Title:
OPHTHALMIC COMPOSITION
Document Type and Number:
WIPO Patent Application WO1999038497
Kind Code:
A3
Abstract:
The ophthalmic composition of this invention is used for treatment of diabetic corneal lesion and/or for treatment of deteriorated corneal esthesia, which comprises, as an active ingredient, a compound represented by general formula (I): wherein A and B are independently lower alkylene, X, Y, and Z are independently halogen, or a pharmacologically acceptable salt thereof. In addition, the ophthalmic composition of this invention is used for treatment of non-diabetic corneal lesion, for treatment of dry eye syndrome, and/or for treatment of hypolacrimation which comprises, as an active ingredient, an aldose reductase inhibitor. The ophthalmic compositions of this invention are effective for treatment of at least one disease selected among corneal lesion, deteriorated corneal esthesia, dry eye syndrome, and hypolacrimation.
Inventors:
UENO RYUJI (US)
KATO ICHIE (JP)
KATO ICHIE (JP)
Application Number:
PCT/JP1999/000369
Publication Date:
March 09, 2000
Filing Date:
January 29, 1999
Export Citation:
Assignee:
R TECH UENO LTD (JP)
UENO RYUJI (US)
KATO ICHIE (JP)
UENO RYUJI (US)
KATO ICHIE (JP)
International Classes:
A61K31/00; A61K31/505; A61K31/517; A61P27/02; (IPC1-7): A61K31/505; A61K31/00
Foreign References:
| EP0218999A2 | 1987-04-22 | |||
| US5582835A | 1996-12-10 | |||
| EP0170237A2 | 1986-02-05 | |||
| EP0719767A1 | 1996-07-03 | |||
| EP0124327A2 | 1984-11-07 |
Other References:
PATENT ABSTRACTS OF JAPAN vol. 013, no. 372 (C - 627) 17 August 1989 (1989-08-17)
SHIZUO AO ET AL.: "EFFECT OF A NOVEL ALDOSE REDUCTASE INHIBITOR "FR74366" ON DIABETIC CATARACT", INT. CONGR. SER. - EXCERPTA MEDICA, 1990, pages 221 - 224, XP002110639
MAMORU MATSUDA ET AL.: "The effects of aldose reductase inhibitor on the corneal endothelial morphology in diabetic rats", CURRENT EYE RESEARCH, vol. 6, no. 2, 1987, pages 391 - 397, XP002110640
AO S ET AL: "CHARACTERIZATION OF A NOVEL ALDOSE REDUCTASE INHIBITOR, FR74366, AND ITS EFFECTS ON DIABETIC CATARACT AND NEUROPATHY IN THE RAT", METABOLISM, CLINICAL AND EXPERIMENTAL, vol. 40, no. 1, 1 January 1991 (1991-01-01), pages 77 - 87, XP000654446, ISSN: 0026-0495
TSUBOTA K.: "New approaches to dry-eye therapy.", INTERNATIONAL OPHTHALMOLOGY CLINICS, (1994) 34/1 (115-128)., XP002120709
FUJISHIMA H ET AL: "Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study.", CORNEA, (1996 JUL) 15 (4) 368-75., XP002120710
AWATA T ET AL: "Effect of an aldose reductase inhibitor, CT-112, on healing of the corneal epithelium in galactose-fed rats.", JOURNAL OF OCULAR PHARMACOLOGY, (1988 FALL) 4 (3) 195-201., XP002120711
TSUBOTA K ET AL: "The effect of aldose reductase inhibitor on the corneal epithelium.", CORNEA, (1993 MAR) 12 (2) 161-2., XP000852574
SHIZUO AO ET AL.: "EFFECT OF A NOVEL ALDOSE REDUCTASE INHIBITOR "FR74366" ON DIABETIC CATARACT", INT. CONGR. SER. - EXCERPTA MEDICA, 1990, pages 221 - 224, XP002110639
MAMORU MATSUDA ET AL.: "The effects of aldose reductase inhibitor on the corneal endothelial morphology in diabetic rats", CURRENT EYE RESEARCH, vol. 6, no. 2, 1987, pages 391 - 397, XP002110640
AO S ET AL: "CHARACTERIZATION OF A NOVEL ALDOSE REDUCTASE INHIBITOR, FR74366, AND ITS EFFECTS ON DIABETIC CATARACT AND NEUROPATHY IN THE RAT", METABOLISM, CLINICAL AND EXPERIMENTAL, vol. 40, no. 1, 1 January 1991 (1991-01-01), pages 77 - 87, XP000654446, ISSN: 0026-0495
TSUBOTA K.: "New approaches to dry-eye therapy.", INTERNATIONAL OPHTHALMOLOGY CLINICS, (1994) 34/1 (115-128)., XP002120709
FUJISHIMA H ET AL: "Improvement of corneal sensation and tear dynamics in diabetic patients by oral aldose reductase inhibitor, ONO-2235: a preliminary study.", CORNEA, (1996 JUL) 15 (4) 368-75., XP002120710
AWATA T ET AL: "Effect of an aldose reductase inhibitor, CT-112, on healing of the corneal epithelium in galactose-fed rats.", JOURNAL OF OCULAR PHARMACOLOGY, (1988 FALL) 4 (3) 195-201., XP002120711
TSUBOTA K ET AL: "The effect of aldose reductase inhibitor on the corneal epithelium.", CORNEA, (1993 MAR) 12 (2) 161-2., XP000852574
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