for Biotechnology

Information, NIH, Bethesda, MD 20894, USA

REFERENCE 3 (residues 1 to 1137)

AUTHORS McGeoch,D.J.

TITLE Direct Submission

JOURNAL Submitted (17-JAN-1989) McGeoch D.J., MRC Virology Institute, Institute of Virology, Church Street, Glasgow Gi l 5JR, GB

COMMENT PROVISIONAL REFSEO: This record has not yet been subject to final NCBI review. The reference sequence was derived from CAA32314.

CURATION: The original gene nomenclature has been retained. Genes presumably inherited from the common ancestor of alpha-, beta- and gammaherpesviruses (core genes) and non-core genes presumably

inherited from the ancestor of alphaherpesviruses (alpha genes) are indicated. Initiation codons are assigned with as much confidence

as is possible for each protein-coding region. A standard protein

nomenclature has been applied so that orthologs have the same name in all herpesviruses. Protein information may have been propagated from other herpesvirus species.

Method: conceptual translation.

FEATURES Location/Qualifiers

source 1..1137

/organism="Human herpesvirus 1"

/strain="17"

/host="Homo sapiens"

/db xref="taxon: 10298"

/acronym="HHV-l"

/acronym="HSV-l"

Protein 1..1137

/product- 'ribonucleotide reductase subunit 1"

/EC number=" 1.17.4.1"

/function- 'nucleotide metabolism"

/note= "translation initiation factor-associated protein

(N -terminal region)"

/calculated_mol_wt= 123920

Region 491..576

/region_name= "Ribonuc red lgN"

/note= "Ribonucleotide reductase, all-alpha domain;

pfam00317"

/db xref="CDD:249765"

Region 537..1113

/region_name="RNR_PFL"

/note="Ribonucleotide reductase and Pyruvate formate

lyase; cl09939"

/db xref="CDD:245211"

Region 580..1113

/region_name="Ribonuc_red_lgC"

/note="Ribonucleotide reductase, barrel domain; pfam02867" /db xref="CDD:251578"

CDS 1. 1137 /gene="UL39"

/locus_tag="HHVlgp057"

/coded_by="NC_001806.1:86444..89857"

/db xref="GOA:P08543"

/db_xref="InterPro :IPR000788"

/db_xref="InterPro :IPR003010"

/db xref="UniProtKB/Swiss-Prot:P08543 "

/db xref="GeneID:2703361"

ORIGIN

1 masφaass vearapvggq eaggpsaatq geaagaplah ghhvycqrvn gvmvlsdktp

61 gsasyrisdn nfvqcgsnct miidgdwrg φqdpgaaas papfvavtni gagsdggtav

121 vafggtprrs agtstgtqta dvptealggp pppprftlgg gccscrdtrr rsavfggegd

181 pvgpaefvsd drssdsdsdd sedtdsetls hassdvsgga tyddaldsds ssddslqidg

241 pvcrpwsndt apldvcpgtp gpgadaggps avdphaptpe agaglaadpa varddaegls

301 dprprlgtgt aypvpleltp enaeavarfl gdavnrepal mleyfcrcar eetkrvpprt

361 fgspprlted dfgllnyalv emqrlcldvp pvppnaympy ylreyvtrlv ngfkplvsrs

421 arlyrilgvl vhlrirtrea sfeewlrske valdfglter lreheaqlvi laqaldhydc

481 lihstphtlv erglqsalky eefylkrfgg hymesvfqmy triagflacr atrgmrhial

541 gregswwemf kfffhrlydh qivpstpaml nlgtrnyyts scylvnpqat tnkatlrait

601 snvsailarn ggiglcvqaf ndsgpgtasv mpalkvldsl vaahnkesar ptgacvylep

661 whtdvravlr mkgvlageea qrcdnifsal wmpdlffkrl irhldgeknv twtlfdrdts

721 msladfhgee feklyqhlev mgfgeqipiq elaygivrsa attgspfvmf kdavnrhyiy

781 dtqgaaiags nlcteivhpa skrssgvcnl gsvnlarcvs rqtfdfgrlr davqacvlmv

841 nimidstlqp tpqctrgndn lrsmgigmqg lhtaclklgl dlesaefqdl nkhiaevmll

901 samktsnalc vrgarpfnhf krsmyragrf hwerfpdarp ryegewemlr qsmmkhglrn

961 sqfvalmpta asaqisdvse gfaplftnlf skvtrdgetl φηΐΐΐϋίεΐ ertfsgkrll

1021 evmdsldakq wsvaqalpcl epthplrrfk tafdydqkll idlcadrapy vdhsqsmtly

1081 vtekadgtlp astlvrllvh aykrglktgm yyckvrkatn sgvfggddni vcmscal (SEQ ID NO: 3)

[00148] Nestin 2 ^nd intron sequence SEQ ID NO: 4

aaccctgaag agtttgtgat cctgagatga gggctttagc cccagtcagt cctctgaggg 60

gaagggtcca ggcagctctg aggaatgtaa ccactggcgt ttgaggtctg aaaaggattt 120

ggagaagggg agctgaattc atttgctttt gtctgttacc agctctgggg gcagagagag 180

agccatcccc tgggaacagc ctgagaattc ccacttcccc tgaggagccc tcccttctta 240

ggccctccag atggtagtgt ggacaaaagg caataattag catgagaatc ggcctccctc 300

ccagaggatg aggtcatcgg ccttggcctt gggtggggag gcggagactg atctgaggag 360

tctgatataa gtgttagcaa ttcatttggc cctgcctccg actgtgggaa tctgcatgtg 420

gggtctccct gtgtctcaaa tatgggttgg ctaagtatat atctgtgggt atatgactgt 480

gtggctttta tatgacaatg gtcacaatag agattgatcc tgcagtggca ggacatgcta 540

cctcagctgg agctgaccct atctccccac tccccaccag gactctgctg gaggctgaga 600

actctcggtt gcagacacct ggacgaggtt 630 (SEQ ID NO: 4) [00149] hsp68: heat shock protein 68 SEQ ID NO: 5

caggcttatc atatgactag tagatcctct aggggcgatc gcgggtaccg agctccagga 60

acatccaaac tgagcagccg gggtcccccc caccccccac cccgcccctc ccggcaactt 120

tgagcctgtg ctgggacaga gcctctagtt cctaaattag tccatgaggt cagaggcagc 180

actgccattg taacgcgatt ggagaggatc acgtcaccgg acacgccccc aggcatctcc 240

ctgggtctcc taaacttggc ggggagaagt tttagccctt aagttttagc ctttaacccc 300

catattcaga actgtgcgag ttggcgaaac cccacaaatc acaacaaact gtacacaaca 360

ccgagctaga ggtgatcttt cttgtccatt ccacacaggc cttagtaatg cgtcgccata 420

gcaacagtgt cactagtagc accagcactt ccccacaccc tccccctcag gaatccgtac 480

tctccagtga accccagaaa cctctggaga gttctggaca agggcggaac ccacaactcc 540

gattactcaa gggaggcggg gaagctccac cagacgcgaa actgctggaa gattcctggc 600

cccaaggcct cctccggctc gctgattggc ccagcggaga gtgggcgggg ccggtgaaga 660

ctccttaaag gcgcagggcg gcgagcaggt caccagacgc tgacagctac tcagaaccaa 720

atctggttcc atccagagac aagcgaagac aagagaagca gagcgagcgg cgcgttcccg 780

atcctcggcc aggaccagcc ttccccagag catccctgcc gcggagcgca accttcccag 840

gagcatccct gccgcggagc gcaactttcc ccggagcatc cacgccgcgg agcgcagcct 900

tccagaagca 910 (SEQ ID NO: 5)

[00150] Genome sequence of UL39 is (nts. 86217..90988) of NC_001806.1 (SEQ ID NO: 6)

