Title:
ONCOLYTIC VIRUS EXPRESSING INTERFERON AND APPLICATION THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/135390
Kind Code:
A1
Abstract:
Provided is an oncolytic virus expressing an interferon. Specifically provided is an oncolytic adenovirus expressing an interferon hybrid protein, said oncolytic virus being capable of effectively suppressing tumors in vitro and in vivo.
More Like This:
Inventors:
ZHANG KANGJIAN (CN)
FANG XIANLONG (CN)
GU JINFA (CN)
LIU XINYUAN (CN)
FANG XIANLONG (CN)
GU JINFA (CN)
LIU XINYUAN (CN)
Application Number:
PCT/CN2019/127782
Publication Date:
July 02, 2020
Filing Date:
December 24, 2019
Export Citation:
Assignee:
SHANGHAI YUANSONG BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K35/761; C12N7/01; A61P35/00
Foreign References:
| CN1509764A | 2004-07-07 | |||
| CN105769819A | 2016-07-20 | |||
| EP2537527A2 | 2012-12-26 | |||
| US4695623A | 1987-09-22 | |||
| US4897471A | 1990-01-30 | |||
| CN201810651914A | 2018-06-22 |
Other References:
PENG, LINHUI : "The payload of mouse interferon-gamma gene enhances the antitumor activity of the oncolytic adenovirus CNHK300 in hepatocellular carcinoma", CHINESE JOURNAL OF EXPERIMENTAL SURGERY, vol. 28, no. 6, 30 June 2011 (2011-06-30), pages 920 - 922, XP009528795, ISSN: 1001-9030
PENG LINHUI , ZHOU JIE , HUO FENG , ZHANG SHILIN ,ZHANG QI , SU CHANGQING , QIAN QIJUN , SHI YANG : "Killing effect and mIFN-gamma expression of the replicative oncolytic adenovirus CNHK300-mIFN-gamma on gastrointestinal malignant tumor in vitro", CHONGQING MEDICINE, vol. 41, no. 22, 31 August 2012 (2012-08-31), pages 2233 - 2236, XP055825548, ISSN: 1671-8348, DOI: 10.3969/j.issn.1671-8348.2012.22.001
PENG LIN-HUI, ZHOU JIE, HUO FENG, PU MIAO-SHUI, ZHANG QI, SU CHANG-QING, QIAN QI-JUN, WAN YUN-LE: "Killing effect and mIFN-gamma expression of gene-viral therapeutic system CNHK300-mIFN-gamma on malignant tumor cells in vitro", CHINESE JOURNAL OF PATHOPHYSIOLOGY, vol. 28, no. 5, 31 December 2012 (2012-12-31), CN, pages 802 - 806, XP009528809, ISSN: 1000-4718
KIRN ET AL., NAT. MED., vol. 7, 2001, pages 781
COFFEY ET AL., SCIENCE, vol. 282, 1998, pages 1332
LORENCE ET AL., CANCER RES., vol. 54, 1994, pages 6017
PENG ET AL., BLOOD, vol. 98, 2001, pages 2002
See also references of EP 3907281A4
PENG LINHUI , ZHOU JIE , HUO FENG , ZHANG SHILIN ,ZHANG QI , SU CHANGQING , QIAN QIJUN , SHI YANG : "Killing effect and mIFN-gamma expression of the replicative oncolytic adenovirus CNHK300-mIFN-gamma on gastrointestinal malignant tumor in vitro", CHONGQING MEDICINE, vol. 41, no. 22, 31 August 2012 (2012-08-31), pages 2233 - 2236, XP055825548, ISSN: 1671-8348, DOI: 10.3969/j.issn.1671-8348.2012.22.001
PENG LIN-HUI, ZHOU JIE, HUO FENG, PU MIAO-SHUI, ZHANG QI, SU CHANG-QING, QIAN QI-JUN, WAN YUN-LE: "Killing effect and mIFN-gamma expression of gene-viral therapeutic system CNHK300-mIFN-gamma on malignant tumor cells in vitro", CHINESE JOURNAL OF PATHOPHYSIOLOGY, vol. 28, no. 5, 31 December 2012 (2012-12-31), CN, pages 802 - 806, XP009528809, ISSN: 1000-4718
KIRN ET AL., NAT. MED., vol. 7, 2001, pages 781
COFFEY ET AL., SCIENCE, vol. 282, 1998, pages 1332
LORENCE ET AL., CANCER RES., vol. 54, 1994, pages 6017
PENG ET AL., BLOOD, vol. 98, 2001, pages 2002
See also references of EP 3907281A4
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
Download PDF: