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Title:
ONE-POT METHOD FOR PREPARING TWIN DICARBOXYLIC ACID DIAMINE COMPLEX PLATINUM (II) DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2019/161526
Kind Code:
A1
Abstract:
Provided is a one-pot method for preparing twin dicarboxylic acid diamine complex platinum (II) derivatives, the method does not comprise the separation of intermediate carboplatin or carboplatin analogue. Compared with the prior art, according to the method, after the carboplatin or the carboplatin analogue are formed by reaction, no processing is needed to obtain purified carboplatin or carboplatin analogue product, and the carboplatin or carboplatin analogue can directly reacts with dicarboxylic acid to obtain twin dicarboxylic acid diamine complex platinum (II) derivatives. The whole process only requires a process of distillation and dehydration once, the overall energy consumption is low, and the production cycle is short, with a single batch production cycle can be controlled within 2 days. Water alone is used as a solvent, which is environmentally friendly and produces less amount of liquid waste. The obtained product has high purity and does not require further purification, and the product quality is stable.

Inventors:
YANG, Xuqing (3FWest Zone of Grand Rock Plaza, No.13 Xinzhong Xili Dongcheng District, Beijing 7, 100027, CN)
PU, Shaoping (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
CONG, Yanwei (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
LIU, Qixing (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
WANG, Yingfei (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
PENG, Juan (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
Application Number:
CN2018/076951
Publication Date:
August 29, 2019
Filing Date:
February 22, 2018
Export Citation:
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Assignee:
KUNMING GUIYAN PHARMACEUTICAL CO., LTD. (Kunming Institute of Precious Metals, No. 988 Keji Road High-tech Development Zon, Kunming Yunnan 6, 650106, CN)
International Classes:
C07C229/76; C07C51/09; C07C61/06; C07F11/00; C07F15/00
Foreign References:
CN1311183A2001-09-05
CN1125731A1996-07-03
CN1460683A2003-12-10
CN86101365A1987-09-23
CN1821253A2006-08-23
CN101723982A2010-06-09
CN1948323A2007-04-18
CN101092433A2007-12-26
CN101289468A2008-10-22
CN85107559A1986-06-10
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (7th Floor, Scitech PlaceNo.22, Jian Guo Men Wai Ave., Chao Yang District, Beijing 4, 100004, CN)
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