86217 acaa caggtgggtg ctttggaaac ttgccggtcg ccgtgctcct gtgagcttgc gtccctcccc

86281 ggtttccttt gcgctcccgc cttccggacc tgctctcgcc tatcttcttt ggctctcggt

86341 gcgattcgtc aggcagcggc cttgtcgaat ctcgacccca ccactcgccg gacccgccga

86401 cgtcccctct cgagcccgcc gaaacccgcc gcgtctgttg aaatggccag ccgcccagcc

86461 gcatcctctc ccgtcgaagc gcgggccccg gttgggggac aggaggccgg cggccccagc

86521 gcagccaccc agggggaggc cgccggggcc cctctcgccc acggccacca cgtgtactgc

86581 cagcgagtca atggcgtgat ggtgctttcc gacaagacgc ccgggtccgc gtcctaccgc

86641 atcagcgata gcaactttgt ccaatgtggt tccaactgca ccatgatcat cgacggagac

86701 gtggtgcgcg ggcgccccca ggacccgggg gccgcggcat cccccgctcc cttcgttgcg 86761 gtgacaaaca tcggagccgg cagcgacggc gggaccgccg tcgtggcatt cgggggaacc 86821 ccacgtcgct cggcggggac gtctaccggt acccagacgg ccgacgtccc caccgaggcc 86881 cttgggggcc cccctcctcc tccccgcttc accctgggtg gcggctgttg ttcctgtcgc 86941 gacacacggc gccgctctgc ggtattcggg ggggaggggg atccagtcgg ccccgcggag 87001 ttcgtctcgg acgaccggtc gtccgattcc gactcggatg actcggagga cacggactcg 87061 gagacgctgt cacacgcctc ctcggacgtg tccggcgggg ccacgtacga cgacgccctt 87121 gactccgatt cgtcatcgga tgactccctg cagatagatg gccccgtgtg tcgcccgtgg 87181 agcaatgaca ccgcgcccct ggatgtttgc cccgggaccc ccggcccggg cgccgacgcc 87241 ggtggtccct cagcggtaga cccacacgcg ccgacgccag aggccggcgc tggtcttgcg 87301 gccgatcccg ccgtggcccg ggacgacgcg gaggggcttt cggacccccg gccacgtctg 87361 ggaacgggca cggcctaccc cgtccccctg gaactcacgc ccgagaacgc ggaggccgtg 87421 gcgcgctttc tgggagatgc cgtgaaccgc gaacccgcgc tcatgctgga gtacttttgc 87481 cggtgcgccc gcgaggaaac caagcgtgtc ccccccagga cattcggcag cccccctcgc 87541 ctcacggagg acgactttgg gcttctcaac tacgcgctcg tggagatgca gcgcctgtgt 87601 ctggacgttc ctccggtccc gccgaacgca tacatgccct attatctcag ggagtatgtg 87661 acgcggctgg tcaacgggtt caagccgctg gtgagccggt ccgctcgcct ttaccgcatc 87721 ctgggggttc tggtgcacct gcggatccgg acccgggagg cctcctttga ggagtggctg 87781 cgatccaagg aagtggccct ggattttggc ctgacggaaa ggcttcgcga gcacgaagcc 87841 cagctggtga tcctggccca ggctctggac cattacgact gtctgatcca cagcacaccg 87901 cacacgctgg tcgagcgggg gctgcaatcg gccctgaagt atgaggagtt ttacctaaag 87961 cgttttggcg ggcactacat ggagtccgtc ttccagatgt acacccgcat cgccggcttt 88021 ttggcctgcc gggccacgcg cggcatgcgc cacatcgccc tggggcgaga ggggtcgtgg 88081 tgggaaatgt tcaagttctt tttccaccgc ctctacgacc accagatcgt accgtcgacc 88141 cccgccatgc tgaacctggg gacccgcaac tactacacct ccagctgcta cctggtaaac 88201 ccccaggcca ccacaaacaa ggcgaccctg cgggccatca ccagcaacgt cagtgccatc 88261 ctcgcccgca acgggggcat cgggctatgc gtgcaggcgt ttaacgactc cggccccggg 88321 accgccagcg tcatgcccgc cctcaaggtc cttgactcgc tggtggcggc gcacaacaaa 88381 gagagcgcgc gtccgaccgg cgcgtgcgtg tacctggagc cgtggcacac cgacgtgcgg 88441 gccgtgctcc ggatgaaggg ggtcctcgcc ggcgaagagg cccagcgctg cgacaatatc 88501 ttcagcgccc tctggatgcc agacctgttt ttcaagcgcc tgattcgcca cctggacggc 88561 gagaagaacg tcacatggac cctgttcgac cgggacacca gcatgtcgct cgccgacttt 88621 cacggggagg agttcgagaa gctctaccag cacctcgagg tcatggggtt cggcgagcag 88681 atacccatcc aggagctggc ctatggcatt gtgcgcagtg cggccacgac cgggagcccc 88741 ttcgtcatgt tcaaagacgc ggtgaaccgc cactacatct acgacaccca gggggcggcc 88801 atcgccggct ccaacctctg caccgagatc gtccatccgg cctccaagcg atccagtggg 88861 gtctgcaacc tgggaagcgt gaatctggcc cgatgcgtct ccaggcagac gtttgacttt 88921 gggcggctcc gcgacgccgt gcaggcgtgc gtgctgatgg tgaacatcat gatcgacagc 88981 acgctacaac ccacgcccca gtgcacccgc ggcaacgaca acctgcggtc catgggaatc 89041 ggcatgcagg gcctgcacac ggcctgcctg aagctggggc tggatctgga gtctgccgaa 89101 tttcaggacc tgaacaaaca catcgccgag gtgatgctgc tgtcggcgat gaagaccagc 89161 aacgcgctgt gcgttcgcgg ggcccgtccc ttcaaccact ttaagcgcag catgtatcgc 89221 gccggccgct ttcactggga gcgctttccg gacgcccggc cgcggtacga gggcgagtgg 89281 gagatgctac gccagagcat gatgaaacac ggcctgcgca acagccagtt tgtcgcgctg 89341 atgcccaccg ccgcctcggc gcagatctcg gacgtcagcg agggctttgc ccccctgttc 89401 accaacctgt tcagcaaggt gacccgggac ggcgagacgc tgcgccccaa cacgctcctg 89461 ctaaaggaac tggaacgcac gtttagcggg aagcgcctcc tggaggtgat ggacagtctc 89521 gacgccaagc agtggtccgt ggcgcaggcg ctcccgtgcc tggagcccac ccaccccctc 89581 cggcgattca agaccgcgtt tgactacgac cagaagttgc tgatcgacct gtgtgcggac 89641 cgcgccccct acgtcgacca tagccaatcc atgaccctgt atgtcacgga gaaggcggac 89701 gggaccctcc cagcctccac cctggtccgc cttctggtcc acgcatataa gcgcggacta 89761 aaaacaggga tgtactactg caaggttcgc aaggcgacca acagcggggt ctttggcggc 89821 gacgacaaca ttgtctgcat gagctgcgcg ctgtgaccga caaaccccct ccgcgccagg 89881 cccgccgcca ctgtcgtcgc cgtcccacgc tctcccctgc tgccatggat tccgcggccc 89941 cagccctctc ccccgctctg acggccctta cgggccagag cgcgacggcg gacctggcga 90001 tccagattcc aaagtgcccc gaccccgaga ggtacttcta cacctcccag tgtcccgaca 90061 ttaaccacct gcgctccctc agcatcctta accgctggct ggaaaccgag cttgttttcg 90121 tgggggacga ggaggacgtc tccaagcttt ccgagggcga gctcagcttt taccgcttcc 90181 tcttcgcttt cctgtcggcc gccgacgacc tggttacgga aaacctgggc ggcctctccg 90241 gcctgtttga gcagaaggac attctccact actacgtgga gcaggaatgc atcgaagtcg 90301 tacactcgcg cgtgtacaac atcatccagc tggtgctttt ccacaacaac gaccaggcgc 90361 gccgcgagta cgtggccggt accatcaacc acccggccat ccgcgccaag gtggactggt 90421 tggaagcgcg ggtgcgggaa tgcgcctccg ttccggaaaa gttcattctc atgatcctca 90481 tcgagggcat cttttttgcc gcctcgtttg ccgccatcgc ctaccttcgc accaacaacc 90541 ttctgcgggt cacctgccag tcaaacgacc tcatcagccg ggacgaggcc gtgcacacga 90601 cggcctcgtg ttacatctac aacaactacc tcggcgggca cgccaagccc ccgcccgacc 90661 gcgtgtacgg gctgttccgc caggcggtcg agatcgagat cggatttatc cgatcccagg 90721 cgccgacgga cagccatatc ctgagcccgg cggcgctggc ggccatcgaa aactacgtgc 90781 gattcagcgc ggatcgcctg ttgggcctta tccacatgaa gccactgttt tccgccccac 90841 cccccgacgc cagctttccg ctgagcctca tgtccaccga caaacacacc aattttttcg 90901 agtgtcgcag cacctcctac gccggggcgg tcgtcaacga tctgtgagtg tcgcggcgcg 90988 cttctacccg tgtttgccca taataaac

>del-seq of fHSV Quik-1 (SEQ ID NO: 7)

aataaagccactgaaacccgaaacgcgagtgttgtaacgtcctttgggcgggaggaagcc acaaaatgca aatgggatacatggaaggaacacacccccgtgactcaggacatcggtgtgtccttttggg tttcactgaa actggcccgcgccccacccctgcgcgatgtggataaaaagccagcgcgggtggtttaggg taccacaggt gggtgctttggaaacttgccggtcgccgtgctcctgtgagcttgcgtccctccccggttt cctttgcgct cccgccttccggacctgctctcgcctactcttctttggctctcggtgcgattcgtcaggc agcggccttg tcgaatctcgaccccaccactcgccggacccgccgacgtcccctcagcttgcatgcctgc aggtcgagcc cgccgaaacccgccgcgtctgttgaaatggccagccgccccgccgcatcctctcccgtcg aagcgcgggc cccggttgggggacaggaggccggcggccccagcgcagccacccagggggaggccgccgg ggcccctctc gcccgcggccaccacgtgtactgccagcgagtcaatggcgtgatggtgctttccgacaag acgcccgggt ccgcgtcctaccgcatcagcgatagcaactttgtccaatgtggttccaactgcaccatga tcatagacgg agacgtggtgcgcgggcgcccccaggacccgggggccgcggcatcccccgctcccttcgt tgcggtgaca aacatcggagccggcagcgacggcgggaccgccgtcgtggcattcgggggaaccccacgt cgctcggcgg ggacgtctaccggtacccagacgaccgacgtccccaccgaggcccttgggggcccccctc ctcctccccg cttcaccctgggtggcggctgttgttcctgtcgcgacacacggcgccgctctgcggtatt cgggggggag ggggatcgatccatcgccaccatggtgagcaagggcgaggagctgttcaccggggtggtg cccatcctgg tcgagctggacggcgacgtaaacggccacaagttcagcgtgtccggcgagggcgagggcg atgccaccta cggcaagctgaccctgaagttcatctgcaccaccggcaagctgcccgtgccctggcccac cctcgtgacc accctgacctacggcgtgcagtgcttcagccgctaccccgaccacatgaagcagcacgac ttcttcaagt ccgccatgcccgaaggctacgtccaggagcgcaccatcttcttcaaggacgacggcaact acaagacccg cgccgaggtgaagttcgagggcgacaccctggtgaaccgcatcgagctgaagggcatcga cttcaaggag gacggcaacatcctggggcacaagctggagtacaactacaacagccacaacgtctatatc atggccgaca agcagaagaacggcatcaaggtgaacttcaagatccgccacaacatcgaggacggcagcg tgcagctcgc cgaccactaccagcagaacacccccatcggcgacggccccgtgctgctgcccgacaacca ctacctgagc acccagtccgccctgagcaaagaccccaacgagaagcgcgatcacatggtcctgctggag ttcgtgaccg ccgccgggatcactctcggcatggacgagctgtacaagtaaagcggccgatcc (SEQ ID NO: 7) >PCR-del-GFP-FRT-Gm-F&R (SEQ ID NO: 08)

aataaagccactgaaacccgaaacgcgagtgttgtaacgtcctttgggcgggaggaa gcccgtatagcat acattatacgaagttatagcgcgaagttcctattctctagaaagtataggaacttcaagc tttaaacttt tgccattctcaccggattcagtcgtcactcatggtgatttctcacttgataaccttattt ttgacgaggg gaaattaggccgggaagccgatctcggcttgaacgaattgttaggtggcggtacttgggt cgatatcaaa gtgcatcacttcttcccgtatgcccaactttgtatagagagccactgcgggatcgtcacc gtaatctgct tgcacgtagatcacataagcaccaagcgcgttggcctcatgcttgaggagattgatgagc gcggtggcaa tgccctgcctccggtgctcgccggagactgcgagatcatagatatagatctcactacgcg gctgctcaaa cttgggcagaacgtaagccgcgagagcgccaacaaccgcttcttggtcgaaggcagcaag cgcgatgaat gtcttactacggagcaagttcccgaggtaatcggagtccggctgatgttgggagtaggtg gctacgtctc cgaactcacgaccgaaaagatcaagagcagcccgcatggatttgacttggtcagggccga gcctacatgt gcgaatgatgcccatacttgagccacctaactttgttttagggcgactgccctgctgcgt aacatcgttg ctgctgcgtaacatcgttgctgctccataacatcaaacatcgacccacggcgtaacgcgc ttgctgcttg gatgcccgaggcatagactgtacaaaaaaacagtcataacaagccatgaaaaccgccact gcgccgttac caccgctgcgttcggtcaaggttctggaccagttgcgtgagcgcatacgctacttgcatt acagtttacg aaccgaacaggcttatgtcaactgggttcgtgccttcatccgtttccacggtgtgcgtca cccggcaacc ttgggcagcagcgaagtcgaggcatttctgtcctggctggcgaacgagcgcaaggtttcg gtctccacgc atcgtcaggcattggcggccttgctgttcttctacggcaaggtgctgtgaccgccgccgg gatcactctc ggcatggacgagctgtacaagtaaagcggccgatcc (SEQ ID N0:8)